La cardiologie est un domaine spécialisé qui utilise des techniques invasives et non invasives pour traiter une gamme de maladies cardiaques.

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Copyright © 2019 SETOX & Institute of Experimental Pharmacology and Toxicology, SASc.Earthworms are important organisms in soil communities and are known for sustaining the life of the soil. They are used as a model organism in environmental risk assessment of chemicals and soil toxicology. Soil provides physical and nutritive support to agriculture system by regulating biogeochemical cycles, nutrient cycle, waste degradation, organic matter degradation etc. The biggest threat to soil health are pesticides and synthetic chemicals including fertilizers. Earthworms are most severely hit by these xenobiotic compounds leading to a sizeable reduction of their population and adversely affecting soil fertility. Earthworms are incredible soil organisms playing a crucial role in maintaining soil health. Pesticides used in crop management are known to be most over-purchased and irrationally used soil toxicants, simultaneously, used insecticides contribute to a quantum of damage to earthworms and other non-target organisms. LC50 and LD50 studies revealed that earthworms are highly susceptible to insecticides causing immobility, rigidity and also show a significant effect on biomass reduction, growth and reproduction by disrupting various physiological activities leading to loss of earthworm population and soil biodiversity. Copyright © 2019 SETOX & Institute of Experimental Pharmacology and Toxicology, SASc.Aluminium (Al) is frequently accessible to animal and human populations to the extent that intoxications may occur. Intake of Al is by inhalation of aerosols or particles, ingestion of food, water and medicaments, skin contact, vaccination, dialysis and infusions. Toxic actions of Al induce oxidative stress, immunologic alterations, genotoxicity, pro-inflammatory effect, peptide denaturation or transformation, enzymatic dysfunction, metabolic derangement, amyloidogenesis, membrane perturbation, iron dyshomeostasis, apoptosis, necrosis and dysplasia. The pathological conditions associated with Al toxicosis are desquamative interstitial pneumonia, pulmonary alveolar proteinosis, granulomas, granulomatosis and fibrosis, toxic myocarditis, thrombosis and ischemic stroke, granulomatous enteritis, Crohn's disease, inflammatory bowel diseases, anemia, Alzheimer's disease, dementia, sclerosis, autism, macrophagic myofasciitis, osteomalacia, oligospermia and infertility, hepatorenal disease, breast cancer and cyst, pancreatitis, pancreatic necrosis and diabetes mellitus. The review provides a broad overview of Al toxicosis as a background for sustained investigations of the toxicology of Al compounds of public health importance. Copyright © 2019 SETOX & Institute of Experimental Pharmacology and Toxicology, SASc.Fungal communities play a crucial role in maintaining the health of managed and natural soil environments, which directly or indirectly affect the properties of plants and other soil inhabitants. As part of a Citizen Science Project initiated by the Westerdijk Fungal Biodiversity Institute and the Utrecht University Museum, which aimed to describe novel fungal species from Dutch garden soil, the diversity of Didymellaceae, which is one of the largest families in the Dothideomycetes was investigated. A preliminary analysis of the ITS and LSU sequences from the obtained isolates allowed the identification of 148 strains belonging to the family. Based on a multi-locus phylogeny of a combined ITS, LSU, rpb2 and tub2 alignment, and morphological characteristics, 20 different species were identified in nine genera, namely Ascochyta, Calophoma, Didymella, Juxtiphoma, Nothophoma, Paraboeremia, Phomatodes, Stagonosporopsis, and Xenodidymella. Several isolates confirmed to be ubiquitous plant pathogens or endophytes were for the first time identified from soil, such as Ascochyta syringae, Calophoma clematidis-rectae, and Paraboeremia litseae. Furthermore, one new genus and 12 novel species were described from soil Ascochyta benningiorum sp. nov., Didymella degraaffiae sp. nov., D. kooimaniorum sp. nov., Juxtiphoma kolkmaniorum sp. nov., Nothophoma brennandiae sp. nov., Paraboeremia rekkeri sp. nov., P. truiniorum sp. nov., Stagonosporopsis stuijvenbergii sp. nov., S. weymaniae sp. nov., Vandijckomycella joseae gen. nov. et sp. nov., V. snoekiae sp. nov., and Xenodidymella weymaniae sp. nov. From the results of this study, soil was revealed to be a rich substrate for members of Didymellaceae, several of which were previously known only from diseased or apparently healthy plant hosts. Lingwei Hou, Margarita Hernández-Restrepo, Johannes Zacharias Groenewald, Lei Cai, Pedro W. https://www.selleckchem.com/products/pd-1-pd-l1-inhibitor-3.html Crous.Trametes is a globally distributed genus of white-rot polypores and well sampled in temperate and boreal areas. However, the diversity, taxonomy, and phylogenetic positions of Trametes spp. are poorly known in tropical Africa. This study aims at documenting the diversity of Trametes species in Benin (tropical Africa) and their phylogenetic positions with a focus on the T. elegans species complex. Therefore, we collected specimens of Trametes from different forest types across Benin. To infer phylogenetic relationships between Trametes species, we investigated sequences of five gene regions and added available sequences from GenBank. Using Maximum likelihood and Bayesian phylogeny inference methods, we found eight supported species clades. For the T. elegans species complex, we re-establish the name Trametes palisotii for species previously known as T. elegans in tropical Africa. Furthermore, we propose Trametes parvispora as a species new to science and provide the description of this species. Our molecular phylogeny of Trametes with a focus on tropical Benin contributes to taxonomic clarity of an important wood-decay fungal genus, which is the basis for biodiversity assessments of Trametes in the tropics. Boris Armel Olou, Franz-Sebastian Krah, Meike Piepenbring, Nourou Soulemane Yorou, Ewald Langer.Golden jackal (Canis aureus) expansion in the last decades has triggered research interest in Europe. However, jackal phylogeny and taxonomy are still controversial. Morphometric studies in Europe found differences between Dalmatian and the other European jackals. Recent genetic studies revealed that African and Eurasian golden jackals are distinct species. Moreover, large Canis aureus lupaster may be a cryptic subspecies of the African golden jackal. Although genetic studies suggest changes in Canis aureus taxonomy, morphological and morphometric studies are still needed. The present study proposes the first comprehensive analysis on a wide scale of golden jackal skull morphometry. Extensive morphometric data of jackal skulls from Europe (including a very large Bulgarian sample), Asia Minor, and North Africa were analysed, by applying recently developed statistical tools, to address the following questions (i) is there geographic variation in skull size and shape among populations from Europe, Anatolia and the Caucasus?, (ii) is the jackal population from the Dalmatian coast different?, and (iii) is there a clear distinction between the Eurasian golden jackal (Canis aureus) and the African wolf (Canis lupaster sensu lato), and among populations of African wolves as well? Principal component analysis and linear discriminant analysis were applied on the standardized and log-transformed ratios of the original measurements to clearly separate specimens by shape and size.

