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22 hrs ago


Nowadays, novel less-expensive nanoformulations for in situ-controlled and safe delivery of photosensitisers (PSs) against opportunistic pathogens in body-infections areas need to be developed. Antimicrobial photodynamic therapy (aPDT) is a promising approach to treat bacterial infections that are recalcitrant to antibiotics. In this paper, we propose the design and characterization of a novel nanophototherapeutic based on the trade cyclodextrin CAPTISOL® (sulfobutylether-beta-cyclodextrin, SBE-βCD) and 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphine tetrakis(p-toluenesulfonate) (TMPyP) to fabricate efficient biocompatible systems for aPDT. Spherical nanoassemblies of about 360 nm based on CAPTISOL®/TMPyP supramolecular complexes with 11 stoichiometry and apparent equilibrium binding constant (Kb ≅ 1.32 × 105 M-1) were prepared with entrapment efficiency of ≅ 100% by simple mixing in aqueous media and freeze-drying. These systems have been characterized by complementary spectroscopy and microscopy technility thus optimizing the PDT effect at the site of action. These results can open routes for in vivo translational studies on nano(photo)drugs and nanotheranostics based on less expensive formulations of CD and PS.Transient local over-dry environment might be a contributor and an explanation for the observed asynchronous local rises in Covid-19 mortality. We propose that a habitat's air humidity negatively correlate with Covid-19 morbidity and mortality, and support this hypothesis on the example of publicly available data from German federal states.SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19. DEC has inhibitory effects on arachidonic acid metabolism to prostaglandins, little known anti-viral effects on animal retroviruses and demonstrated anti-inflammatory actions in animal models of lung inflammation indicating the need to explore this hypothesis further. We believe this is the first time DEC is being proposed to treat COVID-19.The discovery of the 2,000-year-old Dead Sea Scrolls had an incomparable impact on the historical understanding of Judaism and Christianity. "Piecing together" scroll fragments is like solving jigsaw puzzles with an unknown number of missing parts. We used the fact that most scrolls are made from animal skins to "fingerprint" pieces based on DNA sequences. Genetic sorting of the scrolls illuminates their textual relationship and historical significance. Disambiguating the contested relationship between Jeremiah fragments supplies evidence that some scrolls were brought to the Qumran caves from elsewhere; significantly, they demonstrate that divergent versions of Jeremiah circulated in parallel throughout Israel (ancient Judea). Similarly, patterns discovered in non-biblical scrolls, particularly the Songs of the Sabbath Sacrifice, suggest that the Qumran scrolls represent the broader cultural milieu of the period. Finally, genetic analysis divorces debated fragments from the Qumran scrolls. Our study demonstrates that interdisciplinary approaches enrich the scholar's toolkit.Mycolic acid methyl esters were extracted from Mycobacterium avium by a mild saponification protocol, designed to preserve labile components. The resulting mixture of α-, keto- and wax ester mycolates was accompanied by some degraded ω-carboxymycolic acid dimethyl esters, whose overall structures were found to support previous studies. Chromatography of the mono-carboxylic mycolates gave an inseparable mixture of keto- and wax ester mycolates and separate α-mycolates. Reduction of the ketomycolate components allowed isolation and characterisation of intact wax ester mycolates for the first time. Minor α- and ω-carboxymycolates were detected in which methyl branches were located on either the proximal or distal sides of trans-alkene groups.Background Brown tumors are giant cell-rich lesions that result from abnormal bone metabolism in hyperparathyroidism, one of the most common endocrine disorders worldwide. Brown tumors occasionally affect the jaws and, despite well-known clinical and microscopic features, their molecular pathogenesis remains unclear. We investigated the presence of pathogenic activating mutations in TRPV4, FGFR1, and KRAS in a cohort of brown tumors since these have recently been reported in giant-cell lesions of the jaws and non-ossifying fibromas of the bones (FGFR1 and KRAS), which are histologic mimics of brown tumors. Methods We target sequenced 13 brown tumors of the jaws associated with primary or secondary hyperparathyroidism. As mutations in these genes are known to activate the MAPK/ERK signaling pathway, we also assessed the immunostaining of the phosphorylated form of ERK1/2 (pERK1/2) in these lesions. Results KRAS pathogenic mutations were detected in seven cases (p.G12V n = 4, p.G12D n = 1, p.G13D n = 1, p.A146T n = 1). KRAS variants of unknown significance (VUS), p.A134T and p.E37K, were also detected. All samples showed wild-type sequences for FGFR1 and TRPV4 genes. The activation of the MAPK/ERK signaling pathway was demonstrated by pERK1/2 immunohistochemical positivity of the brown tumors´ mononuclear cells. Conclusion Mutations in KRAS and activation of the MAPK/ERK signaling pathway were detected in brown tumors of hyperparathyroidism of the jaws, expanding the spectrum of giant cell lesions whose molecular pathogenesis involve RAS signaling.In the era of a pandemic, networking opportunities have evaporated, and researchers are reinventing ways to connect with the community. It is our pleasure to build some of those connections, especially for young authors, by introducing you to eleven scientists whose work is featured in this issue. https://www.selleckchem.com/products/rin1.html Here, they share their diverse and splendid journeys-from early concepts to the fruition of published work.Background Preterm infants are at risk for impaired neurodevelopment. Inflammation may be an important modifiable mediator of preterm birth and neurodevelopmental impairment, but few studies have examined longitudinal measures of inflammation. Objective To determine the relationship between longitudinal measures of inflammation and neurobehavior in very preterm infants. Study design Non-experimental, repeated measures cohort study. Methods Very preterm infants were enrolled between October 2017 and December 2018. Blood was collected weekly until 35 weeks post-menstrual age for the quantification of plasma cytokines. Neurobehavior was assessed at 35 weeks post-menstrual age using the cluster scores for motor development and vigor and alertness/orientation from the Neurobehavioral Assessment of the Preterm Infant. Multiple linear regression models with robust standard errors were used to analyze the data. Average levels of individual cytokines, cytokine trends, and composite scores were used as measures of inflammation.

10/06/2024


Biochemical remission (BR), gross total resection (GTR), and intraoperative cerebrospinal fluid (CSF) leaks are important metrics in transsphenoidal surgery for acromegaly, and prediction of their likelihood using machine learning would be clinically advantageous. We aim to develop and externally validate clinical prediction models for outcomes after transsphenoidal surgery for acromegaly.

Using data from two registries, we develop and externally validate machine learning models for GTR, BR, and CSF leaks after endoscopic transsphenoidal surgery in acromegalic patients. For the model development a registry from Bologna, Italy was used. External validation was then performed using data from Zurich, Switzerland. Gender, age, prior surgery, as well as Hardy and Knosp classification were used as input features. Discrimination and calibration metrics were assessed.

