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A Dramatic Change in the Correlation of Forces
Paul Craig Roberts
https://www.paulcraigroberts.org/2024/12/12/a-dramatic-change-in-the-correlation-of-forces/

PCR interviewed on Coffee and a Mike
Events in Syria Have Changed the Correlation of Forces
https://www.paulcraigroberts.org/2024/12/12/events-in-syria-have-changed-the-correlation-of-forces/

The “Syrian Democratic Opposition” at Work
https://www.paulcraigroberts.org/2024/12/12/he-syrian-democratic-opposition-at-work/

Provocations of Russia Continue
https://www.paulcraigroberts.org/2024/12/12/provocations-of-russia-continue/

FBI Director Resigns
https://www.paulcraigroberts.org/2024/12/12/fbi-director-resigns/

2 hrs ago


Two new species of amphipods associated with the bioinvasive coral Tubastraea coccinea from Todos-os-Santos Bay are described. The bioinvasive sun coral is known for competing with native coral species, which shelter a big diversity of associated fauna, especially amphipods. Leucothoe oxumae sp. nov. shows acute rostrum, antenna 1 about 1/4 of body length; gnathopod 1 carpochelate, propodus with 5 anterodistal robust setae; gnathopod 2 propodus fusiform, slightly serrated on palmar margin and posterodistal corner of epimeral plate 3 produced and rounded. Stenothoe ogumi sp. nov. is unique by showing a pronounced and developed maxilliped inner plate, gnathopod 2 propodus palm pointed with slightly undulated processes and two developed ones near hinge of dactylus and palmar margin beset with dense fringe of long setae. Updated taxonomic key to Leucothoe and Stenothoe species from Brazil are provided.A new species of the genus Dendrelaphis is described from Xishuangbanna, southern Yunnan, China, based on molecular and morphological data. The new species can be differentiated from other congeners by the following combination of characters 1) ground color of body bronze, a black postocular stripe extending onto the neck only; 2) pale and dark ventrolateral stripe absent; 3) relatively indistinct transverse bands on the anterior part of lateral body; 4) loreal single; 5) vertebral scales strongly enlarged; 6) dorsal scale rows 15-15-11, all smooth; 7) ventrals 193-197, subcaudals 130-135, paired; 8) SVL/TOL ratio 0.292-0.301; 9) supralabials 9, 4th through 6th touching the eye; 10) the outermost row of dorsal scales the same color as other dorsal scales; 11) retracted hemipenis extending to the 6-7th subcaudal scales. According to molecular and morphological data, D. ngansonensis likely belongs to the D. cyanochloris complex. We further discussed D. cyanochloris complex from Tibet, Yunnan and Hainan, China. A key to Chinese species of Dendrelaphis is provided.Catomus aeolicus sp. https://www.selleckchem.com/products/Odanacatib-(MK0822).html nov. is described from the Aeolian archipelago (Sicily, Italy). The new species differs from the other European Catomus by having distinctly bent tibiae, longer antennae (especially in males), and strongly highlighted sexual dimorphism. The shape of the aedeagus also seems diagnostic for this new species.The genus Termitodiellus Nakane, 1961 is a member of the tribe Rhyparini, which includes several morphologically similar genera. Members of Rhyparini can be readily recognized by their carinate dorsal surface, elytral apex with bulbous projection bearing trichomes, hastate posterior prosternal process, and greatly reduced tibial spurs (Howden Storey 1992, 2000; Skelley 2007; Howden 1995; Pittino 2006).The description of the male of the species