People

Sorry, no results were found.

Circles

Sorry, no results were found.

Posts

01/28/2025


Electrocatalytic oxygen reduction reaction (ORR) provides an attractive alternative to anthraquinone process for H2O2 synthesis. Rational design of earth-abundant electrocatalysts for H2O2 synthesis via a two-electron ORR process in acids is attractive but still very challenging. In this work, we report that nitrogen-doped carbon nanotubes as a multi-functional support for CoSe2 nanoparticles not only keep CoSe2 nanoparticles well dispersed but alter the crystal structure, which in turn improves the overall catalytic behaviors and thereby renders high O2-to-H2O2 conversion efficiency. In 0.1 M HClO4, such CoSe2@NCNTs hybrid delivers a high H2O2 selectivity of 93.2% and a large H2O2 yield rate of 172 ppm·h-1 with excellent durability up to 24 h. Moreover, CoSe2@NCNTs performs effectively for organic dye degradation via electro-Fenton process.
Supplementary material (SEM images, EDX mapping images, XPS spectrum, XRD patterns, RRDE voltammogram, Tafel plots, cyclic voltammograms, UV-Vis spectra, and Tables S1) is available in the online version of this article at 10.1007/s12274-021-3474-0.
Supplementary material (SEM images, EDX mapping images, XPS spectrum, XRD patterns, RRDE voltammogram, Tafel plots, cyclic voltammograms, UV-Vis spectra, and Tables S1) is available in the online version of this article at 10.1007/s12274-021-3474-0.Increasing food production by developing small-scale irrigation schemes is a requirement for tackling household food insecurity. Strategies, such as the World Vision, Enhancing Nutrition, Stepping Up Resilience and Enterprise, have been established to enhance food availability in the drought-prone Burirano Ward 4, Chipinge, Zimbabwe, through the drip irrigation intervention. This study analysed the extent to which the drip intervention has increased food production, abilities, income and nutrition of households. Consequently, the key factors impacting the performance of the drip irrigation scheme were assessed. The study utilised a mixed-method convergent parallel design, drawing from semi-structured questionnaires administered on a census of 40 household beneficiaries as well as a focus group discussion of five key informants directly linked to the Chidzadza irrigation scheme, Burirano Ward 4, Chipinge, Zimbabwe. The findings show that the drip irrigation scheme significantly increased households' food production abilities, nutrition and income. The main factors responsible for the success of the drip irrigation scheme are cheap labour from household members and agriculture extension support. Issues that prevent the success of the scheme include erratic rain supplies and damaged water pipes. Strategies to increase household food production through the drip irrigation scheme include maintenance of water pipes, an increase in water catchment areas and water availability through solar-powered borehole systems.Food insecurity has increasingly become a topical issue that needs to be addressed before it goes out of hand. The article explores the synergistic relationship that exists between Amartya Sen entitlement and systems theories. The article hypothesises that food insecurity in Matabeleland South Province is mainly caused by a lack of understanding of food security pillars and how all the concepts dove tail into the food security discourse. The article further propounds that, for communities to go out of the food insecurity quagmire, they need to work collaboratively as a system as substantiated by the systems theory. Sen argues that the law stands between food availability and access. This is further simplified as follows food can be available in the markets but the people might lack the purchasing power to purchase the food. When people try to acquire food through stealing, the law catches on them. On the other hand, the systems theory argues that for a community to function well all the parts should play their roles towards the survival of the whole. The theory further informs that government stakeholders and non-state actors must work together in addressing food insecurity without a clearly defined direction. Interactions with provincial stakeholders, revealed that, a leaf can be borrowed and applied from the two theoretical models to achieve food security in Matabeleland South Province in Zimbabwe.The Igbo people survived a civil war that raged between 1967 and 1970 and that devastated their land and reduced their population because of more than three million deaths. They were confronted with the challenges of beginning life afresh from scratch with almost nothing. Since then, they have allegedly been marginalised on a continuous basis by the Nigerian government. This notwithstanding the people with their communal spirit, which saw them through the civil war, have continued to cement their survival resolve in the post-war era. The aim of this article was to study the Igbo communal system as the bedrock of Igbo progress, especially in the past 50 years and recommends it as the basic principle of Igbo survival in Nigeria. It considers Igbo communal spirit as a veritable panacea against the recent agitations for secession by the people as that would guarantee Igbo people an ample space to operate in Nigeria. The methodology used in this article is a qualitative phenomenological method. This was carried out by interviewing some members of Igbo society, observing and interpreting events in Igbo society and as documented in literatures. It was found that Igbo people have really done well for themselves despite the seeming marginalisation by sticking to their resilient spirit. This study concluded that instead of seeking for independence from Nigeria, the Igbo people need to be mindful of their resilient communal spirit and reinforce it in all spheres of life. This would make them more relevant in the country's affairs than they are currently.The body characteristics and yield indices of Clarias gariepinus, Bagrus bajad, Synodontis nigrita, Labeo senegalensis and Mormyrus rume from lower Benue River in Nigeria were determined in this study using 60 samples each for the fish species. Length, weight and fillet correlations were also determined during the study. https://www.selleckchem.com/products/k03861.html Results obtained showed that M. rume, L. senegalensis and C. gariepinus had the highest percentage of edible parts (≥ 55%) compared to the other species (≤ 39%). Concerning correlations of the fillet with the morphological variables, results obtained suggest that fillet yield is independent of fish size (except for C. gariepinus which was positively correlated). Also, only samples of L. senegalensis showed isometric growth pattern; the other fish species had either positive (C. gariepinus and B. bajad) or negative (S. nigrita and M. rume) allometric growth. While the difference in fillet yield and body characteristics was attributed to the structural anatomy and other biological dynamics of the fishes, this study could not establish a connection between fillet yield and the length-weight relationship.

