The mRNA expression profiles and accompanying medical information of UCEC clients most notable study had been acquired from a publicly available database. We later classified the patients into experimental and training sets. Next, utilising the the very least absolute shrinking and selection operator (LASSO) Cox regression model, we established the multigene top features of the TCGA experimental set and verified them into the validation set.An original model of genes connected to ferroptosis gets the potential become cure option for UCEC and will be used for the prognostic prediction associated with disease.Despite a rise of interest in wrongful convictions, grant on the social procedures through which the experience of wrongful conviction harms family members life as time passes remains limited. In this article, I explore the shifting and collecting "relational expenses of wrongful beliefs," defined as the harms that men's familial interactions sustained over three points with time The moment of wrongful belief, the time scale of wrongful imprisonment, in addition to post-prison duration. Through detailed interviews with 15 exonerated males, we discover that the relational costs of wrongful convictions accrued and changed during the period of participants' wrongful conviction trips. Even though minute of wrongful conviction represented a collective upheaval that members distributed to their families, familial assistance waned in the long run (especially among men lacking socioeconomic privilege), sharpening the harms of wrongful imprisonment. Following their particular release, individuals' hostility toward loved ones and their particular sense of personal displacement impeded their ability to reconstruct the few familial ties that were still offered to all of them. These conclusions facilitate an understanding of familial interruption as a fluid personal process, rather than the product of exonerees' emotional traumas.Peptide vaccines and immunotherapies against aggregating proteins involved in the pathogenesis and development of Alzheimer's disease illness (AD) - the β-amyloid peptide (Aβ) and tau - are promising therapeutic avenues against AD. Two decades of effort has generated the controversial Food And Drug Administration approval associated with monoclonal antibody Aducanumab (Aduhelm), which has subsequentially sparked the revival and expedited report on guaranteeing monoclonal antibody immunotherapies that target Aβ. In this review, we explore the development of Aβ and tau peptide vaccines and immunotherapies with monoclonal antibodies in clinical trials against AD.Background Psychomotor delay, epilepsy and dysmorphic functions tend to be medical signs that are explained in multiple syndromes due to chromosomal imbalances or mutations concerning crucial genetics implicated in the stages of Early Embryonic Development. In this context, we report a 10 years of age Tunisian patient by using these three indications. Our objective would be to determine the reason for developmental, behavioral and facial abnormalities in this patient. Techniques We utilized banding cytogenetics (karyotype) and Array Comparative Genomic Hybridization (Array CGH) to this purpose. Outcomes The karyotype was in favor of a derivative of chromosome 7 into the patient and Array CGH evaluation unveiled a loss in genetic material in 7p22.3-p22.1 (4,56 Mb) with a gain at 8q24.23-q24 (9.20 Mb) caused by maternal 7/8 reciprocal translocation. An in silico analysis associated with the unbalanced area was carried out and showed that the 7p22.3-p22.1 deletion contains eight genes. Included in this, BRAT1 gene, previously described in a number of neurodevelopmental conditions, may be an applicant gene which absence could be correlated to your patient's phenotype. However, the 8q24.23-q24 replication might be mixed up in phenotype of the client. Conclusion In this research, we report the very first time a 7p deletion/8q duplication in a patient with psychomoteur wait, epilepsy and facial dysmorphism. Our research showed that range CGH however helpful for delivering