The derivation cohort consisted of 307 patients (43.3% male; mean [SD] age, 47.2 [12.7] years). GTR was achieved in 226 (73.6%) and BR in 245 (79rgical therapy. We demonstrate the feasibility of developing and externally validating clinical prediction models for these outcomes after surgery for acromegaly and lay the groundwork for development of a multicenter model with more robust generalization.Carney complex is a rare syndrome caused by a genetic mutation leading to multiple endocrine abnormalities and a variety of tumors. Here, we report a case of Carney complex diagnosed due to recurrent multiple myxomas in the right atrium of a patient 16 years after the resection of the primary left atrial myxoma. Surgical excision was performed for the multiple recurrent right atrial tumors under cardiopulmonary bypass. The patient remained complication-free after surgery and was discharged on the 14th day. He was scheduled to continue echocardiographic follow-up and periodic systemic review by an endocrinologist. This case emphasizes the fact that if cardiac myxomas tend to be multiple and recurrent at a relatively young age, the possibility of Carney complex should be considered, even in the absence of any other related feature other than cardiac tumors.Intracellular quality control regulated by autophagy process is important for maintenance of cellular homeostasis. Deregulation of autophagy and more specifically mitophagy leads to accumulation of the misfolded proteins and damaged mitochondria that in turn leads to the cell loss. Alteration of autophagy and mitophagy has shown to be involved in the number of disorders including neurodegenerative diseases. Autophagy and mitophagy could be activated by short-time acidification of the cytosol; however, most of the compounds which can induce it are toxic. Here, we tested several organic compounds which are involved in cellular metabolism on their ability to change intracellular pH and induce mitophagy/autophagy. We have found that lactate and pyruvate are able to reduce intracellular pH in non-toxic concentrations. Short-term (2 h) and long-term (24 h) incubation of the cells with lactate and pyruvateinduced mitophagy and autophagy. Incubation of the SH-SY5Y cells or primary neurons and astrocytes with lactate or pyruvate also activated mitophagy and autophagy after MPP + treatment that led to recovery of mitochondrial function and protection of these cells against apoptotic and necrotic death. Thus, pyruvate- or lactate-induced acidification of cytosol activates cell protective mitophagy and autophagy.Four substantial topics are explored in this issue of the Journal of Religion and Health, namely (1) Christianity, (2) family and faith dynamics, (3) the spiritual and religious experiences of students from Islamic, Christian, Buddhist, Hindu, and Jewish perspectives, and lastly, (4) the lingering effects of COVID-19. This issue also notes the diamond jubilee-60th year-of JORH (2021).
Anticipated and experienced stigma constitute important issues for patients with multiple sclerosis receiving adequate healthcare. Stigma is likely to be associated with lower quality of life in patients with multiple sclerosis, but the underlying mechanisms and contributing factors are unclear.

We conducted a cross-sectional survey among N = 101 patients with a diagnosis of multiple sclerosis in a German outpatient department. Patients completed questionnaires on enacted and self-stigma (SSCI-8), sense of coherence (SOC-L9) and quality of life (MusiQol). Age, sex, disease duration, disability or extent of limitations (EDSS), cognition (SDMT), depression (BDI-II) and fatigue (FSMC) were used as covariates in linear regression and mediation models.

57.3% of patients with MS reported having experienced stigmatization due to MS at least once. Fatigue (b = -0.199, p < 0.001), enacted stigmatization experience (b = -0.627, p = 0.010) and sense of coherence (b = 0.654, p < 0.001) were significant predictors for quality of life. The mediation analysis showed a partial mediation of the association between enacted stigma and quality of life by patients' sense of coherence (direct effect b = -1.042, t = -4.021, p < 0.001; indirect effect b = -0.773, CI = -1.351--0.339. The association of self-stigma with quality of life was fully mediated by sense of coherence (b = -1.579, CI = -2.954--0.669).

Patients with multiple sclerosis are affected by stigma, which is associated with lower quality of life. Sense of coherence is a potentially important mediator of stigma and represents a promising target to refine existing stigma interventions and improve the quality of life in these patients.
Patients with multiple sclerosis are affected by stigma, which is associated with lower quality of life. Sense of coherence is a potentially important mediator of stigma and represents a promising target to refine existing stigma interventions and improve the quality of life in these patients.
Pandemics can generate considerable distress, which can affect prevention behaviors. Resilience may buffer the negative effects of distress on engagement in relevant prevention behaviors, which may also hold true for COVID-19 prevention behaviors. The objective of the current study was to evaluate whether resilience moderated the relationship between distress and COVID-19 prevention behaviors early in the pandemic.

Data were collected via surveys in which all students at a large midwestern university were emailed invitations beginning March 18, 2020. https://www.selleckchem.com/products/erastin.html Surveys were completed by 5,530 individuals. In addition to demographic questions and items about COVID-19 prevention behaviors, distress was assessed using the K6 Distress Scale and resilience using the Brief Resilience Scale. Data were analyzed using moderator regression analysis.

Resilience moderates the effects from distress to prevention behaviors, such that the relationship was stronger for individuals with higher resilience than for individuals with ng individuals to engage in a greater number of disease-related prevention behaviors. Future research should examine this relationship longitudinally and in relation to differing constructs of resilience.Seasonal tissue concentrations of heavy metals, antioxidant enzymes, immunological components, and water quality parameters were investigated during 1 year in the ark clam, Barbatia decussate, from the coast of Lengeh port, located in the north of the Persian Gulf, Iran. The tissue accumulation of the heavy metals (Cd, Pb, Hg) significantly increased accumulations in late autumn and winter (P  0.01). Seasonal changes were also observed in metal-induced biochemical components. In this regard, the malondialdehyde (MDA) levels and the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) elevated throughout spring and summer and then declined during autumn and winter (P  less then  0.01). Phagocytosis activity significantly decreased from December to February and then increased from March to September (P  less then  0.01). Total hemocyte counts decreased from October to March and then elevated until April (P  less then  0.01). Significant relationships were found between tissue heavy metal concentrations, water quality parameters, and biochemical components (P  less then  0.01). The negative correlations were O2 vs. antioxidant enzymes, phagocytosis, and total counts of the hemocytes (THCs); pH vs. SOD; salinity vs. Cr; and temperature vs. GPx and Ni. Positive correlations were O2 vs. Cd, Pb, Hg, and Ni; temperature vs. phagocytosis and THCs; and turbidity vs. link2 phagocytosis, THCs, CAT, and GPx. The results of the present study showed a seasonal pattern in the accumulation of heavy metals, with maximum levels in winter for the ark clam, B. decussate . Furthermore, antioxidant defense and immunity of B. decussate are reduced during winter, which may make B. decussate susceptible to diseases.Particulate matter is usually regarded as the dominant pollutant in Tehran megacity in Iran. However, the number of ozone exceedance days significantly increased in recent years. This study analyzes simultaneous measurements of O3 and NOx (NO+NO2) concentrations to improve our understanding of ozone evolution during the summers of 2017 to 2019. The k-means clustering technique was used to select five representative air quality monitoring sites in Tehran to capture O3 and NOx concentrations' variability. The findings show that all of the investigated sites failed to meet the ozone non-attainment criterion. link3 The ozone weekend effect is seen in the study of weekday/weekend differences in 2017 and 2018, but not in 2019, which can be due to the shift in the ozone production regime. The summer mean variation analysis can also be used to deduce this regime change. In 2017, the O3 and NO2 summer mean variations suggest a holdback in the NO2 upward trend and a reversal in the O3 downward trend that had been in place since 2012. Air mass back trajectory clustering reveals that east and north-east air mass clusters have the most significant impact on Tehran's O3 pollution and the highest regional contribution to OX. The study of OX against NOx shows that the regional contribution to OX increased from 2017 to 2018 and then decreased in 2019; however, the local contribution is the opposite. The diurnal analysis of the regional and local contributions to OX indicated that OX in Tehran might be primarily affected by pollutants from a short distance. The findings reveal critical changes in the behavior of O3 in recent years, indicating that decision-makers in Tehran should reconsider air pollution control measures.Phytoremediation represents a natural method to remove contaminants from soil. The goal of this study was to investigate the potential of phosphate-assisted phytoremediation by two energy crops, Cannabis sativa L. and Brassica juncea L., for the sustainable remediation of heavily arsenic-contaminated industrial soil. The two species were investigated for uptake, translocation, and physiological effects of arsenic and phosphate in a microcosm test. Although C. sativa and B. juncea were symptomless when grown in arsenic-contaminated soil, an important reduction of biomass (50 and 25%, respectively) was observed as a stress marker. Phytotoxicity and cytotoxicity effects promoted by contaminated soils were investigated in both the species and a model plant for ecotoxicity studies, Vicia faba L., which is the most developed model to test genotoxicity effects in terms of chromosomal aberration and micronuclei presence. The higher amount of arsenic was found in C. sativa and B. juncea roots (on average 1473 and 778 mg kg-1, respectively), but both species were able to uptake and translocate arsenic in leaves and stems, up to 47.

