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12 mins ago


We examined drifting plant protection on 20 reservoirs around the globe's tropics and subtropics, utilizing > 30 year time-series of LANDSAT remote-sensing imagery. Despite decades of expensive grass control, floating intrusion extent is increasing. Drifting plant coverage correlates with growing metropolitan land address in catchments, implicating urban nutrient sources as plausible drivers. Floating vegetation invasions have undeniable societal expenses, but also supply advantages. Water hyacinths effortlessly absorb vitamins from eutrophic seas, mitigating nutrient pollution problems. When cleaned up on shores, plants may become compost, increasing soil fertility. The biomass is increasingly used as a renewable biofuel. We suggest a far more nuanced point of view on these invasions leaving futile eradication attempts towards an ecosystem management strategy that minimizes negative impacts while integrating possible personal and environmental benefits.In this contribution, we propose fishery driven predator release because the cause of the greatest grazing event ever noticed in the NE Atlantic. In line with the evolving understanding of limitations to populace connection, published and formerly unpublished information, we discuss whether overfishing caused a grazer bloom of the sea-urchin (Strongylocentrotus droebachiensis) causing overgrazing of more than 2000 km2 kelp (Laminaria hyperborea) forest along Norwegian and Russian coasts during the 1970 s. We reveal that seaside fisheries most likely exhausted predatory seaside seafood stocks through modernization of fishing methods and fleet. These fish were essential predators on urchins additionally the decrease coincided using the urchin bloom. From this circumstantial evidence, we hypothesize that coastal predatory fish had been important in managing sea urchins, and therefore an area population characteristics perspective is essential in management of coastal ecosystems.In this research, a simple yet effective https://cyclosporinainhibitor.com/sars-cov-2-mediated-endothelial-disorder-the-possibility-role-of-chronic-oxidative-strain/ , quick and easy plant-mediated green sol-gel auto-combustion process had been provided to synthesis magnesium-cobalt ferrite (MgCoFe2O4) nanocatalyst using an aqueous herb of apple skins as a chelating/combustion representative. The catalyst was assessed by multiple techniques, including FT-IR, XRD, FE-SEM, EDS, elemental mapping, TGA-DTA and VSM. Then, the catalytic potential associated with as-prepared MgCoFe2O4 nanocatalyst was analyzed when you look at the three-component condensation reaction of 1,3-dimethyl barbituric acid, aldehydes and malononitrile when it comes to one-pot synthesis of pyrano[2,3-d]pyrimidinedione and their particular bis-derivatives. The obtained results indicated the superb catalytic activity regarding the MgCoFe2O4 when you look at the three-component reaction. The large catalytic activity of the nanomaterials could be caused by the synergistic digital result between nanoparticles, which showcased the huge potential of multi-metallic nanomaterials within the catalysis field. Moreover, MgCoFe2O4 showed excellent magnetic properties, and it might be successfully divided and recovered by making use of an external magnetized for further reuses. To your most readily useful of our understanding, green synthesis of MgCoFe2O4 mediated by aqueous plant extract had been reported here the very first time, and also this work, therefore, can open up a brand new understanding in the course of design, green synthesis and application of exceptional green nanocatalyst for the lasting processes. MgCoFe2O4 as a magnetically recyclable heterogeneous catalyst, happens to be synthesized through plant-mediated process using an aqueous extract of apple skins.The intent behind the current research would be to figure out the diagnostic accuracy of vaginal urea and creatinine levels in the detection of early rupture of membrane (PROM). The Cochrane (central), EMBASE, PubMed, Scopus, and internet of Science were searched for researches posted through the beginning associated with databases as much as January 2020. We included published observational full-text articles. The mean variations (MD) and 95% self-confidence intervals (95% CI) were determined. The importance level was set as 0.05. Eleven studies (letter = 1324) were considered for meta-analysis. Using the bivariate design, the summary estimate of sensitiveness and specificity for urea ended up being 0.96 (95% CI 0.86, 0.98) and 0.93 (95% CI 0.83, 0.97), correspondingly. The summary estimate of susceptibility and specificity for creatinine was 0.98 (95% CI 0.92, 0.99) and 0.97 (95% CI 0.89, 0.99), respectively. The general suggest of urea and creatinine in case group had been considerably higher than that within the control team (MD = 12.63, 95%, CI [12.01, 13.25]) and (MD = 0.31, 95%, CI [0.29, 0.32]), correspondingly. The outcomes for this organized review showed that the suggest of urea and creatinine in the case group ended up being significantly more than that in the control team plus the susceptibility and specificity of creatinine is higher than urea into the analysis of PROM.Currently, chronic obstructive pulmonary illness (COPD) signifies the 4th cause of death all over the world with considerable economic burden. Comorbidities upsurge in number and severity with age and are also identified as essential determinants that influence the prognosis. In this observational study, we retrospectively analyzed information gathered from the RePoSI register. We aimed to analyze comorbidities and effects in a cohort of hospitalized elderly patients because of the clinical analysis of COPD. Socio-demographic, clinical faculties and laboratory findings were considered. The association between variables and in-hospital, 3-month and 1-year follow-up had been reviewed. Among 4696 in-patients, 932 (19.8%) had a diagnosis of COPD. Clients with COPD had more hospitalization, an important overt cognitive impairment, a clinically considerable disability and much more despair when comparing to non-COPD subjects.