COVID-19 is a disease with no proven pharmaceutical intervention and no proven vaccine. In such circumstances, prevention is all we have. The role of handwashing in the prevention of communicable diseases has been known for over a century, yet it remains severely neglected as a public health investment, to be periodically re-discovered during pandemic-scale infections. Over https://www.selleckchem.com/products/abbv-2222.html of the global population has no access to a handwashing station in the home; for many low-income countries this proportion rises to over 50%. In other instances, the water is unaffordable or the supply has been shut off on account of unpaid bills. But when there is no water in the home or yard, or no mechanism for delivering enough water, good hand-washing is extremely difficult. Well before COVID-19, global cost-benefit analyses of water and sanitation investments, with benefits measured in time-savings as well as health, showed significant net benefits in all sub-regions of the developing world. This Viewpoint paper argues that, in the current crisis and its aftermath, it is imperative for governments and donors to prioritize and generously fund affordable, reliable, and accessible water services in underserved regions of the world. More than ever before, this is a foundational investment for health, dignity and development.Developing countries are highly vulnerable to the COVID-19 pandemic, in part due to the lack of international support for ensuring progress towards the 17 Sustainable Development Goals (SDGs). Yet the mounting financial burden faced by all countries means that additional support is unlikely to be forthcoming in the near future. #link# It is critical that developing countries find innovative policy mechanisms to achieve sustainability and development aims in a cost-effective manner. This requires identifying affordable policies that can yield immediate progress towards several SDGs together and aligns economic incentives for longer term sustainable development. We identify three policies that meet these criteria a fossil fuel subsidy swap to fund clean energy investments and dissemination of renewable energy in rural areas; reallocating irrigation subsidies to improve water supply, sanitation and wastewater infrastructure; and a tropical carbon tax, which is a levy on fossil fuels that funds natural climate solutions. link2 Such innovative and cost-effective policy mechanisms do not require substantial external support, and they foster greater progress towards achieving the SDGs in poorer economies.This note presents three important facts on the COVID-19 pandemic and 22 developing countries, namely those in the Pacific. First, social protection systems are less common in the Pacific than in the rest of the world, meaning the region is not particularly well equipped to deal with the sharp decline in economic activity associated with the disease and standard policy responses (e.g., lockdowns) without plunging a large share of the population into poverty. Second, aggressive travel restrictions and effective domestic policy responses have spared many Pacific countries from the worst impacts of COVID-19. Ten countries have not had a single confirmed case. link3 The experience of the region thus offers helpful lessons for other developing countries in keeping the crisis at bay. Third, the relative success of Australia and New Zealand in managing the virus provides an opportunity to pilot and test in the region what a carefully managed pathway to allow the tourism, migration, and remittances, that many countries depend on, to begin flowing again. Against its relative success, the Pacific has a unique opportunity to show the world how to safely emerge from the current crisis and address underlying vulnerabilities before the next one.In the decade since the 2008 global food crisis, West African countries have made efforts to raise domestic rice production and to make the region self-sufficient. Today, West Africa produces nearly two-thirds of Africa's rice. The region's rice import dependency has fallen from nearly half of local consumption in 2010 to about 30%. In spite of this improvement, the region remains the world's second largest rice importer. The situation of Benin, Burkina Fasso, Gambia and Niger remains challenging with rice import dependency still exceeding 70%. Production in some countries has fallen even below the 2010 level due to civil strife, climatic changes and macroeconomic difficulties. Countries of the region, on average, allocate less than 5% of their budget to agriculture, less than half the share committed in the Maputo Agreement. The Covid-19 outbreak and corresponding preventive lockdowns have posed a new challenge as food supply chains were stretched; production, transportation and consumption fell sharply; and household income was affected. In addition, closure of frontiers and temporary trade disruption in major Asian rice exporters has led to increase in rice prices in the international market. In late April, rice futures rose to reach a level not surpassed since 2011. This threatens to further aggravate an already fragile food security situation in the region. The crisis again points to the need for greater efforts at the national and international level to achieve food security. West African countries will need to enhance public spending on agriculture with a greater focus on measures aimed at improving rice productivity.The COVID-19 outbreak has infected millions of people across the world, caused hundreds of thousands of deaths, and collapsed national economies. Recognizing the importance of handwashing in preventing the spread of COVID-19, concerns