Circles

Sorry, no results were found.

Posts

1 min ago


In today's digital age, where typing and texting have ended up being the norm, the significance of handwriting may seem to be diminishing. Handwriting is still an important skill for children to establish. Not just does it work as a way of interaction, however it likewise has various advantages for their overall advancement.

Handwriting practice is essential for kids as it assists them enhance their great motor abilities, hand-eye coordination, and mastery. It likewise plays a considerable function in cognitive advancement, imagination, and scholastic success. By motivating kids to practice handwriting regularly, moms and dads and teachers can help them develop self-confidence and enhance their creativity.



The Link Between Handwriting and Self-confidence


Handwriting can have a profound effect on a kid's self-esteem and self-confidence. When kids have the ability to compose legibly and with ease, they feel a sense of achievement and pride in their capabilities. This improves their confidence and encourages them to take on new obstacles.

https://notes.io/wXTH6 is a tangible representation of a kid's thoughts and ideas. When they see their words on paper, they feel a sense of ownership and recognition. This recognition helps them develop a positive self-image and belief in their capabilities.



How Handwriting Practice Can Improve Creativity


Handwriting practice not just improves fine motor skills however also has a positive influence on the brain's innovative procedures. Research study has actually revealed that when children compose by hand, it activates various locations of the brain compared to typing on a keyboard.

When kids compose by hand, they take part in a more deliberate and intentional process. This procedure stimulates the brain's neural paths related to imagination and analytical. It enables kids to believe more deeply and make connections between concepts, causing enhanced imagination.



The Advantages of Handwriting Practice for Kids with Learning Differences


Handwriting practice can be especially advantageous for children with discovering distinctions such as dyslexia, ADHD, and other discovering disabilities. These children typically battle with fine motor skills, attention period, and cognitive processing.

By participating in regular handwriting practice, these children can improve their great motor abilities and hand-eye coordination. This, in turn, can have a favorable effect on their total cognitive development and academic performance.



Tips for Producing a Favorable Handwriting Practice Environment


Creating a comfortable and supportive environment for handwriting practice is vital for children to develop self-confidence and imagination. Here are some ideas to create such an environment:

1. Supply the right tools: Make sure that children have access to appropriate writing tools such as pencils, pens, and paper that are comfortable to hold and utilize.

2. Set up a devoted area: Designate a particular area for handwriting practice that is devoid of distractions and has sufficient lighting.

3. Develop a routine: Set a routine time for handwriting practice every day to produce consistency and make it a habit.

4. Encourage relaxation: Teach children relaxation techniques such as deep breathing before starting handwriting practice to help them feel calm and focused.



The Function of Positive Reinforcement in Building Confidence and Creativity


Positive reinforcement plays a vital function in developing a child's self-confidence and enhancing their creativity during handwriting practice. When kids get praise and encouragement for their efforts, they feel encouraged to continue practicing and improving.

Moms and dads and educators can use favorable reinforcement methods such as spoken appreciation, benefits, and constructive feedback to increase a child's self-confidence. By concentrating on their strengths and progress instead of their errors, kids feel supported and empowered to take risks and explore their imagination.



Fun Handwriting Activities to Boost Self-confidence and Creativity


Making handwriting practice fun and enjoyable can even more enhance a child's confidence and imagination. Here are some creative and appealing activities to try:

1. Letter tracing: Offer worksheets or design templates with dotted lines for kids to trace letters. This assists them develop muscle memory and improve letter development.

2. Sensory writing: Usage different products such as sand, shaving cream, or finger paint for children to practice writing. This adds a tactile component to handwriting practice and makes it more appealing.

3. Storytelling and journaling: Motivate kids to compose stories or keep a journal. This allows them to reveal their creativity and develop their writing abilities in a meaningful method.



The Advantages of Including Handwriting Practice into Daily Routines


Making handwriting practice a part of a child's daily routine has many advantages. It assists them establish discipline, consistency, and a sense of obligation. Regular practice also strengthens the skills they have discovered and enables them to progress quicker.

Integrating handwriting practice into day-to-day activities can be as basic as having children compose grocery lists, thank-you notes, or everyday reflections. By integrating handwriting into their daily lives, children see its importance and importance, which further motivates them to improve.



How Handwriting Practice Can Improve Fine Motor Abilities


Handwriting practice is an excellent way to enhance great motor skills in children. The act of holding a pencil, managing its movement, and forming letters requires precise hand movements and coordination.

Regular handwriting practice helps children develop the small muscles in their hands and fingers, enhancing their mastery and control. This, in turn, improves their ability to perform jobs that need fine motor skills, such as connecting shoelaces, buttoning clothing, and using utensils.



The Function of Handwriting in Academic Success


Handwriting plays a considerable role in scholastic success, particularly in the early years of education. It is not only a means of communication but also a necessary tool for finding out and keeping details.

Research has actually revealed that when kids write by hand, they participate in a more active process that promotes much better memory retention and understanding. In addition, instructors often assess students' understanding and understanding through written tasks and examinations, making understandable handwriting vital for scholastic accomplishment.



Encouraging Self-confidence and Creativity Through Handwriting Practice


In conclusion, handwriting practice is a valuable ability for kids to develop, despite the digital age we live in. It has various advantages, including improving confidence, enhancing imagination, improving great motor skills, and contributing to academic success.

By developing a positive handwriting practice environment, using favorable reinforcement methods, and including fun activities into everyday routines, moms and dads and educators can assist children build self-confidence and release their creativity. Handwriting practice is not practically composing letters; it has to do with promoting a kid's total advancement and setting them up for success in various elements of life.

