https://mises.org/mises-wire/revolution-continues-ranks-anti-fed-republicans-grow

In order to support the best optimized design or strategy based on life-cycle data, the interrelation mechanisms between structure-form and structure-performance should be considered simultaneously and comprehensively besides of the material-property relationship. Here, the structure-property-performance relationship of a designed steel mega-sub controlled structural system (MSCSS) under the reported earthquake waves has been investigated through integrating the finite element simulations and the experimental validations. It can be found that the MSCSS configurations are capable of effectively optimizing the vibration responses with significantly decreased acceleration, which is also much better than the traditional megaframe structure with extra weight. Moreover, if the horizontal connections between the sub- and the megastructures are broken, the displacement of the megastructure will be smaller than that of the substructure. This is because only the vertical connections between the sub- and megastructures work, the larger displacements or the obvious response of the substructures should be caused by the extra weight of the damper on the top floor. It is worth mentioning that the formation of abrupt amplified β of the top floors should be attributed to the sheath effect. Furthermore, the displacement of the substructure is one kind of energy dissipation. Its larger displacement will result in a greater amount of energy dissipation and better performance of the designed configuration. This work supports a digital twin assistant active design and optimization strategy to further improve the control effectiveness of the system and to enhance the mechanical performance of the optimized configuration of MSCSS.Polyphenylene sulfones (PPSU) blends with different viscosities have been studied. It is shown that the blends have a single-phase structure, regardless of the viscosities of the mixed polymers. It was found that blends having close values of the melt flow index (MFR) are also characterized by a similar melt viscosity in a wide range of shear rates, regardless of the viscosities of its constituent components. It has been found that PPSU blends with smaller MFR differences exhibit higher heat resistance and stability of mechanical properties, while blends with similar viscosity containing oligomers exhibit a broader molecular weight distribution (MWD) and have lower thermal and mechanical properties.This study aimed to investigate the interaction parameters of antioxidant molecules in some spices and vegetables with gamma radiation. At first, mass attenuation coefficients (MACs, cm2/g) of gingerol, rosmarinic acid, quercetin, curcumin, eugenol, piperine, allicin, and capsaicin molecules were determined at the photon energies (13-1332 keV) emitted from the radioactive isotopes Am-241, Ba-133, Co-60, and Cs-137 with the help of the EpiXS and WinXCOM programs. The smallest and largest MAC values were found as 1.20 and 8.48 cm2/g at 13 keV and 0.059 and 0.058 cm2/g at 1332 keV for eugenol and allicin, respectively. It was observed that both results support each other. Using the MAC values, the effective atomic number and electron density (Zeff and Neff) values of the molecules were derived. The Zeff values for gingerol and allicin were obtained in the range of 5.79-3.40 and 13.85-4.53, respectively. The variation of the buildup factors of antioxidants in the range of 0.015-15 MeV depending on the chemical composition and penetration depth were also examined. It was noticed that the photon accumulation was the lowest in allicin and the highest in gingerol and eugenol. The results obtained from this study will make an essential contribution to dose calculations in food irradiation studies.The aim of this study was to determine the mechanical properties of laminated beams containing selected wood species in the tension zone using a four-point bending test. Three beam types were manufactured with respect to the timber used in the tension zone, i.e., beams containing oak or beech timber of I and II quality class and pine timber with no defects (as defects had been removed). The manufactured beams were assessed with respect to bending strength and the modulus of elasticity. The obtained results were compared with the performance of BSH (Industrial beams GL made in Germany-Brettschichtholz) industrial beams. We concluded that beams made from pine timber are an appropriate alternative to spruce beams. The static bending strength of the beams made with hardwood faces was 70% higher than that of beams made with pine wood. All types of beams manufactured in the laboratory met the requirements of at least the GL24c class.The aim of this study is to assess the stress distribution on the bone tissue and bone-implant interface of a customized anatomic root-analog dental implant (RAI) by means of finite element analysis (FEA) for different types of bone density. A mandibular right second premolar was selected from the CBCT database. A DICOM file was converted to an STL file to create a CAD model in FEA software. https://www.selleckchem.com/products/cfse.html The bone boundary model was created, while