Quwatanabius chiaw (Smetana, 1995) is provided for the first time, including a habitus photo and illustrations of the aedeagus. A brief discussion of the endemic status of Q. chiaw on the island of Taiwan, as well as additional Taiwanese material of the wide-spread Q. flavicornis (Sharp, 1889) are also provided.The genus Ukamenia Oku (1981) was proposed with Simaethis sapporensis Matsumura (1931) from Japan as its type species, which had been originally described in the family Choreutidae. Oku (1981) based the new genus on characters of S. sapporensis that were typical of Tortricidae rather than Choreutidae, notably the naked haustellum (scaled in Choreutidae), among many other characters differing between the two families, such as wing venation, head morphology, and genital form. Oku (1981) assigned his new genus to the tribe Olethreu-tini, but mentioned that it resembled the genus Gatesclarkeana Diakonoff, 1966. In her extensive study of Australian Olethreutinae, Horak (2006) briefly noted Ukamenia as being referable to Gateclark-eanini.A new geometrid species, Archedontia agnesae sp. n. is described from Tadjikistan. The new genus Archedontia gen. n. is assigned to the sterrhine tribe Rhodometrini, aside genus Ochodontia Lederer. Adult moth, male and female genitalia are figured and described, and COI barcode data analysed.The type material of three Empis s. str. species described by J.E. Collin from Egypt and Syria are revised E. demissa, E. insulata and E. nigropilosa. Lectotypes for Empis insulata Collin, 1937 (Syria) and E. demissa Collin, 1949 (Egypt) are designated. A key to species of Empis s. str. of Egypt, Israel and Syria is provided.Here we consider the morphotypes and changing species composition of naked amoebae in soils of forest areas in Zhytomyr region (Ukraine). The species composition and morphotypes of amoebae are influenced by the microclimate of soil and litter. Complexes of naked amoebae in the study area constitute two clusters one of broadleaf (oak) and mixed forests, another of coniferous forests. The most similar species compositions were found in soils of oak and mixed forests (64 % similarity). The least similar were amoebae complexes of coniferous forests and oak forests, and coniferous forests and mixed forests. Non-parametric multidimensional scaling (MDS) showed that species complex of amoebae of mixed forests and oak forests had moister and more acidic soils compared to coniferous forests.A new species of the hitherto monotypic spider genus Proislandiana Tanasevitch, 1985 is described from the high altitude belt of Ararat Mountain (Turkey) and Aragats Mountain (Armenia). The genus Proislandiana is reviewed, its taxonomic relationships to the other genera are discussed. The diagnoses of the genus and its type species are revised. The distribution and the zoogeography of the two known Proislandiana species are summarized and discussed.This paper brings a series of contributions to the taxonomy of the Zethini description of a new species, Zethus denticlypeus Lopes, sp. n.; description of the female of Z. anomalus Cooper, 1999; description of the males of Z. angustior Bohart Stange, 1965, Z. clypeolaris Bohart Stange, 1965, Z. satanicus Bohart Stange, 1965 and Argentozethus willinki Stange, 1979; synonymy of Discoelius argentinus Brèthes, 1905 under Z. dicomboda Spinola, 1851; and rearrangements for the species of Raphiglossoides Giordani Soika, 1936, with Raphiglossoides minutus (Gusenleitner, 2000) (= R. aethiopicus Giordani Soika, 1936) and R. gibbus (Gusenletiner, 2000) n. comb.