55 mins ago


Battling dandruff and dry scalp can be a relentless challenge, sapping both your scalp's moisture and your confidence. Fortunately, an expertly assembled selection of the best 10 shampoos has emerged, promising not just relief but transformation for those afflicted. These shampoos aren't merely cleansing agents; they're specially formulated solutions aimed at tackling the root causes of dryness and flakiness, rejuvenating your scalp.

1. **HydraRich Scalp Nourishment Shampoo**: Topping the list, HydraRich isn't just about cleansing; it's about delivering deep moisturization with every wash. It's packed with natural oils and vitamins to not just eliminate dandruff, but to also leave your scalp feeling refreshed and nurtured.

2. **DermoCapillaire Flaky Scalp Managing Shampoo**: Next up, DermoCapillaire excels in gently removing dandruff while being exceptionally mild on your scalp. Perfect for those with sensitive skin, it focuses on the underlying issues without causing irritation.

3. **PureRelief Dandruff Defense Shampoo**: With its powerful dandruff-fighting formulation, PureRelief not only reduces flakes but also avoids their recurrence. It's loaded with botanical essences that cool and calm the scalp.

4. **MoistureBoost Hydrating Shampoo**: MoistureBoost goes beyond mere dandruff removal. It seeks to replenish the scalp's natural moisture balance, thanks to its hydrating ingredients that leave your hair feeling soft and supple.



5. **ClearPath Scalp Revival Shampoo**: Revive your scalp with ClearPath's unique blend of exfoliating and hydrating components. It's designed to remove buildup and restore natural shine to your hair.

6. **SootheSense Anti-Dandruff Shampoo**: For those seeking both scalp relief and dandruff control, SootheSense offers a soft yet potent solution. Its moisturizing agents combat dryness while calming irritation.

7. **BalancedBeauty Scalp Care Shampoo**: BalancedBeauty focuses on creating a balanced scalp environment with its pH-neutral formula. It clears away dandruff while protecting the scalp's natural oils.

8. **EssencePure Anti-Dandruff Shampoo**: EssencePure blends science and nature to offer an anti-dandruff shampoo that not only tackles flakes but also promotes overall scalp health with nourishing botanicals.

9. **HydraCleanse Scalp Therapy Shampoo**: This therapeutic shampoo takes a multi-faceted approach to scalp health, combing through every issue from dandruff to dryness. It's full of hydrating agents and soothing extracts that provide immediate comfort.

10. https://www.commonbeauty.net **PureThrive Intensive Moisture Shampoo**: Rounding off the list, PureThrive stands out for its intense moisturizing properties. Ideal for extremely dry scalp conditions, it brings back life and vibrancy to both scalp and hair.

