Several tests were performed to check the in vitro and in vivo biocompatibility of the membrane. A highly connected homogeneous network was obtained due to the appropriate orientation of a hard segment and soft segment in the synthesized membrane. Mechanical property analysis indicates the membrane has a strength of 5.15MPa and strain 124%. The membrane showed high hemocompatibility, no cytotoxicity on peripheral blood mononuclear cell, and susceptible to degradation in simulated body fluid solution. Antimicrobial activity assessment has shown promising results against clinically significant bacteria. Primary hypopharyngeal cell growth on the PU membrane revealed the cytocompatibility and subcutaneous implantation on the back of Wistar rats were given in vivo biocompatibility of the membrane. Therefore, the synthesized material can be considered as a potential candidate for a hypopharyngeal tissue engineering application.
Diagnosis of ascending thoracic aortic aneurysm (ATAA) is based on the measurement of the maximum aortic diameter, but size is not a good predictor of the risk of adverse events. There is growing interest in the development of novel image-derived risk strategies to improve patient risk management towards a highly individualized level. In this study, the feasibility and efficacy of deep learning for the automatic segmentation of ATAAs was investigated using UNet, ENet, and ERFNet techniques. Specifically, CT angiography done on 72 patients with ATAAs and different valve morphology (i.e., tricuspid aortic valve, TAV, and bicuspid aortic valve, BAV) were semi-automatically segmented with Mimics software (Materialize NV, Leuven, Belgium), and then used for training of the tested deep learning models. The segmentation performance in terms of accuracy and time inference were compared using several parameters. All deep learning models reported a dice score higher than 88%, suggesting a good agreement between predicted and manual ATAA segmentation. We found that the ENet and UNet are more accurate than ERFNet, with the ENet much faster than UNet. This study demonstrated that deep learning models can rapidly segment and quantify the 3D geometry of ATAAs with high accuracy, thereby facilitating the expansion into clinical workflow of personalized approach to the management of patients with ATAAs.Precise delineation of the ischemic lesion from unimodal Magnetic Resonance Imaging (MRI) is a challenging task due to the subtle intensity difference between the lesion and normal tissues. Hence, multispectral MRI modalities are used for characterizing the properties of brain tissues. Traditional lesion detection methods rely on extracting significant hand-engineered features to differentiate normal and abnormal brain tissues. But the identification of those discriminating features is quite complex, as the degree of differentiation varies according to each modality. This can be addressed well by Convolutional Neural Networks (CNN) which supports automatic feature extraction. It is capable of learning the global features from images effectively for image classification. But it loses the context of local information among the pixels that need to be retained for segmentation. Also, it must provide more emphasis on the features of the lesion region for precise reconstruction. The major contribution of this work is the integration of attention mechanism with a Fully Convolutional Network (FCN) to segment ischemic lesion. This attention model is applied to learn and concentrate only on salient features of the lesion region by suppressing the details of other regions. https://www.selleckchem.com/products/oxythiamine-chloride-hydrochloride.html Hence the proposed FCN with attention mechanism was able to segment ischemic lesion of varying size and shape. To study the effectiveness of attention mechanism, various experiments were carried out on ISLES 2015 dataset and a mean dice coefficient of 0.7535 was obtained. Experimental results indicate that there is an improvement of 5% compared to the existing works.
Social distancing by working-from-home is an effective measure to decrease the spread of COVID-19. However, this new work pattern could also affect the well-being of workers. Therefore, the aim of the study was to study the magnitude of occupational health problems and lifestyle changes among workers who have only recently started working from home.

A cross-sectional study was conducted using online self-administered questionnaires during the coronavirus disease 2019 pandemic in the Bangkok metropolitan area, Thailand. The participants were from any organization that allowed working from home. The demographic dataincluding the analysis of the characteristics of working from home, the occurrence of occupational health problems, and the lifestyle changes caused by working from home were analyzed.

A total of 869 workers were included as study participants. The highest prevalence of physical health problems among all workers was identified to be weight gain at a rate of 40.97% (95% confidence interval=37.69-44.24), and the highest prevalence of psychosocial problems was identified to be cabin fever at a rate of 31.28% (95% confidence interval=26.66-35.90%) among full-time working-from-home workers. The health effects that were significantly related to the intensity of working from home (
for trends <0.05), either positively or negatively, included body weight changes, ergonomic problems, indoor environmental problems, and psychosocial problems. Meanwhile, the lifestyle changes related to work intensity included eating pattern, sleep habits, and exercise.