01/16/2025

CALIFORNIA END OF DAYS: Five scenarios of collapse, secession, revolution or reform

https://www.brighteon.com/b1e1b1f1-4469-4f59-9b79-7ffe5929ef69

- California's Current Crisis and Corruption (0:00)- Public Disgust with California Leadership (2:05)- The Criminal Cabal and Election Fraud (4:07)- Democrats' Incapability to Govern (6:37)- Potential Outcomes for California (9:20)- Military Coup and Deportation Enforcement (14:56)- Possible Split of California (26:07)- Spiritual and Moral Issues in California (34:49)- Support for California and Call to Action (41:05)- Introduction of Gold Backs for Florida (46:03)For more updates, visit: http://www.brighteon.com/channel/hrreport NaturalNews videos would not be possible without you, as always we remain passionately dedicated to our mission of educating people all over the world on the subject of natural healing remedies and personal liberty (food freedom, medical freedom, the freedom of speech, etc.). Together, we’re helping create a better world, with more honest food labeling, reduced chemical contamination, the avoidance of toxic heavy metals and vastly increased scientific transparency.▶️ Every dollar you spend at the Health Ranger Store goes toward helping us achieve important science and content goals for humanity: https://www.healthrangerstore.com/ ▶️ Sign Up For Our Newsletter: https://www.naturalnews.com/Readerregistration.html ▶️ Brighteon: https://www.brighteon.com/channels/hrreport ▶️ Join Our Social Network: https://brighteon.social/@HealthRanger ▶️ Check In Stock Products at: https://PrepWithMike.com 🔴 Brighteon.io: Brighteon.io/HealthRanger🔴 Brighteon.Social: https://brighteon.social/@HealthRanger 🔴 Gettr: https://gettr.com/user/naturalnews 🔴 Gab: https://gab.com/NaturalNews 🔴 Bitchute: https://www.bitchute.com/channel/naturalnews 🔴 Rumble: https://rumble.com/c/HealthRangerReport 🔴 Mewe: https://mewe.com/p/naturalnews 🔴 Spreely: https://social.spreely.com/NaturalNews 🔴 Telegram: https://t.me/naturalnewsofficial 🔴 Pinterest: https://www.pinterest.com/realhealthrangerstore/