bone density types I-IV were determined. Von Mises stress was measured at bone tissues and bone-implant interfaces. To validate the models, the RAI was 3D printed through a laser powder-bed fusion (L-PBF) approach. The results revealed that all RAI designs could not cause plastic deformation or fracture resulting in lower stress than the ultimate tensile stress of natural bone and implant. Compared to a conventional screw-type implant, RAIs possess a more favorable stress distribution pattern around the bone tissue and the bone-implant interface. The presence of a porous structure was found to reduce the stress at cancellous bone in type IV bone density.In order to explore the effect of the foaming agent type on the properties of foamed mixture lightweight soil mixed with bauxite tailings (FMLSB), low-density (437.5 kg/m3 and 670 kg/m3) and high-density (902.5 kg/m3 and 1170 kg/m3) FMLSB were prepared using protein-based and synthetic-based foaming agents (AF and SF, respectively). The foam stability, micro characteristics, compressive strength, fluidity, and volume of water absorption of the FMLSB were investigated. The results showed that the foam made from AF had better strength and stability compared to SF. The internal pore sizes of both AF- and SF-FMLSB at low density were large, but at high density the internal pore sizes and area porosity of AF-FMLSB were smaller than those of SF-FMLSB. In terms of compressive strength, the compressive strength of AF-FMLSB was improved by 17.5% to 43.2% compared to SF-FMLSB. At low density, the fluidity of AF- and SF-FMLSB is similar, while at high density the fluidity of AF-FMLSB is much higher than that of SF-FMLSB. In addition, the stable volume of water absorption of SF-FMLSB is smaller than that of AF-FMLSB at low density, and the corresponding water resistance is better, but the situation is reversed at high density.Significant efforts have been made to improve adsorbents capable of eliminating pollutants from aqueous solutions, making it simple and quick to separate from the treated solution. In the current study, the removal of Crystal Violet Dye (CVD) from an aqueous synthetic solution onto a marine diatom alga, Skeletonema costatum, was investigated. Different experiments were conducted as a function of different pH, contact time, adsorbent dosage, temperature, and initial CVD concentration. The highest adsorption efficiency (98%) was obtained at 0.4 g of S. costatum, pH 3, and a contact time of 120 min, at 25 °C. Furthermore, Fourier-transform infrared spectroscopy (FTIR) results display that binding of CVD on S. costatum may occur by electrostatic and complexation reactions. Moreover, the Brunauer-Emmett-Teller surface area analysis (BET) obtained was 87.17 m2 g-1, which, in addition to a scanning electron microscope (SEM), reveals large pores that could enhance the uptake of large molecules. However, the equilibrium adsorption models were conducted by Halsey, Langmuir, Freundlich, Henderson, and Tempkin isotherm. In addition, multilayer adsorption isotherm best described the uptake of CVD onto S. costatum. The maximum monolayer adsorption capacity (qmax) was 6.410 mg g-1. Moreover, thermodynamic parameters of the adsorption studies suggested that the uptake of CVD onto S. costatum was endothermic and spontaneous. The pseudo-first-order, pseudo-second-order, and intra-particle diffusion kinetic equations were applied to model the adsorption kinetic data. It was seen that the kinetics of the adsorption may be described using pseudo-second-order kinetic equations. Finally, the present work concluded that the marine diatom alga S. costatum is suitable as a natural material for the adsorption of CVD.The research and development of rocket propellants with a high solid content and superior mechanical and security performance is urgently needed. In this paper, a novel extruded modified double-base (EMDB) rocket propellant plasticized by N-butyl-N-nitratoethyl nitramine (Bu-NENA) was prepared to overcome this challenge. The results indicated that Bu-NENA decreased the mechanical sensitivity successfully, contributing to the mechanical properties against traditional nitroglycerin (NG) based EMDB propellants, while hexogen (RDX), which is beneficial to propellant energy, was not conducive to the elongation and sensitivity of the propellants. By contrast with the blank group (NG-based EMDB propellant, R0), the elongation of the optimized propellant at -40 °C was promoted by 100% from 3.54% to 7.09%. Moreover, the β-transition temperature decreased from -33.8 °C to -38.1 °C due to superior plasticization by Bu-NENA, which represents a better toughness. The friction sensitivity dropped by 100% from 46% to 0%. Simultaneously, the height for 50% probability of explosion (H50) increased by 87.2% from 17.2 cm to 32.2 cm. The results of this research could be used to predict a potential prospect in tactical weapons.Hydrogen fuel cells have been used worldwide due to their high energy density and zero emissions. The metallic bipolar plate is the crucial component and has a significant effect on a cell's efficiency. However, the springback behavior of the metallic bipolar plate will greatly influence its forming accuracy