The ternary bismuthate nanoscale materials exhibit great application promising in the fields of photocatalysts, sensors and batteries et al. Conclusion Large-scale synthesis of ternary bismuthate nanoscale materials at low cost, doping and combination using different nanoscale materials are important research directions for future research.
The ternary bismuthate nanoscale materials including zinc bismuthate, copper bismuthate, barium bismuthate, silver bismuthate, sodium bismuthate, lanthanum bismuthate nanoscale materials can be synthesized by hydrothermal route, sol-gel route, solvothermal decomposition route and ion-exchange method et al. The ternary bismuthate nanoscale materials exhibit great application promising in the fields of photocatalysts, sensors and batteries et al. https://www.selleckchem.com/products/cd437.html Conclusion Large-scale synthesis of ternary bismuthate nanoscale materials at low cost, doping and combination using different nanoscale materials are important research directions for future research.
We aim to investigate the interaction of curcumin with p53-fibrinolytic system, smad dependent and independent pathways underlying their prime role during lung injury and fibrosis.

Curcumin an active component of Curcuma longa plant substantially modulates respiratory conditions. TGFβ1 plays a central role in lung remodeling by balancing extracellular matrix (ECM) production and degradation which is a hallmark for alveolar EMT. However, it is not known yet the crosstalk of curcumin with TGF- β1 mediated p53- Fibrinolytic system regulating alveolar EMT leading to IPF. In the present study, the potential molecular mechanism of curcumin in TGF-β1 mediated p53-fibrinolytic system in basal alveolar epithelial cells was explored.

To understand the potential molecular mechanism of curcumin in TGF-β1 mediated p53-fibrinolytic system in basal alveolar epithelial cells.

Basal alveolar epithelial cells were treated with TGF- β1 to induce alveolar EMT and after 24 hrs curcumin were administered to study its anti-fibrotic effects. Molecular techniques like immuno blot, RT-PCR and immunofluorescence were performed to assess the anti-fibrotic role of curcumin on EMT markers, IL-17A, p53-smad interaction to investigate the anti-fibrotic role of curcumin.

The results indicated that TGF-β1-induced EMT in A549 cells exhibited altered expression of the IL-17A, p53- fibrinolytic markers and EMT markers at the mRNA and protein level. Intervention with curcumin attenuated alveolar EMT and inactivated TGF-β1 induced Smad/non Smad signaling pathways via blocking p53-fibrinolytic system.

This study provides the first evidence of the dynamic response of curcumin on TGF-β1 mediated p53- fibrinolytic system during alveolar injury in vitro.
This study provides the first evidence of the dynamic response of curcumin on TGF-β1 mediated p53- fibrinolytic system during alveolar injury in vitro.
Adult growth hormone deficiency (GHD) is considered a rare condition. Current guidelines state that GH provocative test is indicated in patients affected by organic hypothalamic/pituitary disease or with history of head injury, irradiation, hemorrhage or hypothalamic disease with multiple pituitary deficiencies. Nevertheless, clinical picture related to GHD may be subtle.

We have retrospectively evaluated the indication to GHRH+arginine test in our monocentric cohort of patients treated with hrGH in order to assess whether other conditions had been considered as a rationale for provocative testing.

96 patients (51 females and 45 males), aged 19-67 years were included. The GHRH+arginine test had been performed in 29 patients with organic hypothalamic/pituitary disease and in 4 patients for Childhood onset-GHD (Co-GHD). In other patients the diagnosis was suspected for "non classical" reasons in clinical picture suspected for GHD.

Classical indications included previously known primary empty sella (n=15ld be to identify subsets of patients with clinical conditions caused or worsened by underlying unrecognized GHD.
The aim of the study was to assess the antihyperglycemic activity of Brassica oleracea.

Collard green or Brassica oleracea var. viridis which belongs to Brassicaceae family is ranked at 10th place of "powerhouse" vegetables, and it is commonly used traditionally for the treatment of diabetes in Morocco.

This current investigation aimed to assess the antihyperglycemic capacity of the aqueous extract of Collard green leaves.

The effect of a single (6 hours) and repeated (seven days of treatment) oral administration of Collard green aqueous extract (CGAE) at a dose of 60 mg/kg on glucose and lipid profile was examined in normal and streptozotocin-induced diabetic rats. Additionally, histopathological examination of liver was carried out according to the Hematoxylin-Eosin method. Furthermore, a preliminary phytochemical screening, and the quantification of phenolic, flavonoid and tannins contents as well as the antioxidant activity using DPPH assay were carried out.

The results demonstrated that Collard green A.E. (CGAE) exhibited a significant antihyperglycemic effect and positive improvement liver histology in diabetic rats. After a single oral administration of CGAE, blood glucose levels were lowered from 15±2 mM to 4.9±1 mM (p<0.0001) at the sixth hour in diabetic rats but no change was observed in normal rats. Repeated CGAE administration was able to reduce blood glucose levels from 15±2 mM to normal values (5±1 mM at the seventh day, p<0.0001) while the extract had no effect in normal rats. In addition, we revealed that CGAE is rich in several phytochemical compounds and exerts an important antioxidant activity.

In conclusion, this study demonstrates that Collard green possesses a beneficial effect against diabetes, and can be used in the program diet of diabetic patients.
In conclusion, this study demonstrates that Collard green possesses a beneficial effect against diabetes, and can be used in the program diet of diabetic patients.The food industry is constantly shifting focus based on prebiotics as health-promoting substrates rather than just food supplements. A prebiotic is "a selectively fermented ingredient that allows specific changes, both in the composition and/or activity in the gastrointestinal microflora that confers benefits upon host well-being and health." Prebiotics exert a plethora of health-promoting effects, which has lead to the establishment of multimillion food and pharma industries. The following are the health benefits attributed to prebiotics mineral absorption, better immune response, increased resistance to bacterial infection, improved lipid metabolism, possible protection against cancer, relief from poor digestion of lactose, and reduction in the risk of diseases such as intestinal disease, non-insulin-dependent diabetes, obesity and allergy. Numerous studies in both animals and humans have demonstrated the health benefits of prebiotics.