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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often described as focusing on practical aspects of study design which include the recruitment and consent process, as well as adherence and the use routinely available equipment.
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A pragmatic trial that uses various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is vital for a pragmatic trial to be reliable and lessen the chance of bias is also essential. However, too much heterogeneity can result in problems with the design of the trial.
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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. Usually, they are requested by practitioners and policymakers in order to inform their decisions. They can be used to determine the causal relationship between an intervention and its results. They should not, however, be used to replace the need for explanation studies.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials can replace explanatory tests or if they are a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm a physiological or clinical hypothesis, and pragmatic trials, which inform the practice and policy decisions. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool sought to define the characteristics of a pragmatic study which includes recruitment, design and delivery of the intervention, and monitoring.
There is https://telegra.ph/Responsible-For-A-Pragmatic-Slots-Free-Trial-Budget-12-Top-Notch-Ways-To-Spend-Your-Money-09-19 in the number of pragmatic trials that are published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs), yielded 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming more sensitive to the issue of pragmatics. It is important to note that the majority of these studies were conducted in primary care settings.