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51 mins ago


© The Author(s) 2020. Published by Oxford University Press on behalf of the American Burn Association. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.Regional metastasis is the single most important prognostic factor in oral squamous cell carcinoma (OSCC). https://www.selleckchem.com/products/sw-100.html Abnormal expression of N-myc downstream-regulated genes (NDRGs) has been identified to occur in several tumor types and to predict poor prognosis. In OSCC, the clinical significance of deregulated NDRG expression has not been fully established. In this study, NDRG1 relevance was assessed at gene and protein level in 100 OSCC patients followed-up by at least 10 years. Survival outcome was analyzed using a multivariable analysis. Tumor progression and metastasis was investigated in preclinical model using oral cancer cell lines (HSC3, SCC25) treated with EGF and orthotopic mouse model of metastatic murine OSCC (AT84). We identified NDRG1 expression levels to be significantly lower in patients with metastatic tumors compared to patients with local disease only (P=0.001). NDRG1 expression was associated with MMP-2, -9, -10 (P=0.022, P=0.002, P=0.042, respectively), and BCL2 (P=0.035). NDRG1 lower expression was able to predict recurrence and metastasis (log-rank test, P=0.001). In multivariable analysis, the expression of NDRG1 was an independent prognostic factor (Cox regression, P=0.013). In invasive OSCC cells, NDRG1 expression is diminished in response to EGF and this was associated with a potent induction of epithelial-mesenchymal transition (EMT) phenotype. This result was further confirmed in an orthotopic OSCC mouse model. Together, this data support that NDRG1 down-regulation is a potential predictor of metastasis and approaches aimed at NDRG1 signaling rescue can serve as potential therapeutic strategy to prevent oral cancer progression to metastasis. © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email journals.permissions@oup.com.In a cluster randomized trial (CRT), groups of people are randomly assigned to different interventions. Existing parametric and semiparametric methods for CRTs rely on distributional assumptions or a large number of clusters to maintain nominal confidence interval (CI) coverage. Randomization-based inference is an alternative approach that is distribution-free and does not require a large number of clusters to be valid. Although it is well-known that a CI can be obtained by inverting a randomization test, this requires testing a non-zero null hypothesis, which is challenging with non-continuous and survival outcomes. In this article, we propose a general method for randomization-based CIs using individual-level data from a CRT. This approach accommodates various outcome types, can account for design features such as matching or stratification, and employs a computationally efficient algorithm. We evaluate this method's performance through simulations and apply it to the Botswana Combination Prevention Project, a large HIV prevention trial with an interval-censored time-to-event outcome. © The Author 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.In the sector of occupational safety and health only a limited amount of studies are concerned with the conversion of inhalable to respirable dust. This conversion is of high importance for retrospective evaluations of exposure levels or of occupational diseases. For this reason a possibility to convert inhalable into respirable dust is discussed in this study. To determine conversion functions from inhalable to respirable dust fractions, 15 120 parallel measurements in the exposure database MEGA (maintained at the Institute for Occupational Safety and Health of the German Social Accident Insurance) are investigated by regression analysis. For this purpose, the whole data set is split into the influencing factors working activity and material. Inhalable dust is the most important predictor variable and shows an adjusted coefficient of determination of 0.585 (R2 adjusted to sample size). Further improvement of the model is gained, when the data set is split into six working activities and three material groups behalf of the British Occupational Hygiene Society.OBJECTIVES Compare the morphologic, laboratory, and clinical features of asymptomatic and symptomatic Castleman disease in the pediatric population. METHODS We reviewed clinical records and histopathology of patients with Castleman disease from 2 pediatric institutions. RESULTS Of 39 patients with pediatric Castleman disease, 37 had unicentric disease, all classified with the hyaline vascular variant of Castleman disease, 8 of which were clinically symptomatic. These 8 patients demonstrated abnormal laboratory findings, including microcytic anemia, elevated erythrocyte sedimentation rate and C-reactive protein, and hypoalbuminemia. In addition, histopathologic evaluation showed that the 8 symptomatic cases had more hyperplastic germinal centers, fewer atrophic or regressed germinal centers, fewer mantle zones containing multiple germinal centers, reduced "onion skinning" of mantle zones, and fewer "lollipop" formations compared with the asymptomatic cases. CONCLUSIONS This series of pediatric Castleman disease showed that lymph nodes from asymptomatic patients generally demonstrated the more classic hyaline vascular histology, whereas those with symptoms could lack or have only focal classic findings. As such, reactive lymph nodes with subtle Castleman-like features should prompt clinical correlation to ensure proper diagnosis. © American Society for Clinical Pathology, 2020. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.Sweetness enhancement by aromas has been suggested as a strategy to mitigate sugar reduction in food products, but enhancement is dependent on type of aroma as well as sugar level. A careful screening of aromas across sugar levels is thus required. Screening results might, however, depend on the method employed. Both descriptive sensory analysis and relative to reference scaling were therefore used to screen 5 aromas across 3 sucrose concentrations for their sweetness enhancing effects in aqueous solutions. In the descriptive analysis, samples with added vanilla, honey, and banana aroma were rated as significantly sweeter than samples with added elderflower or raspberry aroma at all sucrose concentrations. In relative to reference scaling, honey aroma significantly increased the sweet taste compared to samples with added elderflower or no aroma at low and medium sucrose concentrations. Banana and raspberry aromas also increased the sweet taste significantly compared to the sample with added elderflower aroma at medium sucrose concentration in the relative to reference scaling.

