1, which lacks the two C-terminal amino acid residues. Our study provides further insight into the role of both Tpm3 products and the C-terminus of Tpm3.1, and it forms the basis for future studies that aim to identify the molecular mechanisms underlying Tpm3.1 targeting to different subcellular compartments.Aedes albopictus and Aedes aegypti are the main vectors of arboviral diseases such as dengue, Zika and chikungunya viruses. About a third of the world population is currently at risk of contracting Aedes-borne epidemics. In recent years, A. albopictus has drastically increased its distribution in many countries. In the absence of efficient mosquito vector control methods, the sterile insect technique (SIT) is presented as a very promising and environment-friendly control tool. The Agriculture Department of the Valencian Region is promoting an ongoing pilot project to evaluate the efficacy of an integrated vector management program (IVM) based on the use of the SIT as the main method of control. The laboratory studies for evaluating the entomological efficacy of SIT through the phased conditional testing process recommended by World Health Organization and the International Atomic Energy Agency (WHO-IAEA) are addressed. This study describes the routine operating procedures and quality control parameters for the medium-scale rearing of sterile male A. albopictus. More than 15 million sterile males have been produced and released in an area of 80 ha between 2018 and 2020. Of the initial L1 larvae, we recovered 17.2% of male pupae after sex sorting to be sterilized and released on the field, while the rest of the pupae remained available to maintain the rearing colony. The residual percentage of females after sex sorting was on average 0.17%. The obtained values in terms of production and quality control as well as the proposed rearing methodology can be useful for designing a medium-scale mosquito-rearing pipeline.Currently, to realize the reliable operation and proper exploitation of complex machines and structures, information regarding the material condition must be obtained. This information should ideally be acquired in a noninvasive manner. In addition, contemporary rapid technological development is conducive to the research and advancement of new methods, including magnetic methods. This publication describes the methods that can enable the extraction of information from the magnetic field, which is valuable for determining the material effort state and performing technical diagnostics. The issue of using the magnetic field to assess the technical condition of structures is a promising trend in technical diagnostics. Moreover, new ways to process the magnetic field information are being identified to connect the observed surface changes in the magnetic field with the significant diagnostic symptoms. https://www.selleckchem.com/products/ly3039478.html This work provides an extensive introduction to the theoretical basis and diagnostic techniques based on measurements of the magnetic field obtained in close proximity to the structure of interest. The key limitations of the method and associated possibilities are highlighted. The model considerations were taken into account to provide a mathematical description of the extraction process and possible interpretations of the acquired signals. According to the received guidelines, the plan and implementation of two experiments are described along with the obtained results, which demonstrated the possibility of identifying valuable information that can be used to determine the state of the material stress and perform diagnostics of steel structures.In this study, we measured the in situ international roughness index (IRI) for first-degree roads spanning more than 1300 km in East Azerbaijan Province, Iran, using a quarter car (QC). Since road quality mapping with in situ measurements is a costly and time-consuming task, we also developed new equations for constructing a road quality proxy map (RQPM) using discriminant analysis and multispectral information from high-resolution Sentinel-2 images, which we calibrated using the in situ data on the basis of geographic information system (GIS) data. The developed equations using optimum index factor (OIF) and norm R provide a valuable tool for creating proxy maps and mitigating hazards at the network scale, not only for primary roads but also for secondary roads, and for reducing the costs of road quality monitoring. The overall accuracy and kappa coefficient of the norm R equation for road classification in East Azerbaijan province are 65.0% and 0.59, respectively.Clinical, epidemiological, and experimental evidence demonstrate non-cancer, cardiovascular, and endocrine effects of ionizing radiation exposure including growth hormone deficiency, obesity, metabolic syndrome, diabetes, and hyperinsulinemia. Insulin-like growth factor-1 (IGF-1) signaling perturbations are implicated in development of cardiovascular disease and metabolic syndrome. The minipig is an emerging model for studying radiation effects given its high analogy to human anatomy and physiology. Here we use a minipig model to study late health effects of radiation by exposing male Göttingen minipigs to 1.9-2.0 Gy X-rays (lower limb tibias spared). Animals were monitored for 120 days following irradiation and blood counts, body weight, heart rate, clinical chemistry parameters, and circulating biomarkers were assessed longitudinally. Collagen deposition, histolopathology, IGF-1 signaling, and mRNA sequencing were evaluated in tissues. Our findings indicate a single exposure induced histopathological changes, attenuated circulating IGF-1, and disrupted cardiac IGF-1 signaling. Electrolytes, lipid profiles, liver and kidney markers, and heart rate and rhythm were also affected. In the heart, collagen deposition was significantly increased and transforming growth factor beta-1 (TGF-beta-1) was induced following irradiation; collagen deposition and fibrosis were also observed in the kidney of irradiated animals. Our findings show Göttingen minipigs are a suitable large animal model to study long-term effects of radiation exposure and radiation-induced inhibition of IGF-1 signaling may play a role in development of late organ injuries.

