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20 hrs ago


Our study suggests that in an emerging immigrant community familism values are primarily associated with positive adaptation through distinct mechanisms. (PsycInfo Database Record (c) 2020 APA, all rights reserved).The purpose of this study is to examine how parents' documentation status informs their ethnic-racial socialization (ERS) practices and the subsequent implications for Latinx youths' psychological adjustment. The mixed-methods approach combined convergent and exploratory sequential designs to explore the breadth and depth of Latinx parents' messages to their children regarding race and ethnicity. Qualitative data were used to generate hypotheses that were tested quantitatively. Analysis of interviews revealed parents' concerns with obeying the law, avoiding interaction with others, teaching children how to deal with discrimination, the importance of transmitting their culture, and concerns for their children's ever-present fear and stress. Path analysis showed that undocumented parents utilized more cultural socialization and promotion of mistrust messages than their documented counterparts. https://www.selleckchem.com/products/nec-1s-7-cl-o-nec1.html More promotion of mistrust, in turn, was associated with higher levels of adolescent depressive symptoms. Given the current sociopolitical climate and ethnic-racial tensions in the United States, it is imperative to gain a more comprehensive understanding of the nuanced ERS practices Latinx families employ to both cope with and respond to this situation. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Despite its implications for positive youth development, factors and processes that promote civic engagement are critically understudied, particularly among Muslim American adolescents for whom opportunities for civic engagement could be hindered by Islamophobia and hate crimes. Prior work has proposed that parents can strengthen adolescents' group belonging and motivate their civic engagement, but this mediating link has not been empirically tested. Moreover, parents' religious socialization and adolescents' religious identity remain understudied, especially with respect to possible daily fluctuations. We used experience sampling methods to (a) explore momentary fluctuations and temporal relations between two dimensions of Muslim American adolescents' religious identity (i.e., private regard and centrality) over the course of 14 days (Phase 2), and (b) examine if Muslim American adolescents' momentary religious identity (Phase 2) mediated associations between their stable perceptions of maternal religious socialization (Phase 1) and subsequent civic engagement (Phase 3). Dynamic structural equation modeling revealed positive autoregressive and cross-lagged relations between religious private regard and centrality. Moreover, adolescents' momentary religious identities differentially mediated the associations between maternal religious socialization and civic attitudes and behaviors, suggesting specificity in these developmental processes. Our findings have important implications for programs and policies to support the self-empowerment and positive development of Muslim American adolescents. (PsycInfo Database Record (c) 2020 APA, all rights reserved).The parenting practices of both transracially adopted Korean American adults and multiracial families are often overlooked in developmental science, yet are important to address, given that the majority of Korean adoptees are now adults with families of their own and given rapid increases in the multiracial population. This qualitative study examined the cultural socialization beliefs and practices among transracially adopted Korean Americans who are parents of multiracial Asian-White children. Drawing upon interviews with 31 Korean adoptee parents (29 female; Mage = 41.26), we identified four themes that capture parents' understanding of their children's multiracial identities, how that understanding subsequently shapes their cultural socialization practices, and how parents' socialization beliefs and practices vary by developmental stage. These themes described the ways that parents' cultural socialization practices were shaped by their children's phenotypes, parents' understanding of their children's multiracial identities, geographic location, and the multiracial family context. This study also demonstrated how multiracial couples in our sample engaged in cultural socialization together. Results suggest that Korean adoptee parents largely acknowledged their children's multiracial identities through labels, but primarily socialized children as monoracial minorities. (PsycInfo Database Record (c) 2020 APA, all rights reserved).This introduction to the special section on hidden populations across contexts in developmental science defines what is meant by "hidden populations" and summarizes the studies along thematic lines. Hidden populations are generally minoritized populations embedded in larger systems of oppression and inequality encapsulated within historical time and place, and importantly, they are underrepresented in developmental science. The set of 8 empirical articles discusses how being "hidden" is contextualized and operationalized through explicit and implicit ways and uses multiple methodologies to elucidate the experiences of children, youth, and families. The collection of articles is grounded in developmental and sociocultural developmental theories highlighting important cultural and contextual developmental mechanisms that impact and promote the well-being of hidden populations. Thematically, the set of articles, implicitly and explicitly, addresses minoritization and its consequences as well as elucidates resilience through multiple processes at different levels. Together, the special section advances developmental science by diversifying the populations that are represented to understand normative and culturally and contextually dependent development. (PsycInfo Database Record (c) 2020 APA, all rights reserved).In the wake of COVID-19, the capacity to track emerging trends in mental health symptoms and needs will guide public health responses at multiple ecological levels. Using Google Trends to track population-level mental health-related Google searches in the United States, this investigation identified pandemic-associated spikes in searches related to anxiety symptoms and remote treatments for anxiety, such as deep breathing and body scan meditation. As other discernable population-level changes in mental health have yet to emerge, continued surveillance is warranted. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

22 hrs ago


This study investigated a) racial/ethnic differences in past-year discrimination experiences and b) associations between discrimination and smoking abstinence.

Prospective, longitudinal analysis of smoking status. Perceived past-year discrimination was assessed at baseline. ANCOVAs and intent-to-treat hierarchical logistic regressions were conducted.

Dual-site (Tampa, FL and Miami, FL) randomized controlled trial testing the effects of a group cessation intervention plus pharmacotherapy.

Treatment-seeking adult smokers (N=347; non-Hispanic White, non-Hispanic African American/Black, or Hispanic).