Working from home can affect workers' well-being in various aspects. Hence, occupational health providers must prepare for risk prevention and health promotion in this "new normal" working life pattern and for future pandemics.
Working from home can affect workers' well-being in various aspects. Hence, occupational health providers must prepare for risk prevention and health promotion in this "new normal" working life pattern and for future pandemics.Date palm (Phoenix dactylifera L.) inflorescence rot caused by Mauginiella scaettae poses a serious threat to date palm in Morocco. The present study aims to determine the antifungal activity of five plant extracts against M. scaettae, including Acacia cyanophylla, Cupressus atlantica, Eucalyptus torquata, Nerium oleander, and Schinus molle and link this effect to their content in phenolics and flavonoids, as well as their antioxidant properties. Plant extracts exhibited significant discrepancies regarding their antifungal activity (p less then 0.05). The extracts of E. torquata and C. atlantica had the strongest and dose-dependent manner inhibitory effect against mycelial growth and spore germination. E. torquata and S. molle caused the greatest sporulation reductions of about 88.05% and 36.11%, respectively. In addition, there were significant differences among the examined plant extracts with respect to their total polyphenols (14.52-76.68 mg GAE/g DW), flavonoids (8.75-57.78 g RE/100 g DW), and antioxidant properties as measured by TEAC (74.

The interaction of trend, beauty, interior design, structure, boardgames and indulgence delight visitors younger and old. https://linde-hassing.thoughtlanes.net/prada-luxurious-clothing-for-men-and-women Prada clothes and accessories have been described as both basic and eccentric, frumpy however hip, marked by an ambiguous techno-retro sensibility. On the one hand, Prada's fashion is modern, drawing on northern Italian traditions of discreet class and fine craftsmanship.
For the subsequent 20 years, Miuccia worked tirelessly to reinvent Prada as a status symbol, beginning with a line of baggage in 1979. The brand began solely producing a restricted amount of things in each assortment, to create an ongoing demand and search for the “exclusive” items. In 1989, the primary ready-to-wear assortment of Prada clothes made its debut, containing strains of coveted Prada dresses, skirts and different gadgets. The 90s saw the model finally breaking icon standing, as Prada became essentially the most anticipated and revered model in ready-to-wear fashion. Today, Prada maintains over forty locations worldwide, and as of 2016 became available through the web retailer Net-A-Porter.

Buy Prada Clothing Online Men 268 Merchandise

Luisa stored the enterprise afloat for nearly 20 years after Mario’s dying in 1958. Discover the choice of backpacks in different sizes and the long-lasting Prada Re-Nylon belt bag. Originally created in 1997 for the Luna Rossa crew, the enduring Prada America's Cup sneakers return, offered in their original silhouette and made of leather and technical cloth. Collars are AccessoriesThe entrance of the first model at Prada's fall menswear show in Milan stole the attendees' attention with a distinctive item on his neck. As for the eye stealer, the sharp wing-like removable collar was snapped out with pink fuzzy angora particulars. Orders acquired after December 12th with commonplace delivery will not be delivered before December twenty fourth.
Thrust into her new position as a businesswoman, the introspective Prada found her match when she met Patrizio Bertelli, a headstrong Tuscan leather-goods manufacturer who had his own manufacturing facility. With Bertelli’s business-shark brain and Prada’s prescience for what the public didn’t yet comprehend it craved, the brand’s revival wasn’t lengthy in coming. The shock product that set every thing in movement was an innocuous black backpack, made from the identical fine nylon cloth that Prada’s grandfather had used as a protective cowl on his steamer trunks (and the Italian army had used for parachutes). Ready-to-wear had been launched in 1988, and as a outcome of the company’s fortunes rose, Prada started to establish herself as a proficient clothing designer—in truth, the one to observe.

