The bHLH transcription factor, PPLS1, interacts with SiMYB85 to control the color of pulvinus and leaf sheath by regulating anthocyanin biosynthesis in foxtail millet (Setaria italica). Foxtail millet (Setaria italica), a self-pollinated crop with numerous small florets, is difficult for cross-pollination. The color of pulvinus and leaf sheath with purple being dominant to green is an indicative character and often used for screening authentic hybrids in foxtail millet crossing. Deciphering molecular mechanism controlling this trait would greatly facilitate genetic improvement of cultivars in foxtail millet. Here, using the F2 bulk specific-locus amplified fragment sequencing approach, we mapped the putative causal gene for the purple color of pulvinus and leaf sheath (PPLS) trait to a 100 Kb region on chromosome 7. Expression analyses of the 15 genes in this region revealed that Seita.7G195400 (renamed here as PPLS1) was differentially expressed between purple and green cultivars. PPLS1 encodes a bHLH transcription factor and is localized in the nucleus with a transactivation activity. Furthermore, we observed that expression of a MYB transcription factor gene, SiMYB85 (Seita.4G086300) involved in anthocyanin biosynthesis, shows a totally positive association with that of PPLS1. Heterologous co-expression of both PPLS1 and SiMYB85 in tobacco leaves led to elevated anthocyanin accumulation and expression of some anthocyanin-related genes. Furthermore, PPLS1 physically interacts with SiMYB85. Taken together, our results suggest that PPLS1 interacts with SiMYB85 to control the color of pulvinus and leaf sheath by regulating anthocyanin biosynthesis in foxtail millet.The focus of the German National Cohort, the largest population-based cohort study in Germany to date, is the investigation of the most important widespread diseases, such as cardiovascular diseases, diabetes, cancer, neurological and psychiatric disorders, and frequent respiratory and infectious diseases. This cohort will answer questions on the development of these diseases and on the impact of genetic, environmental and lifestyle-related risk factors. Another focus is on the identification of early, subclinical markers of emerging diseases. To answer these questions, a comprehensive assessment of these health outcomes as well as of all potential determinants and precursors is mandatory.This paper describes the various health outcomes that are assessed in the German National Cohort, as well as the examination modules that are applied for deep phenotyping of study participants. Repeated collection of biosamples as well as functional measurements and application of modern imaging techniques at various time points allow for assessing the dynamics of physiological changes related to the individuals' health status. The prognostic value of these changes for disease development will be explored and translated to novel approaches for prevention and personalised medicine. Incident diseases are being assessed through self-reports by study participants and through record linkage with data from health insurances and cancer registries. https://www.selleckchem.com/products/AM-1241.html Additional information about clinical diagnoses is obtained from the treating physicians to ensure the highest possible validity.BACKGROUND Data on self-reported cardiovascular and metabolic diseases are available for the first 100,000 participants of the population-based German National Cohort (GNC, NAKO Gesundheitsstudie). OBJECTIVES To describe assessment methods and the frequency of self-reported cardiovascular and metabolic diseases in the German National Cohort. MATERIALS AND METHODS Using a computer-based, standardized personal interview, 101,806 participants (20-75 years, 46% men) from 18 nationwide study centres were asked to use a predefined list to report medical conditions ever diagnosed by a physician, including cardiovascular or metabolic diseases. For the latter, we calculated sex-stratified relative frequencies and compared these with reference data. RESULTS With regard to cardiovascular diseases, 3.5% of men and 0.8% of women reported to have ever been diagnosed with a myocardial infarction, 4.8% and 1.5% with angina pectoris, 3.5% and 2.5% with heart failure, 10.1% and 10.4% with cardiac arrhythmia, 2.7% and 1.8% with claudicatio intermittens, and 34.6% and 27.0% with arterial hypertension. The frequencies of self-reported diagnosed metabolic diseases were 8.1% and 5.8% for diabetes mellitus, 28.6% and 24.5% for hyperlipidaemia, 7.9% and 2.4% for gout, and 10.1% and 34.3% for thyroid diseases. Observed disease frequencies were lower than reference data for Germany. CONCLUSIONS In the German National Cohort, self-reported cardiovascular and metabolic diseases diagnosed by a physician are assessed from all participants, therefore representing a data source for future cardio-metabolic research in this cohort.Sulfur mustard (SM) is a highly toxic war chemical that causes significant morbidity and mortality and lacks any effective therapy. Rats exposed to aerosolized CEES (2-chloroethyl ethyl sulfide; 10% in ethanol), an analog of SM, developed acute respiratory distress syndrome (ARDS), which is characterized by increased inflammation, hypoxemia and impaired gas exchange. We observed elevated levels of extracellular nucleic acids (eNA) in the bronchoalveolar lavage fluid (BALF) of CEES-exposed animals. eNA can induce inflammation, coagulation and barrier dysfunction. Treatment with hexadimethrine bromide (HDMBr; 10 mg/kg), an eNA neutralizing agent, 2 h post-exposure, reduced lung injury, inhibited disruption of alveolar-capillary barrier, improved blood oxygenation (PaO2/FiO2 ratio), thus reversing ARDS symptoms. HDMBr treatment also reduced lung inflammation in the CEES-exposed animals by decreasing IL-6, IL-1A, CXCL-1 and CCL-2 mRNA levels in lung tissues and HMGB1 protein in BALF. Furthermore, HDMBr treatment also reduced levels of lung tissue factor and plasminogen activator inhibitor-1 indicating reduction in clot formation and increased fibrinolysis. Fibrin was reduced in BALF of the HDMBr-treated animals. This was further confirmed by histology that revealed diminished airway fibrin, epithelial sloughing and hyaline membrane in the lungs of HDMBr-treated animals. HDMBr completely rescued the CEES-associated mortality 12 h post-exposure when the survival rate in CEES-only group was just 50%. Experimental eNA treatment of cells caused increased inflammation that was reversed by HDMBr. These results demonstrate a role of eNA in the pathogenesis of CEES/SM-induced injury and that its neutralization can serve as a potential therapeutic approach in treating SM toxicity.