2 hrs ago


ctions, especially in children.UTI has been reported as the most prevalent infectious complication after-kidney transplantation. This study aimed to evaluate the bacterial urinary tract infection among renal transplant recipients, and causative microorganisms from the Middle East. We searched literatures reporting the prevalence of UTI, bacterial pathogens, and antibiotic resistance pattern from January 1, 2010-May 10, 2020 for patients with renal transplant recipients from the Middle East in international databases. Terms used were; "Urinary tract infection", "UTI", "bacterial pathogens", "bacterial infection", "renal transplant", "kidney transplant", post - renal transplant, "antibiotic resistance", "Middle East", Turkey, Iran, Jordan, Kuwait, Bahrain, Lebanon, United Arab Emirates, Qatar, Cyprus, Yemen, Iraq, Egypt, Palestine, and Syria. Data analyzed using CMA software. The prevalence of UTI among renal transplant recipients from the Middle East varied between 4.5 and 85%. The combined prevalence of UTI was reported by 37.9% (95% Cl 28.3-48.5). The most prevalent organisms recovered from urine samples of patients with UTI were E. coli and Klebsiella with prevalence rate of 57.5%, and 15%, respectively. Also, Coagulase negative Staphylococcus (15%), and Enterococci (11.2%) were the most predominant among Gram positive microorganisms. The most resistance among Gram negative microorganisms belonged to Ceftazidime with frequency of 90% followed by Carbenicillin and Cephalexin with prevalence of 87.3%, and 84%, respectively. The effective antibiotic was Imipenem (15.2%). Regarding the high UTI rate in renal transplant recipients from the Middle East, and the significant presence of both Gram negative and Gram positive microorganisms as the most prevalent uropathogens after renal transplantation should be considered when selecting empirical antibacterial therapy.Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus that it disease spreads in over the world. Coronaviruses are single-stranded, positive-sense RNA viruses with a genome of approximately 30 KD, the largest genome among RNA viruses. Most people infected with the COVID-19 virus will experience mild to moderate respiratory illness and recover without requiring special treatment. Older people and those with underlying medical problems like cardiovascular disease, diabetes, chronic respiratory disease, and cancer are more likely to develop serious illness. At this time, there are no specific vaccines or treatments for COVID-19. So, there is an emergency need for vaccines and antiviral strategies. The spike protein is the major surface protein that it uses to bind to a receptor of another protein that acts as a doorway into a human cell. The putative antigenic epitopes may prove effective as novel vaccines for eradication and combating of COV19 infection. A combination of available bioinformatics tools are used to synthesis of such peptides that are important for the development of a vaccine. In conclusion, amino acids 250-800 were selected as effective B cell epitopes, T cell epitopes, and functional exposed amino acids in order to a recombinant vaccine against coronavirus.Plant fungal diseases generate serious losses in the agriculture. The bacteria producing biologically active substances that inhibit the growth of fungal pathogens can be an alternative to the chemicals. The chitinolytic bacteria were isolated from the rhizosphere of wheat (Triticum aestivum L.) and their physiological properties which may be useful in the promotion of plant growth have been investigated. Their chitinases and antifungal activity were studied. The isolates were also tested for indirect growth-promoting traits such as ammonia