a conclusive genetic diagnosis for customers having neurodevelopmental abnormalities when you look at the period of next-generation sequencing.Grade II and III gliomas tend to be heterogeneous and aggressive conditions. More cost-effective prognosis models and treatment methods are needed. This study aims to construct a new threat design and propose a unique strategy for https://parasite-receptor.com/index.php/analyzing-connection-between-principal-anastomosis-versus-hartmanns-procedure-in/ level II and III gliomas. The information had been downloaded through the Cancer Genome Atlas (TCGA), the Gene Expression Omnibus (GEO), gene set enrichment analysis (GSEA), and also the EMTome website for evaluation. The Human Cell Landscape web site and also the Genomics of Drug Sensitivity in Cancer web site were utilized for single-cell evaluation and medicine susceptibility evaluation. Gene put enrichment analysis, gene purpose enrichment analysis, univariate and multivariate Cox regression analyses, Pearson's correlation analysis, log-rank test, Kaplan-Meier survival evaluation, and ROC evaluation were performed. We constructed an immune-related prognostic model linked to the isocitrate dehydrogenase 1 (IDH1) mutation condition. By examining the immune microenvironment of patients with different risk results, we discovered that high-risk patB1/TGFBR1 inhibitor and PD-1/PD-L1 inhibitor for quality II and III gliomas.Background Hypoxanthine-guanine phosphoribosyltransferase (HPRT1) deficiency is an inborn mistake of purine kcalorie burning responsible for Lesch-Nyhan syndrome (LNS). The disease is inherited in an X-linked recessive manner and predominantly affects male individuals. Feminine people can carry a mutation as heterozygotes, but typically, they have been asymptomatic because of the arbitrary inactivation of this affected allele. However, although rare, heterozygote feminine individuals may manifest LNS with full faculties.

94 and an average absolute percentage error (AAPE) of 8.6%. The developed ANN model outperformed four existing models with the lowest AAPE and highest R value.This study aimed to elucidate changes in volatile, phenolic, and oenological profiles of wines vinified from Pulsed Electric Fields (PEF)-treated and untreated Merlot grapes during bottle storage of up to 150, 90, and 56 days at 4 °C, 25 °C, and 45 °C, respectively, through chemometrics technique. Wines produced from untreated grapes and those PEF-treated at four different processing conditions (electric field strength 33.1 and 41.5 kV/cm and energy inputs between 16.5 and 49.4 kJ/kg) were used for the bottle storage study. Results showed that hydroxycinnamic and hydroxybenzoic acids in all stored wines, regardless vinified from untreated and PEF-treated grapes, increased as a function of time and temperature, while anthocyanins and selected esters (e.g., ethyl butanoate) decreased. Extreme storage temperature, at 45 °C particularly, resulted in a higher amount of linalool-3, 7-oxide in all stored wines. After prolonged storage, all wines produced from grapes PEF-treated with four different processing conditions were shown to favor high retention of phenolics after storage but induced faster reduction of anthocyanins when compared to wines produced from untreated grapes. Moreover, some volatiles in wines vinified using PEF-treated grapes, such as citronellol and 2-phenylethyl acetate, were found to be less susceptible towards degradation during prolonged storage. Production of furans was generally lower in most stored wines, particularly those produced from PEF-treated grapes at higher energy inputs (>47 kJ/kg). Overall, PEF pre-treatment on grapes may improve storage and temperature stability of the obtained wines.Epidemiological data suggest that as many as 0.66% of adult women and 0.17% of adult men in the western world may suffer the subjective experience of being group-stalked ('gang stalked') at some point in their lives. Yet the gang stalking experience has been subject to little scientific study. This paper reports an attempt to elicit the