1 hr ago


The performance of the proposed imaging system is validated with in vivo and ex vivo targets. The experimental results obtained from several tungsten filaments in the depth range of 1.2 mm, show an improvement of -6 dB lateral resolution from 55-287 μm to 25-29 μm and also an improvement of signal-to-noise ratio (SNR) from 16-22 dB to 27-33 dB in the proposed system.The Purkinje system is a heart structure responsible for transmitting electrical impulses through the ventricles in a fast and coordinated way to trigger mechanical contraction. Estimating a patient-specific compatible Purkinje Network from an electro-anatomical map is a challenging task, that could help to improve models for electrophysiology simulations or provide aid in therapy planning, such as radiofrequency ablation. In this study, we present a methodology to inversely estimate a Purkinje network from a patient's electro-anatomical map. First, we carry out a simulation study to assess the accuracy of the method for different synthetic Purkinje network morphologies and myocardial junction densities. Second, we estimate the Purkinje network from a set of 28 electro-anatomical maps from patients, obtaining an optimal conduction velocity in the Purkinje network of 1.95 ± 0.25 m/s, together with the location of their Purkinje-myocardial junctions, and Purkinje network structure. Our results showed an average local activation time error of 6.8 ± 2.2 ms in the endocardium. Finally, using the personalized Purkinje network, we obtained correlations higher than 0.85 between simulated and clinical 12-lead ECGs.Cine cardiac magnetic resonance imaging (MRI) is widely used for the diagnosis of cardiac diseases thanks to its ability to present cardiovascular features in excellent contrast. As compared to computed tomography (CT), MRI, however, requires a long scan time, which inevitably induces motion artifacts and causes patients' discomfort. Thus, there has been a strong clinical motivation to develop techniques to reduce both the scan time and motion artifacts. Given its successful applications in other medical imaging tasks such as MRI super-resolution and CT metal artifact reduction, deep learning is a promising approach for cardiac MRI motion artifact reduction. In this paper, we propose a novel recurrent generative adversarial network model for cardiac MRI motion artifact reduction. This model utilizes bi-directional convolutional long short-term memory (ConvLSTM) and multi-scale convolutions to improve the performance of the proposed network, in which bi-directional ConvLSTMs handle long-range temporal features while multi-scale convolutions gather both local and global features. We demonstrate a decent generalizability of the proposed method thanks to the novel architecture of our deep network that captures the essential relationship of cardiovascular dynamics. Indeed, our extensive experiments show that our method achieves better image quality for cine cardiac MRI images than existing state-of-the-art methods. https://www.selleckchem.com/products/gsk2334470.html In addition, our method can generate reliable missing intermediate frames based on their adjacent frames, improving the temporal resolution of cine cardiac MRI sequences.Regression-based face alignment involves learning a series of mapping functions to predict the true landmark from an initial estimation of the alignment. Most existing approaches focus on learning efficacious mapping functions from some feature representations to improve performance. The issues related to the initial alignment estimation and the final learning objective, however, receive less attention. This work proposes a deep regression architecture with progressive reinitialization and a new error-driven learning loss function to explicitly address the above two issues. Given an image with a rough face detection result, the full face region is firstly mapped by a supervised spatial transformer network to a normalized form and trained to regress coarse positions of landmarks. Then, different face parts are further respectively reinitialized to their own normalized states, followed by another regression sub-network to refine the landmark positions. To deal with the inconsistent annotations in existing training datasets, we further propose an adaptive landmark-weighted loss function. It dynamically adjusts the importance of different landmarks according to their learning errors during training without depending on any hyper-parameters manually set by trial and error. The whole deep architecture permits training from end to end, and extensive experimental comparisons demonstrate its effectiveness and efficiency.Representations in the form of Symmetric Positive Definite (SPD) matrices have been popularized in a variety of visual learning applications due to their demonstrated ability to capture rich second-order statistics of visual data. There exist several similarity measures for comparing SPD matrices with documented benefits. However, selecting an appropriate measure for a given problem remains a challenge and in most cases, is the result of a trial-and-error process. In this paper, we propose to learn similarity measures in a data-driven manner. To this end, we capitalize on the alpha-beta-log-det divergence, which is a meta-divergence parametrized by scalars alpha and beta, subsuming a wide family of popular information divergences on SPD matrices for distinct and discrete values of these parameters. Our key idea is to cast these parameters in a continuum and learn them from data. We systematically extend this idea to learn vector-valued parameters, thereby increasing the expressiveness of the underlying non-linear measure. We conjoin the divergence learning problem with several standard tasks