From Scribbles to Script: A Guide

notes.io

2 mins ago


BACKGROUND A meaningful and purpose-driven life is associated with better health outcomes. We test whether meaning in life is associated with risk of cognitive impairment using data from a large, multi-national study. METHODS Participants (N = 22,514) were from the Survey of Health, Ageing and Retirement in Europe (SHARE). Participants from 14 countries reported on their meaning in life. Cognitive impairment was derived from performance on cognitive tasks administered at baseline and at up to three follow-up waves (waves 2-6 assessed between 2010-2015). RESULTS Lack of meaning in life was associated with a more than 20 % increased risk of incident cognitive impairment over the up to 9-year follow-up (Hazard Ratio = 1.24; 95 % Confidence Interval = 1.17-1.31). Further, compared to participants who reported often feeling meaning in life, participants who reported never feeling meaning in life were at an approximately 75 % increased risk of impairment (Hazard Ratio = 1.75, 95 % Confidence Interval = 1.19-2.57). The association between meaning in life and risk of cognitive impairment was apparent across four regions of Europe (Northern, Southern, Eastern, Western) and in Israel and was not moderated by sociodemographic characteristics. CONCLUSIONS Reporting lower meaning in one's life is associated with risk of incident cognitive impairment. Meaning may be a potential target of intervention for healthier cognitive aging. Phosphorus (P) fertilizer is widely used to increase wheat yield. https://www.selleckchem.com/products/srt2104-gsk2245840.html However, it remains unclear whether prolonged intake of wheat grain that received long-term P application may promote human health risks by influencing heavy metal(loid)s (HMs) accumulation. A 10-year field experiment was conducted to evaluate the effects of continuous P application (0, 25, 50, 100, 200, and 400 kg P ha-1) on human health risks of HMs, including zinc (Zn), copper (Cu), cadmium (Cd), lead (Pb), arsenic (As), nickel (Ni), and chromium (Cr), by ingesting wheat grain. The results showed that P application facilitated Zn, Pb, Cd, and As accumulation in the topsoil. The Zn, Cu, Pb, and Ni concentrations in grain were decreased, while Cd and As were increased by P application. All HMs concentrations of both soil and grain were in the ranges of corresponding safety thresholds at different P levels. The accumulation abilities of Zn, Cu, Pb, and Ni from soil and straw to grain were suppressed by P addition while of As was enhanced. There was no significant difference in the hazard index (HI) of the investigated HMs in all treatments except 25 kg ha-1. The threshold cancer risk (TCR) associated with As and Cd was enhanced, while that of Pb was alleviated as P application increased. Behaviors of Cr from soil to wheat and to humans were not affected by P application. Phosphorus application at a rate of 50 kg ha-1 decreased total non-cancer and cancer risks by 15% and 21%, respectively, for both children and adults, compared to the highest value. In conclusion, long-term optimal application of 50 kg P ha-1 to wheat did not result in additional adverse effects on the total non-carcinogenic or carcinogenic risk caused by the studied HMs to humans through the ingestion of wheat grain. The trade-off between self-maintenance and reproduction has been explored wildly in reptiles. However, the effects of exogenous pollutants on the life history traits of reptiles have not been paid attention to. In the current study, lizards (Eremias argus), living in the soil polluted by perfluorooctanoic acid (PFOA) were selected as the main focus. Bodyweight, survival rate, clutch characteristics and biochemical analysis (immune response, lipid accumulation, sex steroid secretion, antioxidant level, and metabolomics) were investigated and the results revealed that lizards' life-history trade-offs are gender-dependent females were more inclined to choose a "Conservative" life-history strategy. After 60 days of exposure to PFOA, larger body weight, higher survival rate, stronger immune response, and lighter egg mass in females suggested that their trade-offs are more biased towards self-maintenance. Whereas, the "Risk" strategy would more popular among males reduced body weight and survival rate, and suffering from oxidative damage indicated that males made little investment in self-maintenance. Dibutyl phthalate (DBP) is widely used as plasticizer and has been detected in the environment, posing a threat to animal health. However, the effects of DBP on agricultural microbiomes are not known. In this study, DBP levels in black soil were evaluated, and the impact of DBP contamination on the uptake and metabolism of sugars in microbes was assessed by glucose absorption tests, metaproteomics, metabolomics, enzyme activity assays and computational simulation analysis. The results indicated that DBP contamination accelerated glucose consumption and upregulated the expression of porins and periplasmic monosaccharide ATP-binding cassette (ABC) transporter solute-binding proteins (SBPs). DBP and its metabolic intermediates (carboxymuconate and butanol) may form a stable complex with sugar transporters and enhance the rigidity and stability of these proteins. Sugar metabolism resulting in the generation of ATP and reducing agent (NADPH), as well as the expression of some key enzymes (dehydrogenases) were also upregulated by DBP treatment. Moreover, a diverse bacterial community appears to utilize sugar, suggesting that there are widespread effects of DBP contamination on soil microbial ecosystems. The results of this study provide a theoretical basis for investigating the toxicological effects of DBP on microbes in black soil. This work was conducted to study the effect of soil pH (4.0, 6.0, and 8.0) on the transport, fractionation, and oxidation of trivalent chromium [Cr(III)]. Variation in pH altered soil chemical and mineralogical properties such as zeta potential, cation exchange capacity and redox potential of natural soil. Breakthrough curves and batch sorption experiments coupled with fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) analyses demonstrated that the easy mobility of Cr(III) in pH 4.0 soil was dominated by the limited coordination effect. The high retention of Cr(III) in pH 8.0 soil was mainly ascribed to the hydrolysis. Incubation experiments indicated that the proportions of Cr in exchangeable fraction decreased with increasing of soil pH and incubation time, and kinetics analysis revealed that the time dependent transformation was controlled by mass transfer and chemical processes (e.g., hydrolysis, ion association). The XPS confirmed the oxidation of Cr(III) in pH 8.0 soil during the incubation period.

4 mins ago


Some patients with the novel 2019 coronavirus disease (COVID-19) display elevated liver enzymes. Some antiviral drugs that can be used against COVID-19 are associated with a risk of hepatotoxicity.

To analyze the clinical significance of the dynamic monitoring of the liver function of patients with COVID-19.