production, siderophore production, hydrogen cyanide production, and salicylic acid production. Two chitinolytic strains B3 and B5 were identified as Bacillus subtilis and Bacillus sp., respectively. They produced active chitinases on a medium containing shrimp shell powder. The purified chitinases having the molecular weight of 35-45 kDa inhibited the growth of important plant pathogens such as Alternaria alternata, and Fusarium oxysporum. Additionally, the isolates showed the ability to produce a broad range of biological substances promoting the growth of plants.Candida haemulonii species complex (Can. haemulonii sensu stricto, Can. duobushaemulonii and Can. haemulonii var. vulnera) and related species (Can. auris and Can. pseudohaemulonii) have attracted attention due to reduced susceptibility to azoles and amphotericin B. Furthermore, attributes of potential virulence have been recognized in Can. https://www.selleckchem.com/ALK.html haemulonii species complex and Can. auris, like the capability to form biofilm, which represent the most important risk factors for persistent candidemia. However, the relationship between biofilm production and impact on host mortality is still unclear. To evaluate the potential virulence of Can. haemulonii species complex and Can. auris isolates by correlating biofilm production and capacity to kill Caenorhabditis elegans as an in vivo model. In this study, virulence factors were characterized among a total of sixty-six Can. haemulonii species complex and Can. auris isolates to gain insight about virulence traits of these pathogenic yeasts by evaluating the in vitro biofilm production and potential pathogenicity for Cae. elegans, as an in vivo infection model. All clinical isolates tested were biofilm producer, inter- and intra-specific differences on the biofilm forming capacity by the strains were observed. Can. auris and Can. haemuolonii var. vulnera showed similar biofilm production, both higher than Can. haemulonii sensu stricto and Can. duobushaemulonii. Regarding the virulence of the Cae. elegans model, Can. haemulonii species complex and Can. auris isolates were capable of causing infection in Cae. elegans, and our data suggest that the high biofilm production by Can. haemulonii var. vulnera and Can. duobushaemulonii isolates may impact in the pathogenicity caused on Cae. elegans.Mutations affecting SQSTM1 coding for p62 and TANK-Binding Kinase 1 (TBK1) have been implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). TBK1 is a serine-threonine kinase that regulates p62's activity as an autophagy receptor via phosphorylation and also has roles in neuroinflammatory signalling pathways. The mechanisms underlying ALS and FTLD pathogenesis as a result of TBK1 mutations are incompletely understood, however, loss of TBK1 function can lead to dysregulated autophagy and mitophagy. Here, we report that an ALS-associated TBK1 variant affecting the kinase domain, p.G175S, is defective in phosphorylation of p62 at Ser-403, a modification critical for regulating its ubiquitin-binding function, as well as downstream phosphorylation at Ser-349. Consistent with these findings, expression of p.G175S TBK1 was associated with decreased induction of autophagy compared to wild type and reduced degradation of the ALS-linked protein TDP-43. Expression of wild type TBK1 increased NF-κB signalling ~300 fold in comparison to empty vector cells, whereas p.

Videos

12/02/2024

Today on “Truth in Media”, the situation in Syria continues to deteriorate. It looks like an all-out war is in the making.

Militants have fanned out from the northern city of Aleppo and renewed their offensive. Meanwhile, the U.S. is conducting airstrikes against the Syrian government and allied forces.

