In the world of contemporary music, few artists have managed to captivate audiences quite like Post Malone. With his unique blend of genres, infectious melodies, and laid-back charisma, he has become a household name. But beyond the chart-topping hits and viral moments lies a fascinating story of creativity, resilience, and authenticity that often goes unnoticed. This article aims to peel back the layers of the artist we thought we knew, revealing the captivating journey of Post Malone that showcases his genius in ways many of us might not have considered.

As we delve deeper into his life and artistry, we will explore the influences that shaped his eclectic music style, his rise to fame, and the personal experiences that fuel his creativity. There's more to this artist than catchy hooks and striking tattoos; Post Malone's narrative is one of innovation and cultural impact. Join us as we uncover the aspects of his personality and career that make Post Malone a trailblazer in the music industry, and perhaps inspire a newfound appreciation for the genius that lies within.

Early Life and Background

Post Malone was born Austin Richard Post on July 4, 1995, in Syracuse, New York. He spent his early years in a family passionate about music, which greatly influenced his artistic development. https://www.aceshowbiz.com/celebrity/post_malone/ His father introduced him to various genres, while his father was a DJ. This exposure to music at a young age sparked Post's interest in pursuing a career in the industry.

At the age of nine, Post Malone moved to Grapevine, Texas, after his parents' separation. It was there that he began to hone his craft, becoming proficient in playing the guitar and experimenting with music production software. His teenage years were marked by a fascination with different musical styles, blending elements of rock, hip-hop, and R&B, which would later define his unmistakable sound.

After graduating from high school, Post Malone took a leap of faith by relocating to Los Angeles to pursue a music career. His determination and unique style set him apart from his peers, leading to the creation of his breakout single "White Iverson." This song garnered significant attention and marked the beginning of Post Malone's ascent in the music industry, showing that his early influences were shaping him into a future superstar.

Musical Journey and Breakthrough

Post Malone's musical journey began in Syracuse, New York, where he was raised. His passion for music was ignited at a young age, influenced by a diverse range of genres from rock to hip hop. By the age of 14, he taught himself to play the guitar and started experimenting with music production software. This early exposure shaped his unique sound, blending elements of various genres that would later define his style.

In 2015, Post Malone released his debut single "White Iverson," which quickly went viral and caught the attention of music industry insiders. The track's success marked a significant turning point in his career, leading to a record deal with Republic Records. Following this breakthrough, he gained widespread recognition and began to collaborate with well-known artists. His ability to seamlessly incorporate different musical influences helped propel him to the forefront of the contemporary music scene.

Post Malone's debut album, "Stoney," released in 2016, solidified his status as a major player in the industry. With hits like "Congratulations" and "Go Flex," the album showed off his genre-blurring style and emotional depth. As he continued to push musical boundaries, Post Malone became a voice for a generation, resonating with listeners worldwide and earning numerous accolades along the way.

Influences and Collaborations

Post Malone's musical journey has been significantly shaped by a diverse range of influences, which is evident in his unique sound. He draws inspiration from various genres including hip-hop, rock, and country, allowing him to blend elements from each to create a distinctive style. Artists like Nirvana, 50 Cent, and Bob Dylan have all left impressions on his music, reflecting his eclectic taste and ability to craft songs that resonate with a wide audience.

Collaboration has been a key aspect of Post Malone's career, allowing him to experiment and expand his musical horizons. His partnerships with other artists have resulted in some of the biggest hits in recent years. Collaborating with the likes of Ty Dolla Sign, Swae Lee, and Ozzy Osbourne showcases his versatility and willingness to step outside the box, combining different artistic visions to achieve greater heights.

The synergy between Post Malone and his collaborators often leads to groundbreaking tracks. His song "Sunflower" with Swae Lee, featured in the Spider-Man: Into the Spider-Verse soundtrack, is a perfect example of how collaborations can transcend traditional genre boundaries and attract a global audience. These creative partnerships not only elevate his music but also contribute to the ongoing evolution of contemporary pop culture.

Impact on Pop Culture

Post Malone has become a defining figure in modern pop culture, merging diverse musical genres and appealing to a broad audience. His ability to seamlessly blend hip-hop, rock, and pop has led to a unique sound that resonates with fans from various backgrounds. Tracks like "Sunflower" and "Circles" showcase his versatility and have become anthems for a generation navigating complex emotions and experiences.

His distinct style and persona have also made waves in fashion and social media. Often seen in oversized clothing and unique accessories, Post has set trends that many fans eagerly emulate. His tattoos and unconventional looks challenge traditional standards of beauty and masculinity, allowing fans to embrace their individuality. Through his active presence on platforms like Instagram and TikTok, he cultivates a relatable image, making him accessible to millions.

