The description of a new species and revision of the Angolan Panaspis contributes to a better understanding of the true species richness of the Angolan herpetofauna, as well as to understanding the major biogeographic patterns of the region. A key to Angolan Panaspis species is also presented.The spider genus Ixchela Huber 2000, is comprised of 22 species distributed from north-eastern Mexico to Central America, including the two new species described herein from Mexico Ixchela panchovillai sp. nov. and Ixchela zapatai sp. nov., both from the state of Oaxaca and described for both sexes. DNA barcoding utilizing mitochondrial cytochrome c oxidase subunit 1 (COI) and morphology were used for species delimitation. Molecular analyses and species delimitation included four methods 1) corrected p-distances under neighbor-joining (NJ), 2) general mixed yule coalescent model (GMYC), 3) automatic barcode gap discovery (ABGD), and 4) Poisson tree processes (bPTP). All molecular methods and morphology were consistent in delimiting and recognizing the two new species describing herein. The average inter-specific genetic distance (p-distance) within the genus Ixchela is 12%. Ixchela panchovillai sp. nov. is closely related in the NJ analysis with I. placida, with an average p-distance of 7.9%, whereas I. zapatai sp. nov. is closely related to I. taxco, with an average p-distance of 8.4% between both species. Additionally, identification keys for males and females of the genus Ixchela are presented.The feather mite family Gabuciniidae currently includes 16 genera and approximately 65 described species associated with birds of nine orders, with the greatest diversity on Accipitriformes. In this study, 11 new species are described from the following hosts Aetacarus accipiter sp. nov. from the Bicolored Hawk Accipiter bicolor (Vieillot, 1817) (Accipitriformes Accipitridae), Capitolichus campoflicker sp. nov. from the Campo Flicker Colaptes campestris (Vieillot, 1818) (Piciformes Picidae), Coraciacarus cabure sp. nov. from the Barred Forest-falcon Micrastur ruficollis (Vieillot, 1817) (Falconiformes Falconidae), Coraciacarus peixefrito sp. nov. from the Pheasant Cuckoo Dromococcyx phasianellus (Spix, 1824) (Cuculiformes Cuculidae), Gabucinia neotropica sp. nov. from the Curl-crested Jay Cyanocorax cristatellus (Temminck, 1823) (type host) and C. chrysops (Vieillot, 1818) (Passeriformes Corvidae), Hieracolichus caboclo sp. nov. from the Savanna Hawk Buteogallus meridionalis (Latham, 1790) (Accipitriformes Aciids, which is not surprising considering the vast bird fauna of this country, and especially since most avian species from Brazil have yet to be investigated for their feather mites.Four species of Alnetoidia Dlabola, 1958 s. str. are described and illustrated. Among them, Alnetoidia (Alnetoidia) jejudoensis sp. nov. is new to science and Alnetoidia (Alnetoidia) straminea Anufriev, 1972 is newly recorded for the Korean fauna. A key to the Korean species is provided.A new species of cynipid herb gall wasp, Aulacidea turcica Azmaz Katılmış sp. n., (Hymenoptera Cynipidae Aulacideini) is described from Turkey. Based on morphological characters, A. turcica belongs to the genus Aulacidea. Both sexual females and males of this species are known and the females induce galls on the stem of Digitalis ferruginea. This is the first record of host use in the genus Digitalis and possibly the family Plantaginaceae by a species of Aulacidea. Five species belonging to Aulacideini were previously known from Turkey. SEM images and data on the diagnosis, distribution, and biology of the new species are provided.Examination of type specimens and topotypic material is often a necessary step to ascertain the validity of a species. Consequently, solid knowledge about type series, type locality and type depository is critical. In this paper, we provide a thorough review of the mosquito species originally described from specimens collected in French Guiana, with specific emphasis on the location of the current depositories of type material, the composition of type series and the delimitation of type localities. Information already published about the mosquito type material from French Guiana was gathered and efforts were made to ascertain the current location of their depositories. This investigation made it possible to locate a large part of the existing type material and to provide corrected information on type series and type localities, therefore providing a strong basis for future taxonomic research on mosquitoes. The type locality of Culex (Culex) pseudojanthinosoma Senevet Abonnenc is corrected from French Guiana to Africa, and this species is synonymized with Culex (Culex) duttoni Theobald.Chimarra gangtokensis sp. nov. is added as a new species from Sikkim. With this addition of a new species, the genus is represented in India by 53 species. Furthermore, Polyplectropus admin Malicky Chantaramongkol 1993, Hydropsyche briareus Malicky Chantaramongkol 2000, Cheumatopsyche globosa (Ulmer 1910), and Cheumatopsyche chryseis Malicky Chantaramongkol 1997 are reported for the first time from India. Also, Chimarra kailishchandrai Malicky 1997a, Cheumatopsyche bhatrapura Malicky 1979, and Oecetis asmada Malicky 1979 are reported for the first time from North Andaman Island, India.Ceratophyus amdoensis Král Jákl, new species from Gansu and Qinghai Provinces of China is described, illustrated and compared with its congeners so far known from China and adjacent countries. A key to identification of males of Chinese species of Ceratophyus Fischer von Waldheim, 1824 is provided. Ceratophyus polyceros (Pallas, 1771) is excluded from the fauna of China. First province records of C. dauricus (Jekel, 1866) from Hebei (China) and Hentiy (Mongolia) and first province records of C. sinicus Zunino, 1973 from Hebei, Ningxia and Shaanxi (China) are reported. Distribution of five species so far known from China is summarized and mapped.Madagassoconnus Franz and Oneila Peringuey were described as genera, but their diagnoses largely overlap with that of Euconnus. Results of detailed morphological studies justify placing Madagassoconnus and Oneila as subgenera of Euconnus. https://www.selleckchem.com/products/gsk3787.html Madagassoconnus differs from most of previously reviewed subgenera of Euconnus in minor characters, mainly in tarsomeres III and IV forming elongate anteroventral lobes. Oneila differs from other subgenera mainly in strongly and uniquely modified antennomeres VII and VIII, or only VII, in males; other characters are almost identical as those in Tetramelus Motschulsky, Paratetramelus Franz and Heteroconnus Franz. However, results of preliminary phylogenetic analyses are still inconclusive, and a conservative approach is adopted to treat Madagassoconnus and Oneila as valid names, pending further study. Previous (and the only) redescription of the type species of Madagassoconnus, Cyrtoscydmus kolbei L.W. Schaufuss, is discussed as likely based on misidentified specimens not conspecific with the type material.

