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4 hrs ago


Although coronavirus disease 2019 (COVID-19) is a mild infection in most children, a small proportion develop severe or critical illness. Data describing agents with potential antiviral activity continue to expand such that updated guidance is needed regarding use of these agents in children.

A panel of pediatric infectious diseases physicians and pharmacists from 20 geographically diverse North American institutions was convened. Through a series of teleconferences and web-based surveys, a set of guidance statements was developed and refined based on review of the best available evidence and expert opinion.

Given the typically mild course of COVID-19 in children, supportive care alone is suggested for most cases. For children with severe illness, defined as a supplemental oxygen requirement without need for noninvasive or invasive mechanical ventilation or extracorporeal membrane oxygenation (ECMO), remdesivir is suggested, preferably as part of a clinical trial if available. Remdesivir should also be considered for critically ill children requiring invasive or noninvasive mechanical ventilation or ECMO. A duration of 5 days is appropriate for most patients. The panel recommends against the use of hydroxychloroquine or lopinavir-ritonavir (or other protease inhibitors) for COVID-19 in children.

Antiviral therapy for COVID-19 is not necessary for the great majority of pediatric patients. For children with severe or critical disease, this guidance offers an approach for decision-making regarding use of remdesivir.
Antiviral therapy for COVID-19 is not necessary for the great majority of pediatric patients. For children with severe or critical disease, this guidance offers an approach for decision-making regarding use of remdesivir.The cabbage aphid, Brevicoryne brassicae (L.), is one of the major insect pests of cole crops in Iran. In most instances outbreaks are normally kept under control by application of insecticides. In this study, the sublethal effects (LC30) of three insecticides, acetamiprid, buprofezin, and thiamethoxam-lambda cyhalothrin, (TLC) were evaluated on the population growth rate of the progeny of insecticide-treated cabbage aphid adults. The age-stage, two-sex life table method was used to analyze the collected data. The results indicated that the insecticide applications affected the duration of the preadult period, their survival, reproduction, life span/longevity, and consequently, the population growth rate of the F1 generation. The indicators of the greatest sublethal effects were noted in the progeny of the TLC-treated adults. These included the lowest net reproductive rate (R0), intrinsic rate of increase (r), finite rate of increase (λ), and the longest mean generation time (T). https://www.selleckchem.com/products/az32.html The highest values of r, λ, R, and the lowest value of T occurred in the control group followed by, in order, the acetamiprid and buprofezin groups. These research findings will be useful in the development and implementation of future aphid management programs.
The purpose of this explanatory case study is to explain the implementation of interprofessional, multitiered lean daily management (LDM) and to quantitatively report its impact on hospital safety.

This case study explained the framework for LDM implementation and changes in quality metrics associated with the interprofessional, multitiered LDM, implemented at Saint Francis Hospital and Medical Center (SFHMC) at the end of 2018. Concepts from lean, Total Quality Management (TQM) and high reliability science were applied to develop the four tiers and
rounding components of LDM. A two-tailed
-test analysis was utilized to determine statistical significance for serious safety events (SSEs) comparing the intervention period (January 2019-December 2019) to the baseline period (calendar years 2017 and 2018). Other quality and efficiency metrics were also tracked.

LDM was associated with decreased SSEs in 2019 compared to 2017 and 2018 (
≤0.01). There were no reportable central line-associated blood stre any significant capital or other investment.

As hospital systems move from a volume-based to value-based health-care delivery model, dynamic interventions using LDM can play a pivotal role in helping all patients, particularly in underserved settings where lower cost care is required for sustainability, given limited available resources.

While many hospital systems promote organizational rounding as a routine quality improvement process, this study shows that a dynamic, intense LDM model can dramatically improve safety within months. This was done in a challenging urban environment for a high-acuity population with limited resources.
While many hospital systems promote organizational rounding as a routine quality improvement process, this study shows that a dynamic, intense LDM model can dramatically improve safety within months. This was done in a challenging urban environment for a high-acuity population with limited resources.
Proline availability for proline dehydrogenase/proline oxidase (PRODH/POX) may represent switching mechanism between PRODH/POX-dependent apoptosis and autophagy. The aim of the study was to evaluate the impact of overexpression of prolidase (proline releasing enzyme) on apoptosis/autophagy in breast cancer MCF-7 cells.

The model of MCF-7 cells with prolidase overexpression (MCF-7
) was obtained. In order to targeting proline for PRODH/POX-dependent pathways substrate for prolidase, glycyl-proline (GP) was provided and proline utilization for collagen biosynthesis was blocked using 2-methoxyestradiol (MOE). Cell viability was determined using Nucleo-Counter NC-3000. The activity of prolidase was determined by colorimetric assay. DNA, collagen and total protein biosynthesis were determined by radiometric method. Expression of proteins was assessed by Western blot and immunofluorescence bioimaging. Concentration of proline was analyzed by liquid chromatography with mass spectrometry.

Prolidase overexpressF-7 cells contributes to increase in intracellular proline concentration and PRODH/POX-dependent autophagic cell death.
GNB1 encodes a subunit of a heterotrimeric G-protein complex that transduces intracellular signaling cascades. Disruptions to the gene have previously been shown to be embryonic lethal in knockout mice and to cause complex neurodevelopmental disorders in humans. To date, the majority of variants associated with disease in humans have been missense variants in exons 5-7.

Genetic sequencing was performed on two patients presenting with complex neurological phenotypes including intellectual disability, hypotonia, and in one patient seizures. Reported variants were assessed using RNA sequencing and functional BRET/BiFC assays.

A splice variant reported in patient 1 was confirmed to cause usage of a cryptic splice site leading to a truncated protein product. Patient 2 was reported to have a truncating variant. BRET and BiFC assays of both patient variants confirmed both were deficient in inducing GPCR-induced G protein activation due to lack of dimer formation with the Gγ subunit.

Here, we report two patients with functionally confirmed loss of function variants in GNB1 and neurodevelopmental phenotypes including intellectual disability, hypotonia, and seizures in one patient.