in the micro-scale sheet metal forming process. Therefore, accurate calculation of the springback angle of the micro-scale metallic bipolar plate is urgent but difficult given the state of existing elastoplastic theory. In this paper, a constitutive model that simultaneously considers grain size effect and strain gradient is proposed to analyze micro-scale bending behavior and calculate springback angles. The specialized micro-scale four-point bending tool was designed to better calculate the springback angle and simplify the calculation step. A pure micro-bending experiment on a 316LN stainless steel sheet with a thickness of 0.1 mm was conducted to verify the constitutive model's accuracy.In the pressurized water reactor nuclear power plant, 316L SS chips were captured by the support grid and continued to affect the Zr-4 cladding tube, causing the fuel rods to wear and perforate. In this work, a 60° acute angle cone of 316L SS was used to simulate the cyclic impact of debris on a Zr-4 alloy tube with different initial impact velocities and impact angles. Results showed that increasing the initial impact velocity will generate a wear debris accumulation layer with a wear-reducing effect, but also promote the extension and expansion of fatigue cracks, resulting in the delamination of Zr-4 alloy tubes. The inclination of the impact angle increases the energy loss. The energy loss rate of the 45° impact is as high as 69.68%, of which 78% is generated by the impact-sliding stage. The normal force is mainly responsible for the wear removal and plastic deformation of Zr-4 alloy tubes. Tangential forces cause severe cutting in Zr-4 alloys and pushes the resulting wear debris away from the contact surfaces.

The superior performance of the proposed method was confirmed by the high correlation coefficient of 0.8075 (p less then 0.0001) of the BMD measured by DXA in a total of 150 testing cases, with only 0.12 s required for applying the computing configuration to a single X-ray image.Anterior knee pain is a commonly documented musculoskeletal disorder among badminton players. However, current biomechanical studies of badminton lunges mainly report kinetic profiles in the lower extremity with few investigations of in-vivo loadings. The objective of this study was to evaluate tissue loadings in the patellofemoral joint via musculoskeletal modelling and Finite Element simulation. The collected marker trajectories, ground reaction force and muscle activation data were used for musculoskeletal modelling to compute knee joint angles and quadricep muscle forces. These parameters were then set as boundary conditions and loads for a quasistatic simulation using the Abaqus Explicit solver. https://www.selleckchem.com/products/vt103.html Simulations revealed that the left-forward (LF) and backward lunges showed greater contact pressure (14.98-29.61%) and von Mises stress (14.17-32.02%) than the right-forward and backward lunges; while, loadings in the left-backward lunge were greater than the left-forward lunge by 13-14%. Specifically, the stress in the chondral layer was greater than the contact interface, particularly in the patellar cartilage. These findings suggest that right-side dominant badminton players load higher in the right patellofemoral joint during left-side (backhand) lunges. Knowledge of these tissue loadings may provide implications for the training of badminton footwork, such as musculature development, to reduce cartilage loading accumulation, and prevent anterior knee pain.This article presents the results of the development and study of an ultrasonic radiator (US radiator) of increased power, which is designed for control, location, cavitation processing of liquids, and coagulation of foreign particles in a gaseous media at frequencies from 30 to 90 kHz. The proposed method of vibration summing of low-power high-frequency Langevin transducers on a diametrically vibrating the summing radiating element (summator) allowed developing such a US radiator. The selecting of shape and the search of optimal dimensions allowed creating real designs of US radiator with operating frequency up to 90 kHz. It can generate exposure intensity of 45 W/cm2 at the US radiator power up to 1900 W and an operating frequency of 30 kHz or exposure intensity of 34.6 W/cm2 at the US radiator power up to 270 W and an operating frequency of 90 kHz at cavitational processing of liquids.Time-effective, unsupervised clustering techniques are exploited to discriminate nanometric metal disks patterned on a dielectric substrate. The discrimination relies on cluster analysis applied to time-resolved optical traces obtained from thermo-acoustic microscopy based on asynchronous optical sampling. The analysis aims to recognize similarities among nanopatterned disks and to cluster them accordingly. Each cluster is characterized by a fingerprint time-resolved trace, synthesizing the common features of the thermo-acoustics response of the composing elements. The protocol is robust and widely applicable, not relying on any specific knowledge of the physical mechanisms involved. The present route constitutes an alternative diagnostic tool for on-chip non-destructive testing of individual nano-objects.
