Organisms respond to mitochondrial stress by activating multiple defense pathways including the mitochondrial unfolded protein response (UPRmt). However, how UPRmt regulators are orchestrated to transcriptionally activate stress responses remains largely unknown. Here we identified CBP-1, the worm ortholog of the mammalian acetyltransferases CBP/p300, as an essential regulator of the UPRmt, as well as mitochondrial stress-induced immune response, reduction of amyloid-β aggregation and lifespan extension in Caenorhabditis elegans. Mechanistically, CBP-1 acts downstream of histone demethylases, JMJD-1.2/JMJD-3.1, and upstream of UPRmt transcription factors including ATFS-1, to systematically induce a broad spectrum of UPRmt genes and execute multiple beneficial functions. In mouse and human populations, transcript levels of CBP/p300 positively correlate with UPRmt transcripts and longevity. Furthermore, CBP/p300 inhibition disrupts, while forced expression of p300 is sufficient to activate, the UPRmt in mammalian cells. These results highlight an evolutionarily conserved mechanism that determines mitochondrial stress response, and promotes health and longevity through CBP/p300.Insecure attachment and borderline personality disorder (BPD) are defined by similar affective and interpersonal processes. Individuals diagnosed with BPD, however, represent only a subset of those described as insecurely attached, suggesting that attachment may hold broader relevance for socio-affective functioning. Based on a 21-day ecological momentary assessment protocol in a mixed clinical and community sample (N = 207) oversampled for BPD, we evaluate the discriminant validity of each construct as it influences daily interpersonal interactions. We find that insecure attachment is associated with elevated perceptions of interpersonal disaffiliation and maladaptive strategies for affect regulation, whereas enacted interpersonal hostility is more distinctive for BPD. In a series of sensitivity analyses, we further highlight potential caveats to these findings when studying both constructs concurrently. Together, our results suggest that both insecure attachment and BPD contribute to problematic affective and interpersonal processes, but that they do so at different stages of the unfolding social interaction, which has important implications for their maintenance and treatment.An inhomogeneous anisotropic physical model of the brain cortex is presented that predicts the emergence of non-evanescent (weakly damped) wave-like modes propagating in the thin cortex layers transverse to both the mean neural fiber direction and to the cortex spatial gradient. Although the amplitude of these modes stays below the typically observed axon spiking potential, the lifetime of these modes may significantly exceed the spiking potential inverse decay constant. Full brain numerical simulations based on parameters extracted from diffusion and structural MRI confirm the existence and extended duration of these wave modes. Contrary to the standard paradigm that the neural fibers determine the pathways for signal propagation in the brain, the signal propagation due to the cortex wave modes in highly folded areas will exhibit no apparent correlation with the fiber directions. The results are consistent with numerous recent experimental animal and human brain studies demonstrating the existence of electroicular for neuroimaging methods that detect electromagnetic physiological activity, such as EEG and MEG, and in general for the understanding of brain activity, including mechanisms of memory.This study aimed to assess the status of national diabetes associations in the Pacific Island Countries and Territories as a starting point for strengthening their development and effectiveness in the prevention and control of diabetes. This cross-sectional study was conducted in 21 Pacific Island Countries and Territories using a structured questionnaire that gathered information from national non-communicable diseases prevention and control focal persons on diabetes associations, organizational structure, funding sources, and ongoing activities to address diabetes. The overall status of national diabetes associations was assessed using standardized criteria. Of the 21 countries surveyed, 18 (86%) responded. Of these, 12 (67%; American Samoa, Northern Mariana Islands, Federated States of Micronesia, French Polynesia, Fiji, Guam, Nauru, Papua New Guinea, Marshall Islands, Solomon Islands, Tonga, and Vanuatu) have a national diabetes association. Half of the existing associations are fully functioning, while the remainder is either partially functioning or not functioning. Only 50% of existing associations have a regular funding source, and many lack clear visions and workable governance structures. https://www.selleckchem.com/products/at13387.html This study fills a knowledge gap on the current status of associations and forms a baseline from which associations can be strengthened. It also draws attention to the need for Pacific leaders to invest and engage more in civil societies for better and effective diabetes care for all.in the State of Hawai'i, and the shortage is expected to worsen in the coming years. During the 2015-2016 academic year, a 6-month Primary Care Mentorship Program (PCMP) for first-year medical students was launched at the John A. Burns School of Medicine (JABSOM). This study sought to determine (1) whether participation in a PCMP as a first-year medical student correlates with an increased likelihood of matching into a primary care graduate medical education (GME) residency specialty, (2) whether the PCMP medical student participants developed lasting mentorship relationships with their assigned mentor, and (3) whether a PCMP is a worthwhile endeavor for medical schools to incorporate into their structured undergraduate medical education curriculum. Mentees were surveyed before and after the PCMP and after the residency Match. Overall, 105 (36%) of the 288 students in the JABSOM classes of 2019-2022 have applied to participate in the PCMP. Seventeen (85%) of the 20 JABSOM class of 2019 PCMP mentees completed the post-Match reflection survey. The study found as follows (1) participation in a 6-month PCMP as a first-year medical student does not correlate with an increased likelihood of matching into a primary care GME residency specialty, (2) 7 (41%) participants did continue their mentorship relationship following completion of the PCMP, and (3) overwhelmingly positive qualitative feedback from mentees and the number of mentees who did establish lasting mentorship relationships suggest a PCMP is a worthwhile endeavor for medical schools to implement.