4 hrs ago


Snapdragon (Antirrhinum majus L.) flowers are one of the most frequently used edible flowers in different preparations of foods and drinks. https://www.selleckchem.com/products/pitstop-2.html In this study, we examined inhibitory effects of snapdragon flower extract (SFE) against distinctive properties of cancer cells, stimulated growth, and activated metastasis, using H1299 lung cancer and HCT116 colon cancer cell lines. SFE treatment at 100-1,000 μg/ml for 24-72 hr resulted in a time- and dose-dependent growth inhibition in H1299 and HCT116 cells. Cell cycle analysis and Annexin V staining assay further revealed that SFE caused cell cycle arrest at G2/M phase and induction of apoptosis, indicating the growth inhibition by SFE is attributed to its G2/M cell cycle-arresting and apoptosis-inducing activities. SFE dose-dependently enhanced generation of intracellular reactive oxygen species (ROS) and reduced mitochondrial membrane potential in H1299 cells but had no effect on intracellular ROS levels in HCT116 cells, suggesting that the type of apoptosis induced by SFE in H1299 cells is different to that in HCT116 cells. Furthermore, SFE alleviated invasion, levels of matrix metalloproteinases, migration, and adhesion in H1299 and HCT116 cells. These results indicate that SFE not only inhibits cell growth by cell cycle arrest at G2/M and apoptosis induction but also alleviates metastatic properties such as invasion, migration, and adhesion in lung and colon cancer cells.This paper reports the effects of four popular cooking methods viz. grilling, boiling, frying, and microwaving on the proximate and nutritional compositions of freshwater mud eel (FWME) muscle. The moisture content of raw FWME muscle was 74.45%, which was similar in boiled products but lower in grilled, fried, and microwaved products (p ≤ .05). The protein content in raw and cooked FWME muscles varied between 14.49% and 21.28%. There were found 20 different fatty acids in FWME muscle of which palmitic acid was the most abundant one with an amount of 26.51%-29.70% in raw and cooked FWME muscles. FWME muscle contained a substantial amount of ω-3 polyunsaturated fatty acids, ranging from 7.54% to 13.7%. However, the thermal effects during cooking decreased the ω-3 polyunsaturated fatty acid contents. There were seven essential and eight nonessential amino acids available in FWME muscle; among the essential amino acids, lysine content was the highest. Raw and cooked FWME were very rich in calcium, between 794.52 mg/100 g and 883.24 mg/100 g muscle. Among the studied heavy metals, Pb content was the highest. However, all the heavy metal contents were within acceptable limits determined by health risk assessment, that is, target hazard quotient and target cancer risk.This study aimed to develop biscuits with improved nutritional contents using edible fish meal from catfish as the source of macro- and micronutrient enrichment while trying to reduce the input of wheat flour in biscuit-making process. The biscuit was produced using edible fish meal (EFM 0%-40%) from catfish, improved quality breadfruit (IQBF 0%-60%), and wheat flours (WF 0%-40%). Macro (crude protein, fat, fiber, ash, and carbohydrate)- and micro (calcium, magnesium, potassium, phosphorus, sodium, and iron)-nutrient contents of the biscuit were determined. The color (lightness-L*, redness-a*, and yellowness-b*), texture (hardness, springiness, and adhesiveness), and sensory (taste, texture, and overall acceptability) attributes of the biscuits were assessed using standard methods. Model characteristics of the responses were profiled, and numerical optimization technique was used to predict combination/blends that produce biscuits with desired nutritional contents. Moisture, crude protein, fat, fiber, and ash values were in the range of 3.50%-5.57%, 3.06%-15.52%, 13.62%-26.00%, 0.31%-1.40%, and 1.98%-5.32%, respectively. The iron, calcium, and phosphorus contents of the biscuit ranged from 103.85 to 201.30 mg/100 g, 100 to 754 mg/100 g, and 8 mg/100 g to 304 mg/100 g, respectively. Interaction between the models for WF and EFM was significant and this significantly affected the L* (36.37-51.90) and adhesiveness (0.01-0.29) values for color and texture, respectively. Similar observations were also noticed for most of the nutrients. The quadratic models selected for the nutrients were all significant (p less then .05) and the adjusted R2 ranged from 0.61 to 0.84 and 0.59 to 0.97 for the macro- and micronutrients, respectively. In conclusion, a biscuit from IQBF, WF, and EFM of 61.33, 0.07, and 38.60 with protein, fat, ash, iron, and calcium contents of 10.41%, 17.59%, 2.05%, 120.52 mg/100 g, and 500.00 mg/100 g, respectively, was produced.
Central obesity, insulin resistance, dyslipidemia, and hypertension are the core components of metabolic syndrome (MetS) which is coincident with unhealthy dietary habits in the Middle-Eastern countries. The aim of this study was to explore the association between dietary habits and MetS of the adult population living in Yazd Greater Area, Iran.

This is a cross-sectional study that uses the data of a population-based cohort study on Iranian adults, known as Yazd Health Study (YaHS). The relationship between dietary habits and metabolic syndrome among adults (
=2,896) was analyzed using multiple logistic regression method.

The prevalence of MetS among the participants was 32.2%. Outcomes from logistic regression examination show that breakfast consumption has a significant inverse effect on the occurrence of MetS after adjustment for age, education level, physical activity statue, history of chronic diseases, and smoking (odds ratio (OR)=0.38, 95% confidence interval (CI)=0.14, 0.97). This effect remains significant even after adjustment for body mass index (BMI) and reveals that odds of having MetS is 69% lower in breakfast consumers in contrast to nonconsumers (OR=0.31, 95% CI=0.11, 0.87). However, no significant relationship was observed between other dietary habits including consumption of sweetened drinks, sugar cubes, and fast foods and MetS after adjustment for all potential confounders.

This study revealed that eating breakfast has an inverse relationship with metabolic syndrome. To find out stronger evidence in relation to dietary habits and MetS, more researches especially population-based cohort studies are needed to be conducted.
This study revealed that eating breakfast has an inverse relationship with metabolic syndrome. To find out stronger evidence in relation to dietary habits and MetS, more researches especially population-based cohort studies are needed to be conducted.