Each shampoo on this list has been selected for its unique benefits in treating dry scalp and dandruff issues. While results can differ from person to person, these expert-recommended products are designed to offer significant relief and restore the balance and beauty of your hair.

1 hr ago


Many people fail to realize the significant role diet plays in hair health. Nutrition is not just vital for overall well-being but also critical for maintaining healthy hair and preventing hair loss. Here, we explore the essential foods that support hair health and those that might contribute to hair loss.

Nutrients like protein, vitamins, and minerals are the building blocks of healthy hair. https://www.commonbeauty.net Without adequate nutrition, your hair can become weak, brittle, and more prone to thinning. Protein, particularly, is essential as hair is primarily made up of a protein called keratin. Incorporating protein-rich foods into your diet, such as eggs, fish, lean meats, and beans, can support hair strength and growth.

Furthermore, a variety of vitamins and minerals are fundamental to hair strength and vitality. Vitamin A is essential for sebum production, helping to keep the scalp and hair hydrated. Look to sweet potatoes, spinach, and carrots for a healthy dose of vitamin A. B vitamins, especially biotin, have been associated with hair growth. Avocados, nuts, and eggs are excellent sources. For minerals, iron and zinc are vital; they’re found in foods like red meat, lentils, and pumpkin seeds. To complete the nutritional lineup, omega-3 fatty acids found in fish, walnuts, and chia seeds are important for hair health.

Meanwhile, some foods may indirectly lead to hair loss by affecting hormonal balance or nutrient absorption. High-mercury fish, sugary snacks, and refined carbs can have a detrimental effect on hair health. Steering clear of these and prioritizing a balanced diet filled with hair-health-promoting nutrients is advisable for those looking to improve their hair condition.

To sum up, acknowledging the profound impact of diet on hair health can empower individuals to make choices that promote hair growth and prevent hair loss. By integrating nutrient-rich foods into your diet and limiting harmful ones, you can support your hair's health from the inside out.



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Circles

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Videos

Sorry, no results were found.

