Humans are strongly affected by social exclusion, a multifaceted and complex phenomenon of social life. However, individuals tend to respond differently depending on a multitude of individual and contextual factors. Firstly, with a view to increasing the ecological validity and experimental control of an exclusion manipulation in the laboratory setting, we made use of immersive virtual environment technology (IVET; an Oculus Rift Virtual Reality headset) to create a new exclusion paradigm. Secondly, given that a recent meta-analytic report on reflexive responses (i.e., affect and physiology) to manipulations of exclusion in the laboratory setting cites inconsistencies across findings (Blackhart et al., 2009), we focused on the form of exclusion manipulated to illustrate how this factor may help to explain the divergences in responses. We thus investigated how explicit and implicit forms of social exclusion may have a differential impact on self-reported affect, as well as on electrodermal and cardiovascular activity. Results from this laboratory study conducted with a varied sample of the local population made salient the affordances of IVET as a tool in exclusion research. They also helped to reconcile the conflicting findings in the literature relating to differences in the level of negative affect generated and shed light on physiological arousal in the wake of being excluded in different ways.Sleep is a fundamental property conserved across species. The homeostatic induction of sleep indicates the presence of a mechanism that is progressively activated by the awake state and that induces sleep. Several lines of evidence support that such function, namely, sleep need, lies in the neuronal assemblies rather than specific brain regions and circuits. However, the molecular mechanism underlying the dynamics of sleep need is still unclear. This review aims to summarize recent studies mainly in rodents indicating that protein phosphorylation, especially at the synapses, could be the molecular entity associated with sleep need. Genetic studies in rodents have identified a set of kinases that promote sleep. The activity of sleep-promoting kinases appears to be elevated during the awake phase and in sleep deprivation. Furthermore, the proteomic analysis demonstrated that the phosphorylation status of synaptic protein is controlled by the sleep-wake cycle. Therefore, a plausible scenario may be that the awake-dependent activation of kinases modifies the phosphorylation status of synaptic proteins to promote sleep. We also discuss the possible importance of multisite phosphorylation on macromolecular protein complexes to achieve the slow dynamics and physiological functions of sleep in mammals.Approximately half of the world's population is bilingual or multilingual. The bilingual advantage theory claims that the constant need to control both known languages, that are always active in the brain, to use the one suitable for each specific context improves cognitive functions and specifically executive functions. However, some authors do not agree on the bilingual effect, given the controversial results of studies on this topic. This systematic review aims to summarize the results of studies on the relationship between bilingualism and executive functions. The review was conducted according to PRISMA-statement through searches in the scientific database PsychINFO, PsycARTICLES, MEDLINE, and PUBMED. Studies included in this review had at least one bilingual and monolingual group, participants aged between 5 and 17 years, and at least one executive function measure. https://www.selleckchem.com/products/fx-909.html Studies on second language learners, multilingual people, and the clinical population were excluded. Fifty-three studies were included in the systematic review. Evidence supporting the bilingual effect seems to appear when assessing inhibition and cognitive flexibility, but to disappear when working memory is considered. The inconsistent results of the studies do not allow drawing definite conclusions on the bilingual effect. Further studies are needed; they should consider the role of some modulators (e.g., language history and context, methodological differences) on the observed results.Solving problems that are perceptually dissimilar but require similar solutions is a key skill in everyday life. In adults, this ability, termed analogical transfer, draws on memories of relevant past experiences that partially overlap with the present task at hand. Thanks to this support from long-term memory, analogical transfer allows remarkable behavioral flexibility beyond immediate situations. However, little is known about the interaction between long-term memory and analogical transfer in development as, to date, they have been studied separately. Here, for the first time, effects of age and memory on analogical transfer were investigated in 2-4.5-olds in a simple tool-use setup. Children attempted to solve a puzzle box after training the correct solution on a different looking box, either right before the test or 24 h earlier. We found that children (N = 105) could transfer the solution regardless of the delay and a perceptual conflict introduced in the tool set. For children who failed to transfer (N = 54) and repeated the test without a perceptual conflict, the odds of success did not improve. Our findings suggest that training promoted the detection of functional similarities between boxes and, thereby, flexible transfer both in the short and the long term.
Studies on autistic strengths are often focused on what they reveal about autistic intelligence and, in some cases, exceptional and atypical reasoning abilities. An emerging research trend has demonstrated how interests and strengths often evident in autism can be harnessed in interventions to promote the well-being, adaptive, academic and professional success of autistic people. However, abilities in certain domains may be accompanied by major limitations in others, as well as psychiatric and behavioral issues, which may challenge their inclusion in support programs.