in machine learning, including supervised discriminative dictionary learning and unsupervised SPD matrix clustering. We present Riemannian descent schemes for optimizing our formulations efficiently and show the usefulness of our method on eight standard computer vision tasks.This paper proposes a novel distance metric learning algorithm, named adaptive neighborhood metric learning (ANML). In ANML, we design two thresholds to adaptively identify the inseparable similar and dissimilar samples in the training procedure, thus inseparable sample removing and metric parameter learning are implemented in the same procedure. Due to the non-continuity of the proposed ANML, we develop a log-exp mean function to construct a continuous formulation to surrogate it. The proposed method has interesting properties. For example, when ANML is used to learn the linear embedding, current famous metric learning algorithms such as the large margin nearest neighbor (LMNN) and neighbourhood components analysis (NCA) are the special cases of the proposed ANML by setting the parameters different values. Besides, compared with LMNN and NCA, ANML has a broader searching space which may contain better solutions. When it is used to learn deep features, the state-of-the-art deep metric learning algorithms such as Triplet loss, Lifted structure loss, and Multi-similarity loss become the special cases of our method. Furthermore, the proposed log-exp mean function gives a new perspective to review deep metric learning methods such as Prox-NCA and N-pairs loss. Experiments are conducted to demonstrate the effectiveness of the proposed method.We propose the first stochastic framework to employ uncertainty for RGB-D saliency detection by learning from the data labeling process. Existing RGB-D saliency detection models treat this task as a point estimation problem by predicting a single saliency map following a deterministic learning pipeline. We argue that, however, the deterministic solution is relatively ill-posed. Inspired by the saliency data labeling process, we propose a generative architecture to achieve probabilistic RGB-D saliency detection which utilizes a latent variable to model the labeling variations. Our framework includes two main models 1) a generator model, which maps the input image and latent variable to stochastic saliency prediction, and 2) an inference model, which gradually updates the latent variable by sampling it from the true or approximate posterior distribution. The generator model is an encoder-decoder saliency network. To infer the latent variable, we introduce two different solutions i) a Conditional Variational Auto-encoder with an extra encoder to approximate the posterior distribution of the latent variable; and ii) an Alternating Back-Propagation technique, which directly samples the latent variable from the true posterior distribution. Qualitative and quantitative results on six challenging RGB-D benchmark datasets show our approach's superior performance in learning the distribution of saliency maps.This paper generalizes the Attention in Attention (AiA) mechanism, proposed in [1], by employing explicit mapping in reproducing kernel Hilbert spaces to generate attention values of the input feature map. The AiA mechanism models the capacity of building inter-dependencies among the local and global features by the interaction of inner and outer attention modules. Besides a vanilla AiA module, termed linear attention with AiA, two non-linear counterparts, namely, second-order polynomial attention and Gaussian attention, are also proposed to utilize the non-linear properties of the input features explicitly, via the second-order polynomial kernel and Gaussian kernel approximation. The deep convolutional neural network, equipped with the proposed AiA blocks, is referred to as Attention in Attention Network (AiA-Net). The AiA-Net learns to extract a discriminative pedestrian representation, which combines complementary person appearance and corresponding part features. Extensive ablation studies verify the effectiveness of the AiA mechanism and the use of non-linear features hidden in the feature map for attention design. Furthermore, our approach outperforms current state-of-the-art by a considerable margin across a number of benchmarks. In addition, state-of-the-art performance is also achieved in the video person retrieval task with the assistance of the proposed AiA blocks.The popularity of deep learning techniques renewed the interest in neural architectures able to process complex structures that can be represented using graphs, inspired by Graph Neural Networks (GNNs). We focus our attention on the originally proposed GNN model of Scarselli et al. 2009, which encodes the state of the nodes of the graph by means of an iterative diffusion procedure that, during the learning stage, must be computed at every epoch, until the fixed point of a learnable state transition function is reached, propagating the information among the neighbouring nodes. We propose a novel approach to learning in GNNs, based on constrained optimization in the Lagrangian framework. Learning both the transition function and the node states is the outcome of a joint process, in which the state convergence procedure is implicitly expressed by a constraint satisfaction mechanism, avoiding iterative epoch-wise procedures and the network unfolding. Our computational structure searches for saddle points of the Lagrangian in the adjoint space composed of weights, nodes state variables and Lagrange multipliers. This process is further enhanced by multiple layers of constraints that accelerate the diffusion process. An experimental analysis shows that the proposed approach compares favourably with popular models on several benchmarks.

