e., going from a low concentration of 1 ng ml-1 to a high concentration of 100 ng ml-1 and back down to 10 ng ml-1). This is reflected by a percentage change of cumulative sensor response by 10%, 20%, and 22%, respectively from baseline, for cortisol. Similarly for DHEA, the sensor shows sensitivity to rising and falling changes with percentage changes of 45%, 55%, and 56% for 1, 100, and 10 ng ml-1 biomarker concentrations. This sensitivity is crucial in order to develop the circadian profile for the user. Thus, the sensor offers a first time demonstration of the potential of a passive self-monitoring approach for managing circadian abnormalities and is a good platform for tracking chronobiology.Owing to their large surface area and high uptake capacity, metal-organic frameworks (MOFs) have attracted considerable attention as potential materials for gas storage, energy conversion, and electrocatalysis. Various strategies have recently been proposed to manipulate the MOF surface chemistry to facilitate exposure of the embedded metal centers at the crystal surface to allow more effective binding of target molecules to these active sites. Nevertheless, such strategies remain complex, often requiring strict control over the synthesis conditions to avoid blocking pore access, reduction in crystal quality, or even collapse of the entire crystal structure. In this work, we exploit the hydrodynamics and capillary resonance associated with acoustically-driven dynamically spreading and nebulizing thin films as a new method for ultrafast synthesis of swordlike Cu3(1,3,5-benzenetricarboxylate)n (Cu-BTC) MOFs with unique monoclinic crystal structures (P21/n) distinct to that obtained via conventional bulk solvothermal synthesis, with 'swordlike' morphologies whose lengths far exceed their thicknesses. Through pulse modulation and taking advantage of the rapid solvent evaporation associated with the high nebulisation rates, we are also able to control the thicknesses of these large aspect ratio (width and length with respect to the thickness) crystals by arresting their vertical growth, which, in turn, allows exposure of the metal active sites at the crystal surface. An upshot of such active site exposure on the crystal surface is the concomitant enhancement in the conductivity of the MOF, evident from the improvement in its current density by two orders of magnitude.Low dimensional scintillators have been successfully and widely applied in the radiation-detection community for home security, scientific research, and imaging. We have grown zero-dimensional Cs4PbBr6 materials with CsPbBr3 nanocrystals embedded by using a solution-growth method at low temperature. We have demonstrated the scintillation properties of these 0D nanoscintillators with high luminescence quantum efficiency for green light. In addition, we have successfully achieved pulse height spectra with this 0D perovskite material, which has been demonstrated with fast decay time ( less then 10 ns), high energy resolution (3.0 ± 0.1%, 59.5 keV from 241Am), high light yield (64 000 photons per MeV) and long term stability under various atmospheres (moisture, radiation). These results are much better than those of the most widely used commercial products such as NaI(Tl). It also demonstrates that this 0D all-inorganic material can be employed as a scintillator for ionization radiation applications such as X-ray imaging and spectroscopy applications.Tris(oxazolynylmethyl)amine TOAR (where R denotes the substituent groups on the fourth position of the oxazoline rings) complexes of nickel(ii) have been synthesized as catalyst precursors for alkane oxidation with meta-chloroperoxybenzoic acid (m-CPBA). The molecular structures of acetato, nitrato, meta-chlorobenzoato and chlorido complexes with TOAMe2 have been determined using X-ray crystallography. The bulkiness of the substituent groups R affects the coordination environment of the nickel(ii) centers, as has been demonstrated by comparison of the molecular structures of chlorido complexes with TOAMe2 and TOAtBu. The nickel(ii)-acetato complex with TOAMe2 is an efficient catalyst precursor compared with the tris(pyridylmethyl)amine (TPA) analogue. Oxazolynyl donors' strong σ-electron donating ability will enhance the catalytic activity. Catalytic reaction rates and substrate oxidizing position selectivity are controlled by the structural properties of the R of TOAR. Reaction of the acetato complex with TOAMe2 and m-CPBA yields the corresponding acylperoxido species, which can be detected using spectroscopy. Kinetic studies of the decay process of the acylperoxido species suggest that the acylperoxido species is a precursor of an active species for alkane oxidation.Herein, a novel label-free photoelectrochemical (PEC) sensing platform with near-zero background noise was developed for M.SssI CpG methyltransferase (M.SssI MTase) activity assay based on a new Schottky junction of Bi2S3/Ti3C2 nanosheets. The proposed PEC sensor exhibited a low detection limit and a high signal-to-noise ratio for M.SssI MTase assay.Near-infrared (NIR) light-responsive nanoparticles of organic small-molecule dyes hold great promise as phototherapeutic dyes (PDs) for clinical translation due to their intrinsic merits, including well-defined structure, high purity, and good reproducibility. However, they have been explored with limited success in the development of photostable NIR PDs with extraordinary photoconversion for highly effective phototherapy. Herein, we have described amphiphilic BODIPY dye aggregates within the polymeric micelles (Micelles) as potent bifunctional PDs for dually cooperative