The results of the study allow us to conclude that in order to regulate the functional activity of lymphocytes during various diseases, it is necessary to take into account an autoregulatory mechanisms that ensure the interaction of immune cells with the mediators of the nervous and endocrine systems, maintaining the homeostasis of these systems and regulating the immune response.The aim of the study was to determine the influence of various drinking liquids on an the dentoalveolar system in rats. The study was carried out on 25 white male rats from the nursery of Krolinfo branch of the Moscow region which were kept in standard vivarium conditions. Age of rats-3-6 months, weight - 150-200 grams. The study was carried out in accordance with the ethical principles of humane treatment of animals, in accordance with the current legislation of the Russian Federation. To assess the effect of consumed fluids, groups of 5 animals of the same sex (males, females) were used. The animals were randomly assigned to groups. Observation of animals was carried out for 6 months, during this period the animals were in conditions of free access to food and as drink received the studied liquids ad libitum. Experimental groups within 3 months received the following types of drink I (control group) - tap water; The II group - Coca-Cola; The III group - honey water; The IV group - the distilled water; The V group - light water. The results obtained by the authors and the data provided in literature confirm that among the factors that affect the teeth condition, in particular the characteristics of the hardness of enamel and dentin, the use of various sugar-containing drinks, as well as the duration, quantity, and frequency of their use, can play a significant role. These factors remain largely unexplored at present. It is obvious that in order to stop caries, it is necessary to develop and carry out a set of preventive measures, including limiting the consumption of sweets and beverages containing sugar, along with regular dental care and a balanced diet.Objective - to find out the possibility of using molecular hydrogen in the correction of no-reflow syndrome in the polyuric stage of acute kidney injury 72 hours after the administration of mercuric chloride in rats on a hyposodium diet. The experiments were performed on 60 male white non-linear sexually mature rats weighing 0.16-0.18 kg to study the effect of water loading with saturation with molecular hydrogen. Sublimate nephropathy was modeled under conditions of a hyposodium diet by subcutaneous injection of 0.1% mercury dichloride solution at a dosage of 5 mg/kg with a study after 72 hours, which corresponded to the early polyuric stage of acute kidney injury and the development of no-reflow syndrome. To saturate the water with molecular hydrogen at a concentration of 1.2 ppm and a redox potential from -100 to -350 mV, a new generation H2 generator Blue Water 900 (Korea) was used, containing an improved proton-exchange membrane PEM/SPE. Used pathophysiological, biochemical, functional, chemiluminescent,rge and small vicious circles with an antioxidant solution of H2 was shown due to its high permeability and the ability to neutralize the hydroxyl radical and peroxynitrite.This study was aimed at investigating morphological and functional changes in the small intestine mucosal layer of mice with antibiotic-induced dysbiosis and following its correction with probiotics and enterosorbents. The study was carried out on BALB / c line white laboratory mice. Samples of the small intestine, liver, and spleen were taken to be processed for electron microscopy. To determine qualitative and quantitative composition of intestinal lumenal microbiome, animals' faeces were studied. Bacteria were isolated and identified by standard methods. This study has experimentally confirmed the ability of antibacterials to induce dysbiotic conditions in animals that are accompanied by significant shifts in the composition of normal microflora, manifested with cytodestructive disorders in the small intestinal epithelium. We have demonstrated the property of probiotics and, to a lesser extent, of sorbents to reduce the intensity and extension of cytodestructive disorders in the course of antibiotic-induced dysbiosis and to normalize the body immune responses that accompany the development of dysbiotic conditions.Apoptosis plays one of the major roles in the progression of human cancers including cervical carcinoma. The aim of our study was to analyse the expression of Cas3, Bax and their correlation with the proliferation index and ER expression status during the progression of cervical intraepithelial neoplasia (CIN). Study included altogether 140 specimens, divided into two major groups, such as cervical lesions without co-infections and with co-infections. https://www.selleckchem.com/products/cc-90011.html Standard immunohistochemistry was used to detect antigens Ki67, Cas3, Bax and ER. The study results showed that the expression of Cas3 is significantly decreased whilst the expression of Bax is significantly increased during the progression of CIN in both groups with and without co-infections. The expression of Bax negatively correlates with the expression of Cas3 (r=-42.4, p less then 0.05) and ER (r=-33.4, p less then 0.05) and positively correlates with the expression of proliferation marker Ki67 (r=56.3, p less then 0.05). The results indicate that the deregulated apoptosis measured as increased expression of Bax and Cas3 loss, as well as the increase in proliferation index measured as Ki67 expression is significantly related to the progression of CIN into cervical carcinoma. Therefore, the measuring of mentioned protein expression could be used as the markers of the CIN progression.The number of demyelinating diseases of central nervous system are prone to grow nowadays. The most socially significant and well studied one is multiple sclerosis. The search of susbstances that would stop demyelinisation or reinforce the process of remyelination is in great request. Thyreoid gland hormones play a sufficient role in nervous system functioning and developing. Some studies show, that triiodothyronine regulates myelin synthesis through thyroid-sensitive nuclear receptors. In our study process of demyelination were modelled via сuprizone model, which appears to be an optimal method, since it allows to witness the process of demyelination without an autoimmune component. Results of the study show effectiveness of thyroid hormones for myelin and axon protection. In rats, under the influence of cuprizone, behavioral reactions are inhibited and changes in the structures of neurons in the cerebral cortex and lumbar spinal cord are noted. The severity of these disorders also depends on the thyroid status of the rat organism.