People

Sorry, no results were found.

Circles

Sorry, no results were found.

Posts

02/08/2025

Argentinian President Javier Milei has announced that his country will withdraw from the globalist World Health Organization

https://www.naturalnews.com/2025-02-07-argentina-withdraws-from-globalist-world-health-organization.html

Argentinian President Javier Milei has ordered the country’s withdrawal from the World Health Organization (WHO), citing profound differences in health management and the organization’s lack of independence during the Wuhan coronavirus (COVID-19) pandemic that led to extensive and economically damaging lockdowns. This decision aligns with the previous actions of U.S. President Donald Trump, who also […]

www.naturalnews.com

02/07/2025

POWERFUL ANALYSIS: In Directing DOGE To Audit The Pentagon, Trump Has Struck The Heart Of The Globalist Control System https://madmaxworld.tv/watch?id=67a6845f01ef337c05891be2

Alex Jones Does A Deep Dive On The Significance Of This Executive Move & Warns That The Deep State WILL Strike Back

banned.video

02/06/2025


Tocilizumab is one of the newest therapeutic options for the acute respiratory distress syndrome (ARDS) caused by the recently discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) β-coronavirus. Several trials are currently ongoing to assess the efficacy and safety profile of tocilizumab in treating ARDS. In this article, we present the case of a Black patient with acute pneumonia who benefited greatly from tocilizumab, but developed severe prolonged neutropenia. Considering the increasing use of tocilizumab among patients with coronavirus disease 2019 (COVID-19), this case warrants further research regarding the possible adverse hematological effects that need to be monitored in order to prevent secondary infections.We report an improved and scalable synthesis of MIDD0301, a positive GABAA receptor modulator that is under development as oral and inhaled treatments for asthma. In contrast to other benzodiazepines in clinical use, MIDD0301 is a chiral compound that has limited brain absorption. The starting material to generate MIDD0301 is 2-amino-5-bromo-2'-fluorobenzophenone, which has a non-basic nitrogen due to electron withdrawing substituents in the ortho and para positions, reducing its reactivity towards activated carboxylic acids. Investigations of peptide coupling reagents on multigram scale resulted in moderate yields due to incomplete conversions. Secondly, basic conditions used for the formation of the seven-membered 1,4-diazepine ring resulted in racemization of the chiral center. We found that neutral conditions comparable to the pKa of the primary amine were sufficient to support the formation of the intramolecular imine but did not enable the simultaneous removal of the protecting group. Both difficulties were overcome with the application of the N-carboxyanhydride of D-alanine. Activated in the presence of acid, this compound reacted with non-basic 2-amino-5-bromo-2'-fluorobenzophenone and formed the 1,4-diazepine upon neutralization with triethylamine. Carefully designed workup procedures and divergent solubility of the synthetic intermediates in solvents and solvent combinations were utilized to eliminate the need for column chromatography. To improve compatibility with large scale reactors, temperature-controlled slow addition of reagents generated the imidazodiazepine at -20 °C. All intermediates were isolated with a purity of >97% and impurities were identified and quantified. After the final hydrolysis step, MIDD0301 was isolated in a 44% overall yield and purity of 98.9% after recrystallization. The enantiomeric excess was greater than 99.0%.An efficient, scalable, and good manufacturing practice (GMP) compatible process was developed for the production of docetaxel-loaded poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) micelles. First, the synthesis of the mPEG-b-p(HPMA-Bz) block copolymer was optimized through step-by-step investigation of the batch synthesis procedures. This resulted in the production of 1 kg of mPEG-b-p(HPMA-Bz) block copolymer with a 5 kDa PEG block and an overall molecular weight of 22.5 kDa. Second, the reproducibility and scalability of micelle formation was investigated for both batch and continuous flow setups by assessing critical process parameters. This resulted in the development of a new and highly efficient continuous flow process, which led to the production of 100 mL of unloaded micelles with a size of 55 nm. Finally, the loading of the micelles with the anticancer drug docetaxel was successfully fine-tuned to obtain precise control on the loaded micelle characteristics. As a result, 100 mL of docetaxel-loaded micelles (20 mg/mL polymer and 5 mg/mL docetaxel in the feed) with a size of 55 nm, an encapsulation efficiency of 65%, a loading capacity of 14%, and stable for at least 2 months in water at room temperature were produced with the newly developed continuous flow process. In conclusion, this study paves the way for efficient and robust large-scale production of docetaxel-loaded micelles with high encapsulation efficiencies and stability, which is crucial for their applicability as a clinically relevant drug delivery platform.By employing discourse-historical approach and corpus linguistics, this paper examines media reports to analyze the Chinese official discourse in the context of the COVID-19 outbreak. The results demonstrate that a paradox of globalism and nationalism has been simultaneously reflected when reporting the global pandemic. https://www.selleckchem.com/products/paeoniflorin.html Based on a polarizing discursive construction of positive "self" and negative "others," on many occasions, the globalist and nationalist arguments have been closely intertwined and complement each other to reinforce the legitimacy of the ruling party at home and the international reputation of China under the leadership of the ruling party.Following the advent of the COVID-19 pandemic, analysts have noted a global rise of nationalism as countries have engaged in a number of nationalist moves in response to the pandemic. However, the implication of policy changes at the individual-level remains unclear do citizens support those nationalist government responses? More importantly, do people tend to be more nationalistic following the outbreak? Building on terror management theory (TMT), this article examines whether and how ideological beliefs affect individuals' support for nationalist policies during the COVID-19 pandemic. According to TMT, to cope with death anxiety, people are predisposed to ideological defense, resulting in cohesion with individuals who validate their beliefs and hostility toward those who threaten them. Thus, we argue that when states' nationalist policies are aligned with their ideology, people tend to support them; yet, when states' nationalist policies contradict their ideology, people tend to withdraw their support. Specifically, this study found that as non-conservatives (compared to conservatives) are more concerned with the virus, they are more likely to show an inclination of ideological validation. Given that their ideology advocates more tolerance, non-conservatives are less likely to support nationalistic policies. To test the hypotheses, we applied structural equation modeling to a March 2020 CNN Poll (nationally representative US data about COVID-19). The statistical analysis demonstrated strong support for our arguments.