Biochemically verified 7-day point prevalence abstinence (7-day ppa) was assessed immediately post-intervention and at 6-month follow-up.

After controlling for covariates, African Americans/Blacks reported greater perceived discrimination compared with non-Hispanic Whites (P=.02), and Hispanics (P=.06). Non-Hispanic Whites and Hispanics did not differ in perceived racial/ethnic discrimination experiences ion was greater among African American/Black smokers compared with non-Hispanic Whites. Perceived discrimination was negatively associated with tobacco cessation in the full sample, and for African Americans at 6-months post-intervention. These data have implications for intervention delivery and health disparities.
There is limited information regarding the prevalence and predictors of cost-related non-utilization (CRNU), while there is increasing attention to the rising out-of-pocket cost of health services including prescription medications. Prior studies have not quantified the role of perceived racism despite its documented relationship with health services utilization. We examine perceptions of reactions to race and quantify their relationship with CRNU.

This retrospective cross-sectional study utilized data from the 2014 Behavioral Risk Factor Surveillance System (BRFSS) public use file, an annual, state-based telephone survey of US adults aged 18 and older. https://www.selleckchem.com/products/ag-270.html We utilized data for four states that provided responses to five Reactions to Race items, including information about the self-perceived quality of the respondent's health care experience compared with people of other races (worse vs same or better) and whether the respondent experienced physical symptoms because of treatment due to their race. The three b associated with CRNU (physician visit 2.6 [95% CI 1.7 - 4]; prescription fills 2.1 [1.2 - 3.6]). No Reactions to Race items were associated with general non-utilization.

Negative perceptions of reactions to race during the time of health services utilization is positively associated with CRNU, ie, foregoing physician visits and prescription fills due to cost.
Negative perceptions of reactions to race during the time of health services utilization is positively associated with CRNU, ie, foregoing physician visits and prescription fills due to cost.
Despite improvements in infant mortality rates (IMR) in the United States, racial gaps in IMR remain and may be driven by both structural racism and place. This studyassesses the relationship betweenstructural racism and race-specific IMR and the role of urban-rural classification on race-specific IMR and Black/White racial gaps in IMR.

We conducted an analysis of variance tests using 2019 County Health Rankings Data to determine differences in structural racism indicators, IMR and other co-variates by urban-rural classification. We used linear regressions to determine the associations between measures of structural racism and county-level health outcomes.

Study results suggest that racial inequities in education, work, and homeownership negatively impact Black IMR, especially in large fringe, medium, and small metro counties, and positively impact White IMR. Structural racism is also associated withBlack-White gaps in IMR.

Factors related to structural racism may not be homogenous or have the same impacts on overall IMR, race-specific IMR, and racial differences in IMR across places. Understanding these differential impacts can help public health professionals and policymakers improve Black infant health and eliminate racial inequities in IMR.
Factors related to structural racism may not be homogenous or have the same impacts on overall IMR, race-specific IMR, and racial differences in IMR across places. Understanding these differential impacts can help public health professionals and policymakers improve Black infant health and eliminate racial inequities in IMR.Structural racism is a multilevel system of ideologies, institutions, and processes that have created and reified racial/ethnic inequities. As a system, it works in concert across institutions to propagate racial injustice. Thus, efforts to address structural racism and its implications for health inequity require transdisciplinary collaboration. In this article, we begin by describing the process through which we have leveraged our discipline-specific training -- spanning education, epidemiology, social work, sociology, and urban planning -- to co-construct a transdisciplinary analysis of the determinants of racial health inequity. Specifically, we introduce the underlying theories that guide our framework development and demonstrate the application of our integrated framework through a case example. We conclude with potential research and policy implications.
One of the fundamental challenges in research on, and the practice of, anti-racism is helping people open their minds to new possibilities and new ways of thinking.

This commentary illustrates how art can help people unlearn misinformation and narrow ways of thinking while enhancing flexibility that allows people to think creatively about efforts to eliminate or mitigate the health effects of racism.

Historically, art has been a critical foundation of the history of protest and struggle to achieve equity in the United States and across the globe. Whether music, poems, paintings or other forms of creative expression, art has been at the core of efforts to express emotion, communicate difficult concepts, spur action and change what seems impossible. Art has been particularly important in illustrating and helping to facilitate how people understand what racism is, how it feels to experience privilege or oppression and exploring the implications of policies and practices that affect health indirectly or directly.