Focal cortical dysplasias (FCDs) represent one of the most frequent causes of pharmaco-resistant focal epilepsies. Despite improved clinical imaging methods over the past years, FCD detection remains challenging, as FCDs vary in location, size, and shape and commonly blend into surrounding tissues without clear definable boundaries. We developed a novel convolutional neural network for FCD detection and segmentation and validated it prospectively on daily-routine MRIs.

The neural network was trained on 201 T1 and FLAIR 3 T MRI volume sequences of 158 patients with mainly FCDs, regardless of type, and 7 focal PMG. Non-FCD/PMG MRIs, drawn from 100 normal MRIs and 50 MRIs with non-FCD/PMG pathologies, were added to the training. We applied the algorithm prospectively on 100 consecutive MRIs of patients with focal epilepsy from daily clinical practice. The results were compared with corresponding neuroradiological reports and morphometric MRI analyses evaluated by an experienced epileptologist.

Best trainin developed a 3D convolutional neural network with autoencoder regularization for FCD detection and segmentation. Our algorithm employs the largest FCD training dataset to date with various types of FCDs and some focal PMG. It provided a higher sensitivity in detecting FCDs than conventional visual analyses. Despite its low specificity, the number of false positively predicted lesions per MRI was lower than with morphometric analysis. We consider our algorithm already useful for FCD pre-screening in everyday clinical practice.It is highly tempting to develop high-efficacy targeted nanotherapeutics based on FDA approved polymers like PLGA. Herein, we describe facile fabrication of robust, hyaluronic acid-surfaced and disulfide-crosslinked star-PLGA nanoparticles (HA-sPLGA XNPs) for targeted and reduction-triggered release of docetaxel (DTX), achieving markedly enhanced treatment of A549 lung tumor in vivo. HA-sPLGA XNPs carrying 5.2 wt.% DTX (DTX-HA-sPLGA XNPs) had a size of 105.5 ± 0.5 nm and great stability while almost completely released DTX under 10 mM glutathione. Confocal and flow cytometry experiments revealed fast cellular uptake of HA-sPLGA XNPs by CD44-overexpressing A549 cells. DTX-HA-sPLGA XNPs held much higher potency to A549 cells than DTX-loaded HA-surfaced and non-crosslinked star-PLGA nanoparticles (DTX-HA-sPLGA NPs), DTX-loaded HA-surfaced and non-crosslinked linear-PLGA nanoparticles (DTX-HA-lPLGA NPs), and free DTX (IC50 = 0.18 versus 0.38, 1.21 and 0.83 µg DTX equiv./mL). Intriguingly, DTX-HA-sPLGA XNPs revealnical translation. Here, we developed hyaluronic acid-surfaced and disulfide-crosslinked star-PLGA nanoparticles (HA-sPLGA XNPs) that enabled stable encapsulation and targeted delivery of docetaxel (DTX) to CD44+ A549 lung cancer cells in vitro and in vivo, affording markedly improved tumor accumulation and repression and lower side effects compared with free DTX control. Importantly, HA-sPLGA XNPs are based on fully biocompatible materials and comparably simple to fabricate. The evident tumor targetability and safety makes HA-sPLGA XNPs a unique and potentially translatable platform for chemotherapy of CD44+ cancers.