1000+ Catchy Clothing Brand Name Ideas In 2023 + Free Logo

This one is a re-edition of the brand’s iconic silhouette from 2005. The historical past behind the 'YSL’ Cassandra line is an fascinating one - it’s really named after Adolphe Mouron Cassandre, the person who designed the long-lasting 'YSL’ logo seen right here on the bag’s front. Taylor Swift Style is devoted to figuring out the fashion of singer/songwriter Taylor Swift and can host a set of exact finds from her wardrobe. Here are some the reason why you should think about using a Clothing Brand Name Generator to search out clothing shop name concepts for your business. Namify’s Clothing Brand Name Generator also provides a free logo with each registered name. 100s of subtle emblem ideas matching your bought area name that can assist you build a memorable model.
Unfortunately, it is currently out of inventory on the Zara web site, but you could possibly discover one in-store. YSL's well-loved perfume Libre, £92, is loaded with contemporary orange blossom from Morocco and fragrant calm lavender from France, providing a memorable an expensive-feeling floral and musky olfactory experience. For a fraction of the worth, Zara's Golden Decade, £22.99, also options addictive notes of jasmine, orange blossom, mandarin and lavender, without knocking your wallet.

HGDI analysis of 15 loci MIRU demonstrated that eight out of 15 loci were highly discriminant. Of note, all pre-XDR strains belongs to many clades, meaning that there no association between gyrA mutants and particular clade. Overall, the data generated by this study (i) describe the population structure of MDR MTBC in Morocco which is highly homogenous, (ii) confirm that TB in Morocco is almost exclusively transmitted by modern and evolutionary lineages with high level of biodiversity seen by MIRU, and (iii) validate the use of optimized 15-loci MIRU-VNTR format for future investigations in Morocco.The relentless role of invasive species in the extinction of native biota requires predictions of ecosystem vulnerability to inform proactive management strategies. The worldwide invasion and range expansion of predatory northern pike (Esox lucius) has been linked to the decline of native fishes and tools are needed to predict the vulnerability of habitats to invasion over broad geographic scales. To address this need, we coupled an intrinsic potential habitat modelling approach with a Bayesian network to evaluate the vulnerability of five culturally and economically vital species of Pacific salmon (Oncorhynchus spp.) to invasion by northern pike. This study was conducted along 22,875 stream km in the Southcentral region of Alaska, USA. Pink salmon (O. gorbuscha) were the most vulnerable species, with 15.2% (2,458 km) of their calculated extent identified as "highly" vulnerable, followed closely by chum salmon (O. keta, 14.8%; 2,557 km) and coho salmon (O. kisutch, 14.7%; 2,536 km). Moreover, all five Pacific salmon species were highly vulnerable in 1,001 stream km of shared habitat. This simple to implement, adaptable, and cost-effective framework will allow prioritizing habitats for early detection and monitoring of invading northern pike.Filoviruses (Family Filoviridae genera Ebolavirus and Marburgvirus) are negative-stranded RNA viruses that cause severe health effects in humans and non-human primates, including death. Except in outbreak settings, vaccines and other medical countermeasures against Ebola virus (EBOV) will require testing under the FDA Animal Rule. Multiple vaccine candidates have been evaluated using cynomolgus monkeys (CM) exposed to EBOV Kikwit strain. To the best of our knowledge, however, animal model development data supporting the use of CM in vaccine research have not been submitted to the FDA. This study describes a large CM database (122 CM, 62 female and 60 male, age 2 to 9 years) and demonstrates the consistency of the CM model through time to death models and descriptive statistics. CMs were exposed to EBOV doses of 0.1 to 100,000 PFU in 33 studies conducted at three Animal Biosafety Level 4 facilities, by three exposure routes. Time to death was modeled using Cox proportional hazards models with a frailty term that incorporated study-to-study variability. Despite significant differences attributed to exposure variables, all CMs exposed to the 100 to 1,000 pfu doses commonly used in vaccine studies died or met euthanasia criteria within 21 days of exposure, median 7 days, 93% between 5 and 12 days of exposure. Moderate clinical signs were observed 4 to 5 days after exposure and preceded death or euthanasia by approximately one day. Viremia was detected within a few days of infection. Hematology indices were indicative of viremia and the propensity for hemorrhage with progression of Ebola viremia. Changes associated with coagulation parameters and platelets were consistent with coagulation disruption. Changes in leukocyte profiles were indicative of an acute inflammatory response. Increased liver enzymes were observed shortly after exposure. Taken together, these factors suggest that the cynomolgus monkey is a reliable animal model for human disease.Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the second leading cause of cancer-related deaths in the world. https://www.selleckchem.com/products/R7935788-Fostamatinib.html It has been the most prevalent malignancy in Taiwan for consecutive thirteen years. Despite the diversity of its etiologic and pathophysiologic factors, a biological process named as epithelial-mesenchymal transition (EMT) is indispensable in the progression of epithelial cancer. Our aim is to investigate the correlation between the expression of 8 EMT-related proteins (E-cadherin, β-catenin, claudin-1, CD44, N-cadherin, fibronectin, vimentin, S100A4) and the clinicopathologic features of CRC in Taiwan, along with the DNA CpG epigenetic status of CD44 gene. In immunohistochemical assessment, decreased expression of E-cadherin is statistically associated with the progression of cancer stage, while decreased expression of claudin-1 as well as increased β-catenin nuclear translocation and N-cadherin expression is statistically associated with the progression of histopathologn level of CD44 gene and its protein expression, however, show no correlation with the clinicopathologic features in CRC.SARS-CoV-2 pandemic is causing high morbidity and mortality burden worldwide with unprecedented strain on health care systems. To investigate the time course of the antibody response in relation to the outcome we performed a study in hospitalized COVID-19 patients. As comparison we also investigated the time course of the antibody response in SARS-CoV-2 asymptomatic subjects. Study results show that patients produce a strong antibody response to SARS-CoV-2 with high correlation between different viral antigens (spike protein and nucleoprotein) and among antibody classes (IgA, IgG, and IgM and neutralizing antibodies). The antibody peak is reached by 3 weeks from hospital admission followed by a sharp decrease. No difference was observed in any parameter of the antibody classes, including neutralizing antibodies, between subjects who recovered or with fatal outcome. Only few asymptomatic subjects developed antibodies at detectable levels.Prevalence of toxigenic Vibrio cholerae O1 in aquatic reservoirs in Bangladesh apparently increases coinciding with the occurrence of seasonal cholera epidemics. In between epidemics, these bacteria persist in water mostly as dormant cells, known as viable but non-culturable cells (VBNC), or conditionally viable environmental cells (CVEC), that fail to grow in routine culture. CVEC resuscitate to active cells when enriched in culture medium supplemented with quorum sensing autoinducers CAI-1 or AI-2 which are signal molecules that regulate gene expression dependent on cell density. V. cholerae O1 mutant strains with inactivated cqsS gene encoding the CAI-1 receptor has been shown to overproduce AI-2 that enhance CVEC resuscitation in water samples. Since V. cholerae non-O1 non-O139 (non-cholera-vibrios) are abundant in aquatic ecosystems, we identified and characterized naturally occurring variant strains of V. cholerae non-O1 non-O139 which overproduce AI-2, and monitored their co-occurrence with V. cholerae O1 in water samples.

