The present study retrospectively determined the incidence of obstructive sleep apnea (OSA) after a primary haemorrhagic event compared to an ischaemic stroke during the post-acute recovery period ( x ¯ >3 months). Consideration of medications taken during the sleep evaluation provided additional information on the association between OSA and pathophysiological conditions that may increase the risk of a repeated cardiovascular event. The medical records from 103 patients that underwent a type I fully attended overnight polysomnography as a standard evaluation procedure at a rehabilitation facility were reviewed. Diagnosis of ischaemic or primary haemorrhagic stroke was obtained from a neurological report that was typically confirmed by imaging. Medications taken at the time of the sleep study were documented. Age-adjusted assessment of sleep-disordered breathing revealed a higher incidence of apnea and hypopnea in the ischaemic stroke group (p less then 0.005). Patients with ischaemic stroke were also more likely to have severe OSA (p less then 0.005). In comparison, a higher percentage of patients with haemorrhagic stroke had an apnea-hypopnea index less then 5 events/hr (p less then 0.005). Those with an ischaemic stroke were taking more lipid lowering agents (p less then 0.05). Results suggest that apnea is less prevalent after a haemorrhagic stroke, independent of hypertension, compared to an ischaemic stroke. An increase in predictive values for OSA was observed for indicators of diabetes (p less then 0.05). https://www.selleckchem.com/products/ABT-263.html These data indicate that it is relevant to consider stroke type when determining the risk of OSA during the chronic recovery period thus facilitating new strategies for stroke recurrence prevention.Covalent organic frameworks (COFs) are a class of promising photocatalysts for conversing light energy into chemical energy. Based on the tunable building blocks, COFs can be well-designed as photocatalyst for mediating reversible addition-fragmentation chain-transfer (RAFT) polymerization. Herein, 1,3,6,8-tetrakis(4-formylphenyl)pyrene (TFPPy) and 2,2″-bipyridine-5,5″-diamine (Bpy) are chosen to construct imine-based TFPPy-Bpy-COFs for catalyzing RAFT polymerization of methacrylates under white light irradiation. The well-defined polymers with precise molecular weight and narrow molecular weight distribution are obtained. The switch on/off light experiments suggest excellent temporal control toward RAFT polymerization system and the chain-extension reaction indicates high chain-end fidelity of macro-initiators. Mechanism study clarifies that the electron transfer between excited state of TFPPy-Bpy-COFs and RAFT agent can form living radicals to mediate polymerization. This methodology provides a novel platform for reversible-deactivation radical polymerization using COFs as heterogeneous catalysts.Polyurethane (PU) has not only been widely used in the daily lives, but also extensively explored as an important class of the essential polymers for various applications. In recent years, significant efforts have been made on the development of self-healable PU materials that possess high performance, extended lifetime, great reliability, and recyclability. A promising approach is the incorporation of covalent dynamic bonds into the design of PU covalently crosslinked polymers and thermoplastic elastomers that can dissociate and reform indefinitely in response to external stimuli or autonomously. This review summarizes various strategies to synthesize self-healable, reprocessable, and recyclable PU materials integrated with dynamic (reversible) Diels-Alder cycloadduct, disulfide, diselenide, imine, boronic ester, and hindered urea bond. Furthermore, various approaches utilizing the combination of dynamic covalent chemistries with nanofiller surface chemistries are described for the fabrication of dynamic heterogeneous PU composites.Pseudomonas aeruginosa (P. aeruginosa) is a life-threatening pathogen associated with multiantibiotic resistance, which is largely caused by its strong ability to form biofilms. Recent research has revealed that gallium (III) shows an activity against the biofilm of P. aeruginosa by interfering with Fe metabolism. The antibacterial activity of the combination of Ga3+ ion and antibiotic rifampicin (RMP) against P. aeruginosa PAO1 is investigated. An anionic polymer poly2-[(2-methylprop-2-enoyl)oxy]ethylphosphonic acid (PDMPOH) is exploited to form complexes (GaPD) with Ga3+ . The GaPD complexes act as a carrier of Ga3+ and release Ga3+ via enzymatic degradation by bacterial lipases. GaPD is found to damage the outer membrane, leading to enhanced cellular uptake of RMP and Ga3+ due to increased outer membrane permeability, which inhibits the RNA polymerase and interferes with Fe metabolism. The antibiofilm activity and biocompatibility of the GaPD system offer a promising treatment option for P. aeruginosa biofilm-related infections.Covalent adaptable networks (CANs) have recently received extensive interests due to their reprocessability and repairability. Rethinking the libraries of the published CANs, most of them are fabricated by one/two-component reactions and few cases utilize multi-component reactions to construct CANs while multi-component reactions are conductive to tailoring the properties of polymers due to their structural designability and flexible choice of raw materials. A novel kind of dynamic covalent bond named aminoesterenamide is presented through three-component reaction between acetoacetyl, amine and isocyanate. Aminoesterenamide exhibits thermal reversibility through dissociating into vinylogous urethane and isocyanate. When it is used to prepare CANs, the synthesized polymer networks can be reprocessed many times via the exchange reaction between aminoesterenamides. Moreover, the forming of aminoesterenamide involving three starting components imparts CANs with great freedom to tailor