There were 53 requests in the first survey and 106 in the second survey. These requests were divided into seven subthemes compensation, staffing, information, facilities, leave time, PCR tests and equitable treatment. The theme on gratitude had two subthemes information and emotional support, and material support. The fears and desires of healthcare workers included two types of uncertainty-related concerns, and requests were very different across the two surveys.

It is important to apply a balance of information to help staff adjust to their new work environment, as well as support to minimise the burden of infection and impact on their families.
It is important to apply a balance of information to help staff adjust to their new work environment, as well as support to minimise the burden of infection and impact on their families.
Psychosocial factors predict recovery in patients with spinal pain. Several of these factors are modifiable, such as depression and anxiety. However, primary care physiotherapists who typically manage these patients indicate that they do not feel sufficiently competent and equipped to address these factors optimally. We developed an eHealth intervention with a focus on pain education and behavioural activation to support physiotherapists in managing psychosocial factors in patients with spinal pain. This paper describes the protocol for a pragmatic randomised clinical trial, which evaluates the effectiveness of this eHealth intervention blended with physiotherapy compared with physiotherapy alone.

Participants with non-specific low back pain and/or neck pain for at least 6 weeks who also have psychosocial risk factors associated with the development or maintenance of persistent pain will be recruited in a pragmatic multicentre cluster randomised clinical trial. https://www.selleckchem.com/products/5-cholesten-3beta-ol-7-one.html The experimental intervention consists of physiotherapy blended with six online modules of pain education and behavioural activation. The control intervention consists of usual care physiotherapy. The primary outcomes are disability (Oswestry Disability Index for low back pain and Neck Disability Index for neck pain) and perceived effect (Global Perceived Effect). Outcomes will be assessed at baseline and at 2, 6 and 12 months after baseline. The results will be analysed using linear mixed models.

The study is approved by the Medical Ethical Committee of VU Medical Center Amsterdam, The Netherlands (2017.286). Results will be reported in peer-reviewed journals, at national and international conferences, and in diverse media to share the findings with patients, clinicians and the public.

NL 5941; The Netherlands Trial Register.
NL 5941; The Netherlands Trial Register.
The rapid influx of patients with COVID-19 to intensive care at a rate that exceeds pre-existing staff capacity has required the rapid development of innovative redeployment and training strategies, which considered patient care and infection control. The aim of this study was to provide a detailed understanding of redeployment and training during the first year of the COVID-19 pandemic by capturing and considering the merit of the strategies enlisted and the experiences and needs of redeployed healthcare workers (HCWs).

The review involved a systematic search of key terms related to intensive care AND training AND redeployment AND healthcare workers within nine databases (Medline, CINAHL, PsychINFO, MedRxiv, Web of Science, The Health Management Consortium database, Social Science Research Network, OpenGrey and TRIP), which took place on 16 July 2021. Analysis consisted of a synthesis of quantitative study outputs and framework-based thematic analysis of qualitative study outputs and grey literature. The to tackle these challenges, which are relevant to inform the development of targeted and adaptative training and redeployment plans considering the needs of HCWs.
In patients with newly diagnosed atrial fibrillation (AF), do baseline risk factors and stroke prevention strategies account for the geographically diverse outcomes.

Global Anticoagulant Registry in the FIELD-Atrial Fibrillation is a prospective multinational non-interventional registry of patients with newly diagnosed AF (n=52 018 patients).

Investigator sites (n=1317) were representative of the care settings/locations in each of the 35 participating countries. Treatment decisions were all determined by the local responsible clinicians.