BMS is significantly associated with psychological symptoms. This condition requires proper treatment and support because it can represent psychological or mental issues and/or have a significant effect on daily life.
BMS is significantly associated with psychological symptoms. This condition requires proper treatment and support because it can represent psychological or mental issues and/or have a significant effect on daily life.
Inflammation is one of the key mechanisms involved in functional impairment after stroke. Intercellular adhesion molecule-1 (ICAM-1) is an important inflammatory molecule in the body. The purpose of our study was to determine the correlation between ICAM-1 and the prognosis of acute ischemic stroke (AIS).

286 AIS patients treated at Beijing Tiantan Hospital were continuously included in the study. The demographic data of the patients were collected, and the fasting blood within 24 hours of admission was collected to detect the clinical indicators. The functional prognosis was measured using the modified Rankin Scale (mRS) 3 months after stroke. The poor prognosis is defined as mRS ≥ 3. The enzyme-linked immunosorbent assay (ELISA) was used to determine the serum ICAM-1 levels.

The serum ICAM-1 levels of patients with poor prognosis were significantly higher than that of patients with good prognosis (144.2 ± 14.8 vs 117.5 ± 12.1 pg/ml). Receiver operating characteristic curve (ROC) analysis showed that the sensitivity and specificity of serum ICAM-1 for predicting the prognosis of AIS were 74% and 76%, respectively. In logistic regression analysis, the serum ICAM-1 level is still an independent predictor of poor prognosis (odds ratio [OR] 0.52; 95% confidence interval [CI] 0.318-0.839).

