as, such as the cerebellum, showed significantly stronger activation compared to HCs, presumably supporting pelvic-floor motor activity to prevent UI. The novel findings of the present study provide physiological evidence of the necessity to consider non-bladder aetiologies of bladder symptoms.We report the first case of apocrine ductal carcinoma in situ (DCIS) in a female-to-male transgender individual on testosterone therapy (TT). The gender confirmation total mastectomy revealed 2 cm DCIS with apocrine cytology, high nuclear grade with associated calcification, and necrosis. Immunohistochemistry revealed the DCIS was negative for ER, positive for AR with HER2/neu overexpression (3+). This patient with negative screening mammography developed apocrine DCIS on TT, suggesting that gender-affirming hormone therapy may have advanced malignant transformation of atypical apocrine cells. This may have implications for increased surveillance within the transgender population.This study investigated the nephroprotective role of acylated ghrelin (AG) against DOX-induced nephropathy and examined whether the protection involves silent information regulator 1 (SIRT1). Rats were divided into control, control + AG, DOX, DOX + AG, DOX + AG + [D-Lys3]-GHRP-6 (a ghrelin receptor antagonist), and DOX + AG + EX-527 (a sirt1 inhibitor). DOX was given over the first 2 weeks. AG (10 ng/kg) and both inhibitors were given as 3 doses/wk for 5 weeks. https://www.selleckchem.com/products/ziritaxestat.html AG improved the structure and the function of the kidneys; down-regulated the renal expression of TGF-β1, collagen 1A1 and α-SMA; and inhibited the renal collagen deposition in the kidneys of DOX-treated rats. Concomitantly, it reduced the renal levels of ROS, MDA, TNF-α, and IL-6 and protein levels of cytochrome-c, TGF-β1, Smad3 and α-SMA in these rats. In both the control and DOX-treated rats, AG significantly increased the renal levels of SOD and GSH, decreased the expression of cleaved caspase-3 and Bax, increased the total levels and the nuclear activity of SIRT1 and reduced the deacetylation of p53, NF-κB and FOXO-31. All the effects were abolished by the concurrent administration of EX-527 and [D-Lys3]-GHRP-6. In conclusion, AG prevents DOX-induced nephropathy in SIRT1 and GSHRa1-dependent mechanism.This study aimed to compare the three index systems designed for cone-beam computed tomography (CBCT) in terms of intra- and inter-observer agreement. 117 root-filled teeth with or without periapical radiolucency from 77 of already existing CBCT images were chosen randomly. Two observers evaluated the periapical status of the selected teeth and graded the scores twice using CBCT periapical index (CBCTPAI), endodontic radiolucency index (ERI) and complex periapical index (COPI) part of the periapical and endodontic status scale (PESS), respectively. The researchers' self-agreement kappa values ranged from substantial to almost perfect. A moderate inter-observer agreement was present for the COPI and ERI, whereas a fair agreement was present for CBCTPAI. The researchers' ICC for the inter-observer reliability of CBCTPAI, ERI and COPI was 0.75, 0.77 and 0.80, respectively. COPI had the highest self-agreement and inter-observer reliability. ERI showed the highest intra-observer variation, whereas CBCTPAI showed the highest inter-observer variation.Systemic acquired resistance (SAR) is a long-lasting and broad-based resistance that can be activated following infection with (a)virulent pathogens and treatment with exogenous elicitors. Pipecolic acid (Pip), a Lys-derived non-protein amino acid, naturally occurs in many different plant species, and its N-hydroxylated derivative, N-hydroxypipecolic acid (NHP), acts as a crucial regulator of SAR. In the present study, we conducted a systemic analysis of the defence responses of a series of D,L-Pip-pretreated Cucumis sativus L. against Podosphaera xanthii (P. xanthii) and Pseudomonas syringae pv. lachrymans (Psl). The effects of D,L-Pip on ROS metabolism, defence-related gene expression, SA accumulation and activity of defence-related enzymes were evaluated. We show that exogenously applied D,L-Pip successfully induces SAR in cucumber against P. xanthii and Psl, but not Fusarium oxysporum f. sp. cucumerinum (Foc). Exogenous application of D,L-Pip via the root system is sufficient to activate the accumulation of free and conjugated salicylic acid (SA), and earlier and stronger upregulation of SAR-associated gene transcription upon P. xanthii infection. Furthermore, D,L-Pip treatment and subsequent pathogen inoculation promote hydrogen peroxide and superoxide accumulation, as well as Rboh transcription activation in cucumber plants, suggesting that D,L-Pip-triggered ROS production might be involved in enhanced defence reactions against P. xanthii. We also demonstrate that D,L-Pip pretreatment increases the activity of defence-associated enzymes, including peroxidase, chitinase and β-1,3-glucanase. The results presented in this report provide promising features of Pip as an elicitor in cucumber and call for further studies that may uncover its potential in production areas against different phytopathogens.A 5-year-old girl presented with treatment-refractory dry eye and recurrent episodes of eye pain. She had been previously diagnosed with syndromic congenital sodium diarrhea (SCSD) caused by a pathogenic variant in SPINT2. Her local pediatric ophthalmologist had made the diagnosis of severe dry eye with corneal erosions, based on which, we arranged an eye exam under anesthesia (EUA) and punctal plug placement. Anterior segment optical coherence tomography (OCT) and corneal photographs were taken during the procedure. There are reports describing similar ophthalmic findings in this syndrome. However, to the best of our knowledge, this is the first case report to document OCT imaging and corneal photographs in a patient with SCSD, which we feel expands the ophthalmic phenotype of this rare genetic disorder.Compared with conventional aqueous and ionic liquid electrolytes, deep eutectic solvent (DES) are considered as electrolyte for redox flow batteries because they have a wider electrochemical window and relatively low price. In this study, CeIV /CeIII and ZnII /Zn redox couples are used as the positive and negative active materials, respectively, in an electrolyte consisting of choline chloride ethylene glycol (ethaline). The structure of CeIII in the positive electrolyte is inferred through spectrum detection. CeIV /CeIII and ZnII /Zn redox couples show a stable potential difference of 2.2 V (vs. Ag) through cyclic voltammetry. The charge and discharge performance of battery was tested at different current densities. In addition, battery performance was evaluated at different temperatures and concentrations of cerium in the electrolyte. Consequently, at a current density of 0.5 mA cm-2 at room temperature and using 1.0 m CeIII , the battery performance reaches the best coulombic efficiency of 84 %.