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3 mins ago


The identification and proper characterization of pathologic renal intratubular casts can be an arduous task, especially since they often admixed with non-pathologic casts, obfuscating debris and inflammation. The list of pathologic intratubular casts is long, and they can be easily missed or misdiagnosed without a thorough understanding of their pathophysiology and morphologic variety. Correct characterization of tubular casts is important since each cast type has a unique pathogenic mechanism, with specific treatment and prognostic implications. This review discusses the clinicopathologic characteristics of the six most common pathologic casts light chain, hemoglobin, myoglobin, red cell, neutrophilic and bile casts. We also discuss hyaline and uromodulin casts, the commonly encountered "benign" cast types that share certain histologic features with pathologic casts. We limit the discussion to proteinaceous and cellular intratubular casts, with crystalline casts discussed in a separate review within the same journal issue. While not exhaustive, this review covers pathogenesis, clinical and prognostic significance, and a practical discussion of the histomorphologic spectrum of each cast type, along with commonly encountered pitfalls. Hyperaemia-free indices have been gaining traction in recent times due to the practical advantages they offer over the fractional flow reserve (FFR) in the evaluation of angiographically intermediate coronary lesions. More recently, a new hyperaemia-free index, the resting full-cycle ratio (RFR), was described and found to correlate closely with the instantaneous wave-free ratio (iFR). The comparison between FFR and these hyperaemia-free indices, however, is nuanced and remains an ongoing area of debate and investigation. Herein, we highlight one of the important differences between the RFR and FFR, specifically in relation to the assessment of left main coronary lesion. We contend that the interchangeability of these indices cannot always be assumed and clinicians need to be aware of these limitations in their clinical practice. Crown V. All rights reserved.Spindle cell sarcoma (SCS) is a malignancy, with the most recent Surveillance, Epidemiology, and End Results (SEER) data citing a total of 250 reported cases occurring in the head and neck. Of these cases, none originated in the maxillofacial hard tissue. To the best of our knowledge, only 2 cases of primary osseous SCS of the maxillofacial region have been reported. These cases were not accounted for in the SEER data. The diagnosis of SCS requires its differentiation from other sarcomas and spindle cell neoplasms. Therefore, a comprehensive review to reinforce its inclusion in oral and maxillofacial surgeons' differential diagnosis for osseous neoplastic pathology is desired. In the present case report, we have described a maxillary SCS in a patient with an initial diagnosis of a spindle cell lesion of uncertain biologic behavior. We reviewed the data for SCS, including the epidemiologic data, diagnostic challenges, clinical and radiographic presentations, prognostic indicators, and treatment. PURPOSE Osteoradionecrosis (ORN), a potentially debilitating complication of maxillofacial radiation, continues to present a challenging clinical scenario, with limited treatment options that often fail. Translational animal models that can accurately mimic the human characteristics of the condition are lacking. In the present pilot study, we aimed to characterize the effects of radiation on the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) pharmacokinetic parameters in a rabbit model of compromised maxillofacial wound healing to determine its potential as a translational model of ORN. MATERIALS AND METHODS An experimental group underwent fractionated radiation of the mandible totaling 36 Gy. At 4 weeks after irradiation, the experimental and control groups (n = 8 rabbits each) underwent a surgical procedure to create a critical size defect in the mandibular bone. DCE-MRI scans were acquired 1 week after arrival (baseline; time point 1), 4 weeks after completion of irradiation in the experimenal preclinical model of ORN. https://www.selleckchem.com/products/gsk2982772.html BACKGROUND There are increasing reports of cardiac and exercise dysfunction in adults with small, unrepaired ventricular septal defects (VSDs). The primary aim of this study was to evaluate pulmonary function in adults with unrepaired VSDs, and secondly to assess the effects of 900 μg salbutamol on lung function and exercise capacity. METHODS Young adult patients with small, unrepaired VSDs and healthy age- and gender-matched controls were included in a double-blinded, randomised, cross-over study. Participants underwent static and dynamic spirometry, impulse oscillometry, multiple breath washout, diffusion capacity for carbon monoxide, and ergometer bicycle cardiopulmonary exercise test. RESULTS We included 30 patients with VSD (age 27 ± 6 years) and 30 controls (age 27 ± 6 years). Patients tended to have lower FEV1, 104 ± 11% of predicted, compared with healthy controls, 110 ± 14% (p = 0.069). Furthermore, the patient group had lower peak expiratory flow (PEF), 108 ± 20% predicted, compared with the control group, 118 ± 17% (p = 0.039), and showed tendencies towards lower forced vital capacity and increased airway resistance compared with controls. During exercise, the patients had lower oxygen uptake, 35 ± 8 ml/min/kg (vs 47 ± 7 ml/min/kg, p  less then  0.001), minute ventilation, 1.5 ± 0.5 l/min/kg (vs 2.1 ± 0.3 l/min/kg, p  less then  0.001) and breath rate, 48 ± 11 breaths/min (vs 55 ± 8 breaths/min, p = 0.008), than controls. CONCLUSION At rest, young adults with unrepaired VSDs are no different in pulmonary function from controls. However, when the cardiorespiratory system is stressed, VSD patients demonstrate significantly impaired minute ventilation and peak oxygen uptake, which may be early signs of parenchymal dysfunction and restrictive airway disease. These abnormalities were unaffected by the inhalation of salbutamol.