This was a retrospective study of patients diagnosed with COVID-19 in January and February 2020 at the Department of Infection, Shantou Central Hospital. The exclusion criteria for all patients were (1) History of chronic liver disease; (2) History of kidney disease; (3) History of coronary heart disease; (4) History of malignancy; or (5) History of diabetes. The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase, and total bilirubin of patients with COVID-19 were measured on days 1, 3, 7 and 14 after admission, and compared to non-COVID-19 patents.

Twelve patients with COVID-19 (seven men and five women) and twelve controls (eight men and four ction indicators are not obvious in the early stage of COVID-19, but clinically significant changes might be observed in severe COVID-19.
Tonsillectomy is the most common procedure for treatment of pediatric recurrent acute tonsillitis and tonsillar enlargement that contributes to obstructive sleep apnea hypopnea syndrome. Postoperative hemorrhage of tonsillectomy is a life-threatening complication.

To identify the risk factors that may contribute to primary and secondary post-operative hemorrhage in pediatric tonsillectomy.

The clinical data from 5015 children, 3443 males and 1572 females, aged 1.92-17.08 years, with recurrent tonsillitis and/or tonsil hypertrophy who underwent tonsillectomy in our hospital from January 2009 to December 2018 were retrospectively collected. The variables including sex, age, time of onset, diagnosis, method of tonsillectomy, experience of surgeon, time when the surgery started and monthly average air temperature were abstracted. The patients with postoperative hemorrhage were classified into two groups, the primary bleeding group and the secondary bleeding group, and their characteristics were compared with 0.038, respectively). There was no significant difference in sex, diagnosis, time when the surgery started or monthly average air temperature. There was a significant difference in the intervention measures between the primary bleeding group and the secondary bleeding group (

= 10.947,
= 0.001). The lower pole and middle portion were the common bleeding sites, followed by the upper pole and palatoglossal arch.

The incidence rate of post-tonsillectomy hemorrhage is low. Coblation tonsillectomy and less than 5 years' experience of surgeon contribute to the tendency for primary hemorrhage. Age and time of onset are responsible for secondary hemorrhage.
The incidence rate of post-tonsillectomy hemorrhage is low. Coblation tonsillectomy and less than 5 years' experience of surgeon contribute to the tendency for primary hemorrhage. Age and time of onset are responsible for secondary hemorrhage.
As transjugular intrahepatic portosystemic shunt (TIPS) creation alters the hemodynamic status of the portal system, whether reduced portal blood supply affects the synthetic reserve function of the liver has been the focus of clinical attention. Since the Viatorr stent entered the Chinese market in 2015, it has not yet been widely used in clinical practice. Further, unlike other countries, the main cause of liver cirrhosis in China is viral hepatitis. Therefore, use of the Viatorr stent to establish a TIPS channel in patients with liver cirrhosis with differing etiologies is of great clinical interest.

To investigate factors affecting changes in liver reserve function after TIPS Viatorr stent implantation.

Clinical data from 200 patients with cirrhotic portal hypertension who received TIPS treatment from March 2016 to March 2020 were analyzed retrospectively. The patients were divided into three groups (A-C), according to their disease etiology, with post-hepatitis, autoimmune, and alcoholic cirrhosis,for groups B (10.64 ± 1.90;
= -2.92;
= 0.004) and C (10.82 ± 2.01;
= -3.29;
= 0.001).

Insertion of 8 mm internal diameter Viatorr stent has no significant effects on liver reserve function. Changes of liver reserve function in the medium and long term may be related to the etiology and treatment of portal hypertension.
Insertion of 8 mm internal diameter Viatorr stent has no significant effects on liver reserve function. Changes of liver reserve function in the medium and long term may be related to the etiology and treatment of portal hypertension.
Radiotherapy or chemoradiotherapy is widely used for the treatment of rectal cancer preoperatively. https://www.selleckchem.com/pharmacological_epigenetics.html Although the combination of radiotherapy and chemotherapy as an established preoperative neoadjuvant therapy shows high efficacy in the treatment of rectal cancer, some patients experience a response of poor tolerance and outcomes due to the long duration radiotherapy. The study compared short duration radiotherapy plus chemotherapy
long duration radiotherapy plus chemotherapy for rectal cancer to determine whether short duration radiation treatment should be considered to diminish complications, reduce risk of recurrence and improve survival in patients with rectal cancer.

To evaluate the efficacy and safety of short duration radiotherapy combined with chemotherapy for the treatment of advanced rectal cancer.

One hundred patients with stage IIIB or higher severe rectal cancer were selected as the study subjects at The First Affiliated Hospital of Hebei North University between December 2018 and Decemb observation group and 10.0% in the control group, the distant metastasis rate was 6.0% in the observation group and 8.0% in the control group difference (all
< 0.05).

Short duration radiotherapy combined with chemotherapy can improve the cure rate, prolong the survival time and reduce the incidence of complications in patients with advanced rectal cancer.
Short duration radiotherapy combined with chemotherapy can improve the cure rate, prolong the survival time and reduce the incidence of complications in patients with advanced rectal cancer.

Videos

Some of you are worried that since the founder of Children’s Health Defense is slated to become a full-time Washington politician, we at CHD may begin to compromise some of our principles in order to support some watered-down policies. Because at least watered-down policies would be better than no policies, right?

But we are here to tell you, we will not compromise our principles. Ever.



Why?

Because CHD is now, and has always been, playing the “outside game.”

Support from people like YOU is what keeps CHD “totally free from conflicts of interest.". Become a supporting CHD member today: https://childrenshealthdefense.org/about-us/donate/

What is the general health of unvaccinated children compared to vaccinated ones?

Let the science speak.

Watch the full movie FREE: https://vaxxed3.org

Get your own DVD copy in case this film ever gets taken down: https://chdstore.org/category/49f3ff40-997a-ef11-a066-3cecef705787

When we started Children’s Health Defense (then called the World Mercury Project) 17 years ago, we didn’t foresee ourselves ever having to publicly ask this question in all seriousness:

How can we prevent our kids from getting cancer?

Here’s the response of radiologist/oncologist William Makis, M.D., who was kicked off Twitter during the COVID era — so you know he probably has something valuable to say.

