Secondary bleeding was reported mostly in the curettage group (15%). The duration of the operation in (RF) group was relatively long. Halitosis decreased mainly after curettage adenoidectomy.

The endoscopic radio-frequency adenoid ablation surpassed the conventional method. We encourage using Radio-frequency in adenoid surgery as a replacement for the traditional method.
The endoscopic radio-frequency adenoid ablation surpassed the conventional method. We encourage using Radio-frequency in adenoid surgery as a replacement for the traditional method.
Dyslexia is the most common learning disorder that affects 5-10% of school aged children. Eye movement abnormalities and visual processing deficits have been reported in some of dyslexic children. Objective of this study is to compare the eye-movement patterns of Iranian dyslexic children with those of non-dyslexic children as they perform the oculomotor tests and to explore the relationship between their eye-movement patterns and their reading ability.

Binocular eye movements were recorded by oculomotor subtype of videonystagmography (VNG) testing on 30 dyslexic children and 20 non-dyslexic age-matched children (aged 8-12) in both genders. Dyslexic children were diagnosed with DSM-V scale by experts in reading disorder centers. Gain of the pursuit and optokinetic tests and the latency, accuracy and velocity of the saccade test were measured in both groups of dyslexic and non-dyslexic children. The independent samples t-test, Chi-square test and linear regression test in SPSS v. 21 were used to analyze behavioral and eye-movement parameters.

Compared to the non-dyslexic group, dyslexic children presented lower gain in pursuit and optokinetic tests, and increased latency with decreased accuracy in saccade test. All behavioral and eye-movement parameters without saccade velocity differed significantly among two groups.

The atypical eye movement patterns observed in dyslexic children suggests a deficiency in the visual information processing and an immaturity of brain structures responsible for oculomotor skills.
The atypical eye movement patterns observed in dyslexic children suggests a deficiency in the visual information processing and an immaturity of brain structures responsible for oculomotor skills.In this study, we compared the results of biomass and biocarbon content analysis of Solid Refuse Fuels using 14C method and selective dissolution method. Solid Refuse fuel Samples for biomass and biocarbon contents analysis were each collected from the silos and stack of the respective three facilities. Samples collected for 1, 10, 20, and 30 days for each method were analyzed. The analysis data were grouped into sample period, type and method and the optimum method for the detection of the biomass and biocarbon content was estimated. The biomass and biocarbon content showed a partially normal distribution. However, it does not satisfy equal variance. Therefore, we applied the parametric statistics Welch's ANOVA test and the nonparametric statistics Kruskal-Wallis test to compare the means of each sample group. The results of the Kruskal-Wallis test showed that sapmles collected over 20 days at Facility A had the same mean value. Therefore, when analyzing biocarbon content using the 14C method, conducting analyses by collecting exhaust gases for more than 20 days reduces errors in the results.Much of routine cancer care has been disrupted due to the perceived susceptibility to SARS-CoV-2 infection in cancer patients. Here, we systematically review the current evidence base pertaining to the prevalence, presentation and outcome of COVID-19 in cancer patients, in order to inform policy and practice going forwards. A keyword-structured systematic search was conducted on Pubmed, Cochrane, Embase and MedRxiv databases for studies reporting primary data on COVID-19 in cancer patients. Studies were critically appraised using the NIH National Heart, Lung and Blood Institute's quality assessment tool set. The pooled prevalence of cancer as a co-morbidity in patients with COVID-19 and pooled in-hospital mortality risk of COVID-19 in cancer patients were derived by random-effects meta-analyses. In total, 110 studies from 10 countries were included. The pooled prevalence of cancer as a co-morbidity in hospitalised patients with COVID-19 was 2.6% (95% confidence interval 1.8%, 3.5%, I2 92.0%). Specifically, 1.as a history of anti-cancer therapeutic interventions.Surface waters are often charged with high amounts of natural organic matter (NOM), organic contaminants and pathogens. In this work, a Vacuum UV/PMS process (VUV-UVC/PMS) was employed for treating river water, assessing the simultaneous NOM mineralization and bacterial disinfection. The VUV-UVC process (without PMS) decreased TOC concentration from 3.83 to 0.15 mg/L within 20 min, achieving complete disinfection. Adding 5 mg/L PMS increased the rate of TOC removal by 80%; complete removal of TOC was achieved in 15 min and disinfection was attained twice as fast. The mechanism of NOM mineralization was scrutinized; aeration played a considerable role due to oxygen supply, mixing, and inducing in-situ H2O2 production. HO• and SO4•- were the main radical species involved, alongside an important contribution of the matrix; sulfate enhanced TOC removal, due to the formation of additional radicals, underlining its importance. Furthermore, over 99% TOC reduction and complete disinfection was achieved in the VUV-UVC/PMS process operated under continuous-flow mode with a 2-min hydraulic retention time. https://www.selleckchem.com/products/ttnpb-arotinoid-acid.html Finally, the use of Atrazine (ATZ) as a probe compound and a series of scavenging tests led to an integrated proposal for the mineralization of NOM. Accordingly, the VUV-UVC/PMS process is evaluated as an efficient and promising technology for surface water treatment.As a sustainable environmental governance strategy and energy conversion method, photocatalysis has considered to have great potential in this field due to its excellent optical properties and has become one of the most attractive technologies today. Among 2D materials, the emerging two-dimensional (2D) monoelemental materials mainly distributed in the -IIIA, -IVA, -VA and -VIA groups and show excellent performance in solar energy conversion due to their graphene-like 2D atomic structure and unique properties, thereby drawing increasing attention. This review briefly summarizes the preparation processes and fundamental properties of 2D single-element nanomaterials, as well as various modification strategies and adjustment mechanisms to enhance their photocatalytic properties. In particular, this article comprehensively discusses the related practical applications of 2D single-element materials in the field of photocatalysis, including photocatalytic degradation for contaminants removal, photocatalytic pathogen inactivation, photocatalytic fouling control and photocatalytic energy conversion.