core phenomena involved in gang-stalking by allowing them to emerge de novo through the qualitative analysis of accounts of individuals who describe being gang-stalked. Fifty descriptions of gang-stalking that satisfied study inclusion criteria were identified from the internet and subjected to content analysis. https://www.selleckchem.com/products/kp-457.html Twenty-four core phenomena were elicited, together with 11 principal sequelae of the experience of being gang-stalked. These were then divided into groups, producing a framework for the phenomena of the gang-stalking experience. The results were compared with frequencies of the same categories of experience then extracted from the original data of the only previous study on gang-stalking phenomena. Whilst the methodology of the current study was more rigorous, the core phenomena were similar in each. The current study confirmed the seriousness of the sequelae of the gang-stalking experience. These support the need for further exploration of the phenomenon, for which this study forms a basis.To realize an ultra-low-power and low-noise instrumentation amplifier (IA) for neural and biopotential signal sensing, we investigate two design techniques. The first technique uses a noise-efficient DC servo loop (DSL), which has been shown to be a high noise contributor. The proposed approach offers several advantages (i) both the electrode offset and the input offset are rejected, (ii) a large capacitor is not needed in the DSL, (iii) by removing the charge dividing effect, the input-referred noise (IRN) is reduced, (iv) the noise from the DSL is further reduced by the gain of the first stage and by the transconductance ratio, and (v) the proposed DSL allows interfacing with a squeezed-inverter (SQI) stage. The proposed technique reduces the noise from the DSL to 12.5% of the overall noise. The second technique is to optimize noise performance using an SQI stage. Because the SQI stage is biased at a saturation limit of 2VDSAT, the bias current can be increased to reduce noise while maintaining low power consumption. The challenge of handling the mismatch in the SQI stage is addressed using a shared common-mode feedback (CMFB) loop, which achieves a common-mode rejection ratio (CMRR) of 105 dB. Using the proposed technique, a capacitively-coupled chopper instrumentation amplifier (CCIA) was fabricated using a 0.18-µm CMOS process. The measured result of the CCIA shows a relatively low noise density of 88 nV/rtHz and an integrated noise of 1.5 µVrms. These results correspond to a favorable noise efficiency factor (NEF) of 5.9 and a power efficiency factor (PEF) of 11.4.LIN28 inhibits let-7 miRNA maturation which prevents cell differentiation and promotes proliferation. We hypothesized that the LIN28-let-7 axis regulates proliferation-associated genes in sheep trophectoderm in vivo. Day 9-hatched sheep blastocysts were incubated with lentiviral particles to deliver shRNA targeting LIN28 specifically to trophectoderm cells. At day 16, conceptus elongation was significantly reduced in LIN28A and LIN28B knockdowns. Let-7 miRNAs were significantly increased and IGF2BP1-3, HMGA1, ARID3B, and c-MYC were decreased in trophectoderm from knockdown conceptuses. Ovine trophoblast (OTR) cells derived from day 16 trophectoderm are a useful tool for in vitro experiments. Surprisingly, LIN28 was significantly reduced and let-7 miRNAs increased after only a few passages of OTR cells, suggesting these passaged cells represent a more differentiated phenotype. To create an OTR cell line more similar to day 16 trophectoderm we overexpressed LIN28A and LIN28B, which significantly decreased let-7 miRNAs and increased IGF2BP1-3, HMGA1, ARID3B, and c-MYC compared to control. This is the first study showing the role of the LIN28-let-7 axis in trophoblast proliferation and conceptus elongation in vivo. These results suggest that reduced LIN28 during early placental development can lead to reduced trophoblast proliferation and sheep conceptus elongation at a critical period for successful establishment of pregnancy.