CS2 Case Battles

A CS2 Case Battle is a mode of play that lets players play their favorite games with a twist. It is a contest where participants wager their cases and the value of the items they remove determines a winner.



This feature is only available on third-party websites and is popular among CS2 fans who are attracted by the chance to open cases in a competitive manner. It is also an excellent way to get to know new people.

What are CS2 Case Battle Sites?

Case battles in the CS2 (CSGO) are games of chance where players compete against one another to win unique items within the game. These events have become popular among gamers who want to experience the thrill of victory and competition. These events are also a fantastic opportunity to earn money and purchase new equipment at a discounted price. It is important to know that CS2 battles are considered to be gambling in some jurisdictions and may not be allowed.

To be a part of an CS2 case-fight, players must create or join an existing competition. Once a competition has been created, participants will buy and open cases at the same cost. The person whose cases have the highest value wins. Depending on the format, the winner can keep all the items or divide the prizes among the best performers.

Make sure to verify the reputation of the site and make sure it offers safe gameplay before you decide to join. Review TrustPilot's rating and read reviews from customers. If you see mostly negative feedback, it is recommended to choose a different platform. Additionally, you should always select a CS2 case-fighting site that allows you to withdraw and deposit skins in a matter of minutes. It's also an excellent idea to select a site with exciting promotions and bonus offers.

There are a variety of Cs2 battle websites that offer various types games. Some of them are free and some require payment to join. It is crucial to select a site with competitive game modes that match your preferences and capabilities. For instance, if you prefer playing with your others, you should choose a site that features private case-based battles.

If you're a CS2 case opening fanatic, then you should try out Hellcase. The website has a wide selection of cases, and also has a Provably Fair System that ensures fairness and transparency for all users. It is among the most respected CS2 case-fighting sites and has an excellent support team. This is why CS2 players love it.

Hellcase

Case battles are not new to the CS:GO community. These fun, easy-to-play games pit players against each other for the chance to win expensive weapon skins. The popularity of this type of game has led to the creation of numerous websites for CS:GO battles that allow players to battle for prized items. These sites aren't currently regulated because they deal primarily in virtual in-game skins instead of real money wagering. They have the operating history, commercial credibility and security credentials of an authentic service that is transparent to the gaming demographics.

Hellcase allows users to sign-up through Steam, Facebook or Google. They are then prompted to verify their accounts using the provided information to gain access to the entire site's capabilities. The verification process involves ID validation for registration, as well as security settings for accounts to guard private information. Furthermore, responsible gambling limits and self-assessments ensure players have control over their bets.