Furthermore, Post Malone's collaborations with other artists have often sparked cultural conversations. Collaborating with various genres, he has worked with legends and emerging artists alike, bridging gaps and creating dialogues within the music community. This openness in collaboration has not only refined his musical craft but has also influenced how artists view genre boundaries, inspiring a more inclusive approach to music creation and appreciation.

Philanthropy and Personal Life

Post Malone is not only recognized for his chart-topping hits but also for his significant contributions to various charitable causes. Throughout his career, he has demonstrated a commitment to giving back to the community. In 2020, he hosted a virtual concert benefiting the Covid-19 relief effort, raising substantial funds while keeping fans entertained during challenging times. His support for organizations like the Grammy Foundation and local charities showcases his dedication to making a positive impact.

In his personal life, Post Malone values his privacy but has shared glimpses of his interests and passions. He enjoys playing video games and often connects with fans through this medium. His authentic personality shines through, endearing him to both audiences and colleagues. Post also has a close relationship with his family, frequently expressing gratitude for their support throughout his journey in the music industry.

Despite his fame, Post Malone stays grounded, often highlighting the importance of mental health and self-care. He advocates for open conversations about mental wellness and the pressures that come with being in the spotlight. Through his philanthropic efforts and personal ethos, he aims to inspire others, proving that success can go hand in hand with compassion and community involvement.

te splint were repaired.Clusterin (CLU) was the first reported secreted mammalian chaperone and impacts on serious diseases associated with inappropriate extracellular protein aggregation. Many studies have described intracellular CLU in locations outside the secretory system and recent work has shown that CLU can be released into the cytosol during cell stress. In this article, we critically evaluate evidence relevant to the proposed origins of cellular CLU found outside the secretory system, and advance the hypothesis that the cytosolic release of CLU induced by stress serves to facilitate the trafficking of misfolded proteins to the proteasome and autophagy for degradation. We also propose future research directions that could help establish CLU as a unique chaperone performing critical and synergic roles in both intracellular and extracellular proteostasis.Chromatin interactions functionally affect genome architecture and gene regulation, but to date, only fresh samples must be used in Hi-C (High-through chromosome conformation capture) to keep natural chromatin conformation intact. This requirement has impeded the advancement of 3D genome research by limiting sample collection and storage options for researchers and severely limiting the number of samples that can be processed in a short time. Here, we developed a freeze substitution Hi-C (FS-Hi-C) technique that overcomes the need for fresh samples. FS-Hi-C can be used with samples stored in liquid nitrogen (LN2) the water in a vitreous form in the sample cells is replaced with ethanol via automated freeze substitution. After confirming that the FS step preserves the natural chromosome conformation during sample thawing, we tested the performance of FS-Hi-C with Drosophila melanogaster and Gossypium hirsutum. Beyond allowing the use of frozen samples and confirming that FS-Hi-C delivers robust data for generating contact heat maps and delineating A/B compartments and topologically associating domains, we found that FS-Hi-C outperforms the in situ Hi-C in terms of library quality, reproducibility, and valid interactions. Thus, FS-Hi-C will probably extend the application of 3D genome structure analysis to the vast number of experimental contexts in biological and medical research for which Hi-C methods have been unfeasible to date.
This study aim was to review cases of acinic cell carcinoma (the main differential diagnosis of secretory carcinoma) that were diagnosed and treated at the National Cancer Institute of Brazil (INCA) between 1996 and 2016. The primary objective was to identify underdiagnosed cases of secretory carcinoma via a clinical, immunopathological and molecular reassessment.

This is a cross sectional study, with retrospective data collection from medical records and histological specimen review, with staining for periodic acid-Schiff (PAS) and PAS with diastase, immunohistochemistry for S-100, mammaglobin, and DOG-1, and droplet digital RT-PCR for ETV6-NTRK3. The Research Ethics Committee approved this study, and the patients allowed their participation through informed consent.

Eighty-three cases of acinic cell carcinoma were diagnosed and treated in the specified period at INCA, of which, seven had their diagnosis changed to secretory carcinoma.

The present study adds seven cases of secretory carcinoma to the literature, contributing to a better understanding of the epidemiological, histological, immunohistochemical and molecular characteristics of this recently described tumor. Also, the use of a comprehensive diagnostic approach, including immunohistochemical and molecular methods, along with classical morphological studies, allowed the reclassification of acinic cell carcinoma to secretory carcinoma.
The present study adds seven cases of secretory carcinoma to the literature, contributing to a better understanding of the epidemiological, histological, immunohistochemical and molecular characteristics of this recently described tumor. Also, the use of a comprehensive diagnostic approach, including immunohistochemical and molecular methods, along with classical morphological studies, allowed the reclassification of acinic cell carcinoma to secretory carcinoma.
The ACSM recommends drinking to avoid loss of body mass >2% during exercise to avert compromised performance. Our study aimed to assess the level of dehydration in elite runners following a city marathon in a tropical environment.