Posts

12 mins ago


We examined drifting plant protection on 20 reservoirs around the globe's tropics and subtropics, utilizing > 30 year time-series of LANDSAT remote-sensing imagery. Despite decades of expensive grass control, floating intrusion extent is increasing. Drifting plant coverage correlates with growing metropolitan land address in catchments, implicating urban nutrient sources as plausible drivers. Floating vegetation invasions have undeniable societal expenses, but also supply advantages. Water hyacinths effortlessly absorb vitamins from eutrophic seas, mitigating nutrient pollution problems. When cleaned up on shores, plants may become compost, increasing soil fertility. The biomass is increasingly used as a renewable biofuel. We suggest a far more nuanced point of view on these invasions leaving futile eradication attempts towards an ecosystem management strategy that minimizes negative impacts while integrating possible personal and environmental benefits.In this contribution, we propose fishery driven predator release because the cause of the greatest grazing event ever noticed in the NE Atlantic. In line with the evolving understanding of limitations to populace connection, published and formerly unpublished information, we discuss whether overfishing caused a grazer bloom of the sea-urchin (Strongylocentrotus droebachiensis) causing overgrazing of more than 2000 km2 kelp (Laminaria hyperborea) forest along Norwegian and Russian coasts during the 1970 s. We reveal that seaside fisheries most likely exhausted predatory seaside seafood stocks through modernization of fishing methods and fleet. These fish were essential predators on urchins additionally the decrease coincided using the urchin bloom. From this circumstantial evidence, we hypothesize that coastal predatory fish had been important in managing sea urchins, and therefore an area population characteristics perspective is essential in management of coastal ecosystems.In this research, a simple yet effective https://cyclosporinainhibitor.com/sars-cov-2-mediated-endothelial-disorder-the-possibility-role-of-chronic-oxidative-strain/ , quick and easy plant-mediated green sol-gel auto-combustion process had been provided to synthesis magnesium-cobalt ferrite (MgCoFe2O4) nanocatalyst using an aqueous herb of apple skins as a chelating/combustion representative. The catalyst was assessed by multiple techniques, including FT-IR, XRD, FE-SEM, EDS, elemental mapping, TGA-DTA and VSM. Then, the catalytic potential associated with as-prepared MgCoFe2O4 nanocatalyst was analyzed when you look at the three-component condensation reaction of 1,3-dimethyl barbituric acid, aldehydes and malononitrile when it comes to one-pot synthesis of pyrano[2,3-d]pyrimidinedione and their particular bis-derivatives. The obtained results indicated the superb catalytic activity regarding the MgCoFe2O4 when you look at the three-component reaction. The large catalytic activity of the nanomaterials could be caused by the synergistic digital result between nanoparticles, which showcased the huge potential of multi-metallic nanomaterials within the catalysis field. Moreover, MgCoFe2O4 showed excellent magnetic properties, and it might be successfully divided and recovered by making use of an external magnetized for further reuses. To your most readily useful of our understanding, green synthesis of MgCoFe2O4 mediated by aqueous plant extract had been reported here the very first time, and also this work, therefore, can open up a brand new understanding in the course of design, green synthesis and application of exceptional green nanocatalyst for the lasting processes. MgCoFe2O4 as a magnetically recyclable heterogeneous catalyst, happens to be synthesized through plant-mediated process using an aqueous extract of apple skins.The intent behind the current research would be to figure out the diagnostic accuracy of vaginal urea and creatinine levels in the detection of early rupture of membrane (PROM). The Cochrane (central), EMBASE, PubMed, Scopus, and internet of Science were searched for researches posted through the beginning associated with databases as much as January 2020. We included published observational full-text articles. The mean variations (MD) and 95% self-confidence intervals (95% CI) were determined. The importance level was set as 0.05. Eleven studies (letter = 1324) were considered for meta-analysis. Using the bivariate design, the summary estimate of sensitiveness and specificity for urea ended up being 0.96 (95% CI 0.86, 0.98) and 0.93 (95% CI 0.83, 0.97), correspondingly. The summary estimate of susceptibility and specificity for creatinine was 0.98 (95% CI 0.92, 0.99) and 0.97 (95% CI 0.89, 0.99), respectively. The general suggest of urea and creatinine in case group had been considerably higher than that within the control team (MD = 12.63, 95%, CI [12.01, 13.25]) and (MD = 0.31, 95%, CI [0.29, 0.32]), correspondingly. The outcomes for this organized review showed that the suggest of urea and creatinine in the case group ended up being significantly more than that in the control team plus the susceptibility and specificity of creatinine is higher than urea into the analysis of PROM.Currently, chronic obstructive pulmonary illness (COPD) signifies the 4th cause of death all over the world with considerable economic burden. Comorbidities upsurge in number and severity with age and are also identified as essential determinants that influence the prognosis. In this observational study, we retrospectively analyzed information gathered from the RePoSI register. We aimed to analyze comorbidities and effects in a cohort of hospitalized elderly patients because of the clinical analysis of COPD. Socio-demographic, clinical faculties and laboratory findings were considered. The association between variables and in-hospital, 3-month and 1-year follow-up had been reviewed. Among 4696 in-patients, 932 (19.8%) had a diagnosis of COPD. Clients with COPD had more hospitalization, an important overt cognitive impairment, a clinically considerable disability and much more despair when comparing to non-COPD subjects.

55 mins ago


Battling dandruff and dry scalp can be a relentless challenge, sapping both your scalp's moisture and your confidence. Fortunately, an expertly assembled selection of the best 10 shampoos has emerged, promising not just relief but transformation for those afflicted. These shampoos aren't merely cleansing agents; they're specially formulated solutions aimed at tackling the root causes of dryness and flakiness, rejuvenating your scalp.