have arisen about the condition of millions of Africans who lack access to hygiene facilities and clean water services. This paper compiles evidence from the WHO-UNICEF data to show the health disparities that limit the capacity of African countries to effectively address the COVID-19 disease along with recommendations for addressing the challenge.Emerging evidence supports the intuitive link between chronic health conditions associated with air pollution and the vulnerability of individuals and communities to COVID-19. Poor air quality already imposes a highly significant public health burden in Northwest India, with pollution levels spiking to hazardous levels in November and early December when rice crop residues are burned. The urgency of curtailing the COVID-19 pandemic and mitigating a potential resurgence later in the year provides even more justification for accelerating efforts to dramatically reduce open agricultural burning in India.In this article I argue that while the COVID-19 outbreak is at its early stages in the Gaza Strip, the Palestinian coastal enclave is particularly vulnerable to its effects - not least due to the multiplicity of existing development challenges that have resulted from an ongoing Israeli and Egyptian-imposed blockade. With the economy at a standstill, the Palestinian governing authority has limited financial resources to (re)build key sanitation, hygiene, waste treatment and water supply infrastructure. These (infrastructural) inadequacies, while already a public health concern before the onset of the pandemic, now renders Gaza particularly vulnerable to the spread of viruses and diseases. Additionally, the limited movement of goods because of the siege has led to an acute shortage of medical supplies and equipment that are essential for combating a pandemic. Nonetheless, the COVID-19 outbreak is also "unique" in that it presents Gaza with a crisis that has little to do with the hostilities that define the politics of Israel-Palestine. Yet, the potential of a widespread outbreak also lays bare to the development challenges that Gaza faces as a result of the conflict. This, I conclude, provides an opportunity for the donor community to, under pretext of combating the pandemic, remedy some of the consequences of the conflict and siege without having to contend with the (political) stigma of doing so.The COVID-19 pandemic is increasing the need for international food assistance, and disrupting the supply and delivery of food assistance. A series of unprecedented shocks is straining the capacity of food assistance organizations to reach vulnerable populations. We discuss how the COVID-19 pandemic is affecting the demand and the supply of international food assistance, and we propose three policy changes that can keep food flowing to those in need. First, donor countries can prioritize humanitarian spending in aid-allocation decisions. Second, governments can exempt food assistance from trade barriers that impede procurement (export restrictions) and delivery (import tariffs). Third, donor countries can allow flexibility for implementing agencies by untying food assistance from domestic procurement and shipping restrictions. All of these proposals are regulatory changes that can be made without requiring increased spending. These options are particularly relevant now because donor-country governments are entering economic recessions, and foreign aid budgets will be constrained.South Korea's response is considered by many as one the most effective models against COVID-19. The average number of new cases per day fell to 6.4 in the first week of May and currently 90% of all confirmed cases have fully recovered after a massive outbreak in February 29. First, South Korea has flattened the curve of COVID-19 by combining testing, early isolation, and free treatment of positive cases combined with digital technologies without taking to "lockdown" measures. Second, South Korea has been holding press briefings twice a day and disclosed all information on COVID-19 to the public in an open and transparent manner. Third, South Korea has worked to secure the civic participation and voluntary engagement of citizens and businesses. The South Korean approach to COVID-19 may be difficult to emulate even for countries like the U.S. and U.K., but provides important policy implications for developing countries and needs for strengthening three core competencies against the outbreak of an epidemic digital technology, efficient health governance, and civic partnership. It is a great challenge for developing countries to fight alone against COVID-19. As such, the international community should work to strengthen these core competencies accordingly.The globalized world economy has been affected by the COVID-19 pandemic since early February 2020. In the midst of this global public health crisis, a prompt review of the counterinsurgencies that have occurred in different jurisdictions is helpful. This article examines the experience of Hong Kong (HKSAR), which successfully limited its number of confirmed cases to approximately 1100 until early June 2020. Considering the limited actions that the government has taken against the pandemic, we emphasize the prominent role of Hong Kong's civil society through highlighting the strong and spontaneous mobilization of its local communities originating from their experiences during the SARS outbreak in 2003 and the social unrest in 2019, as well as their doubts regarding the pandemic assessments and recommendations of the HKSAR and WHO authorities. This article suggests that the influence of civil society should not be overlooked in the context of pandemic management.