r polypeptide may promote the proliferation and osteogenic differentiation of BMSCs. Our study lays an experimental foundation for the further development and application of antler polypeptide in medicine.Cutaneous involvement in canine leishmaniasis, caused by Leishmania infantum, is the most frequent clinical manifestation of the zoonotic infectious disease. A 4-month-old female Shih Tzu-terrier dog with significant weight loss and depression and chronic erosive skin lesions around eyes and the area above the nose was presented to the Semnan University Veterinary Hospital teaching, Semnan, Iran. The main clinicopathological findings included marked leukocytosis, neutrophilia, left shift, monocytosis, mild hypoproteinemia, and hypoalbuminemia. The diagnosis of leishmaniasis was performed based on the presence of a large number of Leishmania amastigotes in skin Fine Needle Aspiration (FNA). The dog was euthanized and sent to the autopsy department for further investigation.
More than a hundred species of mammals, birds, and reptiles are infected by nematodes of the
genus worldwide. Although,
spp. are widely distributed in neighboring countries including Georgia, Azerbaijan, Turkey and Iran, no study was conducted in Armenia since 1980's.

In 2017-2018, five muscle samples belonging to Armenian lynx, otter, wild boar, fox and wolf were tested for
spp. and recovered larvae were identified by multiplex PCR technique.

Twenty-six larvae/gram and one larva/gram were found in lynx and fox samples respectively. They were identified as
.

So far only two species were identified in Armenia,
and
, and this is the first time that
is reported in Armenia.
So far only two species were identified in Armenia, T. spiralis and T. pseudospiralis, and this is the first time that T. britovi is reported in Armenia.
is an obligate intracellular parasite, which can infect all nucleated cells in a variety of vertebrate animals, including human, causing toxoplasmosis. Although a number of studies have reported on the seroprevalence of
infection in dogs in China, however, information about
infection in pet dogs in Anhui, China is not available.

The modified agglutination test (MAT) was used to detect antibodies in sera samples from 468 pet dogs at Anhui Province in China from November 2013 to April 2017.

18.6% animals were
seropositive, indicating a slightly higher prevalence of
infection in pet dogs in Anhui, China in comparison with other provinces in China.

Our present study provided epidemiological data on
seroprevalence in pet dogs in Anhui, China for the effective prevention and control of the parasite prevalence in this area.
Our present study provided epidemiological data on T. gondii seroprevalence in pet dogs in Anhui, China for the effective prevention and control of the parasite prevalence in this area.
Soil-transmitted helminth infections constitute a public health problem in the rural areas of tropical and subtropical regions, including Thailand. We aimed to determine the prevalence of soil-transmitted helminth infections and underlying risk factors among the schoolchildren living in the rural areas of southern Thailand.

A cross-sectional survey was conducted between Sep and Nov 2018 in the district of Thasala, Nakhon Si Thammarat, Thailand. A total of 192 children, aged 6-12 yr were enrolled. Each child provided a single stool sample that was subjected to a suite of microscopic diagnoses for soil-transmitted helminth. A questionnaire was administered to determine risk factors of the infections. Logistic regression models were applied to investigate associations.