01/22/2025


Based on the current review, it can be confirmed that nanoparticles such as dendrimer, Au, Ag and iron oxide nanoparticles with smaller size and negative charge have significant advantages for improving the efficacy of platelets during the storage chain and inhibition of their aggregation.
Based on the current review, it can be confirmed that nanoparticles such as dendrimer, Au, Ag and iron oxide nanoparticles with smaller size and negative charge have significant advantages for improving the efficacy of platelets during the storage chain and inhibition of their aggregation.Proper cell fate determination is largely orchestrated by complex gene regulatory networks centered around transcription factors. However, experimental elucidation of key transcription factors that drive cellular identity is currently often intractable. Here, we present ANANSE (ANalysis Algorithm for Networks Specified by Enhancers), a network-based method that exploits enhancer-encoded regulatory information to identify the key transcription factors in cell fate determination. As cell type-specific transcription factors predominantly bind to enhancers, we use regulatory networks based on enhancer properties to prioritize transcription factors. First, we predict genome-wide binding profiles of transcription factors in various cell types using enhancer activity and transcription factor binding motifs. Subsequently, applying these inferred binding profiles, we construct cell type-specific gene regulatory networks, and then predict key transcription factors controlling cell fate transitions using differential networks between cell types. This method outperforms existing approaches in correctly predicting major transcription factors previously identified to be sufficient for trans-differentiation. Finally, we apply ANANSE to define an atlas of key transcription factors in 18 normal human tissues. In conclusion, we present a ready-to-implement computational tool for efficient prediction of transcription factors in cell fate determination and to study transcription factor-mediated regulatory mechanisms. ANANSE is freely available at https//github.com/vanheeringen-lab/ANANSE.Behavioral medicine research and practice have not traditionally acknowledged the detrimental effects of anti-Black racism (and other forms of systemic oppression) on health, interventions, or research. This commentary describes four ways that behavioral medicine researchers and clinicians can address the past to envision the future of behavioral medicine to promote equitable health for all 1) name anti-Black racism, 2) ensure interventions address structural inequities, 3) advocate for systemic change, and 4) change expectations for publications.RBFOX2 controls the splicing of a large number of transcripts implicated in cell differentiation and development. Parsing RNA-binding protein datasets, we uncover that RBFOX2 can interact with hnRNPC, hnRNPM and SRSF1 to regulate splicing of a broad range of splicing events using different sequence motifs and binding modes. Using immunoprecipitation, specific RBP knockdown, RNA-seq and splice-sensitive PCR, we show that RBFOX2 can target splice sites using three binding configurations single, multiple or secondary modes. In the single binding mode RBFOX2 is recruited to its target splice sites through a single canonical binding motif, while in the multiple binding mode RBFOX2 binding sites include the adjacent binding of at least one other RNA binding protein partner. Finally, in the secondary binding mode RBFOX2 likely does not bind the RNA directly but is recruited to splice sites lacking its canonical binding motif through the binding of one of its protein partners. These dynamic modes bind distinct sets of transcripts at different positions and distances relative to alternative splice sites explaining the heterogeneity of RBFOX2 targets and splicing outcomes.The discovery of HAATIrDNA, a telomerase-negative survival mode in which canonical telomeres are replaced with ribosomal DNA (rDNA) repeats that acquire chromosome end-protection capability, raised crucial questions as to how rDNA tracts 'jump' to eroding chromosome ends. Here, we show that HAATIrDNA formation is initiated and limited by a single translocation that juxtaposes rDNA from Chromosome (Chr) III onto subtelomeric elements (STE) on Chr I or II; this rare reaction requires RNAi and the Ino80 nucleosome remodeling complex (Ino80C), thus defining an unforeseen relationship between these two machineries. The unique STE-rDNA junction created by this initial translocation is efficiently copied to the remaining STE chromosome ends, independently of RNAi or Ino80C. https://www.selleckchem.com/ Intriguingly, both RNAi and Ino80C machineries contain a component that plays dual roles in HAATI subtype choice. Dcr1 of the RNAi pathway and Iec1 of Ino80C both promote HAATIrDNA formation as part of their respective canonical machineries, but both also inhibit formation of the exceedingly rare HAATISTE (where STE sequences mobilize throughout the genome and assume chromosome end protection capacity) in non-canonical, pathway-independent manners. This work provides a glimpse into a previously unrecognized crosstalk between RNAi and Ino80C in controlling unusual translocation reactions that establish telomere-free linear chromosome ends.The yeast cyclic AMP-dependent protein kinase A (PKA) is a ubiquitous serine-threonine kinase, encompassing three catalytic (Tpk1-3) and one regulatory (Bcy1) subunits. Evidence suggests PKA involvement in DNA damage checkpoint response, but how DNA repair pathways are regulated by PKA subunits remains inconclusive. Here, we report that deleting the tpk1 catalytic subunit reduces non-homologous end joining (NHEJ) efficiency, whereas tpk2-3 and bcy1 deletion does not. Epistatic analyses revealed that tpk1, as well as the DNA damage checkpoint kinase (dun1) and NHEJ factor (nej1), co-function in the same pathway, and parallel to the NHEJ factor yku80. Chromatin immunoprecipitation and resection data suggest that tpk1 deletion influences repair protein recruitments and DNA resection. Further, we show that Tpk1 phosphorylation of Nej1 at S298 (a Dun1 phosphosite) is indispensable for NHEJ repair and nuclear targeting of Nej1 and its binding partner Lif1. In mammalian cells, loss of PRKACB (human homolog of Tpk1) also reduced NHEJ efficiency, and similarly, PRKACB was found to phosphorylate XLF (a Nej1 human homolog) at S263, a corresponding residue of the yeast Nej1 S298.

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Joining me once again today is Zachary Foster PhD, here to discuss the true origin of Hamas and how this is central to many of the lies being promoted currently by the Israeli government and its supporters. We also discuss the history of peaceful resistance of the Palestinian people, even in the face of brutal oppression, as well as the overall decline of the Apartheid state of Israel. 

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Commemorating the 250th Anniversary of Dr. Benjamin Church’s Massacre Day Oration in 1773. A leader with the Sons of Liberty - and the first Surgeon General - he urged the people to respond to the bloodshed of 1770 with “manly rage; against the foul oppression, of quartering troops, in populous cities, in times of peace.” He focused heavily on the principle of delegated and reserved powers. But this story of a one-time hero ends with a massive twist most are never taught today.