Higher serum ICAM-1 levels on admission in AIS patients might increase the risk of poor prognosis.
Higher serum ICAM-1 levels on admission in AIS patients might increase the risk of poor prognosis.
Recently, immunotherapy and microRNA have shown much more promises in oncology research, inspiring new hope for a cure for various malignancies. Specifically, the function and mechanisms of action of pembrolizumab have been investigated in many cancers, but not in laryngeal squamous cell carcinoma. The present study thus focused on the effect of hsa-miR-128a on pembrolizumab in laryngeal cancer cells as well as tried to elucidate the mechanisms that may mediate this effect.

Hep2 and AMC-HN8 cell lines were utilized to create stable cell lines that overexpressing hsa-miR-128a. Using the immunotherapy assay, the contribution of hsa-miR-128a to pembrolizumab sensitivity was evaluated. By performing the dual luciferase assay and quantitative real-time polymerase chain reaction, the possible mechanisms of hsa-miR-128a were identified.

Hsa-miR-128a was overexpressed in laryngeal cancer cell lines successfully. The immunotherapy assay revealed that upregulating hsa-miR-128a augmented the effect of pembrolizumab. Moreover, hsa-miR-128a targeted BMI-1 and might played a role in the p53 pathway.

Hsa-miR-128a boosted the effect of pembrolizumab on laryngeal cancer cells, perhaps via the p53 pathway. Therefore, hsa-miR-128a might be a novel target in laryngeal cancer treatment.
Hsa-miR-128a boosted the effect of pembrolizumab on laryngeal cancer cells, perhaps via the p53 pathway. Therefore, hsa-miR-128a might be a novel target in laryngeal cancer treatment.
Nonsmall cell lung cancer (NSCLC) is the most common type of lung cancer, and the majority of NSCLC patients are diagnosed at the advanced stage. https://www.selleckchem.com/products/Rapamycin.html Chemotherapy is still the main treatment at present, and the overall prognosis is poor. In recent years, immunotherapy has developed rapidly. Immune checkpoint inhibitors (ICIs) as the representative have been extensively applied for treating various types of cancers. Tumor mutation burden (TMB) as a potential biomarker is used to screen appropriate patients for treatment of ICIs. To verify the predictive efficacy of TMB, a systematic review and meta-analysis were conducted to explore the association between TMB and ICIs.

PubMed, EMBASE, Cochrane Library, and son on were systematically searched from inception to April 2020. Objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were estimated.

A total of 11 studies consisting of 1525 nonsmall cell lung cancer (NSCLC) patients were included. Comparison of high and low TMB pooled HRs for OS, 0.57 (95% CI 0.32 to 0.99;
= 0.046); PFS, 0.48 (95% CI 0.33 to 0.69;
< 0.001); ORR, 3.15 (95% CI 2.29 to 4.33;
< 0.001). Subgroup analysis values pooled HRs for OS, 0.75 (95% CI 0.29 to 1.92,
= 0.548) for blood TMB (bTMB), 0.44 (95% CI 0.26 to 0.75,
= 0.003) for tissue TMB (tTMB); for PFS, 0.54 (95% CI 0.29 to 0.98,
= 0.044) and 0.43 (95% CI 0.26 to 0.71,
= 0.001), respectively.

These findings imply that NSCLC patients with high TMB possess significant clinical benefits from ICIs compared to those with low TMB. As opposed to bTMB, tTMB was thought more appropriate for stratifying NSCLC patients for ICI treatment.
These findings imply that NSCLC patients with high TMB possess significant clinical benefits from ICIs compared to those with low TMB. As opposed to bTMB, tTMB was thought more appropriate for stratifying NSCLC patients for ICI treatment.This research is aimed at determining the physicochemical properties (resin, wax, balsams, pH, moisture, ash, and mineral contents) of propolis samples collected from different geographical areas in Morocco, as well as evaluating the antioxidant and antibacterial activities of these samples. The results showed the following values for physicochemical analysis resin (17.42-58.01%), wax (21.31-70.12%), balsam (0.27-2.12%), pH (3.7-5.3), moisture (1.02-3.65%), and ash (0.72-5.01%). The phenolic and flavone/flavonol contents of samples were ranged between 6.74 mg FAE/g and 149.13 mg FAE/g and between 1.19 mg QE/g and 108.11 mg QE/g, respectively. The sample P3 presented also the strongest radical scavenging activity toward DPPH, ABTS free radicals, and FRAP assay with IC50 values of 0.021, 0.026, and 0.042 mg/mL, respectively. All propolis samples showed significant inhibitory effects against all tested microorganisms with MICs ranging from 0.28 mg/mL to 1.12 mg/mL for Gram-negative strains and from 0.002 mg/mL to 1.12 mg/mL for Gram-positive strains. A strong correlation was found between resin, total phenolic compounds, flavones/flavonols, and antioxidant activity. Linear discriminant analysis revealed that the samples studied were divided into two groups which were differentiated by the data of antioxidant activity, mineral contents, and antibacterial activity. It can be concluded that the physicochemical properties, mineral content, and biological activities of Moroccan propolis depend on their geographical and botanical origin.
Sexual and reproductive health (SRH) communication is most likely to promote healthy sexual practices and to reduce risky sexual behavior among adolescents. Communication is the principal means for parents to transmit sexual values and knowledge to their children. Although there are few studies conducted on parent-adolescent communication, there is no study conducted in the town of Ambo. This study was aimed at assessing the level of parent-adolescent communication on SRH issues and its associated factors among school students in Ambo town, Oromia, Ethiopia.

