The aim of this study is to assess the climate effects on fisheries from a bottom-up approach based on fishers' fishing experience, knowledge, and perceptions. To perform this task, a social vulnerability assessment was conducted in two different fishing areas one in Spain and the other one in Turkey. The vulnerability was measured using the collected data and information through a structured questionnaire, and surveys were carried out among fishers in the Castelló (Spain) and the Aegean Sea (Turkey) between 2018 and 2019. Overall, the results indicated that the two studied regions have a moderate to high vulnerability and that the Aegean Sea was slightly more vulnerable than Castelló. It was also found that storms and temperature are the main climatic stressors that affect the fishing sector, and the economic indicators such as revenue from fishing in both regions showed high degrees of sensitivity. To reduce the vulnerability to climate change, adaptive measures should be implemented while taking into consideration the specific socio-economic and institutional characteristics of each region. In conclusion, the effects of climate change on the fishing sector and their social vulnerability are diverse. Consequently, there is no single climate measure that can minimize the vulnerability of fishing sectors in different regions.Bacteriocins are ribosomally-synthesized antimicrobial peptides, showing great potential as novel treatment options for multidrug-resistant pathogens. In this study, we designed a novel hybrid bacteriocin, Hybrid 1 (H1), by combing the N-terminal part and the C-terminal part of the related bacteriocins enterocin K1 (K1) and enterocin EJ97 (EJ97), respectively. Like the parental bacteriocins, H1 used the membrane-bound protease RseP as receptor, however, it differed from the others in the inhibition spectrum. Most notably, H1 showed a superior antimicrobial effect towards Staphylococcus haemolyticus-an important nosocomial pathogen. To avoid strain-dependency, we further evaluated H1 against 27 clinical and commensal S. haemolyticus strains, with H1 indeed showing high activity towards all strains. To curtail the rise of resistant mutants and further explore the potential of H1 as a therapeutic agent, we designed a bacteriocin-based formulation where H1 was used in combination with the broad-spectrum bacteriocins micrococcin P1 and garvicin KS. Unlike the individual bacteriocins, the three-component combination was highly effective against planktonic cells and completely eradicated biofilm-associated S. haemolyticus cells in vitro. Most importantly, the formulation efficiently prevented development of resistant mutants as well. These findings indicate the potential of a bacteriocins-based formulation as a treatment option for S. haemolyticus.Irritable bowel syndrome (IBS) is the most common gastrointestinal disorder significantly decreasing patients' lives of quality and placing huge economic burden on our society. Existing studies indicated that the therapeutic effects maintained for a period of time after the treatments were discontinued. It is clinically important to assess these post-treatment therapeutic effects (PTTE), which prevent IBS from relapsing. To assess the PTTE in pinaverium treatment and obtain high-quality evidence to justify the use of PTTE for long-term IBS management, we performed this controlled, double blind study on patients with IBS who were randomized to pinaverium 50 mg (n = 132) or placebo (n = 132), three times daily, for 4 weeks, and were followed up for 57 weeks after the treatments. The primary endpoints were abdominal pain and stool consistency. The secondary endpoints were pain frequency and stool frequency. The tertiary endpoints were global overall symptom and adverse events. Three days after pinaverium was discontinued, endpoints rebounded only 23.2-42.8% (P 0.05)], during which an average of 51.5-56.4% of patients (pool pinaverium and placebo data together) had IBS symptoms. These results provide clinical insights into efficient and cost-effective management of refractory IBS, and lend support to the IBS management that the selection of a therapy should consider both its effectiveness during treatment and its PTTE after the treatment.Trial registration number NCT02330029 (16/08/2016).The responsiveness of patients with chronic kidney disease (CKD) to nephrologists' care is unpredictable. We defined the longitudinal stages (LSs) 1-5 of estimated glomerular filtration rate (eGFR) by group-based trajectory modeling for repeated eGFR measurements of 7135 patients with CKD aged 20-90 years from a 13-year pre-end-stage renal disease (ESRD) care registry. Patients were considered nonresponsive to the pre-dialysis care if they had a more advanced eGFR LS compared with the baseline. Conversely, those with improved or stable eGFR LS were considered responsive. The proportion of patients with CKD stage progression increased with the increase in the baseline CKD stage (stages 1-2 29.2%; stage 4 45.8%). The adjusted times to ESRD and all-cause mortality in patients with eGFR LS-5 were 92% (95% confidence interval [CI] 86-96%) and 57% (95% CI 48-65%) shorter, respectively, than in patients with eGFR LS-3A. Among patients with baseline CKD stages 3 and 4, the adjusted times to ESRD and all-cause death in the nonresponsive patients were 39% (95% CI 33-44%) and 20% (95% CI 14-26%) shorter, respectively, than in the responsive patients. Our proposed Renal Care Responsiveness Prediction (RCRP) model performed significantly better than the conventional Kidney Failure Risk Equation in discrimination, calibration, and net benefit according to decision curve analysis. Non-responsiveness to nephrologists' care is associated with rapid progression to ESRD and all-cause mortality. The RCRP model improves early identification of responsiveness based on variables collected during enrollment in a pre-ESRD program. Urgent