Full interview: https://x.com/i/broadcasts/1jMJgBPnmrwGL

Circles

Sorry, no results were found.

Videos

Some of you are worried that since the founder of Children’s Health Defense is slated to become a full-time Washington politician, we at CHD may begin to compromise some of our principles in order to support some watered-down policies. Because at least watered-down policies would be better than no policies, right?

But we are here to tell you, we will not compromise our principles. Ever.



Why?

Because CHD is now, and has always been, playing the “outside game.”

Support from people like YOU is what keeps CHD “totally free from conflicts of interest.". Become a supporting CHD member today: https://childrenshealthdefense.org/about-us/donate/

What is the general health of unvaccinated children compared to vaccinated ones?

Let the science speak.

Watch the full movie FREE: https://vaxxed3.org

Get your own DVD copy in case this film ever gets taken down: https://chdstore.org/category/49f3ff40-997a-ef11-a066-3cecef705787

When we started Children’s Health Defense (then called the World Mercury Project) 17 years ago, we didn’t foresee ourselves ever having to publicly ask this question in all seriousness:

How can we prevent our kids from getting cancer?

Here’s the response of radiologist/oncologist William Makis, M.D., who was kicked off Twitter during the COVID era — so you know he probably has something valuable to say.

Full interview: https://x.com/i/broadcasts/1jMJgBPnmrwGL

Egg freezing. In-vitro fertilization. Polycystic ovarian syndrome.

Women in their 20s and early 30s who aren’t yet ready to have children are pursuing these options (and paying mighty sums, too), believing that they’ll become infertile “any day now.”

Nicole Shanahan tells Roseanne Barr that she was one of those women, and you’ll never expect the (literal) $100 million finding that led Nicole to eventually question everything the IVF clinics told her.

Have you had experience with egg freezing, IVF, or PCOS? Share!

Full video: https://www.youtube.com/watch?v=DZGt-kd2t94

The founder and chairman-on-leave of Children’s Health Defense is now in the West Wing.

Posts

1 min ago


In today's digital age, where typing and texting have ended up being the norm, the significance of handwriting may seem to be diminishing. Handwriting is still an important skill for children to establish. Not just does it work as a way of interaction, however it likewise has various advantages for their overall advancement.

Handwriting practice is essential for kids as it assists them enhance their great motor abilities, hand-eye coordination, and mastery. It likewise plays a considerable function in cognitive advancement, imagination, and scholastic success. By motivating kids to practice handwriting regularly, moms and dads and teachers can help them develop self-confidence and enhance their creativity.



The Link Between Handwriting and Self-confidence


Handwriting can have a profound effect on a kid's self-esteem and self-confidence. When kids have the ability to compose legibly and with ease, they feel a sense of achievement and pride in their capabilities. This improves their confidence and encourages them to take on new obstacles.

https://notes.io/wXTH6 is a tangible representation of a kid's thoughts and ideas. When they see their words on paper, they feel a sense of ownership and recognition. This recognition helps them develop a positive self-image and belief in their capabilities.



How Handwriting Practice Can Improve Creativity


Handwriting practice not just improves fine motor skills however also has a positive influence on the brain's innovative procedures. Research study has actually revealed that when children compose by hand, it activates various locations of the brain compared to typing on a keyboard.

When kids compose by hand, they take part in a more deliberate and intentional process. This procedure stimulates the brain's neural paths related to imagination and analytical. It enables kids to believe more deeply and make connections between concepts, causing enhanced imagination.



The Advantages of Handwriting Practice for Kids with Learning Differences


Handwriting practice can be especially advantageous for children with discovering distinctions such as dyslexia, ADHD, and other discovering disabilities. These children typically battle with fine motor skills, attention period, and cognitive processing.

By participating in regular handwriting practice, these children can improve their great motor abilities and hand-eye coordination. This, in turn, can have a favorable effect on their total cognitive development and academic performance.



Tips for Producing a Favorable Handwriting Practice Environment


Creating a comfortable and supportive environment for handwriting practice is vital for children to develop self-confidence and imagination. Here are some ideas to create such an environment:

1. Supply the right tools: Make sure that children have access to appropriate writing tools such as pencils, pens, and paper that are comfortable to hold and utilize.

2. Set up a devoted area: Designate a particular area for handwriting practice that is devoid of distractions and has sufficient lighting.

3. Develop a routine: Set a routine time for handwriting practice every day to produce consistency and make it a habit.

4. Encourage relaxation: Teach children relaxation techniques such as deep breathing before starting handwriting practice to help them feel calm and focused.



The Function of Positive Reinforcement in Building Confidence and Creativity


Positive reinforcement plays a vital function in developing a child's self-confidence and enhancing their creativity during handwriting practice. When kids get praise and encouragement for their efforts, they feel encouraged to continue practicing and improving.

Moms and dads and educators can use favorable reinforcement methods such as spoken appreciation, benefits, and constructive feedback to increase a child's self-confidence. By concentrating on their strengths and progress instead of their errors, kids feel supported and empowered to take risks and explore their imagination.



Fun Handwriting Activities to Boost Self-confidence and Creativity


Making handwriting practice fun and enjoyable can even more enhance a child's confidence and imagination. Here are some creative and appealing activities to try:

1. Letter tracing: Offer worksheets or design templates with dotted lines for kids to trace letters. This assists them develop muscle memory and improve letter development.

2. Sensory writing: Usage different products such as sand, shaving cream, or finger paint for children to practice writing. This adds a tactile component to handwriting practice and makes it more appealing.

3. Storytelling and journaling: Motivate kids to compose stories or keep a journal. This allows them to reveal their creativity and develop their writing abilities in a meaningful method.



The Advantages of Including Handwriting Practice into Daily Routines


Making handwriting practice a part of a child's daily routine has many advantages. It assists them establish discipline, consistency, and a sense of obligation. Regular practice also strengthens the skills they have discovered and enables them to progress quicker.