Prospective cohort design.

Twelve elite runners (6 males, 6 females; age 24-41 y) had body mass measured to the nearest 0.01kg in their race attire immediately before and after the 2017 Standard Chartered Singapore Marathon 2017. Body mass change was corrected for respiratory water loss, gas exchange, and sweat retained in clothing, and expressed as % of pre-race mass (i.e. % dehydration).

Data are expressed as means±SD (range). Dry bulb temperature and humidity were 27.9±0.1°C (27.4-28.3°C) and 79±2% (73-82%). Finish time was 155±10min (143-172min). https://www.selleckchem.com/products/mk-0159.html Male runners finishing positions ranged from 2-12 out of 7627 finishers, whilst female runners placed 1-8 out of 1754 finishers. Body mass change (loss) and % dehydration for all runners were 2.5±0.5kg (1.8-3.5kg) and 4.6±0.9% (3.6-6.8%). Male runners experienced body mass loss of 2.8±0.5kg and 4.9±1.2% while females experienced body mass loss of 2.1±0.2kg and 4.3±0.6%.

Despite experiencing dehydration (4.6% body mass loss) two-fold higher than current fluid replacement guidelines recommend (≤2%), elite male and female runners performed successfully and without medical complication in a hot weather marathon.
Despite experiencing dehydration (4.6% body mass loss) two-fold higher than current fluid replacement guidelines recommend (≤2%), elite male and female runners performed successfully and without medical complication in a hot weather marathon.Sleep paralysis is a curious condition where the paralyzed person may hallucinate terrifying ghosts. These hypnogogic and hypnopompic visions are common worldwide. They often entail seeing and sensing shadow beings; although hallucinating full-fledged figures (e.g., cat-like creatures and witches) are not uncommon. In this paper, I propose a neuroscientific account (building on previous work) for why people see ghosts during sleep paralysis and why these tend to manifest as faceless shadows. This novel venture considers the distinct computational styles of the right and left hemisphere and their functional specializations vis-à-vis florid intruder hallucinations and out-of-body experiences (OBEs) during these dream-like states. Additionally, I provide a brain-based explanation for dissociative phenomena common during sleep paralysis. Specifically, I posit that these ghost hallucinations and OBEs are chiefly mediated by activity in key regions in the right hemisphere; and outline how the functional organization of the visual system (evoking concepts like surface interpolation) and its economizing nature (i.

