Cardiorenal syndrome (CRS) is a condition that defines disorders of the heart and kidneys whereby "acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other". Early diagnosis of its biomarkers has a significant impact on the treatment and prognosis of the CRS. Elevated serum NGAL and NT-proBNP levels are independent risk factors for predicting heart and kidney disease. Therefore, we proposed early detection of type 1 CRS using serum NGAL in combination with NT-proBNP.

This study intended to investigate the clinical value of serum NGAL in combination with NT-proBNP in the early diagnosis of type 1 CRS.

In this paper, 80 patients with type 1 CRS and 80 healthy controls admitted to our hospital from January 2019 to August 2020 were retrospectively included, and the predictive value of single index and combined indices for predicting CRS were judged by calculating the correlation between serum NGAL, NT-proBNP and the creatinine levels and plotting receiver operating characteristic (ROC) curves.

There was no difference in baseline data between the control and patient groups. Serum NGAL and NT-proBNP in the patient group were significantly higher than those in the control group, and were positively correlated with changes in blood creatinine. The ROC curves showed that serum NGAL and NT-proBNP independently had a high predictive value for CRS, and the combination of the two had a better predictive value.

Serum NGAL in combination with NT-proBNP is of high clinical value for the early diagnosis of type 1 CRS.
Serum NGAL in combination with NT-proBNP is of high clinical value for the early diagnosis of type 1 CRS.
To investigate the individual level of radiation exposure in hospital workers from 2010 to 2018.

Oral radiology workers in our hospital including medical imaging technicians and radiation therapists from 2010 to 2018 were selected as the subjects of investigation. The oral radiological workers were monitored quarterly according to the level of external exposure via individual dose monitoring standards. The monitoring data were aggregated, analyzed and evaluated.

A total of 531 hospital radiology workers were monitored from 2010 to 2018. The rate of effective monitoring per year for medical imaging technicians and radiation therapists was 97.35% and 97.47%, respectively. The average collective effective dose was 8.511 mSv, and annual effective dose per capita was 0.148 mSv. The highest collective effective dose was in 2017, while the highest annual effective dose per capita was in 2010. The annual effective dose per capita for medical imaging technicians was lower than that for radiation therapists. https://www.selleckchem.com/products/i-bet-762.html The abnormal rate of personal doses of radiation therapists was higher than that for medical imaging technicians. The collective effective dose changes in the two types of radiation workers were monitored from 2010 to 2018, showing an increased trend. The fluctuations of annual effective dosing per capita monitored from 2010 to 2018 in radiation therapists was more significant than that in medical imaging technicians.

Oral radiation workers monitored were all far below the dose limit of 20 mSv, which indicated that the working environment of oral radiation workers in our hospital was safe with good radiation condition and protection.
Oral radiation workers monitored were all far below the dose limit of 20 mSv, which indicated that the working environment of oral radiation workers in our hospital was safe with good radiation condition and protection.
This study aimed to explore the correlation between serum vitamin D and inflammatory factors in mice with allergic rhinitis.

Female BALB/c mice in SPF grade were used to construct allergic rhinitis model by systemic injection and repeated nasal antigens. 12 allergic rhinitis mice without other treatment were treated as group A, another 12 allergic rhinitis mice treated with vitamin D
were selected as group B, and group C included 12 mice that received PBS injection. Nasal symptoms, behavioral scores, serum vitamin D levels, nasal mucosal pathology HE staining, serum inflammatory factors IL-4 and IFN-γ levels were compared between the groups. The relationship between serum vitamin D level and serum inflammatory factor levels were analyzed.

The nasal itching, sneezing, nasal secretions, behavioral scores, and total scores of group A and group B were significantly different from those of group C (P < 0.05). It showed obvious nasal mucosal edema, interrupted and lodging cilia, increased goblet cells carrying secretory bodies, and the inflammatory cells infiltrated under the mucosa in group A. They were significantly reduced in group B compared with group A. Total vitamin D levels and vitamin D
levels exhibited obviously difference among the groups (F = 53.19, P < 0.05). IL-4 and INF-γ levels in group A and group B were markedly higher than those in group C (P < 0.05). IL-4 decreased following serum vitamin D level elevation (Y = -3.3515X+122.04, R
= 0.9984).

Vitamin D in young mouse is implicated with allergic rhinitis and attenuated inflammation. Vitamin D level was significantly negatively correlated with IL-4, suggesting that vitamin D was closely related to inflammation.
Vitamin D in young mouse is implicated with allergic rhinitis and attenuated inflammation. Vitamin D level was significantly negatively correlated with IL-4, suggesting that vitamin D was closely related to inflammation.
Analysis of the effect of Ginkgo biloba Damo injection combined with troxerutin on patients with acute cerebral infarction (ACI) by regulating the TLR4/NF-κB signaling pathway.

150 patients with ACI were recruited for a prospective study. These patients were randomly divided into Ginkgo biloba Damo treatment group (n=75) and combined treatment group (Ginkgo biloba Damo + troxerutin, n=75) bilobabiloba. The patients in both groups were treated with conventional treatment. In addition, patients in the Ginkgo biloba Damo treatment group were treated with Ginkgo biloba Damo injection, and those in the combined treatment group were treated with Ginkgo biloba Damo injection combined with troxerutin. The National Institutes of Health Stroke Scale (NIHSS) and Barthel Index (BI) of the two groups were compared. The serum levels of GSH-Px, OX-LDL, CAT, TLR4, NF-κB p65, TNF-α, IL-1β and IL-6 were detected. The therapeutic effects of the two groups were compared.

After treatment, compared with the Ginkgo biloba Damo group, the combined treatment group had a lower NIHSS score and lower expression levels of OX-LDL, TLR4, NF-κB p65, TNF-α, IL-1β, and IL-6, but higher Barthel score and total effective rate as well as higher serum levels of GSH-Px and CAT (all P<0.