9 mins ago


Defining mathematical terms and objects is a constant issue in ecology; often definitions are absent, erroneous, or imprecise. Through a bibliographic prospection, we show that this problem appears in macro-ecology (biogeography and community ecology) where the lack of definition for the sigmoid class of functions results in difficulties of interpretation and communication. In order to solve this problem and to help harmonize papers that use sigmoid functions in ecology, herein we propose a comprehensive definition of these mathematical objects. In addition, to facilitate their use, we classified the functions often used in the ecological literature, specifying the constraints on the parameters for the function to be defined and the curve shape to be sigmoidal. Finally, we interpreted the different properties of the functions induced by the definition through ecological hypotheses in order to support and explain the interest of such functions in ecology and more precisely in biogeography.
Although patterns of biodiversity across the globe are well studied, there is still a controversial debate about the underlying mechanisms and their generality across biogeographic scales. In particular, it is unclear to what extent diversity patterns along environmental gradients are directly driven by abiotic factors, such as climate, or indirectly mediated through biotic factors, such as resource effects on consumers.

Andes, Southern Ecuador; Mt. https://www.selleckchem.com/products/AZD8931.html Kilimanjaro, Tanzania.

We studied the diversity of fleshy-fruited plants and avian frugivores at the taxonomic level, that is, species richness and abundance, as well as at the level of functional traits, that is, functional richness and functional dispersion. We compared two important biodiversity hotspots in mountain systems of the Neotropics and Afrotropics. We used field data of plant and bird communities, including trait measurements of 367 plant and bird species. Using structural equation modeling, we disentangled direct and indirect effects of climatemportance of bottom-up mechanisms for the taxonomic diversity of consumers, suggesting the importance of active resource tracking. Our results also suggest that it might be difficult to identify signals of ecological fitting between functional plant and animal traits across biogeographic regions, since different species groups may respond to different climatic drivers. This decoupling between resource and consumer communities could increase under future climate change if plant and animal communities are consistently related to distinct climatic drivers.Whether or not biogeographic rules dealing with spatial patterns of animal body sizes are valid for ectotherms is controversial. As the ectotherms grow all their lives, we explored the role of age and annual growth rate in body size variation in Phrynocephalus przewalskii in northern China. Morphological data were collected from 11 populations across a broad geographic gradient. Correlations between age, sex, climatic factors, and body size were analyzed using generalized linear model (GLM) and generalized linear mixed model (GLMM). GLM analysis indicated that the general body size of both sexes and the appendage size of females increased significantly with increasing temperature; however, the coefficient of determination was very small. GLMM analysis indicated that body size only correlated with age, whereas appendage size was affected by age, temperature, rainfall, and sunshine. Annual growth rates were positively correlated with temperature. We concluded that body size variation was mainly caused by age structure and plasticity of the growth rate in P. przewalskii and did not follow Bergmann's rule; however, females followed Allen's rule. Future studies to investigate the effect of energy restriction are needed to further understand the relationship between growth rate and body size. We also suggest that further studies on thermal advantage and sexual selection may be helpful to understand appendage size variation in P. przewalskii.Climate and environmental condition drive biodiversity at many levels of biological organization, from populations to ecosystems. Combined with paleoecological reconstructions, palaeogenetic information on resident populations provides novel insights into evolutionary trajectories and genetic diversity driven by environmental variability. While temporal observations of changing genetic structure are often made of sexual populations, little is known about how environmental change affects the long-term fate of asexual lineages. Here, we provide information on obligately asexual, triploid Daphnia populations from three Arctic lakes in West Greenland through the past 200-300 years to test the impact of environmental change on the temporal and spatial population genetic structure. The contrasting ecological state of the lakes, specifically regarding salinity and habitat structure may explain the observed lake-specific clonal composition over time. Palaeolimnological reconstructions show considerable regional environmental fluctuations since 1,700 (the end of the Little Ice Age), but the population genetic structure in two lakes was almost unchanged with at most two clones per time period. Their local populations were strongly dominated by a single clone that has persisted for 250-300 years. We discuss possible explanations for the apparent population genetic stability (a) persistent clones are general-purpose genotypes that thrive under broad environmental conditions, (b) clonal lineages evolved subtle genotypic differences unresolved by microsatellite markers, or (c) epigenetic modifications allow for clonal adaptation to changing environmental conditions. Our results motivate research into the mechanisms of adaptation in these populations, as well as their evolutionary fate in the light of accelerating climate change in the polar regions.
As global climate change alters drought regimes, rapid evolution of traits that facilitate adaptation to drought can rescue populations in decline. The evolution of phenological advancement can allow plant populations to escape drought, but evolutionary responses in phenology can vary across a species' range due to differences in drought intensity and standing genetic variation.

, a perennial herb spanning a broad climatic gradient, recently experienced a period of record drought. Here, we used a resurrection study comparing flowering time and stem height at first flower of pre-drought ancestors and post-drought descendants from northern-edge, central, and southern-edge populations in a common environment to examine the evolution of drought escape across the latitudinal range.

Contrary to the hypothesis of the evolution of advanced phenology in response to recent drought, flowering time did not advance between ancestors and descendants in any population, though storage condition and maternal effects could have impacted these results.