Path to Liberty: March 6, 2023

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Joining me once again today is Zachary Foster PhD, here to discuss the true origin of Hamas and how this is central to many of the lies being promoted currently by the Israeli government and its supporters. We also discuss the history of peaceful resistance of the Palestinian people, even in the face of brutal oppression, as well as the overall decline of the Apartheid state of Israel. 

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Commemorating the 250th Anniversary of Dr. Benjamin Church’s Massacre Day Oration in 1773. A leader with the Sons of Liberty - and the first Surgeon General - he urged the people to respond to the bloodshed of 1770 with “manly rage; against the foul oppression, of quartering troops, in populous cities, in times of peace.” He focused heavily on the principle of delegated and reserved powers. But this story of a one-time hero ends with a massive twist most are never taught today.

Path to Liberty: March 6, 2023

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Commemorating the 250th Anniversary of Dr. Joseph Warren’s Massacre Day Oration in 1772. The great patriot and revolutionary war hero urged the people to never forget the bloodshed of Mar. 5, 1770. But he also focused on a natural rights foundation and warned future generations of the great danger of standing armies, “the ready engines of tyranny and oppression” - which they experienced first hand in Boston.

Path to Liberty, Fast Friday Edition: March 4, 2022

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20 hrs ago


Our study suggests that in an emerging immigrant community familism values are primarily associated with positive adaptation through distinct mechanisms. (PsycInfo Database Record (c) 2020 APA, all rights reserved).The purpose of this study is to examine how parents' documentation status informs their ethnic-racial socialization (ERS) practices and the subsequent implications for Latinx youths' psychological adjustment. The mixed-methods approach combined convergent and exploratory sequential designs to explore the breadth and depth of Latinx parents' messages to their children regarding race and ethnicity. Qualitative data were used to generate hypotheses that were tested quantitatively. Analysis of interviews revealed parents' concerns with obeying the law, avoiding interaction with others, teaching children how to deal with discrimination, the importance of transmitting their culture, and concerns for their children's ever-present fear and stress. Path analysis showed that undocumented parents utilized more cultural socialization and promotion of mistrust messages than their documented counterparts. https://www.selleckchem.com/products/nec-1s-7-cl-o-nec1.html More promotion of mistrust, in turn, was associated with higher levels of adolescent depressive symptoms. Given the current sociopolitical climate and ethnic-racial tensions in the United States, it is imperative to gain a more comprehensive understanding of the nuanced ERS practices Latinx families employ to both cope with and respond to this situation. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Despite its implications for positive youth development, factors and processes that promote civic engagement are critically understudied, particularly among Muslim American adolescents for whom opportunities for civic engagement could be hindered by Islamophobia and hate crimes. Prior work has proposed that parents can strengthen adolescents' group belonging and motivate their civic engagement, but this mediating link has not been empirically tested. Moreover, parents' religious socialization and adolescents' religious identity remain understudied, especially with respect to possible daily fluctuations. We used experience sampling methods to (a) explore momentary fluctuations and temporal relations between two dimensions of Muslim American adolescents' religious identity (i.e., private regard and centrality) over the course of 14 days (Phase 2), and (b) examine if Muslim American adolescents' momentary religious identity (Phase 2) mediated associations between their stable perceptions of maternal religious socialization (Phase 1) and subsequent civic engagement (Phase 3). Dynamic structural equation modeling revealed positive autoregressive and cross-lagged relations between religious private regard and centrality. Moreover, adolescents' momentary religious identities differentially mediated the associations between maternal religious socialization and civic attitudes and behaviors, suggesting specificity in these developmental processes. Our findings have important implications for programs and policies to support the self-empowerment and positive development of Muslim American adolescents. (PsycInfo Database Record (c) 2020 APA, all rights reserved).The parenting practices of both transracially adopted Korean American adults and multiracial families are often overlooked in developmental science, yet are important to address, given that the majority of Korean adoptees are now adults with families of their own and given rapid increases in the multiracial population. This qualitative study examined the cultural socialization beliefs and practices among transracially adopted Korean Americans who are parents of multiracial Asian-White children. Drawing upon interviews with 31 Korean adoptee parents (29 female; Mage = 41.26), we identified four themes that capture parents' understanding of their children's multiracial identities, how that understanding subsequently shapes their cultural socialization practices, and how parents' socialization beliefs and practices vary by developmental stage. These themes described the ways that parents' cultural socialization practices were shaped by their children's phenotypes, parents' understanding of their children's multiracial identities, geographic location, and the multiracial family context. This study also demonstrated how multiracial couples in our sample engaged in cultural socialization together. Results suggest that Korean adoptee parents largely acknowledged their children's multiracial identities through labels, but primarily socialized children as monoracial minorities. (PsycInfo Database Record (c) 2020 APA, all rights reserved).This introduction to the special section on hidden populations across contexts in developmental science defines what is meant by "hidden populations" and summarizes the studies along thematic lines. Hidden populations are generally minoritized populations embedded in larger systems of oppression and inequality encapsulated within historical time and place, and importantly, they are underrepresented in developmental science. The set of 8 empirical articles discusses how being "hidden" is contextualized and operationalized through explicit and implicit ways and uses multiple methodologies to elucidate the experiences of children, youth, and families. The collection of articles is grounded in developmental and sociocultural developmental theories highlighting important cultural and contextual developmental mechanisms that impact and promote the well-being of hidden populations. Thematically, the set of articles, implicitly and explicitly, addresses minoritization and its consequences as well as elucidates resilience through multiple processes at different levels. Together, the special section advances developmental science by diversifying the populations that are represented to understand normative and culturally and contextually dependent development. (PsycInfo Database Record (c) 2020 APA, all rights reserved).In the wake of COVID-19, the capacity to track emerging trends in mental health symptoms and needs will guide public health responses at multiple ecological levels. Using Google Trends to track population-level mental health-related Google searches in the United States, this investigation identified pandemic-associated spikes in searches related to anxiety symptoms and remote treatments for anxiety, such as deep breathing and body scan meditation. As other discernable population-level changes in mental health have yet to emerge, continued surveillance is warranted. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