www.brighteon.com

12/31/2024


Orbital metastasis from breast cancer is relatively uncommon and is not the dominant prognosis. While it can reduce a patient's QOL through symptoms such as diplopia, visual impairment, and exophthalmos, evidence suggests that radiotherapy might improve these symptoms in a relatively short period. We report 3 cases of orbital metastasis from breast cancer treated with radiotherapy. All 3 patients were diagnosed with stage Ⅳ breast cancer and underwent chemotherapy and endocrine therapy for several years. When they were diagnosed with orbital metastasis, their life expectancy was only a few months with debilitating illness. They received radiotherapy, which caused slight side effects including skin disorders. The cancer symptoms rapidly improved in 2 patients, suggesting that radiotherapy can be an efficacious choice for improving the QOL for patients with orbital metastasis from breast cancer, especially for patients in terminal status.A 72-year-old woman was admitted to our hospital because of symptoms of bleeding diathesis such as hematuria and purpura. https://www.selleckchem.com/products/dsp5336.html A blood test revealed disseminated intravascular coagulation(DIC). Upper gastrointestinal endoscopy showed advanced gastric cancer. Bone marrow aspiration cytology demonstrated diffuse hyperplasia of large atypical cells, and metastasis of the epithelial tumor was suspected on immunohistochemical examination. She was diagnosed with disseminated carcinomatosis of the bone marrow associated with gastric cancer accompanied by DIC. She was treated with weekly infusion of methotrexate 100 mg/m2 plus 5-fluorouracil 600 mg/m2 for 4 courses; and she completely recovered from DIC. She received oral tegafur/gimeracil/oteracil as an outpatient. However, DIC recurred 126 days after the initial chemotherapy, and 5-fluorouracil plus cisplatin was administered subsequently. After 1 course, she died 166 days after the initial chemotherapy. Although the prognosis of patients with disseminated carcinomatosis of the bone marrow associated with gastric cancer accompanied by DIC is extremely poor, this case shows that secession of DIC and prognostic improvement by chemotherapy could occur. Chemotherapy could be considered a potentially effective treatment in this case.A 61-year-old woman, who consulted another doctor with chief complaints of epigastric pain, nausea, anorexia, palpitation, and shortness of breath since a month was referred to our hospital for diagnosis and treatment. She was diagnosed with advanced gastric cancer. She was also found to have severe anemia(hemoglobin 1.8 g/dL)and malnutrition. With adequate precautions to prevent development of heart failure and refeeding syndrome, the patient was treated for anemia with blood transfusion and intravenous iron injection; and for malnutrition with intravenous hyperalimentation and enteral nutrition. The patient underwent distal gastrectomy 17 days after admission. Histological examination revealed a type 3 moderately differentiated tubular adenocarcinoma>solid type of poorly differentiated adenocarcinoma>mucinous adenocarcinoma corresponding to pT4a, pN3a, pStage ⅢB, respectively. The postoperative course was good and adjuvant chemotherapy was started 22 days after surgery. However, the patient died approximately 15 months after surgery due to metastases of gastric cancer to the lymph nodes.
To evaluate the efficacy and safety of CAPOX plus bevacizumab as second-line chemotherapy for metastatic colorectal cancer.

In this multicenter phase Ⅱ study, the planned number of patients was 48, but owing to poor case accumulation, registration was discontinued for 20 patients. The primary endpoint was the response rate(RR). Secondary endpoints were progression-free survival(PFS), overall survival(OS), disease control rate(DCR), and safety.

First-line treatment was combined with irinotecan in 14 cases and bevacizumab in 12 cases. The median number of second- line treatment courses was 7, and the median treatment period was 203 days. The reason for discontinuation of treatment was disease progression in 13 cases, adverse events in 4 cases, and other reasons in 3 cases. The best response was PR in 5 cases, SD in 8 cases, and NE in 4 cases. The RR was 25%, and the DCR was 65%. The median PFS was 7.2 months, and the median OS was 18.6 months. Grade≥3 adverse events were neutropenia in 3 cases and diarrhea and peripheral neuropathy in 2 cases each. There were no treatment-related deaths.

CAPOX plus bevacizumab was a safe and effective second-line treatment option for metastatic colorectal cancer.
CAPOX plus bevacizumab was a safe and effective second-line treatment option for metastatic colorectal cancer.To the effect of chemotherapy in cancer patients, in addition to direct cytotoxicity against cancer cells, contribution of tumor immune-mediated mechanisms have been reported. To elucidate the immune environment involved in the response to chemotherapy in esophageal cancer, we collected pre-treatment biopsy tissues from 86 patients, performed multiple staining with fluorescein-labeled tyramide, and analyzed lymphocytes and macrophages using a variable-wavelength filter fluorescence microscope to compare the effects of chemotherapy. Although there was no correlation with various T-cell fractions, high levels of CD163- or CD206-positive M2 macrophages (TAM) were significantly associated with chemotherapy non-responders. The results suggest that the combination of TAM inhibitors may be useful in overcoming chemotherapy resistance in esophageal cancer.
Though irinotecan is commonly used for treating advanced gastric cancer, there is no predictive biomarker to date. We have studied the resistant mechanism for irinotecan and found that phosphorylation of serine 10 residue of topoisomerase Ⅰ(topo Ⅰ)is an important step for irinotecan resistance. We have developed an immunohistochemical staining-based biomarker; topo Ⅰ-pS10, for predicting irinotecan efficacy.

The purpose of this study is to test the accuracy of topo Ⅰ-pS10 immunohistochemical staining in gastric cancer clinical samples.

In this study we performed 2 sets of tests. In the training set, we stained 79 gastric cancer clinical samples which efficacy of irinotecan was measured by succinate dehydrogenase inhibition(SDI)test. In the validation set, we used 27 gastric cancer clinical samples which irinotecan was used and the efficacy was known.

Training set From the ROC curve the cut-off point was set at 35% positive nuclei. Sixty three cases were positive with topo Ⅰ-pS10 in the nuclei. With the result of irinotecan SDI, the sensitivity was 76.

Videos

Sorry, no results were found.

People

Sorry, no results were found.

Circles

Sorry, no results were found.

Videos

Sorry, no results were found.

