Languages evolve as an effect of communal competition while environmental and social dynamics characterize a language. There are thousands of languages spoken around the world but many of them are in danger of going extinct because of language competition and shifts. Modeling language preservation is important because the rise and fall of a language directly impacts the culture attached to it. We present a study of language competition and preservation between a bilingual population and two monolingual populations using a mathematical model involving nonlinear systems of differential equations. Building upon the ideas of previous models in the literature, the model utilizes population proportions with a simple structure that yields noteworthy behavior including a stable spiral with all three language groups preserved. We investigate how bilinguals and monolinguals can coexist as well as how they can affect one another. Los idiomas evolucionan como efecto de la competencia comunitaria, mientras que las dinámicas ambientales y sociales caracterizan a un idioma. Se hablan miles de idiomas en todo el mundo, pero muchos de ellos están en peligro de extinción debido a la competencia lingüística y los cambios. Modelar la preservación del lenguaje es importante porque el auge y la caída de un idioma impacta directamente en la cultura que se le atribuye. Presentamos un estudio de la competencia y preservación del lenguaje entre una población bilingüe y dos poblaciones monolingües utilizando un modelo matemático que involucra sistemas no lineales de ecuaciones diferenciales. Sobre la base de las ideas de modelos anteriores en la literatura, el modelo utiliza proporciones de población con una estructura simple que produce un comportamiento notable que incluye una espiral estable con los tres grupos lingüísticos preservados. Investigamos cómo los bilingües y los monolingües pueden coexistir y cómo pueden afectarse unos a otros.
For irradiation of localized prostate-cancer, moderately-hypofractionated regimens with a variety of dose per fraction are used. We adopted a regimen of 70Gy in 28 fractions of 2.5Gy, using state of the art radiotherapy (RT) and closely monitored the efficacy, toxicity and health-related quality of life (HRQoL) in a large cohort, using patient-reported outcomes.

Between 2008 and 2016, 462 patients with intermediate- to high-risk localized prostate cancer were treated with RT, 28 fractions of 2.5Gy, using IMRT/VMAT, an online fiducial-maker based correction protocol and a daily inserted endorectal balloon. Overall freedom from failure (no biochemical or clinical recurrence) , as well as self-reported genitourinary (GU) and gastrointestinal (GI) related toxicity and HRQoL are reported.

Overall freedom from failure rates at 3 and 5years were 92.0% (89.1-94.9%) and 83.5% (78.6-88.4%), respectively. Prevalence rates of grade≥2 GU/GI-toxicity were 16.3%/6.3% and 22,1%/3.2% after 3 and 5years respectively. There essential for a good comparison between different studies. Finally, prevalence rates show a better correlation with HRQoL than actuarial incidence rates do and might therefore better represent the burden of toxicity.
Most studies report post-mastectomy local recurrences as chest wall recurrences without clarifying whether the recurrence is in the subcutaneous tissue, muscle or underlying rib. Post-mastectomy chest wall radiation is recommended in patients at increased risk of locoregional recurrence. Chest wall radiation-related fibrosis has become an important clinical consideration in the era of immediate implant-based breast reconstruction. In patients with commonly performed subpectoral implant-based reconstruction, the pectoralis major becomes relocated anterior to the implant and just deep to skin, therefore raising the question of value in radiating deep chest wall structures. This study assessed the rate of recurrence in each anatomical region of chest wall in post-mastectomy patients.

A comprehensive breast cancer database of 4287 patients at a single regional cancer center from 2006 to 2018 was retrospectively analyzed to identify 1571 mastectomy patients. Recurrences were classified as local skin/subcutaneoriate to reduce radiation-associated toxicity since avoiding circumferential radiation of an implant may prevent capsular contracture without compromising treatment benefit.Droplet interface bilayers (DIBs) are model membranes formed between lipid monolayer-encased water droplets in oil. Compared to conventional methods, one of the most unique properties of DIBs is that they can be connected together to generate multi-layered 'tissue-like' networks, however introducing communication pathways between these compartments typically relies on water-soluble pores that are unable to gate. Here, we show that network connectivity can instead be achieved using a water-insoluble membrane protein by successfully reconstituting a chemically activatable mutant of the mechanosensitive channel MscL into a network of DIBs. Moreover, we also show how the small molecule activator can diffuse through an open channel and across the neighbouring droplet to activate MscL present in an adjacent bilayer. This demonstration of membrane protein mediated bilayer communication could prove key toward developing the next generation of responsive bilayer networks capable of defining information flow inside a minimal tissue.
Migration of Venezuelan citizens to other South American countries has increased in recent years. While the prevalence, morbidity, and mortality of infectious diseases in Venezuelan migrants across South America appears to be well described, the non-communicable disease (NCD) and maternal and child health needs in this population is less clear. A scoping review of existing peer-reviewed primary research and grey literature describing the epidemiology of NCDs and maternal and child health needs in Venezuelan migrants in major South American host countries was performed in order to highlight important gaps in knowledge.

A scoping review was performed of peer-reviewed research and grey literature for NCD and maternal and child health needs among Venezuelan migrants living in the following host South American countries with greater than 100,000 migrants Argentina, Brazil, Chile, Colombia, Ecuador, and Peru. https://www.selleckchem.com/products/arq531.html A total of 47 electronic databases were searched for primary research published between 2017 and 2020 in either English or Spanish.