10/05/2024


llers were satisfied, corroborating literature from pre-pandemic contexts. The satisfaction and acceptability of the service does not supplant preferences for in-person visits. The survey sample reported lower quality of life compared with the provincial population, conflicting with pre-pandemic research. Findings may be due to added stressors associated with the pandemic. Future research should include population-level comparators to better clarify impact.
Asymptomatic and high-risk COVID-19 patients are advised to self-isolate at home. However, patients may not realize that the condition is deteriorating until too late.

This study aims to review various artificial intelligence-based telemedicine research during the COVID-19 outbreak and proposes a framework for developing telemedicine powered by artificial intelligence to monitor progression in COVID-19 patients during isolation at home. It also aims to map challenges using artificial intelligence-based telemedicine in the community.

A systematic review was performed for the related articles published in 2019-2021 and conducted in the PubMed and ScienceDirect database using the keywords "telemedicine," "artificial intelligence," and "COVID-19". The inclusion criteria were full-text articles and original research written in the English language.

Thirteen articles were included in this review to describe the current application of artificial intelligence-based telemedicine during the COVID-19 pandemic. Vnals also need to adapt to these advances for better healthcare delivery to the public.Glutamate (GLU) and gamma-aminobutyric acid (GABA) are neurotransmitters (NTs) with an essential role in signal transmission in the brain. Brain disorders, such as epilepsy, Alzheimer's and Parkinson's diseases, and traumatic brain injury can be linked to imbalances in the GLU-GABA homeostasis that occurs in sub-second to seconds time frames. Current measurement techniques can detect these two NT concentrations simultaneously only in vitro. The present work reports on the fabrication of a silicon multifunctional biosensor microarray probe for sub-second simultaneous GLU-GABA detection in real-time, with excellent analyte sensitivity and selectivity and in vivo capabilities. The novel Si probes feature four surface-functionalized platinum ultramicroelectrodes (UMEs) for simultaneous amperometric detection of GLU and GABA with a sentinel, and a built-in microfluidic channel for the introduction of neurochemicals in the proximity of the UMEs. The microchannel also allows functioning of an On-Demand In-situ Calibrator that runs in-situ biosensor calibration. The probe exhibited excellent robustness at insertion in agarose-gel brain-tissue-mimicking test, and remarkably high hydrogen peroxide sensitivity (a by-product of GLU-GABA enzyme biosensor) with values on the order of 5000 nA μM -1 cm -2 and maximum sensitivities of 204±15 nA μM -1 cm -2 and 37±7 nA μM -1 cm -2 for GLU and GABA, respectively. Furthermore, the limit of detection of the biosensors reached as low as 7 nM, 165 nM and 750 nM for H 2 O 2, GLU and GABA, respectively and a temporal resolution of hundreds of milliseconds during in vivo studies using freely moving rats.The COVID-19 pandemic has spread around the world, disrupting economies, societies and daily life. Early research anticipated significant negative impacts for the globalized seafood supply network. Here, we explore the impact of the COVID-19 pandemic on wholesale prices from five major seafood markets around the world. An anomalies analysis was used to establish a 5-year baseline price for each commodity. Daily price data from 2020 were compared to the baseline to identify collapses (>1.96 SE from baseline) and analyse collapse characteristics (timing, duration and magnitude). Non-uniform price collapses were observed across, and within, the markets analysed. Toyosu (Tokyo) Market experienced price collapses to 51% of commodities, Rungis (Paris) 36%, Mercamadrid (Madrid) 19%, Mercado La Nueva Viga (Mexico City) 35% and the Portland Fish Exchange (Portland, Maine) 32%. Collapse magnitude varied from 11% to 79% of the 5-year average price. Average collapse duration ranged from 13 to 24 weeks with some commodities (4%-22%) remaining collapsed at the end of 2020. For markets where volume data were available, collapses were also noted (59% of commodities in Toyosu, 10% in Mercamadrid and 19% in Portland Fish Exchange); in these cases, the volume collapse was more severe than the related price collapse. To better detect, anticipate and respond to future shocks, we recommend that relevant government agencies conduct comprehensive economic reviews of the COVID-19 pandemic throughout the seafood supply chain, including the outcomes of emergency measures, short- and long-term implications of market volatility and identify areas of supply and labour vulnerabilities.This article presents the immense impact that pandemics can have specifically on consumers' mental well-being, extending many of the well-being topics examined in this special issue on pandemics and consumer well-being. Avenues for future research in the area are suggested, with expanded discussion and future research suggestions related to four consumer characteristics including three areas associated with negative mental well-being (parenthood, suffering with chronic illness, aging, and family) as well as another characteristic associated with positive mental well-being (religion). The article concludes with a pressing call to action for academics and others to step up to the purpose in their careers and make a difference in the world for good in relation to consumers' mental well-being.This article advances the riveting discussion on how this special issue contributes to the consumer well-being literature. Specifically, this article endeavors to present an eclectic account of how the pandemics has had a lasting impact on the consumer well-being, its provenance and future research priorities for academics and practice. First, it briefly discusses the origin and relevance of the evolving issue of consumer well-being during pandemics. Second, it presents several directions for future research and third, it offers key insights for policymakers. It includes multiple research priorities that present vastly contrasting manifestations of consumer well-being. This article argues that future research will need to examine the drivers of consumer well-being during pandemics, the mechanisms that underlie the influence of pandemics on consumer well-being and the boundary conditions that accentuate/mitigate the influence of pandemic-induced factors.The COVID-19 pandemic brought grave financial concerns for families in the United States as they attempted to navigate the multifaceted impacts of the pandemic. The present descriptive study examined Florida families' employment characteristics, credit card debt, savings characteristics, use of savings based on employment and income variables, and patterns of use of the first 2020 economic impact payment during the early stages of the COVID-19 pandemic. Responses to an online questionnaire were collected from 526 Florida residents, age 18 or older, who were parents of minor children during the time the study was conducted. Findings are indicative of varying financial impacts on families based on gender, marital status, income level, and employment status related to COVID-19. Implications are presented for employers, educators, researchers, policymakers, and families.The impact of the COVID-19 pandemic on the overall well-being of consumers is disastrous. However, there is limited understanding of how the COVID-19 situation affects consumer well-being and how subsistence consumers mitigate well-being concerns and unique stresses. Following an exploratory, qualitative approach, 39 in-depth semi-structured interviews with subsistence consumers were conducted in India and Bangladesh. Findings from the thematic analysis reveal that subsistence consumers experienced unique stresses and hardships during COVID-19, which are unforeseen transitory financial stress, psychosocial stress, and marketplace and consumption-related stresses. Drawing on the appraisal theory of stress, our analysis of the data identifies the co-existence of two emotion-focused coping strategies-religiosity and social support-that interplay to overcome their well-being concerns in the emerging countries of India and Bangladesh. https://www.selleckchem.com/products/ly3039478.html Therefore, it may be of particular interest to managers and policymakers who seek to address the severe consequences of the COVID-19 pandemic on socio-economically subsistence consumers.The Coronavirus (COVID-19) pandemic reduced real and perceived access to healthcare services, exacerbating pandemic fear, and thus influencing consumers' adoption of preventative health behaviors. Extending the EHBM, results from two studies show that perceived access to health services and pandemic fear impact an individual's general and COVID-preventative health behaviors. High perceived access reduces pandemic fear through its buffering effects on perceived health vulnerability and pandemic-related health system concern, especially with telehealth usage during the pandemic. While pandemic fear motivates COVID-19 vaccination, pandemic fear reduces personal preventative health behavior (e.g., healthy eating, exercising) and has little effect on personal COVID-preventative behaviors (e.g., wearing a mask, social distancing) when individuals perceive high pandemic-related control. Moreover, the fear-behavior link does not hold for preventative health visits; instead, perceived access directly promotes preventative visits and screening. This research informs public health stakeholders' communication, education, and resource allocation during health crises like the COVID-19 pandemic.The COVID-19 pandemic has fundamentally changed the world and inevitably influenced people's behaviors including the likelihood of crime and deviance. Emerging empirical evidence suggests a decline in certain crimes (e.g., theft, robbery, and assault) but also proliferation of different violent behaviors and cybercriminal activity during the pandemic. To explain those trends, we draw on existent theories and elaborate on how crime and violence have been affected by the changes in people's daily routines and accumulated stressful conditions. However, as recent crime trends appear to be largely inconsistent and vary across social groups and contexts, we argue that social scientists need to pay particular attention to the differential experiences related to crime and violence during this global crisis. Specifically, because of the disproportionate experience of violence by vulnerable groups including minorities and women as well as the unique cross-national variations in deviance, more nuanced approaches to understanding causes of crime are warranted. We also discuss the limitations of present research and provide recommendations for the development of comparative and multi-disciplinary studies on criminal and deviant behaviors that are influenced by human crisis situations.As the COVID-19 pandemic turns two how should those who feel like we have been responsible neighbors (kept our distance, worn our masks, availed ourselves to the vaccine) respond to those we feel have not been-and specifically toward those who have refused the vaccine as a sign of political loyalty? How might those of us tempted to react from anger cultivate an alternative response? This paper explores the texts of two religions traditions-Mahāyāna Buddhism's Bodhicaryāvatāra and Christianity's Gospel of John-searching for resources for a response other than anger and blame.