The patients (18 years and over) with newly diagnosed AF had at least 1 investigator-determined stroke risk factor and patients were not required to meet specific thresholds of risk score for anticoagulant treatment.

Observed 1-year event rates and risk-standardised rates were derived.

Rates of death, non-haemorrhagic stroke/systemic embolism and major bleeding varied more than three-to-four fold across countries even after adjustment for baseline factors and antithrombotic treatments. Rates of anticoagulation and antithrombotic treatment varied widely. Patients from countries with the highest rates of cardiovascular mortality and stroke were among the least likely to receive oral anticoagulants. Beyond anticoagulant treatment, variations in the treatment of comorbidities and lifestyle factors may have contributed to the variations in outcomes. Countries with the lowest healthcare Access and Quality indices (India, Ukraine, Argentina, Brazil) had the highest risk-standardised mortality.

The variability in outcomes across countries for patients with newly diagnosed AF is not accounted for by baseline characteristics and antithrombotic treatments. Residual mortality rates were correlated with Healthcare Access and Quality indices. The findings suggest the management of patients with AF needs to not only address guideline indicated and sustained anticoagulation, but also the treatment of comorbidities and lifestyle factors.

NCT01090362.
NCT01090362.
Modifiable physical activity (PA) plays an important role in dyslipidaemia risk in middle-aged women with sleep problems, especially perimenopausal women. We aimed to explore the joint effects of sleep and PA on the risk of dyslipidaemia in women aged 45-55 years, and the extent to which PA moderated the effect of sleep on the risk of dyslipidaemia.

A cross-sectional study.

This study was based on the survey of Chronic Disease and Nutrition Monitoring in Adults in Inner Mongolia in 2015.

721 women aged 45-55 years were included.

PA was measured by the Global Physical Activity Questionnaire. Sleep was measured by questionnaire formulated by the Chinese Center for Disease Control and Prevention. Multivariate logistic regression analyses were performed to determine the joint effects of sleep and PA on dyslipidaemia risk. OR and 95% CI were reported.

Among all participants, 60.6% had sleep problems, 29.0% had low PA and 41.1% had dyslipidaemia. Women with sleep problems had higher dyslipidaemia risk tmen aged 45-55 years, the joint effects of self-reported sleep and PA on dyslipidaemia risk were more marked for sleep than for PA. Modifiable PA is a widely accessible and effective intervention to reduce the dyslipidaemia risk in women with sleep problems, particularly among perimenopausal women.
Acute lymphoblastic leukaemia (ALL) is the most common form of cancer in children. Although treatment methods have improved and resulted in significant improvement of survival and reduction in late effects and late mortality risk, the health-related quality of life (HRQOL) of survivors might be affected. To introduce new interventions in clinical practice with the potential to support positive HRQOL outcomes, more knowledge is needed on how HRQOL in this group is constructed and stimulated. The purpose of this study is to investigate how HRQOL is affected in adults treated for paediatric ALL, in a long-term perspective and possible factors influencing this relationship.

This cohort of young adult ALL survivors allows for investigations of factors influencing HRQOL outcomes on a national level. Eligible participants are obtained from the Swedish Childhood Cancer quality registry. Data collection includes both a follow-up of data collected in 2012 (n=224) and recruitment of new eligible participants to the emination of study results will take place through research articles and reports to the national patient organisation and the national network for consultancy nurses for this target group and to the working group for the Swedish national long-term care programme for childhood cancer. Results will also reach practical application within the follow-up clinic for adult childhood cancer survivors at Sahlgrenska Hospital in Gothenburg.
Insomnia is a novel pathogen for type 2 diabetes mellitus (T2DM). However, mechanisms linking insomnia and T2DM are poorly understood. In this study, we apply a network Mendelian randomization (MR) framework to determine the causal association between insomnia and T2DM and identify the potential mediators, including overweight (body mass index (BMI), waist-to-hip ratio, and body fat percentage) and glycometabolism (HbA1c, fasting blood glucose, and fasting blood insulin).

We use the MR framework to detect effect estimates of the insomnia-T2DM, insomnia-mediator, and mediator-T2DM associations. A mediator between insomnia and T2DM is established if MR studies in all 3 steps prove causal associations.

In the Inverse variance weighted method, the results show that insomnia will increase the T2DM risk (OR 1.142; 95% CI 1.072 to 1.216; p=0.000), without heterogeneity nor horizontal pleiotropy, strongly suggesting that genetically predicted insomnia has a causal association with T2DM. Besides, our MR analysis provides strong evidence that insomnia is causally associated with BMI and body fat percentage. There is also suggestive evidence of an association between insomnia and the waist-to-hip ratio. At the same time, our results indicate that insomnia is not causally associated with glycometabolism. Higher BMI, waist-to-hip ratio, and body fat percentage levels are strongly associated with increased risk of T2DM.

