Radical scavenger experiments and electron paramagnetic resonance indicated that both SO4•- and •OH were major reactive species during the PNT degradation. The possible degradation pathways of PNT mainly included the break of C-N and C-O bonds and further oxidation.Recently, sustainability of tourism growth has become an international issue due to environmental and economic uncertainty that needs recent researchers' focus and also requires the policymakers' attention. Therefore, the present research has examined the role of economic and environmental factors and tourism policy related to tourist arrival on the sustainability of tourism growth in China. The economic factor includes the gross domestic product (GDP), national income, and foreign direct investment (FDI), while environmental factors include carbon dioxide (CO2) emission, greenhouse gas (GHG) emission, and nitrous oxide emission. The study has extracted the data from World Development Indicators (WDI) from 1990 to 2020. The present research has employed nonlinear autoregressive distributed lagged (NARDL) to check the linkage among variables. The current study also examines the unit root using Augmented Dickey-Fuller (ADF) and Phillips-Perron (PP) tests. The results revealed that GDP, national income, tourism policy related to tourist arrival, and FDI have a positive linkage with the sustainability of tourism growth. The results also exposed that environmental factors such as CO2 emission, GHG emission, and nitrous oxide emission have a negative linkage with the sustainability of tourism growth. This study provides the guidelines to the relevant authorities and regulators in developing and implementing the regulators regarding the sustainability of tourism growth by promoting economic and environmental conditions and effective tourism policies in the country.As the COVID-19 pandemic enters its third year and the omicron variant becomes dominant, we propose an alternative strategy for dealing with COVID-19, called hybrid lockdown, that is, the combination of lockdown (the centralized and organized lockdown of the high-risk population) and free mobility (normal mobility) of the low-risk population. Such an approach will enable a country or region, especially with a high population density, to achieve significant prevention and control the effects of the COVID-19 pandemic at the least cost.Recent references discovered that lncRNAs acted roles in malignant cancer development. However, the role of MAFG-AS1 in acute myeloid leukemia (AML) development remains unknown. MAFG-AS1 and miR-147b were determined in AML cells and specimens using qRT-PCR assay. Cell proliferation was detected by CCK-8 analysis and flow cytometry was carried out to measure cell cycle. Luciferase reporter analysis was done to determine the mechanism of MAFG-AS1 and miR-147b. We noted that MAFG-AS1 was overexpressed in AML cells and in serum and bone narrow from AML compared with normal controls specimen. Elevated expression of MAFG-AS1 increased cell growth, cycle and EMT in AML cell HL-60 cell. MAFG-AS1 sponged miR-147b expression in HL-60 cell. Moreover, miR-147b was downregulated in AML cells and in serum and bone narrow from AML compared with normal control specimen. miR-147b was negatively correlated with MAFG-AS1 in the serum and bone narrow of AML cases. We illustrated that HOXA9 was one target of miR-147b and ectopic expression of MAFG-AS1 enhanced HOXA9 expression HL-60 cell. Forced expression of MAFG-AS1 induced cell growth, cycle, and EMT via promoting HOXA9. These data illustrated that MAFG-AS1 acted as one oncogenic gene and accelerated AML progression via modulating miR-147b/HOXA9 axis.In this study, the manufacture of zinc oxide nanoparticles (ZnO-NPs) was completed via the sol-gel method with Trigonella foenum-graecum L extract for the first time to function as the stabilizing and reducing agent. The obtained product was investigated by various analyzing procedures such as TGA/DTG, FT-IR, UV-Vis, XRD, and EDX/FESEM. The calcination of our product was conducted at temperatures of 400, 500, and 600 °C. In conformity to the XRD pattern, heightening the temperature of calcination caused an enlargement in the size of nanoparticles. The photocatalytic performance of ZnO-NPs was evaluated to degrade methylene blue and Eriochrome black T (EBT) dyes under UV light, which resulted in a degradation percentage of about 96% and 94%, after 90 min, respectively. There has been some evidence suggesting that the green synthesis of ZnO-NPs has increased their use in medicine. The outcomes of examining the cytotoxicity effect of this product against the Huh-7 cell line by the performance of the MTT assay were indicative of an IC50 of around 62.5 µg/mL. Finally, according to the results of the broth microdilution method, which was performed to assess the antibacterial activity of ZnO-NPs towards gram-positive and gram-negative bacteria, the value of MIC was in the range of 31 to 125 µg/mL. The obtained results from biological studies confirm the antibacterial and anticancer properties of ZnO-NPs, which are promising for applying NPs in medical fields.The occurrences of flash floods in sub-tropical climatic regions like India are ubiquitous phenomena, particularly during the monsoon season. This type of flood occurs within a short period of time and makes it distinctive from all-natural hazards, which causes huge loss of economy and causalities of life. Therefore, its prediction is crucial and one of the challenging tasks for researchers to mitigate this sustainably. Furthermore, identifying flash flood susceptible regions is the foremost responsibility in managing flood events, which helps the local