Videos

05/05/2023

A debate about some of the most controversial issues is happening in the Christian faith and it is causing some to question the future of the Church. Scottie Nell Hughes speaks to Deacon Calvin Robinson of the Anglican Church on this episode of 360 View. We are going to look at the divide happening within the Christian Church and what effect the Church’s demise could have globally.

04/10/2023

GOP presidential candidate Vivek Ramasamy joined Timcast this weekend to share his thoughts on the role that God plays in helping people feel purpose in their lives.

"One of my favorite scientists, Blaise Pascal, said it best: if you have a hole the size of God in your heart & God doesn’t fill it, something else will."

You follow Vivek on Twitter @VivekGRamaswamy

02/24/2023

“God is gay. God is a lesbian. God is trans. God is gender non-binary.”

Most religionists who make ridiculous claims such as these secretly believe that God is fake. He means nothing to them, which is why they feel so comfortable making Him whatever they need to advance their cultural agenda.

People

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Circles

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05/05/2023

A debate about some of the most controversial issues is happening in the Christian faith and it is causing some to question the future of the Church. Scottie Nell Hughes speaks to Deacon Calvin Robinson of the Anglican Church on this episode of 360 View. We are going to look at the divide happening within the Christian Church and what effect the Church’s demise could have globally.

04/10/2023

GOP presidential candidate Vivek Ramasamy joined Timcast this weekend to share his thoughts on the role that God plays in helping people feel purpose in their lives.

"One of my favorite scientists, Blaise Pascal, said it best: if you have a hole the size of God in your heart & God doesn’t fill it, something else will."

You follow Vivek on Twitter @VivekGRamaswamy

02/24/2023

“God is gay. God is a lesbian. God is trans. God is gender non-binary.”

Most religionists who make ridiculous claims such as these secretly believe that God is fake. He means nothing to them, which is why they feel so comfortable making Him whatever they need to advance their cultural agenda.

12/21/2022

Check out our partner for this episode, www.createtailwind.com

Zelensky arrives in U.S. to ask Congress for 45 Billion dollars in additional aid, only days after he moves to ban the Ukrainian Orthodox Church. So why are some still claiming he is a Defender of Freedom?

Posts

22 hrs ago


Nowadays, novel less-expensive nanoformulations for in situ-controlled and safe delivery of photosensitisers (PSs) against opportunistic pathogens in body-infections areas need to be developed. Antimicrobial photodynamic therapy (aPDT) is a promising approach to treat bacterial infections that are recalcitrant to antibiotics. In this paper, we propose the design and characterization of a novel nanophototherapeutic based on the trade cyclodextrin CAPTISOL® (sulfobutylether-beta-cyclodextrin, SBE-βCD) and 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphine tetrakis(p-toluenesulfonate) (TMPyP) to fabricate efficient biocompatible systems for aPDT. Spherical nanoassemblies of about 360 nm based on CAPTISOL®/TMPyP supramolecular complexes with 11 stoichiometry and apparent equilibrium binding constant (Kb ≅ 1.32 × 105 M-1) were prepared with entrapment efficiency of ≅ 100% by simple mixing in aqueous media and freeze-drying. These systems have been characterized by complementary spectroscopy and microscopy technility thus optimizing the PDT effect at the site of action. These results can open routes for in vivo translational studies on nano(photo)drugs and nanotheranostics based on less expensive formulations of CD and PS.Transient local over-dry environment might be a contributor and an explanation for the observed asynchronous local rises in Covid-19 mortality. We propose that a habitat's air humidity negatively correlate with Covid-19 morbidity and mortality, and support this hypothesis on the example of publicly available data from German federal states.SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19. DEC has inhibitory effects on arachidonic acid metabolism to prostaglandins, little known anti-viral effects on animal retroviruses and demonstrated anti-inflammatory actions in animal models of lung inflammation indicating the need to explore this hypothesis further. We believe this is the first time DEC is being proposed to treat COVID-19.The discovery of the 2,000-year-old Dead Sea Scrolls had an incomparable impact on the historical understanding of Judaism and Christianity. "Piecing together" scroll fragments is like solving jigsaw puzzles with an unknown number of missing parts. We used the fact that most scrolls are made from animal skins to "fingerprint" pieces based on DNA sequences. Genetic sorting of the scrolls illuminates their textual relationship and historical significance. Disambiguating the contested relationship between Jeremiah fragments supplies evidence that some scrolls were brought to the Qumran caves from elsewhere; significantly, they demonstrate that divergent versions of Jeremiah circulated in parallel throughout Israel (ancient Judea). Similarly, patterns discovered in non-biblical scrolls, particularly the Songs of the Sabbath Sacrifice, suggest that the Qumran scrolls represent the broader cultural milieu of the period. Finally, genetic analysis divorces debated fragments from the Qumran scrolls. Our study demonstrates that interdisciplinary approaches enrich the scholar's toolkit.Mycolic acid methyl esters were extracted from Mycobacterium avium by a mild saponification protocol, designed to preserve labile components. The resulting mixture of α-, keto- and wax ester mycolates was accompanied by some degraded ω-carboxymycolic acid dimethyl esters, whose overall structures were found to support previous studies. Chromatography of the mono-carboxylic mycolates gave an inseparable mixture of keto- and wax ester mycolates and separate α-mycolates. Reduction of the ketomycolate components allowed isolation and characterisation of intact wax ester mycolates for the first time. Minor α- and ω-carboxymycolates were detected in which methyl branches were located on either the proximal or distal sides of trans-alkene groups.Background Brown tumors are giant cell-rich lesions that result from abnormal bone metabolism in hyperparathyroidism, one of the most common endocrine disorders worldwide. Brown tumors occasionally affect the jaws and, despite well-known clinical and microscopic features, their molecular pathogenesis remains unclear. We investigated the presence of pathogenic activating mutations in TRPV4, FGFR1, and KRAS in a cohort of brown tumors since these have recently been reported in giant-cell lesions of the jaws and non-ossifying fibromas of the bones (FGFR1 and KRAS), which are histologic mimics of brown tumors. Methods We target sequenced 13 brown tumors of the jaws associated with primary or secondary hyperparathyroidism. As mutations in these genes are known to activate the MAPK/ERK signaling pathway, we also assessed the immunostaining of the phosphorylated form of ERK1/2 (pERK1/2) in these lesions. Results KRAS pathogenic mutations were detected in seven cases (p.G12V n = 4, p.G12D n = 1, p.G13D n = 1, p.A146T n = 1). KRAS variants of unknown significance (VUS), p.A134T and p.E37K, were also detected. All samples showed wild-type sequences for FGFR1 and TRPV4 genes. The activation of the MAPK/ERK signaling pathway was demonstrated by pERK1/2 immunohistochemical positivity of the brown tumors´ mononuclear cells. Conclusion Mutations in KRAS and activation of the MAPK/ERK signaling pathway were detected in brown tumors of hyperparathyroidism of the jaws, expanding the spectrum of giant cell lesions whose molecular pathogenesis involve RAS signaling.In the era of a pandemic, networking opportunities have evaporated, and researchers are reinventing ways to connect with the community. It is our pleasure to build some of those connections, especially for young authors, by introducing you to eleven scientists whose work is featured in this issue. https://www.selleckchem.com/products/rin1.html Here, they share their diverse and splendid journeys-from early concepts to the fruition of published work.Background Preterm infants are at risk for impaired neurodevelopment. Inflammation may be an important modifiable mediator of preterm birth and neurodevelopmental impairment, but few studies have examined longitudinal measures of inflammation. Objective To determine the relationship between longitudinal measures of inflammation and neurobehavior in very preterm infants. Study design Non-experimental, repeated measures cohort study. Methods Very preterm infants were enrolled between October 2017 and December 2018. Blood was collected weekly until 35 weeks post-menstrual age for the quantification of plasma cytokines. Neurobehavior was assessed at 35 weeks post-menstrual age using the cluster scores for motor development and vigor and alertness/orientation from the Neurobehavioral Assessment of the Preterm Infant. Multiple linear regression models with robust standard errors were used to analyze the data. Average levels of individual cytokines, cytokine trends, and composite scores were used as measures of inflammation.

