The purpose of this study was to investigate the prevalence, nature, and management of post-surgical emergency after-hours calls in a dental school setting with predoctoral students, graduate students/residents, and faculty providers.
A patient chart review (March 2018-February 2020) for post-surgical calls through the emergency after-hours pager system was conducted at the Marquette University School of Dentistry. The total number of surgical procedures, procedure type, the timing of call, operator experience, concern, and recommendation given during the call were documented.
During the review period, 83 calls (from 75 patients) were recorded after 8,487 surgical procedures (1% of procedures). Patients called 5.4 ± 0.8 days postoperatively. Procedure type affected call prevalence (p=0.04), with most calls made after extractions (69.9% of all calls; 1% of extractions; 58/5,725), implant placement (6%; 0.9% of implant placements; 5/530) and periodontal plastic surgery (6%; 3.1% of all plastic surgeries; anagement of after-hours emergencies and may reduce self-referrals to the hospital ED.This case study reports the advantages of micro-CT to aid the investigative process in a complex dismemberment case. Micro-CT was successfully implemented to scan all skeletal remains of a dismembered female. The digital models were utilized to (i) screen for any further injuries not related to the dismemberment, (ii) provide measurements from false starts non-destructively, and (iii) visually represent the evidence in a structured format in court to improve the understanding of the forensic evidence by the jury. Acquiring high-resolution scans in this manner improved the efficiency of the forensic investigation by screening the remains and provided complementary toolmark evidence to the investigating team and forensic pathologist. A total of 14 false starts were identified along with the directionality of each dismemberment cut. Furthermore, the visual 3D representation of the remains in court provided a powerful tool to communicate this important evidence to the jury and form a prosecution narrative. As a forensic radiological method, micro-CT provided valuable information both in the investigation and the court presentation.Sea buckthorn (Hippophae rhamnoides), a horticulturally multipurpose species in the family Elaeagnaceae, can build associations with Frankia actinomycetes to enable symbiotic nitrogen-fixing. Currently, no high-quality reference genome is available for an actinorhizal plant, which greatly hinders the study of actinorhizal symbiotic nodulation. Here, by combining short-read, long-read and Hi-C sequencing technologies, we generated a chromosome-level reference genome of H. rhamnoides (scaffold N50 65 Mb, and genome size 730 Mb) and predicted 30 812 protein-coding genes mainly on 12 pseudochromosomes. Hippophae rhamnoides was found to share a high proportion of symbiotic nodulation genes with Medicago truncatula, implying a shared molecular mechanism between actinorhizal and rhizobial symbioses. Phylogenetic analysis clustered the three paralogous NODULE INCEPTION (NIN) genes of H. rhamnoides with those of other nodulating species, forming the NIN group that most likely evolved from the ancestral NLP group. The genome of H. rhamnoides will help us to decipher the underlying genetic programming of actinorhizal symbiosis, and our high-quality genome and transcriptomic resources will make H. rhamnoides a new excellent model plant for actinorhizal symbiosis research.
Ventriculostomy-related infection (VRI) is a common complication in patients with traumatic brain injury (TBI) treated with an external ventricular drain (EVD). The aim of this study was to investigate incidence and characteristics of patients with VRI, and to explore diagnostic criteria to confidently rule out VRI in patients with TBI.
This retrospective cohort pilot study included adults with severe TBI who were admitted to the ICU and received an EVD, during a 26-month period. Patients were categorized as having Culture-positive VRI, Culture-negative VRI, or No VRI. Variables that were potentially associated with Culture-positive VRI was analyzed, and predictive values were calculated.
75 of 215 patients with severe TBI (35%) underwent EVD placement; nine of these (12%) were classified as Culture-negative VRI and eight (11%) as Culture-positive VRI. The CSF cell counts that led to VRI treatment were compared with 46 CSF cell counts from No VRI patients. A CSF/plasma glucose ratio below 0.6had a negative predictive value (NPV) for culture-verified VRI of 0.97 (95% CI 0.85-1), whereas a combination of three CSF-derived biomarkers within the reference limits (white/red blood cell ratio, CSF/plasma glucose ratio, and protein content) ruled out Culture-positive VRI in this cohort (PPV 0, 95% CI 0-0.14). C-reactive protein did not reliably predict VRI.
In this pilot study of patients after severe, a combination of biomarkers within reference limits ruled out VRI (PPV 0, CI 0-0.14). Hypoglycorrhachia was a sensitive marker of VRI (NPV 0.97, CI 0.85-1). Systemic signs and markers of infection did not predict VRI.