Russia is also taking the battle to the air in support of its ally Syria, as tens of thousands of Iraqi Shia soldiers have entered the country to aid President Assad’s embattled forces.

So, are we heading to World War III officially? When will these proxy wars spill out into a full-fledged war pitting the West against Russia, Iran, and its allies?

Joining me today is independent investigative journalist, Vanessa Beeley, here to discuss the growing world-war dynamic in the Middle East and the ongoing genocide in Gaza that is now being recreated in Lebanon with little to no push back by the supposed "rules-based international order". We also discuss how the global technocratic elitists are using Gaza as a testbed for artificial intelligence -- fine tuning for future military use on a mass scale, as well as domestic control structures -- and how the rising global resistance is not just about the future of Gaza, but the future of us all. 

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06/19/2024

In today’s episode of “Direct Impact,” Rick Sanchez explores the underlying motivations behind America’s involvement in Ukraine, citing statements from Hungarian leader Victor Orban and US Senator Lindsey Graham that suggest financial interests are at play. Rick also highlights Tucker Carlson’s interview with Congressman Thomas Massie, who discusses the powerful influence of the Israel Lobby, AIPAC, over US politicians. Finally, Rick has a discussion with Kevork Almassian, host of Syriana Analysis, to uncover the reasons behind Syria’s ongoing crisis.

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Videos

12/02/2024

Today on “Truth in Media”, the situation in Syria continues to deteriorate. It looks like an all-out war is in the making.

Militants have fanned out from the northern city of Aleppo and renewed their offensive. Meanwhile, the U.S. is conducting airstrikes against the Syrian government and allied forces.

Russia is also taking the battle to the air in support of its ally Syria, as tens of thousands of Iraqi Shia soldiers have entered the country to aid President Assad’s embattled forces.

So, are we heading to World War III officially? When will these proxy wars spill out into a full-fledged war pitting the West against Russia, Iran, and its allies?

Joining me today is independent investigative journalist, Vanessa Beeley, here to discuss the growing world-war dynamic in the Middle East and the ongoing genocide in Gaza that is now being recreated in Lebanon with little to no push back by the supposed "rules-based international order". We also discuss how the global technocratic elitists are using Gaza as a testbed for artificial intelligence -- fine tuning for future military use on a mass scale, as well as domestic control structures -- and how the rising global resistance is not just about the future of Gaza, but the future of us all. 

All Video Source Links Can Be Found Here At The Last American Vagabond: https://www.thelastamericanvagabond.com/vanessa-beeley-interview-10-18-24

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06/19/2024

In today’s episode of “Direct Impact,” Rick Sanchez explores the underlying motivations behind America’s involvement in Ukraine, citing statements from Hungarian leader Victor Orban and US Senator Lindsey Graham that suggest financial interests are at play. Rick also highlights Tucker Carlson’s interview with Congressman Thomas Massie, who discusses the powerful influence of the Israel Lobby, AIPAC, over US politicians. Finally, Rick has a discussion with Kevork Almassian, host of Syriana Analysis, to uncover the reasons behind Syria’s ongoing crisis.

04/27/2024

On this episode of The MO, host Manila Chan delves into an ntriguing discussion with Timothy J. Gordon about Pope Francis. They explore the Pope's leadership style and the Church's stance on land ownership, offering insights into the complexities of these issues within the Catholic community.

Welcome to The Daily Wrap Up, a concise show dedicated to bringing you the most relevant independent news, as we see it, from the last 24 hours.

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Today's postings, December 12, 2024, www.paulcraigroberts.org

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A Dramatic Change in the Correlation of Forces
Paul Craig Roberts
https://www.paulcraigroberts.org/2024/12/12/a-dramatic-change-in-the-correlation-of-forces/

PCR interviewed on Coffee and a Mike
Events in Syria Have Changed the Correlation of Forces
https://www.paulcraigroberts.org/2024/12/12/events-in-syria-have-changed-the-correlation-of-forces/

The “Syrian Democratic Opposition” at Work
https://www.paulcraigroberts.org/2024/12/12/he-syrian-democratic-opposition-at-work/

Provocations of Russia Continue
https://www.paulcraigroberts.org/2024/12/12/provocations-of-russia-continue/

FBI Director Resigns
https://www.paulcraigroberts.org/2024/12/12/fbi-director-resigns/