Background Male breast cancer (MBC) is rare, and most previous studies limited their focus on clinical aspects of the disease. Psychosocial implications and care needs of MBC patients are poorly understood. Objectives The aim of this study is to explore the experiences of men living with breast cancer and to identify supportive care needs. Methods Eighteen men were interviewed using qualitative, semi-structured telephone interviews. Qualitative content analysis was used to analyze the data. Results The majority of men did not have negative feelings about having a "women's disease," although some felt that stigmatization threatened their masculinity. Male sex was perceived as hindering access to adequate care. Patients identified key barriers including (1) a lack of awareness and experience of treating males among health professionals; (2) treatment and available information were based on evidence for females; and (3) lacking support services. Conclusion To improve MBC care, it is important to raise awareness of the disease and to adapt treatment strategies, patient information, and support services to meet the needs of men. Copyright © 2019 by S. Karger AG, Basel.Bladder cancer (BC) is the sixth most common malignancy in men and 17th in women. Exosomal long non-coding RNAs (lncRNAs) have been defined as a novel biomarker for BC. The aim of this study is to evaluate the clinical significance of urine exosomal PVT-1, ANRIL and PCAT-1 as a biomarker in BC patients with tumors classified as T1 or T2. Exosomes were isolated from urine of BC patients and healthy donors, then characterized according to their shape, size, and exosome markers by Electron Microscopy, Dynamic light scattering, and Western blotting. Exosomal lncRNAs extraction was done to determine the expression levels of PVT-1, ANRIL and PCAT-1 by qRT-PCR. ANRIL and PCAT-1 expression was significantly higher in BC patients compared to normal subjects. To evaluate the performance of the identified lncRNAs for BC detection, we performed ROC curves analysis. The diagnostic accuracy of ANRIL and PCAT-1, measured by AUC, was 0.7229 (sensitivity = 46.67 % and specificity = 87.5 %) and 0.7292 (sensitivity = 43.33 % and specificity = 87.5 %). Transcript levels of lncRNAs in urinary exosomes are potential diagnostic biomarkers in bladder cancer. Copyright © 2020 Abbastabar et al.Background. Adherence to Mediterranean dietary patterns reduces the incidence of cardiovascular disease and other major chronic diseases. We aimed to assess the association between participation in kitchen-based nutrition education and Mediterranean diet intake and lifestyle medicine counseling competencies among medical trainees. Methods. https://www.selleckchem.com/products/AZD6244.html The Cooking for Health Optimization with Patients (CHOP) curriculum is a hands-on cooking-based nutrition education program implemented at 32 medical programs (4125 medical trainees) across the United States. Mediterranean diet intake, nutrition attitudes, and lifestyle medicine counseling competencies were assessed via validated surveys. Multivariable-adjusted logistic regression assessed the relationship of CHOP education with Mediterranean diet intake, nutrition attitudes, and lifestyle medicine counseling competencies. Results. Individuals participating in the CHOP program were 82% more likely to follow the Mediterranean diet compared with those receiving traditional nutrition education (OR = 1.82; P less then .001). CHOP participants were more likely to satisfy daily intake of fruits (OR = 1.33; P = .019) and vegetables (OR = 2.06; P less then .001) and agree that nutrition counseling should be a routine component of clinical care (OR = 2.43; P less then .001). Kitchen-based nutrition education versus traditional curricula is associated with a higher likelihood of total counseling competency involving 25 lifestyle medicine categories (OR = 1.67; P less then .001). Conclusion. Kitchen-based nutrition education is associated with cardioprotective dietary patterns and lifestyle medicine counseling among medical trainees. © 2020 The Author(s).Precision medicine has captured the imagination of the medical community with visions of therapies precisely targeted to the specific individual's genetic, biological, social, and environmental profile. However, in practice it has become synonymous with genomic medicine. As such its successes have been limited, with poor predictive or clinical value for the majority of people. It adds little to lifestyle medicine, other than in establishing why a healthy lifestyle is effective in combatting chronic disease. The challenge of lifestyle medicine remains getting people to actually adopt, sustain, and naturalize a healthy lifestyle, and this will require an approach that treats the patient as a person with individual needs and providing them with suitable types of support. The future of lifestyle medicine is holistic and person-centered rather than technological. © 2019 The Author(s).The 2019 Addendum, in conjunction with the original health and wellness coaching (HWC) Compendium, organizes HWC literature with the aim of assisting researchers while providing a resource for practitioners. The 2019 Addendum to the HWC Compendium extends the initial work by adding HWC-related literature published in the past 2 years. The 2019 Addendum divides articles retrieved into 8 categories, including a new miscellaneous section complementing categories examining HWC effects on cancer, cholesterol, diabetes, heart disease, hypertension, obesity, and wellness. The 2019 Addendum again provides in-depth information about the nature, quality, and results from each article in a detailed spreadsheet provided as an electronic appendix. The 2019 Addendum contributes another 104 peer-reviewed coaching-related articles to the HWC Compendium. This most recent research again describes HWC as a favorable intervention with treatment potential in all categories, though only 3 new cancer articles were included in the 2019 Addendum. Trends in HWC (ie, e-coaching and group coaching) are identified, and there is also discussion of future research needs. In conclusion, the field of HWC continues to grow, as does the research describing this clinical practice; the 2019 Addendum to the Compendium of HWC organizes and assists understanding of this literature. © 2019 The Author(s).