52 mins ago


Macaque monkeys are an important animal model where invasive investigations can lead to a better understanding of the cortical organization of primates including humans. However, the tools and methods for noninvasive image acquisition (e.g. MRI RF coils and pulse sequence protocols) and image data preprocessing have lagged behind those developed for humans. To resolve the structural and functional characteristics of the smaller macaque brain, high spatial, temporal, and angular resolutions combined with high signal-to-noise ratio are required to ensure good image quality. To address these challenges, we developed a macaque 24-channel receive coil for 3-T MRI with parallel imaging capabilities. This coil enables adaptation of the Human Connectome Project (HCP) image acquisition protocols to the in-vivo macaque brain. In addition, we adapted HCP preprocessing methods to the macaque brain, including spatial minimal preprocessing of structural, functional MRI (fMRI), and diffusion MRI (dMRI). The coil provides the necessary high signal-to-noise ratio and high efficiency in data acquisition, allowing four- and five-fold accelerations for dMRI and fMRI. Automated FreeSurfer segmentation of cortex, reconstruction of cortical surface, removal of artefacts and nuisance signals in fMRI, and distortion correction of dMRI all performed well, and the overall quality of basic neurobiological measures was comparable with those for the HCP. Analyses of functional connectivity in fMRI revealed high sensitivity as compared with those from publicly shared datasets. Tractography-based connectivity estimates correlated with tracer connectivity similarly to that achieved using ex-vivo dMRI. The resulting HCP-style in vivo macaque MRI data show considerable promise for analyzing cortical architecture and functional and structural connectivity using advanced methods that have previously only been available in studies of the human brain. While the deleterious effects of acute ethyl alcohol intoxication on executive control are well-established, the underlying spatiotemporal functional mechanisms remain largely unresolved. In addition, since the effects of alcohol are noticeable to participants, isolating the effect of the substance from those related to expectation represents a major challenge. We addressed these issues using a double-blind, randomized, parallel, placebo-controlled experimental design comparing the behavioral and electrical neuroimaging acute effects of 0.6 vs 0.02g/kg alcohol intake recorded in 65 healthy adults during an inhibitory control Go/NoGo task. Topographic ERP analyses of covariance with self-reported dose expectations allowed to dissociate their neurophysiological effects from those of the substance. While alcohol intoxication increased response time variability and post-error slowing, bayesian analyses indicated that it did not modify commission error rates. Functionally, alcohol induced topographic modulation over the periods of the stimulus-locked N2 and P3 event-related potential components, arising from pre- supplementary motor and anterior cingulate areas. In contrast, alcohol decreased the strength of the response-locked anterior cingulate error-related component but not its topography. This pattern indicated that alcohol had a locally specific influence within the executive control network, but disrupted performance monitoring processes via global strength- based mechanisms. We further revealed that alcohol-related expectations induced temporally specific functional modulations on the early N2 stimulus-locked medio-lateral prefrontal activity, a processing phase preceding those influenced by the actual alcohol intake. Our collective findings thus not only revealed the mechanisms underlying alcohol-induced impairments in impulse control and error processing, but also dissociated substance- from expectations- related functional effects. In humans, each hemisphere comprises an overlay of two visuotopic maps of the contralateral visual field, one from each eye. https://www.selleckchem.com/products/4-hydroxynonenal.html Is the capacity of the visual cortex limited to these two maps or are plastic mechanisms available to host more maps? We determined the cortical organization of the visual field maps in a rare individual with chiasma hypoplasia, where visual cortex plasticity is challenged to accommodate three hemifield maps. Using high-resolution fMRI at 7T and diffusion-weighted MRI at 3T, we found three hemiretinal inputs, instead of the normal two, to converge onto the left hemisphere. fMRI-based population receptive field mapping of the left V1-V3 at 3T revealed three superimposed hemifield representations in the left visual cortex, i.e. two representations of opposing visual hemifields from the left eye and one right hemifield representation from the right eye. We conclude that developmental plasticity including the re-wiring of local intra- and cortico-cortical connections is pivotal to support the coexistence and functioning of three hemifield maps within one hemisphere. Visual working memory (VWM) allows for keeping visual information available for upcoming goal-directed behavior, while new visual input is processed concurrently. Interactions between the mnemonic and perceptual systems cause VWM to affect the processing of visual input in a content-specific manner visual input that is initially suppressed from consciousness is detected faster when it matches rather than mismatches the content of VWM. It is currently under debate whether such mnemonic influences on perception occur prior to or after conscious access. To address this issue, we investigated whether VWM content modulates the neural response to visual input that remains suppressed from consciousness. We measured fMRI responses to interocularly suppressed stimuli in 20 human participants performing a delayed match-to-sample task Participants were retro-cued to memorize one of two geometrical shapes for subsequent recognition. During retention, an interocularly suppressed peripheral stimulus (the probe) was briefly presented, which was either of the cued (memorized) or uncued (not memorized) shape category. We found no evidence that VWM content modulated the neural response to the probe. Substantial evidence for the absence of this modulation was found despite leveraging a highly liberal analysis approach (1) selecting regions of interest that were particularly prone to detecting said modulation, and (2) using directional Bayesian tests favoring the presence of the hypothesized modulation. We did observe faster detection of memory-matching compared to memory-mismatching probes in a behavioral control experiment, thus validating the stimulus set. We conclude that VWM impacts the processing of visual input only once suppression is mostly alleviated.

Videos

09/24/2024

It seems like every week offers a different twist to the 2024 campaign—some predicted moments and some not. The upcoming weeks are no different, with the Republican Presidential candidate facing the possibility of immediately being thrown into jail and the Democratic candidate facing the same situation that took out her predecessor.
On this episode of Perspective, Scottie Nell Hughes talks the upcoming presidential debate and Trumps sentencing with her panel (Bjorn Handeen, strategist, McShane LLC political consultants; Lionel, attorney & media analyst; Larry Ward, Chairman of Constitutional Rights PAC)

Welcome to The Daily Wrap Up, a concise show dedicated to bringing you the most relevant independent news, as we see it, from the last 24 hours.

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09/13/2024

On this episode of Direct Impact, Rick Sanchez delves into the latest geopolitical developments and their far-reaching implications. With expert analysis from Ghadi Francis and Elijah Magnier, Sanchez explores Ukraine’s precarious position and the potential US authorization for Ukrainian missile strikes on Russian territory. The show also investigates the surprising celebrations in Jordan following an attack on Israeli soldiers and dissects the global reaction to Donald Trump’s controversial debate comments.