The simulation results indicate that the lateral intermediate zone-the head and neck of the mandible-and the articular eminence sustained the most significant stresses during the mouth opening motion. The results also suggested that the stresses increase as the range of opening increases with the greatest von Mises stress, tensile, and compressive stress found at the position of maximal opening.The reduction of (nBu3P)AgCl with LBH(sec-Bu)3 in toluene gives the metalloid silver cluster Ag64(PnBu3)16Cl61 as dark red, temperature and light sensitive single crystals in high yield. 1 is the largest structurally characterized metalloid silver cluster exhibiting chlorine and phosphine substituents only. The silver atoms in 1 show an overall brick-shape arrangement, where structural resemblance to the close packed fcc- and hcp-structures is realized. Within 1 a 58 electron closed shell system is present. The light sensitivity renders 1 as a model compound for the primary seeds of the photo process, whereby this sensitivity, together with the high-yield synthesis show that 1 is a perfect starting compound for further investigations like silver covering processes.Thyroid hormones (TH) are key regulators of bone health, and TH excess in mice causes high bone turnover-mediated bone loss. However, the underlying molecular mechanisms of TH actions on bone remain poorly defined. Here, we tested the hypothesis whether TH mediate their effects via the pro-osteogenic bone morphogenetic protein (BMP) signaling pathway in vitro and in vivo. Primary murine osteoblasts treated with 3,3',5-triiodo-L-thyronine (T3 ) showed an enhanced differentiation potential, which was associated with activated canonical BMP/SMAD signaling reflected by SMAD1/5/8 phosphorylation. Blocking BMP signaling at the receptor (LDN193189) and ligand level (noggin, anti-BMP2/BMP4 neutralizing antibodies) inhibited T3 -induced osteogenic differentiation. In vivo, TH excess over 4 weeks in male C57BL/6JRj mice led to severe trabecular bone loss with a high bone turnover that was completely prevented by treatment with the BMP ligand scavenger ALK3-Fc. Thus, TH activate the canonical BMP pathway in osteoblasts to promote their differentiation and function. Importantly, this study indicates that blocking the BMP pathway may be an effective strategy to treat hyperthyroidism-induced bone loss. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.We have designed and synthesized a novel molecular hybrid in which acridine orange (AO) is covalently linked to an N-nitrosoaniline derivative through an alkyl spacer. Photoexcitation of the AO antenna with the highly biocompatible green light results in intense fluorescence emission and triggers the NO detachment from the N-nitroso appendage via an intramolecular electron transfer. The presence of the AO moiety encourages the binding with DNA through both external and partially intercalative fashions, depending on the DNAmolecular hybrid molar ratio. Importantly, this dual-mode binding interaction with the biopolymer does not preclude the NO photoreleasing performances of the molecular hybrid, permitting NO to be photogenerated nearby DNA with an efficiency similar to that of the free molecule. These properties make the presented compound an intriguing candidate for fundamental and potential applicative research studies where NO delivery in the DNA proximity precisely regulated by the harmless green light is required.Metal nanoclusters (NCs) have a particle size of about one nanometer, which makes them the smallest unit that can give a function to a substance. In addition, metal NCs possess physical and chemical properties that are different from those of corresponding bulk metals. Metal NCs with such characteristics are expected to be important for use in nanotechnology. Research on the precise synthesis of metal NCs and elucidation of their physical/chemical properties and functions is being actively conducted. When metal NCs are alloyed, it is possible to obtain further various electronic and geometrical structures and functions. Thus, research on alloy NCs has become a hot topic in the study of metal NCs and the number of publications on alloy NCs has increased explosively in recent years. Such publications have provided much insight into the effects of alloying on the electronic structure and function of metal NCs. However, the rapid increase in knowledge has made it difficult for researchers (especially those new to the field) to grasp all of it. Therefore, in