After logging in, users can choose from a range of cases and participate in the games. You can also pick from a range of game options such as a 1v1 battle in which each player opens identical cases, and the winner will be determined by the highest value unboxed. Users can also create a 1v2 battle and compete against two opponents to provide an even more challenging experience.

Hellcase is not only an online competition site It also has many interesting features. For example, it allows players to use their War Tags to unlock exclusive cases and take part in Gleam giveaways. The site's social channels and event feed keep it entertaining with leaderboards and contests.

Hellcase also provides an opportunity for its players to upgrade their weapons with the trade-up contract. This feature lets players trade lower-quality skins for more valuable ones with a little luck. This system is unique in that it allows users to determine the likelihood of successfully upgrading a skin prior to making the trade.

KeyDrop

KeyDrop is a well-known case opening site well known for its user-friendly interface and large range of cases. KeyDrop is also well-known for its high-quality odds and system of incentives. In addition to offering a variety in deposit and withdrawal methods, KeyDrop also hosts regular promotions and giveaways for free. These features help users maximize their experience on the site.

The site offers several game modes that offer players the chance to win CS2 items. There are also team-based matches as well as one-on-one matches. The aim of these games is to open the cases and collect the most valuable skins. Players can also add extra cases to their contest which boosts the value of the prize. The best part is that participants can take part in any battle they wish, making it possible to earn a substantial amount of money in the event that they win.

To participate in a case battle the player must first organize or join an existing match. A match is a competition between two players or teams and each participant opens a case. The match is won by the person who has the most valuable skins. The amount of cases and costs may differ in different matches, so be sure you read the rules before joining.

https://squareblogs.net/ovalsalad3/five-case-battle-lessons-from-the-pros is five years old and has a proven track record. The security features on the site are also top-notch. The data of usage and payments are secured with encryption measures. The website uses proprietary provably fair technology to verify RNG results, which makes it impossible to alter the site. It also works with reputable CS:GO sponsors to help fund giveaways. This ensures that the odds are fair and fair to all players.

This site also has a community, where you can interact with other players and exchange your experiences. You can also meet others who share your preferences and can participate in tournaments. This way, you can make new friends and expand your social circle. You can even exchange your CS2 items for real-world cash.

Official CS2 Case Battle Sites

CS2 (CS:GO) case battle sites allow players to bet their cases against other users and compete for prizes. These sites are popular among CS2 users due to the fact that they offer more fun and engaging case opening experience. However, they're not without risk. Players must always play responsibly and make their decisions based on facts. They should also verify that the site is regulated and licensed by a trusted authority.

When deciding which case battle site to use it is essential to consider the variety and number of cases offered. A reputable cs2 case battle site will offer an extensive selection of cases and offer numerous rewards, including rare skins. It is also important to check the reputation of the site and customer feedback.

The first step in the first step of a CS2 or CSGO case-match is to log in using your Steam account. Select the type of contest that you want to enter and wait for others to sign up. Some sites charge a fee for entry that increases the stakes and also invests the players in the outcome. Once enough participants have participated and the winner is decided by evaluating the worth of the prizes won by each player.

After the battle, the winning player will receive all the cases and skins that the other players have dropped. This is an excellent way to win valuable CS2 items and increase your odds of unlocking that rare desert Eagle skin. Some CS2 case battle sites feature discovery tapes, which allow players to view other people's discoveries while opening their cases.

If you want an experience that is more traditional when opening a case, you may prefer to use the official CS2 method. It's safer and assures that all your cases are legitimate and safely stored in your inventory. If you want to add some excitement and challenge in the case opening process look into a website that has unique features. These websites can also help you save money on costly cases by letting you share them with other players. Moreover, they can offer an immersive gaming experience and are easier to use for novice players.