01) and perceived positive DC was adversely related with depression symptoms in both and anxiety symptoms in spouses (all p<0.05). More PSS was associated with less depression and anxiety symptoms in both (all p<0.05), and spouse's PSS (b=-0.04, p<0.05) was significantly associated with patient's depression symptoms.

This study highlights the association between perceived negative DC, perceived positive DC and PSS with depression and anxiety symptoms. Focus should be on enhancement of PSS especially in spouses, as they experience a comparable amount of psychosocial distress and have considerable impact on the patient's wellbeing.
This study highlights the association between perceived negative DC, perceived positive DC and PSS with depression and anxiety symptoms. Focus should be on enhancement of PSS especially in spouses, as they experience a comparable amount of psychosocial distress and have considerable impact on the patient's wellbeing.
To compare the pharmacokinetics of amoxicillin (AMX) in obese and nonobese subjects, given as single dose 875-mg tablets.

A prospective, single-centre, open-label, clinical study was carried out involving 10 nonobese and 20 obese subjects given a dose of an AMX 875-mg tablet. Serial blood samples were collected between 0 and 8 hours after administration of AMX and plasma levels were quantified by liquid chromatography-tandem mass spectrometry. The pharmacokinetic parameters (PK) were calculated by noncompartmental analysis and means of the 2 groups were compared using Student t-test. Analysis of correlation between covariates and PK was performed using Pearson's correlation coefficient.

Ten nonobese subjects (mean age 30.6 ± 7.12 y; body mass index 21.56 ± 1.95 kg/m
) and 20 obese subjects (mean age 34.47 ± 7.03 y; body mass index 33.17 ± 2.38 kg/m
) participated in the study. Both maximum concentration (C
; 12.12 ± 4.06 vs. 9.66 ± 2.93 mg/L) and area under the curve (AUC)
(34.18 ± 12.94 mg.h/L vs. 26.88 ± 9.24 mg.h/L) were slightly higher in nonobese than in obese subjects, respectively, but differences were not significant. The volume of distribution (V/F) parameter was statistically significantly higher in obese compared to nonobese patients (44.20 ± 17.85 L vs. 27.57 ± 12.96 L). Statistically significant correlations were observed for several weight metrics vs. https://www.selleckchem.com/products/mizagliflozin.html AUC, C
, V/F and clearance, and for creatinine clearance vs. AUC, C
and clearance.