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09/24/2024

It seems like every week offers a different twist to the 2024 campaign—some predicted moments and some not. The upcoming weeks are no different, with the Republican Presidential candidate facing the possibility of immediately being thrown into jail and the Democratic candidate facing the same situation that took out her predecessor.
On this episode of Perspective, Scottie Nell Hughes talks the upcoming presidential debate and Trumps sentencing with her panel (Bjorn Handeen, strategist, McShane LLC political consultants; Lionel, attorney & media analyst; Larry Ward, Chairman of Constitutional Rights PAC)

Welcome to The Daily Wrap Up, a concise show dedicated to bringing you the most relevant independent news, as we see it, from the last 24 hours.

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09/13/2024

On this episode of Direct Impact, Rick Sanchez delves into the latest geopolitical developments and their far-reaching implications. With expert analysis from Ghadi Francis and Elijah Magnier, Sanchez explores Ukraine’s precarious position and the potential US authorization for Ukrainian missile strikes on Russian territory. The show also investigates the surprising celebrations in Jordan following an attack on Israeli soldiers and dissects the global reaction to Donald Trump’s controversial debate comments.

09/13/2024

On this episode of Direct Impact, Rick Sanchez dissects a contentious and dramatic presidential debate between Kamala Harris and Donald Trump. With insightful commentary and analysis from experts Craig Jardula and Angie Wong, Sanchez explores how Harris strategically baited Trump into revealing his frustration and anger, while both candidates failed to deliver substantial policy details. The show highlights key moments from the debate, including Trump’s handling of the Ukraine conflict and Harris’ provocative tactics, concluding that Harris’ approach might sway undecided voters and attract Democratic support.

09/13/2024

In this episode of Direct Impact, Rick Sanchez takes a closer look at the tangled web of global conflicts and shifting public opinions. The show kicks off with a jaw-dropping moment: a high-ranking Chinese diplomat delivers a sharp critique to former US Vice President Dick Cheney. From there, Rick dives into recent polls from Israel and Ukraine, which suggest a growing public desire to end these protracted wars. Rick is joined by Craig ‘Pasta’ Jardula of The Convo Couch to unpack the significance of these polling trends and their potential effects on media and policy. In the second half of the show, attorney and political commentator Steve Gill weighs in on the upcoming US presidential debate and what it could mean for the political landscape ahead.

Posts

3 mins ago


The identification and proper characterization of pathologic renal intratubular casts can be an arduous task, especially since they often admixed with non-pathologic casts, obfuscating debris and inflammation. The list of pathologic intratubular casts is long, and they can be easily missed or misdiagnosed without a thorough understanding of their pathophysiology and morphologic variety. Correct characterization of tubular casts is important since each cast type has a unique pathogenic mechanism, with specific treatment and prognostic implications. This review discusses the clinicopathologic characteristics of the six most common pathologic casts light chain, hemoglobin, myoglobin, red cell, neutrophilic and bile casts. We also discuss hyaline and uromodulin casts, the commonly encountered "benign" cast types that share certain histologic features with pathologic casts. We limit the discussion to proteinaceous and cellular intratubular casts, with crystalline casts discussed in a separate review within the same journal issue. While not exhaustive, this review covers pathogenesis, clinical and prognostic significance, and a practical discussion of the histomorphologic spectrum of each cast type, along with commonly encountered pitfalls. Hyperaemia-free indices have been gaining traction in recent times due to the practical advantages they offer over the fractional flow reserve (FFR) in the evaluation of angiographically intermediate coronary lesions. More recently, a new hyperaemia-free index, the resting full-cycle ratio (RFR), was described and found to correlate closely with the instantaneous wave-free ratio (iFR). The comparison between FFR and these hyperaemia-free indices, however, is nuanced and remains an ongoing area of debate and investigation. Herein, we highlight one of the important differences between the RFR and FFR, specifically in relation to the assessment of left main coronary lesion. We contend that the interchangeability of these indices cannot always be assumed and clinicians need to be aware of these limitations in their clinical practice. Crown V. All rights reserved.Spindle cell sarcoma (SCS) is a malignancy, with the most recent Surveillance, Epidemiology, and End Results (SEER) data citing a total of 250 reported cases occurring in the head and neck. Of these cases, none originated in the maxillofacial hard tissue. To the best of our knowledge, only 2 cases of primary osseous SCS of the maxillofacial region have been reported. These cases were not accounted for in the SEER data. The diagnosis of SCS requires its differentiation from other sarcomas and spindle cell neoplasms. Therefore, a comprehensive review to reinforce its inclusion in oral and maxillofacial surgeons' differential diagnosis for osseous neoplastic pathology is desired. In the present case report, we have described a maxillary SCS in a patient with an initial diagnosis of a spindle cell lesion of uncertain biologic behavior. We reviewed the data for SCS, including the epidemiologic data, diagnostic challenges, clinical and radiographic presentations, prognostic indicators, and treatment. PURPOSE Osteoradionecrosis (ORN), a potentially debilitating complication of maxillofacial radiation, continues to present a challenging clinical scenario, with limited treatment options that often fail. Translational animal models that can accurately mimic the human characteristics of the condition are lacking. In the present pilot study, we aimed to characterize the effects of radiation on the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) pharmacokinetic parameters in a rabbit model of compromised maxillofacial wound healing to determine its potential as a translational model of ORN. MATERIALS AND METHODS An experimental group underwent fractionated radiation of the mandible totaling 36 Gy. At 4 weeks after irradiation, the experimental and control groups (n = 8 rabbits each) underwent a surgical procedure to create a critical size defect in the mandibular bone. DCE-MRI scans were acquired 1 week after arrival (baseline; time point 1), 4 weeks after completion of irradiation in the experimenal preclinical model of ORN. https://www.selleckchem.com/products/gsk2982772.html BACKGROUND There are increasing reports of cardiac and exercise dysfunction in adults with small, unrepaired ventricular septal defects (VSDs). The primary aim of this study was to evaluate pulmonary function in adults with unrepaired VSDs, and secondly to assess the effects of 900 μg salbutamol on lung function and exercise capacity. METHODS Young adult patients with small, unrepaired VSDs and healthy age- and gender-matched controls were included in a double-blinded, randomised, cross-over study. Participants underwent static and dynamic spirometry, impulse oscillometry, multiple breath washout, diffusion capacity for carbon monoxide, and ergometer bicycle cardiopulmonary exercise test. RESULTS We included 30 patients with VSD (age 27 ± 6 years) and 30 controls (age 27 ± 6 years). Patients tended to have lower FEV1, 104 ± 11% of predicted, compared with healthy controls, 110 ± 14% (p = 0.069). Furthermore, the patient group had lower peak expiratory flow (PEF), 108 ± 20% predicted, compared with the control group, 118 ± 17% (p = 0.039), and showed tendencies towards lower forced vital capacity and increased airway resistance compared with controls. During exercise, the patients had lower oxygen uptake, 35 ± 8 ml/min/kg (vs 47 ± 7 ml/min/kg, p  less then  0.001), minute ventilation, 1.5 ± 0.5 l/min/kg (vs 2.1 ± 0.3 l/min/kg, p  less then  0.001) and breath rate, 48 ± 11 breaths/min (vs 55 ± 8 breaths/min, p = 0.008), than controls. CONCLUSION At rest, young adults with unrepaired VSDs are no different in pulmonary function from controls. However, when the cardiorespiratory system is stressed, VSD patients demonstrate significantly impaired minute ventilation and peak oxygen uptake, which may be early signs of parenchymal dysfunction and restrictive airway disease. These abnormalities were unaffected by the inhalation of salbutamol.