this review, we summarize the reported chemical composition, geometrical structure, electronic structure, and physical and chemical properties of Au n-x M x (SR) m , Ag n-x M x (SR) m , Au n-x M x (PR 3 ) l (SR) m , and Ag n-x M x (PR 3 ) l (SR) m (Au = gold, Ag = silver, M = heteroatom, PR 3 = phosphine, and SR = thiolate) NCs. https://www.selleckchem.com/Androgen-Receptor.html This review is expected to help researchers understand the characteristics of alloy NCs and lead to clear design guidelines to develop new alloy NCs with intended functions.Background Remote magnetic navigation (RMN)-guided ablation has become an inspiring method of catheter ablation for tachyarrhythmias. Hypothesis Data from a large-scale single center may provide further insight into the safety of and the learning curve for RMN-guided ablation. Methods A total of 1003 catheter ablation procedures using RMN for conditions including supraventricular ventricular tachycardia, atrial tachyarrhythmias, and premature ventricular contraction/ventricular tachycardia (PVC/VT) were retrospectively analyzed from an ablation registry. Procedural outcomes, including procedure time, mapping time, X-ray time, and RF time, were assessed. The complications were classified into two categories major and minor. A subanalysis was used to illustrate the learning curve of RMN-guided ablation by assessing procedure time and total X-ray time of 502 atrial fibrillation (AF) ablation procedures. Results Among these procedures, 556 (55.4%) were AF and 290 (28.9%) were PVC/VT. Electrical pulmonary vein isolation was achieved in 99.0% of AF procedures, and acute success reached 90.3% in PVC/VT procedures. The overall complication rate was 0.5%. In the subanalysis of AF procedures, the overall procedure time and X-ray time of procedures were short (125.9 ± 54.6 and 5.3 ± 3.9 minutes, respectively) and proceeded to decrease from the initial 30 procedures to about 300 procedures, where the learning curve reached plateau, demonstrating maximum procedure efficiency. Conclusions RMN-guided ablation is safe, as verified by very low overall complication rate and reduced X-ray time. In our study, even the first AF procedures had a relatively low procedure time and total X-ray time, and procedure efficiency improved during the learning curve.

e. Beck Youth Inventories, Social Skills Improvement System, Child and Adolescent Functional Assessment Scale, Child Behavior Checklist, Brief Child and Family Phone Interview). Overall, the externalizing subscale demonstrated strong measurement properties for the assessment of behavioral disturbances.Skin injury is a major problem threatening human physical and mental health, and how to promote wound healing has been the focus. Developing new wound dressings is an important strategy in skin regeneration. Aloe vera is a medicinal plant with a long history, complex constituents, and various pharmacological activities. Many studies have shown that A. vera plays an important role in promoting wound healing. Adding A. vera to wound dressing has become an ideal way. This review will describe the process of skin injury and wound healing and analyze the role of A. vera in wound healing. In addition, the types of wound dressing and the applications of A. vera in wound dressing will be discussed.Objective The incidence of severe infectious complications after burn injury increases mortality by 40%. However, traditional approaches for managing burn infections are not always effective. High-voltage, pulsed electric field (PEF) treatment shortly after a burn injury has demonstrated an antimicrobial effect in vivo; however, the working parameters and long-term effects of PEF treatment have not yet been investigated. https://www.selleckchem.com/products/17-AAG(Geldanamycin).html Approach Nine sets of PEF parameters were investigated to optimize the applied voltage, pulse duration, and frequency or pulse repetition for disinfection of Pseudomonas aeruginosa infection in a stable mouse burn wound model. The bacterial load after PEF administration was monitored for 3 days through bioluminescence imaging. Histological assessments and inflammation response analyses were performed at 1 and 24 h after the therapy. Results Among all tested PEF parameters, the best disinfection efficacy of P. aeruginosa infection was achieved with a combination of 500 V, 100 μs, and 200 pulserapy for P. aeruginosa burn infections.Immune non-responders (INRs) are people with HIV infection who fail to restore