2 hrs ago


Two new species of amphipods associated with the bioinvasive coral Tubastraea coccinea from Todos-os-Santos Bay are described. The bioinvasive sun coral is known for competing with native coral species, which shelter a big diversity of associated fauna, especially amphipods. Leucothoe oxumae sp. nov. shows acute rostrum, antenna 1 about 1/4 of body length; gnathopod 1 carpochelate, propodus with 5 anterodistal robust setae; gnathopod 2 propodus fusiform, slightly serrated on palmar margin and posterodistal corner of epimeral plate 3 produced and rounded. Stenothoe ogumi sp. nov. is unique by showing a pronounced and developed maxilliped inner plate, gnathopod 2 propodus palm pointed with slightly undulated processes and two developed ones near hinge of dactylus and palmar margin beset with dense fringe of long setae. Updated taxonomic key to Leucothoe and Stenothoe species from Brazil are provided.A new species of the genus Dendrelaphis is described from Xishuangbanna, southern Yunnan, China, based on molecular and morphological data. The new species can be differentiated from other congeners by the following combination of characters 1) ground color of body bronze, a black postocular stripe extending onto the neck only; 2) pale and dark ventrolateral stripe absent; 3) relatively indistinct transverse bands on the anterior part of lateral body; 4) loreal single; 5) vertebral scales strongly enlarged; 6) dorsal scale rows 15-15-11, all smooth; 7) ventrals 193-197, subcaudals 130-135, paired; 8) SVL/TOL ratio 0.292-0.301; 9) supralabials 9, 4th through 6th touching the eye; 10) the outermost row of dorsal scales the same color as other dorsal scales; 11) retracted hemipenis extending to the 6-7th subcaudal scales. According to molecular and morphological data, D. ngansonensis likely belongs to the D. cyanochloris complex. We further discussed D. cyanochloris complex from Tibet, Yunnan and Hainan, China. A key to Chinese species of Dendrelaphis is provided.Catomus aeolicus sp. https://www.selleckchem.com/products/Odanacatib-(MK0822).html nov. is described from the Aeolian archipelago (Sicily, Italy). The new species differs from the other European Catomus by having distinctly bent tibiae, longer antennae (especially in males), and strongly highlighted sexual dimorphism. The shape of the aedeagus also seems diagnostic for this new species.The genus Termitodiellus Nakane, 1961 is a member of the tribe Rhyparini, which includes several morphologically similar genera. Members of Rhyparini can be readily recognized by their carinate dorsal surface, elytral apex with bulbous projection bearing trichomes, hastate posterior prosternal process, and greatly reduced tibial spurs (Howden Storey 1992, 2000; Skelley 2007; Howden 1995; Pittino 2006).The description of the male of the species Quwatanabius chiaw (Smetana, 1995) is provided for the first time, including a habitus photo and illustrations of the aedeagus. A brief discussion of the endemic status of Q. chiaw on the island of Taiwan, as well as additional Taiwanese material of the wide-spread Q. flavicornis (Sharp, 1889) are also provided.The genus Ukamenia Oku (1981) was proposed with Simaethis sapporensis Matsumura (1931) from Japan as its type species, which had been originally described in the family Choreutidae. Oku (1981) based the new genus on characters of S. sapporensis that were typical of Tortricidae rather than Choreutidae, notably the naked haustellum (scaled in Choreutidae), among many other characters differing between the two families, such as wing venation, head morphology, and genital form. Oku (1981) assigned his new genus to the tribe Olethreu-tini, but mentioned that it resembled the genus Gatesclarkeana Diakonoff, 1966. In her extensive study of Australian Olethreutinae, Horak (2006) briefly noted Ukamenia as being referable to Gateclark-eanini.A new geometrid species, Archedontia agnesae sp. n. is described from Tadjikistan. The new genus Archedontia gen. n. is assigned to the sterrhine tribe Rhodometrini, aside genus Ochodontia Lederer. Adult moth, male and female genitalia are figured and described, and COI barcode data analysed.The type material of three Empis s. str. species described by J.E. Collin from Egypt and Syria are revised E. demissa, E. insulata and E. nigropilosa. Lectotypes for Empis insulata Collin, 1937 (Syria) and E. demissa Collin, 1949 (Egypt) are designated. A key to species of Empis s. str. of Egypt, Israel and Syria is provided.Here we consider the morphotypes and changing species composition of naked amoebae in soils of forest areas in Zhytomyr region (Ukraine). The species composition and morphotypes of amoebae are influenced by the microclimate of soil and litter. Complexes of naked amoebae in the study area constitute two clusters one of broadleaf (oak) and mixed forests, another of coniferous forests. The most similar species compositions were found in soils of oak and mixed forests (64 % similarity). The least similar were amoebae complexes of coniferous forests and oak forests, and coniferous forests and mixed forests. Non-parametric multidimensional scaling (MDS) showed that species complex of amoebae of mixed forests and oak forests had moister and more acidic soils compared to coniferous forests.A new species of the hitherto monotypic spider genus Proislandiana Tanasevitch, 1985 is described from the high altitude belt of Ararat Mountain (Turkey) and Aragats Mountain (Armenia). The genus Proislandiana is reviewed, its taxonomic relationships to the other genera are discussed. The diagnoses of the genus and its type species are revised. The distribution and the zoogeography of the two known Proislandiana species are summarized and discussed.This paper brings a series of contributions to the taxonomy of the Zethini description of a new species, Zethus denticlypeus Lopes, sp. n.; description of the female of Z. anomalus Cooper, 1999; description of the males of Z. angustior Bohart Stange, 1965, Z. clypeolaris Bohart Stange, 1965, Z. satanicus Bohart Stange, 1965 and Argentozethus willinki Stange, 1979; synonymy of Discoelius argentinus Brèthes, 1905 under Z. dicomboda Spinola, 1851; and rearrangements for the species of Raphiglossoides Giordani Soika, 1936, with Raphiglossoides minutus (Gusenleitner, 2000) (= R. aethiopicus Giordani Soika, 1936) and R. gibbus (Gusenletiner, 2000) n. comb.