An institution-based concurrent mixed-method cross-sectional study was conducted among 591 secondary and preparatory school students in Ambo town from February 24
to March 9
, 2019. A systematic sampling technique was used to select the study subject. Data were collected through self-administered questionnaires, and FGD was conducted with parents of students. Data was entered using EpiData version 3.1 and exported to SPSS version 23.0 for statisticmportance of sex education, source of information about SRH issues (school and media), and mother's openness to communicate about SRH issues were identified to be factors associated with the communication. Therefore, the concerned body should consider the identified factors to improve the current level of parent-adolescent communication and adolescent reproductive health.
The study showed that parent-adolescent communication on SRH issues is low. Being female, those from a private school, father's education, perceived importance of sex education, source of information about SRH issues (school and media), and mother's openness to communicate about SRH issues were identified to be factors associated with the communication. Therefore, the concerned body should consider the identified factors to improve the current level of parent-adolescent communication and adolescent reproductive health.Previous studies identify owner-related issues, such as cost and housing, as common reasons for relinquishment of companion animals to animal shelters. It is likely that the burden of surrendering for owner-related reasons falls on those who are socially vulnerable (e.g., low income, unemployed); however, very few studies have assessed social determinants as a predictor of animal relinquishment. The present study used the Canadian Index of Multiple Deprivation (CIMD), which uses four factors of social vulnerability (Ethnocultural Composition, Economic Dependency, Residential Instability, and Situational Vulnerability) to predict risk of surrender for various reasons, of various species and breeds, and of various health statuses across British Columbia, Canada (n = 29,236). We found that CIMD factors predicted increased risk of surrender across many shelter variables. For further understanding of differences between areas in the province, the present study also analyzed the relationship between CIMD factors an further interventions in marginalized populations to increase retention of animals.The deposition of Schistosoma japonicum (S. japonicum) eggs commonly induces inflammation, fibrosis, hyperplasia, ulceration, and polyposis in the colon, which poses a serious threat to human health. However, the underlying mechanism is largely neglected. Recently, the disorder of glucose and lipid metabolism was reported to participate in the liver fibrosis induced by the parasite, which provides a novel clue for studying the underlying mechanism of the intestinal pathology of the disease. This study focused on the metabolic reprogramming profiles of glucose and lipid in the colon of mice infected by S. japonicum. We found that S. japonicum infection shortened the colonic length, impaired intestinal integrity, induced egg-granuloma formation, and increased colonic inflammation. The expression of key enzymes involved in the pathways regulating glucose and lipid metabolism was upregulated in the colon of infected mice. Conversely, phosphatase and tensin homolog deleted on chromosome ten (PTEN) and its downstream signaling targets were significantly inhibited after infection. In line with these results, in vitro stimulation with soluble egg antigens (SEA) downregulated the expression of PTEN in CT-26 cells and induced metabolic alterations similar to that observed under in vivo results. Moreover, PTEN over-expression prevented the reprogramming of glucose and lipid metabolism induced by SEA in CT-26 cells. Overall, the present study showed that S. japonicum infection induces the reprogramming of glucose and lipid metabolism in the colon of mice, and PTEN may play a vital role in mediating this metabolic reprogramming. These findings provide a novel insight into the pathogenicity of S. japonicum in hosts.