1. **HydraRich Scalp Nourishment Shampoo**: Topping the list, HydraRich isn't just about cleansing; it's about delivering deep moisturization with every wash. It's packed with natural oils and vitamins to not just eliminate dandruff, but to also leave your scalp feeling refreshed and nurtured.

2. **DermoCapillaire Flaky Scalp Managing Shampoo**: Next up, DermoCapillaire excels in gently removing dandruff while being exceptionally mild on your scalp. Perfect for those with sensitive skin, it focuses on the underlying issues without causing irritation.

3. **PureRelief Dandruff Defense Shampoo**: With its powerful dandruff-fighting formulation, PureRelief not only reduces flakes but also avoids their recurrence. It's loaded with botanical essences that cool and calm the scalp.

4. **MoistureBoost Hydrating Shampoo**: MoistureBoost goes beyond mere dandruff removal. It seeks to replenish the scalp's natural moisture balance, thanks to its hydrating ingredients that leave your hair feeling soft and supple.



5. **ClearPath Scalp Revival Shampoo**: Revive your scalp with ClearPath's unique blend of exfoliating and hydrating components. It's designed to remove buildup and restore natural shine to your hair.

6. **SootheSense Anti-Dandruff Shampoo**: For those seeking both scalp relief and dandruff control, SootheSense offers a soft yet potent solution. Its moisturizing agents combat dryness while calming irritation.

7. **BalancedBeauty Scalp Care Shampoo**: BalancedBeauty focuses on creating a balanced scalp environment with its pH-neutral formula. It clears away dandruff while protecting the scalp's natural oils.

8. **EssencePure Anti-Dandruff Shampoo**: EssencePure blends science and nature to offer an anti-dandruff shampoo that not only tackles flakes but also promotes overall scalp health with nourishing botanicals.

9. **HydraCleanse Scalp Therapy Shampoo**: This therapeutic shampoo takes a multi-faceted approach to scalp health, combing through every issue from dandruff to dryness. It's full of hydrating agents and soothing extracts that provide immediate comfort.

10. https://www.commonbeauty.net **PureThrive Intensive Moisture Shampoo**: Rounding off the list, PureThrive stands out for its intense moisturizing properties. Ideal for extremely dry scalp conditions, it brings back life and vibrancy to both scalp and hair.

Each shampoo on this list has been selected for its unique benefits in treating dry scalp and dandruff issues. While results can differ from person to person, these expert-recommended products are designed to offer significant relief and restore the balance and beauty of your hair.

1 hr ago


Many people fail to realize the significant role diet plays in hair health. Nutrition is not just vital for overall well-being but also critical for maintaining healthy hair and preventing hair loss. Here, we explore the essential foods that support hair health and those that might contribute to hair loss.

Nutrients like protein, vitamins, and minerals are the building blocks of healthy hair. https://www.commonbeauty.net Without adequate nutrition, your hair can become weak, brittle, and more prone to thinning. Protein, particularly, is essential as hair is primarily made up of a protein called keratin. Incorporating protein-rich foods into your diet, such as eggs, fish, lean meats, and beans, can support hair strength and growth.

Furthermore, a variety of vitamins and minerals are fundamental to hair strength and vitality. Vitamin A is essential for sebum production, helping to keep the scalp and hair hydrated. Look to sweet potatoes, spinach, and carrots for a healthy dose of vitamin A. B vitamins, especially biotin, have been associated with hair growth. Avocados, nuts, and eggs are excellent sources. For minerals, iron and zinc are vital; they’re found in foods like red meat, lentils, and pumpkin seeds. To complete the nutritional lineup, omega-3 fatty acids found in fish, walnuts, and chia seeds are important for hair health.

Meanwhile, some foods may indirectly lead to hair loss by affecting hormonal balance or nutrient absorption. High-mercury fish, sugary snacks, and refined carbs can have a detrimental effect on hair health. Steering clear of these and prioritizing a balanced diet filled with hair-health-promoting nutrients is advisable for those looking to improve their hair condition.