their CD4 T-cell counts in spite of prolonged virologic suppression, a condition associated with higher rates of all-cause mortality. The mechanisms of immune non-response are not entirely clear. We used existing clinical and genetic data from AIDS Clinical Trials Group clinical trials to ask whether an IFNL4 single-nucleotide polymorphism, shown to be associated with outcomes for other infectious diseases, correlated with immune non-response for HIV. Analysis of data from 426 participants with clearly defined CD4 T-cell recovery phenotypes, including 88 INRs with CD4  less then  200 cells/mm3 after 2 years of suppressive antiretroviral therapy, did not identify an association of IFNL4 genotype with immune non-response. Thus, the IFNL4 genotype is unlikely to influence immunologic recovery.Aims Catecholamine metabolism via monoamine oxidase (MAO) contributes to cardiac injury in models of ischemia and diabetes, but the pathogenic mechanisms involved are unclear. MAO deaminates norepinephrine (NE) and dopamine to produce H2O2 and highly reactive "catecholaldehydes," which may be toxic to mitochondria due to the localization of MAO to the outer mitochondrial membrane. We performed a comprehensive analysis of catecholamine metabolism and its impact on mitochondrial energetics in atrial myocardium obtained from patients with and without type 2 diabetes. Results Content and maximal activity of MAO-A and MAO-B were higher in the myocardium of patients with diabetes and they were associated with body mass index. Metabolomic analysis of atrial tissue from these patients showed decreased catecholamine levels in the myocardium, supporting an increased flux through MAOs. Catecholaldehyde-modified protein adducts were more abundant in myocardial tissue extracts from patients with diabetes and were confirmed to be MAO dependent. NE treatment suppressed mitochondrial ATP production in permeabilized myofibers from patients with diabetes in an MAO-dependent manner. Aldehyde dehydrogenase (ALDH) activity was substantially decreased in atrial myocardium from these patients, and metabolomics confirmed lower levels of ALDH-catalyzed catecholamine metabolites. Proteomic analysis of catechol-modified proteins in isolated cardiac mitochondria from these patients identified >300 mitochondrial proteins to be potential targets of these unique carbonyls. Innovation and Conclusion These findings illustrate a unique form of carbonyl toxicity driven by MAO-mediated metabolism of catecholamines, and they reveal pathogenic factors underlying cardiometabolic disease. Importantly, they suggest that pharmacotherapies targeting aldehyde stress and catecholamine metabolism in heart may be beneficial in patients with diabetes and cardiac disease.Non-human primate (NHP) models are the closest approximation of human spinal cord injury (SCI) available for pre-clinical trials. The NHP models, however, include broader morphological variability that can confound experimental outcomes. We developed subject-specific finite element (FE) models to quantify the relationship between impact mechanics and SCI, including the correlations between FE outcomes and tissue damage. Subject-specific models of cervical unilateral contusion SCI were generated from pre-injury MRIs of six NHPs. Stress and strain outcomes were compared with lesion histology using logit analysis. A parallel generic model was constructed to compare the outcomes of subject-specific and generic models. The FE outcomes were correlated more strongly with gray matter damage (0.29 less then R2 less then 0.76) than white matter (0.18 less then R2 less then 0.58). Maximum/minimum principal strain, Von-Mises and Tresca stresses showed the strongest correlations (0.31 less then R2 less then 0.76) with tissue damage in the gray matter while minimum principal strain, Von-Mises stress, and Tresca stress best predicted white matter damage (0.23 less then R2 less then 0.58). Tissue damage thresholds varied for each subject. The generic FE model captured the impact biomechanics in two of the four models; however, the correlations between FE outcomes and tissue damage were weaker than the subject-specific models (gray matter [0.25 less then R2 less then 0.69] and white matter [R2 less then 0.06] except for one subject [0.26 less then R2 less then 0.48]). The FE mechanical outputs correlated with tissue damage in spinal cord white and gray matters, and the subject-specific models accurately mimicked the biomechanics of NHP cervical contusion impacts.