9 mins ago


Defining mathematical terms and objects is a constant issue in ecology; often definitions are absent, erroneous, or imprecise. Through a bibliographic prospection, we show that this problem appears in macro-ecology (biogeography and community ecology) where the lack of definition for the sigmoid class of functions results in difficulties of interpretation and communication. In order to solve this problem and to help harmonize papers that use sigmoid functions in ecology, herein we propose a comprehensive definition of these mathematical objects. In addition, to facilitate their use, we classified the functions often used in the ecological literature, specifying the constraints on the parameters for the function to be defined and the curve shape to be sigmoidal. Finally, we interpreted the different properties of the functions induced by the definition through ecological hypotheses in order to support and explain the interest of such functions in ecology and more precisely in biogeography.
Although patterns of biodiversity across the globe are well studied, there is still a controversial debate about the underlying mechanisms and their generality across biogeographic scales. In particular, it is unclear to what extent diversity patterns along environmental gradients are directly driven by abiotic factors, such as climate, or indirectly mediated through biotic factors, such as resource effects on consumers.

Andes, Southern Ecuador; Mt. https://www.selleckchem.com/products/AZD8931.html Kilimanjaro, Tanzania.

We studied the diversity of fleshy-fruited plants and avian frugivores at the taxonomic level, that is, species richness and abundance, as well as at the level of functional traits, that is, functional richness and functional dispersion. We compared two important biodiversity hotspots in mountain systems of the Neotropics and Afrotropics. We used field data of plant and bird communities, including trait measurements of 367 plant and bird species. Using structural equation modeling, we disentangled direct and indirect effects of climatemportance of bottom-up mechanisms for the taxonomic diversity of consumers, suggesting the importance of active resource tracking. Our results also suggest that it might be difficult to identify signals of ecological fitting between functional plant and animal traits across biogeographic regions, since different species groups may respond to different climatic drivers. This decoupling between resource and consumer communities could increase under future climate change if plant and animal communities are consistently related to distinct climatic drivers.Whether or not biogeographic rules dealing with spatial patterns of animal body sizes are valid for ectotherms is controversial. As the ectotherms grow all their lives, we explored the role of age and annual growth rate in body size variation in Phrynocephalus przewalskii in northern China. Morphological data were collected from 11 populations across a broad geographic gradient. Correlations between age, sex, climatic factors, and body size were analyzed using generalized linear model (GLM) and generalized linear mixed model (GLMM). GLM analysis indicated that the general body size of both sexes and the appendage size of females increased significantly with increasing temperature; however, the coefficient of determination was very small. GLMM analysis indicated that body size only correlated with age, whereas appendage size was affected by age, temperature, rainfall, and sunshine. Annual growth rates were positively correlated with temperature. We concluded that body size variation was mainly caused by age structure and plasticity of the growth rate in P. przewalskii and did not follow Bergmann's rule; however, females followed Allen's rule. Future studies to investigate the effect of energy restriction are needed to further understand the relationship between growth rate and body size. We also suggest that further studies on thermal advantage and sexual selection may be helpful to understand appendage size variation in P. przewalskii.Climate and environmental condition drive biodiversity at many levels of biological organization, from populations to ecosystems. Combined with paleoecological reconstructions, palaeogenetic information on resident populations provides novel insights into evolutionary trajectories and genetic diversity driven by environmental variability. While temporal observations of changing genetic structure are often made of sexual populations, little is known about how environmental change affects the long-term fate of asexual lineages. Here, we provide information on obligately asexual, triploid Daphnia populations from three Arctic lakes in West Greenland through the past 200-300 years to test the impact of environmental change on the temporal and spatial population genetic structure. The contrasting ecological state of the lakes, specifically regarding salinity and habitat structure may explain the observed lake-specific clonal composition over time. Palaeolimnological reconstructions show considerable regional environmental fluctuations since 1,700 (the end of the Little Ice Age), but the population genetic structure in two lakes was almost unchanged with at most two clones per time period. Their local populations were strongly dominated by a single clone that has persisted for 250-300 years. We discuss possible explanations for the apparent population genetic stability (a) persistent clones are general-purpose genotypes that thrive under broad environmental conditions, (b) clonal lineages evolved subtle genotypic differences unresolved by microsatellite markers, or (c) epigenetic modifications allow for clonal adaptation to changing environmental conditions. Our results motivate research into the mechanisms of adaptation in these populations, as well as their evolutionary fate in the light of accelerating climate change in the polar regions.
As global climate change alters drought regimes, rapid evolution of traits that facilitate adaptation to drought can rescue populations in decline. The evolution of phenological advancement can allow plant populations to escape drought, but evolutionary responses in phenology can vary across a species' range due to differences in drought intensity and standing genetic variation.