their properties. Therefore, the authors believe this method that utilizes three-component reaction to fabricate CANs would bring new stories and perspectives to the exploration of new types of CANs.Adaptive radiations have proven important for understanding the mechanisms and processes underlying biological diversity. The convergence of form and function, as well as admixture and adaptive introgression, are common in adaptive radiations. However, distinguishing between these two scenarios remains a challenge for evolutionary research. The Midas cichlid species complex (Amphilophus spp.) is a prime example of adaptive radiation, with phenotypic diversification occurring at various stages of genetic differentiation. One species, A. labiatus, has large fleshy lips, is associated with rocky lake substrates, and occurs patchily within Lakes Nicaragua and Managua. By contrast, the similar, but thin-lipped, congener, A. citrinellus, is more common and widespread. We investigated the evolutionary history of the large-lipped form, specifically regarding whether the trait has evolved independently in both lakes from ancestral thin-lipped populations, or via dispersal and/or admixture events. We collected samples from distinct locations in both lakes, and assessed differences in morphology and ecology. Using RAD-seq, we genotyped thousands of SNPs to measure population structure and divergence, demographic history, and admixture. We found significant between-species differences in ecology and morphology, local intraspecific differences in body shape and trophic traits, but only limited intraspecific variation in lip shape. Despite clear ecological differences, our genomic approach uncovered pervasive admixture between the species and low genomic differentiation, with species within lakes being genetically more similar than species between lakes. Taken together, our results suggest a single origin of large-lips, followed by pervasive admixture and adaptive introgression, with morphology being driven by local ecological opportunities, despite ongoing gene-flow.Beyond a traditional stimuli-responsive soft actuator that shows a single motion by a stimulus, multidirectional actuation reversal with a single stimulus is highly required in applications such as shape morphing sensors and soft robotics. Liquid crystal elastomers (LCEs) are one of the most attractive candidates for the soft actuator due to their capability of stimuli-responsive shape changing in 3D, which is programmable with local orientation of LC mesogens. Here, a simple but effective method to fabricate monolithic LCE actuators that are capable of reversible curvature reversal in bending and twisting deformation by a single stimulus-heat-is reported. The curvature reversal of the LCE film can be programmed by means of asymmetric crosslinking density along the thickness and the orientation of the LC mesogens. The curvature reversal of the monolithic LCE film exhibits highly reversible (more than 100 times) and fast actuation (≈3-5 s) by heating and cooling, allowing new concept of a practical application using LCE material a self-regulated smart valve that is capable of qualitatively sorting liquids by temperature. It is believed that this system is potentially applied to a self-regulated sorting platform for various endothermic and exothermic chemical or biological reactions.Sustainable harnessing of natural resources is key moving toward a new-generation electronics, which features a unique combination of electronic functionality, low cost, and absence of environmental and health hazards. Within this framework, edible electronics, of which transistors and circuits are a fundamental component, is an emerging field, exploiting edible materials that can be safely ingested, and subsequently digested after performing their function. Dielectrics are a critical functional element of transistors, often constituting their major volume. Yet, to date, there are only scarce examples of electrolytic food-based materials able to provide low-voltage operation of transistors at ambient conditions. In this context, a cost-effective and edible substance, honey, is proposed to be used as an electrolytic gate viscous dielectric in electrolyte-gated organic field-effect transistors (OFETs). Both n- and p-type honey-gated OFETs (HGOFETs) are demonstrated, with distinctive features such as low voltage ( less then 1 V) operation, long-term shelf life and operation stability in air, and compatibility with large-area fabrication processes, such as inkjet printing on edible tattoo-paper. Such complementary devices enable robust honey-based integrated logic circuits, here exemplified by inverting logic gates and ring oscillators. A marked device responsivity to humidity provides promising opportunities for sensing applications, specifically, for moisture control of dried or dehydrated food.Dynamic covalent materials are a class of polymer that could be stress-relaxation, reprocessable and self-healing due to dynamic cross-links in network. Dynamic cross-links play an important role in the typical characteristic of self-healing polymers. It was meaningful to understand the effect of crosslinking degree on the properties of poly(1,2,3-triazolium) (PTAM). In this article, the dynamic covalent network of PTAM adhesive has been used to study the effect of crosslinking degree. A series of PTAM adhesive with different crosslinking degrees have been obtained by changing the amount of crosslinker. Adhesion property can first rise then fall down with the increase of crosslinking degree and the best lap-shear strength was above 20 MPa. Creep resistance and solvent resistance can be enhanced with the increase of crosslinking degree. Self-healing studies have shown that crosslinking degree can enhance the ability of self-healing, but too high crosslinking degree raises the temperature of self-healing and causes side reaction which reduces the self-healing efficiency.