immunolabeled RGC density (4623.53 ± 179.48/0.17mm
). https://www.selleckchem.com/products/gsk-lsd1-2hcl.html As compared to the normal control (the ratio of β-catenin/VEGF to β-actin was set as 1 in the Sham group), the β-catenin/VEGF protein level significantly (P < 0.001) increased after retinal ischemia and when pre-ischemic intravitreous vehicle (Vehicle+IR = 1.64 ± 0.14/7.67 ± 2.57) was carried out. However, these elevations were significantly (P = 0.02) attenuated by treatment with emodin 20 μM (Emo20 + IR = 1.00 ± 0.19/1.23 ± 0.44).

The present results suggest that emodin might protect against retinal ischemia insulted neurons such as RGCs by significantly downregulating the upregulation of β-catenin/VEGF protein that occurs during ischemia.
The present results suggest that emodin might protect against retinal ischemia insulted neurons such as RGCs by significantly downregulating the upregulation of β-catenin/VEGF protein that occurs during ischemia.
Behavioural and structural factors related to sex work, place female sex workers (FSWs) at high risk of maternal mortality and morbidity (MMM), with a large portion due to unintended pregnancies and abortions. In the African context where MMM is the highest in the world, understanding the frequency and determinants of pregnancy and abortion among FSWs is important in order to meet their sexual and reproductive health needs.

Data from two Beninese cross-sectional surveys among FSWs aged 18+ (2013, N= 450; 2016, N= 504) were merged. We first performed exploratory univariate analyses to identify factors associated with pregnancy and abortion (p< 0.20) using Generalized Estimating Equations with Poisson regression and robust variance. Multivariate analyses first included all variables identified in the univariate models and backward selection (p≤ 0.05) was used to generate the final models.

Median age was 39 years (N= 866). The proportion of FSWs reporting at least one pregnancy during sex work practice was 16.4%, of whom 42.3% had more than one. Most pregnancies ended with an abortion (67.6%). In multivariate analyses, younger age, longer duration in sex work, previous HIV testing, having a boyfriend and not using condoms with him were significantly (p< 0.05) associated with more pregnancies.