, a perennial herb spanning a broad climatic gradient, recently experienced a period of record drought. Here, we used a resurrection study comparing flowering time and stem height at first flower of pre-drought ancestors and post-drought descendants from northern-edge, central, and southern-edge populations in a common environment to examine the evolution of drought escape across the latitudinal range.

Contrary to the hypothesis of the evolution of advanced phenology in response to recent drought, flowering time did not advance between ancestors and descendants in any population, though storage condition and maternal effects could have impacted these results.

52 mins ago


Macaque monkeys are an important animal model where invasive investigations can lead to a better understanding of the cortical organization of primates including humans. However, the tools and methods for noninvasive image acquisition (e.g. MRI RF coils and pulse sequence protocols) and image data preprocessing have lagged behind those developed for humans. To resolve the structural and functional characteristics of the smaller macaque brain, high spatial, temporal, and angular resolutions combined with high signal-to-noise ratio are required to ensure good image quality. To address these challenges, we developed a macaque 24-channel receive coil for 3-T MRI with parallel imaging capabilities. This coil enables adaptation of the Human Connectome Project (HCP) image acquisition protocols to the in-vivo macaque brain. In addition, we adapted HCP preprocessing methods to the macaque brain, including spatial minimal preprocessing of structural, functional MRI (fMRI), and diffusion MRI (dMRI). The coil provides the necessary high signal-to-noise ratio and high efficiency in data acquisition, allowing four- and five-fold accelerations for dMRI and fMRI. Automated FreeSurfer segmentation of cortex, reconstruction of cortical surface, removal of artefacts and nuisance signals in fMRI, and distortion correction of dMRI all performed well, and the overall quality of basic neurobiological measures was comparable with those for the HCP. Analyses of functional connectivity in fMRI revealed high sensitivity as compared with those from publicly shared datasets. Tractography-based connectivity estimates correlated with tracer connectivity similarly to that achieved using ex-vivo dMRI. The resulting HCP-style in vivo macaque MRI data show considerable promise for analyzing cortical architecture and functional and structural connectivity using advanced methods that have previously only been available in studies of the human brain. While the deleterious effects of acute ethyl alcohol intoxication on executive control are well-established, the underlying spatiotemporal functional mechanisms remain largely unresolved. In addition, since the effects of alcohol are noticeable to participants, isolating the effect of the substance from those related to expectation represents a major challenge. We addressed these issues using a double-blind, randomized, parallel, placebo-controlled experimental design comparing the behavioral and electrical neuroimaging acute effects of 0.6 vs 0.02g/kg alcohol intake recorded in 65 healthy adults during an inhibitory control Go/NoGo task. Topographic ERP analyses of covariance with self-reported dose expectations allowed to dissociate their neurophysiological effects from those of the substance. While alcohol intoxication increased response time variability and post-error slowing, bayesian analyses indicated that it did not modify commission error rates. Functionally, alcohol induced topographic modulation over the periods of the stimulus-locked N2 and P3 event-related potential components, arising from pre- supplementary motor and anterior cingulate areas. In contrast, alcohol decreased the strength of the response-locked anterior cingulate error-related component but not its topography. This pattern indicated that alcohol had a locally specific influence within the executive control network, but disrupted performance monitoring processes via global strength- based mechanisms. We further revealed that alcohol-related expectations induced temporally specific functional modulations on the early N2 stimulus-locked medio-lateral prefrontal activity, a processing phase preceding those influenced by the actual alcohol intake. Our collective findings thus not only revealed the mechanisms underlying alcohol-induced impairments in impulse control and error processing, but also dissociated substance- from expectations- related functional effects. In humans, each hemisphere comprises an overlay of two visuotopic maps of the contralateral visual field, one from each eye. https://www.selleckchem.com/products/4-hydroxynonenal.html Is the capacity of the visual cortex limited to these two maps or are plastic mechanisms available to host more maps? We determined the cortical organization of the visual field maps in a rare individual with chiasma hypoplasia, where visual cortex plasticity is challenged to accommodate three hemifield maps. Using high-resolution fMRI at 7T and diffusion-weighted MRI at 3T, we found three hemiretinal inputs, instead of the normal two, to converge onto the left hemisphere. fMRI-based population receptive field mapping of the left V1-V3 at 3T revealed three superimposed hemifield representations in the left visual cortex, i.e. two representations of opposing visual hemifields from the left eye and one right hemifield representation from the right eye. We conclude that developmental plasticity including the re-wiring of local intra- and cortico-cortical connections is pivotal to support the coexistence and functioning of three hemifield maps within one hemisphere. Visual working memory (VWM) allows for keeping visual information available for upcoming goal-directed behavior, while new visual input is processed concurrently. Interactions between the mnemonic and perceptual systems cause VWM to affect the processing of visual input in a content-specific manner visual input that is initially suppressed from consciousness is detected faster when it matches rather than mismatches the content of VWM. It is currently under debate whether such mnemonic influences on perception occur prior to or after conscious access. To address this issue, we investigated whether VWM content modulates the neural response to visual input that remains suppressed from consciousness. We measured fMRI responses to interocularly suppressed stimuli in 20 human participants performing a delayed match-to-sample task Participants were retro-cued to memorize one of two geometrical shapes for subsequent recognition. During retention, an interocularly suppressed peripheral stimulus (the probe) was briefly presented, which was either of the cued (memorized) or uncued (not memorized) shape category. We found no evidence that VWM content modulated the neural response to the probe. Substantial evidence for the absence of this modulation was found despite leveraging a highly liberal analysis approach (1) selecting regions of interest that were particularly prone to detecting said modulation, and (2) using directional Bayesian tests favoring the presence of the hypothesized modulation. We did observe faster detection of memory-matching compared to memory-mismatching probes in a behavioral control experiment, thus validating the stimulus set. We conclude that VWM impacts the processing of visual input only once suppression is mostly alleviated.