attention should be given to characterize the underlying heterogeneous responsiveness to pre-dialysis care.This research was set out to explore the development of arrowroot starch (AS) films using glycerol (G) as plasticizer at the ratio of 15, 30, and 45% (w/w, starch basis) using solution casting technique. The developed films were analyzed in terms of physical, structural, mechanical, thermal, environmental, and barrier properties. The incorporation of glycerol to AS film-making solution reduced the brittleness and fragility of films. An increment in glycerol concentration caused an increment in film thickness, moisture content, and solubility in water, whereas density and water absorption were reduced. The tensile strength and modulus of G-plasticized AS films were reduced significantly from 9.34 to 1.95 MPa and 620.79 to 36.08 MPa, respectively, while elongation at break was enhanced from 2.41 to 57.33%. FTIR analysis revealed that intermolecular hydrogen bonding occurred between glycerol and AS in plasticized films compared to control films. The G-plasticized films showed higher thermal stability than control films. The cross-sectional micrographs revealed that the films containing 45% glycerol concentration had higher homogeneity than 15% and 30%. Water vapour permeability of plasticized films increased by an increase in glycerol concentrations. The findings of this research provide insights into the development of bio-degradable food packaging.Visual perceptual learning (VPL) is typically specific to the trained location and feature. However, the degree of specificity depends upon particular training protocols. Manipulating covert spatial attention during training facilitates learning transfer to other locations. Here we investigated whether feature-based attention (FBA), which enhances the representation of particular features throughout the visual field, facilitates VPL transfer, and how long such an effect would last. https://www.selleckchem.com/products/gsk-j1.html To do so, we implemented a novel task in which observers discriminated a stimulus orientation relative to two reference angles presented simultaneously before each block. We found that training with FBA enabled remarkable location transfer, reminiscent of its global effect across the visual field, but preserved orientation specificity in VPL. Critically, both the perceptual improvement and location transfer persisted after 1 year. Our results reveal robust, long-lasting benefits induced by FBA in VPL, and have translational implications for improving generalization of training protocols in visual rehabilitation.Data encoded in molecules offers opportunities for secret messaging and extreme information density. Here, we explore how the same chemical and physical dimensions used to encode molecular information can expose molecular messages to detection and manipulation. To address these vulnerabilities, we write data using an object's pre-existing surface chemistry in ways that are indistinguishable from the original substrate. While it is simple to embed chemical information onto common objects (covers) using routine steganographic permutation, chemically embedded covers are found to be resistant to detection by sophisticated analytical tools. Using Turbo codes for efficient digital error correction, we demonstrate recovery of secret keys hidden in the pre-existing chemistry of American one dollar bills. These demonstrations highlight ways to improve security in other molecular domains, and show how the chemical fingerprints of common objects can be harnessed for data storage and communication.The production of activated carbon from eucalyptus wood chips by steam activation in a 2000 kg batch intermittent rotary kiln with continuous carbonization-steam activation process conducted at 500 °C to 700 °C was studied. The activated carbon products were characterized by FTIR, SEM-EDS, Raman spectroscopy, and BET analysis. Percent yields, iodine number, and methylene blue number of the produced activated carbon materials were measured as well. It was shown that the percent yields of the activated carbon materials made in the temperature range from 500 to 700 °C are 21.63 ± 1.52%-31.79 ± 0.70% with capacities of 518-737 mg I2/g and 70.11-96.93 mg methylene blue/g. The BET surface area and micropore volume of the activated carbons are 426.8125-870.4732 m2/g and 0.102390-0.215473 cm3/g, respectively. The steam used in the process could create various oxygen containing surface functional groups such as -CO and -COC groups. In addition, it could also increase the amorphous nature of the activated carbon product. These properties of the activated carbon products are increased with increasing steam activation temperature from 500 to 700 °C. As a result, the activated carbon materials produced at activation temperatures of 600 °C and 700 °C exhibit higher adsorption.Fano resonances of bilayer graphene could be attractive for thermoelectric devices. The special profile presented by such resonances could significantly enhance the thermoelectric properties. In this work, we study the thermoelectric properties of bilayer graphene single and double barrier structures. The barrier structures are typically supported by a substrate and encapsulated by protecting layers, reducing considerably the phonon thermal transport. So, we will focus on the electronic contribution to the thermal transport. The charge carriers are described as massive chiral particles through an effective Dirac-like Hamiltonian. The Hybrid matrix method and the Landauer-Büttiker formalism are implemented to obtain the transmission, transport and thermoelectric properties. The temperature dependence of the Seebeck coefficient, the power factor, the figure of merit and the efficiency is analyzed for gapless single and double barriers. We find that the charge neutrality point and the system resonances shape the thermoelectric response.