Integrating handwriting practice into day-to-day activities can be as basic as having children compose grocery lists, thank-you notes, or everyday reflections. By integrating handwriting into their daily lives, children see its importance and importance, which further motivates them to improve.



How Handwriting Practice Can Improve Fine Motor Abilities


Handwriting practice is an excellent way to enhance great motor skills in children. The act of holding a pencil, managing its movement, and forming letters requires precise hand movements and coordination.

Regular handwriting practice helps children develop the small muscles in their hands and fingers, enhancing their mastery and control. This, in turn, improves their ability to perform jobs that need fine motor skills, such as connecting shoelaces, buttoning clothing, and using utensils.



The Function of Handwriting in Academic Success


Handwriting plays a considerable role in scholastic success, particularly in the early years of education. It is not only a means of communication but also a necessary tool for finding out and keeping details.

Research has actually revealed that when kids write by hand, they participate in a more active process that promotes much better memory retention and understanding. In addition, instructors often assess students' understanding and understanding through written tasks and examinations, making understandable handwriting vital for scholastic accomplishment.



Encouraging Self-confidence and Creativity Through Handwriting Practice


In conclusion, handwriting practice is a valuable ability for kids to develop, despite the digital age we live in. It has various advantages, including improving confidence, enhancing imagination, improving great motor skills, and contributing to academic success.

By developing a positive handwriting practice environment, using favorable reinforcement methods, and including fun activities into everyday routines, moms and dads and educators can assist children build self-confidence and release their creativity. Handwriting practice is not practically composing letters; it has to do with promoting a kid's total advancement and setting them up for success in various elements of life.

From Scribbles to Script: A Guide

notes.io

2 mins ago


BACKGROUND A meaningful and purpose-driven life is associated with better health outcomes. We test whether meaning in life is associated with risk of cognitive impairment using data from a large, multi-national study. METHODS Participants (N = 22,514) were from the Survey of Health, Ageing and Retirement in Europe (SHARE). Participants from 14 countries reported on their meaning in life. Cognitive impairment was derived from performance on cognitive tasks administered at baseline and at up to three follow-up waves (waves 2-6 assessed between 2010-2015). RESULTS Lack of meaning in life was associated with a more than 20 % increased risk of incident cognitive impairment over the up to 9-year follow-up (Hazard Ratio = 1.24; 95 % Confidence Interval = 1.17-1.31). Further, compared to participants who reported often feeling meaning in life, participants who reported never feeling meaning in life were at an approximately 75 % increased risk of impairment (Hazard Ratio = 1.75, 95 % Confidence Interval = 1.19-2.57). The association between meaning in life and risk of cognitive impairment was apparent across four regions of Europe (Northern, Southern, Eastern, Western) and in Israel and was not moderated by sociodemographic characteristics. CONCLUSIONS Reporting lower meaning in one's life is associated with risk of incident cognitive impairment. Meaning may be a potential target of intervention for healthier cognitive aging. Phosphorus (P) fertilizer is widely used to increase wheat yield. https://www.selleckchem.com/products/srt2104-gsk2245840.html However, it remains unclear whether prolonged intake of wheat grain that received long-term P application may promote human health risks by influencing heavy metal(loid)s (HMs) accumulation. A 10-year field experiment was conducted to evaluate the effects of continuous P application (0, 25, 50, 100, 200, and 400 kg P ha-1) on human health risks of HMs, including zinc (Zn), copper (Cu), cadmium (Cd), lead (Pb), arsenic (As), nickel (Ni), and chromium (Cr), by ingesting wheat grain. The results showed that P application facilitated Zn, Pb, Cd, and As accumulation in the topsoil. The Zn, Cu, Pb, and Ni concentrations in grain were decreased, while Cd and As were increased by P application. All HMs concentrations of both soil and grain were in the ranges of corresponding safety thresholds at different P levels. The accumulation abilities of Zn, Cu, Pb, and Ni from soil and straw to grain were suppressed by P addition while of As was enhanced. There was no significant difference in the hazard index (HI) of the investigated HMs in all treatments except 25 kg ha-1. The threshold cancer risk (TCR) associated with As and Cd was enhanced, while that of Pb was alleviated as P application increased. Behaviors of Cr from soil to wheat and to humans were not affected by P application. Phosphorus application at a rate of 50 kg ha-1 decreased total non-cancer and cancer risks by 15% and 21%, respectively, for both children and adults, compared to the highest value. In conclusion, long-term optimal application of 50 kg P ha-1 to wheat did not result in additional adverse effects on the total non-carcinogenic or carcinogenic risk caused by the studied HMs to humans through the ingestion of wheat grain. The trade-off between self-maintenance and reproduction has been explored wildly in reptiles. However, the effects of exogenous pollutants on the life history traits of reptiles have not been paid attention to. In the current study, lizards (Eremias argus), living in the soil polluted by perfluorooctanoic acid (PFOA) were selected as the main focus. Bodyweight, survival rate, clutch characteristics and biochemical analysis (immune response, lipid accumulation, sex steroid secretion, antioxidant level, and metabolomics) were investigated and the results revealed that lizards' life-history trade-offs are gender-dependent females were more inclined to choose a "Conservative" life-history strategy. After 60 days of exposure to PFOA, larger body weight, higher survival rate, stronger immune response, and lighter egg mass in females suggested that their trade-offs are more biased towards self-maintenance. Whereas, the "Risk" strategy would more popular among males reduced body weight and survival rate, and suffering from oxidative damage indicated that males made little investment in self-maintenance. Dibutyl phthalate (DBP) is widely used as plasticizer and has been detected in the environment, posing a threat to animal health. However, the effects of DBP on agricultural microbiomes are not known. In this study, DBP levels in black soil were evaluated, and the impact of DBP contamination on the uptake and metabolism of sugars in microbes was assessed by glucose absorption tests, metaproteomics, metabolomics, enzyme activity assays and computational simulation analysis. The results indicated that DBP contamination accelerated glucose consumption and upregulated the expression of porins and periplasmic monosaccharide ATP-binding cassette (ABC) transporter solute-binding proteins (SBPs). DBP and its metabolic intermediates (carboxymuconate and butanol) may form a stable complex with sugar transporters and enhance the rigidity and stability of these proteins. Sugar metabolism resulting in the generation of ATP and reducing agent (NADPH), as well as the expression of some key enzymes (dehydrogenases) were also upregulated by DBP treatment. Moreover, a diverse bacterial community appears to utilize sugar, suggesting that there are widespread effects of DBP contamination on soil microbial ecosystems. The results of this study provide a theoretical basis for investigating the toxicological effects of DBP on microbes in black soil. This work was conducted to study the effect of soil pH (4.0, 6.0, and 8.0) on the transport, fractionation, and oxidation of trivalent chromium [Cr(III)]. Variation in pH altered soil chemical and mineralogical properties such as zeta potential, cation exchange capacity and redox potential of natural soil. Breakthrough curves and batch sorption experiments coupled with fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) analyses demonstrated that the easy mobility of Cr(III) in pH 4.0 soil was dominated by the limited coordination effect. The high retention of Cr(III) in pH 8.0 soil was mainly ascribed to the hydrolysis. Incubation experiments indicated that the proportions of Cr in exchangeable fraction decreased with increasing of soil pH and incubation time, and kinetics analysis revealed that the time dependent transformation was controlled by mass transfer and chemical processes (e.g., hydrolysis, ion association). The XPS confirmed the oxidation of Cr(III) in pH 8.0 soil during the incubation period.