22 hrs ago


This study investigated a) racial/ethnic differences in past-year discrimination experiences and b) associations between discrimination and smoking abstinence.

Prospective, longitudinal analysis of smoking status. Perceived past-year discrimination was assessed at baseline. ANCOVAs and intent-to-treat hierarchical logistic regressions were conducted.

Dual-site (Tampa, FL and Miami, FL) randomized controlled trial testing the effects of a group cessation intervention plus pharmacotherapy.

Treatment-seeking adult smokers (N=347; non-Hispanic White, non-Hispanic African American/Black, or Hispanic).

Biochemically verified 7-day point prevalence abstinence (7-day ppa) was assessed immediately post-intervention and at 6-month follow-up.

After controlling for covariates, African Americans/Blacks reported greater perceived discrimination compared with non-Hispanic Whites (P=.02), and Hispanics (P=.06). Non-Hispanic Whites and Hispanics did not differ in perceived racial/ethnic discrimination experiences ion was greater among African American/Black smokers compared with non-Hispanic Whites. Perceived discrimination was negatively associated with tobacco cessation in the full sample, and for African Americans at 6-months post-intervention. These data have implications for intervention delivery and health disparities.
There is limited information regarding the prevalence and predictors of cost-related non-utilization (CRNU), while there is increasing attention to the rising out-of-pocket cost of health services including prescription medications. Prior studies have not quantified the role of perceived racism despite its documented relationship with health services utilization. We examine perceptions of reactions to race and quantify their relationship with CRNU.

This retrospective cross-sectional study utilized data from the 2014 Behavioral Risk Factor Surveillance System (BRFSS) public use file, an annual, state-based telephone survey of US adults aged 18 and older. https://www.selleckchem.com/products/ag-270.html We utilized data for four states that provided responses to five Reactions to Race items, including information about the self-perceived quality of the respondent's health care experience compared with people of other races (worse vs same or better) and whether the respondent experienced physical symptoms because of treatment due to their race. The three b associated with CRNU (physician visit 2.6 [95% CI 1.7 - 4]; prescription fills 2.1 [1.2 - 3.6]). No Reactions to Race items were associated with general non-utilization.

Negative perceptions of reactions to race during the time of health services utilization is positively associated with CRNU, ie, foregoing physician visits and prescription fills due to cost.
Negative perceptions of reactions to race during the time of health services utilization is positively associated with CRNU, ie, foregoing physician visits and prescription fills due to cost.
Despite improvements in infant mortality rates (IMR) in the United States, racial gaps in IMR remain and may be driven by both structural racism and place. This studyassesses the relationship betweenstructural racism and race-specific IMR and the role of urban-rural classification on race-specific IMR and Black/White racial gaps in IMR.

We conducted an analysis of variance tests using 2019 County Health Rankings Data to determine differences in structural racism indicators, IMR and other co-variates by urban-rural classification. We used linear regressions to determine the associations between measures of structural racism and county-level health outcomes.

Study results suggest that racial inequities in education, work, and homeownership negatively impact Black IMR, especially in large fringe, medium, and small metro counties, and positively impact White IMR. Structural racism is also associated withBlack-White gaps in IMR.

Factors related to structural racism may not be homogenous or have the same impacts on overall IMR, race-specific IMR, and racial differences in IMR across places. Understanding these differential impacts can help public health professionals and policymakers improve Black infant health and eliminate racial inequities in IMR.
Factors related to structural racism may not be homogenous or have the same impacts on overall IMR, race-specific IMR, and racial differences in IMR across places. Understanding these differential impacts can help public health professionals and policymakers improve Black infant health and eliminate racial inequities in IMR.Structural racism is a multilevel system of ideologies, institutions, and processes that have created and reified racial/ethnic inequities. As a system, it works in concert across institutions to propagate racial injustice. Thus, efforts to address structural racism and its implications for health inequity require transdisciplinary collaboration. In this article, we begin by describing the process through which we have leveraged our discipline-specific training -- spanning education, epidemiology, social work, sociology, and urban planning -- to co-construct a transdisciplinary analysis of the determinants of racial health inequity. Specifically, we introduce the underlying theories that guide our framework development and demonstrate the application of our integrated framework through a case example. We conclude with potential research and policy implications.
One of the fundamental challenges in research on, and the practice of, anti-racism is helping people open their minds to new possibilities and new ways of thinking.

This commentary illustrates how art can help people unlearn misinformation and narrow ways of thinking while enhancing flexibility that allows people to think creatively about efforts to eliminate or mitigate the health effects of racism.

Historically, art has been a critical foundation of the history of protest and struggle to achieve equity in the United States and across the globe. Whether music, poems, paintings or other forms of creative expression, art has been at the core of efforts to express emotion, communicate difficult concepts, spur action and change what seems impossible. Art has been particularly important in illustrating and helping to facilitate how people understand what racism is, how it feels to experience privilege or oppression and exploring the implications of policies and practices that affect health indirectly or directly.