4 hrs ago


7% were the associated comorbidities. The most common stage by imaging at diagnosis was stage IV (38%), followed by 24% stage V, 19% stage III and 9.5% stage II and 9.5% stage VI. Medical management include bisphosphonates (100%), statins (90.4%) and anticoagulant therapy (28.5%), while 9.5% received core decompression surgery and 14.3% underwent total hip replacement. The mean daily dose of prednisolone at diagnosis of osteonecrosis was 8.5mg (range 5-20mg).

This study described the prevalence and epidemiology of osteonecrosis in our cohort of SLE patients.
This study described the prevalence and epidemiology of osteonecrosis in our cohort of SLE patients.
The prevalence of bronchial asthma (BA) is increasing in the Kingdom of Saudi Arabia. The knowledge and adherence to guidelines by physicians can play a major role in controlling asthma.

To assess the knowledge and practice of family medicine and internal medicine physicians about BAat King Saudi University medical city in Riyadh, Kingdom of Saudi Arabia.

A cross-sectional survey study was conducted. All family and internal medicine physicians at King Khalid University Hospital were included. A total of 180 physicians participated. The questionnaire was developed according to the Global Initiative for Asthma (GINA) guideline to assess the knowledge and practice of physicians towards bronchial asthma, included questions (diagnosis, severity classification, management, and referral).

All participated physicians knowledge and practice level about BAwaslow; the average scores were around 50%. The comparison between family and internal medicine physicians' knowledge shows insignificant differences. The only exception is the management part; family medicine physicians show better results than internal medicine physicians. The years of experience and higher qualification show significant improvement in the level of the knowledge scores.

The knowledge of physicians about the diagnosis, assessment of severity, management, and referral of BA was unsatisfactory. https://www.selleckchem.com/products/danirixin.html We recommend an adoption of a special asthma clinic for teaching, supervising, and managing purposes assigned to an expert consultant.
The knowledge of physicians about the diagnosis, assessment of severity, management, and referral of BA was unsatisfactory. We recommend an adoption of a special asthma clinic for teaching, supervising, and managing purposes assigned to an expert consultant.
A child usually takes up the behavioural habits by observing the parents at home. The mapping of the current level of influence of parents' practices over children is necessary for developing any preventive programs therefore the aim of the study was to determine the influence of familial oral health habits on the adolescent children belonging to rural background.

The present cross-sectional questionnaire study was conducted on 236 rural participants (parents and their children) reporting to a private dental college in a rural set up in India. Questions on demographics, oral hygiene habits and oral health knowledge were asked. Chi-square test and unpaired 't' test was used to determine the differences between parents and children. The cut-off point was set at (0.05).

A total of 95 parents considered themselves having good oral health, majority of their children (
= 74; 77.9%) matched their perception. Most of the parents (
= 124) and children (
= 108) reported to dentist only in case of any dental problem. Maximum participant, 85.6% parents and 81.4% children brushed their teeth once a day. Mean knowledge score were higher in children (11.06 ± 2.68) and difference was statistically significant (
< 0.05). Most children (74.6%) learned to brush from their mother followed by father (10.2%).

Correct knowledge regarding good oral hygiene practices should be rendered to the parents so that they will successfully transfer these habits to their youngsters.
Correct knowledge regarding good oral hygiene practices should be rendered to the parents so that they will successfully transfer these habits to their youngsters.
This study investigated the factors affecting the acceptance of hospital electronic health record (EHR) adoption by users based on Technology Acceptance Model3 (TAM3).

The self-administered TAM3 questionnaire was used for data gathering. Content validity and reliability of the TAM3 questionnaire were measured. The relation between dependent, independent, and mediator variables was analyzed using multiple regression analysis.

The results from 224 users indicated that subjective norm, job relevance, output quality, voluntariness, computer experience have significant impacts on perceived usefulness. Also, perceptions of external control and computer anxiety were identified as having significant impacts on perceived ease of use. Perceived usefulness did not have a mediator role between result demonstrability and behavioral intention. Perceived ease of use was not found to be a mediating factor in the relationship between computer self- efficacy and behavioral intention, as well as perceived enjoyment.

The findings of the current study, provide valuable scientific evidence for key affecting factors on hospital EHR in Iran as a developing country. Our results showed the main constructs and relationships depicted in the TAM3 were found to be applicable to assess the adoption of hospital EHR.
The findings of the current study, provide valuable scientific evidence for key affecting factors on hospital EHR in Iran as a developing country. Our results showed the main constructs and relationships depicted in the TAM3 were found to be applicable to assess the adoption of hospital EHR.
Pulmonary thromboembolism is the third most common vascular disease after coronary heart disease and stroke and is approximately 10 times more common in pregnant women compared with the nonpregnant population at the same age. The purpose of the current work is to evaluate D-dimer plasma concentration in pregnant women with or without pulmonary thromboembolism.

The present study was a cross-sectional study in which 100 pregnant women with suspected pulmonary embolism referred to Imam Khomeini Hospital in Ahwaz in 1398 were studied. After imaging and approving or rejecting a pulmonary embolism, simultaneously the D-dimer sample was taken from them; then the dimer level in each trimester was compared in positive or negative cases of pulmonary embolism. The SPSS software version 22 was used for data analysis.

The results showed that 12 patients in the study population had pulmonary embolism and 88 patients did not have pulmonary embolism. According to the results of patients with pulmonary embolism based on CT angiography results, there was no significant relationship with increasing gestational age and mean dimer level (
= 0.

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Today on “Truth in Media”, the situation in Syria continues to deteriorate. It looks like an all-out war is in the making.

Militants have fanned out from the northern city of Aleppo and renewed their offensive. Meanwhile, the U.S. is conducting airstrikes against the Syrian government and allied forces.

Russia is also taking the battle to the air in support of its ally Syria, as tens of thousands of Iraqi Shia soldiers have entered the country to aid President Assad’s embattled forces.