nt study can lead to improvements in this regard. ETHICAL CODE IR.TBZMED.REC.1398.100.Protein and DNA have been considered as the major components of chromatin. But beyond that, an increasing number of studies show that RNA occupies a large amount of chromatin and acts as a regulator of nuclear architecture. A significant fraction of long non-coding RNAs (lncRNAs) prefers to stay in the nucleus and cooperate with protein complexes to modulate epigenetic regulation, phase separation, compartment formation, and nuclear organization. An RNA strand also can invade into double-stranded DNA to form RNADNA hybrids (R-loops) in living cells, contributing to the regulation of gene expression and genomic instability. In this review, we discuss how nuclear lncRNAs orchestrate cellular processes through their interactions with proteins and DNA and summarize the recent genome-wide techniques to study the functions of lncRNAs by revealing their interactomes in vivo.BACKGROUND There is evidence that chronic stress negatively impacts parenting among refugees and other war-affected communities. Persistent parental stress and distress may lead to unresponsive, anxious, or overly harsh parenting and a corresponding increase in emotional and behavior problems among children. Most parenting interventions emphasize the acquisition of knowledge and skills; however, this overlooks the deleterious effects of chronic stress on parenting. The Caregiver Support Intervention (CSI) aims to strengthen quality of parenting skills by lowering stress and improving psychosocial wellbeing among refugee caregivers of children aged 3-12 years, while also increasing knowledge and skills related to positive parenting. The CSI is a nine-session psychosocial group intervention delivered by non-specialist providers. It is intended for all adult primary caregivers of children in high-adversity communities, rather than specifically targeting caregivers already showing signs of elevated distress. METH CSI as an effective intervention for strengthening parenting in families living in settings of high adversity, particularly refugee communities. https://www.selleckchem.com/products/bi-1347.html TRIAL REGISTRATION International Society for the Registration of Clinical Trials, ISRCTN22321773. Registered on 5 August 2019.After publication of our article [1], the database of IRON-CKD has undergone vigorous inspection - the authors have therefore re-examined database.Brain Derived Neurotrophic Factor (BDNF) signalling contributes to the formation, maturation and plasticity of Central Nervous System (CNS) synapses. Acute exposure of cultured brain circuits to BDNF leads to up-regulation of glutamatergic neuro-transmission, by the accurate tuning of pre and post synaptic features, leading to structural and functional synaptic changes. Chronic BDNF treatment has been comparatively less investigated, besides it may represent a therapeutic option to obtain rescue of post-injury alterations of synaptic networks. In this study, we used a paradigm of BDNF long-term (4 days) incubation to assess in hippocampal neurons in culture, the ability of such a treatment to alter synapses. By patch clamp recordings we describe the augmented function of excitatory neurotransmission and we further explore by live imaging the presynaptic changes brought about by long-term BDNF. In our study, exogenous long-term BDNF exposure of post-natal neurons did not affect inhibitory neurotransmission. We further compare, by genetic manipulations of cultured neurons and BDNF release, intracellular overexpression of this neurotrophin at the same developmental age. We describe for the first-time differences in synaptic modulation by BDNF with respect to exogenous or intracellular release paradigms. Such a finding holds the potential of influencing the design of future therapeutic strategies.BACKGROUND Psychotherapy is highly effective and widely acknowledged for treating various mental disorders. Nevertheless, in terms of methods for teaching effective psychotherapeutic approaches and competencies, there has been a lack of investigation. Training and supervision are the main strategies for teaching therapist competencies, and standardized role-plays with simulated patients (i.e., trained individuals playing someone with a mental disorder) seem useful for evaluating training approaches. In medical education, this procedure is now internationally established. However, so far, little use has been made of standardized role-playing to evaluate training and supervision in the area of clinical psychology and psychotherapy. METHODS In this study, standardized role-plays are used to evaluate methods for training and supervision. Central cognitive behavioral approaches for treating depression are taught in the training. The first experiment compares an active training approach (i.e., model learning) with a passive one (i.e., reading manual-based instructions). The second experiment compares a direct supervision technique (i.e., supervision based on video analysis) with an indirect one (i.e., supervision based on verbal reporting). In each experiment, 68 bachelor's and master's students of psychology will be randomly assigned to the experimental and control groups. Each student takes part in three role-plays (baseline, post and 3-month follow-up), which are all videotaped. Two independent raters assess therapist competencies in each role-play on the basis of a standardized competence scale. DISCUSSION The research project aims to contribute to the development of specific training and supervision methods in order to improve psychotherapy training and patient care. TRIAL REGISTRATION ISRCTN Registry, ISRCTN19173895. Registered on 10 December 2019.Following the publication of our article [1], the authors have notified us of a typo in the third bullet point of the Consensus Criteria section.It was highlighted that the original article [1] contained an error in the Quantitative evaluation of Methods. A bracket was misplaced in the formula. This Correction article shows the incorrect and correct formula.BACKGROUND Cardiovascular disease frequently causes morbidity and mortality in mucopolysaccharidoses (MPS); however, cardiovascular anatomy and dysfunction in MPS IVA (Morquio A disease) is not well described. Consequently, the study aimed to compare carotid artery structure and elasticity of MPS IVA patients with other MPS patients and healthy control subjects, and quantitate frequency of MPS IVA cardiac structural and functional abnormalities. METHODS Prospective, multi-center echocardiogram and carotid ultrasound evaluations of 12 Morquio A patients were compared with other MPS and healthy control subjects. Average differences between groups were adjusted for age, sex, and height with robust variance estimation for confidence intervals and P-values. RESULTS Morquio A patients demonstrated significantly higher (P  less then  0.001) adjusted carotid intima-media thickness (cIMT), mean (SD) of 0.56 mm (0.03) compared to control subjects, 0.44 mm (0.04). The Morquio A cohort had significantly greater adjusted carotid elasticity (carotid cross-sectional compliance + 43%, P  less then  0.