4 mins ago


Some patients with the novel 2019 coronavirus disease (COVID-19) display elevated liver enzymes. Some antiviral drugs that can be used against COVID-19 are associated with a risk of hepatotoxicity.

To analyze the clinical significance of the dynamic monitoring of the liver function of patients with COVID-19.

This was a retrospective study of patients diagnosed with COVID-19 in January and February 2020 at the Department of Infection, Shantou Central Hospital. The exclusion criteria for all patients were (1) History of chronic liver disease; (2) History of kidney disease; (3) History of coronary heart disease; (4) History of malignancy; or (5) History of diabetes. The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase, and total bilirubin of patients with COVID-19 were measured on days 1, 3, 7 and 14 after admission, and compared to non-COVID-19 patents.

Twelve patients with COVID-19 (seven men and five women) and twelve controls (eight men and four ction indicators are not obvious in the early stage of COVID-19, but clinically significant changes might be observed in severe COVID-19.
Tonsillectomy is the most common procedure for treatment of pediatric recurrent acute tonsillitis and tonsillar enlargement that contributes to obstructive sleep apnea hypopnea syndrome. Postoperative hemorrhage of tonsillectomy is a life-threatening complication.

To identify the risk factors that may contribute to primary and secondary post-operative hemorrhage in pediatric tonsillectomy.

The clinical data from 5015 children, 3443 males and 1572 females, aged 1.92-17.08 years, with recurrent tonsillitis and/or tonsil hypertrophy who underwent tonsillectomy in our hospital from January 2009 to December 2018 were retrospectively collected. The variables including sex, age, time of onset, diagnosis, method of tonsillectomy, experience of surgeon, time when the surgery started and monthly average air temperature were abstracted. The patients with postoperative hemorrhage were classified into two groups, the primary bleeding group and the secondary bleeding group, and their characteristics were compared with 0.038, respectively). There was no significant difference in sex, diagnosis, time when the surgery started or monthly average air temperature. There was a significant difference in the intervention measures between the primary bleeding group and the secondary bleeding group (

= 10.947,
= 0.001). The lower pole and middle portion were the common bleeding sites, followed by the upper pole and palatoglossal arch.

The incidence rate of post-tonsillectomy hemorrhage is low. Coblation tonsillectomy and less than 5 years' experience of surgeon contribute to the tendency for primary hemorrhage. Age and time of onset are responsible for secondary hemorrhage.
The incidence rate of post-tonsillectomy hemorrhage is low. Coblation tonsillectomy and less than 5 years' experience of surgeon contribute to the tendency for primary hemorrhage. Age and time of onset are responsible for secondary hemorrhage.
As transjugular intrahepatic portosystemic shunt (TIPS) creation alters the hemodynamic status of the portal system, whether reduced portal blood supply affects the synthetic reserve function of the liver has been the focus of clinical attention. Since the Viatorr stent entered the Chinese market in 2015, it has not yet been widely used in clinical practice. Further, unlike other countries, the main cause of liver cirrhosis in China is viral hepatitis. Therefore, use of the Viatorr stent to establish a TIPS channel in patients with liver cirrhosis with differing etiologies is of great clinical interest.

To investigate factors affecting changes in liver reserve function after TIPS Viatorr stent implantation.

Clinical data from 200 patients with cirrhotic portal hypertension who received TIPS treatment from March 2016 to March 2020 were analyzed retrospectively. The patients were divided into three groups (A-C), according to their disease etiology, with post-hepatitis, autoimmune, and alcoholic cirrhosis,for groups B (10.64 ± 1.90;
= -2.92;
= 0.004) and C (10.82 ± 2.01;
= -3.29;
= 0.001).

Insertion of 8 mm internal diameter Viatorr stent has no significant effects on liver reserve function. Changes of liver reserve function in the medium and long term may be related to the etiology and treatment of portal hypertension.
Insertion of 8 mm internal diameter Viatorr stent has no significant effects on liver reserve function. Changes of liver reserve function in the medium and long term may be related to the etiology and treatment of portal hypertension.
Radiotherapy or chemoradiotherapy is widely used for the treatment of rectal cancer preoperatively. https://www.selleckchem.com/pharmacological_epigenetics.html Although the combination of radiotherapy and chemotherapy as an established preoperative neoadjuvant therapy shows high efficacy in the treatment of rectal cancer, some patients experience a response of poor tolerance and outcomes due to the long duration radiotherapy. The study compared short duration radiotherapy plus chemotherapy
long duration radiotherapy plus chemotherapy for rectal cancer to determine whether short duration radiation treatment should be considered to diminish complications, reduce risk of recurrence and improve survival in patients with rectal cancer.