So, are we heading to World War III officially? When will these proxy wars spill out into a full-fledged war pitting the West against Russia, Iran, and its allies?

https://www.thelastamericanvagabond.com/georgia-dioxin-iran-amsterdam-gaza/

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Today on “Truth in Media”, the situation in Syria continues to deteriorate. It looks like an all-out war is in the making.

Militants have fanned out from the northern city of Aleppo and renewed their offensive. Meanwhile, the U.S. is conducting airstrikes against the Syrian government and allied forces.

Russia is also taking the battle to the air in support of its ally Syria, as tens of thousands of Iraqi Shia soldiers have entered the country to aid President Assad’s embattled forces.

So, are we heading to World War III officially? When will these proxy wars spill out into a full-fledged war pitting the West against Russia, Iran, and its allies?

https://www.thelastamericanvagabond.com/georgia-dioxin-iran-amsterdam-gaza/

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In this episode of Direct Impact, Rick Sanchez tackles the rising tensions in the Middle East, highlighting how the US is bolstering its military presence and financial support for Israel while advising against any Iranian retaliation. Shifting focus to the US presidential race, Rick delves into Kamala Harris’s reserved campaign strategy and Donald Trump’s erratic behavior, including his bizarre preoccupation with crowd sizes and dubious claims about his opponents. The show wraps up with an insightful interview with trends expert Gerald Celente, who shares his perspective on the current state of the election and what might lie ahead.

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4 hrs ago


Although coronavirus disease 2019 (COVID-19) is a mild infection in most children, a small proportion develop severe or critical illness. Data describing agents with potential antiviral activity continue to expand such that updated guidance is needed regarding use of these agents in children.

A panel of pediatric infectious diseases physicians and pharmacists from 20 geographically diverse North American institutions was convened. Through a series of teleconferences and web-based surveys, a set of guidance statements was developed and refined based on review of the best available evidence and expert opinion.

Given the typically mild course of COVID-19 in children, supportive care alone is suggested for most cases. For children with severe illness, defined as a supplemental oxygen requirement without need for noninvasive or invasive mechanical ventilation or extracorporeal membrane oxygenation (ECMO), remdesivir is suggested, preferably as part of a clinical trial if available. Remdesivir should also be considered for critically ill children requiring invasive or noninvasive mechanical ventilation or ECMO. A duration of 5 days is appropriate for most patients. The panel recommends against the use of hydroxychloroquine or lopinavir-ritonavir (or other protease inhibitors) for COVID-19 in children.

Antiviral therapy for COVID-19 is not necessary for the great majority of pediatric patients. For children with severe or critical disease, this guidance offers an approach for decision-making regarding use of remdesivir.
Antiviral therapy for COVID-19 is not necessary for the great majority of pediatric patients. For children with severe or critical disease, this guidance offers an approach for decision-making regarding use of remdesivir.The cabbage aphid, Brevicoryne brassicae (L.), is one of the major insect pests of cole crops in Iran. In most instances outbreaks are normally kept under control by application of insecticides. In this study, the sublethal effects (LC30) of three insecticides, acetamiprid, buprofezin, and thiamethoxam-lambda cyhalothrin, (TLC) were evaluated on the population growth rate of the progeny of insecticide-treated cabbage aphid adults. The age-stage, two-sex life table method was used to analyze the collected data. The results indicated that the insecticide applications affected the duration of the preadult period, their survival, reproduction, life span/longevity, and consequently, the population growth rate of the F1 generation. The indicators of the greatest sublethal effects were noted in the progeny of the TLC-treated adults. These included the lowest net reproductive rate (R0), intrinsic rate of increase (r), finite rate of increase (λ), and the longest mean generation time (T). https://www.selleckchem.com/products/az32.html The highest values of r, λ, R, and the lowest value of T occurred in the control group followed by, in order, the acetamiprid and buprofezin groups. These research findings will be useful in the development and implementation of future aphid management programs.
The purpose of this explanatory case study is to explain the implementation of interprofessional, multitiered lean daily management (LDM) and to quantitatively report its impact on hospital safety.

This case study explained the framework for LDM implementation and changes in quality metrics associated with the interprofessional, multitiered LDM, implemented at Saint Francis Hospital and Medical Center (SFHMC) at the end of 2018. Concepts from lean, Total Quality Management (TQM) and high reliability science were applied to develop the four tiers and
rounding components of LDM. A two-tailed
-test analysis was utilized to determine statistical significance for serious safety events (SSEs) comparing the intervention period (January 2019-December 2019) to the baseline period (calendar years 2017 and 2018). Other quality and efficiency metrics were also tracked.

LDM was associated with decreased SSEs in 2019 compared to 2017 and 2018 (
≤0.01). There were no reportable central line-associated blood stre any significant capital or other investment.

As hospital systems move from a volume-based to value-based health-care delivery model, dynamic interventions using LDM can play a pivotal role in helping all patients, particularly in underserved settings where lower cost care is required for sustainability, given limited available resources.

While many hospital systems promote organizational rounding as a routine quality improvement process, this study shows that a dynamic, intense LDM model can dramatically improve safety within months. This was done in a challenging urban environment for a high-acuity population with limited resources.
While many hospital systems promote organizational rounding as a routine quality improvement process, this study shows that a dynamic, intense LDM model can dramatically improve safety within months. This was done in a challenging urban environment for a high-acuity population with limited resources.
Proline availability for proline dehydrogenase/proline oxidase (PRODH/POX) may represent switching mechanism between PRODH/POX-dependent apoptosis and autophagy. The aim of the study was to evaluate the impact of overexpression of prolidase (proline releasing enzyme) on apoptosis/autophagy in breast cancer MCF-7 cells.

The model of MCF-7 cells with prolidase overexpression (MCF-7
) was obtained. In order to targeting proline for PRODH/POX-dependent pathways substrate for prolidase, glycyl-proline (GP) was provided and proline utilization for collagen biosynthesis was blocked using 2-methoxyestradiol (MOE). Cell viability was determined using Nucleo-Counter NC-3000. The activity of prolidase was determined by colorimetric assay. DNA, collagen and total protein biosynthesis were determined by radiometric method. Expression of proteins was assessed by Western blot and immunofluorescence bioimaging. Concentration of proline was analyzed by liquid chromatography with mass spectrometry.