CS2 Case Battles

CS2 Case Battles are an exciting and enjoyable way to spice up your CSGO Experience. These competitions come in many different forms, including contests between participants and one-on-one challenges.

This unique gaming experience, available on websites not affiliated with Valve offers strategy and excitement in an enjoyable way. This article will assist you in understanding how it works and make the most of it.

They are a form of CS2 skin gambling

CS2 Case Battles are an exciting twist on CS:GO Case Opening that increases the excitement and stakes. These games can be played in specially-designed rooms on websites for opening cases and range from one-on-one battles to multiple-opponent challenges. Each participant opens a specific number of cases and the worth of the items they acquire is tallied to determine the winner. Based on https://writeablog.net/coachcondor5/10-tell-tale-symptoms-you-must-know-to-know-before-you-buy-cs2-case-battles of the website the winner could claim all of the items or share them with other top participants.

Case battles can be enjoyable and rewarding, no matter if you participate in a private or group match. However, they are a form of gambling, so you must check your local laws before participating in one. Also, make sure that the platform is licensed and controlled. A good way to check for this is to read the reviews on TrustPilot. You can be sure that you are using a secure and safe site.

Case battles are a simple affair players wager CS2 cases and the one who has the most valuable loot wins. The match is played in a separate room on the case-opening website and is able to be created by any user, or they can join a battle that has already been played. After all cases have been opened, winning skins are awarded to the winner.

It is essential to choose a CS2 Case Battle website that has a broad selection of cases, and also uses the system of dropping items that can be proved to be fair. Additionally, it's best to select the site that is backed by a well-established gaming company. This will ensure your money is secure and that you're not left in the dark regarding any possible issues.

CS2 case fights are an excellent way to increase the value of your CS2 items. Some CS2 players claim that case battles give the players 10 times more game-related items than they could earn through standard opening cases. KeyDrop and Hellcase are the most trusted websites for battles in case. Both provide a wide range of exciting and thrilling case battles.

They are a competitive event

The case battles on CS2 (CS:GO) are thrilling experiences that bring an extra level of excitement to your game. They can be anything from one-on-one matches to competing against multiple opponents. In these tournament-like games, players compete for open cases that are worth more than the opponents. They can also play in private rooms, where they compete against friends or other users. Hellcase provides a variety of thrilling CS2 (CS:GO) case battle modes that will bring a new dimension to the traditional game experience.

You create a battle room and buy the amount of boxes you would like to open. The battle begins with all participants opening their cases one by one. The player with the highest value unboxed is the winner. The winner receives all skins dropped by other players. This competition is not like opening cases at the Valve store, because it offers a risk-reward situation. The cases are costly however, they could yield valuable items.

Case battles can be a great alternative for opening cases on your own. They are also very thrilling, particularly if you win. They are not without risk, and you should only invest the amount you are able to lose. Remember that winning is largely dependent on luck. If you're not lucky enough, you could lose the majority of cases you open.

The legitimate websites that provide cases-fighting services have clear terms and conditions of services, participation rules, as well as details on the random selection process, and how the winnings are distributed. These websites provide a secure platform that protects your personal information and financial data. They also offer customer support to help you with any issues that you might face.