In obese subjects, the main altered PK was V/F as a consequence of greater body weight. This may result in antibiotic treatment failure if standard therapeutic regimens are administered.
In obese subjects, the main altered PK was V/F as a consequence of greater body weight. This may result in antibiotic treatment failure if standard therapeutic regimens are administered.
We developed a model case study to evaluate three internal standard (IS) application strategies (methods I-III) using the psycholeptic phenobarbital (PB) and the isotopically labelled IS phenobarbital-D5 (PB-D5) from in vitro dosed tissues of the golden apple snail (Pomacea diffusa) by desorption electrospray ionization mass spectrometry imaging (DESI-MSI).

In method I, the IS was deposited as microspots on top of 10 μm thick snail tissues; in method II, a thin IS film was applied; and in method III, the IS was spiked into the DESI solvent spray. DESI-MSI analyses were performed using a Thermo LTQ mass spectrometer equipped with a custom-built DESI source and two-dimensional moving stage. PB (m/z 231) and PB-D5 (m/z 236) were monitored in selected ion monitoring mode between m/z 227 and 239.

The analytical performance of two IS strategies (methods I and II) in DESI-MSI was evaluated based on an intra- and inter-day precision assay, an accuracy assessment, and statistical analysis. In the inter-day DESI- III requires further research for future quantitative DESI-MSI analyses.
Chinese Luzhou-flavor baijiu (LFB) was fermented in an underground cellar, and the bottom and side of the cellar were covered with pit muds (PMs), where the metabolic activity of the microorganisms had a significant effect on the LFB quality. PMs can be divided into aged pit mud (AP) and degenerated pit mud (DP), thus, the qualities of LFB generated from AP and DP were different. In this essay, metatranscriptomics method was applied to illustrate the differences of the two PMs, as well as to search out the pivotal microorganisms and genes influencing the quality of LFB.

Archaea, Clostridium and some thermophilic microorganisms might bring significant effect in AP, while the active eukaryota and Anaeromyxobacter would cause degeneration in PM. Also, the metabolism of carbohydrate and amino acid were more active in AP. What is more, carbohydrate, amino acid and their derivant can produce important organic acids via the activity of the microorganisms in PMs. There were eight critical enzymes noticed in the organic acids metabolic pathway, which were more actively expressed in AP, demonstrating active expression of the critical genes related to organic acid metabolism could have a positive effect on LFB quality.

This study identified specific differences in active microorganisms, active expressed genes and the expression levels of key genes in vital metabolic pathway between AP and DP. Which may be the actual reason for the differences in the quality of LFB made from different PMs. Mastering these results will provide assistance to improve the quality of LFB. © 2021 Society of Chemical Industry.
This study identified specific differences in active microorganisms, active expressed genes and the expression levels of key genes in vital metabolic pathway between AP and DP. Which may be the actual reason for the differences in the quality of LFB made from different PMs. Mastering these results will provide assistance to improve the quality of LFB. © 2021 Society of Chemical Industry.Plant hormones can adjust the physiology and development of plants to enhance their adaptation to biotic and abiotic challenges. Jasmonic acid (JA), one of the immunity hormones in plants, triggers genome-wide transcriptional changes in response to insect attack and wounding. Although JA is known to affect the development of trichomes, epidermal appendages that form a protective barrier against various stresses, it remains unclear how JA interacts with developmental programs that regulate trichome development. In this study, we show that JA affects trichome length in tomato by releasing the transcriptional repression mediated by Jasmonate ZIM (JAZ) proteins. We identified SlJAZ4, a negative regulator preferentially expressed in trichomes, as the critical component in JA signaling in tomato trichomes. We also identified a homeodomain-leucine zipper gene, SlHD8, as the downstream regulator of JA signaling that promotes trichome elongation. SlHD8 is also highly expressed in trichomes and physically interacts with SlJAZ4.