Videos

05/20/2024

Dr. Robert Malone Credits Alex Jones For Never Backing Down After Relentless Globalist Attacks!!!


SUPPORT: https://DrJonesNaturals.com https://infowarsstore.com

06/03/2023

It’s the premiere of “The Great Awakening” in Austin, Texas. This film can and will stop the next phase of the Globalist depopulation plans, including a permanent lockdown.

02/06/2023

There is a war on Free Speech across the globe. The ability to speak your mind freely is under attack. Across the globe from China, to New Zealand and yes even the land of the free, the United States, there is a battle over having your own opinion. Big tech is partnering with big government to silence those who do not tow the party line. To discuss Scottie Nell Hughes is joined by Mila Ghorayeb. She is a law student at the University of British Columbia as well as a journalist and podcast host. 

People

Sorry, no results were found.

Circles

Sorry, no results were found.

Videos

05/20/2024

Dr. Robert Malone Credits Alex Jones For Never Backing Down After Relentless Globalist Attacks!!!


SUPPORT: https://DrJonesNaturals.com https://infowarsstore.com

06/03/2023

It’s the premiere of “The Great Awakening” in Austin, Texas. This film can and will stop the next phase of the Globalist depopulation plans, including a permanent lockdown.

02/06/2023

There is a war on Free Speech across the globe. The ability to speak your mind freely is under attack. Across the globe from China, to New Zealand and yes even the land of the free, the United States, there is a battle over having your own opinion. Big tech is partnering with big government to silence those who do not tow the party line. To discuss Scottie Nell Hughes is joined by Mila Ghorayeb. She is a law student at the University of British Columbia as well as a journalist and podcast host. 

