es leading to treatment optimisation and ensuring desired treatment outcomes.
The present study showed that polypharmacy is prevalent among patients in Jordan. While polypharmacy was not affected by smoking status, gender, BMI and educational level, it was significantly affected by monthly income and age. Further plans should be put in place to reduce polypharmacy, starting with effective pharmaceutical care services leading to treatment optimisation and ensuring desired treatment outcomes.
Dental educators play crucial roles in dental education and in the functioning of dental schools. Whilst it is recognised that dental educators need more than relevant disciplinary expertise and that scholarly development of dental educators is important, there is a lack of knowledge about ways research can be used to promote professional development. This article aims to showcase a research methodology for professional inquiry that is widely used in teacher education to promote the view that dental education is a professional practice.
Self-study methodology was employed by four dental educators to illuminate their theory-informed practice. We chose to frame the inquiry around technology and accumulated three forms of data individual journaling, video-call discussions and Padlet/bricolage. Analysis of this data focused on how the learning was co-constructed by the group.
Five key elements of our self-study were constructed into narratives understanding technology as a dental educator, being a learner and embodied scholarship, the (expanded) roles of a teacher in a technological environment, advancing our own professional identity as an educator, and possibilities and limits for self-study in the dental education context.
Professionalisation of dental educators is critical to sustainable dental education. By educators researching their own practice, research approaches such as self-study can perform a dual role of facilitating scholarly development and contributing to the generation of new knowledge about becoming and being a dental educator.
Professionalisation of dental educators is critical to sustainable dental education. By educators researching their own practice, research approaches such as self-study can perform a dual role of facilitating scholarly development and contributing to the generation of new knowledge about becoming and being a dental educator.Many critically endangered plant species exist in small, genetically depauperate or inbred populations, making assisted gene flow interventions necessary for long-term population viability. However, before such interventions are implemented, conservation practitioners must consider the genetic and demographic status of extant populations, which are strongly affected by species' life-history traits. In northwestern Europe, Juniperus communis, a dioecious, wind-pollinated and bird-dispersed gymnosperm, has been declining for the past century and largely exists in small, isolated and senescent populations. https://www.selleckchem.com/products/LBH-589.html To provide useful recommendations for a recovery plan involving translocation of plants, we investigated genetic diversity and structure of populations in Belgium using four microsatellite and five plastid single-nucleotide polymorphism (SNP) markers. We detected no clonality in the populations, suggesting predominantly sexual reproduction. Populations exhibited high genetic diversity (He = 0.367-0.563) and low to moderate genetic differentiation (FST ≤ 0.133), with no clear geographic structure. Highly positive inbreeding coefficients (FIS = 0.221-0.507) were explained by null alleles, population substructuring and biparental inbreeding. No isolation by distance was observed among distant populations, but isolation at close geographic proximity was found. Patterns were consistent with high historical gene flow through pollen and seed dispersal at both short and long distances. We also tested four pre-germination treatments among populations to improve germination rates; however, germination rates remained low and only cold-stratification treatments induced germination in some populations. To bolster population regeneration, introductions of cuttings from several source populations are recommended, in combination with in situ management practices that improve seedling survival and with ex situ propagation.Regioselective transformation is among the long-standing challenges in organic synthesis. In this communication, a copper-catalyzed selectivity controlled regiodivergent borocarbonylation of imines with alkyl iodides has been developed. Various α-amino ketones and α-boryl amides were produced in moderate to good yields from the same substrates. The choice of the ligand is key for the regioselectivity control α-amino ketones were produced selectively in good yields with (p-CF3 C6 H4 )3 P as the ligand, whereas the corresponding α-boryl amides were obtained with high regioselectivities when using Me IMes as the ligand.
Acquired resistance to drug involves multilayered genetic and epigenetic regulation. Inhibition of EZH2 has proven to reverse the tamoxifen resistance back to the sensitive state in breast cancer. However, the molecular players involved in EZH2-mediated effects on tamoxifen-resistant MCF-7 cells are unknown. This study was conducted to understand the global change in proteome profile of tamoxifen-resistant MCF-7 breast cancer cells upon EZH2 knockdown.
Tamoxifen resistance MCF-7 breast cancer cells were established using increasing concentrations of 4-hydroxy tamoxifen. Using label free proteomics approach, we studied the alteration in total proteome in resistant cells as well as cells transfected with siEZH2 in comparison to sensitive and cells transfected with non-targeting siRNA.
Here, we report list of proteins that were previously not recognized for their role in tamoxifen resistance and hold a close association with breast cancer patient survival. Proteins Annexin A2, CD44, nucleosome assembly protein 1, and lamin A/C were among the most upregulated protein in tamoxifen-resistant cells that were found to be abrogated upon EZH2 knockdown. The study suggests the involvement for various proteins in acquiring resistance towards tamoxifen and anticipates further research for investigating their therapeutic potentials.
Overall, we propose that targeting EZH2 or the molecules down the cascade might be helpful in reacquiring sensitivity to tamoxifen in breast cancer.
Overall, we propose that targeting EZH2 or the molecules down the cascade might be helpful in reacquiring sensitivity to tamoxifen in breast cancer.