In addition, biosynthesized AgCl-NPs were established to have remarkable antioxidant activity. https://www.selleckchem.com/products/scutellarin.html All this pointed out that the proposed new biosynthesis approach resulted in production of AgCl-NPs with convenient biomedical applications.Current food traceability systems have a number of problems, such as data being easily tampered with and a lack of effective methods to intuitively analyze the causes of risks. Therefore, a novel method has been proposed that combines blockchain technology with visualization technology, which uses Hyperledger to build an information storage platform. Features such as distribution and tamper-resistance can guarantee the authenticity and validity of data. A data structure model is designed to implement the data storage of the blockchain. The food safety risks of unqualified detection data can be quantitatively analyzed, and a food safety risk assessment model is established according to failure rate and qualification deviation. Risk analysis used visual techniques, such as heat maps, to show the areas where unqualified products appeared, with a migration map and a force-directed graph used to trace these products. Moreover, the food sampling data were used as the experimental data set to test the validity of the method. Instead of difficult-to-understand and highly specialized food data sets, such as elements in food, food sampling data for the entire year of 2016 was used to analyze the risks of food incidents. A case study using aquatic products as an example was explored, where the results showed the risks intuitively. Furthermore, by analyzing the reasons and traceability processes effectively, it can be proven that the proposed method provides a basis to formulate a regulatory strategy for regions with risks.The gut microbiota may have an impact on obesity. To date, the majority of studies in obese patients reported microbiota composition in stool samples. The aim of this study was to investigate the duodenal mucosa dysbiosis in adult obese individuals from Campania, a region in Italy with a very high percentage of obese people, to highlight microbial taxa likely associated with obesity. Duodenum biopsies were taken during upper gastrointestinal endoscopy in 19 obese (OB) and 16 lean control subjects (CO) and microbiome studied by 16S rRNA gene sequencing. Duodenal microbiome in our groups consisted of six phyla Proteobacteria, Firmicutes, Actinobacteria, Fusobacteria, Bacteroidetes and Acidobacteria. Proteobacteria (51.1% vs. 40.1%) and Firmicutes (33.6% vs. 44.9%) were significantly (p less then 0.05) more and less abundant in OB compared with CO, respectively. Oribacterium asaccharolyticum, Atopobium parvulum and Fusobacterium nucleatum were reduced (p less then 0.01) and Pseudomonadales were increased (p less then 0.05) in OB compared with CO. Receiver operating characteristic curve analysis showed Atopobium and Oribacterium genera able to discriminate with accuracy (power = 75% and 78%, respectively) OB from CO. In conclusion, increased Proteobacteria and decreased Firmicutes (Lachnospiraceae) characterized the duodenal microbiome of obese subjects. These data direct to further studies to evaluate the functional role of the dysbiotic-obese-associated signature.This study aimed to develop nanodelivery systems for enhancing the Ocimum sanctum Linn. extract delivery into the skin. Rosmarinic acid (RA) was used as a marker for the quantitative determination of the extract by high-performance liquid chromatography. Nanostructured lipid carriers (NLC), nanoemulsion, liposome, and niosome, were developed and characterized for internal droplet size, polydispersity index (PDI), and zeta potential using photon correlation spectroscopy. Irritation properties of each formulations were investigated by hen's egg test on the chorioallantoic membrane. In vitro release, skin permeation, and skin retention are determined. NLC was suggested as the most suitable system since it enhances the dermal delivery of RA with the significant skin retention amount of 27.1 ± 1.8% (p less then 0.05). Its internal droplet size, PDI, and zeta potential were 261.0 ± 5.3 nm, 0.216 ± 0.042, and -45.4 ± 2.4 mV, respectively. RA released from NLC with a sustained release pattern with the release amount of 1.29 ± 0.15% after 24 h. NLC induced no irritation and did not permeate through the skin. Therefore, NLC containing O. sanctum extract was an attractive dermal delivery system that was safe and enhanced dermal delivery of RA. It was suggested for further used as topical anti-ageing products.Nowadays, tuberculosis, scarlet fever, measles, influenza, and mumps are five major notifiable respiratory infectious diseases (RIDs) in China. The objective of this study was to describe, visualize, and compare the spatial-temporal distributions of these five RIDs from 2006 to 2016. In addition to descriptive epidemiology analysis, seasonality and spatial autocorrelation analysis were also applied to explore the epidemiologic trends and spatial changing patterns of the five RIDs, respectively. The results indicated that the incidence of tuberculosis, measles, and mumps presented a downtrend trend, while those of scarlet fever and influenza was in a strong uptrend across the research period. The incidences of the five diseases all peaked in spring. There were significant spatial disparities in the distribution of tuberculosis, scarlet fever, and measles cases, with the hotspots mainly located in the western plateau region, northern plain region, and southern mountainous region. To conclude, notable epidemiological differences were observed across regions, indicating that some provincial units should pay more attention to prevent and control respiratory infectious diseases.Leachate collection system (LCS) clogging is a common operational problem in municipal solid waste (MSW) landfills in China, which can result in high leachate levels that threaten the safety of landfill operations and subsequently increase the leachate leakage risk. In our previous research, a filtration test was conducted and the physical clogging effect was evaluated. To fully analyze the LCS failure, in this study, a set of column experiments were carried out to investigate the biochemical clogging development and mechanisms. Results showed that the biofilm and deposited CaCO3 composed the primary clogging materials. During the experimental period, the hydraulic conductivities in simulated gravel and nonwoven geotextile drainage layers were observed (91.7% and five orders of magnitude reduction), and decreased to 10-4 and 10-8 m s-1, respectively. Therefore, the significance of the geotextile layer in LCS designing needs to be reconsidered. The biochemical clogging was positively correlated with volatile fatty acids (VFAs), and Ca2+ loading and the Ca2+ played the dominant role.