Case battles might not be as lucrative as individual battles, however they can be an enjoyable and competitive way to earn CS GO Skins. This unique gaming experience is only available on sites not affiliated with Valve. It is a combination of strategy, excitement, and the competitive spirit of CS2. These games can be even more fun than simply opening cases!

They require collaboration

CS2 case battles add a sense of competition to the conventional method of opening cases in CS2. The game's competition is exciting and creates suspense. It's an excellent way to increase the gaming experience. Although this unique gaming experience is not accessible on Valve's official website however, it is available on several third-party websites that provide buyers protection and secure transactions. This article will help you prepare for the next battle by explaining the rules of the game, its structure, and the format of CS2's case battles.

In contrast to other gambling games, cs2 battles require collaboration. This is because the performance of a team depends on the capabilities of each participant and not just their individual talents. A good CS2 Case Battle website will allow players to interact and share their experiences. This allows players to try various strategies and make educated choices. This will increase their chances of winning the war.

In a CS2 case battle, each participant pays an equal fee to join the event. After the required number is reached, the cases will be opened simultaneously. The winner is determined based on the total value of items revealed in each case. Once the winners are determined, prizes are distributed accordingly. This could include awarding all prizes to the winner or dividing them among the top participants.

CS2 battles are a great opportunity to develop your skills and learn new techniques from other players. They also allow you to observe how your opponents play the game, which can give you a better understanding of their strategies. It's similar to looking into their strategy manual. Moreover it is a CS2 case battle is a great chance to gain valuable skins for your favorite weapons. You can also find out which CS2 case has a high drop rate to boost your chances of winning. You can create an unique arsenal for your next matches by following this. Hell Case is a popular CSGO website that provides an array of exciting games and also opportunities to earn exclusive skins.

They are a type of training

Case battles for CS2 are a type of training for Counter-Strike 2 players. They can enjoy the excitement of playing against others and opening cases, while making valuable in-game items. CS2 battles are not as difficult to comprehend as they might appear once you've got a grasp of. CS2 case battles are an excellent way to get new products without spending any money.

Different csgo battle sites offer different battle modes. For instance, the renowned site CSGOLuck offers a variety of spirited 1v1 case battles that pit gamers against one another. CSGOLuck also uses fair algorithms to ensure equal chances to win for all players. This ensures that players have a trustworthy, transparent gaming environment that is free of fraudulent activity.

In order to participate in a case-battle, players first select the amount of cases they wish to open and then wait for their opponents to join. When the required number of players have joined the cases are opened simultaneously. The team or player who opens the most boxes with the most value wins the contest. The winnings are credited to the account of the winner. Some sites distribute the prizes to the top players, while other sites award the entire prize to one player or team.

Besides the excitement of competing against other players, csgo battle sites also offer various promotions and bonuses for their players. These can include welcome packages, tournaments, and other seasonal promotions. These bonuses can aid you in maximising the value of your battle experience and increase your chances of winning.

CS2 fights in case mode do more than just enhance the gameplay of CS2 they also promote teamwork, by creating an environment for gamers to talk and learn from one another. They're like training sessions for players and they can dramatically increase teamwork. Moreover, they provide a platform where players can look over their opponents discovery tapes, which is an exclusive feature that allows them to gain insights into their playing strategies. A combination of real-world experience and collaboration with teammates can help players prepare for fights in case, but it is important to remember that participating in these tournaments on third-party platforms can result in service fees.