The purification efficiency of the contaminants in the process of photocatalysis is influenced by the co-function of catalytic activity of materials, aquatic environment conditions and characteristics of transmission light. Here, tetracycline hydrochloride (TC-HCl) was introduced as the target pollutant, and the effects of different depths and TC-HCl concentrations on the transmission light intensity and spectral distribution were explored. The results show that incident light decreases with the increase of depth and pollutant concentration. The increase of depth influences the irradiance greatly, however, increase of concentration mainly lead to the narrow of transmission spectral range in the underwater field. The coupling relationship among pollutants, transmission spectral characteristics and photocatalytic reaction efficiency was discussed. Results show that the reduction of the underwater spectral range will reduce the effective response area of the material significantly, which directly leads to the reduction of pollutant removal efficiency in the degradation process. Aiming at different aquatic environment, photocatalytic materials with appropriate response spectral range should be selected to improve the light absorption ability, so that the removal efficiency can be improved significantly.Natural occurring metal-tolerant microbial population have replaced conventional expensive metal remediation approach since the last few years. The present study focuses on investigating the potential of a copper-tolerant plant growth promoting rhizobacterial strain Brevundimonas diminuta MYS6 for Cu bioremediation, plant growth promotion and Cu uptake in Helianthus annuus L. Box-Behnken Design of response surface methodology optimized the influencing parameters such as pH, temperature and Cu concentration. At optimized conditions of pH (5), temperature (32.5 °C) and Cu concentration (250 mg/L), the rhizobacteria followed a sigmoid growth curve pattern with maximum Cu removal of 94.8% in the stationary phase of growth. Cu exposed Brevundimonas diminuta MYS6 produced increased EPS (18.6%), indicating their role in internal defence against Cu stress. The FTIR analysis suggested the role of carboxylic acids, alcohols and aliphatic amine groups in Cu bioremoval. Furthermore, the results of pot experiments conducted with Helianthus annuus L. var. CO4 and Brevundimonas diminuta MYS6 showed enhanced plant growth and Cu uptake. The rhizobacteria increased root and shoot length, fresh and dry plant biomass and leaf chlorophyll by 1.5, 1.7, 9.9, 15.8 and 2.1 fold. The plant biomass mediate enhanced Cu uptake in roots and shoots was found to be 2.98 and 4.1 folds higher when compared to non-inoculated treatment. Henceforth the results of the study evidence the rhizobacterial strain Brevundimonas diminuta MYS6 as an efficient bio-inoculant for copper remediation.Application of activated peroxymonosulfate (PMS) to generate sulfate radical or hydroxyl radical is a promising strategy for wastewater treatment, while our knowledge on the background reaction, namely, the direct interaction between PMS and target contaminants is quite limited. In this contribution, the degradation kinetics, stoichiometry, products and mechanism of the reaction between unactivated PMS and trimethoprim (TMP), one of the most commonly detected micro-pollutants in the aquatic system were investigated systematically. The results indicated that TMP was susceptible to degradation by direct PMS oxidation via a non-radical process. By recording the decay of two reactants simultaneously, the stoichiometric ratio between PMS and TMP was estimated to be approximately 1. Higher PMS levels exhibited a promotion effect on PMS decay. And the degradation was pH-dependent, basic conditions were favorable for TMP degradation, which could be well modeled based on the species-specific reactions. The two amine groups on the pyrimidine ring were identified as the reactive sites. After direct attacks by PMS, they would be oxidized to form hydroxylamine-products, namely, N8-OH-TMP and N9-OH-TMP. These two hydroxylamine-products were quite stable and resistant to further oxidation by PMS, preventing the formation of more toxic nitroso- and nitro-products. The new findings in the present work would provide beneficial information on the strategy choice for the elimination of specific pollutants, like TMP, as PMS also exhibits relatively high reactivity towards them.The interfacial tracer test (ITT) conducted via aqueous miscible-displacement column experiments is one of a few methods available to measure air-water interfacial areas for porous media. The primary objective of this study was to examine the robustness of air-water interfacial area measurements obtained with interfacial tracer tests, and to examine the overall validity of the method. The potential occurrence and impact of surfactant-induced flow was investigated, as was measurement replication. The column and the effluent samples were weighed during the tests to monitor for potential changes in water saturation and flux. Minimal changes in water saturation and flux were observed for experiments wherein steady flow conditions were maintained using a vacuum-chamber system. The air-water interfacial areas measured with the miscible-displacement method completely matched interfacial areas measured with methods that are not influenced by surfactant-induced flow. https://www.selleckchem.com/products/PD-98059.html This successful benchmarking was observed for all three media tested, and over a range of saturations. A mathematical model explicitly accounting for nonlinear and rate-limited adsorption of surfactant at the solid-water and air-water interfaces as well as the influence of changes in surface tension on matric potentials and flow was used to simulate the tracer tests. The independently-predicted simulations provided excellent matches to the measured data, and revealed that the use of the vacuum system minimized the occurrence of surfactant-induced flow and its associated effects. These results in total unequivocally demonstrate that the miscible-displacement ITT method produced accurate and robust measurements of air-water interfacial area under the extant conditions.

