Background The present experiments evaluated the effects of acute high-intensity resistance exercise on episodic memory. Methods Two experiments were conducted. For Experiment 1, participants (N = 40; Mage = 21.0 years) were randomized into one of two groups, including an experimental exercise group and a control group (seated for 20 min). The experimental group engaged in an acute bout of resistance exercises (circuit style exercises) for 15 minutes, followed by a 5-min recovery period. Memory function was subsequently assessed using a multiple trial (immediate and delay), word-list episodic memory task (Rey Auditory Verbal Learning Test, RAVLT), and then followed by a comprehensive, computerized assessment of episodic memory (Treasure Hunt task, THT). The THT involved a spatio-temporal assessment of what, where, and when components of episodic memory. Experiment 2 evaluated if altering the recovery period would influence the potential negative effects of high-intensity resistance exercise on episodic memoryxercise recovery period (e.g., 5-min) is employed, but with a longer recovery period (10+ min), acute high-intensity resistance exercise may, potentially, enhance episodic memory. © 2020 Journal of Lifestyle Medicine.According to the studies, physical exercise can prove to be a viable tool for the treatment of depressed patients. In the present review, various research studies from the year 2017-2019 were analyzed. https://www.selleckchem.com/products/msdc-0160.html Various reviews also confirmed that exercise played important role in the treatment of depression. After study, it was confirmed that structured and adherence to the exercise played an important role in the success of exercise protocol towards the treatment of patients. Conventional methods such as pharmacotherapy and psychotherapy were also discussed. It was also studied that sedentary behavior of patients with mental disorder can affect the patient badly. Therefore, all the studies concluded that exercise can be considered as better tool for the treatment of depressed patients if exercise are structured and protocol are regularly performed. © 2020 Journal of Lifestyle Medicine.Countries blessed with natural resources have generally struggled to achieve sustainable economic development and prosperity. Population growth, the depletion of natural resources coupled with mismanagement, and sharp fluctuations in prices of those resources are among the main reasons for sub-optimal economic performance. Some resource-rich countries have been expending effort and money in an attempt to change this inverse relationship (a.k.a. "the resource curse") by designing policies to diversify their economies with high value-added industries and sectors. Qatar is a such country and point of the interest in this article. Qatar's political and economic structure, its efforts to diversify its economy, and the potential for improved entrepreneurial outcomes with high value-added products, services, businesses, and industries are analyzed. The country has been very effective in maximizing the benefits of its oil resources and especially its large natural gas reserves, becoming the largest exporter of liquefied natural gas (LNG) in the world. Revenues from oil and gas sales have been invested in the domestic economy and global assets. Thus far, however, it has not shown the in-house capacity for innovation and entrepreneurship critical for sustainable economic diversification going forward. This publication was made possible in part by NPRP grant #10-1203-160007 from the Qatar National Research Fund (a member of the Qatar Foundation). © 2020 Published by Elsevier Ltd.Background Migration is a challenging life transition that may be a source of various problems related to well-being and mental health. However, the psychological adaptation of migrants may be potentially facilitated by social self-efficacy-the beliefs in one's ability to initiate and maintain interpersonal relationships. Previous research suggests that social self-efficacy is positively related to adjustment and negatively related to loneliness, depression, and psychological distress. Research also confirms that self-efficacy beliefs can be effectively enhanced using Internet-based interventions. These results served as a background for creating the New in Town, a self-help Internet-based intervention for internal migrants in Poland that aims at increasing social self-efficacy. Exercises in the intervention are based on the principles of Cognitive Behavioral Therapy and relate to sources of self-efficacy beliefs mastery experiences, vicarious experiences, verbal persuasions, and emotional and physiological scould provide an easily accessible support option for internal migrants in Poland. Trial registration The trial was registered with ClinicalTrials.gov (identifier NCT04088487) on 11th September 2019. © 2020 The Authors. Published by Elsevier B.V.Rational Many efforts have been made to develop ligand-directed nanotheranostics in cancer management which could afford both therapeutic and diagnostic functions as well as tumor-tailored targeting. Theranostic nanoplatform targeting transferrin receptor (TfR) is an effective system for favorable delivery of diagnostic and therapeutic agents to malignancy site. Methods To enable amalgamation of therapy and diagnosis to many TfR+ tumor, hTfR (human TfR) monoclonal antibody (mAb)-functionalized HPPS nanoparticle (HPPS-mAb) was prepared with hTfR mAb on the shell and with fluorophore DiR-BOA in the core. The targeting specificity was investigated in vitro by immunostaining and in vivo using a double-tumor-engrafted mouse model. HPPS-mAb/siRNA effect on HepG2 cells was determined by RT-PCR and western blot. Results HPPS-mAb could specifically target cancer cells through TfR and achieve tumor accumulation at an early valuable time node, thus efficiently delivering therapeutic survivin siRNA into TfR+ HepG2 cells and mediating cell apoptosis. DiR-BOA can act as an imaging tool to diagnose cancer. Conclusions Our studies provide a promising TfR mAb-directed theranostic nanoplatform candidate in tumor molecular imaging and in TfR targeted tumor therapy. © The author(s).