12)-2.66]). Total WOMAC score showed a significant difference over the time favoring HA injection (4.5 [95%CI 1.1-8]). However, no single time point showed any significant difference between groups.

This meta-analysis showed no significant difference between HA and ozone in reducing pain and improving function in patients with knee OA, although the overall results favored HA over ozone. Since previous studies have shown comparable results between HA and placebo, ozone seems to fall in the same category with more placebo effect rather than a real disease-modifier.
This meta-analysis showed no significant difference between HA and ozone in reducing pain and improving function in patients with knee OA, although the overall results favored HA over ozone. Since previous studies have shown comparable results between HA and placebo, ozone seems to fall in the same category with more placebo effect rather than a real disease-modifier.Ever since its description, anterolateral ligament (ALL) of the knee joint remains as the hotspot of controversies. Though it has been described under various descriptions, the structure gained its limelight when it was christened as anterolateral ligament by Claes in 2013. The main reason for the controversies around it is the lack of concrete evidences regarding its attachments, morphology, biomechanical aspects and radiological appearance. Similarly the role of ALL in pivot shift phenomenon also remains as a point of debate. The advocates of ALL suggest that because of its ability to modulate internal rotation and attachment to the lateral meniscus, ALL contributes to the pivot shift phenomenon. Similarly, the orientation of ALL stands as the reason for varied documentation with respect to imaging techniques. With the growing body of evidence, it is imperative to fix our stand regarding the structure because, if found to be morphologically persistent, it can be used for concomitant anterolateral stabilization along with anterior cruciate ligament reinforcement surgeries. The present review tries to systematically review the anatomy, variations in classifications, descriptions, histology, radiology and biomechanical features of ALL. At the end of the review, we would like to find the answer for the question Is ALL a distinct ligamentous structure located at the anterolateral aspect of the knee? What is the contribution of it to the tibial internal rotation stability?Patellofemoral (PF) osteoarthritis (OA) is a somewhat predominant illness, affecting up to 24% of women and 11% of men over the age of 55 years who suffer from symptomatic knee OA. The purposes of this narrative overview are to summarize the present situation of patellofemoral arthroplasty (PFA) in the treatment of solitary PF-OA, and to give an account of the clinical results of PFA for the management of solitary PF degenerative OA of the knee. A Cochrane Library and PubMed (MEDLINE) examination related to the position of PFA in PF-OA was carried out. A number of publications have encountered that PFA is an efficacious treatment for solitary PF-OA. Additionally, a systematic review described fairly good results of PFA survivorship and functional outcomes at short- and mid-run follow-up in the setting of solitary PF-OA. Success of PFA depends on accurate patient selection rather than prosthetic failure or wear. In many reports, the main cause of PFA failure is advancement of tibiofemoral OA. In contemporary times, encouraging results have been accomplished by the association of PFA and unicompartmental knee arthroplasty (UKA). In conclusion, patients with solitary PF-OA with severe anterior knee pain may be candidates for PFA. The success of the surgical procedure and the long-run survivorship of PFA are related to a good surgical technique and observation to meticulous indications and contraindications in patient selection. Newer prostheses have also played a part to ameliorated outcomes. PFA is an alternative for younger patients with solitary PF-OA.The novel corona-virus disease (COVID-19) pandemic has caused a major outbreak in more than 200 countries around the world, leading to a severe impact on the health and life of many people globally. As of mid-July 2020, more than 12 million people were infected, and more than 570,000 death were reported. Computed Tomography (CT) images can be used as an alternative to the time-consuming RT-PCR test, to detect COVID-19. In this work we propose a segmentation framework to detect chest regions in CT images, which are infected by COVID-19. We use an architecture similar to U-Net model, and train it to detect ground glass regions, on pixel level. As the infected regions tend to form a connected component (rather than randomly distributed pixels), we add a suitable regularization term to the loss function, to promote connectivity of the segmentation map for COVID-19 pixels. 2D-anisotropic total-variation is used for this purpose, and therefore the proposed model is called "TV-UNet". Through experimental results on a relatively large-scale CT segmentation dataset of around 900 images, we show that adding this new regularization term leads to 2\% gain on overall segmentation performance compared to the U-Net model. Our experimental analysis, ranging from visual evaluation of the predicted segmentation results to quantitative assessment of segmentation performance (precision, recall, Dice score, and mIoU) demonstrated great ability to identify COVID-19 associated regions of the lungs, achieving a mIoU rate of over 99\%, and a Dice score of around 86\%.In this paper we consider the signal-to-interference-and-noise ratio (SINR) optimization problem in the multi-user multi-input-single-output (MISO) uplink wireless network assisted by intelligent reflecting surface (IRS) under individual information rate constraints. We perform a comprehensive investigation on various aspects of this problem. First, under the individual rate constraints, we study its feasibility. We present a sufficient condition which guarantees arbitrary set of individual information rates. This result strengthens the feasibility condition in existing literature and is useful to the power control/energy efficiency (EE) maximization problem when IRS is present. Then, based on the penalty dual decomposition (PDD) and nonlinear equality alternative direction method of multipliers (neADMM) method, we present new algorithms to tackle the IRS configuration problems, which simultaneously involves multi-dimensional constant-modulus constraints and other additional constraints. https://www.selleckchem.com/ Note that the similar hard-core problem has recurrently appeared in various research work on IRS recently.