[J Contin Educ Nurs. 2020;51(3)109-117.]. Copyright 2020, SLACK Incorporated.There has been increasing focus on improving the quality and safety of health care globally. Understanding that the health of one nation impacts others worldwide drives initiatives for collaboration to improve the health of all. In this, the Year of the Nurse and Midwife as designated by the World Health Organization, The Quality and Safety Education for Nurses (QSEN) Competencies provide structure that transcends culture for framing the nursing role to contribute to improving patient safety and the quality of care delivery internationally. This article describes initiatives to share resources and strategies to support quality and safety education and practice with nurses across countries. [J Contin Educ Nurs. 2020;51(3)106-108.]. Copyright 2020, SLACK Incorporated.Associations come and go, as do their brands, missions, and visions. Nursing has many associations and affiliated groups because the profession is diverse, complex, and collaborative. Engagement in professional organizations is a critical contribution to career and leadership development. The organization formerly known as the Council on Graduate Education for Administration in Nursing has been functioning for nearly 50 years, but its new brand-Association for Leadership Science in Nursing-and mission bring a fresh and compelling value proposition. [J Contin Educ Nurs. 2020;51(3)104-105.]. Copyright 2020, SLACK Incorporated.Plenary panel planning and implementation, carried out by temporary teams, are described for nursing organizations and professional development across settings. The conference or meeting theme and objectives frame panel member selection and moderator focus. Panelist conversations highlight different career trajectories and connect with attendees. [J Contin Educ Nurs. 2020;51(3)100-102.]. Copyright 2020, SLACK Incorporated.Sex chromosomes contribute substantially to key evolutionary processes such as speciation and adaptation. Several theories suggest that evolution could occur more rapidly on sex chromosomes, but currently our understanding of whether and how this occurs is limited. Here, we present an analysis of the great tit (Parus major) genome, aiming to detect signals of faster-Z evolution. We find mixed evidence of faster divergence on the Z chromosome than autosomes, with significantly higher divergence being found in ancestral repeats, but not at 4-fold or 0-fold degenerate sites. Interestingly, some 4-fold sites appear to be selectively constrained, which may mislead analyses that use these sites as the neutral reference (e.g., dN/dS). Consistent with other studies in birds, the mutation rate is significantly higher in males than females, and the long-term Z-to-autosome effective population size ratio is only 0.5, significantly lower than the expected value of 0.75. These are indicative of male-driven evolution and high variance in male reproductive success, respectively. We find no evidence for an increased efficacy of positive selection on the Z chromosome. In contrast, the Z chromosome in great tits appears to be affected by increased genetic drift, which has led to detectable signals of weakened intensity of purifying selection. These results provide further evidence that the Z chromosome often has a low effective population size, and that this has important consequences for its evolution. They also highlight the importance of considering multiple factors that can affect the rate of evolution and effective population sizes of sex chromosomes. © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.CONTEXT/OBJECTIVE In insulin resistant subjects, hyperinsulinemia is a key compensatory mechanism, aimed at maintaining glucose homeostasis. Increased secretion and reduced clearance of insulin may both potentially contribute to this phenomenon. Insulin resistance and hyperinsulinemia are common findings in women with polycystic ovary syndrome (PCOS). While there is some information on insulin secretion, very few studies have investigated metabolic clearance rate of insulin (MCRI) in these women. Moreover, there is paucity of data on the relationships between MCRI and the pathophysiological characteristics of PCOS. The aim of the study was to explore these issues. PATIENTS One hundred and ninety women with PCOS, diagnosed according to the Rotterdam criteria, with normal glucose tolerance. DESIGN Assessment of MCRI and clinical, hormonal and metabolic characteristics of subjects. MCRI and insulin sensitivity were measured by the hyperinsulinemic euglycemic clamp. Serum androgens were assessed by liquid chromatography-mass spectrometry and equilibrium dialysis. A historical sample of healthy women was used to define the corresponding reference intervals. RESULTS MCRI was impaired in about two thirds of women with PCOS. Subjects with low MCRI differed from those with normal MCRI for a number of anthropometric, metabolic and endocrine features. In multivariate analysis, degree of adiposity, estimates of insulin secretion and serum androgen concentrations were independent predictors of MCRI. Conversely, age, adiposity, MCRI and insulin sensitivity, but not serum androgens, were independent predictors of insulin secretion. CONCLUSIONS In women with PCOS metabolic clearance of insulin is reduced, contributing to generating hyperinsulinemia. Serum androgens are independent predictors of this phenomenon. https://www.selleckchem.com/products/ly3023414.html © Endocrine Society 2020. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.Importance In response to the national opioid public health crisis, there is an urgent need to develop nonopioid solutions for effective pain management. Neurosteroids are endogenous molecules with pleotropic actions that show promise for safe and effective treatment of chronic low back pain. Objective To determine whether adjunctive pregnenolone has therapeutic utility for the treatment of chronic low back pain in Iraq- and Afghanistan-era US military veterans. Design, Setting, and Participants Randomized, double-blind, placebo-controlled clinical trial that enrolled for 42 months, from September 2013 to April 2017. Participants were Iraq- and Afghanistan-era veterans aged 18 to 65 years with chronic low back pain who received treatment in the Durham VA Health Care System in Durham, North Carolina, over 6 weeks. Data analysis began in 2018 and was finalized in March, 2019. Interventions Following a 1-week placebo lead-in, participants were randomized to pregnenolone or placebo for 4 weeks. Pregnenolone and placebo were administered at fixed, escalating doses of 100 mg for 1 week, 300 mg for 1 week, and 500 mg for 2 weeks.

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