To provide an in-depth, pragmatic, real-life example of the psychological and psychiatric management of interests and strengths in an autistic adolescent.

An autistic teenager, C.A., with above-average calendar calculation and musical abilities, received psychiatric, neuropsychological, and language standardized and clinical assessments, combined with a measurement of his musical and calendar calculation abilities. C.A. and his parents then received psychiatric and psychological support over a 14-month period, targeting their perceptions of C.

The aforementioned were evaluated as a measure of cardiorespiratory function and functional ability in the exercise groups and compared to those obtained in the control group. High-speed power training led to greater improvement in patients compared with low-speed strength training.

Multicomponent exercise involving high-speed power training was beneficial in helping patients with stroke regain cardiorespiratory fitness, physical function, and muscular strength.
Multicomponent exercise involving high-speed power training was beneficial in helping patients with stroke regain cardiorespiratory fitness, physical function, and muscular strength.
Anxiety disorders affect many people around the world and women are more affected than men. Physical exercise might be an important nonpharmacological tool to ameliorate these disorders. The aim of this study was to compare state anxiety level and enjoyment between a dance exergame session and a traditional aerobic exercise.

Twenty healthy young women completed 3 visits, on separate days. At the first visit, participants performed a graded exercise testing and familiarization procedures. In other two visits, participants completed two exercise sessions (dance exergame and traditional aerobic exercise), with similar intensities and duration. Each session lasted approximately 45 minutes. State anxiety level was evaluated before, immediately post- and 10 minutes post sessions. Enjoyment was evaluated immediately post sessions.

There was a significant interaction between session and time (p<0.001), a main effect of time (p=0.007) but no significant main effect of session (p=0.057) on state anxiety level. State anxiety level immediately post (p<0.001) and 10 minutes post-session (p<0.001) were significantly lower than pre-dance exergame session. There were no significant changes between pre-, immediately post and 10 minutes post-traditional aerobic exercise session (p>0.05). State anxiety level at immediately post dance exergame session was significantly lower than immediately post traditional aerobic exercise session (p=0.026). Dance exergame session was significantly more enjoyable than traditional aerobic exercise session (p<0.0001).

Dance exergames might be used as a tool to reduce anxiety level in young women.
Dance exergames might be used as a tool to reduce anxiety level in young women.
This study aimed to analyze injuries of functional fitness participants through a systematic review.

A systematic search of the literature was conducted in CINAHL, EMBASE, PEDro, PubMed, SCOPUS, SPORTDiscus, and Web of Science, supplemented by searching in the grey literature, from 2017 to November 2020. This systematic review followed the PRISMA guidelines and was documented in the PROSPERO registry (CRD42020201259). Two reviewers independently extracted data including methodological (age, sex, time of practice, location, period, time frame, and completion rate) and injury (definition, diagnosis, prevalence, incidence, severity, mechanism, type, location, risk factors, and treatment) variables, as well as assessing study quality and risk of bias.

Twenty-six studies were included (10967, range 6-3049, participants). Injury was defined fairly differently across studies. The majority of studies used a retrospective study design and the main variables reported were prevalence, body location, and associated factors of injuries. The mean prevalence of musculoskeletal injuries was 32.8%, ranging from 2.4 to 60.6%, and the injury incidence per 1000 hours ranged from 0.21 to 67 36. The most affected body location in the studies was the shoulder, followed by lumbar spine, and knee. Muscle, joint, and ligament/tendon injuries were the most frequently reported. The majority of studies were of moderate methodological quality. All studies were considered as high risk of bias.

This review broadened the scope of 75 previous reviews on injuries in functional fitness. There have been few investigations regarding severity, mechanism, and treatment of injuries, so further research is warranted.
This review broadened the scope of 75 previous reviews on injuries in functional fitness. There have been few investigations regarding severity, mechanism, and treatment of injuries, so further research is warranted.
To date, there is no evidence to support the optimal competition strategy for success in powerlifting competitions. The purpose of this study was to analyse Powerlifting (PL) competition data to assess the relationship between squat attempts, the success of each lift attempt, and weight increase between attempts, with winning.