In this pilot study of patients after severe, a combination of biomarkers within reference limits ruled out VRI (PPV 0, CI 0-0.14). Hypoglycorrhachia was a sensitive marker of VRI (NPV 0.97, CI 0.85-1). Systemic signs and markers of infection did not predict VRI.Climate change is increasing global temperatures and the frequency and severity of droughts in many regions. These anthropogenic stresses pose a significant threat to plant performance and crop production. The plant-associated microbiome modulates the impacts of biotic and abiotic stresses on plant fitness. However, climate change-induced alteration in composition and activities of plant microbiomes can affect host functions. Here, we highlight recent advancements in our understanding of the impact of climate change (warming and drought) on plant-microbiome interactions and on their ecological functions from genome to ecosystem scales. We identify knowledge gaps, propose new concepts and make recommendations for future research directions. It is proposed that in the short term (years to decades), the adaptation of plants to climate change is mainly driven by the plant microbiome, whereas in the long term (century to millennia), the adaptation of plants will be driven equally by eco-evolutionary interactions between the plant microbiome and its host. A better understanding of the response of the plant and its microbiome interactions to climate change and the ways in which microbiomes can mitigate the negative impacts will better inform predictions of climate change impacts on primary productivity and aid in developing management and policy tools to improve the resilience of plant systems.
Intellectual disability is a form of neurodevelopmental disorders that begin in childhood and is characterized by substantial intellectual difficulties as well as difficulties in conceptual, social, and practical areas of living. Several genetic and nongenetic factors contribute to its development; however, its most severe forms are generally attributed to single-gene defects. High-throughput technologies and data sharing contributed to the diagnosis of hundreds of single-gene intellectual disability subtypes.
We applied exome sequencing to identify potential variants causing syndromic intellectual disability in six Sudanese patients from four unrelated families. Data sharing through the Varsome portal corroborated the diagnosis of one of these patients and a Tunisian patient investigated through exome sequencing. Sanger sequencing validated the identified variants and their segregation with the phenotypes in the five studied families.
We identified three pathogenic/likely pathogenic variants in CCDC82, ADAT3, and HUWE1 and variants of uncertain significance in HERC2 and ATP2B3. The patients with the CCDC82 variants had microcephaly and spasticity, two signs absent in the two previously reported families with CCDC82-related intellectual disability.
In conclusion, we report new patients with pathogenic mutations in the genes CCDC82, ADAT3, and HUWE1. We also highlight the possibility of extending the CCDC82-linked phenotype to include spastic paraplegia and microcephaly.
In conclusion, we report new patients with pathogenic mutations in the genes CCDC82, ADAT3, and HUWE1. We also highlight the possibility of extending the CCDC82-linked phenotype to include spastic paraplegia and microcephaly.The threat of COVID-19 has triggered nationalism, prejudice and support for anti-democratic political systems around the world. Authoritarianism-an individual's orientation toward social conformity and individual autonomy-shapes interpretations of and responses to threat. We drew on theories of authoritarianism and threat to propose that authoritarians and libertarians will interpret the threat of COVID-19 in distinct ways. An online survey of 368 Scottish nationals was administered via the Prolific platform. Original measures of realistic and symbolic threat from COVID-19 were included, along with an established measure of the authoritarian predisposition. Linear regression analyses showed that COVID-19 was perceived primarily as a realistic threat to physical and material well-being; however, authoritarians were more likely than others to interpret the novel coronavirus as a symbolic threat to their prevailing values. Our findings contribute to understanding the psychology of pandemic-era attitudes and behaviours and provide insight into possible political consequences of the coronavirus threat. https://www.selleckchem.com/products/gsk864.html The results also demonstrate how considering authoritarians' subjective construal of threats can resolve questions in the authoritarianism and threat literature and advance theory.Refugees typically experience stronger migration forcedness and higher migration-related perils (harm, adversities and hardship) than do non-refugee migrants. We explored how refugees' and non-refugee migrants' perceptions of their own forcedness of migration and related perils before and during migration are associated with regret about leaving their country of origin and their confidence in integration. In two studies conducted with refugee and non-refugee migrants in Germany (total N = 336), we found correlations between perceived forcedness and premigration perils, and perils during migration, with meaningful differences between groups from different countries. Importantly, regret about migration was predicted by an interaction effect of perceived forcedness and migration perils Perils encountered during migration increased regret about having migrated when perceived forcedness was low (vs. high). As important potential predictors of confidence in integration and regret, we also assessed discrimination experienced in the receiving society (Study 1) and resilience (Study 2). Importantly, we found that high (vs. low) perceived migration perils buffered negative effects of discrimination experienced in the host country. We discuss implications of our findings for integration in the receiving society, highlighting the role of perceived forcedness in coping with distressing experiences before and after arrival in the host country.
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