Posts

01/28/2025


Electrocatalytic oxygen reduction reaction (ORR) provides an attractive alternative to anthraquinone process for H2O2 synthesis. Rational design of earth-abundant electrocatalysts for H2O2 synthesis via a two-electron ORR process in acids is attractive but still very challenging. In this work, we report that nitrogen-doped carbon nanotubes as a multi-functional support for CoSe2 nanoparticles not only keep CoSe2 nanoparticles well dispersed but alter the crystal structure, which in turn improves the overall catalytic behaviors and thereby renders high O2-to-H2O2 conversion efficiency. In 0.1 M HClO4, such CoSe2@NCNTs hybrid delivers a high H2O2 selectivity of 93.2% and a large H2O2 yield rate of 172 ppm·h-1 with excellent durability up to 24 h. Moreover, CoSe2@NCNTs performs effectively for organic dye degradation via electro-Fenton process.
Supplementary material (SEM images, EDX mapping images, XPS spectrum, XRD patterns, RRDE voltammogram, Tafel plots, cyclic voltammograms, UV-Vis spectra, and Tables S1) is available in the online version of this article at 10.1007/s12274-021-3474-0.
Supplementary material (SEM images, EDX mapping images, XPS spectrum, XRD patterns, RRDE voltammogram, Tafel plots, cyclic voltammograms, UV-Vis spectra, and Tables S1) is available in the online version of this article at 10.1007/s12274-021-3474-0.Increasing food production by developing small-scale irrigation schemes is a requirement for tackling household food insecurity. Strategies, such as the World Vision, Enhancing Nutrition, Stepping Up Resilience and Enterprise, have been established to enhance food availability in the drought-prone Burirano Ward 4, Chipinge, Zimbabwe, through the drip irrigation intervention. This study analysed the extent to which the drip intervention has increased food production, abilities, income and nutrition of households. Consequently, the key factors impacting the performance of the drip irrigation scheme were assessed. The study utilised a mixed-method convergent parallel design, drawing from semi-structured questionnaires administered on a census of 40 household beneficiaries as well as a focus group discussion of five key informants directly linked to the Chidzadza irrigation scheme, Burirano Ward 4, Chipinge, Zimbabwe. The findings show that the drip irrigation scheme significantly increased households' food production abilities, nutrition and income. The main factors responsible for the success of the drip irrigation scheme are cheap labour from household members and agriculture extension support. Issues that prevent the success of the scheme include erratic rain supplies and damaged water pipes. Strategies to increase household food production through the drip irrigation scheme include maintenance of water pipes, an increase in water catchment areas and water availability through solar-powered borehole systems.Food insecurity has increasingly become a topical issue that needs to be addressed before it goes out of hand. The article explores the synergistic relationship that exists between Amartya Sen entitlement and systems theories. The article hypothesises that food insecurity in Matabeleland South Province is mainly caused by a lack of understanding of food security pillars and how all the concepts dove tail into the food security discourse. The article further propounds that, for communities to go out of the food insecurity quagmire, they need to work collaboratively as a system as substantiated by the systems theory. Sen argues that the law stands between food availability and access. This is further simplified as follows food can be available in the markets but the people might lack the purchasing power to purchase the food. When people try to acquire food through stealing, the law catches on them. On the other hand, the systems theory argues that for a community to function well all the parts should play their roles towards the survival of the whole. The theory further informs that government stakeholders and non-state actors must work together in addressing food insecurity without a clearly defined direction. Interactions with provincial stakeholders, revealed that, a leaf can be borrowed and applied from the two theoretical models to achieve food security in Matabeleland South Province in Zimbabwe.The Igbo people survived a civil war that raged between 1967 and 1970 and that devastated their land and reduced their population because of more than three million deaths. They were confronted with the challenges of beginning life afresh from scratch with almost nothing. Since then, they have allegedly been marginalised on a continuous basis by the Nigerian government. This notwithstanding the people with their communal spirit, which saw them through the civil war, have continued to cement their survival resolve in the post-war era. The aim of this article was to study the Igbo communal system as the bedrock of Igbo progress, especially in the past 50 years and recommends it as the basic principle of Igbo survival in Nigeria. It considers Igbo communal spirit as a veritable panacea against the recent agitations for secession by the people as that would guarantee Igbo people an ample space to operate in Nigeria. The methodology used in this article is a qualitative phenomenological method. This was carried out by interviewing some members of Igbo society, observing and interpreting events in Igbo society and as documented in literatures. It was found that Igbo people have really done well for themselves despite the seeming marginalisation by sticking to their resilient spirit. This study concluded that instead of seeking for independence from Nigeria, the Igbo people need to be mindful of their resilient communal spirit and reinforce it in all spheres of life. This would make them more relevant in the country's affairs than they are currently.The body characteristics and yield indices of Clarias gariepinus, Bagrus bajad, Synodontis nigrita, Labeo senegalensis and Mormyrus rume from lower Benue River in Nigeria were determined in this study using 60 samples each for the fish species. Length, weight and fillet correlations were also determined during the study. https://www.selleckchem.com/products/k03861.html Results obtained showed that M. rume, L. senegalensis and C. gariepinus had the highest percentage of edible parts (≥ 55%) compared to the other species (≤ 39%). Concerning correlations of the fillet with the morphological variables, results obtained suggest that fillet yield is independent of fish size (except for C. gariepinus which was positively correlated). Also, only samples of L. senegalensis showed isometric growth pattern; the other fish species had either positive (C. gariepinus and B. bajad) or negative (S. nigrita and M. rume) allometric growth. While the difference in fillet yield and body characteristics was attributed to the structural anatomy and other biological dynamics of the fishes, this study could not establish a connection between fillet yield and the length-weight relationship.

