The aim To identify clinical and laboratory signs of digestive system disease in HIV-infected patients for helping family physicians.

Materials and methods Research was conducted at five regional HIV / AIDS centers in Ukraine during 2017-2019. Randomly selected 342 adult HIV-infected patients were divided into two groups, with concomitant digestive system diseases and without concomitant digestive system disease. Statistical analysis was performed using the software package EZR 1.41 (Saitama Medical Center, Jichi Medical University, Japan).

Results The incidence of digestive system disease in patients with HIV clinical stages II, III and IV was significantly higher than in patients with HIV clinical stage I. Gastrointestinal disease was also significantly associated with the incidence of tuberculosis, candidiasis, kidney disease and HIV encephalopathy. Incidence of asthenic-vegetative and dyspeptic syndromes, weight loss, anemia and leukopenia, elevated liver enzymes, low CD4 counts and detectable viralesponse to antiretroviral therapy.
Introduction Lifestyle modification, including changing eating habits, plays an essential role in the prevention of stroke. The aim The study aimed to assess the nutritional prevention of cerebrovascular diseases in adult inhabitants of Poland.

Material and Methods The study was conducted using the author's questionnaire among 145 women and 76 men, aged 18 - 30 (53.9%) and 50 - 70 (46.1%) years.

Results The following stroke risk factors were found in the examined group overweight or obesity (46.6%), lack of regular physical activity (48%), smoking (33%), hypertension (22.1%), dyslipidemia (8.6%), diabetes (5.9%), and cardiac arrhythmias (6.3%). The younger subjects compared to older ones more often declared the daily consumption of whole-grain cereal products and vegetables, fish at least once a week, and they preferred vegetable oils. On the other hand, older subjects declared the consumption of sweets, sweet drinks, salt, and fast food less frequently than younger ones. Also, fruits were more often chcular diseases is still necessary and should be age-appropriate.
The aim To determine a possible role of nitric oxide system as one of the pathogenesis links in Stevens-Johnson syndrome depending on the severity of disease progression.

Material and methods We examined 11 patients with Stevens-Johnson syndrome. The function of nitric oxide system (NO - NOS) in blood serum was examined.

Results During the study of nitric oxide system (NO-NOS) in patients with SJS, it was observed that NO2¯ level was increased by 1.53 times, NO3¯ level - by 3.33 times, activity of total NOS - by 5.78 times, constitutive (cNOS) - by 1.81 times and inducible (iNOS) - by 13.36 times.

Conclusions The intensity of nitric oxide system function was studied in patients with Stevens-Johnson syndrome and dependence of changes of its parameters from the clinical signs of disease was detected. It was found that the determination of nitrite and nitrate anion levels in blood serum can be used for the purpose of predicting the disease course and choosing the therapy methods for the patients with SJS.
Conclusions The intensity of nitric oxide system function was studied in patients with Stevens-Johnson syndrome and dependence of changes of its parameters from the clinical signs of disease was detected. It was found that the determination of nitrite and nitrate anion levels in blood serum can be used for the purpose of predicting the disease course and choosing the therapy methods for the patients with SJS.
The aim To determine the morphometric parameters of the parenchymal and stromal liver components of healthy newborns.

Material and methods The morphometric investigation included 45 liver tissue biopsies of healthy newborns. All morphometric parameters of the parenchymal and stromal liver components were calculated using the Avtandilov microscopic morphometric grid. It was inserted into the microscope ocular tube with a total × 200 microscope magnification. The number of points that were found on the corresponding types of parenchymal and stromal liver components was calculated. In every case, it was selected 10 random microscopic areas and then all data were obtained, calculated and presented as percentages.

Results Morphometric parameters of hepatocytes mononuclear hepatocytes - 93.5±7.1 %, two-nuclear hepatocytes - 6.5±1.2 %, BMHC (bi-/mononuclear hepatocytes coefficient) - 0.06±0.01, hepatocytes with fat vacuoles - 0.5±0.2 %. Parenchymal and stromal liver components parenchyma - 74.2±4.3 %, stroma (including blood vessels and bile ducts) - 25.8±2.6 %, SPI (stroma/parenchyma index) - 0.34±0.01. Morphometric parameters of all of the liver components hepatocytes - 74.2±4.3 %, portal tracts - 3.1±0.6 %, central veins - 9.3±1.4 %, sinusoids - 10.5±1.3 %, bile ducts - 2.9±0.2 %. Expression level parameters fibronectin - 17.3±2.5 %, collagen type I - 9.7±1.9 %, collagen type III - 10.1±0.9 %, collagen type IV - 5.9±0.2 %. https://www.selleckchem.com/ Parameters of liver fibrosis biomarkers APRI (index) - 0.19±0.01, а FIB-4 (index) - 0.022±0.001.

Conclusions The morphometric parameters of the parenchymal and stromal liver components of healthy newborns can be used as a control group in the study of any pathological conditions of the liver of newborns.
Conclusions The morphometric parameters of the parenchymal and stromal liver components of healthy newborns can be used as a control group in the study of any pathological conditions of the liver of newborns.The mycobacterial cell envelope has a diderm structure, composed of an outer mycomembrane, an arabinogalactan-peptidoglycan cell wall, a periplasm, and an inner membrane. Lipomannan (LM) and lipoarabinomannan (LAM) are structural and immunomodulatory components of this cell envelope. LM/LAM biosynthesis involves a number of mannosyltransferases and acyltransferases, and MptA is an α1,6-mannosyltransferase involved in the final extension of the mannan chain. Recently, we reported the periplasmic protein LmeA being involved in the maturation of the mannan backbone in Mycobacterium smegmatis Here, we examined the role of LmeA under stress conditions. We found that lmeA transcription was upregulated under two stress conditions stationary growth phase and nutrient starvation. Under both conditions, LAM was decreased, but LM was relatively stable, suggesting that maintaining the cellular level of LM under stress is important. Surprisingly, the protein levels of MptA were decreased in an lmeA deletion (ΔlmeA) mutant under both stress conditions.