Genetically predicted insomnia has a causal association with T2DM. Being overweight (especially BMI and body fat percentage) mediates the causal pathway from insomnia to T2DM.
Genetically predicted insomnia has a causal association with T2DM. Being overweight (especially BMI and body fat percentage) mediates the causal pathway from insomnia to T2DM.Tisagenlecleucel is safe and effective for adults with pretreated relapsed/refractory follicular lymphoma (FL).Slide-DNA-seq spatially resolves genetic aberrations in intact tumor sections.Lactobacillus reuteri and its metabolite, reuterin, are reduced in colon cancer and inhibit its growth.Integrated single-cell analysis of T cells reveals landscapes of T-cell states in different cancers.Spinal cord injury (SCI) is a devastating condition. Splenectomy may play a protective role in the development of SCI. However, little is known about whether the timing of splenectomy affects the outcome after SCI. Investigation into splenectomy after SCI would provide insight into how the timing can be selected following SCI to improve neurologic outcomes. Rats were randomized into a sham group, a nonsplenectomized group (NonSPX), four splenectomized groups with the surgery performed immediately, 6 h, 12 h, and 24 h after SCI (SPX0, SPX6, SPX12, and SPX24, respectively). Rats were subjected to severe contusive SCI at the level of the third thoracic vertebra. At different time points following SCI, Basso, Beattie, and Bresnahan (BBB) score was used to assess the recovery of injury. The animals in each group were randomly selected for tissue collection at days 3, 14, and 28 after surgery. Then, immunohistochemistry of immunologic cells was performed and inflammatory mediators were determined. Our study showed that splenectomy within 6 h after SCI improved BBB scores as compared with splenectomy more than 12 h after SCI, and decrease the immune cell responses to SCI.

CONCLUSIONS These results indicated that 3OC6-HSL enhanced plant salt tolerance and ABA-dependent and ABA-independent signal pathways and SOS signaling might be involved in the induction of salt resistance by 3OC6-HSL in plants. Our data provide a new insight into the plant-microbe inter-communication.This study uses qualitative interviews with leaders of 34 mental health clinics in the context of a statewide rollout of clinical and business innovations to explore how clinics first learn about innovations and which external sources of information they access. Clinic leaders reported accessing information about innovations mainly from government agencies, professional associations, peer organizations, and research literature. Leaders mentioned an average of two external sources of information. There was evidence of variation in how leaders accessed information and how information about innovations was communicated within clinics. Findings have implications for improving dissemination of information about innovations in mental health systems.The Editors-in-Chief have retracted this article [1] following an investigation by the University of Maryland. The institution found that in Figures 1B and 1D, the cell lines are different and all published histograms show SEMA4D mRNA level whereas Excel data have two histograms showing SEMA4D expression and two histograms showing VEGF expression. In Figure 2B, the metadata for one image shows different treatment conditions than those reported in the article. The published image labelled "VEGF + VEGFR-2 shRNA" has a metadata label of S4d-plexinB1 shRNA2". In Figure 2E, statistical significance was shown in the published figure for four comparisons, but upon recalculation, one comparison noted as significant was not. In Figure 6A, the lower left image is labelled "VEGF shRNA" in the published figure, but the metadata label is "S4DshRNA-HN121-20X". In Figure 6C, specifically, within columns 2-4, for each antibody used for immunocytochemistry, the three images have been swapped so that the original images do not match the shRNA labels in the figure (the labels for the two antibodies were correct). In Figure 7D, the first published image is labelled as "IgG" in the paper, but the metadata show a label of "Restore (V+S).tif". https://www.selleckchem.com/products/azd9291.html The third published image has a label of "anti-VEGF IgG", and the metadata show a label of "con sh.tif". Due to these errors, the Editors-in-Chief have found that the results are no longer reliable.BACKGROUND In Canadian medicine faculties, an average of 2.3% of the medical curriculum is dedicated to musculoskeletal problems with a focus on orthopedic conditions. The goal of this descriptive study was to assess the educational preferences in rheumatology of family medicine residents and to identify their preferred methods of learning. METHODS From September 2017 to December 2017, two hundred and thirty-six first- and second-year family medicine residents from Université Laval were asked to complete an electronic anonymous survey assessing their confidence in doing different rheumatology tasks. They were also consulted on their favorite methods of learning and their preferred periods throughout their medical cursus to learn the different skills related to rheumatology. RESULTS Eighty-five family medicine residents completed the survey. The residents were rather confident when evaluating mono-arthritis but less confident for oligo/polyarthritis and even less confident with connective tissue diseases. The family medicine residents mentioned preferring traditional lecture classes and clinical cases. They wanted to learn the majority of rheumatology education during medical school training. As residents, they wanted only small capsules, seminars, or memory aids. Interestingly, men preferred learning rheumatology skills during the residency, whereas women preferred learning it in medical school. CONCLUSION The lack of confidence of family medicine residents when evaluating systemic inflammatory diseases compared to mechanical musculoskeletal problems highlights the importance of rheumatology teaching through general medical training and through family medicine residency.Key Points• Family medicine residents are less confident when evaluating systemic inflammatory diseases than musculoskeletal disorders.• Family medicine residents prefer traditional lecture classes and clinical cases.• Family medicine residents prefer learning rheumatology during medical school training.OBJECTIVE The aim of the present study is to investigate the clinical features of patients with Behcet's disease (BD) in Mongolia. METHODS Patients were identified and examined from six medical institutions in Mongolia from January 2015 to January 2019. BD was diagnosed according to the diagnostic criteria for BD established by the International Study Group. RESULTS There were sixty-five patients (22 males and 43 females) recoded, the ratio of 11.95, with a marked female predominance. The age of disease onset was 22.2 ± 10.0 (mean ± SD), ranging from 11 to 66 years old. Oral aphthous ulcers, ocular lesions, skin lesions, genital ulcers, pathergy test positivity, articular lesions, superficial vasculitis, deep vein thrombosis, and epididymitis (male only) were observed in 100.0%, 63.1%, 81.5%, 89.2%, 7.7%, 86.2%, 32.3%, 4.6%, and 13.6% of the patients, respectively. The incidence of poor visual prognosis, ≤ 20/200, was significantly higher in males than in females (31.8 vs. 9.3%, incidence rate ratio 4.55 (95% CI 1.16-17.82), p  less then  0.05). The pathergy test was positive only in 7.7% of cases and only in female subjects. Nasal mucous ulcers were frequently seen in 55.4% of patients that may also be attributed to the environmental conditions of Mongolia. Headache was observed 76.9% of patients in this study. CONCLUSIONS Clinical manifestations of BD in Mongolia are presented for the first time. The visual prognosis was significantly worse in males. Nasal mucous membrane ulcers and recurrent headaches were frequent among Mongolian patients with BD.Key Points• First results of the examination of the clinical features of Behcet's disease patients in Mongolia.• Nasal ulcerations and recurrent headaches are frequent symptoms in Mongolia Behcet's disease patients, potentially attributed to climate.• Male Behcet's disease patients in Mongolia have a significantly worse prognosis for eye-related complications and vision.

