73 in the test group and 1.19 ± 0.53 in the control group. The mean postmortem peripheral PCO was 1.75 ± 0.92 in the test group and 2.06 ± 0.77 in the control group. Central and peripheral PCO scores were not statistically different between the test and control groups (P = .41 and P = .35, respectively, 2-tailed t test paired 2-sample for means). CONCLUSIONS A new 1-piece hydrophobic acrylic microincision IOL incorporating an ultraviolet-ozone treatment on the posterior surface performed similarly to a commercially available 1-piece hydrophobic acrylic IOL in terms of uveal and capsular biocompatibility in the rabbit model. To our knowledge, this is the first hydrophobic acrylic microincision IOL to demonstrate similar PCO performance when compared with a conventional, commercially available IOL.PURPOSE To examine the effect of teaching experience of supervising surgeons on resident cataract surgery intraoperative complication rates. SETTING Zuckerberg San Francisco General Hospital, Department of Ophthalmology, University of California, San Francisco, California, USA. DESIGN Retrospective chart review METHODS Cataract surgeries performed by UCSF ophthalmology residents from 2010 to 2017 were reviewed. Only cases supervised by anterior segment attendings with more than 10 years post-residency surgical experience were included. Cases were categorized as being supervised by either full-time UCSF teaching attendings or volunteer private practice attendings. Cases were graded as low risk (0 risk factors), intermediate risk (1 risk factor) or high risk (>=2 risk factors) based on 8 pre- and intra-operative risk factors. Complication rates were compared between the two attending groups among varying risk grades. RESULTS Out of 1377 cases, 101 had complications. Among low-risk cases, full-time teaching attendings (25/619=4.04%) had a similar complication rate to volunteer attendings (17/387=4.39%) (OR 0.92; p = 0.79). In intermediate risk cases, full-time teaching attendings (28/195=14.36%) had a slightly worse complication rates than volunteer attendings (10/88=11.36%) (OR 1.63; p = 0.45). High risk cases had the highest complication rates, with full-time teaching attendings' complication rates (16/72=22.22%) somewhat lower than volunteer attendings' (5/16=31.25%) (OR 0.64; p = 0.48). CONCLUSION For low-risk resident-performed cataract surgeries, supervision by full-time faculty and volunteer attendings yield similar complication rates; thus, residency programs may safely recruit volunteer attendings to supervise low-risk cataract surgeries to support resident training. Analysis of higher risk cases was limited by low surgical volume.PURPOSE Evaluate longitudinal power settings for optimally efficient lens fragment removal, using the Centurion machine. SETTING John A. Moran Eye Center Laboratories, University of Utah, Salt Lake City, Utah, USA. DESIGN Experimental study. METHODS Porcine lens nuclei were cut into 2 mm cubes. Experiments were conducted at 100% torsional power; vacuum set at 500 mmHg, aspiration 50 mL/min, and intraocular pressure 110mmHg. We used a 20-degree tip with a 30-degree bevel. Longitudinal power was tested between 20% and 100%. Efficiency (time for fragment removal) and chatter (number of times the fragment bounced from the tip) were measured. RESULTS A linear increase in efficiency was observed from 20% to 100% longitudinal power (R = .9281, slope = -.0271). An efficiency slope change occurred at 60% power, with the largest incremental change in efficiency between 20% and 60% (R = .9756, slope = -.0394) and a lesser change between 60% and 100% (R = .9827, slope = -.0121). Chatter analysis showed minimal events at 20% to 60%, but a significant increase >80% (P = .005). This increase appeared to be incremental (R = .8929). CONCLUSIONS Increasing longitudinal power, with other settings constant, increases efficiency. https://www.selleckchem.com/products/orforglipron-ly3502970.html Greatest efficiency gains were observed between 20% - 60%. At 80% and 100%, chatter events increased significantly. With a goal of recommending optimally efficient settings while minimizing excess energy and chatter, adding 60% of longitudinal power to 100% torsional power was shown to be the best setting to increase efficiency and avoid repulsion in these vacuum and aspiration settings.PURPOSE Several recent studies have demonstrated that selective Rho-associated protein kinase (ROCK) inhibitor decreased apoptosis and promoted migration of both primate and human-cultured corneal endothelial cells (CEC). Our aim was to evaluate whether exposure to ROCK inhibitor will promote human CEC survival in a commercial storage medium. SETTING Edith Wolfson Medical Center, Holon, Israel and Sheba Medical Center, Tel-Hashomer, Israel DESIGN Experimental study METHODS Fragments of human-donor corneo-limbal rings were stored in commercial storage media for one week, half with the addition of 10µM ROCK inhibitor (Y-27632). Evaluation of CEC for early and late apoptosis
ecrosis rates was done using Anti-Human CD166 antibody and flow cytometric double staining analysis of propidium iodide (PI) and Annexin-V. RESULTS CEC demonstrated reduced early apoptosis rate (4.35%±1.07 vs. 12.18%±5.5, p=.026) and reduced late apoptosis
ecrosis rate (5.5%±2.39 vs. 9.43%±2.61, p=.004), compared to control. Subsequently, the number of apoptotic CEC expressing ROCK was significantly lower in cells exposed to ROCK inhibitor compared with cells that were not (19.01±4.17 vs. 30.42±4.27, p less then 0.001). CONCLUSIONS ROCK inhibitor reduced endothelial cell loss in vitro and therefore may be utilized to limit or slow CEC loss in donor corneal tissue during eye banking. This may be a promising new method for promoting future graft survival.PURPOSE To compare the changes in axial length (AL) obtained after cataract surgery by partial coherence interferometry (PCI), swept-source optical coherence tomography (SS-OCT) with the composite method (CM), and SS-OCT with the segmental method (SM). SETTING National Hospital Organization, Tokyo Medical Center, Japan. DESIGN Retrospective case series. METHODS Two hundred and sixty-eight eyes in 139 patients who underwent cataract surgery were included. AL was measured preoperatively and 1 month postoperatively by PCI, SS-OCT with CM, and SS-OCT with SM. RESULTS The mean ALs measured by PCI and SS-OCT with CM decreased significantly from 24.14 ± 1.58 to 24.05 ± 1.58 mm (P less then .001) and from 24.15 ± 1.58 to 24.05 ± 1.59 mm (P less then .001), respectively. The mean differences between the preoperative and postoperative AL were -0.083 ± 0.044 mm (PCI) and -0.096 ± 0.045 mm (SS-OCT with CM), respectively; Bland-Altman analysis revealed fixed bias between the preoperative and postoperative values. The mean preoperative and postoperative ALs measured by SS-OCT with SM were 24.