2 hrs ago


ctions, especially in children.UTI has been reported as the most prevalent infectious complication after-kidney transplantation. This study aimed to evaluate the bacterial urinary tract infection among renal transplant recipients, and causative microorganisms from the Middle East. We searched literatures reporting the prevalence of UTI, bacterial pathogens, and antibiotic resistance pattern from January 1, 2010-May 10, 2020 for patients with renal transplant recipients from the Middle East in international databases. Terms used were; "Urinary tract infection", "UTI", "bacterial pathogens", "bacterial infection", "renal transplant", "kidney transplant", post - renal transplant, "antibiotic resistance", "Middle East", Turkey, Iran, Jordan, Kuwait, Bahrain, Lebanon, United Arab Emirates, Qatar, Cyprus, Yemen, Iraq, Egypt, Palestine, and Syria. Data analyzed using CMA software. The prevalence of UTI among renal transplant recipients from the Middle East varied between 4.5 and 85%. The combined prevalence of UTI was reported by 37.9% (95% Cl 28.3-48.5). The most prevalent organisms recovered from urine samples of patients with UTI were E. coli and Klebsiella with prevalence rate of 57.5%, and 15%, respectively. Also, Coagulase negative Staphylococcus (15%), and Enterococci (11.2%) were the most predominant among Gram positive microorganisms. The most resistance among Gram negative microorganisms belonged to Ceftazidime with frequency of 90% followed by Carbenicillin and Cephalexin with prevalence of 87.3%, and 84%, respectively. The effective antibiotic was Imipenem (15.2%). Regarding the high UTI rate in renal transplant recipients from the Middle East, and the significant presence of both Gram negative and Gram positive microorganisms as the most prevalent uropathogens after renal transplantation should be considered when selecting empirical antibacterial therapy.Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus that it disease spreads in over the world. Coronaviruses are single-stranded, positive-sense RNA viruses with a genome of approximately 30 KD, the largest genome among RNA viruses. Most people infected with the COVID-19 virus will experience mild to moderate respiratory illness and recover without requiring special treatment. Older people and those with underlying medical problems like cardiovascular disease, diabetes, chronic respiratory disease, and cancer are more likely to develop serious illness. At this time, there are no specific vaccines or treatments for COVID-19. So, there is an emergency need for vaccines and antiviral strategies. The spike protein is the major surface protein that it uses to bind to a receptor of another protein that acts as a doorway into a human cell. The putative antigenic epitopes may prove effective as novel vaccines for eradication and combating of COV19 infection. A combination of available bioinformatics tools are used to synthesis of such peptides that are important for the development of a vaccine. In conclusion, amino acids 250-800 were selected as effective B cell epitopes, T cell epitopes, and functional exposed amino acids in order to a recombinant vaccine against coronavirus.Plant fungal diseases generate serious losses in the agriculture. The bacteria producing biologically active substances that inhibit the growth of fungal pathogens can be an alternative to the chemicals. The chitinolytic bacteria were isolated from the rhizosphere of wheat (Triticum aestivum L.) and their physiological properties which may be useful in the promotion of plant growth have been investigated. Their chitinases and antifungal activity were studied. The isolates were also tested for indirect growth-promoting traits such as ammonia production, siderophore production, hydrogen cyanide production, and salicylic acid production. Two chitinolytic strains B3 and B5 were identified as Bacillus subtilis and Bacillus sp., respectively. They produced active chitinases on a medium containing shrimp shell powder. The purified chitinases having the molecular weight of 35-45 kDa inhibited the growth of important plant pathogens such as Alternaria alternata, and Fusarium oxysporum. Additionally, the isolates showed the ability to produce a broad range of biological substances promoting the growth of plants.Candida haemulonii species complex (Can. haemulonii sensu stricto, Can. duobushaemulonii and Can. haemulonii var. vulnera) and related species (Can. auris and Can. pseudohaemulonii) have attracted attention due to reduced susceptibility to azoles and amphotericin B. Furthermore, attributes of potential virulence have been recognized in Can. https://www.selleckchem.com/ALK.html haemulonii species complex and Can. auris, like the capability to form biofilm, which represent the most important risk factors for persistent candidemia. However, the relationship between biofilm production and impact on host mortality is still unclear. To evaluate the potential virulence of Can. haemulonii species complex and Can. auris isolates by correlating biofilm production and capacity to kill Caenorhabditis elegans as an in vivo model. In this study, virulence factors were characterized among a total of sixty-six Can. haemulonii species complex and Can. auris isolates to gain insight about virulence traits of these pathogenic yeasts by evaluating the in vitro biofilm production and potential pathogenicity for Cae. elegans, as an in vivo infection model. All clinical isolates tested were biofilm producer, inter- and intra-specific differences on the biofilm forming capacity by the strains were observed. Can. auris and Can. haemuolonii var. vulnera showed similar biofilm production, both higher than Can. haemulonii sensu stricto and Can. duobushaemulonii. Regarding the virulence of the Cae. elegans model, Can. haemulonii species complex and Can. auris isolates were capable of causing infection in Cae. elegans, and our data suggest that the high biofilm production by Can. haemulonii var. vulnera and Can. duobushaemulonii isolates may impact in the pathogenicity caused on Cae. elegans.Mutations affecting SQSTM1 coding for p62 and TANK-Binding Kinase 1 (TBK1) have been implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). TBK1 is a serine-threonine kinase that regulates p62's activity as an autophagy receptor via phosphorylation and also has roles in neuroinflammatory signalling pathways. The mechanisms underlying ALS and FTLD pathogenesis as a result of TBK1 mutations are incompletely understood, however, loss of TBK1 function can lead to dysregulated autophagy and mitophagy. Here, we report that an ALS-associated TBK1 variant affecting the kinase domain, p.G175S, is defective in phosphorylation of p62 at Ser-403, a modification critical for regulating its ubiquitin-binding function, as well as downstream phosphorylation at Ser-349. Consistent with these findings, expression of p.G175S TBK1 was associated with decreased induction of autophagy compared to wild type and reduced degradation of the ALS-linked protein TDP-43. Expression of wild type TBK1 increased NF-κB signalling ~300 fold in comparison to empty vector cells, whereas p.