The overall prevalence of soil-transmitted helminth infections was 3.13%;
2.08%; hookworm 1.04% and
0.52%. Children who cutting fingernails short can prevent soil-transmitted helminth infections highly up to 90% (crude OR = 0.1; 95% confidence interval = 0 - 0.8;
= 0.020).

The finding of the study shows a sharp decrease in the prevalence of soil-transmitted helminth among schoolchildren in the southern Thailand in the past two decades with prevalence dropping below 5% for soil-transmitted helminth. However, the prevalence of
remained stable over time. These results suggest that the culture method should be used to access strongyloidiasis situation in the older age group who greater contact with soil for agriculturists.
The finding of the study shows a sharp decrease in the prevalence of soil-transmitted helminth among schoolchildren in the southern Thailand in the past two decades with prevalence dropping below 5% for soil-transmitted helminth. However, the prevalence of S. stercoralis remained stable over time. These results suggest that the culture method should be used to access strongyloidiasis situation in the older age group who greater contact with soil for agriculturists.
Toxocariasis is a disease caused by
nematodes and occurs from consuming their eggs. The main hosts of these worms are dogs and cats. The disease in humans becomes a visceral larva migrans (VLM). This descriptive cross-sectional study was conducted to determine the prevalence of toxocariasis in children aged 6-14 years.

This cross-sectional descriptive study was conducted from Jun 1 2016 to Dec 1 2017 in Sanandaj, west of Iran. A total of 182 serum samples were collected from children age 6 to14 yr referred to medical diagnostic laboratories. https://www.selleckchem.com/products/colivelin.html Demographic data (age, sex, and parents' literacy status), clinical signs (cough, headache, fever, abdominal pain), and the history of contact with dogs and cats was collected by a questionnaire. The presence of anti-
IgG antibody was detected by
IgG ELISA (IBL, Germany) kit.

Of 182 subjects, 97 (53.3%) were male and 85 (46.7%) female. The average age was 9.2 years. Antibodies against
were positive in three cases (1.65%) of all the studied subjects.

The results showed a low prevalence of toxocariasis in children studied.
The results showed a low prevalence of toxocariasis in children studied.
This epidemiological study aimed to investigate the prevalence of parasitic infections in BuMusa Island, Iran, in one year from 2015 to 2016.

The current cross-sectional study was conducted in coordination with the health authorities of BuMusa on 732 intestinal samples and 1207 blood samples randomly collected from the island residents. Cutaneous lesions of 1207 people were clinically examined and those suspected of parasitic infections were enrolled. Also, 165 intestinal samples from domestic animals, 35 samples from water tanks, and 330 soil samples were taken to the laboratory to be investigated in terms of parasitic infections.

The obtained results showed 26.4% and 45.5% intestinal parasitic infections in humans and animals, respectively. The most prevalent infections in humans were
(8.6%), followed by
(8.2%), and
(6.8%); and the least prevalent infection was
(<0.2%). Malaria agents and
were not observed in blood samples. Investigation of animal feces showed that the highest parasitic infection was
(16.