01/22/2025


Based on the current review, it can be confirmed that nanoparticles such as dendrimer, Au, Ag and iron oxide nanoparticles with smaller size and negative charge have significant advantages for improving the efficacy of platelets during the storage chain and inhibition of their aggregation.
Based on the current review, it can be confirmed that nanoparticles such as dendrimer, Au, Ag and iron oxide nanoparticles with smaller size and negative charge have significant advantages for improving the efficacy of platelets during the storage chain and inhibition of their aggregation.Proper cell fate determination is largely orchestrated by complex gene regulatory networks centered around transcription factors. However, experimental elucidation of key transcription factors that drive cellular identity is currently often intractable. Here, we present ANANSE (ANalysis Algorithm for Networks Specified by Enhancers), a network-based method that exploits enhancer-encoded regulatory information to identify the key transcription factors in cell fate determination. As cell type-specific transcription factors predominantly bind to enhancers, we use regulatory networks based on enhancer properties to prioritize transcription factors. First, we predict genome-wide binding profiles of transcription factors in various cell types using enhancer activity and transcription factor binding motifs. Subsequently, applying these inferred binding profiles, we construct cell type-specific gene regulatory networks, and then predict key transcription factors controlling cell fate transitions using differential networks between cell types. This method outperforms existing approaches in correctly predicting major transcription factors previously identified to be sufficient for trans-differentiation. Finally, we apply ANANSE to define an atlas of key transcription factors in 18 normal human tissues. In conclusion, we present a ready-to-implement computational tool for efficient prediction of transcription factors in cell fate determination and to study transcription factor-mediated regulatory mechanisms. ANANSE is freely available at https//github.com/vanheeringen-lab/ANANSE.Behavioral medicine research and practice have not traditionally acknowledged the detrimental effects of anti-Black racism (and other forms of systemic oppression) on health, interventions, or research. This commentary describes four ways that behavioral medicine researchers and clinicians can address the past to envision the future of behavioral medicine to promote equitable health for all 1) name anti-Black racism, 2) ensure interventions address structural inequities, 3) advocate for systemic change, and 4) change expectations for publications.RBFOX2 controls the splicing of a large number of transcripts implicated in cell differentiation and development. Parsing RNA-binding protein datasets, we uncover that RBFOX2 can interact with hnRNPC, hnRNPM and SRSF1 to regulate splicing of a broad range of splicing events using different sequence motifs and binding modes. Using immunoprecipitation, specific RBP knockdown, RNA-seq and splice-sensitive PCR, we show that RBFOX2 can target splice sites using three binding configurations single, multiple or secondary modes. In the single binding mode RBFOX2 is recruited to its target splice sites through a single canonical binding motif, while in the multiple binding mode RBFOX2 binding sites include the adjacent binding of at least one other RNA binding protein partner. Finally, in the secondary binding mode RBFOX2 likely does not bind the RNA directly but is recruited to splice sites lacking its canonical binding motif through the binding of one of its protein partners. These dynamic modes bind distinct sets of transcripts at different positions and distances relative to alternative splice sites explaining the heterogeneity of RBFOX2 targets and splicing outcomes.The discovery of HAATIrDNA, a telomerase-negative survival mode in which canonical telomeres are replaced with ribosomal DNA (rDNA) repeats that acquire chromosome end-protection capability, raised crucial questions as to how rDNA tracts 'jump' to eroding chromosome ends. Here, we show that HAATIrDNA formation is initiated and limited by a single translocation that juxtaposes rDNA from Chromosome (Chr) III onto subtelomeric elements (STE) on Chr I or II; this rare reaction requires RNAi and the Ino80 nucleosome remodeling complex (Ino80C), thus defining an unforeseen relationship between these two machineries. The unique STE-rDNA junction created by this initial translocation is efficiently copied to the remaining STE chromosome ends, independently of RNAi or Ino80C. https://www.selleckchem.com/ Intriguingly, both RNAi and Ino80C machineries contain a component that plays dual roles in HAATI subtype choice. Dcr1 of the RNAi pathway and Iec1 of Ino80C both promote HAATIrDNA formation as part of their respective canonical machineries, but both also inhibit formation of the exceedingly rare HAATISTE (where STE sequences mobilize throughout the genome and assume chromosome end protection capacity) in non-canonical, pathway-independent manners. This work provides a glimpse into a previously unrecognized crosstalk between RNAi and Ino80C in controlling unusual translocation reactions that establish telomere-free linear chromosome ends.The yeast cyclic AMP-dependent protein kinase A (PKA) is a ubiquitous serine-threonine kinase, encompassing three catalytic (Tpk1-3) and one regulatory (Bcy1) subunits. Evidence suggests PKA involvement in DNA damage checkpoint response, but how DNA repair pathways are regulated by PKA subunits remains inconclusive. Here, we report that deleting the tpk1 catalytic subunit reduces non-homologous end joining (NHEJ) efficiency, whereas tpk2-3 and bcy1 deletion does not. Epistatic analyses revealed that tpk1, as well as the DNA damage checkpoint kinase (dun1) and NHEJ factor (nej1), co-function in the same pathway, and parallel to the NHEJ factor yku80. Chromatin immunoprecipitation and resection data suggest that tpk1 deletion influences repair protein recruitments and DNA resection. Further, we show that Tpk1 phosphorylation of Nej1 at S298 (a Dun1 phosphosite) is indispensable for NHEJ repair and nuclear targeting of Nej1 and its binding partner Lif1. In mammalian cells, loss of PRKACB (human homolog of Tpk1) also reduced NHEJ efficiency, and similarly, PRKACB was found to phosphorylate XLF (a Nej1 human homolog) at S263, a corresponding residue of the yeast Nej1 S298.