To evaluate the efficacy and safety of short duration radiotherapy combined with chemotherapy for the treatment of advanced rectal cancer.

One hundred patients with stage IIIB or higher severe rectal cancer were selected as the study subjects at The First Affiliated Hospital of Hebei North University between December 2018 and Decemb observation group and 10.0% in the control group, the distant metastasis rate was 6.0% in the observation group and 8.0% in the control group difference (all
< 0.05).

Short duration radiotherapy combined with chemotherapy can improve the cure rate, prolong the survival time and reduce the incidence of complications in patients with advanced rectal cancer.
Short duration radiotherapy combined with chemotherapy can improve the cure rate, prolong the survival time and reduce the incidence of complications in patients with advanced rectal cancer.

4 mins ago


This paper uses national longitudinal data to analyze the effects of having a teen mother on child health outcomes from birth to young adulthood. We use an empirical strategy that relies on miscarriages to put bounds on the causal effects of teen childbearing. Results show that having a teen mother does not have negative health consequences for children. In addition, children of teen mothers report fewer diagnosed disorders and conditions requiring medical attention. The results suggest that policies focused on delaying teen childbearing will not improve child health outcomes.Spatio-temporal information processing is fundamental in both brain functions and AI applications. Current strategies for spatio-temporal pattern recognition usually involve explicit feature extraction followed by feature aggregation, which requires a large amount of labeled data. In the present study, motivated by the subcortical visual pathway and early stages of the auditory pathway for motion and sound processing, we propose a novel brain-inspired computational model for generic spatio-temporal pattern recognition. The model consists of two modules, a reservoir module and a decision-making module. The former projects complex spatio-temporal patterns into spatially separated neural representations via its recurrent dynamics, the latter reads out neural representations via integrating information over time, and the two modules are linked together using known examples. Using synthetic data, we demonstrate that the model can extract the frequency and order information of temporal inputs. We apply the model to reproduce the looming pattern discrimination behavior as observed in experiments successfully. Furthermore, we apply the model to the gait recognition task, and demonstrate that our model accomplishes the recognition in an event-based manner and outperforms deep learning counterparts when training data is limited.
Most people will experience a traumatic event in their lifetime, but only a subset (<10%) will develop posttraumatic stress disorder (PTSD).

To facilitate prevention and intervention of PTSD, it is important to understand how risk and resilience factors interact with one another to explain individual differences in risk for PTSD, especially in underprivileged groups, who often experience greater burden of trauma and PTSD.

The current study utilized multiple and moderated regression to examine the relation between childhood maltreatment and adulthood PTSD risk in the context of various attachment patterns and emotion dysregulation in a sample (n=856) of mostly low-income, African American participants.

Moderation analysis indicated that the strongest association between self-reported childhood maltreatment and PTSD symptoms was manifest in participants reporting the highest levels of both attachment anxiety and attachment avoidance (b=0.22, 95% CI [0.15, 0.29], p<.001), whereas, among those low on both these dimensions (i.e., more securely attached participants), there was no significant association between childhood maltreatment and current PTSD (b=0.07, 95% CI [-0.01, 0.14], p=.07). Separately, multiple regression predicting current PTSD symptoms revealed an effect size for the two attachment dimensions similar to that of emotion dysregulation, while controlling for childhood maltreatment.

These findings suggest more secure attachment may buffer against the deleterious effects of childhood maltreatment, and both attachment difficulties and emotion dysregulation serve as robust correlates of adulthood PTSD.
These findings suggest more secure attachment may buffer against the deleterious effects of childhood maltreatment, and both attachment difficulties and emotion dysregulation serve as robust correlates of adulthood PTSD.Although many studies have shown that microbial communities play important roles in organic waste composting due to the involvement of specific microbial taxa with metabolic functions, the underlying ecological processes of community assembly and governing factors remain elusive. Thus, a chicken manure composting experiment as a model system of microbially mediated organic waste composting was conducted. Ecological null modeling and metabolic functional prediction combined with electrospray ionization (ESI) Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) were used to quantify assembly processes governing bacterial community composition and functions during composting. The results showed the predominant role of deterministic assembly processes in shifting community compositions both across and within composting stages. Stochastic assembly processes also concomitantly influenced microbial community compositions. Changes in the organic matter (OM) content and its chemical properties and temperature governed bacterial community assembly processes throughout the stages by selecting specific bacterial taxa such as Cardiobacteriales, Bacteroidales, and Lachnospiraceae on day 1, Firmicutes on days 6, 25 and 37, and Sphingobacteriales, Thermoactinomycetaceae, Actinobacteria, and Novibacillus on day 45. These taxa ultimately influenced community functions such as environmental information processing, carbohydrate and amino acid metabolism, cellular processes, and genetic information processes involved in composting. Taken together, this study indicates that deterministic assembly processes governed by OM content and quality as well as temperature influenced microbial community turnover and determined community functions during composting. These results are important for better understanding and predicting microbial-driven composting and for ultimately manipulating microorganisms for environmentally-friendly composting outcomes.In recycling of the spent lithium iron phosphorus (LiFePO4) batteries, the mechanical pretreatment is critical for relieving the pressure of the subsequent recycling process and reducing the cost of whole recycling process. https://www.selleckchem.com/products/SB-525334.html In order to achieve the separation and concentration of the cathode materials, anode materials, copper and aluminum foils from spent LiFePO4 batteries, a novel pneumatic separation combined with froth flotation is designed in this research. A pulsated pneumatic separation with variable-diameter structure separator is used, through which 92.08% of copper and 96.68% of aluminum were recovered. In the pneumatic separation the movement of the copper and aluminum flakes can be described by an improved equivalent diameter method, based on the force analysis of the flaky particles. The froth flotation is utilized to recover the cathode materials and anode materials with the recovery of 92.86% and 83.21%, respectively. A mass balance and a technological route of the recycling process are provided finally.