01/02/2023

Brilliant perspective from Russell Brand on the impending WHO Pandemic Treaty, slated to strip every country of its autonomy, democracy and sovereignty with the stroke of a globalist’s pen. WATCH + SHARE to wake up more of our fellow humans!

Learn more → https://bit.ly/3LmZYgn

#StopTheTreaty

Posts

02/08/2025

Argentinian President Javier Milei has announced that his country will withdraw from the globalist World Health Organization

https://www.naturalnews.com/2025-02-07-argentina-withdraws-from-globalist-world-health-organization.html

Argentinian President Javier Milei has ordered the country’s withdrawal from the World Health Organization (WHO), citing profound differences in health management and the organization’s lack of independence during the Wuhan coronavirus (COVID-19) pandemic that led to extensive and economically damaging lockdowns. This decision aligns with the previous actions of U.S. President Donald Trump, who also […]

www.naturalnews.com

02/07/2025

POWERFUL ANALYSIS: In Directing DOGE To Audit The Pentagon, Trump Has Struck The Heart Of The Globalist Control System https://madmaxworld.tv/watch?id=67a6845f01ef337c05891be2

Alex Jones Does A Deep Dive On The Significance Of This Executive Move & Warns That The Deep State WILL Strike Back

banned.video

02/06/2025


Tocilizumab is one of the newest therapeutic options for the acute respiratory distress syndrome (ARDS) caused by the recently discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) β-coronavirus. Several trials are currently ongoing to assess the efficacy and safety profile of tocilizumab in treating ARDS. In this article, we present the case of a Black patient with acute pneumonia who benefited greatly from tocilizumab, but developed severe prolonged neutropenia. Considering the increasing use of tocilizumab among patients with coronavirus disease 2019 (COVID-19), this case warrants further research regarding the possible adverse hematological effects that need to be monitored in order to prevent secondary infections.We report an improved and scalable synthesis of MIDD0301, a positive GABAA receptor modulator that is under development as oral and inhaled treatments for asthma. In contrast to other benzodiazepines in clinical use, MIDD0301 is a chiral compound that has limited brain absorption. The starting material to generate MIDD0301 is 2-amino-5-bromo-2'-fluorobenzophenone, which has a non-basic nitrogen due to electron withdrawing substituents in the ortho and para positions, reducing its reactivity towards activated carboxylic acids. Investigations of peptide coupling reagents on multigram scale resulted in moderate yields due to incomplete conversions. Secondly, basic conditions used for the formation of the seven-membered 1,4-diazepine ring resulted in racemization of the chiral center. We found that neutral conditions comparable to the pKa of the primary amine were sufficient to support the formation of the intramolecular imine but did not enable the simultaneous removal of the protecting group. Both difficulties were overcome with the application of the N-carboxyanhydride of D-alanine. Activated in the presence of acid, this compound reacted with non-basic 2-amino-5-bromo-2'-fluorobenzophenone and formed the 1,4-diazepine upon neutralization with triethylamine. Carefully designed workup procedures and divergent solubility of the synthetic intermediates in solvents and solvent combinations were utilized to eliminate the need for column chromatography. To improve compatibility with large scale reactors, temperature-controlled slow addition of reagents generated the imidazodiazepine at -20 °C. All intermediates were isolated with a purity of >97% and impurities were identified and quantified. After the final hydrolysis step, MIDD0301 was isolated in a 44% overall yield and purity of 98.9% after