Prolidase overexpressF-7 cells contributes to increase in intracellular proline concentration and PRODH/POX-dependent autophagic cell death.
GNB1 encodes a subunit of a heterotrimeric G-protein complex that transduces intracellular signaling cascades. Disruptions to the gene have previously been shown to be embryonic lethal in knockout mice and to cause complex neurodevelopmental disorders in humans. To date, the majority of variants associated with disease in humans have been missense variants in exons 5-7.

Genetic sequencing was performed on two patients presenting with complex neurological phenotypes including intellectual disability, hypotonia, and in one patient seizures. Reported variants were assessed using RNA sequencing and functional BRET/BiFC assays.

A splice variant reported in patient 1 was confirmed to cause usage of a cryptic splice site leading to a truncated protein product. Patient 2 was reported to have a truncating variant. BRET and BiFC assays of both patient variants confirmed both were deficient in inducing GPCR-induced G protein activation due to lack of dimer formation with the Gγ subunit.

Here, we report two patients with functionally confirmed loss of function variants in GNB1 and neurodevelopmental phenotypes including intellectual disability, hypotonia, and seizures in one patient.

4 hrs ago


Snapdragon (Antirrhinum majus L.) flowers are one of the most frequently used edible flowers in different preparations of foods and drinks. https://www.selleckchem.com/products/pitstop-2.html In this study, we examined inhibitory effects of snapdragon flower extract (SFE) against distinctive properties of cancer cells, stimulated growth, and activated metastasis, using H1299 lung cancer and HCT116 colon cancer cell lines. SFE treatment at 100-1,000 μg/ml for 24-72 hr resulted in a time- and dose-dependent growth inhibition in H1299 and HCT116 cells. Cell cycle analysis and Annexin V staining assay further revealed that SFE caused cell cycle arrest at G2/M phase and induction of apoptosis, indicating the growth inhibition by SFE is attributed to its G2/M cell cycle-arresting and apoptosis-inducing activities. SFE dose-dependently enhanced generation of intracellular reactive oxygen species (ROS) and reduced mitochondrial membrane potential in H1299 cells but had no effect on intracellular ROS levels in HCT116 cells, suggesting that the type of apoptosis induced by SFE in H1299 cells is different to that in HCT116 cells. Furthermore, SFE alleviated invasion, levels of matrix metalloproteinases, migration, and adhesion in H1299 and HCT116 cells. These results indicate that SFE not only inhibits cell growth by cell cycle arrest at G2/M and apoptosis induction but also alleviates metastatic properties such as invasion, migration, and adhesion in lung and colon cancer cells.This paper reports the effects of four popular cooking methods viz. grilling, boiling, frying, and microwaving on the proximate and nutritional compositions of freshwater mud eel (FWME) muscle. The moisture content of raw FWME muscle was 74.45%, which was similar in boiled products but lower in grilled, fried, and microwaved products (p ≤ .05). The protein content in raw and cooked FWME muscles varied between 14.49% and 21.28%. There were found 20 different fatty acids in FWME muscle of which palmitic acid was the most abundant one with an amount of 26.51%-29.70% in raw and cooked FWME muscles. FWME muscle contained a substantial amount of ω-3 polyunsaturated fatty acids, ranging from 7.54% to 13.7%. However, the thermal effects during cooking decreased the ω-3 polyunsaturated fatty acid contents. There were seven essential and eight nonessential amino acids available in FWME muscle; among the essential amino acids, lysine content was the highest. Raw and cooked FWME were very rich in calcium, between 794.52 mg/100 g and 883.24 mg/100 g muscle. Among the studied heavy metals, Pb content was the highest. However, all the heavy metal contents were within acceptable limits determined by health risk assessment, that is, target hazard quotient and target cancer risk.This study aimed to develop biscuits with improved nutritional contents using edible fish meal from catfish as the source of macro- and micronutrient enrichment while trying to reduce the input of wheat flour in biscuit-making process. The biscuit was produced using edible fish meal (EFM 0%-40%) from catfish, improved quality breadfruit (IQBF 0%-60%), and wheat flours (WF 0%-40%). Macro (crude protein, fat, fiber, ash, and carbohydrate)- and micro (calcium, magnesium, potassium, phosphorus, sodium, and iron)-nutrient contents of the biscuit were determined. The color (lightness-L*, redness-a*, and yellowness-b*), texture (hardness, springiness, and adhesiveness), and sensory (taste, texture, and overall acceptability) attributes of the biscuits were assessed using standard methods. Model characteristics of the responses were profiled, and numerical optimization technique was used to predict combination/blends that produce biscuits with desired nutritional contents. Moisture, crude protein, fat, fiber, and ash values were in the range of 3.50%-5.57%, 3.06%-15.52%, 13.62%-26.00%, 0.31%-1.40%, and 1.98%-5.32%, respectively. The iron, calcium, and phosphorus contents of the biscuit ranged from 103.85 to 201.30 mg/100 g, 100 to 754 mg/100 g, and 8 mg/100 g to 304 mg/100 g, respectively. Interaction between the models for WF and EFM was significant and this significantly affected the L* (36.37-51.90) and adhesiveness (0.01-0.29) values for color and texture, respectively. Similar observations were also noticed for most of the nutrients. The quadratic models selected for the nutrients were all significant (p less then .05) and the adjusted R2 ranged from 0.61 to 0.84 and 0.59 to 0.97 for the macro- and micronutrients, respectively. In conclusion, a biscuit from IQBF, WF, and EFM of 61.33, 0.07, and 38.60 with protein, fat, ash, iron, and calcium contents of 10.41%, 17.59%, 2.05%, 120.52 mg/100 g, and 500.00 mg/100 g, respectively, was produced.
Central obesity, insulin resistance, dyslipidemia, and hypertension are the core components of metabolic syndrome (MetS) which is coincident with unhealthy dietary habits in the Middle-Eastern countries. The aim of this study was to explore the association between dietary habits and MetS of the adult population living in Yazd Greater Area, Iran.