administration take emergency relief operations in flood-prone regions. In September 2021, the flood in the Gandheswari river basin was the most severe compared to the past decade. The occurrences of flash floods in the lower course of the Gandheswari river has been affected riparian habitats rigorously. Thus, in this study, we proposed the bivariate logistic regression (LR) method to delineate this river basin's flash flood hazard (FFH) map. Here, sixteen flood conditioning factors were selected for modeling purposes with the help of a multicollinearity test, and a total of 71 flood points were identified from the historical dataset. The produced result was validated by six distinctive validating techniques, including receiver operating characteristics (ROC) analysis, specificity, sensitivity, positive predictive value (PPV), negative predictive value (NPV), and F-score. These techniques have shown that present modeling has high predictive performance in both training and testing dataset with the values of ROC (training-0.928, validating-0.892), specificity (training-0.911, validating-0.882), sensitivity (training-0.915, validating-0.885), PPV (training-0.912, validating-0.874), NPV (training-0.91, validating-0.875), and F-score (training-0.92, validating-0.89). Therefore, the proposed method in this and the outcome result will help the disaster manager make proper decisions to mitigate the hazardous situation and take sustainable emergency relief operations.Aquaculture with an intensive system can both increase production and the disease risk. https://www.selleckchem.com/products/crenolanib-cp-868596.html The use of antibiotics to reduce pathogens has bacterial resistance consequence. Peptides have rapidly gained more attention due to their antibacterial and immunomodulatory properties important to combat pathogens. This study aimed to determine the effectiveness of peptide hydrolysate against Aeromonas hydrophila in vitro and in vivo in Nile tilapia. The peptides obtained from fish skin collagen of tilapia, milkfish, and catfish were applied in different doses. Protein content and hydrolysis degree of the peptide were also measured. The peptides were tested in vitro using A. hydrophila. For in vivo test, The peptides and positive control treatments used A. hydrophila bacteria, while negative control treatment used a phosphate buffer saline (PBS). The results showed that all three peptide hydrolysates had similar protein content. The highest hydrolysis degree was shown by milkfish collagen hydrolysate. In vitro assay revealed that 12.5% milkfish skin collagen obtained the highest antibacterial activity. In vivo assay showed that the phagocytic activity, respiratory burst, and lysozyme activity was higher in preventive control than therapy, positive control, or negative control treatments. The growth and survival rate in preventive control was also better than positive control or therapy treatment. This study concludes that the peptide hydrolysate can inhibit the growth of A. hydrophila. Peptide hydrolysate from milkfish skin collagen at 12.5% dose was more effective in preventing the A. hydrophila infection, regarding the immune response, growth, and survival.Severe Acute Respiratory Syndrome Coronavirus 2 is the causative agent of Coronavirus Disease 2019 in humans. Among domestic animals, cats are more susceptible to SARS-CoV-2 than dogs. The detection of anti-SARS-CoV-2 antibodies in seemingly healthy cats and/or infected cats which are in close contact with infected humans has been described. The presence of animals that tested positive by serology or molecular techniques could represent a potential transmission pathway of SARS-CoV-2 that can spill over into urban wildlife. This study analyses the seroprevalence variation of SARS-CoV-2 in stray cats from different waves of outbreaks in a geographical area where previous seroepidemiological information of SARS-CoV-2 was available and investigate if SARS-CoV-2-seropositive cats were exposed to other co-infections causing an immunosuppressive status and/or a chronic disease that could lead to a SARS-CoV-2 susceptibility. For this purpose, a total of 254 stray cats from Zaragoza (Spain) were included. This analysior FeLV and 7.87% for FIV.Our findings suggest that the epidemiological role of stray cats in SARS-CoV-2 transmission is scarce, and there is no increase in seropositivity during the different waves of COVID-19 outbreaks in this group of animals. Further epidemiological surveillances are necessary to determine the risk that other animals might possess even though stray cats do not seem to play a role in transmission.Garole sheep exhibits within-breed difference in resistance to natural gastrointestinal nematode infection predominated by Haemonchus contortus. In the present study, interferon gamma gene (IFN-γ) was characterized in relation to parasitological, haematological, and immune response against H. contortus in resistant and susceptible Garole sheep. Resistant and susceptible Garole sheep were selected from the field based on consistent low faecal egg counts (FEC) for one year and single nucleotide polymorphisms (SNPs) in the IFN-γ gene. The partial amplification of IFN-γ gene (1282 bp) revealed 4 SNPs exclusively in resistant sheep and 3 SNPs were shared between resistant and susceptible Garole sheep. The selected resistant and susceptible Garole sheep were challenged with H. contortus infection. The parasitological, haematological, immunological responses, and expression of IFN-γ gene were compared between the resistant and susceptible Garole sheep. The FEC of resistant sheep was significantly (P  less then  0.05) lower than the susceptible sheep infected with H.