01/21/2025


098 ± 0.021 μM) with similar biological activity to artemether. The molecule 13 is a typical drug repurposing case due to previous other approved therapeutic uses on Chinese medicine as a non-specific cholinergic antagonist, thus it could be accelerated the drug development process. Additionally, molecular dynamics studies were used to confirm stability of the molecular interactions identified by molecular docking. Thus, representative structures of P. falciparum ENR can be used in a study to propose new derivatives for evaluation of biological activity in vitro and in vivo. Communicated by Ramaswamy H. Sarma.This study explored the factors associated with the engagement of women in intimate partner homicide (IPH) through 10 in-depth interviews with women incarcerated in three correction facilities in Oromiya Regional State of Ethiopia. In addition, key informant interviews and six focus groups involving traditional leaders, Kebele administrators, and community members help triangulate the findings. The study revealed insight into women's social, psychological, and economic status prior to their crime. https://www.selleckchem.com/products/dcemm1.html Low levels of education and economic opportunity, forced marriage, marital dispute due to polygamy, spousal violence, and low levels of community support were associated with IPH. Implications for research, policy, and practice are discussed.Cervical cancer is the fourth most common cancer among women globally, with approximately 580,000 new diagnoses in 2018. Approximately, 90% of deaths from this disease occur in low- and middle-income countries, especially in areas of high HIV prevalence, and largely due to limited prevention and screening opportunities and scarce treatment options. In this overview, we describe the opportunities and challenges faced in many low- and middle-income countries in delivery of cervical cancer detection, treatment and complete pathways of care. In particular, drawing on our experience and that of colleagues, we describe cervical screening and pathways of care provision in Malawi, as a case study of a low-resource country with high incidence and mortality rates of cervical cancer. Screening methods such as cytology - although widely used in high-income countries - have limited relevance in many low-resource settings. The World Health Organization recommends screening using human papillomavirus testing wherever possibdels. For larger lesions and cancers, complete clinical pathways (including loop excision, surgery, radiotherapy, chemotherapy and palliative care) are required for optimal care of women. However, provision of each of these components of cancer control is often limited due to limited infrastructure and lack of trained personnel. Hence, global initiatives to reduce cervical mortality need to adopt a holistic approach to health systems strengthening.Articular cartilage contains a subpopulation of tissue-specific progenitors that are an ideal cell type for cell therapies and generating neo-cartilage for tissue engineering applications. However, it is unclear whether the standard chondrogenic medium employing transforming growth factor-β (TGFβ) isoforms is optimal to differentiate these cells. We therefore used pellet culture to screen progenitors from immature bovine articular cartilage with a number of chondrogenic factors and discovered that bone morphogenetic factor-9 (BMP9) precociously induces their differentiation. This difference was apparent with toluidine blue staining and confirmed by biochemical and transcriptional analyses with BMP9 treated progenitors exhibiting 11-fold and 5-fold greater aggrecan and collagen type II gene expression than TGFβ1 treated progenitors. Quantitative gene expression analysis over 14 days highlighted the rapid and phased nature of BMP9 induced chondrogenesis with sequential activation of aggrecan then collagen type artilage, a highly desirable attribute for in vitro tissue-engineered cartilage.BACKGROUND Stomatitis is highly prevalent in patients with cancer treated with the mammalian target of rapamycin inhibitor everolimus; it usually has an early onset and may compromise treatment dose intensity and patients' quality of life. Within the randomized controlled Stomatitis Prevention trial (STOP, ISRCTN14568888), we investigated the possibility of using a commercial natural multicomponent mouthwash (Orasol Plus®) to prevent the development of stomatitis of any grade in patients with advanced renal cell carcinoma (RCC) treated with everolimus. METHODS Overall, 62 patients were randomized to receive either Orasol Plus in addition to oral hygiene or oral hygiene alone (31 patients per treatment arm). RESULTS In the whole study population, 28 episodes of stomatitis were observed (41.9%); in only 2 patients, stomatitis occurred more than once (2 episodes). As expected, the episodes of stomatitis occurred early in the course of treatment with everolimus. Treatment with Orasol Plus prevented the onset of everolimus-induced stomatitis only 8 episodes of stomatitis were observed in the treated group with Orasol Plus in addition to oral hygiene vs 20 episodes in the group treated with oral hygiene only (p = 0021). Also, a reduction in the average duration of mucositis in patients treated with Orasol Plus compared to patients treated with oral hygiene only was observed (8 days vs 11.2 days, p = 0.0416). CONCLUSION This study showed that the use of a natural multicomponent mouthwash coupled with regular oral hygiene was able to reduce the severity and duration of everolimus-induced stomatitis in patients with RCC. TRIAL REGISTRATION NUMBER ISRCTN14568888.Responding to the need for more information concerning the mental health and psychological well-being of women living amid political oppression and war, this study aimed to explore specific factors that contribute to women's individual and collective perceptions about war and the associated traumatic life events that occurred during their lives. Moving from a socioecological and culture-informed perspective, we used narrative timelines elicited from 21 Palestinian women in Gaza, both individually and collectively, as a tool for both data collection and intervention. A deductive, top-down, thematic content analysis procedure was used to categorize data. The main events outlined by the women in their historical accounts, both individual and collective, were linked to political events in and surrounding Palestine. The life events' calendars reflect a constant attempt in balancing and compensating traumatic events with sources of well-being related to social support and family. Individual and collective narrative activities contributed to generate a significant reframing in the attribution of meaning and emotional perceptions of the participants.