10/06/2024


Biochemical remission (BR), gross total resection (GTR), and intraoperative cerebrospinal fluid (CSF) leaks are important metrics in transsphenoidal surgery for acromegaly, and prediction of their likelihood using machine learning would be clinically advantageous. We aim to develop and externally validate clinical prediction models for outcomes after transsphenoidal surgery for acromegaly.

Using data from two registries, we develop and externally validate machine learning models for GTR, BR, and CSF leaks after endoscopic transsphenoidal surgery in acromegalic patients. For the model development a registry from Bologna, Italy was used. External validation was then performed using data from Zurich, Switzerland. Gender, age, prior surgery, as well as Hardy and Knosp classification were used as input features. Discrimination and calibration metrics were assessed.

The derivation cohort consisted of 307 patients (43.3% male; mean [SD] age, 47.2 [12.7] years). GTR was achieved in 226 (73.6%) and BR in 245 (79rgical therapy. We demonstrate the feasibility of developing and externally validating clinical prediction models for these outcomes after surgery for acromegaly and lay the groundwork for development of a multicenter model with more robust generalization.Carney complex is a rare syndrome caused by a genetic mutation leading to multiple endocrine abnormalities and a variety of tumors. Here, we report a case of Carney complex diagnosed due to recurrent multiple myxomas in the right atrium of a patient 16 years after the resection of the primary left atrial myxoma. Surgical excision was performed for the multiple recurrent right atrial tumors under cardiopulmonary bypass. The patient remained complication-free after surgery and was discharged on the 14th day. He was scheduled to continue echocardiographic follow-up and periodic systemic review by an endocrinologist. This case emphasizes the fact that if cardiac myxomas tend to be multiple and recurrent at a relatively young age, the possibility of Carney complex should be considered, even in the absence of any other related feature other than cardiac tumors.Intracellular quality control regulated by autophagy process is important for maintenance of cellular homeostasis. Deregulation of autophagy and more specifically mitophagy leads to accumulation of the misfolded proteins and damaged mitochondria that in turn leads to the cell loss. Alteration of autophagy and mitophagy has shown to be involved in the number of disorders including neurodegenerative diseases. Autophagy and mitophagy could be activated by short-time acidification of the cytosol; however, most of the compounds which can induce it are toxic. Here, we tested several organic compounds which are involved in cellular metabolism on their ability to change intracellular pH and induce mitophagy/autophagy. We have found that lactate and pyruvate are able to reduce intracellular pH in non-toxic concentrations. Short-term (2 h) and long-term (24 h) incubation of the cells with lactate and pyruvateinduced mitophagy and autophagy. Incubation of the SH-SY5Y cells or primary neurons and astrocytes with lactate or pyruvate also activated mitophagy and autophagy after MPP + treatment that led to recovery of mitochondrial function and protection of these cells against apoptotic and necrotic death. Thus, pyruvate- or lactate-induced acidification of cytosol activates cell protective mitophagy and autophagy.Four substantial topics are explored in this issue of the Journal of Religion and Health, namely (1) Christianity, (2) family and faith dynamics, (3) the spiritual and religious experiences of students from Islamic, Christian, Buddhist, Hindu, and Jewish perspectives, and lastly, (4) the lingering effects of COVID-19. This issue also notes the diamond jubilee-60th year-of JORH (2021).
Anticipated and experienced stigma constitute important issues for patients with multiple sclerosis receiving adequate healthcare. Stigma is likely to be associated with lower quality of life in patients with multiple sclerosis, but the underlying mechanisms and contributing factors are unclear.

We conducted a cross-sectional survey among N = 101 patients with a diagnosis of multiple sclerosis in a German outpatient department. Patients completed questionnaires on enacted and self-stigma (SSCI-8), sense of coherence (SOC-L9) and quality of life (MusiQol). Age, sex, disease duration, disability or extent of limitations (EDSS), cognition (SDMT), depression (BDI-II) and fatigue (FSMC) were used as covariates in linear regression and mediation models.

57.3% of patients with MS reported having experienced stigmatization due to MS at least once. Fatigue (b = -0.199, p < 0.001), enacted stigmatization experience (b = -0.627, p = 0.010) and sense of coherence (b = 0.654, p < 0.001) were significant predictors for quality of life. The mediation analysis showed a partial mediation of the association between enacted stigma and quality of life by patients' sense of coherence (direct effect b = -1.042, t = -4.021, p < 0.001; indirect effect b = -0.773, CI = -1.351--0.339. The association of self-stigma with quality of life was fully mediated by sense of coherence (b = -1.579, CI = -2.954--0.669).

Patients with multiple sclerosis are affected by stigma, which is associated with lower quality of life. Sense of coherence is a potentially important mediator of stigma and represents a promising target to refine existing stigma interventions and improve the quality of life in these patients.
Patients with multiple sclerosis are affected by stigma, which is associated with lower quality of life. Sense of coherence is a potentially important mediator of stigma and represents a promising target to refine existing stigma interventions and improve the quality of life in these patients.
Pandemics can generate considerable distress, which can affect prevention behaviors. Resilience may buffer the negative effects of distress on engagement in relevant prevention behaviors, which may also hold true for COVID-19 prevention behaviors. The objective of the current study was to evaluate whether resilience moderated the relationship between distress and COVID-19 prevention behaviors early in the pandemic.