This is a cross-sectional study that uses the data of a population-based cohort study on Iranian adults, known as Yazd Health Study (YaHS). The relationship between dietary habits and metabolic syndrome among adults (
=2,896) was analyzed using multiple logistic regression method.

The prevalence of MetS among the participants was 32.2%. Outcomes from logistic regression examination show that breakfast consumption has a significant inverse effect on the occurrence of MetS after adjustment for age, education level, physical activity statue, history of chronic diseases, and smoking (odds ratio (OR)=0.38, 95% confidence interval (CI)=0.14, 0.97). This effect remains significant even after adjustment for body mass index (BMI) and reveals that odds of having MetS is 69% lower in breakfast consumers in contrast to nonconsumers (OR=0.31, 95% CI=0.11, 0.87). However, no significant relationship was observed between other dietary habits including consumption of sweetened drinks, sugar cubes, and fast foods and MetS after adjustment for all potential confounders.

This study revealed that eating breakfast has an inverse relationship with metabolic syndrome. To find out stronger evidence in relation to dietary habits and MetS, more researches especially population-based cohort studies are needed to be conducted.
This study revealed that eating breakfast has an inverse relationship with metabolic syndrome. To find out stronger evidence in relation to dietary habits and MetS, more researches especially population-based cohort studies are needed to be conducted.

4 hrs ago


7% were the associated comorbidities. The most common stage by imaging at diagnosis was stage IV (38%), followed by 24% stage V, 19% stage III and 9.5% stage II and 9.5% stage VI. Medical management include bisphosphonates (100%), statins (90.4%) and anticoagulant therapy (28.5%), while 9.5% received core decompression surgery and 14.3% underwent total hip replacement. The mean daily dose of prednisolone at diagnosis of osteonecrosis was 8.5mg (range 5-20mg).

This study described the prevalence and epidemiology of osteonecrosis in our cohort of SLE patients.
This study described the prevalence and epidemiology of osteonecrosis in our cohort of SLE patients.
The prevalence of bronchial asthma (BA) is increasing in the Kingdom of Saudi Arabia. The knowledge and adherence to guidelines by physicians can play a major role in controlling asthma.

To assess the knowledge and practice of family medicine and internal medicine physicians about BAat King Saudi University medical city in Riyadh, Kingdom of Saudi Arabia.

A cross-sectional survey study was conducted. All family and internal medicine physicians at King Khalid University Hospital were included. A total of 180 physicians participated. The questionnaire was developed according to the Global Initiative for Asthma (GINA) guideline to assess the knowledge and practice of physicians towards bronchial asthma, included questions (diagnosis, severity classification, management, and referral).

All participated physicians knowledge and practice level about BAwaslow; the average scores were around 50%. The comparison between family and internal medicine physicians' knowledge shows insignificant differences. The only exception is the management part; family medicine physicians show better results than internal medicine physicians. The years of experience and higher qualification show significant improvement in the level of the knowledge scores.

The knowledge of physicians about the diagnosis, assessment of severity, management, and referral of BA was unsatisfactory. https://www.selleckchem.com/products/danirixin.html We recommend an adoption of a special asthma clinic for teaching, supervising, and managing purposes assigned to an expert consultant.
The knowledge of physicians about the diagnosis, assessment of severity, management, and referral of BA was unsatisfactory. We recommend an adoption of a special asthma clinic for teaching, supervising, and managing purposes assigned to an expert consultant.
A child usually takes up the behavioural habits by observing the parents at home. The mapping of the current level of influence of parents' practices over children is necessary for developing any preventive programs therefore the aim of the study was to determine the influence of familial oral health habits on the adolescent children belonging to rural background.

The present cross-sectional questionnaire study was conducted on 236 rural participants (parents and their children) reporting to a private dental college in a rural set up in India. Questions on demographics, oral hygiene habits and oral health knowledge were asked. Chi-square test and unpaired 't' test was used to determine the differences between parents and children. The cut-off point was set at (0.05).

A total of 95 parents considered themselves having good oral health, majority of their children (
= 74; 77.9%) matched their perception. Most of the parents (
= 124) and children (
= 108) reported to dentist only in case of any dental problem. Maximum participant, 85.6% parents and 81.4% children brushed their teeth once a day. Mean knowledge score were higher in children (11.06 ± 2.68) and difference was statistically significant (
< 0.05). Most children (74.6%) learned to brush from their mother followed by father (10.2%).

Correct knowledge regarding good oral hygiene practices should be rendered to the parents so that they will successfully transfer these habits to their youngsters.
Correct knowledge regarding good oral hygiene practices should be rendered to the parents so that they will successfully transfer these habits to their youngsters.
This study investigated the factors affecting the acceptance of hospital electronic health record (EHR) adoption by users based on Technology Acceptance Model3 (TAM3).

The self-administered TAM3 questionnaire was used for data gathering. Content validity and reliability of the TAM3 questionnaire were measured. The relation between dependent, independent, and mediator variables was analyzed using multiple regression analysis.

The results from 224 users indicated that subjective norm, job relevance, output quality, voluntariness, computer experience have significant impacts on perceived usefulness. Also, perceptions of external control and computer anxiety were identified as having significant impacts on perceived ease of use. Perceived usefulness did not have a mediator role between result demonstrability and behavioral intention. Perceived ease of use was not found to be a mediating factor in the relationship between computer self- efficacy and behavioral intention, as well as perceived enjoyment.

The findings of the current study, provide valuable scientific evidence for key affecting factors on hospital EHR in Iran as a developing country. Our results showed the main constructs and relationships depicted in the TAM3 were found to be applicable to assess the adoption of hospital EHR.
The findings of the current study, provide valuable scientific evidence for key affecting factors on hospital EHR in Iran as a developing country. Our results showed the main constructs and relationships depicted in the TAM3 were found to be applicable to assess the adoption of hospital EHR.
Pulmonary thromboembolism is the third most common vascular disease after coronary heart disease and stroke and is approximately 10 times more common in pregnant women compared with the nonpregnant population at the same age. The purpose of the current work is to evaluate D-dimer plasma concentration in pregnant women with or without pulmonary thromboembolism.