recrystallization. The enantiomeric excess was greater than 99.0%.An efficient, scalable, and good manufacturing practice (GMP) compatible process was developed for the production of docetaxel-loaded poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) micelles. First, the synthesis of the mPEG-b-p(HPMA-Bz) block copolymer was optimized through step-by-step investigation of the batch synthesis procedures. This resulted in the production of 1 kg of mPEG-b-p(HPMA-Bz) block copolymer with a 5 kDa PEG block and an overall molecular weight of 22.5 kDa. Second, the reproducibility and scalability of micelle formation was investigated for both batch and continuous flow setups by assessing critical process parameters. This resulted in the development of a new and highly efficient continuous flow process, which led to the production of 100 mL of unloaded micelles with a size of 55 nm. Finally, the loading of the micelles with the anticancer drug docetaxel was successfully fine-tuned to obtain precise control on the loaded micelle characteristics. As a result, 100 mL of docetaxel-loaded micelles (20 mg/mL polymer and 5 mg/mL docetaxel in the feed) with a size of 55 nm, an encapsulation efficiency of 65%, a loading capacity of 14%, and stable for at least 2 months in water at room temperature were produced with the newly developed continuous flow process. In conclusion, this study paves the way for efficient and robust large-scale production of docetaxel-loaded micelles with high encapsulation efficiencies and stability, which is crucial for their applicability as a clinically relevant drug delivery platform.By employing discourse-historical approach and corpus linguistics, this paper examines media reports to analyze the Chinese official discourse in the context of the COVID-19 outbreak. The results demonstrate that a paradox of globalism and nationalism has been simultaneously reflected when reporting the global pandemic. https://www.selleckchem.com/products/paeoniflorin.html Based on a polarizing discursive construction of positive "self" and negative "others," on many occasions, the globalist and nationalist arguments have been closely intertwined and complement each other to reinforce the legitimacy of the ruling party at home and the international reputation of China under the leadership of the ruling party.Following the advent of the COVID-19 pandemic, analysts have noted a global rise of nationalism as countries have engaged in a number of nationalist moves in response to the pandemic. However, the implication of policy changes at the individual-level remains unclear do citizens support those nationalist government responses? More importantly, do people tend to be more nationalistic following the outbreak? Building on terror management theory (TMT), this article examines whether and how ideological beliefs affect individuals' support for nationalist policies during the COVID-19 pandemic. According to TMT, to cope with death anxiety, people are predisposed to ideological defense, resulting in cohesion with individuals who validate their beliefs and hostility toward those who threaten them. Thus, we argue that when states' nationalist policies are aligned with their ideology, people tend to support them; yet, when states' nationalist policies contradict their ideology, people tend to withdraw their support. Specifically, this study found that as non-conservatives (compared to conservatives) are more concerned with the virus, they are more likely to show an inclination of ideological validation. Given that their ideology advocates more tolerance, non-conservatives are less likely to support nationalistic policies. To test the hypotheses, we applied structural equation modeling to a March 2020 CNN Poll (nationally representative US data about COVID-19). The statistical analysis demonstrated strong support for our arguments.