In this context, vitamin D or its analogues have been used to treat both skin and bone lesions in NF1 patients, alone or combined with other therapeutic agents. Here we provide an overview of vitamin D, its characteristic nutritional properties relevant for health benefits and its role in NF1 disorder. We focus on preclinical and clinical studies that demonstrated the clinical correlation between vitamin D status and NF1 disease, thus providing important insights into disease pathogenesis and new opportunities for targeted therapy.
Few studies have been performed to identify objective indicators for the selection of therapeutic donkeys or to assess their welfare during animal-assisted interventions (AAIs) Objective This study aimed to evaluate the response to the ethological test and the modifications of physiological parameters in donkeys subjected to AAI sessions.

Thirteen donkeys were subjected to a behavioral evaluation during an AAI session. Heart rate, heart rate variability, and root mean square of successive difference values were detected.

Statistically significant changes in the tested parameters were observed during AAI sessions.

In donkeys, there was a neurovegetative involvement during AAI sessions. Our data give a contribution to the evaluation of donkey welfare during AAIs.
In donkeys, there was a neurovegetative involvement during AAI sessions. Our data give a contribution to the evaluation of donkey welfare during AAIs.This investigation focused on an episode of chronic mortality observed in juvenile Huso huso sturgeons. The examined subjects underwent pathological, microbiological, molecular, and chemical investigations. Grossly severe body shape deformities, epaxial muscle softening, and multifocal ulcerative dermatitis were the main observed findings. The more constant histopathologic findings were moderate to severe rarefaction and disorganization of the lymphohematopoietic lymphoid tissues, myofiber degeneration, atrophy and interstitial edema of skeletal epaxial muscles, and degeneration and atrophy of the gangliar neurons close to the myofibers. Chemical investigations showed a lower selenium concentration in affected animals, suggesting nutritional myopathy. Other manifestations were nephrocalcinosis and splenic vessel wall hyalinosis. Septicemia due to bacteria such as Aeromonas veronii, Shewanella putrefaciens, Citrobacter freundii, Chryseobacterium sp., and pigmented hyphae were found. No major sturgeon viral pathogens were detected by classical methods. Next-generation sequencing (NGS) analysis confirmed the absence of viral pathogens, with the exception of herpesvirus, at the order level; also, the presence of Aeromonas veronii and Shewanella putrefaciens was confirmed at the family level by the metagenomic classification of NGS data. In the absence of a primary yet undetected biological cause, it is supposed that environmental stressors, including nutritional imbalances, may have led to immune system impairment, facilitating the entry of opportunistic bacteria and mycotic hyphae.The single-hop star-of-stars topology in low-power and wide-area networks (LPWAN) exhibits reliability and substandard coverage issues, especially in urban areas where line-of-sight (LoS) communication is difficult to achieve. Moreover, LPWAN trade-off the data rate to achieve longer coverage, preventing other end-devices from using the time resource. Locating other gateways is uneconomical as it requires infrastructure, such as the internet and a power connection. In this study, we propose a forwarding scheme with a relay to increase LPWAN coverage and reliability while not degrading the network's capacity. A relay tends to incur unnecessary forwarding that degrades the network capacity unless proper countermeasure is prepared. Our works, namely opportunistic and on-demand network coding (OODC), minimize unnecessary forwarding and make good use of multiple-receiving relays. Network coding is also applied in the relay for better transmission efficiency and reliability simultaneously. Because network coding occurs header overhead, we perform a header compression technique to counter it. According to our simulation result, our method shows better reliability than fixed path forwarding. In an adaptive data rate settings, the OODC achieves a 92% packet delivery ratio (PDR), whereas a fixed-path forwarding only achieves an 84% PDR.Nutrition and health claims should be truthful and not misleading. We aimed to determine the use of nutrition and health claims in packaged foods sold in Mongolia and examine their credibility. A cross-sectional study examined the label information of 1723 products sold in marketplaces in Ulaanbaatar, Mongolia. The claim data were analysed descriptively. In the absence of national regulations, the credibility of the nutrition claims was examined by using the Codex Alimentarius guidelines, while the credibility of the health claims was assessed by using the European Union (EU) Regulations (EC) No 1924/2006. Nutritional quality of products bearing claims was determined by nutrient profiling. Approximately 10% (n = 175) of products carried at least one health claim and 9% (n = 149) carried nutrition claims. The credibility of nutrition and health claims was very low. One-third of nutrition claims (33.7%, n = 97) were deemed credible, by having complete and accurate information on the content of the claimed nutrient/s. Only a few claims would be permitted in the EU countries by complying with the EU regulations. Approximately half of the products with nutrition claims and 40% of products with health claims were classified as less healthy products. The majority of nutrition and health claims on food products sold in Mongolia were judged as non-credible, and many of these claims were on unhealthy