Data were collected via surveys in which all students at a large midwestern university were emailed invitations beginning March 18, 2020. https://www.selleckchem.com/products/erastin.html Surveys were completed by 5,530 individuals. In addition to demographic questions and items about COVID-19 prevention behaviors, distress was assessed using the K6 Distress Scale and resilience using the Brief Resilience Scale. Data were analyzed using moderator regression analysis.

Resilience moderates the effects from distress to prevention behaviors, such that the relationship was stronger for individuals with higher resilience than for individuals with ng individuals to engage in a greater number of disease-related prevention behaviors. Future research should examine this relationship longitudinally and in relation to differing constructs of resilience.Seasonal tissue concentrations of heavy metals, antioxidant enzymes, immunological components, and water quality parameters were investigated during 1 year in the ark clam, Barbatia decussate, from the coast of Lengeh port, located in the north of the Persian Gulf, Iran. The tissue accumulation of the heavy metals (Cd, Pb, Hg) significantly increased accumulations in late autumn and winter (P  0.01). Seasonal changes were also observed in metal-induced biochemical components. In this regard, the malondialdehyde (MDA) levels and the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) elevated throughout spring and summer and then declined during autumn and winter (P  less then  0.01). Phagocytosis activity significantly decreased from December to February and then increased from March to September (P  less then  0.01). Total hemocyte counts decreased from October to March and then elevated until April (P  less then  0.01). Significant relationships were found between tissue heavy metal concentrations, water quality parameters, and biochemical components (P  less then  0.01). The negative correlations were O2 vs. antioxidant enzymes, phagocytosis, and total counts of the hemocytes (THCs); pH vs. SOD; salinity vs. Cr; and temperature vs. GPx and Ni. Positive correlations were O2 vs. Cd, Pb, Hg, and Ni; temperature vs. phagocytosis and THCs; and turbidity vs. link2 phagocytosis, THCs, CAT, and GPx. The results of the present study showed a seasonal pattern in the accumulation of heavy metals, with maximum levels in winter for the ark clam, B. decussate . Furthermore, antioxidant defense and immunity of B. decussate are reduced during winter, which may make B. decussate susceptible to diseases.Particulate matter is usually regarded as the dominant pollutant in Tehran megacity in Iran. However, the number of ozone exceedance days significantly increased in recent years. This study analyzes simultaneous measurements of O3 and NOx (NO+NO2) concentrations to improve our understanding of ozone evolution during the summers of 2017 to 2019. The k-means clustering technique was used to select five representative air quality monitoring sites in Tehran to capture O3 and NOx concentrations' variability. The findings show that all of the investigated sites failed to meet the ozone non-attainment criterion. link3 The ozone weekend effect is seen in the study of weekday/weekend differences in 2017 and 2018, but not in 2019, which can be due to the shift in the ozone production regime. The summer mean variation analysis can also be used to deduce this regime change. In 2017, the O3 and NO2 summer mean variations suggest a holdback in the NO2 upward trend and a reversal in the O3 downward trend that had been in place since 2012. Air mass back trajectory clustering reveals that east and north-east air mass clusters have the most significant impact on Tehran's O3 pollution and the highest regional contribution to OX. The study of OX against NOx shows that the regional contribution to OX increased from 2017 to 2018 and then decreased in 2019; however, the local contribution is the opposite. The diurnal analysis of the regional and local contributions to OX indicated that OX in Tehran might be primarily affected by pollutants from a short distance. The findings reveal critical changes in the behavior of O3 in recent years, indicating that decision-makers in Tehran should reconsider air pollution control measures.Phytoremediation represents a natural method to remove contaminants from soil. The goal of this study was to investigate the potential of phosphate-assisted phytoremediation by two energy crops, Cannabis sativa L. and Brassica juncea L., for the sustainable remediation of heavily arsenic-contaminated industrial soil. The two species were investigated for uptake, translocation, and physiological effects of arsenic and phosphate in a microcosm test. Although C. sativa and B. juncea were symptomless when grown in arsenic-contaminated soil, an important reduction of biomass (50 and 25%, respectively) was observed as a stress marker. Phytotoxicity and cytotoxicity effects promoted by contaminated soils were investigated in both the species and a model plant for ecotoxicity studies, Vicia faba L., which is the most developed model to test genotoxicity effects in terms of chromosomal aberration and micronuclei presence. The higher amount of arsenic was found in C. sativa and B. juncea roots (on average 1473 and 778 mg kg-1, respectively), but both species were able to uptake and translocate arsenic in leaves and stems, up to 47.

10/05/2024


llers were satisfied, corroborating literature from pre-pandemic contexts. The satisfaction and acceptability of the service does not supplant preferences for in-person visits. The survey sample reported lower quality of life compared with the provincial population, conflicting with pre-pandemic research. Findings may be due to added stressors associated with the pandemic. Future research should include population-level comparators to better clarify impact.
Asymptomatic and high-risk COVID-19 patients are advised to self-isolate at home. However, patients may not realize that the condition is deteriorating until too late.

This study aims to review various artificial intelligence-based telemedicine research during the COVID-19 outbreak and proposes a framework for developing telemedicine powered by artificial intelligence to monitor progression in COVID-19 patients during isolation at home. It also aims to map challenges using artificial intelligence-based telemedicine in the community.

A systematic review was performed for the related articles published in 2019-2021 and conducted in the PubMed and ScienceDirect database using the keywords "telemedicine," "artificial intelligence," and "COVID-19". The inclusion criteria were full-text articles and original research written in the English language.