02/06/2025

VIDEO: Watch President Trump Drive A Political Stake Through The Heart Of The Globalist Controlled Transgender Death Cult https://madmaxworld.tv/watch?id=67a54e7d2a23988368bb1abd

PLUS, Rep. Nancy Mace Breaks The News That DOGE Has Now Exposed A Federal Program That Spent Over $10 Million To Torture 'Transgender' Animals

banned.video

02/05/2025


Tocilizumab is one of the newest therapeutic options for the acute respiratory distress syndrome (ARDS) caused by the recently discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) β-coronavirus. Several trials are currently ongoing to assess the efficacy and safety profile of tocilizumab in treating ARDS. In this article, we present the case of a Black patient with acute pneumonia who benefited greatly from tocilizumab, but developed severe prolonged neutropenia. Considering the increasing use of tocilizumab among patients with coronavirus disease 2019 (COVID-19), this case warrants further research regarding the possible adverse hematological effects that need to be monitored in order to prevent secondary infections.We report an improved and scalable synthesis of MIDD0301, a positive GABAA receptor modulator that is under development as oral and inhaled treatments for asthma. In contrast to other benzodiazepines in clinical use, MIDD0301 is a chiral compound that has limited brain absorption. The starting material to generate MIDD0301 is 2-amino-5-bromo-2'-fluorobenzophenone, which has a non-basic nitrogen due to electron withdrawing substituents in the ortho and para positions, reducing its reactivity towards activated carboxylic acids. Investigations of peptide coupling reagents on multigram scale resulted in moderate yields due to incomplete conversions. Secondly, basic conditions used for the formation of the seven-membered 1,4-diazepine ring resulted in racemization of the chiral center. We found that neutral conditions comparable to the pKa of the primary amine were sufficient to support the formation of the intramolecular imine but did not enable the simultaneous removal of the protecting group. Both difficulties were overcome with the application of the N-carboxyanhydride of D-alanine. Activated in the presence of acid, this compound reacted with non-basic 2-amino-5-bromo-2'-fluorobenzophenone and formed the 1,4-diazepine upon neutralization with triethylamine. Carefully designed workup procedures and divergent solubility of the synthetic intermediates in solvents and solvent combinations were utilized to eliminate the need for column chromatography. To improve compatibility with large scale reactors, temperature-controlled slow addition of reagents generated the imidazodiazepine at -20 °C. All intermediates were isolated with a purity of >97% and impurities were identified and quantified. After the final hydrolysis step, MIDD0301 was isolated in a 44% overall yield and purity of 98.9% after recrystallization. The enantiomeric excess was greater than 99.0%.An efficient, scalable, and good manufacturing practice (GMP) compatible process was developed for the production of docetaxel-loaded poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) micelles. First, the synthesis of the mPEG-b-p(HPMA-Bz) block copolymer was optimized through step-by-step investigation of the batch synthesis procedures. This resulted in the production of 1 kg of mPEG-b-p(HPMA-Bz) block copolymer with a 5 kDa PEG block and an overall molecular weight of 22.5 kDa. Second, the reproducibility and scalability of micelle formation was investigated for both batch and continuous flow setups by assessing critical process parameters. This resulted in the development of a new and highly efficient continuous flow process, which led to the production of 100 mL of unloaded micelles with a size of 55 nm. Finally, the loading of the micelles with the anticancer drug docetaxel was successfully fine-tuned to obtain precise control on the loaded micelle characteristics. As a result, 100 mL of docetaxel-loaded micelles (20 mg/mL polymer and 5 mg/mL docetaxel in the feed) with a size of 55 nm, an encapsulation efficiency of 65%, a loading capacity of 14%, and stable for at least 2 months in water at room temperature were produced with the newly developed continuous flow process. In conclusion, this study paves the way for efficient and robust large-scale production of docetaxel-loaded micelles with high encapsulation efficiencies and stability, which is crucial for their applicability as a clinically relevant drug delivery platform.By employing discourse-historical approach and corpus linguistics, this paper examines media reports to analyze the Chinese official discourse in the context of the COVID-19 outbreak. The results demonstrate that a paradox of globalism and nationalism has been simultaneously reflected when reporting the global pandemic. Based on a polarizing discursive construction of positive "self" and negative "others," on many occasions, the globalist and nationalist arguments have been closely intertwined and complement each other to reinforce the legitimacy of the ruling party at home and the international reputation of China under the leadership of the ruling party.Following the advent of the COVID-19 pandemic, analysts have noted a global rise of nationalism as countries have engaged in a number of nationalist moves in response to the pandemic. https://www.selleckchem.com/products/Methazolastone.html However, the implication of policy changes at the individual-level remains unclear do citizens support those nationalist government responses? More importantly, do people tend to be more nationalistic following the outbreak? Building on terror management theory (TMT), this article examines whether and how ideological beliefs affect individuals' support for nationalist policies during the COVID-19 pandemic. According to TMT, to cope with death anxiety, people are predisposed to ideological defense, resulting in cohesion with individuals who validate their beliefs and hostility toward those who threaten them. Thus, we argue that when states' nationalist policies are aligned with their ideology, people tend to support them; yet, when states' nationalist policies contradict their ideology, people tend to withdraw their support. Specifically, this study found that as non-conservatives (compared to conservatives) are more concerned with the virus, they are more likely to show an inclination of ideological validation. Given that their ideology advocates more tolerance, non-conservatives are less likely to support nationalistic policies. To test the hypotheses, we applied structural equation modeling to a March 2020 CNN Poll (nationally representative US data about COVID-19). The statistical analysis demonstrated strong support for our arguments.