001), sustained attention (P=0.001), and simple reaction time (P=0.001) were significantly disturbed. The combined effects of noise and low air temperature on working memory, sustained attention, and reaction time were higher than the effect of each of them individually. As compared with air temperature, noise has a larger effect on working memory, sustained attention, and reaction time in the test configurations. CONCLUSION The cognitive performance effects from noise has one veto power over these effects from low air temperature. Speech sound had more negative effects on subjects' cognitive functions than the typical noise caused by office equipment. The subjective thermal perceptions were also influenced by noise at lower air temperatures.BACKGROUND Passive smoking prevalence is high in Bangladesh. We aimed to explore the association of the theory of planned behavior constructs to reduce the exposure of passive smoking among children in the rural area of Bangladesh. STUDY DESIGN Cross-sectional study. METHODS Overall, 410 adults had been taken at random following a self-administrative questionnaire. Data had been collected from six villages of Munshiganj district of Bangladesh from Jul to Oct 2018. Descriptive statistics were applied to describe socio-demographic characteristics. Inter correlations coefficient was done to observe the correlation, differences between demographic and dependent variables were assessed for significance using the Chi-square or Fisher's exact test as appropriate. Univariate and multivariate logistic regression models were used to investigate the association between the theory of planned behavior constructs and exposure of passive smoking among both smoker and nonsmoker groups. All results were presented as unadjusted and adjusted odds ratio (OR) with 95% confidence intervals (CIs). A P-value ≤0.05 was considered as statistically significant. RESULTS Attitude (OR 0.681, 95% CI 0.498, 0.931) among smoker and intention (OR 0.226, 95% CI 0.081, 0.633) was found statistically significant constructs (P less then 0.001) among non-smoker to reduce the exposure. Additionally, the prevalence of passive smoking exposure was found 36.6% (95% CI 0.32%, 0.41%) on average 40% among males and 28.33% among females. CONCLUSION The theory of planned behavior constructs is useful to reduce the exposure of passive smoking among children, which may be useful in the future to design interventions of controlling passives smoking exposure.BACKGROUND Brucellosis is known as the major zoonotic disease. We aimed to compare the performance of some data-mining models in predicting the monthly brucellosis cases in Iran. STUDY DESIGN Population-based cohort study. METHODS Three data mining techniques including the Support Vector Machine (SVM), Multivariate Adaptive Regression Splines (MARS), and Random Forest (RF) besides to one classic model including Auto-Regressive Integrated Moving Average (ARIMA) was used to predict the monthly incidence of brucellosis in Iran during 2011-2018. We used several criteria (root mean square error (RMSE), mean absolute error (MAE), coefficient of determination (R2) and intra-class correlation coefficient (ICC) for appraising the accuracy of prediction and performance of our models. All analysis was done using free statistical software of R3.4.0 RESULTS Overall 118867 cases (with a mean age of 34.01±1.65 yr) of brucellosis were observed and seven-year incidence rate of brucellosis in Iran was 21.78 (95% CI 21.66, 21.91). The majority of patients (58.84%) were male and 25-29 yr old. The first three provinces with the highest incidence rate of brucellosis included the following; Kurdistan (71.39 per 100000), Lorestan (68.09 per 100000) and Hamadan (56.24 per 100000). CONCLUSION Brucellosis was more common in males, 25-29 aged yr, western provinces and spring months. The disease had a decreasing trend in the last years. MARS model was more appropriate rather than data mining models for prediction of monthly incidence rate of brucellosis.BACKGROUND Violence among adolescents is a global public health concern. There is limited evidence on the effectiveness of anti-bullying interventions in Iran. https://www.selleckchem.com/products/gsk963.html Weaimed to examine the effectiveness of social cognitive theory (SCT)-based intervention on reducing bullying and victimization in elementary school students. STUDY DESIGN A randomized controlled trial. METHODS Eight elementary schools (consisted of 280 students in 5th and 6th grade) from deprived and semi-deprived areas of Kermanshah (west of Iran) were randomly assigned to intervention and control group from 2018 to 2019. Anti-bullying training content appropriate for SCT and sociocultural characteristics were provided to the intervention group including students, parents, teachers and school staff. The measures included SCT constructs, bullying, victimization, and social competence of students. RESULTS At baseline participants of two groups were homogenous in terms of demographic factors except for the type of living with the parent (P=0.040) and outcome variables including SCT constructs and bullying behaviors. The interventions significantly improved SCT constructs, reduced bullying and victimization and increased social competence in the intervention group compared to the control group (P less then 0.001). The difference between outcome expectations in both groups was not significant (P=0.137). CONCLUSION Interventions based on sociocultural characteristics and focuses on SCT theory reduce bullying and victimization behavior. Given the effectiveness and feasibility of these interventions, this theory can be effective to break the bullying cycle and improve social competence.BACKGROUND First year of university is a critical life transition period with an increased probability of taking risky behaviors. We aimed to examine the transitions in risky behaviors in the first year of college in the northwestern Iran using latent transition analysis (LTA). STUDY DESIGN A longitudinal study. METHODS A random sample of 1406 freshmen enrolled in three universities in Tabriz City (the capital city of East Azerbaijan Province, northwestern Iran) were evaluated twice in November 2014 and 2015. A multiple-choice self-administered questionnaire was used to collect data on risky behaviors and demographic characteristics of students. LTA was performed to examine the prevalence and changes in risky behaviors (cigarette and hookah smoking, illicit drug use, alcohol consumption and risky sexual behaviors) among the students. RESULTS The LTA model revealed four interpretable statuses. The prevalence data showed that 77.1%, 12.3%, 8.3% and 2.3% of students were "risk-free", "tobacco user", "sexual risk-taker" and "multiple risk-tacker", respectively in the first assessment.