The present study was a cross-sectional study in which 100 pregnant women with suspected pulmonary embolism referred to Imam Khomeini Hospital in Ahwaz in 1398 were studied. After imaging and approving or rejecting a pulmonary embolism, simultaneously the D-dimer sample was taken from them; then the dimer level in each trimester was compared in positive or negative cases of pulmonary embolism. The SPSS software version 22 was used for data analysis.

The results showed that 12 patients in the study population had pulmonary embolism and 88 patients did not have pulmonary embolism. According to the results of patients with pulmonary embolism based on CT angiography results, there was no significant relationship with increasing gestational age and mean dimer level (
= 0.

4 hrs ago


The southwest Brazilian Amazon state of Rondônia has a relatively recent non-indigenous occupation, which subsequently develops a variety of human pressures and conflicts of interest presently identified in the region. Given such framework, it is worthwhile to note that there are 57 Conservation Units that must guarantee the biodiversity protection of Amazonia biome. However, due to the need for electricity and the international high demand for minerals, the highlighted scenario has dramatically changed in recent years. Official data from mining processes in the studied area demonstrated the existence of high interest for minerals, especially cassiterite and gold. Mining is indeed an essential activity for the nation mainly due to the generation of jobs and income. On the other hand, it produces several environmental and social impacts that vary accordingly to the peculiarities of the mining and with respect to the type of ore. Therefore, this research work investigated the concentration of mining projects ino be very efficient since it predicted high values over Conservation Units where it was expected a greater vulnerability. The index is a promising tool for public policy formulation and management of protected areas, as well as for enforcement action. The results provide a new horizon in terms of the perspective of importance and applicability of geotechnologies in the evaluation of environmental impacts, not restricted to mining activity. Yearly, in Europe, more than 1 million tonnes of plastic materials are used in agricultural activities. Among the possible applications, plastic films for protected cultivation practices are highly used worldwide because of the significant advantage deriving from the shortening of the growing period. However, in the absence of a correct policy disposal of plastic films, environmental degradation could take place with serious ecological and economic consequences. https://www.selleckchem.com/products/alizarin-red-s.html In this study, a geographical information system (GIS) - based model to locate and quantify the yearly amount of agricultural plastic waste (APW) coming from crop-shelter coverage used in greenhouses system was put forward and was applied in a study area located in southern Italy, highly characterised by protected cultivation practices. Firstly, the areas with the highest density of crop shelters were mapped, then a suitable index to determine APW amount was computed and applied to obtain heat maps related to covering plastic films. Finally, sensitivity analyses were carried out by varying thickness, lifetime, and density of the covering films of the greenhouses, located in the considered samples. The index ranged between 976 kg ha-1yr-1and, 2484 kg ha-1yr-1. The results showed that the density of greenhouses and tunnels-greenhouses is still elevated nearby the coastline, highlighting that the guidelines of the territorial plan of the Province of Ragusa concerning the displacement of protected crops from the coast to the internal rural areas were disregarded. Moreover, the GIS-based model results could provide basic information for the analysis of the environmental impact due to transportation of APW. Therefore, these results could offer a suitable tool to improve the correct disposal management of covering plastic films and the related recycle policy. The purpose of the present study was to explore the power of the Health Belief Model (HBM) to explain water conservation behavior in Northeastern Iran. The research population consisted of farmers who were farming in Neyshabur plain in Khorasan Razavi Province in northeast of Iran. A cross-sectional study was conducted among 235 farmers recruited using a multistage random sampling design. To collect data, the questionnaire was used which its validity and reliability were confirmed. The results of a structural equation modeling (SEM) indicated that perceived susceptibility, perceived benefits, and cue to action accounted for approximately 41% of the variance in farmers' water conservation behavior. Moreover, the perceived benefit was the strongest predictor of water conservation behavior, while perceived severity, perceived barriers, self-efficacy, and general beliefs not significant on behavior. These results confirmed the practicability and effectiveness HBM for examining water conservation behavior among farmers in Iran. The aim of this study was to evaluate the microbial structure and phylogenetic diversity under the influence of nutritional conditions and hydraulic retention time (HRT) in fluidized bed reactors (FBR), operated in short HRT (8 h - FBR8; 12 h - FBR12) for linear alkylbenzene sulfonate (LAS) removal from laundry wastewater. After each phase, biofilm samples from FBR8 and FBR12 were submitted to microbial sequencing by Mi-Seq Illumina®. Higher LAS removal rates were observed after 313 days, achieving 99 ± 3% in FBR12 (22.5 ± 5.9 mg LAS/L affluent) and 93 ± 12% in FBR8 (20.6 ± 4.4 mg LAS/L affluent). Different modifications involving genera of bacteria were observed throughout the reactors operation. The identified microorganisms were, mostly, related to LAS degradation and nitrogen conversion such as Dechloromonas, Flavobacterium, Pseudomonas, and Zoogloea. This review critically examined the existing technologies for the treatment of sulfolane, which is an emerging groundwater contaminant. In general, sulfolane plumes are difficult to contain and mitigate because sulfolane is highly mobile and does not biodegrade to an appreciable extent under anoxic conditions typical of many subsurface environments. Several studies have shown that sulfolane biodegradation can be enhanced in the presence of oxygen, suggesting that in situ biosparging or ex-situ (i.e., pump and treat) aerobic biodegradation can potentially be effective means of remediating sulfolane-contaminated sites. While highly reactive species such as SO4•- and •OH radicals have been shown to oxidize sulfolane, whether sulfolane can be effectively treated by ex situ advanced oxidation processes (AOPs) or by in situ chemical oxidation (ISCO) needs to be further examined. Besides chemical and biological treatments, pump and treat by adsorption on granular activated carbon (GAC) has been applied to remove sulfolane at several sites.