10,672 individual competition entries (males n = 6617, females n = 4,055) were included within the analysis from 'raw' Powerlifting Australia sanctioned competitions held between 2008 and 2019. https://www.selleckchem.com/products/deruxtecan.html We reported Cohen's d, statistical significance, 95% confidence intervals and the univariate odds of winning an event. Factors were assessed by separate simple logistic regression and reported as an odds ratio.

Overall, first squat attempt weight for those who won was on average 7.0kg greater (P<0.001, d=0.14 [0.10, 0.18]) than for non-winners. In the total sample, athletes selected opening attempts which were an average of 92% of their achieved maximum on the day with 93.5% of competitors improving on this weight in subsequent attempts. Winners had a 0.5kg (P<0.001, d=0.10 [0.06, 0.14]) greater absolute increase in weight between first and second lift attempts than non-winners. Overall, ~68% of winners successfully lifted their third attempt weight compared to ~64% of non-winners (P<0.001).

A powerlifting athlete's odds of winning a competition overall are significantly increased by selecting a larger opening squat attempt weight than competitors and completing the attempt successfully. The opening squat may be one of the most important lifts during competition.
A powerlifting athlete's odds of winning a competition overall are significantly increased by selecting a larger opening squat attempt weight than competitors and completing the attempt successfully. The opening squat may be one of the most important lifts during competition.

How to Buy a Driving License in the Czech Republic: What You Need to Know

Obtaining a driving license is often viewed as an initiation rite for many people. It opens doors to liberty, self-reliance, and convenience, whether you require to commute to work, travel with family and friends, or simply explore your surroundings. In the Czech Republic, driving is an important aspect of life for lots of individuals, offered the country's efficient network of roadways and highways. While properly to acquire a driving license in the Czech Republic is to enlist in a licensed driving school, pass the needed tests, and fulfill all regulatory requirements, there has been increasing talk about alternative, prohibited methods to "buy" a driving license.

This article will explore both the legal and unlawful paths to acquiring a driving license in the Czech Republic, with a strong emphasis on why you need to constantly abide by the law and avoid dubious faster ways.

The Legal Way to Obtain a Driving License in the Czech Republic
If you prepare to drive in the Czech Republic, the government mandates that you hold a legitimate driving license issued either in the country or an acknowledged equivalent from another country. Here's a detailed outline of the legal procedure to get your license:

Enrollment in a Driving School:
The initial step is to register for a licensed driving school. These schools offer theoretical and practical training to make sure that you fully understand Czech traffic policies and can safely run a lorry.

Theory Lessons:
As part of your driving school coursework, you'll need to finish a series of theoretical lessons. This consists of learning about road signs, traffic laws, and safe driving practices.

Practical Driving Lessons:
Under the guidance of a qualified instructor, you'll get hands-on driving experience. Depending on the type of license you're getting (e.g., car, motorcycle, truck), the number and format of lessons may vary.

Medical Certification:
Before you can continue with the testing process, you'll need to provide a medical certificate to confirm that you fulfill the physical and psychological requirements required for driving.

Taking the Tests:
The last action includes passing the main examinations, that include a written theory test and a useful driving test on the roadway. Both tests are supervised by traffic authorities to guarantee compliance with Czech policies.

Getting Your License:
Once you've successfully completed your training and passed the required tests, your driving license will be issued. Congratulations-- you're now legally permitted to drive in the Czech Republic!

This procedure is strenuous for a factor: guaranteeing that all drivers receive sufficient training and comprehend their responsibilities behind the wheel.

The Illegal Route: Buying a Driving License
In recent years, reports have emerged about people attempting to "buy" driving licenses in the Czech Republic. This unlawful practice typically involves preventing the legal requirements, such as participating in driving school or passing the tests, by paying a substantial amount to corrupt individuals or underground networks.

How It Works:
Some deceitful services claim to supply genuine or counterfeit driving licenses for sale. These services typically run online or through shady contacts. They may even declare to have connections within the system to produce "official" licenses without going through the training or testing procedure.

Why It's a Bad Idea:

It's Illegal:
Buying a driving license is strictly against Czech law. If caught, both the purchaser and the seller face serious legal consequences, such as heavy fines, loss of driving advantages, and even jail time.

You Endanger Yourself and Others:
Driving without adequate training puts yourself and everybody else on the roadway at risk. The practical lessons and testing process exist to guarantee that you can operating an automobile securely. An absence of correct skills can result in serious accidents.