Findings from this study will also make a broader contribution to the field of CPD, theoretically informing intersections between KMb and CPD and therefore contributing to an integrated science of CPD.
Findings from this study will also make a broader contribution to the field of CPD, theoretically informing intersections between KMb and CPD and therefore contributing to an integrated science of CPD.
Pulmonary vein isolation (PVI) using cryoballoon ablation (CBA) is mainly reserved for patients with drug-refractory or drug-intolerant symptomatic atrial fibrillation. We evaluated a large cohort of patients treated in a real-world setting and examined the safety and efficacy profile of CBA when applied as a first-line treatment for atrial fibrillation.

In total, 249 patients (23% women; 56 ± 13 years; mean left atrial diameter 41 ± 7 mm; 73.5% paroxysmal atrial fibrillation; and 26.5% persistent atrial fibrillation) underwent an index PVI by CBA. Data were collected prospectively in the framework of the 1STOP ClinicalService project, involving 26 Italian cardiology centers.

Median procedure and fluoroscopy times were 90.0 and 21.0 min, respectively. Acute procedural success was 99.8%. https://www.selleckchem.com/products/ly2090314.html Acute/periprocedural complications were observed in seven patients (2.8%), including four transient diaphragmatic paralyses, one pericardial effusion (not requiring any intervention), one transient ischemic attack, and one minor vascular complication. The Kaplan--Meier freedom from atrial fibrillation recurrence was 86.3% at 12 months and 76% at 24 months. Seventeen patients (6.8%) had a repeat catheter ablation procedure during the follow-up period. At last follow-up, 10% of patients were on an anticoagulation therapy, whereas 6.8% were on an antiarrhythmic drug.

In our multicenter real-world experience, PVI by CBA in a first-line atrial fibrillation patient population was well tolerated, effective, and promising. CBA with a PVI strategy can be used to treat patients with paroxysmal and persistent atrial fibrillation with good acute procedural success, short procedure times, and acceptable safety.

clinicaltrials.gov (NCT01007474).
clinicaltrials.gov (NCT01007474).
This report describes the findings of the 2018 Italian Catheter Ablation Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC).

The Italian Catheter Ablation Registry systematically collects data on the ablation procedures performed in Italy. Data collection was retrospective. A standardized questionnaire was completed by participating centres.