One FSW out of five had at least one pregnancy during her sex work practice. Most of those pregnancies, regardless of their origin, ended with an abortion. Improving access to various forms of contraception and safe abortion is the key to reducing unintended pregnancies and consequently, MMM among FSWs in Benin.
One FSW out of five had at least one pregnancy during her sex work practice. Most of those pregnancies, regardless of their origin, ended with an abortion. Improving access to various forms of contraception and safe abortion is the key to reducing unintended pregnancies and consequently, MMM among FSWs in Benin.
Little is known about the presentation, help seeking behaviour for breast cancer in Singapore. Nor was there a study exploring the experience of patients in their breast cancer journey.

A qualitative interview study with thematic analysis, conducted with 36 patients.

There is no clear pattern of presentation for breast cancer by cancer stage at diagnosis, age and ethnicity in the cancer journey of this group of patients. Patients were diagnosed with early to advanced stages cancer regardless of when they presented or took up treatment in their cancer journey. The reasons patients sought medical attention also did not appear to differ between the stages of cancer diagnosed, ethnic and age. Without setting a measure to define early and late presentation, we found that women shared similar experience in their breast cancer journey, regardless of age, ethnicity and stage of cancer at diagnosis. Poor knowledge of breast cancer (symptoms and causes); few practised regular BSE; denial of symptom; fear of hospiique to perform BSE, are critical and urgent to address the rising breast cancer incidence in the country.
A measure of breast cancer presentation - that accounts for the patient's experience in the cancer journey, the time interval and tumour biology - that is meaningful to patients, clinicians and researchers is needed. For research on late and delayed presentation, details on BSE practice - how often, when and was it done correctly - will improve the accuracy of time delay interval. For the public, concerted efforts to improve knowledge of breast cancer, survival and prognosis for early-diagnosed cancer, and the importance of regular and correct technique to perform BSE, are critical and urgent to address the rising breast cancer incidence in the country.
To study mean core to peripheral temperature difference (CPTD) and the mean lactate levels over the first 6 h of admission to hospital, as indicators of prognosis in critically ill children.

A prospective observational study in a tertiary level Pediatrics ICU in Delhi, India. Seventy eight paediatric patients from 1 month to 12 years were studied. Children with physical trauma, post-surgical patients and patients with peripheral vascular disease were excluded. Core temperature (skin over temporal artery) to peripheral temperature (big toe) difference was measured repeatedly every minute over 6 h and mean of temperature difference was calculated. Pediatric Risk of Mortality (PRISM) II, lactate clearance and mean lactate levels during that time were also studied. In-hospital mortality was used as the outcome measure.

Mean temperature difference During the first 6 h after admission the mean temperature difference was 9.37 ± 2 °C in those who died and 3.71 ± 2.27 °C in those who survived (p< 0.0001). Theiatric ICU. The mean lactate during the first 6 h of Pediatric ICU admission is a better index of prognosis than the lactate clearance over the same time period. They may be used as components of a scoring system to predict mortality.
In low-income countries breast cancer awareness (BCA) is essential to reduce the proportion of advanced stage presentations of breast cancer. There is a lack of studies using multivariable techniques to explore factors related to BCA in low-income countries. The objective of this study was to identify to what extent women in Fiji and Kashmir, India have BCA and practice breast self-examination (BSE) as well as factors associated with BCA and BSE.

A survey of women aged ≥18 years was conducted in Fiji and Kashmir, India to assess BCA and rates of BSE. Comparison between Fiji and Kashmir was done using student's t-test for continuous data and chi-square for binary data. Factors associated with BCA and BSE were analysed using a multivariable logistic regression for Fiji and Kashmir separately.

Data were collected from 399 and 1982 women in Kashmir and Fiji, respectively. Of 1968 women in Fiji 57% were deemed to have an acceptable BCA compared to only 7.3% of 395 women in Kashmir. Having some education was associated with having BCA with an odds ratio of 4.