To sum up, acknowledging the profound impact of diet on hair health can empower individuals to make choices that promote hair growth and prevent hair loss. By integrating nutrient-rich foods into your diet and limiting harmful ones, you can support your hair's health from the inside out.



1 hr ago


Achieving a vibrant look isn't just a priority for women; men are increasingly seeking methods to fight against the signs of aging and preserve their vibrant appearance. Here are the top 10 vital anti-aging secrets geared towards men who wish to seem forever young.

1. Sun Protection is Key: Don't forget the importance of applying sunscreen daily, with at least SPF 30, to shield your skin from harmful UV rays which can speed up aging.

2. Moisturize Regularly: An effective moisturizer doesn't just keep your skin moist, but also reduces the look of fine lines and wrinkles. Choose for products tailored for men’s skin, which often be thicker and oilier than women’s.

3. Exfoliate Weekly: Removing dead skin cells by exfoliating once or twice a week helps to promote cell regeneration and reveal newer skin.

4. Nutritious Eating: A diet rich in antioxidants, vitamins, and minerals supports the skin's well-being and combats off indications of aging. Include lots of fresh produce into your meals.

5. Stay Hydrated: Maintaining ample quantities of water not only helps overall health but also keeps the skin hydrated and less prone to wrinkling.

6. Stop Smoking: Smoking drastically trigger the aging progression, leading to premature wrinkles and a lifeless complexion.

7. https://www.commonbeauty.net Reduce Alcohol Intake: Alcohol is known to dry out the skin and increase the likelihood of inflammation, contributing to the formation of aging symptoms.



8. Sleep Well: Adequate rest is key for skin regeneration, as sleep deprivation can lead to dark circles and a tired appearance.

9. Maintain a Fitness Routine: Keeping physically active boosts circulation and leads to a healthier complexion by delivering oxygen and nutrients to your skin.

10. Choose the Right Skincare Products: Invest in high-quality skincare products designed for aging skin. Seek out ingredients like retinol, hyaluronic acid, and peptides that effectively target signs of aging.

Following these 10 strategies can significantly aid in maintaining a youthful and healthful appearance. It’s never too too late to start taking care of your skin, and investing time and effort now can provide dividends in the years to come.

1 hr ago


Next, they expressed enthusiasm for group-based learning opportunities, such as cooking classes and support groups with similar SES peers. Finally, they suggested healthy food access resources.

Participant suggestions should be incorporated into intervention development. Ultimately, these interventional strategies should be tested and refined to help improve health for individuals with type 2 diabetes.
Participant suggestions should be incorporated into intervention development. Ultimately, these interventional strategies should be tested and refined to help improve health for individuals with type 2 diabetes.It is the position of the Association of Diabetes Care & Education Specialists that diabetes care and education specialists should play a central role in establishing and maintaining technology-enabled care in a variety of practice settings to optimize outcomes for people with diabetes and cardiometabolic conditions. The objectives of this position statement are to outline the role of diabetes care and education specialists as leaders in technology integration and to describe the resources and guidance the Association has developed to facilitate success in this role.
The primary aim of this pilot study was to examine the feasibility of codelivering a mental health intervention with an evidence-based type 2 diabetes (T2DM) boot camp care management program. The preliminary impact of participation on symptom scores for depression and anxiety and A1C was also examined.

This was a 12-week, non-randomized pilot intervention conducted with a convenience sample of adults with uncontrolled T2DM and moderate depression and/or anxiety at an urban teaching hospital. Co-management intervention delivery was via in-person and telehealth visits. Participants were assessed at baseline and 90 days.

Participants (n = 18) were African American, majority female (83%), and age 50.7 ± 13.4 years. Significant improvements in mental health outcomes were demonstrated, as measured by a reduction in Patient Health Questionnaire - 9 scores of 2.4 ± 2.9 (
= .01) and in Generalized Anxiety Disorder - 7 scores of 2.3 ± 1.9 (
= .001). The pre-post intervention mean A1C improved by 3.4 ± 2.1 units from 12% ± 1.4% to 8.5% ± 1.7% (
< .001).