01/21/2025


Into the 5-week test, 180 54-week-old Qiling breeder hens had been arbitrarily divided in to three remedies with five replicates and supplemented with three quantities of ALA (0, 300 and 600 mg/kg) into the fundamental corn-soya bean meal diet plans. 600 mg/kg ALA therapy group (HLA) dramatically enhanced the eggshell depth and strength (p .05). The amount of HDL-C, ALB and estradiol (E2) associated with serum when you look at the HLA group had been elevated compared with the CON group (p less then .05). In inclusion, ALA (600 mg/kg) treatment exhibited a low level of serum AST and TG (p less then .05). Dietary ALA enhanced the experience of hepatic lipase in liver (p less then .05). Supplemental 600 mg/kg ALA also improved the SOD activity and complete anti-oxidant ability level, along with a decreased MDA in ovarian structure (p less then .05). Furthermore, the mRNA expressions of ESR1, ESR2, VTG2 and ApoB within the liver and FSHR in follicles were upregulated into the HLA group (p less then .05). In summary, dietary supplementation with 600 mg/kg ALA during the late egg-laying period could improve lipid metabolic rate and reproductive performance of breeder hens.There keeps growing evidence demonstrating that nursing pupils encounter unsafe and poor clinical training when on medical placement. The effect on nursing pupils continues to be reasonably under-explored, particularly in the Australian context. This two-phased qualitative study used Interpretive Description to explore 53 pre-registration nursing students' perceptions and experiences of talking up for diligent security. Results of the study identified students believe speaking up is the best move to make, and their particular professional responsibility. The study results increase earlier analysis by explaining the dissonance students experience due to the inconsistencies between what is taught at university and performed in rehearse. Pupil's stress arises whenever observing nurses using quick cuts, justifying such actions and making excuses about bad practice. Pupils report experiencing dissonance, bewilderment and confusion as well as times, fury whenever observing bad rehearse. The medical environment tradition influences students' choices to speak up or stay hushed. Understanding pupils' perceptions and reactions will market awareness and discussion essential to the near future growth of curricula and medical assistance strategies which will enable pupils to speak up. To evaluate rural paediatric diabetic telehealth centers including if they meet medical standards, offer equivalent treatment to central clinics, families were happy https://bms-754807inhibitor.com/microrna-based-multitarget-way-of-alzheimers-breakthrough-in-the-first-in-class-double-inhibitor-involving-acetylcholinesterase-as-well-as-microrna-15b-biogenesis/ and problems were experienced. a review of a telehealth service for kids and teenagers with type 1 diabetes mellitus at four rural websites ended up being performed. The situation notes for each patient for 2019 had been reviewed to find out if criteria of paediatric diabetic care had been satisfied. Interviews had been performed at a clinic at each website aided by the kid, parent(s) and staff going to the clinics. A retrospective breakdown of problems in service provision had been undertaken with staff. Nineteen kiddies and adolescents were observed in the telehealth clinics within the year. Eighteen (95%) had been seen four times with point-of-care measurement of glycosylated haemoglobin (HbA1c) and growth by the expert paediatrician and diabetic nurse educator. Complication evaluating was attained timely for 15 (78%) customers, with the continuing to be clients having had the examinations bought. Eleven (56%) patients were assessed by a dietician, six (33%) by social employee and five (27%) by psychologist. All clients and parents reported obtaining great support due to their diabetic issues without having any preferring to wait the main center. There have been no considerable technical troubles. Providing paediatric diabetic care through a telehealth service at outlying hospitals fulfills standards of treatment and was provided without technical troubles. It really is chosen by patients and their parents to attending a central hospital. A model of service is provided that could be replicated somewhere else in Australia.Offering paediatric diabetic treatment through a telehealth service at rural hospitals meets criteria of attention and ended up being supplied without technical difficulties. It's favored by customers and their particular moms and dads to attending a central center. a type of service is presented that could be replicated elsewhere in Australia.Literature on racism, anti-racism, whiteness, nursing training and nurse teachers had been evaluated and analysed when it comes to growth of competition awareness and application of anti-racist pedagogy. The literature describes an oppressive academic environment for non-white identifying individuals, a curriculum that doesn't attend to the personal building of distinction, and a nursing tradition that is not consciously situated in a broader sociopolitical context. A particular concentrate on researches of nurse teachers shows a stark need for personal and professional development towards efficiently delivering anti-racist pedagogy and a deconstruction of white normativity and prominence amongst white faculty. The protection and reproduction of white privilege is identified through the scholarship itself through too little racial analysis, an externalization regarding the reason behind oppression and non-specific study measures and effects. The perseverance and pervasiveness of white prominence in nursing and the not enough anti-racist competence in white educators, especially, merits a shift in anti-racist efforts away from short-term skill acquisition projects to the deconstruction of socialized white supremacy and enactments of white privilege in nursing assistant educators on their own.