All solutions were found to be neutral or mildly alkaline in nature (pH 7-10.3).

Wide variations between claimed and measured F and Ag ion concentrations exist among the different brands of commercially available SDF products.
Wide variations between claimed and measured F and Ag ion concentrations exist among the different brands of commercially available SDF products.
This randomized controlled trial feasibility study aimed to investigate a single-session mindset intervention, incorporating third-wave constructs, within educational settings as a universal tool to promote emotional wellbeing.

Eighty adolescents (age M = 16.63) were randomized to the 30-mincomputer intervention or a usual curriculum waitlist. Outcome measures were administered at baseline, posttreatment, 4-week, and 8-week follow-ups.

Student feedback about the intervention and trial procedure was mainly positive. Participantsengaged with the intervention content and data were suggestive of possible small-large intervention effects for targeted mechanisms of personality mindset and psychological flexibility. Between-group differences over time across wellbeing outcomes of self-compassion, self-esteem, low mood, and anxiety also yielded some promising results, though assessments of reliable change were less clear. No harm was reported.

The intervention and study design were deemed feasible, though areas for improvement were noted. A full-scale trial to determine effectiveness is warranted.
The intervention and study design were deemed feasible, though areas for improvement were noted. https://www.selleckchem.com/products/Sunitinib-Malate-(Sutent).html A full-scale trial to determine effectiveness is warranted.
The ease of online searching has diminished people's expectations of privacy and the ability to control access to information about oneself, which can alter basic assumptions about the therapy relationship.

This grounded theory study explored psychotherapists' experiences of searching online for patients and being searched for by patients, among 28 clinicians of primarily psychodynamic orientation.

Many therapists search online for information about patients, but often minimize or rationalize this action and do not share it with their patients. Meanwhile, while they believe their patients search for them, they find it difficult to raise the topic directly in therapy. Thus, when it comes to online searching and discovery of information, an air of secrecy pervades the therapeutic relationship.

Despite the serious implications that the pervasiveness of online searching has for the treatment relationship, therapists lack sufficient support for exploring their motivations, curiosities, and urges surrounding this action.
Despite the serious implications that the pervasiveness of online searching has for the treatment relationship, therapists lack sufficient support for exploring their motivations, curiosities, and urges surrounding this action.
CT-P13, an infliximab (IFX) biosimilar, was approved for treatment of inflammatory bowel disease. However, no comparison with the originator IFX in this indication has been conducted in Japan where endemic levels of tuberculosis and hepatitis virus infection are not low. We evaluated the safety and efficacy in real-world data of CT-P13 and compared with originator IFX data in Japan.

In a prospective post-marketing surveillance (PMS) study, patients who received CT-P13 in a 28-month period from January 2015 were followed up for 2years. By conducting Japanese administrative database search (DBS) for the same period of PMS, data of the originator IFX including treatment persistence, tuberculosis incidence, and liver injury were analyzed retrospectively and compared with the corresponding PMS data of CT-P13.