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Background and Aim Depression has become a serious health and social issue in recent years in China. This study aims to explore the relationship between social capital and depressive symptoms among the elderly in China, with a particular focus on the mediating role of life satisfaction. Methods The data of this study were sourced from the 2016 wave of China Family Panel Studies (CFPS), involving 1243 older adults aged 60 and above. A multiple linear regression model was used to explore the impact of social capital on depressive symptoms. Moreover, the add-on PROCESS macro for SPSS was employed to measure the mediating effect of life satisfaction on the relationship between social capital and depressive symptoms. Results The regression results suggest that CES-D score was associated with trust (coefficient = -0.1013, p less then 0.01). In addition, the protective role of trust was significantly stronger for older adults aged 70-79, women, the poorest 1/3, and the elderly who live in rural areas. Moreover, the mediation analysis results suggest that the effect of trust on depressive symptoms was fully mediated by life satisfaction. Conclusion This study reveals that social capital has a positive effect on depressive symptoms among the elderly, and the positive health effect shows significant age, gender, income, and location inequalities. https://www.selleckchem.com/products/L-Adrenaline-Epinephrine.html Furthermore, this study also provides new evidence indicating that life satisfaction fully mediates the relationship between social capital and depressive symptoms. Improving social capital could be a promising way for China to promote healthy aging in the future. © 2020 Sun et al.Background Despite healthcare facilities being deemed untouchable in times of conflict, the war in Syria has seen its government as well as opposition forces, target their people and infrastructure as a strategy of war. Violations of medical neutrality and International Humanitarian Law has led to the loss of countless medical personnel, civilians and health care facilities; setting the country back to health levels last seen thirty years ago. It is evident through the strategy of the Syrian and Russian government that healthcare facilities are being deliberately targeted with humanitarian organisations condemning all parties involved for violating the Geneva Conventions. The report examines the impact of the conflict in Syria on its health facilities and looks at the reasons why these services are under attack and the international response to the conflict. The report concludes by looking into plans currently implemented to protect our healthcare infrastructure during times of war whilst comparing it to pastacilities from humanitarian violations as health care continues to be targeted as a strategy of war. The number of attacks has steadily remained constant throughout the years and nothing seems to be done in bringing perpetrators to justice for violations of International Humanitarian Law. The paper calls for more public attention to shed light on the atrocities being committed and further inquiries like the preliminary carried out by The Lancet - American University of Beirut. © 2020 Omar.Alcohol withdrawal syndrome (AWS) is a common, heterogenous, and life-threatening complication of alcohol use disorder (AUD). AUD is a leading cause of worldwide mortality, and many patients with AUD will develop AWS during their ED course. This review summarizes the epidemiology, pathology, and management of AWS and AUD in the emergency setting. The time course of AWS and its impact on ED treatment is emphasized. Once AWS is diagnosed, symptom-triggered benzodiazepine administration remains the most commonly provided treatment but may not be appropriate for patients with significant medical or psychiatric comorbidity or pending discharge. In these cases, ED clinicians may consider short courses of barbiturates or alternative regimens based on novel anticonvulsants. Specific treatment protocols are enumerated for clinical practice. Finally, emergency providers must not only manage acute patients' AWS but also lay the foundation for successful treatment of AUD. An approach to the disposition of the patient with AUD is presented. The authors examine shortcomings in the extant literature and suggest opportunities for further study. © 2020 Wolf et al.Introduction Miniscrew-assisted rapid palatal expansion (MARPE) appliances utilize the skeletal anchorage to expand the maxilla. One type of MARPE device is the Maxillary Skeletal Expander (MSE), which presents four micro-implants with bicortical engagement of the palatal vault and nasal floor. MSE positioning is traditionally planned using dental stone models and 2D headfilms. This approach presents some critical issues, such as the inability to identify the MSE position relative to skeletal structures, and the potential risk of damaging anatomical structures. Methods A novel methodology has been developed to plan MSE position using the digital model of dental arches and cone-beam computed tomography (CBCT). A virtual model of MSE appliance with the four micro-implants was created. After virtual planning, a positioning guide is virtually designed, 3D printed, and utilized to model and weld the MSE supporting arms to the molar bands. The expansion device is then cemented in the patient oral cavity and micro-i20 Cantarella et al.Background The annual global neonatal mortality stands at 2.5 million deaths, 1 million of them dying within the first day of life. An additional 2.6 million are stillborn globally, the majority of them due to intrapartum events. Optimal fetal heart rate (FHR) monitoring has the potential to timely detect fetuses at risk and, if coupled with timely obstetric responses may save more newborns. Moyo is a new Doppler with nine crystals capable of monitoring FHR both intermittently and continuously. Aim To assess women's and midwives' opinions on the use of Moyo for intrapartum FHR monitoring. Methods We conducted a cross-sectional study using a structured questionnaire to assess women's and midwives' perception. Women who gave birth at the hospital who used Moyo were interviewed using a questionnaire immediately before discharge from the hospital. Twenty-eight midwives who have been using Moyo for more than 6 months were also interviewed using a structured questionnaire. Data were analyzed using excel and result presented in figures.

9 hrs ago

The Fall of Syria -- One step closer to WWIII?

https://www.naturalnews.com/2024-12-11-fall-of-syria-dangerous-prelude-to-war-with-iran.html

– Geopolitical Implications: The fall of Syria marks a significant shift in the Middle East, with Turkey-backed rebels overthrowing the Assad regime, creating a power vacuum that threatens regional stability, particularly for Iran, Hezbollah, and Russia. – Israel’s Strategic Motives: Israel’s involvement in Syria is seen as part of a broader strategy to weaken Iran, […]

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