08/31/2024


Cervical radicular pain (CRP) is a common problem in the adult population. When conservative treatment fails and the severe pain persist, surgical treatment is considered. However, surgery is associated with some serious risks. To reduce these risks, new minimally invasive techniques have been developed, such as percutaneous nucleoplasty. Several studies have shown that percutaneous nucleoplasty is a safe and effective technique for the treatment of CRP, but until now no randomized controlled trials have been conducted that compare percutaneous cervical nucleoplasty (PCN) to anterior cervical discectomy (ACD) in patients with a single-level contained soft-disc herniation.

To compare the effects of PCN and ACD in a group of patients with CRP caused by a single-level contained soft-disc herniation.

A randomized, controlled, multi-center trial.

Medical University Center and local hospitals.

Forty-eight patients with CRP as a result of a single-level contained soft-disc herniation were randomized to onen arm pain reduction than the PCN group in patients with CRP as a result of a single-level contained soft-disc hernia. However, the clinical relevancy of this treatment effect can be debated. For all parameters, after one year, no significant differences between the groups were found. When it comes to the longer-term effectiveness, we conclude that PCN can be a good alternative for ACD.
Neuropathic facial pain occurs due to pathologic dysfunctions of a nerve responsible for mediating sensory fibers to the head. Surgical interventions, in cases of failed medical therapy, include microvascular decompression, radiofrequency (RF) ablation, percutaneous balloon decompression, and stereotactic radiosurgery. In this review, we focused on RF ablation as a treatment for chronic facial pain.

The objective of this review was to summarize available evidence behind RF ablation for facial pain, including pain outcome measures, secondary outcomes, and complications.

Systematic review.

This systematic review examined studies that applied the use of RF ablation for management of facial pain.

This systematic review was reported following the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Two reviewers independently scored the methodological quality of the selected studies. Due to heterogeneity of studies, a best-evidence synthesis of the availh facial pain, as well as in improving quality of life and reducing oral medication use. Maximal pain control is achieved using combined CRF and PRF therapy. Complications are uncommon and include facial numbness, masseter weakness, cheek hematomas, diminished corneal reflex, and dry eyes.
This systematic review found evidence that RF ablation is efficient in treating patients with facial pain, as well as in improving quality of life and reducing oral medication use. Maximal pain control is achieved using combined CRF and PRF therapy. Complications are uncommon and include facial numbness, masseter weakness, cheek hematomas, diminished corneal reflex, and dry eyes.
Postherpetic neuralgia (PHN) is a neuropathic pain that causes a reduction in patients' quality of life. There are many topical drugs for PHN, including topical lidocaine patch, topical application of capsaicin, and others.

This study aims to compare the efficacy and safety of topical drugs for PHN.

Relevant studies were found by systemically searching for terms including "topical" and "Postherpetic neuralgia" in PubMed, Cochrane library, MEDLINE, and EMBASE databases (inception through June 12, 2019). https://www.selleckchem.com/products/tak-875.html The primary outcome was the percentage of change in the Numeric Rating Scale or the Visual Analog Scale scores from baseline. The secondary outcome was the number of adverse events.

The efficacy and safety of topical drugs for PHN was investigated by the pairwise meta-analysis and Bayesian network meta-analysis, applying Revman 5.3, the Stata 14.0 software, and GeMTC 0.14.3.

Twelve studies met the inclusion criteria, and eligible studies were selected for the ultimate meta-analysis. Our meta-analysis nsistency factors cannot be calculated, and node-splitting method cannot be performed in our network meta-analysis to check the inconsistency.

Compared with other topical drugs, lidocaine was the most effective and most tolerable drug to be recommended for PHN.
Compared with other topical drugs, lidocaine was the most effective and most tolerable drug to be recommended for PHN.
Research into cervical spinal pain syndromes has indicated that the cervical facet joints can be a potent source of neck pain, headache, and referred pain into the upper extremities. There have been multiple diagnostic accuracy studies, most commonly utilizing diagnostic facet joint nerve blocks and an acute pain model, as Bogduk has proposed. Subsequently, Manchikanti has focused on the importance of the chronic pain model and longer lasting relief with diagnostic blocks.

To assess diagnostic accuracy of cervical facet joint nerve blocks with controlled comparative local anesthetic blocks, with updated assessment of prevalence, false-positive rate, and a description of philosophical paradigm shift from acute to chronic pain model, with concordant pain relief.

This diagnostic accuracy study was performed with retrospective assessment of data to assess prevalence and false-positive rates.

The study was performed in a non-university-based, multidisciplinary, interventional pain management, private practaverage duration of pain relief of >= 80% was 12 days with a total relief of >= 50% lasting for 55 days.