We collected data on 15 714 catheter ablation procedures performed in Italy during 2018 in 94 electrophysiology centres. In most centres (75/94, 80%), a single electrophysiology laboratory was available, and a hybrid electrophysiology laboratory was available in 15% (14/94) of centres. In most (93%) centres, at least two electrophysiologists were involved in the catheter ablation procedures. In only 13 out of 94 (14%) electrophysiology laboratories, an anaesthesiologist assists every electrophysiology procedure; in most cases (74/94, 79%), an on-demand anaesthesiology service was available. On-site cardiothoracic surgery was reported in 4by means of a nonfluoroscopic mapping system with a near-zero approach.COronaVIrus Disease-19 (COVID-19) had a huge impact on human health and economy. However, to this date, the effects of the pandemic on the training of young cardiologists are only partially known. To assess the consequences of the pandemic on the education of the cardiologists in training, we performed a 23-item national survey that has been delivered to 1443 Italian cardiologists in training, registered in the database of the Italian Society of Cardiology (SIC). Six hundred and thirty-three cardiologists in training participated in the survey. Ninety-five percent of the respondents affirmed that the training programme has been somewhat stopped or greatly jeopardized by the pandemic. For 61% of the fellows in training (FITs), the pandemic had a negative effect on their education. Moreover, 59% of the respondents believe that they would not be able to fill the gap gained during that period over the rest of their training. A negative impact on the psycho-physical well being has been reported by 86% of the FITs. The COVID-19 pandemic had an unparalleled impact on the education, formation and mental state of the cardiologists in training. Regulatory agencies, universities and politicians should make a great effort in the organization and reorganization of the teaching programs of the cardiologists of tomorrow.We aimed to quantify continuity of care (COC) and investigate its association with health care utilizations and expenditure among patients with diabetes. This was an observational retrospective cohort study using administrative claims database of Iranian Health Insurance Organization for East Azerbaijan Province, Iran. Standard indices of COC were calculated for each patient, and their associations with utilization outcomes were determined by applying general linear regression models. A total of 32 263 patients were included (mean age 60.9 ± 14.5 years; 64% females). Higher levels of COC were associated with a reduced number and spending of all health care service categories.Guidelines for the management of patients with type 2 diabetes mellitus (T2DM) recommend SGLT-2 (sodium-glucose cotransporter 2) inhibitors and GLP-1 RAs (glucagon-like peptide 1 receptor agonists) as second-line agents for patients with, or at risk for, cardiovascular disease. A better understanding of guideline implementation will further the provision of evidence-based health care to patients. Interviews and surveys of clinicians were conducted to understand providers' knowledge, attitudes, and beliefs related to the 2019 American Diabetes Association Standards of Care for T2DM. There was a lack of widespread knowledge of the guidelines and comfort with their use. Clinicians require additional training and education on the efficacy of the new medications and accompanying clinical guidelines.
Disruptive behavior can harm high-quality care and is prevalent in many Western public health systems despite increasing spotlight on it. Comparatively less knowledge about it is available in Asia, a region commonly associated with high-power distance, which may limit its effectiveness in addressing disruptive behavior.

The aim of this study was to develop a comprehensive framework for tackling disruptive behavior among health care professionals in a public health system.

A nationwide cross-sectional study relying on the Nurse-Physician Relationship Survey was conducted in Singapore. Four hundred eighty-six public health care professionals responded.

Two hundred ninety-eight doctors (95.5%) and 163 nurses (93.7%) had witnessed a form of disruptive behavior. Doctors observed disruptive behavior committed by other doctors and nurses much more frequently than did nurses. Doctors made stronger associations between disruptive behavior and negative employee outcomes and between disruptive behavior and negative patient outcomes.

The study results can guide risk stratification to identify medical oncology patients at high risk for 30-day UHR. In addition, the results warrant the need to refine the inpatient assessments and discharge planning, as well as ensure the accurate referral to and allocation of community and outpatient resources so as to reduce the risk of UHR.
The study results can guide risk stratification to identify medical oncology patients at high risk for 30-day UHR. https://www.selleckchem.com/products/ink128.html In addition, the results warrant the need to refine the inpatient assessments and discharge planning, as well as ensure the accurate referral to and allocation of community and outpatient resources so as to reduce the risk of UHR.
To inform improvement in cancer treatment experience and outcomes for people with dementia or milder cognitive impairment. People with dementia, compared to those without, experience more side effects from cancer treatment and have poorer outcomes including poorer survival.

The research was a mixed methods exploratory case study. Each case was a cancer treatment in a person with memory loss, a common symptom of dementia. Observations were conducted in 30 clinic sessions at one cancer centre between September 2014 and February 2015. Thirty-three encounters between people with a memory problem and a staff member were observed and ten consultations recorded. Interviews were conducted with five staff members and six people receiving cancer treatment, five accompanied by their carer. Analysis, informed by hermeneutic phenomenology, enabled the treatment pathway to be mapped and modelled to reveal sites for intervention.