01/16/2025

CALIFORNIA END OF DAYS: Five scenarios of collapse, secession, revolution or reform

https://www.brighteon.com/b1e1b1f1-4469-4f59-9b79-7ffe5929ef69

- California's Current Crisis and Corruption (0:00)- Public Disgust with California Leadership (2:05)- The Criminal Cabal and Election Fraud (4:07)- Democrats' Incapability to Govern (6:37)- Potential Outcomes for California (9:20)- Military Coup and Deportation Enforcement (14:56)- Possible Split of California (26:07)- Spiritual and Moral Issues in California (34:49)- Support for California and Call to Action (41:05)- Introduction of Gold Backs for Florida (46:03)For more updates, visit: http://www.brighteon.com/channel/hrreport NaturalNews videos would not be possible without you, as always we remain passionately dedicated to our mission of educating people all over the world on the subject of natural healing remedies and personal liberty (food freedom, medical freedom, the freedom of speech, etc.). Together, we’re helping create a better world, with more honest food labeling, reduced chemical contamination, the avoidance of toxic heavy metals and vastly increased scientific transparency.▶️ Every dollar you spend at the Health Ranger Store goes toward helping us achieve important science and content goals for humanity: https://www.healthrangerstore.com/ ▶️ Sign Up For Our Newsletter: https://www.naturalnews.com/Readerregistration.html ▶️ Brighteon: https://www.brighteon.com/channels/hrreport ▶️ Join Our Social Network: https://brighteon.social/@HealthRanger ▶️ Check In Stock Products at: https://PrepWithMike.com 🔴 Brighteon.io: Brighteon.io/HealthRanger🔴 Brighteon.Social: https://brighteon.social/@HealthRanger 🔴 Gettr: https://gettr.com/user/naturalnews 🔴 Gab: https://gab.com/NaturalNews 🔴 Bitchute: https://www.bitchute.com/channel/naturalnews 🔴 Rumble: https://rumble.com/c/HealthRangerReport 🔴 Mewe: https://mewe.com/p/naturalnews 🔴 Spreely: https://social.spreely.com/NaturalNews 🔴 Telegram: https://t.me/naturalnewsofficial 🔴 Pinterest: https://www.pinterest.com/realhealthrangerstore/

www.brighteon.com

12/31/2024


Orbital metastasis from breast cancer is relatively uncommon and is not the dominant prognosis. While it can reduce a patient's QOL through symptoms such as diplopia, visual impairment, and exophthalmos, evidence suggests that radiotherapy might improve these symptoms in a relatively short period. We report 3 cases of orbital metastasis from breast cancer treated with radiotherapy. All 3 patients were diagnosed with stage Ⅳ breast cancer and underwent chemotherapy and endocrine therapy for several years. When they were diagnosed with orbital metastasis, their life expectancy was only a few months with debilitating illness. They received radiotherapy, which caused slight side effects including skin disorders. The cancer symptoms rapidly improved in 2 patients, suggesting that radiotherapy can be an efficacious choice for improving the QOL for patients with orbital metastasis from breast cancer, especially for patients in terminal status.A 72-year-old woman was admitted to our hospital because of symptoms of bleeding diathesis such as hematuria and purpura. https://www.selleckchem.com/products/dsp5336.html A blood test revealed disseminated intravascular coagulation(DIC). Upper gastrointestinal endoscopy showed advanced gastric cancer. Bone marrow aspiration cytology demonstrated diffuse hyperplasia of large atypical cells, and metastasis of the epithelial tumor was suspected on immunohistochemical examination. She was diagnosed with disseminated carcinomatosis of the bone marrow associated with gastric cancer accompanied by DIC. She was treated with weekly infusion of methotrexate 100 mg/m2 plus 5-fluorouracil 600 mg/m2 for 4 courses; and she completely recovered from DIC. She received oral tegafur/gimeracil/oteracil as an outpatient. However, DIC recurred 126 days after the initial chemotherapy, and 5-fluorouracil plus cisplatin was administered subsequently. After 1 course, she died 166 days after the initial chemotherapy. Although the prognosis of patients with disseminated carcinomatosis of the bone marrow associated with gastric cancer accompanied by DIC is extremely poor, this case shows that secession of DIC and prognostic improvement by chemotherapy could occur. Chemotherapy could be considered a potentially effective treatment in this case.A 61-year-old woman, who consulted another doctor with chief complaints of epigastric pain, nausea, anorexia, palpitation, and shortness of breath since a month was referred to our hospital for diagnosis and treatment. She was diagnosed with advanced gastric cancer. She was also found to have severe anemia(hemoglobin 1.8 g/dL)and malnutrition. With adequate precautions to prevent development of heart failure and refeeding syndrome, the patient was treated for anemia with blood transfusion and intravenous iron injection; and for malnutrition with intravenous hyperalimentation and enteral nutrition. The patient underwent distal gastrectomy 17 days after admission. Histological examination revealed a type 3 moderately differentiated tubular adenocarcinoma>solid type of poorly differentiated adenocarcinoma>mucinous adenocarcinoma corresponding to pT4a, pN3a, pStage ⅢB, respectively. The postoperative course was good and adjuvant chemotherapy was started 22 days after surgery. However, the patient died approximately 15 months after surgery due to metastases of gastric cancer to the lymph nodes.
To evaluate the efficacy and safety of CAPOX plus bevacizumab as second-line chemotherapy for metastatic colorectal cancer.