products. Rigorous and clear regulations are needed to prevent negative impacts of claims on food choices and consumption, and nutrition transition in Mongolia.Guinea worm disease (GWD) is a neglected tropical disease that was targeted for eradication several decades ago because of its limited geographical distribution, predictable seasonality, straightforward diagnosis, and exclusive infection of humans. However, a growing body of evidence challenges this last attribute and suggests that GWD can affect both humans and animal populations. The One Health approach emphasizes the relatedness of human, animal, and environmental health. We reviewed epidemiological evidence that could support the utility of a One Health approach for GWD control in the six countries that have reported human GWD cases since 2015-Angola, Cameroon, Chad, Ethiopia, Mali, and South Sudan. Human GWD cases have dramatically declined, but recent years have seen a gradual increase in human case counts, cases in new geographies, and a rapidly growing number of animal infections. Taken together, these suggest a need for an adjusted approach for eradicating GWD using a framework rooted in One Health, dedicated to improving disease surveillance and in animals; pinpointing the dominant routes of infection in animals; elucidating the disease burden in animals; determining transmission risk factors among animals and from animals to humans; and identifying practical ways to foster horizontal and multidisciplinary approaches.Plants that synthesize bioactive compounds that have high antioxidant value and elicitation offer a reliable in vitro technique to produce important nutraceutical compounds. The objective of this study is to promote the biosynthesis of these phenolic compounds on a large scale using elicitors in date palm cell suspension culture. Elicitors such as pectin, yeast extract (YE), salicylic acid (SA), cadmium chloride (CdCl2), and silver nitrate (AgNO3) at 50, 100, and 200 mg/L concentrations are used. The effects of elicitors on cell culture were determined in terms of biomass [packed cell volume (PCV), fresh and dry weight], antioxidant activity, and phenolic compounds (catechin, caffeic acid, kaempferol, apigenin) were determined using high-performance liquid chromatography (HPLC). Results revealed that enhanced PCV (12.3%), total phenolic content [317.9 ± 28.7 mg gallic acid equivalents (GAE)/100 g of dry weight (DW)], and radical scavenging activity (86.0 ± 4.5%) were obtained in the 50 mg/L SA treated cell culture of Murashige and Skoog (MS) medium. The accumulation of optimum catechin (26.6 ± 1.3 µg/g DW), caffeic acid (31.4 ± 3.8 µg/g DW), and kaempferol (13.6 ± 1.6 µg/g DW) was found in the 50 mg/L SA-treated culture when compared to the control. These outcomes could be of great importance in the nutraceutical and agronomic industries.Nowadays, due to the advances and the increasing implementation of the autonomous braking systems in vehicles, the non-collision accident is expected to become more common than a crash when a sudden stop happens. The most common injury in this kind of accident is whiplash or cervical injury since the neck has high sensitivity to sharp deceleration. To date, biomechanical research has usually been developed inside laboratories and does not entirely represent real conditions (e.g., restraint systems or surroundings of the experiment). With the aim of knowing the possible neck effects and consequences of an automatic emergency braking inside an autonomous bus, a surface electromyography (sEMG) system built by low-cost elements and developed by us, in tandem with other devices, such as accelerometers or cameras, were used. Moreover, thanks to the collaboration of 18 participants, it was possible to study the non-collision effects in two different scenarios (braking test in which the passenger is seated and looking ahead while talking with somebody in front of him (BT1) and, a second braking test where the passenger used a smartphone (BT2) and nobody is seated in front of him talking to him). The aim was to assess the sEMG neck response in the most common situations when somebody uses some kind of transport in order to conclude which environments are riskier regarding a possible cervical injury.Tumor heterogeneity is considered to be a hallmark of glioblastoma (GBM). https://www.selleckchem.com/products/BMS-794833.html Only more recently, it has become apparent that GBM is not only heterogeneous between patients (intertumoral heterogeneity) but more importantly, also within individual patients (intratumoral heterogeneity). In this study, we focused on assessing intratumoral heterogeneity. For this purpose, the heterogeneity of 38 treatment-naïve GBM was characterized by immunohistochemistry. Perceptible areas were rated for ALDH1A3, EGFR, GFAP, Iba1, Olig2, p53, and Mib1. By clustering methods, two distinct groups similar to subtypes described in literature were detected. The classical subtype featured a strong EGFR and Olig2 positivity, whereas the mesenchymal subtype displayed a strong ALDH1A3 expression and a high fraction of Iba1-positive microglia. 18 tumors exhibited both subtypes and were classified as "subtype-heterogeneous", whereas the areas of the other tumors were all assigned to the same cluster and named "subtype-dominant". Results of epigenomic analyses corroborated these findings. Strikingly, the subtype-heterogeneous tumors showed a clearly shorter overall survival compared to subtype-dominant tumors. Furthermore, 21 corresponding pairs of primary and recurrent GBM were compared, showing a dominance of the mesenchymal subtype in the recurrent tumors. Our study confirms the prognostic impact of intratumoral heterogeneity in GBM, and more importantly, makes this hallmark assessable by routine diagnostics.

