Descriptive analysis of the representativeness of recruited participants and completeness of survey responses will be conducted. RESULTS Participant recruitment was completed in October 2018, and data collection for the baseline and follow-up surveys was completed in November 2019. As of April 2020, the process of acquiring health records from administrative data collections has commenced. CONCLUSIONS The findings from this pilot study will identify areas for improvement and inform the development of a future longitudinal cohort study of emerging adults. TRIAL REGISTRATION Australian New Zealand Clinical Trials Registry ACTRN12618001364268; https//tinyurl.com/teec8wh. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID) DERR1-10.2196/16108. ©Reidar P Lystad, Diana Fajardo Pulido, Lorna Peters, Melissa Johnstone, Louise A Ellis, Jeffrey Braithwaite, Viviana Wuthrich, Janaki Amin, Cate M Cameron, Rebecca J Mitchell. Originally published in JMIR Research Protocols (http//www.researchprotocols.org), 23.04.2020.BACKGROUND There is a lack of research on the effectiveness of online peer support groups for reducing social isolation and depressive symptoms among caregivers, and previous research has mixed results. OBJECTIVE This study aimed to test whether military caregivers who joined a new online peer support community or engaged with an existing online community experienced decreased perceived social isolation and improved depressive symptoms over 6 months. METHODS We conducted a longitudinal study of 212 military caregivers who had newly joined an online community and those who were members of other military caregiver groups. Multiple indicators of perceived social isolation and depressive symptoms were assessed at baseline and at 3 and 6 months. RESULTS Compared with caregivers in the comparison group, caregivers who joined the new group experienced less perceived social isolation at 3 months (eg, number of caregivers in social network [unstandardized regression coefficients] b=0.49, SE 0.19, 95% CI 0.87 to 0.02), but this effect did not persist at 6 months. Those who engaged more with new or existing groups experienced less perceived social isolation over time (eg, number of caregivers in social network b=0.18, SE 0.06, 95% CI 0.02 to 0.27), and this relationship was mediated by increased interactions with other military caregivers (95% CI 0.0046 to 0.0961). Engagement with an online group was not associated with improvements in depressive symptoms. CONCLUSIONS Online communities might help reduce social isolation when members engage with the group, but more intensive treatment is needed to improve depressive symptoms. ©Thomas E Trail, Esther Friedman, Carolyn M Rutter, Terri Tanielian. Originally published in the Journal of Medical Internet Research (http//www.jmir.org), 23.04.2020.BACKGROUND Problematic internet use (PIU) is associated with mental health concerns such as depression and affects more than 12% of young adults. Few studies have explored potential influences of parent-college student digital communication on college students' risk of PIU. OBJECTIVE This study sought to understand the relationship between parent-college student digital communication frequency via phone calls, text messages, and Facebook contacts and PIU among college students. METHODS Incoming first-year students were randomly selected from registrar lists of a midwestern and northwestern university for a 5-year longitudinal study. Data from interviews conducted in summer 2014 were used. Measures included participants' daily Facebook visits, communication frequency with parents via phone call and text message, and 3 variables related to Facebook connection status and communication (1) parent-college student Facebook friendship status, (2) college student blocking personal Facebook content from parent, and (3 Facebook visits were positively associated with increased PIU risk (b=0.04, P=.006) and being friends with a parent on Facebook was negatively associated with PIU risk (b=-0.66, P=.008). Participant daily Facebook visits were not a significant mediator of the relationship between college student-parent Facebook friendship and PIU risk (b=-0.04; 95% CI -0.11 to 0.04). CONCLUSIONS This study did not find support for a relationship between parent-college student digital communication frequency and PIU among college students. Instead, results suggested Facebook friendship may be a protective factor. Future studies should examine how a parent-child Facebook friendship might protect against PIU among children at varying developmental stages. ©Bradley Kerr, Jon D D'Angelo, Ali Diaz-Caballero, Megan A Moreno. Originally published in JMIR Pediatrics and Parenting (http//pediatrics.jmir.org), 23.04.2020.BACKGROUND Although some neuropsychological (NP) tests are considered more central for the diagnosis of Alzheimer disease (AD), there is a lack of understanding about the interaction between different cognitive tests. OBJECTIVE This study aimed to demonstrate a global view of hierarchical probabilistic dependencies between NP tests and the likelihood of cognitive impairment to assist physicians in recognizing AD precursors. METHODS Our study included 2091 participants from the Framingham Heart Study. These participants had undergone a variety of NP tests, including Wechsler Memory Scale, Wechsler Adult Intelligence Scale, and Boston Naming Test. Heterogeneous cognitive Bayesian networks were developed to understand the relationship between NP tests and the cognitive status. The performance of probabilistic inference was evaluated by the 10-fold cross validation. RESULTS A total of 4512 NP tests were used to build the Bayesian network for the dementia diagnosis. The network demonstrated conditional dependency between different cognitive functions that precede the development of dementia. The prediction model reached an accuracy of 82.24%, with sensitivity of 63.98% and specificity of 92.74%. https://www.selleckchem.com/products/sbi-0206965.html This probabilistic diagnostic system can also be applied to participants that exhibit more heterogeneous profiles or with missing responses for some NP tests. CONCLUSIONS We developed a probabilistic dependency network for AD diagnosis from 11 NP tests. Our study revealed important psychological functional segregations and precursor evidence of AD development and heterogeneity. ©Huitong Ding, Ning An, Rhoda Au, Sherral Devine, Sanford H Auerbach, Joseph Massaro, Prajakta Joshi, Xue Liu, Yulin Liu, Elizabeth Mahon, Ting FA Ang, Honghuang Lin. Originally published in the Journal of Medical Internet Research (http//www.jmir.org), 23.04.2020.