phototherapy under NIR irradiation. Micelles possessed an intensive NIR absorption, high photostability, and favorable non-radiative transition, thereby exhibiting both remarkable singlet oxygen generation and photothermal effect under NIR light irradiation. Besides, Micelles had preferable cellular uptake, effective cytoplasmic drug translocation as well as enhanced tumor accumulation. Owing to the combined virtues, Micelles showed clinical potential as bifunctional PDs for photo-induced cancer therapy. This work thus provides a facile strategy to exploit advanced PDs for practical phototherapeutic applications.Owing to their environmentally friendly characteristic, InP-based quantum dots (QDs) show great potential in various fields as an alternative to Cd-based QDs. However, the current mainstream synthesis process, the (TMS)3P-based injection method, still faces many challenges, such as the high cost of (TMS)3P and complex temperature control. In contrast, the solvothermal method is considered to be more feasible and reproducible. Despite its potential advantages, little has been done to understand how the precursors influence the synthesis of InP QDs using the solvothermal method. In this research, InZnP/ZnS QDs were synthesized using practical phosphorus precursors (DEA)3P or (DMA)3P. Through the feasible regulation of zinc, indium, phosphorus and sulfur precursors, the band gap of the QDs could be widely and accurately tuned, and a much wider photoluminescence wavelength ranging from 484 nm to 651 nm could be achieved. Furthermore, InI3 and InBr3 contributed to the blueshift in the PL wavelengths, and the combination of (DEA)3P, (DMA)3P, n-DDT and t-DDT refined the PL wavelength with a small tuning gap of 5 nm.An original, facile and highly efficient method for the in situ generation of cyclic enolate-iminium 1,4-dipoles via unique thermal decomposition of easily available dipyrazolodioxadiazocines has been developed. Various substituted pyrazolo[5,1-d][1,3,5]dioxazines have been prepared in high yields via unusual cycloconversion of dipyrazolodioxadiazocines in the presence of ketones. Furthermore, the developed method is 100% atom economical and proceeds under metal-, catalyst- and solvent-free conditions.Extended X-ray absorption fine structure (EXAFS) is a powerful tool to determine the local structure in Pt nanoparticles (NP) on carbon supports, active catalysts for fuel cells. Highly oriented pyrolytic graphite (HOPG) covered with Pt NP gives samples with flat surfaces that allow application of surface science techniques. However, the low concentration of Pt makes it difficult to obtain good quality EXAFS data. We have performed in situ highly sensitive BCLA-empowered Back Illuminated EXAFS (BCLA + BI-EXAFS) measurements on Pt alloy nanoparticles. We obtained high quality Pt L3-edge data. We have devised a novel analytical method (model building analysis) to determine the structure of multi-component nanoparticles from just a single absorption edge. https://www.selleckchem.com/products/mhy1485.html The generation of large numbers of structural models and their comparison with EXAFS fits allows us to determine the structures of Pt-containing nanoparticles, catalysts for the oxygen reduction reaction. Our results show that PtCo, PtCoN and AuPtCoN form a Pt-shell during electrochemical dealloying and that the ORR activity is directly proportional to the Pt-Pt bond length.New easily functionalisable and highly fluorescent BOPAHY chromophores are synthesised via a one-pot two-step reaction starting from commercially available pyrrole-2-carbaldehydes and respective acyl hydrazides in the presence of BF3·OEt2. Most importantly, all BOPAHY dyes show excellent photophysical properties with quantum yields up to 0.92. Steady-state spectroscopy and quantum chemical calculations provide a first insight into these promising properties.Flexible and free-standing polymeric fibers, coupled with metal nanoparticles, present an excellent opportunity for highly sensitive surface-enhanced Raman scattering (SERS) spectroscopy-based detection platforms. Such host matrices are prepared by only a few preferred methods, followed by induction of metal nanoparticle aggregation in a protected environment to afford functional SERS platforms. We provide an interesting advance in this area by choosing a thiol-modified purine (L)-polymer blend, obtained through the electrospinning process, for directed decoration with gold nanoparticles. The described SERS purine-nanomat substrate enables the detection of uric acid, an important indicator of gout, preeclampsia, cardiovascular and kidney diseases, in aqueous solution up to 100 nM, with good stability and high sensitivity, offering superiority over existing techniques in terms of sensitivity and cost-effectiveness.In this work, we show how and why the interactions between charged cubic colloids range from radially isotropic to strongly directionally anisotropic, depending on tuneable factors. Using molecular dynamics simulations, we illustrate the effects of typical solvents to complement experimental investigations of cube assembly. We find that in low-salinity water solutions, where cube self-assembly is observed, the colloidal shape anisotropy leads to the strongest attraction along the corner-to-corner line, followed by edge-to-edge, with a face-to-face configuration of the cubes only becoming energetically favorable after the colloids have collapsed into the van der Waals attraction minimum. Analysing the potential of mean force between colloids with varied cubicity, we identify the origin of the asymmetric microstructures seen in experiment.