erogeneity. In conclusion, the results presented here showed that the dynamics of microbial fermentation can be used to identify the sources of variability and evidence the need for better fermentation technologies that favor the production of reproducible high-quality cocoa beans. Copyright © 2020 Pacheco-Montealegre, Dávila-Mora, Botero-Rute, Reyes and Caro-Quintero.We consider the problem of incorporating evolutionary information (e.g., taxonomic or phylogenic trees) in the context of metagenomics differential analysis. Recent results published in the literature propose different ways to leverage the tree structure to increase the detection rate of differentially abundant taxa. Here, we propose instead to use a different hierarchical structure, in the form of a correlation-based tree, as it may capture the structure of the data better than the phylogeny. We first show that the correlation tree and the phylogeny are significantly different before turning to the impact of tree choice on detection rates. Using synthetic data, we show that the tree does have an impact smoothing p-values according to the phylogeny leads to equal or inferior rates as smoothing according to the correlation tree. https://www.selleckchem.com/products/cx-5461.html However, both trees are outperformed by the classical, non-hierarchical, Benjamini-Hochberg (BH) procedure in terms of detection rates. Other procedures may use the hierarchical structure with profit but do not control the False Discovery Rate (FDR) a priori and remain inferior to a classical Benjamini-Hochberg procedure with the same nominal FDR. On real datasets, no hierarchical procedure had significantly higher detection rate that BH. Intuition advocates that the use of hierarchical structures should increase the detection rate of differentially abundant taxa in microbiome studies. However, our results suggest that current hierarchical procedures are still inferior to standard methods and more effective procedures remain to be invented. Copyright © 2020 Bichat, Plassais, Ambroise and Mariadassou.Natural products have traditionally been discovered through the screening of culturable microbial isolates from diverse environments. The sequencing revolution allowed the identification of dozens of biosynthetic gene clusters (BGCs) within single bacterial genomes, either from cultured or uncultured strains. However, we are still far from fully exploiting the microbial reservoir, as most of the species are non-model organisms with complex regulatory systems that can be recalcitrant to engineering approaches. Genomic and metagenomic data produced by laboratories worldwide covering the range of natural and artificial environments on Earth, are an invaluable source of raw information from which natural product biosynthesis can be accessed. In the present work, we describe the environmental distribution and evolution of the abyssomicin BGC through the analysis of publicly available genomic and metagenomic data. Our results demonstrate that the selection of a pathway-specific enzyme to direct genome mining is an excellent strategy; we identified 74 new Diels-Alderase homologs and unveiled a surprising prevalence of the abyssomicin BGC within terrestrial habitats, mainly soil and plant-associated. We also identified five complete and 12 partial new abyssomicin BGCs and 23 new potential abyssomicin BGCs. Our results strongly support the potential of genome and metagenome mining as a key preliminary tool to inform bioprospecting strategies aimed at the identification of new bioactive compounds such as -but not restricted to- abyssomicins. Copyright © 2020 Iglesias, Latorre-Pérez, Stach, Porcar and Pascual.Listeria monocytogenes is a foodborne pathogen with a high mortality rate in humans. This study aimed to identify the pathogenic potential of L. monocytogenes isolated from ready-to-eat (RTE) foods and pasteurized milk in China on the basis of its phenotypic and genotypic characteristics. Approximately 7.7% (44/570) samples tested positive for L. monocytogenes among 10.8% (39/360) RTE and 2.4% (5/210) pasteurized milk samples, of which 77.3% (34/44) had 95% isolates were susceptible to 16 antimicrobials; however, 60.4 and 22.9% isolates were intermediately resistant to streptomycin and ciprofloxacin, respectively. The results show that several isolates harbor LIPI-3 and LIPI-4 genes, which may be a possible transmission route for Listeria infections in consumers. Copyright © 2020 Chen, Chen, Wang, Wu, Cheng, Zhang, Sun, Xue, Zeng, Lei, Pang, Ye, Wu, Zhang, Wu, Li and Kou.Mitochondria and peroxisomes are organelles whose activity is intimately associated and that play fundamental roles in development. In the model fungus Podospora anserina, peroxisomes and mitochondria are required for different stages of sexual development, and evidence indicates that their activity in this process is interrelated. Additionally, sexual development involves precise regulation of