Threat of Fraud:
Much of the services that promise to offer you a driving license are rip-offs. You might end up paying thousands of euros only to receive a fake or void document that can't be used lawfully.

https://telegra.ph/How-Much-Does-A-Driving-License-Cost-In-The-Czech-Republic-The-Secret-Life-Of-How-Much-Does-A-Driving-License-Cost-In-The-Czech--01-18 of Reputation:
Getting caught with an illegally acquired license can taint your professional and personal credibility, particularly if legal authorities are included.

Deportation for Foreigners:
Expats and foreigners who resort to acquiring licenses deal with extra threats such as deportation, blacklisting from EU countries, or losing their residency rights.

Why You Should Stick to the Legal Process
While the legal path to acquiring a driving license in the Czech Republic may appear prolonged and often tough, it's necessary to appreciate the law, both for your security and the security of others. Driving is a privilege that comes with considerable duty. Cutting corners not just threatens your stability however also positions unnecessary dangers.

Moreover, the Czech federal government has stringent policies in location to prevent and prosecute fraudulent activities connected to driving licenses. As authorities end up being more vigilant, the opportunities of getting caught and penalized are only increasing.

Tips for Success in the Legal Process
Getting your driving license legally in the Czech Republic doesn't have to be an overwhelming process. Here are some pointers to help you prosper:

Select a Reputable Driving School: Select a licensed school with a good track record and skilled instructors to guide you through the process.

Practice Diligently: Dedicate yourself to both the theoretical and practical aspects of driving. Routine practice will develop your confidence for the last examinations.

Learn the Local Rules: Czech traffic regulations might differ from those in your house nation. Acquaint yourself with local laws and road indications to make your knowing experience smoother.



Look For Help if Needed: If you're struggling with any part of the process, consult your driving trainer or enlist in extra lessons.

Conclusion
While the concept of "buying" a driving license in the Czech Republic might appear tempting to some, the risks and repercussions far exceed any perceived benefits. By following the proper legal path, you can make sure that you are well-prepared to drive safely and properly. Keep in mind, driving is more than simply a convenience; it's a duty to secure your life and the lives of others on the road. Always pick https://postheaven.net/zebracd0/what-freud-can-teach-us-about-create-a-fake-driving-license and legal route-- it will serve you well in the long run.

In recent years, the fibroblast growth factor receptor (FGFR) pathway has been proven to be an important therapeutic target in bladder cancer. FGFR-targeted therapies are effective for patients with FGFR mutation, which can be discovered through genetic sequencing. However, genetic sequencing is not commonly performed at diagnosis, whereas a histologic assessment of the tumor is. We aim to computationally extract imaging biomarkers from existing tumor diagnostic slides in order to predict FGFR alterations in bladder cancer.

This study analyzed genomic profiles and H&E-stained tumor diagnostic slides of bladder cancer cases from The Cancer Genome Atlas (n=418 cases). A convolutional neural network (CNN) identified tumor-infiltrating lymphocytes (TIL). The percentage of the tissue containing TIL ("TIL percentage") was then used to predict FGFR activation status with a logistic regression model.

This predictive model could proficiently identify patients with any type of FGFR gene aberration using the CNN-based TIL percentage (sensitivity=0.89, specificity=0.42, AUROC=0.76). https://www.selleckchem.com/products/en450.html A similar model which focused on predicting patients with only FGFR2/FGFR3mutation was also found to be highly sensitive, but also specific (sensitivity=0.82, specificity=0.85, AUROC=0.86).

TIL percentage is a computationally derived image biomarker from routine tumor histology that can predict whether a tumor has FGFR mutations. CNNs and other digital pathology methods may complement genome sequencing and provide earlier screening options for candidates of targeted therapies.
TIL percentage is a computationally derived image biomarker from routine tumor histology that can predict whether a tumor has FGFR mutations. CNNs and other digital pathology methods may complement genome sequencing and provide earlier screening options for candidates of targeted therapies.
Infertility affects 15%-25% of all couples during their reproductive life span. It is a significant societal and public health problem with potential psychological, social, and economic consequences. Furthermore, infertility has been linked to adverse long-term health outcomes. Despite the advanced diagnostic and therapeutic techniques available, approximately 30% of infertile couples do not obtain a live birth after fertility treatment. For these couples, there are no further options to increase their chances of a successful pregnancy and live birth.