Thirteen articles were included in this review to describe the current application of artificial intelligence-based telemedicine during the COVID-19 pandemic. Vnals also need to adapt to these advances for better healthcare delivery to the public.Glutamate (GLU) and gamma-aminobutyric acid (GABA) are neurotransmitters (NTs) with an essential role in signal transmission in the brain. Brain disorders, such as epilepsy, Alzheimer's and Parkinson's diseases, and traumatic brain injury can be linked to imbalances in the GLU-GABA homeostasis that occurs in sub-second to seconds time frames. Current measurement techniques can detect these two NT concentrations simultaneously only in vitro. The present work reports on the fabrication of a silicon multifunctional biosensor microarray probe for sub-second simultaneous GLU-GABA detection in real-time, with excellent analyte sensitivity and selectivity and in vivo capabilities. The novel Si probes feature four surface-functionalized platinum ultramicroelectrodes (UMEs) for simultaneous amperometric detection of GLU and GABA with a sentinel, and a built-in microfluidic channel for the introduction of neurochemicals in the proximity of the UMEs. The microchannel also allows functioning of an On-Demand In-situ Calibrator that runs in-situ biosensor calibration. The probe exhibited excellent robustness at insertion in agarose-gel brain-tissue-mimicking test, and remarkably high hydrogen peroxide sensitivity (a by-product of GLU-GABA enzyme biosensor) with values on the order of 5000 nA μM -1 cm -2 and maximum sensitivities of 204±15 nA μM -1 cm -2 and 37±7 nA μM -1 cm -2 for GLU and GABA, respectively. Furthermore, the limit of detection of the biosensors reached as low as 7 nM, 165 nM and 750 nM for H 2 O 2, GLU and GABA, respectively and a temporal resolution of hundreds of milliseconds during in vivo studies using freely moving rats.The COVID-19 pandemic has spread around the world, disrupting economies, societies and daily life. Early research anticipated significant negative impacts for the globalized seafood supply network. Here, we explore the impact of the COVID-19 pandemic on wholesale prices from five major seafood markets around the world. An anomalies analysis was used to establish a 5-year baseline price for each commodity. Daily price data from 2020 were compared to the baseline to identify collapses (>1.96 SE from baseline) and analyse collapse characteristics (timing, duration and magnitude). Non-uniform price collapses were observed across, and within, the markets analysed. Toyosu (Tokyo) Market experienced price collapses to 51% of commodities, Rungis (Paris) 36%, Mercamadrid (Madrid) 19%, Mercado La Nueva Viga (Mexico City) 35% and the Portland Fish Exchange (Portland, Maine) 32%. Collapse magnitude varied from 11% to 79% of the 5-year average price. Average collapse duration ranged from 13 to 24 weeks with some commodities (4%-22%) remaining collapsed at the end of 2020. For markets where volume data were available, collapses were also noted (59% of commodities in Toyosu, 10% in Mercamadrid and 19% in Portland Fish Exchange); in these cases, the volume collapse was more severe than the related price collapse. To better detect, anticipate and respond to future shocks, we recommend that relevant government agencies conduct comprehensive economic reviews of the COVID-19 pandemic throughout the seafood supply chain, including the outcomes of emergency measures, short- and long-term implications of market volatility and identify areas of supply and labour vulnerabilities.This article presents the immense impact that pandemics can have specifically on consumers' mental well-being, extending many of the well-being topics examined in this special issue on pandemics and consumer well-being. Avenues for future research in the area are suggested, with expanded discussion and future research suggestions related to four consumer characteristics including three areas associated with negative mental well-being (parenthood, suffering with chronic illness, aging, and family) as well as another characteristic associated with positive mental well-being (religion). The article concludes with a pressing call to action for academics and others to step up to the purpose in their careers and make a difference in the world for good in relation to consumers' mental well-being.This article advances the riveting discussion on how this special issue contributes to the consumer well-being literature. Specifically, this article endeavors to present an eclectic account of how the pandemics has had a lasting impact on the consumer well-being, its provenance and future research priorities for academics and practice. First, it briefly discusses the origin and relevance of the evolving issue of consumer well-being during pandemics. Second, it presents several directions for future research and third, it offers key insights for policymakers. It includes multiple research priorities that present vastly contrasting manifestations of consumer well-being. This article argues that future research will need to examine the drivers of consumer well-being during pandemics, the mechanisms that underlie the influence of pandemics on consumer well-being and the boundary conditions that accentuate/mitigate the influence of pandemic-induced factors.The COVID-19 pandemic brought grave financial concerns for families in the United States as they attempted to navigate the multifaceted impacts of the pandemic. The present descriptive study examined Florida families' employment characteristics, credit card debt, savings characteristics, use of savings based on employment and income variables, and patterns of use of the first 2020 economic impact payment during the early stages of the COVID-19 pandemic. Responses to an online questionnaire were collected from 526 Florida residents, age 18 or older, who were parents of minor children during the time the study was conducted. Findings are indicative of varying financial impacts on families based on gender, marital status, income level, and employment status related to COVID-19. Implications are presented for employers, educators, researchers, policymakers, and families.The impact of the COVID-19 pandemic on the overall well-being of consumers is disastrous. However, there is limited understanding of how the COVID-19 situation affects consumer well-being and how subsistence consumers mitigate well-being concerns and unique stresses. Following an exploratory, qualitative approach, 39 in-depth semi-structured interviews with subsistence consumers were conducted in India and Bangladesh. Findings from the thematic analysis reveal that subsistence consumers experienced unique stresses and hardships during COVID-19, which are unforeseen transitory financial stress, psychosocial stress, and marketplace and consumption-related stresses. Drawing on the appraisal theory of stress, our analysis of the data identifies the co-existence of two emotion-focused coping strategies-religiosity and social support-that interplay to overcome their well-being concerns in the emerging countries of India and Bangladesh. https://www.selleckchem.com/products/ly3039478.html Therefore, it may be of particular interest to managers and policymakers who seek to address the severe consequences of the COVID-19 pandemic on socio-economically subsistence consumers.The Coronavirus (COVID-19) pandemic reduced real and perceived access to healthcare services, exacerbating pandemic fear, and thus influencing consumers' adoption of preventative health behaviors. Extending the EHBM, results from two studies show that perceived access to health services and pandemic fear impact an individual's general and COVID-preventative health behaviors. High perceived access reduces pandemic fear through its buffering effects on perceived health vulnerability and pandemic-related health system concern, especially with telehealth usage during the pandemic. While pandemic fear motivates COVID-19 vaccination, pandemic fear reduces personal preventative health behavior (e.g., healthy eating, exercising) and has little effect on personal COVID-preventative behaviors (e.g., wearing a mask, social distancing) when individuals perceive high pandemic-related control. Moreover, the fear-behavior link does not hold for preventative health visits; instead, perceived access directly promotes preventative visits and screening. This research informs public health stakeholders' communication, education, and resource allocation during health crises like the COVID-19 pandemic.The COVID-19 pandemic has fundamentally changed the world and inevitably influenced people's behaviors including the likelihood of crime and deviance. Emerging empirical evidence suggests a decline in certain crimes (e.g., theft, robbery, and assault) but also proliferation of different violent behaviors and cybercriminal activity during the pandemic. To explain those trends, we draw on existent theories and elaborate on how crime and violence have been affected by the changes in people's daily routines and accumulated stressful conditions. However, as recent crime trends appear to be largely inconsistent and vary across social groups and contexts, we argue that social scientists need to pay particular attention to the differential experiences related to crime and violence during this global crisis. Specifically, because of the disproportionate experience of violence by vulnerable groups including minorities and women as well as the unique cross-national variations in deviance, more nuanced approaches to understanding causes of crime are warranted. We also discuss the limitations of present research and provide recommendations for the development of comparative and multi-disciplinary studies on criminal and deviant behaviors that are influenced by human crisis situations.As the COVID-19 pandemic turns two how should those who feel like we have been responsible neighbors (kept our distance, worn our masks, availed ourselves to the vaccine) respond to those we feel have not been-and specifically toward those who have refused the vaccine as a sign of political loyalty? How might those of us tempted to react from anger cultivate an alternative response? This paper explores the texts of two religions traditions-Mahāyāna Buddhism's Bodhicaryāvatāra and Christianity's Gospel of John-searching for resources for a response other than anger and blame.

10/02/2024


In a world where visual imagery holds immense power, the representation of the divine through captivating high-definition images has become a medium of expression and reverence. The beauty and intricacy of these images allow us to connect with the spiritual realm, engaging our senses and igniting our imagination. Whether it is the serene visage of a deity, the grandeur of sacred landscapes, or the intricate details of religious symbols, high-definition images create a vibrant portal to the divine.



As we explore the realm of God images in HD, we enter a space where art meets spirituality. These images, rich in color and detail, invite individuals to reflect, meditate, and find inspiration in the sacred. Each image tells a story, offers a glimpse into a higher reality, and serves as a testament to the diverse expressions of faith across cultures. Join us on this journey to discover a collection of divine visions that captivate the heart and soul, reminding us of the beauty that lies in our spiritual beliefs.

Symbolism of Sacred Imagery

Sacred imagery serves as a powerful conduit to the divine, encapsulating profound spiritual truths and traditions. These images are not merely representations; they are imbued with the essence of the beliefs they symbolize. Each detail, from colors to postures, carries meaning that transcends the physical form, inviting viewers to engage in contemplation and connection with a higher power.

The use of color in sacred imagery often reflects specific attributes of the divine. For instance, gold frequently symbolizes divinity and glory, while blue can represent peace and tranquility. The choice of imagery, whether it be a deity, angel, or celestial scene, also plays a significant role, as each figure embodies particular ideals and aspects of faith. By studying these elements, one can uncover a deeper understanding of the beliefs and values central to the spiritual tradition.