Extant scales related to measuring the sensory aspect of a brand from the consumer's perspective are typically either too abstract or too concrete. Thus, this study aimed to create a scale with a medium degree of abstraction by which to measure sensory brand experience. This entailed a process of scale development and validation. In study 1, we conducted a qualitative study to explore possible dimensions and items using semi-structured interviews. Several dimensions and items were proposed by combining findings from a literature review and the consumer interviews. In study 2, we examined the items and preliminarily tested the validity of the scale. The results show that, according to our scale, most of the brands considered could be differentiated in terms of the sensory experience they generate. The scale is thus deemed to have potential as a useful tool by which to evaluate the sensory quality of brands. In study 3, we further examined the items, verified the dimensions, tested the reliability and validity of the scale, and formally presented a final version of the scale. This final version comprises three dimensions and 10 items. The three dimensions represent, respectively, three important factors that may influence consumers' perceptions and evaluations of the sensory quality of brands the volume of sensory brand stimuli, the uniqueness of sensory brand stimuli, and the consistency between sensory brand stimuli and consumer. The scale's reliability and validity are found to be satisfactory. Future research can thus employ the scale to assess the sensory experience of various brands, and even to rank brands accordingly. While the present study in the Chinese context is expected to provide valuable insights into the brand experience and sensory branding literature, further research could be conducted to validate the scale in other geographical and cultural contexts.In this study, the extension of theory of planned behavior was developed to evaluate the effects of antecedents that influence consumers' intention to buy green products. The effect of nine determinants (i.e., individual benefits, social benefits, willingness-to-pay, environmental responsibility, e-word-of-mouth, values, self-competence, convenience, and environmental literacy) of the green wave on Taiwanese consumers was empirically tested by examining their perception of social responsibility through theory of planned behavior. #link# Except for consumer subjective norms, the remaining factors exhibited significant positive correlations with the planned behavior, implying that the voluntary participation aspect of the green wave is considerably more critical than its mandatory social pressure. To diffuse this green wave more effectively, the Taiwanese government should encourage consumers to easily capture the detailed impact of the green wave on the society and allow consumers to use word-of-mouth marketing for the creation of relational value to improve their quality of life.That social desirability might be a confounder of people's survey responses regarding environmental actions has been discussed for a long time. To produce evidence for or against this assumption, we conducted meta-analyses of correlations between social desirability scales and self-reports of environmentally relevant behaviors, intentions, and (broadly defined) attitudes, based on data from 29 previously published papers. The pooled correlations with social desirability are generally small, ranging from 0.06 to 0.11 (0.08-0.13 when correcting for measurement error attenuation). However, our results do not lead to the conclusion that social desirability can be completely disregarded by environmental psychologists as a potential confounder. For example, we found evidence of substantial heterogeneity across studies, so the effect of social desirability may be more pronounced in specific cases. Continued attention to social desirability bias is needed to fully understand its possible subtle effects.Henrich et al. (2010) highlighted the necessity of broadening the range of regions for cross-cultural investigation in their seminal paper "The weirdest people in the world." They criticize the current psychological framework for relying dominantly on American undergraduate students for their participant database, and state that there is a risk associated with investigating human nature by focusing solely on a unique population. This line of research has, over the past 30 years, successfully demonstrated the diversity of human cognition. However, https://www.selleckchem.com/products/CI-1040-(PD184352).html is true that there are still only a limited number of studies that have extended their geographical regions of research outside of G7 (Canada, France, Germany, Italy, Japan, United Kingdom, and United States) and G20 countries (Argentina, Australia, Brazil, China, India, Indonesia, Mexico, Russia, Saudi Arabia, South Africa, South Korea, Turkey, EU countries, and the above G7 countries). In order to fully examine the issue of culture and cognition, we maintain that the field of psychology must extend its research globally. In this paper, we will briefly discuss the history of cross-cultural research in the 1960s which can be seen as the beginning of addressing the above concerns, and review some contemporary empirical studies which took over their 1960s predecessors' mission. Here we address three strengths of extending the geographical scope to advance cultural psychology. In the second half of the paper, we will introduce our preliminary study conducted in Mongolia as a sample case study to demonstrate a way of administering cultural psychological