CT-P13 persistence in PMS (n=640) and IFX persistence in DBS (n=4113) were almost similar between patients who switched from the originator and patients who continued on the originator, and also between the biologics-naïve patient groups. There were no differences in the incidences of tuberculosis and hepatic injury (Tuberculosis 2 patients [0.31%] with CT-P13, 10 patients [0.24%] with the originator, P=0.75; Hepatic injury 18.5% with CT-P13, 15.4% with the originator, P=0.22). Most of the patients with hepatic injury continued treatment in PMS and DBS at similar rates (80.8% vs 83.6%, P=0.65).

The results of long-term PMS of CT-P13 compared with external reference data from an administrative database suggested that the biosimilar and its originator were comparably useful in real-world clinical practice.
The results of long-term PMS of CT-P13 compared with external reference data from an administrative database suggested that the biosimilar and its originator were comparably useful in real-world clinical practice.The production of dihydrogen (H2 ) is an enigmatic yet obligate component of biological dinitrogen (N2 ) fixation. This study investigates the effect on H2 production by N2 fixing cyanobacteria when they are exposed to either air or a gas mixture consisting of argon, oxygen, and carbon dioxide (ArO2 CO2 ). In the absence of N2 , nitrogenase diverts the flow of electrons to the production of H2 , which becomes a measure of Total Nitrogenase Activity (TNA). This method of argon-induced hydrogen production (AIHP) is much less commonly used to infer rates of N2 fixation than the acetylene reduction (AR) assay. We provide here a full evaluation of the AIHP method and demonstrate its ability to achieve high-resolution measurements of TNA in a gas exchange flow-through system. Complete diel profiles of H2 production were obtained for N2 fixing cyanobacteria despite the absence of N2 that broadly reproduced the temporal patterns observed by the AR assay. Comparison of H2 production under air versus ArO2 CO2 revealed the efficiency of electron usage during N2 fixation and place these findings in the broader context of cell metabolism. Ultimately, AIHP is demonstrated to be a viable alternative to the AR assay with several additional merits that provide an insight into cell physiology and promise for successful field application.Here, we review the molecular mechanism and pharmacokinetics of flavonoids in the treatment of resistant EGF receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) and particularly the possible mechanism(s) of delicaflavone, a biflavonoid extracted from Selaginella doederleinii Hieron. EGFR TK inhibitors (EGFR-TKI) are ubiquitously used in the treatment of NSCLC bearing EGFR mutations. However, patients treated with EGFR-TKI inevitably and continuously develop resistance. In laboratory studies, flavonoids, as potential adjuvants for cancer chemotherapy, exhibited anti-cancer properties such as inhibition of chemoresistance by interference with ABC transporters-induced drug efflux, curbing of c-MET amplification, or reversal of T790M mutation-mediated resistance. The current review aims at summarizing the association between the anti-cancer potentials of flavonoids and their possible regulatory roles in certain types of mutation that could trigger EGFR-TKI resistance in NSCLC. Potential practical applications of these phytochemicals, as well as the relevant pharmacokinetics, are also discussed.