Based on this investigation, utilizing a chronic pain model, there was significant difference in the relief patterns. link2 This assessment showed prevalence and false-positive rates of 49.3% and 25.6% in chronic neck pain. Duration of relief >= 80% pain relief was 6 days with lidocaine and 12 days with bupivacaine, with total relief of >= 50% of 31 days with 55 days respectively.
= 50% of 31 days with 55 days respectively.
With the increase in the elderly population, the elderly proportion needing emergency surgery is also increasing. Despite medical advances in surgery and anesthesia, negative postoperative outcomes and high mortality rates are still present in elderly patients undergoing emergency surgery. Comorbidities are described as the main determining factors in poor outcomes. In this metaanalysis, it was aimed to investigate the effect of comorbidity on mortality in elderly patients undergoing emergency abdominal surgery.

The studies published between 2010-2019 were scanned from databases of Google Scholar, Cinahl, Pub Med, Medline and Web of Science. Quality criteria proposed by Polit and Beck were used in the evaluation of the included studies. Interrater agreement was calculated by using the Kappa statistic, effect size by using the odds ratio, and heterogeneity among studies by using the Cochran’s Q statistics. link3 Kendall’s Tau-b coefficient and funnel plot were used to determine publication bias.

A total of 9 srature, and in order to reach more precise results, studies involving wider groups of patients and further studies examining the specific effect of certain comorbid conditions are needed.
We aimed to identified clinical settings of renal transplant patients with COVID-19 Material and methods In this retrospective study, we included kidney transplant inpatients with laboratory confirmed COVID-19 who had been discharged or had died by October 1, 2020. Characteristics of the patients, basal and last outpatient biochemical parameters of the patients were recorded. Discontinuation or dosage reduction of immunosuppressives and other treatment information were documented.

20 patients were included in this study, of whom 18 were discharged and 2 died in hospital. The mean duration of hospitalization and follow-up were 9.7 ± 6.4 day and 4.5 ± 2.0 months, respectively.14 (70%) were male, mean age was 48.0±10.3 years. At admission, all had immunosuppression withdrawn and were started on methylprednisolone 16 mg/day (50%) or dexamethasone (50%). Tacrolimus/m-TOR inhibitors were reduced by 50% and all antimetabolites were discontinued. Hemodialysis was needed for 10% of patients. Acute kidney injury was detected in 25% of the patients. With respect to hospitalization time and complications, there was no significant difference between dexamethasone users and those who did not (p>0.05).The discontinued immunosupressives were resumed within 2-4 weeks after discharge according to severity of disease. No re-hospitalization or acute rejection was detected during the follow-up of the patients.

Renal transplant patients are considered a high risk group for COVID-19. It can be said that discontinuation or reduction dosages of immunosuppressives may be an effective and safe in kidney transplant patients.
Renal transplant patients are considered a high risk group for COVID-19. It can be said that discontinuation or reduction dosages of immunosuppressives may be an effective and safe in kidney transplant patients.
Dipeptidyl peptidase-4 (DPP4) inhibitors, a class of oral antidiabetic drugs, have been shown to be protective on the vascular system because of their antiinflammatory, antiatherosclerotic and vasodilatory effects. ß2-adrenoceptors (ß2-ARs) mediate the vasorelaxation in the aorta. However, ß3-adrenoceptor-mediated relaxation has not been studied in diabetic aorta yet. Thus, we aimed to study the effect of sitagliptin treatment on ß2- and ß3-adrenoceptor-mediated relaxations in the diabetic rat aorta.

8-week old Sprague Dawley rats were divided into three groups; control, diabetic, sitagliptin treated diabetic. Diabetes was induced by injection of streptozotocin (35 or 40 mg/kg, intraperitoneally). After 10 weeks of diabetes, some of the diabetic rats were treated with sitagliptin (orally, 10mg/kg/day). ß2- and ß3-AR-mediated relaxation responses were evaluated by using isoprenaline and CL316,243, respectively. ß3-AR-mediated relaxation experiments were repeated in presence of L-NAME. Western blotting and ded to clarify the relationship between the eNOS pathway and DPP-4 inhibition.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Turkey on March 10, 2020 and the number of the patients are increasing day by day. Coronavirus disease 2019 (Covid-19) has high mortality rates in the intensive care unit (ICU). We aimed to describe the demographic characteristics, co-morbidities, treatment protocols and clinical outcomes among the critically ill patients admitted to ICU of our hospital.

This cohort study included 103 consecutive patients who was laboratory confirmed Covid-19 and admitted to ICU of XXXXX Hospital between March 19 and April 13, 2020. The final date of the follow-up was April 18.

The mean age of the patients was 69.6±14.1 years. Most of the patients had increased CRP (99%), serum ferritin (73.8%), D-dimer (82.5%) and hs-troponin levels (38.8%). 34 patients (33%) had lymphocytopenia, 24 patients (23.3%) had thrombocytopenia. 63 patients (61.2%) developed ARDS, 31 patients (30.1%) had acute kidney injury and 52 patients (50.5%) had MODS during follow-up.