To summarize, SNHG8 acted as an oncogene in ovarian carcinoma via targeting Wnt/β-catenin pathway, providing a new insight into understanding ovarian carcinoma at the molecular level.The Goddess of Health had two daughters, Panacea and Higinia, the fruit of the first is diagnosis, prognosis and treatment, and the fruit of the second is health management, prevention, and statistics. Humanbeings are unexpectedly subjected to1. Happenings they belong to the plane of the personality, crisis, the Age of the virus appears that had already been announced. The ideological support is not sustained, causing a bankruptcy in the system of our life. The subject acts unconsciously, does not believe in the advent of the catastrophe, does not follow logical rules, is unable to transcend, fear-anguish appears and this requires a lot of protection. Those who remain free from personal decomposition skewer him and put a project called "person" with his sense of life, his lifestyle and life project, which is the conjunction of body and spirit, which with the agony struggles against life itself.2. Events they belong to the plane of nature, catastrophes. The use of the word catastrophe is not synonymou swith unavoidable natural disaster, accident, although it is used by the health authorities this can have a great impact on those affected by the virus. This word has the final nuance of Greek tragedies. False arrogance appears, true madness. In the case of the Covid-19 there is something else, a dialectical position with oneself. They lived and we lived on a volcano. The example of the Apocalypse and its three plagues, epidemics and post-war neuroses, etc. The most striking neuropsychiatricsymptomatology is the appearance of "ageusia" and "anosmia", abruptly and totally, which disappears slowly, as well as sleep disturbances with ignagogic images post-traumatic stress charts appear.The COVID-19 pandemic has seriously disrupted the day-to-day running of hospitals, affecting the activity of all medical and surgical departments. It has also affected urology residents, depriving them of training at their usual workplaces and forcing them to support COVID units. This has implied not only the loss of daily activities, but also the uncertainty of job opportunities for the final year residents. In addition, the cancellation of numerous events such as congresses, exams,or courses has affected the annual planning of the specialty. A review of the current literature on the impact of the COVID-19 pandemic, as well as the de-escalation process, on resident training has been carried out using web search and PubMed. The situation of the residents has been analyzed, both through the information generated by recent literature and by the personal experience of the authors, from different areas evaluation systems, educational and surgical aspects, as well as healthcare work. As a result of this review, the negative impact of the crisison urology resident training can be observed, especially in the surgical field, but new learning opportunities or new forms of communication with the patient can also be observed. These educational and healthcare resources invite the urology resident in particular, and the medical society in general, to reinvent themselves. The aim of this article is to analyse the training of the urology resident in the de-escalation phase. Similarly, the emerging educational resources during the pandemic are synthesized, inviting the reader, and especially the urology resident, to continue their training and learningin these times of uncertainty.Objective SARS-CoV-2 pandemic hashigh repercussion on urologic minimally invasive surgery (MIS). https://www.selleckchem.com/products/z-vad(oh)-fmk.html Controversy about safety of MIS procedures during COVID-19 pandemic has been published. Nowadays, our priority should be create agreement in order to restart and organize MIS with safety conditions for patients and healthcare workers. METHODS Pubmed and web search was conducted with following terms "SARS-CoV-2", "COVID19", "COVID19 Urology", COVID19 Surgery", "COVID19 transmission", "SARS-CoV-2 transmission", "COVID19 nd minimally invasive surgery", "SARS-CoV-2 and CO 2insuflation". A narrative review of available literature and scientific evidence summary was done. A modify nominal group technique was used to achieve an expert consensus. First draft was circulated amongst authors. Definitive document was approved in May 26th. RESULTS Non evidence supports higher risk of SARSCoV-2 healthcare workers infection with MIS compared to open surgery. MIS is associated with shorter hospital stay than open surgery. Modify MIS indications to open surgery, with no scientific evidence, could spend valuable resources in detriment to COVID-19 patients. MIS indications should be prioritized attending to available resources and pandemic intensity. SARS-CoV-2screening 72 hours prior to surgery by clinical and epidemiological questionnaire and nasopharyngeal PCRis recommended, in order to prevent nosocomial transmission, professional infections and to minimize postoperative complications. Intraoperative steps should be established to reduce professional exposure to surgical aerosols, including surgical room reorganization, adequate personal protective equipment, surgical technique optimization and management of CO2 and surgical smoke. Conclusions In COVID-19 pandemic de-escalation, MIS carried out with optimal safety measurements, could contribute to reduce hospital resources utilization. With current evidence, MIS should not be limited or reconverted to open surgery during COVID-19 pandemic.Medical and surgical priorities have changed dramatically following the COVID-19 pandemic declaration. The rapid spread of the virus and the high number of cases has saturated the health system in our country and has forced many hospitals to redistribute resources to care for infected patients. This has led to asignificant reduction in surgical activity, in some cases reaching the point of delaying all elective interventions by performing only urgent interventions. The decrease in the number of infections with the progressive desaturation of hospitals has currently allowed us to enter a new phase of "de-escalation" or transition in order to recover our surgical activity in pediatric urology, which was practically canceled. It is proposed how surgical care activities such as outpatient care should be deal twith, in addition to the different circuits that patients must maintain and, above all, their and professional safety.