1 hr ago


The Best Woodburners

The relaxation, blood pressure-lowering benefits of a wood stove have been documented. But what about the tiny sooty particles they release into the air?

New stoves are designed to be compliant with the EcoDesign directive. You can enjoy a warm and cozy home without breaking your environmental commitments.

1. Ekol Edge

The Ekol Edge is a simple-looking wood burner that doesn't scrimp on performance. It's a great choice for those who live in smoke controlled areas as it is certified with Level 5 ClearSkies certification which means it can be used with dry and seasoned wood and approved solid fuels. Its large heat output makes it a great option for larger spaces and the large fire glass provides a stunning view of your flames.

It is equipped with a modern steel frame that allows it to be used in both traditional inglenooks as well as freestanding spaces. It comes with an integrated air wash system that keeps the glass clean and avoids soot accumulation. The stove is extremely efficient, which means that it can transfer a significant amount of the heat generated into your home instead of going up the chimney.

Wood burners have come under many criticisms in recent years, as it has been proven that they cause microscopic sooty particles in the air called PM2.5, which has been linked to lung and heart problems. Modern models that are compliant with the Eco design Regulations will be less likely to create these sooty particles. They are just a small portion of the total pollution created by burning fossil fuels like coal and gas, but there is no doubt that wood burning stoves are the main source of this pollution.

It is essential to choose the right wood for the stove in order to get the most efficient heat output and combustion. Many types of wood can be used, including eucalyptus and Ash. Eucalyptus is an excellent choice since it burns quickly and produces a lot of heat, but it requires to be and properly seasoned. Beech is also a great choice, but it's difficult to manage due to its thorns.

The Ekol Adept has been designed to be able to withstand the imminent changes to regulations that have been implemented and is Defra exempt and ClearSkies rated. This means that you can use it with approved fuels as long as you follow the guidelines. It's a powerful, durable burner with a 10-year Body Warranty and a strong construction. Its heating performance is also impressive.

2. Arada Holborn 5 Widescreen

Wood burning stoves are still very popular and, despite the directive maze that surrounds them, they're not going anywhere. In fact, some groups are calling for much tighter restrictions and even a complete ban on log burners, which is why it's worth taking a look at our guide to stove pollution and regulations prior to you go shopping for an updated log fire or multifuel burner.

Arada Stoves is a company that is doing its part to ensure that woodburners remain popular. They have launched a widescreen version of their popular Holborn Multifuel/Wood Burning Stove. It's an DEFRA approved, SIA 2022 Ecodesign Ready woodburner with a huge glass door that gives a great flame picture. There is also an airwash system which prevents the accumulation of soot.

This stove is easy to use, and has a heat output rating of 4.9kW. The curvaceous lines and classic style make it suitable for both traditional and modern decor. The flat back design means it can be placed in shallower recesses and it's very easy to install a direct air system using this model to increase the efficiency even more.

Another excellent characteristic of this stove is the built-in ash dump, which makes it very easy to clean and remove ashes on a regular basis, helping to reduce the chance of odours and dust getting into the room. There are two flue adaptors (standard or pre-fabricated) depending on the type of chimney you are using, and it's accessible with the option of a remote control.

While the debate rages on about whether wood-burning stoves are beneficial to your health We can all agree that they create wonderful ambience in our homes. It is important to think about the health consequences of indoor air pollution and particulate matter. So, if you're going to install a woodburner it is recommended that you keep the door shut when you're not working on the fire. Also, you should regularly clean out the stove to ensure that the indoor air is as healthy as it can be.

3. Go Eco 5kW Plus

A woodburner provides a beautiful atmosphere to any room, it's not just relaxing to watch the flames dance, but it also helps lower blood pressure. But there's not a lot of good news. Research has shown that older stoves are dangerous because they release microscopic particles of soot that could get into your respiratory system. New regulations are in place to ensure that log stoves have higher standards. This will reduce smoke leakage, creosote accumulation and, most important, harmful gases such as carbon monoxide.

New woodburners must comply with a brand new standard and this is where the Go Eco 5kW Plus stands out, this multi-fuel stove not only meets, but surpasses the new standards. The stove features a large-screen viewing glass that allows you to see the flames clearly. It is also kept clean by an air-washing system that is powerful. This stove has an impressive rating of 80% energy efficiency and is DEFRA exempt meaning that it is able to be used in smoke-free areas. It is also SIA Ecodesign-ready. This means that it already meets European emission limits for wood burning stoves that will be in place in 2022.