Five potential sites of intervention were identified in the treatment pathway. Five actions at the sites of intervention that may improve patient experience and outcomes include, raising awareness of common problems for people with cognitive impairment receiving cancer treatment, encouraging disclosure of memory problems, staff training to identify memory problems and to know what to do, offering tools and techniques to aid self-management of memory problems, and addressing carer support needs.

Embedding biomedical treatment of cancer within a dementia-friendly psychosocial system may enable safe cancer treatment for a greater number of people with dementia or milder cognitive impairment.
Embedding biomedical treatment of cancer within a dementia-friendly psychosocial system may enable safe cancer treatment for a greater number of people with dementia or milder cognitive impairment.
To analyze diurnal cortisol (COR) rhythms among children with epileptic spasms (ESs) and explore the relationship between endocrine factors, circadian rhythm, and ES.

This study assessed the COR and adrenocorticotropic hormone (ACTH) levels at 0800 and 1600, and COR values at 0000 among children with ESs. Additionally, the etiology of ESs was analyzed. All cases were divided into the following three etiology groups genetic group, structural etiology group, and unknown etiology group. ACTH was administered to 24 patients, who were divided into the positive electroclinical outcome group and negative electroclinical outcome group. All data were analyzed using a two-way repeated measures analysis of variance.

All children showed a COR rhythm. Controls displayed a significantly different COR rhythm from that in the ES group (F
=24.100, p = 0.000). It was observed that the ACTH levels at 0800 (t = -3.720) and 1600 (t=-3.794) and COR levels at 1600 (t = -2.264) and 0000 (t = -4.607) in the ES group were significantly higher than those in the control group (p < 0.05); COR levels at 0800 were significantly lower among individuals in the structural etiology group (F = 3.828, p < 0.05). COR levels at 0800 in the negative electroclinical outcome group (668.30 ± 227.42) nmol/L were higher than those in the positive electroclinical outcome group (462.25 ± 249.71) nmol/L.

Our results suggest that the change in COR rhythm is an important pathophysiological characteristic of ESs, suggesting that hypothalamus-pituitary-adrenal axis dysfunction possibly leads to the different manifestations of ESs.
Our results suggest that the change in COR rhythm is an important pathophysiological characteristic of ESs, suggesting that hypothalamus-pituitary-adrenal axis dysfunction possibly leads to the different manifestations of ESs.
Most seizures during pregnancy occur in women who already have epilepsy. Rarely, some women may have their first seizure during pregnancy. The purpose of this study was to investigate the clinical features and pregnancy outcomes in women with new-onset epilepsy during pregnancy.

112 pregnant women with epilepsy were prospectively evaluated at the Education - Therapeutic Clinic of the Azerbaijan Medical University, in the neurological and maternity departments of the Clinical Medical Center in Baku over a six-year period. Women were regularly followed by a neurologist and obstetrician till the end of pregnancy. To determine the recurrence of seizures during the pregnancy and after delivery, the women were followed up at least once per three months for a one year period after delivery. Delivery and perinatal outcomes were compared with those of 277 healthy women in the control group (without epilepsy and without registering chronic diseases).

Of the 112 pregnant women with epilepsy, 12 (10.7%) had their fs were not increased compared to women with epilepsy before pregnancy. Neonatal hypoxia was associated with delivery by cesarean section.Match probabilities calculated during the evaluation of DNA evidence profiles rely on appropriate values of the population structure quantity θ. NGS-based methods will enhance forensic identification and with the transformation to such methods comes the need to facilitate NGS-based population genetics analysis. If NGS data are to be used for match probabilities there needs to be a way to accommodate population structure, which requires values for θ for those data. Such estimates have not been available. This study assesses population structure for sequence-based data using a relatively new approach applied to STR data over 27 loci in five different geographic groups. Matching proportions between individuals or groups are used to obtain locus-specific θ estimates as well as estimates per geographic group and a global measure. The results demonstrate similar effects of sequencing data on θ estimates compared to what has been seen for CE-based results.