The experiments were performed to classify BUIs between (i) normal and benign, (ii) normal and malignant, and (iii) benign and malignant cases. The results show that classification accuracy of > 94%, precision of > 92%, sensitivity of > 92% and specificity of > 90% are achieved applying the developed new schemes or framework.

In this work, a machine-learning scheme is employed to detect/classify the disease using BUI and achieves promising results. In future, we will test the feasibility of implementing deep-learning method to this framework to further improve detection accuracy.
In this work, a machine-learning scheme is employed to detect/classify the disease using BUI and achieves promising results. In future, we will test the feasibility of implementing deep-learning method to this framework to further improve detection accuracy.
As millions of teachers have been forced to rely upon remote teaching due to the closure of schools during the COVID-19 pandemic. It is particularly important to understand the extent to which teacher's psychological wellbeing has been affected by this global health crisis.

The aim of this comprehensive systematic review and meta-analysis was twofold 1) ascertain the prevalence of stress, anxiety, depression among teachers during the COVID-19 outbreak; 2) identify the associated factors of these psychological wellbeing domains of the teachers.

Academic Search Premier, Eric, PsycInfo, Scopus, and Web of Science were searched for articles published from December 2019 and July 2021, using search terms including "COVID-19" "anxiety" "depression" "stress", and "teachers".

This study included 54 studies synthesising data from 256,896 teachers across 22 countries. The meta-analysis showed higher prevalence of stress (62.6%, 95% Confidence Interval [CI] 46.1-76.6), compared to anxiety (36.3%, 95% CI 28.5-44.9) and depression (59.9%, 95% CI 43.4-74.4) among teachers. Teachers' experiences of these psychological issues were associated with various socio-demographic and institutional factors, including gender, nature of online teaching, job satisfaction, teaching experience, and the volume of workload. Additionally, several protective factors, such as regular exercises and provision of technical support for online teaching, reduced teachers' negative psychological experiences.

There is a need for authorities to formulate educational policies to improve teachers' wellbeing at the time of global crisis. Special attention should be paid to assist female teachers in overcoming physical and mental stressors.
There is a need for authorities to formulate educational policies to improve teachers' wellbeing at the time of global crisis. Special attention should be paid to assist female teachers in overcoming physical and mental stressors.
Across the global landscape, mental health care still exhibits challenges because of the lack of human and professional resources to face its consequences. In Morocco, mental health problems affect mainly adolescents and young adults, with a clear impact on functional engagement in their daily lives. Occupational therapy, as a holistic and person-centered practice, may be an ideal mental health strategy to promote health and well-being through occupation, thereby enabling individuals to participate in regular daily activities.

To understand, from an intercultural perspective, the point of view of mental health professionals regarding the role and importance of occupation-based practices in Errazi Mental Health Hospital in Salé(Rabat) Morocco.

A qualitative research design was used for this study. Data collection consisted of semi-structured interviews with 12 mental health care professionals (non-occupational therapists). These results were used to gain an understanding of their perspectives regarding tultural perspective of mental health, and the sociocultural meaning rooted in occupations, but also the relevance of incorporating a community-centered approach. Moreover, it discusses how occupational therapy education in Morocco must incorporate an intercultural perspective of the therapy's theory and practice.
Call center workers are highly susceptible to work-related musculoskeletal disorders (WRMSDs) as well as mental stress. Nonetheless, there has been a surprising paucity in the body of the research regarding interventions among call center workers.

The purpose of this paper is to investigate the effectiveness of a multicomponent ergonomic intervention program on mental workload, mental fatigue and WRMSDs of call center employees.

A non-randomized interventional study with a single group pretest-posttest design was conducted among 84 call center workers of a private telecommunication company in the city of Tehran, Iran. At the baseline, data regarding WRMSDs prevalence, mental workload and mental fatigue were collected by means of standard Nordic, NASA-TLX and SOFI questionnaires, respectively. Then, subjects participated in a multifaceted intervention program including comprehensive office ergonomic training, work layout improvement, supervised on-site face to face visits, and provision of quality break aspects of the work as well. The future studies should consider investigating such outcomes.
Although the primary focus of many ergonomic interventions has remained to measure physical outcomes of the work place, our findings show that multicomponent interventions are indeed capable of boosting cognitive aspects of the work as well. The future studies should consider investigating such outcomes.
The Oswestry Disability Index (ODI) is a common outcome-measure used for assessment of spinal disorders with three officially updated versions. https://www.selleckchem.com/products/au-15330.html However, there are recently published articles that still use ODI-1.0. This suggests the existence of a block on information flow between developers and end-users.