9), 7.2 mmHg (95% CI 0.8, 13.6), and 21.2 bpm (95% CI 5.8, 36.6) in diastolic BP (DBP, lag1), mean arterial BP (MABP, lag1), and HR (lag01), respectively. Meanwhile, the serum concentrations of hs-CRP, 8-OHdG, and t-PA were all increased by O3 exposure, but the PMA level was decreased. Stratification analyses showed that the estimated effects of O3 on DBP, MABP, and HR in GSTM1-sufficient subjects were significantly higher than in GSTM1-null subjects. https://www.selleckchem.com/products/jq1.html Moreover, GSTM1-null genotype enhanced O3-induced increases, albeit insignificant, in levels of serum hs-CRP, 8-OHdG, and t-PA compared with GSTM1-sufficient genotype. Insignificant increases in hs-CRP and t-PA were also detected in GSTT1-null subjects. Taken together, our findings indicate that acute exposure to ambient O3 induces autonomic alterations, systemic inflammation, oxidative stress, and fibrinolysis in healthy young subjects. GSTM1 genotype presents the trend of modifying O3-induced cardiovascular effects. There are indications that drinking water may contribute to endemic gastrointestinal illness (GII) even when the drinking water quality meets current standards, but the knowledge is limited. In this population-based prospective study, we assessed if changes in municipal drinking water production affected the GII incidence, by collecting self-reported GII episodes among the population in two municipalities during calendar time-specific inter-annual periods. About 2600 adults in central Sweden and 2600 adults (including 700 households with children aged 0-9 years) in Southwest Sweden, were followed during a baseline and a follow-up period in 2012-2016. Monthly reports of episodes and symptoms of GII were collected by SMS. The following drinking water related changes were assessed Change 1 (adults); a municipality with a groundwater treatment, changed to a different groundwater source with UV treatment; Change 2 (adults); a municipality with a surface water treatment changed to a groundwater source with UV treatment; and Change 3a (adults) and 3b (children) a municipality with a surface water treatment changed to a new surface water source, having a treatment with a higher pathogen reduction. We observed no evidence that changes in raw water source and/or improved pathogen removal in the drinking water treatment affected the risk of GII among adults. Among children aged 0-9 years participating in Change 3b, we observed a 24% relative risk reduction in GII incidence. These results suggest that improved water treatment may reduce the disease burden of GII in children even in settings in which water treatment efficacy meets current quality standards. Vehicles generate particulate matter (PM) in significant amounts as their brake systems wear. These particles can influence air quality and their transport/deposition may affect the edaphic and aquatic ecosystems. As part of the LOWBRASYS H2020 project, new more eco-friendly brake disc and pad formulations were developed. PMs generated from traditional (FM1-BD1) and innovative (FM4-BD2, FMB-BD7) brake systems in bench tests were studied. The PMs' physical/chemical characteristics were preliminarily investigated. To study the possible environmental impact of the nano-micro particulate, we used a battery of ecotoxicological tests. We employed the microalga Pseudokirchneriella subcapitata, the crustacean Daphnia magna and the bacteria Vibrio fischeri as aquatic bioindicators, while for the edaphic ecosystem we used the seeds of Lepidium sativum and Sorghum saccharatum, the nematode Caenorhabditis elegans, the earthworm Eisenia andrei and the ameba Dictyostelium discoideum. The results showed a higher sensitivityects of the environmental pollution. The effects of lead as a dietary pollutant remain a global public health concern that needs urgent resolution. Children are highly susceptible to the adverse outcomes of lead pollution, as even low levels of lead may cause irreversible damage to intellectual development. Since several sources of lead exposure are present in the environment, it is necessary to identify the attributable burden of lead-related diseases arising from different exposure sources. In the present study, we used epidemiological data from studies around the nation to estimate the burden of mild intellectual disability (MID) attributed to lead exposure sources by using disability-adjusted life years (DALYs). To this end, a dose-response approach was used and a model comprising three components was established exposure, dose-response, and DALYs module. In Chinese children aged 0-6 years, blood lead levels (BLLs) of 5.34 ± 3.09 μg/dL resulted in a MID incidence rate of 12.84 cases per 1000 children, with an estimated burden of disease (BoD) of 42.23 DALYs per 1000 children. Owing to dietary lead exposure, 36.64 healthy life years per 1000 children were lost, which was notably higher than the outcomes associated with exposure from other sources. This was consistent with the result that dietary exposure was the main contributor to children's lead exposure, accounting for 86.76%. According to the regional distribution based on the existing literature, the areas in China with higher BLLs were Heilongjiang, Shanxi, and Jiangxi. Our findings provided the information for lead risk management decisions and policies making. Groundwater contamination is an ever-growing environmental issue that has attracted much and undiminished attention for the past half century. Groundwater contamination may originate from both anthropogenic (e.g., hydrocarbons) and natural compounds (e.g., nitrate and arsenic); to tackle the removal of these contaminants, different technologies have been developed and implemented. Recently, bioelectrochemical systems (BES) have emerged as a potential treatment for groundwater contamination, with reported in situ applications that showed promising results. Nitrate and hydrocarbons (toluene, phenanthrene, benzene, BTEX and light PAHs) have been successfully removed, due to the interaction of microbial metabolism with poised electrodes, in addition to physical migration due to the electric field generated in a BES. The selection of proper BESs relies on several factors and problems, such as the complexity of groundwater and subsoil environment, scale-up issues, and energy requirements that need to be accounted for.