The data generated in this pilot support the feasibility of delivering a diabetes and mental health co-management intervention using a combination of in-person and telemedicine visits to engage adults with T2DM and coexisting moderate depression and/or anxiety. Further research is warranted.
The data generated in this pilot support the feasibility of delivering a diabetes and mental health co-management intervention using a combination of in-person and telemedicine visits to engage adults with T2DM and coexisting moderate depression and/or anxiety. https://www.selleckchem.com/products/hydroxychloroquine-sulfate.html Further research is warranted.Hydroxyapatite (HA) coatings have been widely used to improve biocompatibility of metal alloys. This paper discusses the effect of hydroxyapatite (HA) and HA/alumina coated NiTi on their corrosion and dissolution behavior in Phosphate Buffer Saline (PBS) and Ringer's lactate solutions. The HA was synthesized from biogenic method and used as initial powder in High-Velocity Oxygen Fuel (HVOF) spray technique for the deposition of two coating types, fully HA and HA + 15 wt.% alumina composite coating. The as-synthesized HA had irregular porous structure with relatively low Ca/P ratio of 1.52. Tafel polarization curves obtained from electrochemical test had showed that both coatings increased the corrosion resistance of the NiTi substrates significantly. The ICP-MS analysis results that indicated a low nickel dissolved in both solutions after immersion in 21 days had supported these findings. The nickel levels in the solutions from all samples, either bared substrate or coated samples, in fact below the maximum limit for allergies of the human body. Immersion testing showed the stability of HA and HA/alumina layers as a barrier which maintains its morphology in PBS solution but slightly changed in Ringers.Abetalipoproteinemia (ABL) is a rare recessive condition caused by biallelic loss-of-function mutations in the MTTP gene encoding the microsomal triglyceride transfer protein large subunit. ABL is characterized by absence of apolipoprotein B-containing lipoproteins and deficiencies in fat-soluble vitamins leading to multisystem involvement of which neurological complications are the most serious. We present 3 siblings with ABL who were born to non-consanguineous parents of Filipino and Chinese background. Identical twin boys with long-standing failure to thrive and malabsorption were diagnosed at age 2 years. ABL therapy with vitamins and a specialized diet was initiated, replacing total parenteral nutrition at age 3 years. Their younger sister was diagnosed from a blood sample taken at birth; treatment was instituted shortly thereafter. We observed in the twins reversal and in their sister prevention of ABL systemic features following early implementation of fat restriction and high doses of oral fat-soluble vitamins. A targeted sequencing panel found that each affected sibling is homozygous for a novel MTTP intron 13 -2A>G splice acceptor site mutation, predicted to abolish splicing of intron 13. This variant brings to more than 60 the number of reported pathogenic mutations, which are summarized in this article. The twin boys and their sister are now doing well at 11 and 4 years of age, respectively. This experience underscores the importance of early initiation of targeted specialized dietary and fat-soluble vitamin replacements in ABL.Lung imaging and autopsy reports among COVID-19 patients show elevated lung scarring (fibrosis). Early data from COVID-19 patients as well as previous studies from severe acute respiratory syndrome, Middle East respiratory syndrome, and other respiratory disorders show that the extent of lung fibrosis is associated with a higher mortality, prolonged ventilator dependence, and poorer long-term health prognosis. Current treatments to halt or reverse lung fibrosis are limited; thus, the rapid development of effective antifibrotic therapies is a major global medical need that will continue far beyond the current COVID-19 pandemic. Reproducible fibrosis screening assays with high signal-to-noise ratios and disease-relevant readouts such as extracellular matrix (ECM) deposition (the hallmark of fibrosis) are integral to any antifibrotic therapeutic development. Therefore, we have established an automated high-throughput and high-content primary screening assay measuring transforming growth factor-β (TGFβ)-induced ECM deposition from primary human lung fibroblasts in a 384-well format.