To investigate the articles with missing citation to the latest ODI version, to calculate the life span of previous ODI version and to investigate the existence of a block on information flow.

PMC-PubMed citation dataset is analyzed by CNA and text processing methods.

The most important finding of this study is that there is no block on information flow between developers and users in terms of visibility in citations and full text access restrictions. Three different sub-networks are identified between ODI-1.0 and ODI-2.0 articles. 14% (165) of articles have citation to ODI-1.0 and ODI-2.0 version-articles. The time limit that is required for the new ODI version to become dominant in the literature is between 4 and 9 years.

There is a missing citation problem in the ODI literature which is not a result of a block on information flow between developers and end-users.
There is a missing citation problem in the ODI literature which is not a result of a block on information flow between developers and end-users.
The aging of the workforce is changing, but working conditions have not changed at the same exponential growth rate for senior workers. Such a situation can compromise the worker's physical and cognitive capability, reducing the ability to perform work activities.

This study aims to understand the main functional capacity changes in senior workers in the automotive industry and to determine the contribution of working conditions on the decline of the functional capacity in senior workers.

To achieve the objectives of the study, a set of questionnaires (Sociodemographic Data, COPSOQ, Nordic Questionnaire, and Par-Q) and a battery of 4 functional capacity tests were used.

Work conditions, namely awkward postures, force demands and manual material handling, and age, were statistically associated to the functional decline in workers. Additionally, multiple linear regression showed that height, weight, seniority, and strength have predictive value to the handgrip decline (both positions HG2 and HG5).

These results suggest that workers' handgrip assessment should be considered as a future measure as an indicator of strength ability in the occupational field.
These results suggest that workers' handgrip assessment should be considered as a future measure as an indicator of strength ability in the occupational field.
The number of workers who have previously undergone a cancer treatment is increasing, and possible late treatment effects (fatigue, physical and cognitive complaints) may affect work ability.

The aim of the study was to investigate the impact of late treatment effects and of job resources (autonomy, supportive leadership style, and colleagues' social support) on the future work ability of employees living 2-10 years beyond a breast cancer diagnosis.

Data at T1 (baseline questionnaire) and at T2 (9 months later) were collected in 2018 and 2019 (N = 287) among Dutch-speaking workers with a breast cancer diagnosis 2-10 years ago. Longitudinal regression analyses, controlling for years since diagnosis, living with cancer (recurrence or metastasis), other chronic or severe diseases, and work ability at baseline were executed.

Higher levels of fatigue and cognitive complaints at baseline predicted lower future work ability. The three job resources did not predict higher future work ability, but did relate cross-sectionally with higher work ability at baseline. Autonomy negatively moderated the association between physical complaints and future work ability.

Fatigue and cognitive complaints among employees 2-10 years past breast cancer diagnosis need awareness and interventions to prevent lower future work ability. Among participants with average or high levels of physical complaints, there was no difference in future work ability between medium and high autonomy. However, future work ability was remarkably lower when autonomy was low.
Fatigue and cognitive complaints among employees 2-10 years past breast cancer diagnosis need awareness and interventions to prevent lower future work ability. Among participants with average or high levels of physical complaints, there was no difference in future work ability between medium and high autonomy. However, future work ability was remarkably lower when autonomy was low.
The coronavirus (COVID-19) pandemic brought about restrictions, additional workload, insecurity, or need for inventing new routines for professionals worldwide. The pandemic and its restrictions have been discussed as a career shock.

Adding knowledge to this, our study investigated the academic and family (care) situation of young scientists in a German technical university.

We conducted an online survey including young scientists from a technical university in Germany in April 2021. 346 participants (mean age 33 years, 37% women) gave self-ratings on academic and life situation during the pandemic year, care work, preferences for scientific career and family life.

Family and career were independent priorities (r = 0.021, p = 0.676). Two thirds (68%) of the young scientists reported no deterioration in scientific outcome during the pandefmic year. But, care times and number of children impacted negatively on scientific productivity in terms of publications. This was true for both women and men.

Young scientists need individual support for their career perspective, according to their concrete career level and life situation.
Young scientists need individual support for their career perspective, according to their concrete career level and life situation.