Three overall questions will be studied (1) What are the risk factors and natural life courses of infertility, early embryonic loss, and adverse pregnancy outcomes? (2) Can we develop new diagnostic and prognostic biomarkers for fecundity and treatment success? And (3) what are the health characteristics of women and men in infertile couples at the time of fertility treatment and during long-term follow-up?

ReproUnion Biobank and Infertility Cohort (RUBIC)tic options for this important societal problem.The synthesis of 3-(1,2,4-oxadiazolyl)-5-nitratomethyl isoxazole (C6 H4 N4 O5 ), its physical properties, and its theoretical performances are described. This energetic material was found to have a melting point range of 76.6-79.2 °C, and a thermal onset decomposition temperature of 184.5 °C. These thermal features put this material into the standalone melt-castable explosive class. The material was found to have TNT performance, and was found to be insensitive to impact, friction, and electrostatic discharge, despite having a nitric ester functionality. A critical reaction in making this molecule was the desymmetrization of diaminoglyoxime. The optimization of this transformation is described. Previous reports of this desymmetrization were found to be inaccurate, as the desymmetrization reaction produces a co-crystal of mono- and bi-1,2,4-oxadiazole products.Abnormallyactivated FGFR1 has been validated as a therapeutic target for differentcancers. Although a variety of FGFR inhibitors have shown benefit in manyclinical patients with FGFR1 aberration, FGFR1 mutant resistance such as V561Mmutation, has been reported. To date however, no FGFR inhibitors have beenapproved to treat patients with FGFR mutant resistance. Herein, we report that GZD824, athird generation ABL inhibitor (Phase II, China), overcomes FGFR1-V561F/M mutant resistance in vitro and in vivo. GZD824potently suppresses FGFR1/2/3 with an IC50 value of 4.14 ± 0.96, 2.77 ± 0.082, and 8.10 ± 0.15 nmol/L. It effectively overcomes FGFR1-V561F/M and other mutantresistance in Ba/F3 stable cells (IC50 8.1-55.0 nM), and effectively inhibits the growth of Ba/F3-FGFR1-V561F/M mutantxenograft tumors in vivo (TGI=73.4%, 49.8% at20mg/kg, p.o, q2d). GZD824may be considered to be an effective drug to treat patients with FGFR1 abnormalactivation or mutant resistance in clinical trials.
Colorectal cancer is the second-leading cause of cancer-related mortality in the United States and a leading cause of cancer-related mortality worldwide. Loss of SMAD4, a critical tumor suppressor and the central node of the transforming growth factor-beta superfamily, is associated with worse outcomes for colorectal cancer patients; however, it is unknown whether an RNA-based profile associated with SMAD4 expression could be used to better identify high-risk colorectal cancer patients.

Identify a gene expression-based SMAD4-modulated profile and test its association with patient outcome.

Using a discovery dataset of 250 colorectal cancer patients, we analyzed expression of BMP/Wnt target genes for association with SMAD4 expression. Promoters of the BMP/Wnt genes were interrogated for SMAD-binding elements. Fifteen genes were implicated and three tested for modulation by SMAD4 in patient-derived colorectal cancer tumoroids. Expression of the 15 genes was used for unsupervised hierarchical clustering of stic potential for stage II and III colorectal cancer patients.
A SMAD4-modulated gene expression profile identified high-risk stage II and III colorectal cancer patients, can predict disease-free survival, and has prognostic potential for stage II and III colorectal cancer patients.The second biannual Alpine Winter Conference on Medicinal and Synthetic Chemistry (short Alpine Winter Conference) took place January 19-23, 2020, in St. Anton in western Austria. There were roughly 180 attendees from around the globe, making this mid-sized conference particularly conducive to networking and exchanging ideas over the course of four and a half days. This report summarizes the key events and presentations given by researchers working in both industry and academia.

GMY will complete validated measures about the feasibility, acceptability, and appropriateness of the web-based human-centered design methods (a priori benchmarks for success means >3.75 on each 5-point scale).

This study was funded in February 2020. Data collection began in August 2020 and will be completed by April 2021.