4 hrs ago


Further RSFC feature analysis indicated that the connection strength between frontal and parietal cortices was stronger in the optimal versus the suboptimal weight loss group. These findings show that specific RSFC patterns could be used as neuroimaging biomarkers to predict individual weight loss post-surgery and assist in personalized diagnosis for treatment of obesity.The latest COVID-19 pandemic reveals that unexpected changes elevate depression bringing people apart, but also calling for social sharing. Yet the impact of depression on social cognition and functioning is not well understood. Assessment of social cognition is crucial not only for a better understanding of major depressive disorder (MDD), but also for screening, intervention, and remediation. Here by applying a novel experimental tool, a Face-n-Food task comprising a set of images bordering on the Giuseppe Arcimboldo style, we assessed the face tuning in patients with MDD and person-by-person matched controls. The key benefit of these images is that single components do not trigger face processing. Contrary to common beliefs, the outcome indicates that individuals with depression express intact face responsiveness. Yet, while in depression face sensitivity is tied with perceptual organization, in typical development, it is knotted with social cognition capabilities. Face tuning in depression, therefore, may rely upon altered behavioral strategies and underwriting brain mechanisms. To exclude a possible camouflaging effect of female social skills, we examined gender impact. Neither in depression nor in typical individuals had females excelled in face tuning. The outcome sheds light on the origins of the face sensitivity and alterations in social functioning in depression and mental well-being at large. Aberrant social functioning in depression is likely to be the result of deeply-rooted maladaptive strategies rather than of poor sensitivity to social signals. This has implications for mental well-being under the current pandemic conditions.The prevalent new user design includes a broader study population than the traditional new user approach that is frequently used in pharmacoepidemiologic research. In an article appearing in this issue (Am J Epidemiol. XXXX;XXX(XX)XXXX-XXXX), Webster-Clark and colleagues describe the treatment initiator types included in the prevalent new user design and contrast the causal questions assessed using a prevalent new user design versus a new user design. They further applied a series of simulation studies showing the importance of accounting for treatment history in addition to time since initiation of the comparator in the prevalent new user design. In this commentary, we put their findings in the broader context with a discussion of the strengths and limitations of the prevalent new user design and settings where it may be most useful. The prevalent new user design and new user design both address unique questions of clinical and public health importance. Real-world evidence generated by pharmacoepidemiologic research is increasingly being used by regulators and other knowledge users to inform their decision making. Understanding the causal questions addressed by different designs is crucial in this process; the study by Webster-Clark and colleagues represents an important step in addressing this issue.Rostro-caudal specificity of corticospinal tract (CST) projections from different areas of the cortex was assessed by retrograde labeling with fluorogold and retrograde transfection following retro-AAV/Cre injection into the spinal cord of tdT reporter mice. Injections at C5 led to retrograde labeling of neurons throughout forelimb area of the sensorimotor cortex and a region in the dorsolateral cortex near the barrel field (S2). Injections at L2 led to retrograde labeling of neurons in the posterior sensorimotor cortex (hindlimb area) but not the dorsolateral cortex. With injections of biotinylated dextran amine (BDA) into the main sensorimotor cortex (forelimb region), labeled axons terminated selectively at cervical levels. With BDA injections into caudal sensorimotor cortex (hindlimb region), labeled axons passed through cervical levels without sending collaterals into the gray matter and then elaborated terminal arbors at thoracic sacral levels. With BDA injections into the dorsolateral cortex near the barrel field, labeled axons terminated at high cervical levels. Axons from medial sensorimotor cortex terminated primarily in intermediate laminae and axons from lateral sensorimotor cortex terminated primarily in laminae III-V of the dorsal horn. One of the descending pathways seen in rats (the ventral CST) was not observed in most mice.This study aimed to estimate causal effect of normalized protein catabolic rate (nPCR) on mortality among end stage renal disease (ESRD) patients in the presence of time-varying confounding affected by prior exposure using g-estimation. Information about 553 ESRD patients was retrospectively collected over 8 years, from 2011 to 2019, from hemodialysis facilities at Kerman, southeast of Iran. https://www.selleckchem.com/products/hrs-4642.html nPCR was dichotomized to less then 1.2 versus ≥ 1.2 g/kg per day. Then standard time-varying accelerated failure time (AFT) Weibull model was built, and results were compared with those generated by g-estimation. After appropriately adjusting for time-varying confounders, weighted g-estimation yielded 78% shorter survival time (95% confidence interval [95% CI] -81% to -73%) in patients under continuous nPCR less then 1.2 than those who had nPCR ≥ 1.2 g/kg per day during the follow-up, though it was 18% (95% CI -57% to +54%) in Weibull model. Moreover, the hazard ratio estimates of 4.56 (95% CI 3.69 to 5.37), and 1.20 (95% CI 0.66 to 2.17) were obtained by weighted g-estimation and Weibull model, respectively. G-estimation indicated that inadequate dietary protein intake characterized by nPCR increases all-cause mortality among ESRD patients, but the Weibull model provided a substantially biased effect estimate towards the null.Among 626 participants of the Men's Lifestyle Validation Study (2011-2013), we evaluated the validity and reproducibility of a self-administered 152-item semiquantitative food frequency questionnaire (SFFQ) using two 7-day dietary records (7DDRs), four automated self-administered 24-hour dietary recalls (ASA24s), four 24-hour urine samples, one doubly-labeled water measurement (repeated in 104 participants), and two fasting blood samples, collected over 15 months. Compared to 7DDRs, SFFQs underestimated energy intake, macronutrients, and sodium intake, but overestimated some micronutrients. The mean of Spearman correlation coefficients was 0.66 (range 0.38 to 0.88) between 46 energy-adjusted nutrients estimated from 7DDRs and the final SFFQ, de-attenuated for within-person variation in the 7DDRs. These deattenuated correlations were similar using ASA24s as the comparison. Relative to biomarkers, SFFQs underestimated energy, sodium, and protein intakes, and the sodiumpotassium ratio. The energy-adjusted correlations between the final SFFQ and the biomarkers were slightly lower than the correlations between the SFFQ and 7DDRs.