Additionally, sacred imagery invites community formation and shared experiences of faith. When congregants gather around images of the divine, it fosters a sense of unity and collective worship. The images serve as focal points, enhancing rituals and guiding prayers. In this way, sacred imagery acts not only as a personal connection to the divine but also as a collective bond among believers, creating a tapestry of faith that transcends individual experiences.

Impact of HD Technology on Religious Art

The advent of HD technology has transformed the way religious art is created, appreciated, and disseminated. Artists now have the ability to produce works with unparalleled clarity and detail, allowing viewers to engage with the sacred images in a more profound way. The vivid colors and intricate textures that HD technology affords breathe new life into traditional depictions of deities and religious scenes, enhancing their visual appeal and emotional resonance.

Moreover, the accessibility of HD images through digital platforms has expanded the reach of religious art beyond geographical boundaries. Individuals from diverse backgrounds can explore and share high-definition representations of sacred images, fostering a global appreciation for different artistic interpretations of the divine. This widespread availability not only promotes cultural exchange but also encourages a deeper understanding of the spiritual significance embedded within these sacred artworks.



Finally, HD technology has enabled innovative approaches to showcasing religious art, such as virtual reality installations and interactive displays. These advancements allow viewers to immerse themselves in sacred spaces, experiencing the art in a manner that transcends traditional viewing. https://www.god-images.in/category/god-lakshmi-devi-images can deepen spiritual reflections and personal connections to the divine, reshaping the landscape of how faith and art coexist in contemporary society.

Exploring Different Depictions of the Divine

The representation of the divine varies significantly across cultures and religions, showcasing the diverse interpretations of God. In Christianity, images of Jesus Christ are prevalent, often depicted in intimate and compassionate moments, emphasizing his role as savior and healer. These images foster a personal connection to the divine, inviting believers to reflect on their faith and the teachings of Christ. The use of light and color in these portrayals often enhances the emotional impact, creating a sense of sacredness that is visually captivating.

In Hinduism, the myriad deities present a rich tapestry of divine images that reflect the complexity of spiritual beliefs. From the playful Krishna to the fierce Durga, each representation serves to communicate unique attributes and stories that resonate with followers. The vibrancy and detail in these images are not merely for aesthetic pleasure; they serve as a means of connecting with the divine, allowing worshippers to engage with these figures during rituals and prayers. https://www.god-images.in/category/god-images involved in creating such depictions highlights the importance of visual representation in understanding and experiencing the sacred.

In Buddhism, the depictions of the Buddha emphasize serenity and enlightenment, often presented in calm postures that embody peace and mindfulness. https://www.god-images.in/category/god-ganesh-images serve as a reminder of the path to liberation and encourage practitioners to contemplate their inner nature. The focus on simplicity and tranquility in Buddhist art is designed to inspire a sense of calm and reflection, inviting viewers to engage with deeper spiritual truths. These varied artistic expressions illustrate the profound relationship between faith and visualization, connecting believers with the divine across different traditions.




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10/02/2024


In a world filled with diverse beliefs and spirituality, the imagery associated with the divine holds a special place in many hearts. https://www.god-images.in/category/god-images'>https://www.god-images.in/category/god-images of God evoke emotions that transcends the ordinary, inviting us to reflect on our faith and our connection to the universe. These vivid representations often serve as a source of inspiration, allowing individuals to visualize the essence of the divine in ways that are both profound and uplifting.

Exploring God images in high definition can be a transformative experience. With every intricate detail captured, these images offer a glimpse into the majesty and mystery that surrounds the concept of the divine. Whether it's the serene expressions of deities, the vibrant colors that symbolize various religious traditions, or the breathtaking natural landscapes that are infused with spiritual significance, these visuals help deepen our understanding and appreciation of the sacred. As we journey through these celestial visions, we open ourselves to the beauty and wonder that reflects our own spiritual paths.

The Art of Divine Imagery

The representation of divine figures has been a fundamental aspect of various cultures throughout history. These images serve not only as expressions of faith but also as powerful artistic creations that encapsulate the spiritual essence of the subjects they depict. From the intricate frescoes of the Renaissance to contemporary digital art, the portrayal of divine beings has evolved, showcasing the creativity and dedication of artists who strive to convey a sense of the sacred.

In today's digital age, the availability of high-definition images has transformed the way we engage with these representations. https://www.god-images.in/category/god-ganesh-images'>https://www.god-images.in/category/god-ganesh-images allow for a richer and more immersive experience, drawing viewers into the vibrant colors and intricate details that traditional media might not fully capture. This technological advancement invites a deeper appreciation for the artistry and spirituality embodied in these works, bridging the gap between the observer and the divine.



Moreover, the accessibility of divine imagery in high definition fosters a wider dialogue about spirituality and artistry. https://www.god-images.in/category/god-krishna-images'>https://www.god-images.in/category/god-krishna-images can explore various interpretations and styles from different cultures and time periods, creating a mosaic of beliefs and artistic expressions. This conversation encourages reflection on the nature of the divine and how it is represented, making divine imagery a timeless and ever-evolving aspect of human culture.

Symbolism in God Representations

God images often serve as powerful symbols that convey complex ideas about divinity, morality, and existence. Artists throughout history have used various forms of representation to express the nature of God, reflecting cultural beliefs and societal values. Symbolism can be found in the colors, shapes, and settings chosen, each carrying its own significance. For instance, gold is frequently used to symbolize divinity and purity, while light often represents knowledge and enlightenment.

In many traditions, specific attributes and symbolism associated with God images serve to remind believers of the divine qualities they aspire to emulate. In Christianity, the image of Jesus on the cross symbolizes sacrifice and redemption, reinforcing themes of love and forgiveness. Similarly, in Hinduism, deities like Krishna and Saraswati are depicted with distinct attributes such as flutes or books, representing their divine roles in fostering love and knowledge. https://www.god-images.in/ help followers connect with the divine on a more personal level.

Furthermore, the context in which God images are displayed plays a crucial role in their interpretation. Whether found in sacred spaces, artwork, or everyday settings, these images become focal points for worship and reflection. https://www.god-images.in/category/god-lakshmi-devi-images evoke emotional responses and inspire a sense of the transcendent. The diversity in God representations across cultures highlights the universal quest for understanding the divine, illustrating that despite differences, the search for spirituality unites humanity.

Impact of HD Technology on Spiritual Art

The advent of HD technology has significantly transformed the way spiritual art is created and experienced. Artists now have access to advanced tools that allow for more vivid colors, intricate details, and lifelike representations. This increased fidelity in the imagery elevates the viewer's experience, making the divine more accessible and relatable. As a result, spiritual artworks can evoke deeper emotional responses, allowing individuals to connect with the essence of the divine in a more profound manner.

Moreover, HD images of spiritual themes can bridge cultural and generational gaps. With the ability to reproduce these images with stunning clarity, diverse audiences can appreciate the nuances of various spiritual expressions. This inclusivity fosters a greater understanding of different beliefs and practices, encouraging dialogue and exploration among individuals from various backgrounds. As HD technology continues to evolve, it becomes a powerful medium for sharing and celebrating spirituality across the globe.



Finally, the proliferation of HD images on digital platforms has made spiritual art widely available, reaching audiences far beyond traditional gallery spaces. Social media and online galleries enable artists to share their work with a global audience, allowing for a collective appreciation of spiritual imagery. This accessibility not only democratizes art but also invites everyone to participate in the spiritual dialogue, encouraging personal reflection and shared inspiration. The impact of HD technology on spiritual art is not merely technical; it fosters connections that transcend borders and unite seekers on their spiritual journeys.






Explore a divine collection of God images in HD quality. Find solace and inspiration in our extensive gallery featuring all God images from various faiths and beliefs. Dive into the spiritual realm with our vast selection of God images HD , perfect for meditation, prayer, or simply admiring the beauty of divine artistry.

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