Through rigorous testing of the feasibility of our web-based human-centered design methodology, our study may help demonstrate the use of human-centered design methods to engage harder-to-reach stakeholders and actively involve them in the co-creation of relevant interventions. Successful completion of this project also has the potential to catalyze intervention research to address ARA inequities for SGMY. Finally, our approach may be transferable to other populations and health topics, thereby advancing prevention science and health equity.

DERR1-10.2196/26554.
DERR1-10.2196/26554.
The integration of data from disparate sources could help alleviate data insufficiency in real-world studies and compensate for the inadequacies of single data sources and short-duration, small sample size studies while improving the utility of data for research.

This study aims to describe and evaluate a process of integrating data from several complementary sources to conduct health outcomes research in patients with non-small cell lung cancer (NSCLC). The integrated data set is also used to describe patient demographics, clinical characteristics, treatment patterns, and mortality rates.

This retrospective cohort study integrated data from 4 sources administrative claims from the HealthCore Integrated Research Database, clinical data from a Cancer Care Quality Program (CCQP), clinical data from abstracted medical records (MRs), and mortality data from the US Social Security Administration. Patients with lung cancer who initiated second-line (2L) therapy between November 01, 2015, and April 13, 2018, w from MRs, health plan claims, and other sources of clinical care may improve the ability to assess emerging treatments.
New opportunities to create and evaluate population-based selective prevention programs for suicidal behavior are emerging in health care settings. Standard depression severity measures recorded in electronic medical records (EMRs) can be used to identify patients at risk for suicide and suicide attempt, and promising interventions for reducing the risk of suicide attempt in at-risk populations can be adapted for web-based delivery in health care.

This study aims to evaluate a pilot of a psychoeducational program, focused on developing emotion regulation techniques via a web-based dialectical behavior therapy (DBT) skills site, including four DBT skills, and supported by secure message coaching, including elements of caring messages.

Patients were eligible based on the EMR-documented responses to the Patient Health Questionnaire indicating suicidal thoughts. We measured feasibility via the proportion of invitees who opened program invitations, visited the web-based consent form page, and consented; accea high-risk population and offer key elements of caring messages and DBT adapted for a low-intensity intervention. https://www.selleckchem.com/products/blu-285.html A randomized trial evaluating the effectiveness of this program is now underway (ClinicalTrials.gov NCT02326883).
Consumer-based physical activity trackers have increased in popularity. The widespread use of these devices and the long-term nature of the recorded data provides a valuable source of physical activity data for epidemiological research. The challenges include the large heterogeneity between activity tracker models in terms of available data types, the accuracy of recorded data, and how this data can be shared between different providers and third-party systems.

The aim of this study is to develop a system to record data on physical activity from different providers of consumer-based activity trackers and to examine its usability as a tool for physical activity monitoring in epidemiological research. The longitudinal nature of the data and the concurrent pandemic outbreak allowed us to show how the system can be used for surveillance of physical activity levels before, during, and after a COVID-19 lockdown.

We developed a system (mSpider) for automatic recording of data on physical activity from particip in moderate-to-vigorous physical activity was observed for several monthly comparisons after the lockdown period and when comparing March-December 2019 with March-December 2020.

mSpider is a working prototype currently able to record physical activity data from providers of consumer-based activity trackers. The system was successfully used to examine changes in physical activity levels during the COVID-19 period.
mSpider is a working prototype currently able to record physical activity data from providers of consumer-based activity trackers. The system was successfully used to examine changes in physical activity levels during the COVID-19 period.
Addressing the modifiable health behaviors of cancer survivors is important in rural communities that are disproportionately impacted by cancer (eg, those in Central Appalachia). However, such efforts are limited, and existing interventions may not meet the needs of rural communities.

This study describes the development and proof-of-concept testing of weSurvive, a behavioral intervention for rural Appalachian cancer survivors.

The Obesity-Related Behavioral Intervention Trials (ORBIT) model, a systematic model for designing behavioral interventions, informed the study design. An advisory team (n=10) of community stakeholders and researchers engaged in a participatory process to identify desirable features for interventions targeting rural cancer survivors. The resulting multimodal, 13-week weSurvive intervention was delivered to 12 participants across the two cohorts. Intervention components included in-person group classes and group and individualized telehealth calls. Indicators reflecting five feasiframework) and small-scale proof-of-concept studies when adapting or developing behavioral interventions, as doing so identifies the intervention's potential for feasibility and areas that need improvement before time- and resource-intensive efficacy trials. This could support a more efficient translation into practice.