This paper examines the effects of China's foreign direct investment (FDI) on the carbon emissions of its domestic economy and the Belt and Road countries (BRCs). Total inward FDI into China as a host country shows a pollution reducing effect in the western and eastern regions while that in the central region remains unchanged. But China's outward FDI particularly from its eastern region reduces pollution in China. This suggests that China could be exporting carbon emissions via its FDI in the BRCs. The effects on BRCs' pollution from China's FDI is however different depending on the country's level of development. China's FDI was found to have no effect on high and upper middle income BRCs; a decreasing effect on low income BRCs; and an increasing effect on lower middle income BRCs. Evidence shows that China needs to consider a mix of policies to manage its inward and outward FDI to ensure its move to a low carbon economy benefits its own regional development and the BRCs by not contributing to increased carbon emissions.In the context of tremendously promoting bioenergy utilization, regional suitability for industrial development of biomass power generation is a critical factor when deploying region-specific strategies. An integrated framework is developed incorporating resource potential, development demands and development conditions to evaluate the suitability for regional industrial development of power generation utilizing agricultural bioresources. Twelve indicators reflecting local resource, environmental and socioeconomic features are used to measure the suitability of 31 provincial regions in China. An improved matter-element extension model combined with the entropy weight method is adopted to attain holistic and hierarchical suitability ranks. https://www.selleckchem.com/products/climbazole.html The results reveal that the distribution of holistic suitability ranks among regions is imbalanced with the eastern regions presenting more advantages compared with the western regions. Three regions belonging to Rank I (optimum) are Henan, Shandong and Xinjiang. Hainan, Tibet, Qinghai are classified into Rank V (unsuited). Moreover, there are great differences in the limiting factors of the suitability among regions. Resource potential is a limiting factor for Beijing, Shanghai, Fujian, Hainan and Guizhou; Development demands refrain Fujian, Guangxi and Yunnan; Tianjin and Ningxia are limited by development conditions. Tibet and Qinghai have the worst performance on each criterion. The results and region-targeted policy recommendations can provide insights for bioenergy utilization development in accordance with local conditions closely.Weighting scheme definition represents an important step in assessment of adaptive capacity to climate change with indicator approach since it defines the trade-offs among indicators or components and can be source of uncertainty. This study aims to assess smallholder farmers' adaptive capacity to climate change by using a mixed weighting scheme that reflect farmers' perceived importance of adaptive capacity components to inform policy makers. To achieve that objective, the sustainable livelihood framework was adopted and indicator approach was used for the assessment. The mixed weighting scheme were defined by using both equal weights and experts judgement methods during the assessment process. The mixed weighting scheme index is compared to the case where equal weights are applied in the assessment process and an uncertainty analysis was performed on relative standard deviation through a Monte Carlo simulation. Primary Data were collected from 450 farmers in two communities in northern Benin with a structured questionnaire and through focus groups discussion. The results show that smallholder farmers in both communities do not have the same perceived importance of adaptive capacity components. The index scores show that farmers have in majority low adaptive capacity. When weighted product aggregation method is used, there is more uncertainty related to the index computed with the mixed weighting scheme, but it leads to the same characterisation when compared with the index computed with the equal weights. It is recommended that mixed weighting scheme should be preferred for the assessment of adaptive capacity and weighted product aggregation method should be used.Huntington's disease (HD) is a neurodegenerative disease characterized by prominent loss of neurons in the striatum and cortex. Traditionally research in HD has focused on brain changes as they cause progressive motor dysfunction, cognitive decline and psychiatric disorders. The discovery that huntingtin protein (HTT) and its mutated form (mHTT) are expressed not only in the brain but also in different organs and tissues paved the way for the hypothesis that HD might affect regions beyond the central nervous system (CNS). Besides pathological deposition of mHTT, other mechanisms, including inflammation, seem to underlie HD pathogenesis and progression. Altered inflammation can be evidenced even before the onset of classical symptoms of HD. Herein, we will discuss current pre-clinical and clinical evidence on immune/inflammatory changes in peripheral organs during HD development and progression. The understanding of the impact of inflammation on peripheral organs may open new venues for the development of novel therapeutic targets in HD.Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) commonly complicated by cognitive impairment. Unfortunately, no medical therapy has been proved to improve cognitive problems in these patients. This meta-analysis investigated the effectiveness of different categories of drugs on the minimal assessment of cognitive function in MS (MACFIMS)-related tasks outcome in MS patients. To this end, a systematic evaluation was conducted using PubMed, Google Scholar, and Scopus databases. Among a total of 128 publications, 31 studies met our inclusion criteria, and 22 included in the meta-analysis. We found that symbol digit modalities test (SDMT), paced auditory serial addition test (PASAT), controlled oral word association test (COWAT), and California verbal learning test (CVLT) were the most frequently reported tasks in included studies. The frequently reported drugs were classified into five main groups of acetylcholine esterase inhibitors, CNS stimulants, fampridine, herbal remedies, and miscellaneous.