research outside of the existing research field. We will then discuss implications of this line of research, and provide tips on how to open a new research site.Background and Aim Drumming requires excellent motor control and temporal coordination. Deploying specific muscle activation patterns may help achieve these requirements. Muscle activation patterns that involve reciprocal contraction of antagonist muscles are particularly favorable as they enable a high level of muscular economy while maintaining performance. In contrast, simultaneous contraction of antagonist muscles is an inefficient muscle activation pattern. In drumming, co-contraction can lead to increased movement variability and greater fatigue over time. In this study we examine how muscle activation patterns develop with increased drumming expertise. Methods Eleven expert drummers (ED) and eleven amateur drummers (AD) were recorded using 3D motion capture while performing five different uni-manual and bi-manual repetitive drumming tasks across different tempi. link2 Electromyography was used to record muscle activation of wrist flexor and extensor muscles. Results Findings indicate that reduced co-contraction resulted in more even drumming performance. Co-contraction also increased in extremely slow and very high tempi. Furthermore, regardless of task or tempo, muscle co-contraction was decreased in participants with higher levels of expertise. In addition to anti-phasic activity of wrist flexor and extensor muscles, expert drummers exhibited a flexor dominance, suggesting more efficient usage of rebound. Conclusion Taken together, we found that higher levels of drumming expertise go hand in hand with specific muscle activation patterns that can be linked to more precise and efficient drumming performance.Player motivation is a key research area within games research, with the aim of understanding how the motivation of players is related to their experience and behavior in the game. We present the results of a cross-sectional study with data from 750 players of League of Legends, a popular Multiplayer Online Battle Arena game. Based on the motivational regulations posited by Self-Determination Theory and Latent Profile Analysis, we identify four distinct motivational profiles, which differ with regards to player experience and, to a lesser extent, in-game behavior. While the more self-determined profiles "Intrinsic" and "Autonomous" report mainly positive experience-related outcomes, a considerable part of the player base does not. Players of the "Amotivated" and "External" profile derive less enjoyment, experience more negative affect and tension, and score lower on vitality, indicating game engagement that is potentially detrimental to players' well-being. With regards to game metrics, minor differences in the rate of assists in unranked matches and performance indicators were observed between profiles. This strengthens the notion that differences in experiences are not necessarily reflected in differences in behavioral game metrics. Our findings provide insights into the interplay of player motivation, experience, and in-game behavior, contributing to a more nuanced understanding of player-computer interaction.Increasing evidence suggests that language switching is a distinct form of bilingual language control that engages cognitive control. The most relevant and widely discussed framework is the Adaptive Control Hypothesis. This theoretical framework identifies language switching to be a key aspect of bilingual language control. It proposes that bilinguals' engagement in three different types of interactional contexts (single-language context, dual-language context, and dense code-switching context) confers adaptive effects on cognitive control processes. These contexts differ in the presence of both languages and how language control is exercised. The model makes predictions about behavioral outcomes associated with these contexts. This study is a novel attempt to test for the model's assumptions, predictions, and its interactional contexts. It seeks to examine the relationship between language switching behaviors, reported bilingual interactional contexts, and verbal and non-verbal cognitive control through thisontexts. Current findings reveal the complex interaction of language switching with distinct domains and cognitive control processes. This study is significant in testing an influential bilingual language control model.The survival of businesses in the market often hinges on contributions of the business owner's household members. Partners of the self-employed as well as their children may, for example, provide emotional support but also cheap and flexible labor. Although the household composition of self-employed individuals has been analyzed in many earlier studies, little is known about what happens to the self-employed individual and his or her business when one separates from a life partner. We argue that separation from a life partner has profound financial and social consequences for the business owner. Specifically, we propose that a decrease in household income and social functioning (which is the degree of interference with social activities due to mental and/or physical problems) after separation from the life partner may lead to an exit from self-employment. link3 Our empirical analysis draws on data from the longitudinal HILDA (Household, Income and Labour Dynamics in Australia) survey, for the period 2002-2017. Baseing that decreased household income and levels of social functioning are important mechanisms through which separation from the life partner is related to exit from self-employment.