peroxisome assembly and dynamics. Peroxisomes and mitochondria share the proteins mediating their division. The dynamin-related protein Dnm1 (Drp1) along with its membrane receptors, like Fis1, drives this process. Here we demonstrate that peroxisome and mitochondrial fission in P. anserina depends on FIS1 and DNM1. We show that FIS1 and DNM1 elimination affects the dynamics of both organelles throughout sexual development in a developmental stage-dependent manner. Moreover, we discovered that the segregation of peroxisomes, but not mitochondria, is affected upon elimination of FIS1 or DNM1 during the division of somatic hyphae and at two central stages of sexual development-the differentiation of meiocytes (asci) and of meiotic-derived spores (ascospores). Furthermore, we found that FIS1 and DNM1 elimination results in delayed karyogamy and defective ascospore differentiation. Our findings reveal that sexual development relies on complex remodeling of peroxisomes and mitochondria, which is driven by their common fission machinery. Copyright © 2020 Navarro-Espíndola, Takano-Rojas, Suaste-Olmos and Peraza-Reyes.The increasing occurrence of multidrug-resistant (MDR) extended-spectrum β-lactamase- (ESBL) and/or AmpC β-lactamase-producing Enterobacteriaceae in health care systems, the environment and fresh produce is a serious concern globally. Production practices, processing and subsequent consumption of contaminated raw fruit and vegetables represent a possible human transmission route. The purpose of this study was to determine the presence of ESBL/AmpC-producing Enterobacteriaceae in complete spinach supply chains and to characterize the isolated strains phenotypically (antimicrobial resistance profiles) and genotypically (ESBL/AmpC genetic determinants, detection of class 1, 2, and 3 integrons). Water, soil, fresh produce, and contact surface samples (n = 288) from two commercial spinach production systems were screened for ESBL/AmpC-producing Enterobacteriaceae. In total, 14.58% (42/288) of the samples were found to be contaminated after selective enrichment, plating onto chromogenic media and matrix-assisted laser desorption ionization time-of-flight mass spectrometry identity confirmation of presumptive ESBL/AmpC isolates.

It is often suggested that the Greek tragedians present clinically credible pictures of mental disturbance. https://www.selleckchem.com/products/dzd9008.html For instance, some modern interpreters have compared the process by which Cadmus brings Agave back to sanity in Euripides' Bacchae with modern psychotherapy. But a reading of medical writers' views on the psychological dimension of medicine offers little evidence for believing that these scenes reflect the practices of late fifth-century Athenian doctors, for whom verbal cures are associated with older traditions of non-rational thought, and thus are scorned in favor of more "scientific cures" based on diet or medication. This paper will argue that Athenian tragedians, working from older traditions that advocated verbal cures for some mental ailments, do understand the potential psychological effects that their work can have on audiences, since tragedy requires psychological interaction with its audience in order to be effective. From a close reading of select scenes in Euripidean tragedy, this paper suggests that the experiences of the characters who experience suffering in Euripides' Heracles and Bacchae are analogues of the experiences undergone by the spectators of tragedy at large. Parallels are made between the way that Agave and Heracles are both talked back to sanity by looking upon what has happened, and the way that tragedians make their audiences observe lamentations and meditations that follow the central tragic act, to help them return from the intense emotion provoked, perhaps, by the violence they have seen.The m7G cap marks the 5' end of all eukaryotic mRNAs, but there are also capped ends that map downstream within spliced exons. A portion of the mRNA transcriptome undergoes a cyclical process of decapping and recapping, termed cap homeostasis, which impacts the translation and stability of these mRNAs. Blocking cytoplasmic capping results in the appearance of uncapped 5' ends at native cap sites but also near downstream cap sites. If translation initiates at these sites the products would lack the expected N-terminal sequences, raising the possibility of a link between mRNA recapping and proteome complexity. We performed a shotgun proteomics analysis on cells carrying an inducible inhibitor of cytoplasmic capping. A total of 21 875 tryptic peptides corresponding to 3565 proteins were identified in induced and uninduced cells. Of these, only 29 proteins significantly increased, and 28 proteins significantly decreased, when cytoplasmic capping was inhibited, indicating mRNA recapping has little overall impact on protein expression. In addition, overall peptide coverage per protein did not change