In this multicenter phase Ⅱ study, the planned number of patients was 48, but owing to poor case accumulation, registration was discontinued for 20 patients. The primary endpoint was the response rate(RR). Secondary endpoints were progression-free survival(PFS), overall survival(OS), disease control rate(DCR), and safety.

First-line treatment was combined with irinotecan in 14 cases and bevacizumab in 12 cases. The median number of second- line treatment courses was 7, and the median treatment period was 203 days. The reason for discontinuation of treatment was disease progression in 13 cases, adverse events in 4 cases, and other reasons in 3 cases. The best response was PR in 5 cases, SD in 8 cases, and NE in 4 cases. The RR was 25%, and the DCR was 65%. The median PFS was 7.2 months, and the median OS was 18.6 months. Grade≥3 adverse events were neutropenia in 3 cases and diarrhea and peripheral neuropathy in 2 cases each. There were no treatment-related deaths.

CAPOX plus bevacizumab was a safe and effective second-line treatment option for metastatic colorectal cancer.
CAPOX plus bevacizumab was a safe and effective second-line treatment option for metastatic colorectal cancer.To the effect of chemotherapy in cancer patients, in addition to direct cytotoxicity against cancer cells, contribution of tumor immune-mediated mechanisms have been reported. To elucidate the immune environment involved in the response to chemotherapy in esophageal cancer, we collected pre-treatment biopsy tissues from 86 patients, performed multiple staining with fluorescein-labeled tyramide, and analyzed lymphocytes and macrophages using a variable-wavelength filter fluorescence microscope to compare the effects of chemotherapy. Although there was no correlation with various T-cell fractions, high levels of CD163- or CD206-positive M2 macrophages (TAM) were significantly associated with chemotherapy non-responders. The results suggest that the combination of TAM inhibitors may be useful in overcoming chemotherapy resistance in esophageal cancer.
Though irinotecan is commonly used for treating advanced gastric cancer, there is no predictive biomarker to date. We have studied the resistant mechanism for irinotecan and found that phosphorylation of serine 10 residue of topoisomerase Ⅰ(topo Ⅰ)is an important step for irinotecan resistance. We have developed an immunohistochemical staining-based biomarker; topo Ⅰ-pS10, for predicting irinotecan efficacy.

The purpose of this study is to test the accuracy of topo Ⅰ-pS10 immunohistochemical staining in gastric cancer clinical samples.

In this study we performed 2 sets of tests. In the training set, we stained 79 gastric cancer clinical samples which efficacy of irinotecan was measured by succinate dehydrogenase inhibition(SDI)test. In the validation set, we used 27 gastric cancer clinical samples which irinotecan was used and the efficacy was known.

Training set From the ROC curve the cut-off point was set at 35% positive nuclei. Sixty three cases were positive with topo Ⅰ-pS10 in the nuclei. With the result of irinotecan SDI, the sensitivity was 76.

12/28/2024


If somebody prefers to bet a soccer recreation on a 2-approach moneyline where a tie would return the original moneyline wager (like an NFL football sport), most sportsbooks have a “draw no bet” option, but they might need to dig just a little to search out it. Since aluminum is not as costly as carbon fiber, aluminum components have been capable of finding their way onto manufacturing cars a bit of faster than the costlier carbon fiber parts. The carbon dioxide and water vapor byproducts are vented by way of the chimney after which run outdoors by means of your own home chimney or side wall vent. Fill and chill the stacked layers, after which lower the cake into the shape you want, like a Christmas tree, freight practice or elephant, with a serrated knife. Sponge cake slices messily, so it is not excellent for exact dishes like petits fours. Body sliders are like roll bars for a motorcycle.