6 mins ago


erformed with strong activators correlated poorly with anti-Xa activity.Physical activity and exercise induce a complex pattern of adaptation reactions in a broad variety of tissues and organs, particularly the cardiovascular and the musculoskeletal systems. The underlying mechanisms, however, specifically the molecular changes that occur in response to training, are still incompletely understood. Animal models help to systematically elucidate the mechanisms of exercise adaptation. With regard to endurance-based running exercise in mice, two basic regimens have been established forced treadmill running (FTR), usually consisting of several sessions per week, and voluntary wheel running (VWR). However, the effects of these two programs on skeletal muscle molecular adaptation patterns have never been directly compared. To address this issue, in a pilot study, we analyzed the effects of two ten-week training regimens in juvenile, male, C57BL/6 mice moderate-intensity forced treadmill running three-times-a-week, employing a protocol that has been widely used in similar studies before, and voluntary wheel running. Our data suggest that there are similarities, but also characteristic differences in the molecular responses of different skeletal muscle species to the two training regimens. In particular, we found that VWR induces a significant fiber type shift toward more type IIX fibers in the slow, oxidative soleus muscle (p = .0053), but not in the other three muscles analyzed. In addition, while training-induced expression patterns of the two metabolic markers Ppargc1a, encoding Pgc-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) and Nr4a3 (nuclear receptor subfamily 4 group A member 3) were roughly similar, downregulation of the Mstn (myostatin) gene and the "atrogene" Fbox32 could only be observed in response to VWR in specific muscles, such as in the gastrocnemius (p = .0015 for Mstn) and in the tibialis anterior (p = .0053 for Fbox32) muscles, suggesting that molecular adaptation reactions to the two training regimens show distinct characteristics.
To describe the unique complication of hemoperitoneum associated with anaphylaxis.

Retrospective case series from September 2012 to August 2017.

Two private emergency and specialty referral hospitals.

Eleven client-owned dogs diagnosed with anaphylaxis and hemoperitoneum upon presentation or referral.

None.

Inclusion criteria included clinical signs consistent with anaphylaxis (hypotension, tachycardia, vomiting, diarrhea, weakness, collapse, with or without the presence of dermal signs) due to witnessed or unwitnessed presumed bee sting, an elevated alanine aminotransferase (ALT), performance of abdominal FAST (AFAST) examination with an abdominal fluid score, the sonographic presence of gallbladder wall edema, and hemoperitoneum. All dogs (n=11) were managed medically without surgical intervention. 91% (n=10) of dogs survived to discharge.

Hemoperitoneum development can be seen with anaphylactic reactions, though the exact mechanism remains to be fully understood. Medical therapy is warranted and can be successful in these patients; surgery is not indicated to address hemoperitoneum.
Hemoperitoneum development can be seen with anaphylactic reactions, though the exact mechanism remains to be fully understood. Medical therapy is warranted and can be successful in these patients; surgery is not indicated to address hemoperitoneum.
Nusinersen is associated with an improvement in motor function in children with spinal muscular atrophy (SMA) but data on respiratory muscles strength are scarce. Respiratory muscles performance and lung function were evaluated in children with SMA 1c and 2 after six injections of nusinersen (M14). Results from patients with SMA2 were compared with data of age-matched historical controls. Motor function tests (MFM and HINE-2) were assessed at baseline and M14 in the treated patients.

Sixteen children (2 SMA Type 1c and 14 SMA Type 2), mean age 9.4 ± 2.3 years, were included. The data of 14 historical SMA 2 controls (mean age 9.3 ± 1.9 years) were gathered. https://www.selleckchem.com/products/PP121.html The strength of the global inspiratory muscles of SMA 2 treated with nusinersen, assessed on maximal static inspiratory pressure, forced vital capacity, and esophageal pressure during a maximal sniff was significantly better compared with historical controls (p < .05). A significant improvement in MFM and HINE-2 was observed in the patients with 16 SMA treated with nusinersen after 14 months as compared with baseline.

In children with SMA Type 2, respiratory muscle performance was significantly better after six injections of nusinersen as compared with age-matched SMA Type 2 historical controls.
In children with SMA Type 2, respiratory muscle performance was significantly better after six injections of nusinersen as compared with age-matched SMA Type 2 historical controls.
Paraesophageal hernias (PEH) can be associated with obstructive symptoms, but high-resolution manometry (HRM) characteristics have not been described in detail.

HRM studies of confirmed PEH patients (n=60, 66.3±1.5years, 76.7% F), axial hernias (n=125, 56.1±1.1years, 58.4% F), and healthy controls (n=20, 27.9±0.7years, 45% F) were analyzed. Axial hernias (type 1) were compared to PEH subtyped as isolated PEH (type 2), PEH with axial hernia (type 3), PEH with herniated abdominal organs (type 4), and unknown. Distal contractile integral (DCI), esophageal length, lower esophageal sphincter pressures (LESP), EGJ contractile integral (EGJ-CI), and integrated relaxation pressure (IRP) were extracted. Intra-luminal pressures were measured proximal (intrabolus pressure, IBP) and distal (intragastric pressure, IGP) to EGJ. Univariate and multivariate analyses were performed to characterize esophageal and EGJ motor physiology in PEH.

PEH patients had LESP and EGJ-CI similar to controls; axial hernia patients had lower LESP. While IRP was within normal limits, PEH had elevated IBP and IGP, and shorter esophageal length compared to axial hernia and normal controls (P≤.0001 across groups). Short esophageal length was consistent across PEH subtypes (P=.06). On multivariate regression analysis, IBP remained an independent predictor of PEH (P<.0001). Within PEH subtypes, gastric pressure was higher when axial HH was also present, in contrast to isolated PEH (P=.03); other metrics did not differ.

Luminal pressure increase both upstream and downstream of the EGJ on HRM likely represents obstructive phenomena in PEH, identification of which may support suspicion of PEH.
Luminal pressure increase both upstream and downstream of the EGJ on HRM likely represents obstructive phenomena in PEH, identification of which may support suspicion of PEH.