significantly when cytoplasmic capping was inhibited. Together with previous work, our findings indicate cap homeostasis functions primarily in gating mRNAs between translating and non-translating states, and not as a source of proteome complexity.Several neurodegenerative diseases of humans and animals are caused by the misfolded prion protein (PrPSc), a self-propagating protein infectious agent that aggregates into oligomeric, fibrillar structures and leads to cell death by incompletely understood mechanisms. Work in multiple biological model systems, from simple baker's yeast to transgenic mouse lines, as well as in vitro studies, has illuminated molecular and cellular modifiers of prion disease. In this review, we focus on intersections between PrP and the proteostasis network, including unfolded protein stress response pathways and roles played by the powerful regulators of protein folding known as protein chaperones. We close with analysis of promising therapeutic avenues for treatment enabled by these studies.Intercalation allows cells to exchange positions in a spatially oriented manner in an array of diverse processes, spanning convergent extension in embryonic gastrulation to the formation of tubular organs. However, given the co-occurrence of cell intercalation and changes in cell shape, it is sometimes difficult to ascertain their respective contribution to morphogenesis. A well-established model to analyse intercalation, particularly in tubular organs, is the Drosophila tracheal system. There, fibroblast growth factor (FGF) signalling at the tip of the dorsal branches generates a 'pulling' force believed to promote cell elongation and cell intercalation, which account for the final branch extension. Here, we used a variety of experimental conditions to study the contribution of cell elongation and cell intercalation to morphogenesis and analysed their mutual requirements. We provide evidence that cell intercalation does not require cell elongation and vice versa. We also show that the two cell behaviours are controlled by independent but simultaneous mechanisms, and that cell elongation is sufficient to account for full extension of the dorsal branch, while cell intercalation has a specific role in setting the diameter of this structure. Thus, rather than viewing changes in cell shape and cell intercalation as just redundant events that add robustness to a given morphogenetic process, we find that they can also act by contributing to different features of tissue architecture.The ubiquitin-proteasome system (UPS) is responsible for the rapid targeting of proteins for degradation at 26S proteasomes and requires the orchestrated action of E1, E2 and E3 enzymes in a well-defined cascade. F-box proteins (FBPs) are substrate-recruiting subunits of Skp1-cullin1-FBP (SCF)-type E3 ubiquitin ligases that determine which proteins are ubiquitinated. To date, around 70 FBPs have been identified in humans and can be subdivided into distinct families, based on the protein-recruiting domains they possess. The FBXL subfamily is defined by the presence of multiple leucine-rich repeat (LRR) protein-binding domains. But how the 22 FBPs of the FBXL family achieve their individual specificities, despite having highly similar structural domains to recruit their substrates, is not clear. Here, we review and explore the FBXL family members in detail highlighting their structural and functional similarities and differences and how they engage their substrates through their LRRs to adopt unique interactomes.

A small set of miRNAs and five siRNAs were suggested as the possible efficient candidates with a high affinity to the SARS-CoV-2 genome and low side effects. The suggested candidates are promising therapeutics for the experimental evaluations and may speed up the procedure of treatment design. Materials and implementations are available at https//github.com/nrohani/SARS-CoV-2.
Integrative medicine is a key framework for the treatment of chronic medical conditions, particularly chronic pain conditions. The COVID-19 pandemic prompted rapid implementation of telehealth services.

We present outcomes of a complete and rapid transition to telehealth visits at an outpatient integrative medicine center in the Southeastern United States.

Patients and administrative staff took surveys comparing telehealth to in-person visits within four weeks of our clinic's transition to telehealth and three months later. Beginning four weeks after the clinic's telehealth conversion in March 2020, patients who had a telehealth visit at the center completed a survey about their telehealth experience and another survey three months later.

Patient quality judgements significantly favored telehealth at baseline, B = .77 [0.29 - 1.25], SE = .25,
(712) = 3.15, p = .002, and increased at three months, B = .27 [-0.03 - 0.57], SE = .15,
(712) = 1.76, p = .079. Telehealth technology usability and distanceond the COVID-19 pandemic.