Total, the prices for season tickets varies league-vast, but Miami's packages stand as a few of the most costly in MLS at the moment -- and followers desperate to see Messi are prepared to pay for it. The 1957-58 Liga Bet season saw Hapoel Tiberias and Hapoel Ramla win their respective regional divisions. You can bet on who will win the whole tournament, or you can bet on the person matchups. A concert can come with a number of components to coordinate and endless prospects to plan forward for. A part of the rationale this franchise mannequin has worked so effectively for Marvel is that each film features a number of connections to different entries in the series, with every new installment building upon the plot of the one earlier than it. Future computers may depend on a very completely different mannequin than traditional machines. When you will follow the web sites to fetch info relating to your problem, it's possible you'll find many professionals and this could possibly be the most effective choice to follow for you. Regardless of the hazard of dealing with firearms whereas drinking, only 26 states have legal guidelines relating to using firearms whereas intoxicated. What are the authorized implications of using firearms whereas intoxicated?

The deposits are carried by the oil till they discover somewhere to settle, restricting or blocking the surrounding oil flow, which causes increased engine put on. More possible you'd find me at the keyboard of a pc, programming in languages like Fundamental and C, or writing books about why managed fusion power was the vitality supply of the long run. Meaning within the years between 2010 and 2050, computer processing power will double 20 instances if Moore's law holds true.2 gigahertz (GHz) -- the fastest commercially available processor at the moment. So whereas a discharge petition may have the ability to get a bill past an unwilling speaker or a conservative-stacked Rules Committee that would otherwise halt it, the journey would require extra time than they’re more likely to have. Some speculate it might even have the potential to finish life on Earth, while others see it as the key to unlocking the universe's deepest secrets and techniques. Making Google even higher through larger focus. JPMorgan Chase analyst Shawn Quigg instructed in a analysis word that buyers purchase stock places on CBS, which might permit the sale of CBS shares at $57.50 if the company’s inventory worth sinks attributable to declining NFL tv scores. Within the mid-2000s, Sale cofounded the Middlebury Institute to advertise the concept of secession.

National Institute on Drug Abuse (NIDA). Workplace of National Drug Management Policy (ONDCP). Centers for Illness Control and Prevention (CDC). Nationwide Cannabis Prevention and information Centre (NCPIC). McKetin, Rebecca. "The Effect of Energy Drinks on the Urge to Drink Alcohol in Young Adults." Australian National College. Nationwide Futures Affiliation. Glossary. Governors Highway Security Affiliation (GHSA). Harding, Eleanor. "Why workplace drinks are more likely to make us celebration fools than drinks with colleagues in a bar." Daily Mail. McKetin, Rebecca. "Including alcohol to power drinks leads to an increased urge to drink." EurekAlert. How does https://www.tpipay.com/ make you drunk? Some researchers suppose an ungainly association of inner organs would make that type of motion unimaginable. Right here is the prospect for you to make a difference with us! Remove your credit card data from online stores and keep your playing cards in a separate room out of your laptop or cellphone to make impulsive purchases harder. McGlynn, Katia. "21 Superior Drunk Purchases Your Sober Self Would Thank you For getting." Huffington Submit.

slot dana adalah situs judi slot dengan deposit minimal 5000 bisa juga via pulsa dengan deposit 5k mainkan sekarang juga slot murah modal receh hanya 5rb bisa jackpot maxwin.