As if that wasn't enough the stove comes with an air venting kit for free making it simpler than ever to install. https://click4r.com/posts/g/18791561/the-reason-why-youre-not-succeeding-at-wood-burners 's a sturdy little unit, that has been built using top-quality steel. The finish is a classic matt black and it's easy to keep clean because the body is coated in an enamel that keeps dirt and grime out.

This stove has a clearSkies label, which signifies that it was independently tested and confirmed as environmentally friendly and efficient. This goes above and beyond the basic requirements of Ecodesign. This is one of one stove on our list that carry the entire five-star ClearSkies rating.

4. Chilli Penguin Defrost

Chilli Penguin is a feisty Welsh wood burner brand with an unorthodox style that shouldn't be missed out on. They are renowned for their small multi-fuel stoves with a wide range of sizes and features. This 4.7kW model is a fantastic example of their focus on brand and shows that they can provide a top-quality product at a price that's not too expensive. This DEFRA approved woodburner can be used in Smoke Control Areas and is fully conforming to the current emission limit of 5g/hr. It also comes with level five ClearSkies credentials. It's the ideal choice for those who aren't sure where the directive will go and want to feel secure that their log burners will remain exempt from smoke control regulations.

3 hrs ago


In a world increasingly dominated by constant connectivity, the invisible battle between communication and interruption is quietly taking place. Enter the realm of jammers—devices that can disrupt and block signals from cell phones, WiFi, and even GPS systems. While the idea of a cell phone network jammer might conjure images of clandestine operations or high-tech espionage, the reality is that these tools have found a place in various everyday settings, from classrooms to vehicles, and even within our own homes.



As wireless technology continues to advance, so too does the need for controlled environments free from the distractions of mobile communication. The rise in demand for cell phone signal jammer devices reflects a growing desire to manage the flow of information and communication. Whether it's a cell phone signal jammer for cars to ensure safe driving without disruptions, a hidden cell phone jammer for discreet use, or a powerful cell phone jammer for schools aimed at enhancing focus and learning, these devices are reshaping how we interact with technology in our daily lives. In this article, we will delve into the hidden world of jammers, exploring their functionality, various applications, and the implications of their use in today's society.

Types of Cell Phone Jammers

Cell phone jammers come in a variety of types, each designed for specific applications and environments. One common type is the handheld cell phone jammer, which is portable and often used in personal scenarios. These devices typically have a short range, making them suitable for small areas such as classrooms or home settings. Users appreciate their convenience and the ability to block signals without being overly complex or bulky.

Another category includes high powered cell phone jammers used for more extensive coverage. These jammers can disrupt signals over larger areas, such as workplaces or outdoor events. They are particularly useful for controlling communication in environments where distractions need to be minimized, like during conferences or important gatherings. Despite their effectiveness, these devices can have legal restrictions depending on local laws and regulations.

In addition, specialized jammers exist for specific situations, such as vehicles and educational institutions. A cell phone signal jammer for cars is designed to neutralize signals while driving, promoting safer and less distracted travel. https://output.jsbin.com/dinajiyuxu/ Similarly, cell phone signal jammers for schools are used to limit mobile device usage in classrooms, encouraging student focus and engagement. Each type of jammer serves a unique purpose, reflecting the growing need for signal control in various contexts.

Legal and Ethical Implications

The use of jammers raises significant legal and ethical concerns. In many countries, the use of cell phone network jammers is illegal, as they interfere with legitimate communications and violate regulations set by telecommunications authorities. For instance, the Federal Communications Commission in the United States strictly prohibits the use of any device that interferes with wireless communications. This legal framework is designed to protect public safety communications and ensure that emergency services can operate without disruption.

Moreover, the ethical considerations surrounding jammers extend beyond compliance with the law. While some may argue that jammers can provide a solution for preventing distractions in settings like classrooms or workplaces, their use can infringe on individual rights and freedoms. By blocking communication, jammers not only disrupt personal conversations but can also hinder individuals' ability to access important information or seek help in emergencies. This dichotomy between potential benefits and the right to communicate highlights the complexity of deploying such devices.

Additionally, the potential for misuse of jammers poses a serious concern. From creating chaos at public events to privacy violations, the indiscriminate use of cell phone signal jammers can lead to harmful situations. The availability of various types of jammers for sale, including cheap and powerful options, raises the risk of these devices falling into the wrong hands. As technology continues to evolve, the need for clear regulations and ethical guidelines becomes increasingly critical to manage the implications of jammers effectively.

Impact on Society and Communication

The proliferation of cell phone network jammers has significant implications for society and communication. These devices, designed to interfere with cellular signals, can disrupt essential services such as emergency communications. In critical situations, where timely responses are paramount, a jammer can hinder calls for help, affecting the safety of individuals and the effectiveness of response teams. This raises ethical concerns about the unrestricted use of jammers, as the consequences can extend beyond personal inconvenience to life-threatening situations.

Moreover, jammers have increasingly found their way into various environments, such as classrooms, workplaces, and public venues. While some advocate for cell phone signal jammers for classrooms to enhance focus among students, there is a fine line between creating a conducive learning environment and infringing on personal freedoms. The balance between maintaining discipline and ensuring that individuals can stay connected when necessary is a contentious debate, highlighting the complexities of modern communication in an increasingly digital world.

Additionally, the emergence of consumer-grade jammers, such as portable and cheap cell phone signal jammers, poses challenges for regulatory bodies. As these devices become more accessible, the potential for misuse rises, affecting not only personal privacy but also the overall integrity of communication networks. Society must grapple with the ramifications of widespread jammer availability, ensuring that any measures implemented to limit their use protect both individual rights and the collective good.


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