RESULTS IIR caused severe lung damage, including morphological changes, high permeability, airway resistance, low static compliance, hypoxemia, and acidemia. Pulmonary and plasma MDA content and MPO activity increased, whereas SOD activity decreased. The HMGB1/TLR4/PKR signaling pathway was activated following IIR. Pretreatment with propofol markedly attenuated lung injury (such as reducing the lung edema and permeability), increased MDA content and MPO activity, and restored SOD activity induced by IIR, accompanied by inhibiting the effect of the HMGB1/TLR4/PKR signaling pathway. CONCLUSIONS IIR caused acute lung injury in pigs. Pretreatment with propofol alleviated the lung injury, which was related to its suppression of the HMGB1/TLR4/PKR signaling pathway.Why do we react emotionally to music? Does music appreciation have an adaptive value? What is the role of music in spiritual and healing practices? Music is a fascinating area of research for evolutionary theory, psychological development, and emotional perception and elicitation. https://www.selleckchem.com/products/oxidopamine-hydrobromide.html It is a highly valued feature of all known living cultures and societies, pervading many aspects of daily and devotional life and playing many roles. The question that still lingers among music researchers however is why is this so. This paper will discuss the influence of music on our emotional life, psychological wellbeing, spiritual practices and finally on physiological processes present in our body. The aim is to examine the origin of our relationship to music through the mentioned perspectives and to attempt to link the various theoretical perspectives on this subject across two major domains; health and spirituality.Societal importance and the quality of scientific research highly depend on the usefulness of the results of research for the societal and scientific community. The wish to allocate the funds to high-quali-ty research and to establish right criteria for scientific evaluation and academic career progression, make scientific criteria increasingly important to measure the quality of research and knowledge valorization. However, it is very difficult to apply the right criteria which can objectively assess scientific research. For many years, there has been a great interest in scientific ranking and evaluation of scientific journals, but also of sci-entific contribution of scientists. It is generally accepted that the IF (WoS) and the total number of citations of articles published in the journal, are the most relevant parameters of the journal's significance. However, the significance of a scientist and the value of their scientific production are much more complicated to evaluate and they cannot be directly reflected by the importance of the journals in which their articles are published. In this article, the authors describe and evaluate the most known scientific databases which are used in science. The majority of existing science metric systems, which evaluate the achievement of scientists are focused solely on the number of citations of their articles. For example, H-index, which is calculated as the lowest ranked ar-ticle which number of citations matches its ranking number, has considerable shortcoming because it does not take into account the individual contribution of each author and allows expanding author lists with authors whose contribution may be insignificant or none. Therefore, the authors propose Z-score, as a new science met-ric system, which takes into account the author's contribution to the scientific article and greatly remedy major discrepancies in evaluating scientific production of individual authors and institutions.Bosnia and Herzegovina has generally opted to join the European Union. Preliminary decisions have already been taken, but BiH needs to meet some of the standards/criteria contained in the 14 recom-mendations made by the European Commission before formal negotiations with the EU begin. One of the important assumptions of a successful path to the EU is that BiH accelerates economic development and modernizes the economic structure as a whole. In this regard, it is especially important that BiH advances technological development, improves its environmental policy and accelerates the energy transition. The text analysed the current development level of these areas and suggested some measures that should improve the current unsatisfactory situation in them. Particular attention was paid to measures to increase innovation capacity, the need for more vigorous inter-ventions in solving environmental problems and the energy transition as a precondition for entry into Industry 4.0, the introduction of the green economy and the acceptance of decarbonisation as long-term policies. It was stressed that these are the ultimate targets by 2050, in agreement with the long-term development orientation of the European Union.The COVID-19 pandemic (SARS-CoV-2) has caused multiple consequences globally, and all can be re-searched and addressed multidisciplinary, ie from a health (medical), legal, economic and security aspect. In this paper, the author focuses on the legal, ie criminal law aspect of this pandemic. After more than a year of the COVID-19 pandemic in the world, based on the measures taken in almost all countries, it can be concluded that the health and legal aspects are primary and complementary. This claim is supported by the fact that the protection of human health must be regulated by adequate legislation, which is, above all, the Law on the Protection of the Population from Infectious Diseases. However, in such an emergency situation without criminal protection, it is difficult to achieve effective health care for the population.Therefore, this article analyzes the criminal and medical aspects of crimes against human health that are similar or almost identical in all countries in the region, such as Bosnia and Herzegovina, Croatia, Slovenia, Serbia, Northern Macedonia and Kosovo.The article is a review of key ideas and proposals from the book "EmpowerUs From Crisis to Strategic Harmony" (Kitsap Publishing, 2020). In the preface to the book Philip Kotler, the Father of modern marketing and one of the most influential global management experts points out that there are many "fixing the world books, and this is one of the best". The authors are Ira Kaufman, a transformation strategist and consultant from the USA, and Velimir Srića, a leadership consultant and professor of management informa-tion systems from Croatia. Both are well known experts on management of change, digital transformation, and leadership development. The article provides an overview of the Strategic Harmony model and its application. After explaining the key issues of "the broken world", the text focuses on proposed solutions. First, it describes the Change Drivers and their role in initiating necessary transformation. Then, it discusses the importance of mindset change, based on so called TEST values (Trust, Empathy, Sustainability, and Transparency).