www.tpipay.com

12/09/2024


Orbital metastasis from breast cancer is relatively uncommon and is not the dominant prognosis. While it can reduce a patient's QOL through symptoms such as diplopia, visual impairment, and exophthalmos, evidence suggests that radiotherapy might improve these symptoms in a relatively short period. We report 3 cases of orbital metastasis from breast cancer treated with radiotherapy. All 3 patients were diagnosed with stage Ⅳ breast cancer and underwent chemotherapy and endocrine therapy for several years. https://www.selleckchem.com/products/Vorinostat-saha.html When they were diagnosed with orbital metastasis, their life expectancy was only a few months with debilitating illness. They received radiotherapy, which caused slight side effects including skin disorders. The cancer symptoms rapidly improved in 2 patients, suggesting that radiotherapy can be an efficacious choice for improving the QOL for patients with orbital metastasis from breast cancer, especially for patients in terminal status.A 72-year-old woman was admitted to our hospital because of symptoms of bleeding diathesis such as hematuria and purpura. A blood test revealed disseminated intravascular coagulation(DIC). Upper gastrointestinal endoscopy showed advanced gastric cancer. Bone marrow aspiration cytology demonstrated diffuse hyperplasia of large atypical cells, and metastasis of the epithelial tumor was suspected on immunohistochemical examination. She was diagnosed with disseminated carcinomatosis of the bone marrow associated with gastric cancer accompanied by DIC. She was treated with weekly infusion of methotrexate 100 mg/m2 plus 5-fluorouracil 600 mg/m2 for 4 courses; and she completely recovered from DIC. She received oral tegafur/gimeracil/oteracil as an outpatient. However, DIC recurred 126 days after the initial chemotherapy, and 5-fluorouracil plus cisplatin was administered subsequently. After 1 course, she died 166 days after the initial chemotherapy. Although the prognosis of patients with disseminated carcinomatosis of the bone marrow associated with gastric cancer accompanied by DIC is extremely poor, this case shows that secession of DIC and prognostic improvement by chemotherapy could occur. Chemotherapy could be considered a potentially effective treatment in this case.A 61-year-old woman, who consulted another doctor with chief complaints of epigastric pain, nausea, anorexia, palpitation, and shortness of breath since a month was referred to our hospital for diagnosis and treatment. She was diagnosed with advanced gastric cancer. She was also found to have severe anemia(hemoglobin 1.8 g/dL)and malnutrition. With adequate precautions to prevent development of heart failure and refeeding syndrome, the patient was treated for anemia with blood transfusion and intravenous iron injection; and for malnutrition with intravenous hyperalimentation and enteral nutrition. The patient underwent distal gastrectomy 17 days after admission. Histological examination revealed a type 3 moderately differentiated tubular adenocarcinoma>solid type of poorly differentiated adenocarcinoma>mucinous adenocarcinoma corresponding to pT4a, pN3a, pStage ⅢB, respectively. The postoperative course was good and adjuvant chemotherapy was started 22 days after surgery. However, the patient died approximately 15 months after surgery due to metastases of gastric cancer to the lymph nodes.
To evaluate the efficacy and safety of CAPOX plus bevacizumab as second-line chemotherapy for metastatic colorectal cancer.

In this multicenter phase Ⅱ study, the planned number of patients was 48, but owing to poor case accumulation, registration was discontinued for 20 patients. The primary endpoint was the response rate(RR). Secondary endpoints were progression-free survival(PFS), overall survival(OS), disease control rate(DCR), and safety.

First-line treatment was combined with irinotecan in 14 cases and bevacizumab in 12 cases. The median number of second- line treatment courses was 7, and the median treatment period was 203 days. The reason for discontinuation of treatment was disease progression in 13 cases, adverse events in 4 cases, and other reasons in 3 cases. The best response was PR in 5 cases, SD in 8 cases, and NE in 4 cases. The RR was 25%, and the DCR was 65%. The median PFS was 7.2 months, and the median OS was 18.6 months. Grade≥3 adverse events were neutropenia in 3 cases and diarrhea and peripheral neuropathy in 2 cases each. There were no treatment-related deaths.

CAPOX plus bevacizumab was a safe and effective second-line treatment option for metastatic colorectal cancer.
CAPOX plus bevacizumab was a safe and effective second-line treatment option for metastatic colorectal cancer.To the effect of chemotherapy in cancer patients, in addition to direct cytotoxicity against cancer cells, contribution of tumor immune-mediated mechanisms have been reported. To elucidate the immune environment involved in the response to chemotherapy in esophageal cancer, we collected pre-treatment biopsy tissues from 86 patients, performed multiple staining with fluorescein-labeled tyramide, and analyzed lymphocytes and macrophages using a variable-wavelength filter fluorescence microscope to compare the effects of chemotherapy. Although there was no correlation with various T-cell fractions, high levels of CD163- or CD206-positive M2 macrophages (TAM) were significantly associated with chemotherapy non-responders. The results suggest that the combination of TAM inhibitors may be useful in overcoming chemotherapy resistance in esophageal cancer.
Though irinotecan is commonly used for treating advanced gastric cancer, there is no predictive biomarker to date. We have studied the resistant mechanism for irinotecan and found that phosphorylation of serine 10 residue of topoisomerase Ⅰ(topo Ⅰ)is an important step for irinotecan resistance. We have developed an immunohistochemical staining-based biomarker; topo Ⅰ-pS10, for predicting irinotecan efficacy.

The purpose of this study is to test the accuracy of topo Ⅰ-pS10 immunohistochemical staining in gastric cancer clinical samples.

In this study we performed 2 sets of tests. In the training set, we stained 79 gastric cancer clinical samples which efficacy of irinotecan was measured by succinate dehydrogenase inhibition(SDI)test. In the validation set, we used 27 gastric cancer clinical samples which irinotecan was used and the efficacy was known.

Training set From the ROC curve the cut-off point was set at 35% positive nuclei. Sixty three cases were positive with topo Ⅰ-pS10 in the nuclei. With the result of irinotecan SDI, the sensitivity was 76.