We report converging mixed-method data on the successful and sustained implementation of telehealth with associated policy and clinical implications during and beyond the COVID-19 pandemic.Exosomes are extracellular vesicles released from numerous types of cells that are involved in multiple tumors development. Exosomes contribute to the modulation of tumor microenvironment (TME) through intercellular communication. As essential immune stromal cells in the TME, tumor-associated macrophages (TAMs) participate in tumor development by mediating angiogenesis, metastasis, chemoresistance, and immune escape. Due to communication with multiple cells in the TME, they exhibit plasticity and heterogeneity during the progress of polarization from monocytes to macrophages. Previous studies suggest that targeting TAMs is a promising therapeutic strategy; however, the detailed mechanism by which TAMs regulate tumor development still remains unclear. In this review, we provide an overview of the roles of exosomes as messengers in the communication between tumor cells and polarization of TAMs; we also describe the effects of their interaction on tumor development. Finally, we comprehensively discussed the potential application of exosomes as the promising tumor immunotherapy strategy.Immune checkpoint inhibitors (ICIs) as monotherapy in different solid tumors showed an early detrimental effect in a subset of patients reflected by the early crossover of the progression-free survival (PFS) curves. Currently, combination therapies with ICIs added to chemotherapy or targeted therapy are expanding the landscape of metastatic solid tumors. We have examined the benefits and risks of adding ICIs to the standard of care (SOC) versus SOC alone. A search of randomized clinical trials (RCTs) comparing ICIs combinations versus the corresponding SOC in different metastatic tumors according to the PRISMA guidelines was performed. Selected endpoints included PFS, time-to-response (TTR), overall survival (OS), overall response rate (ORR), and ≥ grade 3 adverse events (AEs). Subgroup analyses based on backbone treatment and tumor type were included. A total of 10536 patients (19 studies) were included (ICIs-arm 5596 patients; SOC-arm 4940 patients). Globally, PFS, OS, and ORR results favored ICIs-arm. No differences in terms of TTR were found between arms. ICI-arm was associated with a slight increase of ≥ G3 AEs (relative risk 1.07). The results in multiple myeloma patients are controversial in favor of ICIs combinations. https://www.selleckchem.com/products/nutlin-3a.html Adding ICIs to SOC benefits a greater number of patients, prolonging survival with no early detrimental effect. The toxicity profile is safe, with a mild increase of high-grade manageable AEs.With the iPad-mediated cognitive assessment gaining popularity with school districts and the need for alternative modes for training and instruction during this COVID-19 pandemic, school psychology training programs will need to adapt to effectively train their students to be competent in administering, scoring, an interpreting cognitive assessment instruments. This manuscript describes a mixed methods study of graduate students learning both the traditional and digital format (Q-interactive) of the WISC-V, with the goal of improving training methods and reducing administration and scoring errors. Results indicated that more errors are made on the traditional format than on the digital format, but the errors that did occur on the digital format were on subtests that require clinical acumen. Q-interactive did not reduce errors related to more complex judgments and nuanced scoring. The participating graduate students were surveyed regarding their perceptions of each format, and they revealed a majority preference for the digital format. Training implications are discussed, and specific suggestions provided for how training programs may respond to our current situation by integrating Q-interactive into their assessment courses.
Progress in electronic learning (e-learning) and health sciences education is an indicator of the national and international efforts to achieve sustainable development goals regarding good health and quality education. The objective of the current study was to describe research volume and trends on e-learning in the health sciences education.

A bibliometric methodology was adopted. The study period was from database inception until December 31, 2020. The data was downloaded from Scopus as a "csv" file. The data was analyzed to reveal prominent contributing countries, institution, authorship patterns, the degree of collaboration, international research collaboration, prominent sources for publications, frequent author keywords, the impact of research in terms of citations, and healthcare groups targeted in research.

In total, 4576 records were retrieved. The analysis revealed an increasing growth in number of publications with time. There was a sharp peak in 2020. Recent literature on e-learning in health education included keywords such as flipped classroom, mobile learning, blended learning, and COVID-19.