2 hrs ago


If you are a coffee enthusiast, you recognize that the right syrup can lift your caffeinated masterpieces to new heights. Coffee syrup pumping systems are essential equipment for both house brewers and baristas, allowing for exact dispensing of flavours that may transform some sort of simple mug of coffee directly into a flavored work of genius. Whether https://www.openlearning.com/u/kernmunro-sk24ic/blog/FillPerfectionTheSkillOfCoffeeViscousSyrupPumps would like to drizzle vanilla, hazelnut, caramel, or even any other preferred flavor, using a syrup pump ensures that you obtain the perfect amount each time.

Throughout cafes and the kitchen alike, syrup dispensers play a vital role in streamlining the beverage-making method. Coffee syrup dispensers not only improve the flavor but likewise include a professional touch for your drinks. With different varieties of viscous syrup pump dispensers obtainable, finding the proper that you suit the needs can make a lot of difference in offering a regular and scrumptious experience. Let’s dance to the world involving coffee syrup penis pumps and discover how to revolutionize your caffeine game.





Types regarding Syrup Pumps

When it comes to espresso syrup pumps, generally there are various types designed to meet different needs. One particular popular type is definitely the manual viscous syrup pump, which functions with a basic push or move mechanism. This type is frequently favored intended for its simplicity in addition to ease of make use of, which makes it ideal intended for small cafes or home users which want to eliminates syrup without challenging machinery. These pushes are generally made through durable materials to assure longevity and steady performance.

Another type is the electric syrup push, which offers some sort of more automated option for high-volume settings. Electric pumps may dispense consistent portions of syrup on the push of the button, reducing toil and the possibility of mess in active environments like caffeine shops or dining establishments. This type regarding pump can be developed for different thick syrup amounts, allowing baristas to craft drinks with precision. Their very own efficiency makes them a well-liked option for organizations looking to reduces costs of their beverage planning process.

Finally, there are portion control syrup pumps that aid manage syrup usage effectively. These pumps are designed to dispense a new fixed level of thick syrup per pump, producing it easier to be able to control costs and even maintain consistent flavor in every refreshment. Ideal for franchises or establishments with specific recipe requirements, these types of pumps promote durability and reduce waste. Along with a variety of alternatives available, users will get the right syrup dispenser to fit their unique detailed needs.

How to be able to Use Coffee Thick syrup Pumps

Using coffee thick syrup pumps is straightforward plus can enhance your own beverage experience substantially. First, ensure that your coffee viscous syrup pump is clear and properly set up. Before filling, this is recommended to give the pump a fast rinse with cozy water to remove any residual syrup by previous uses. As soon as cleaned, secure it to a bottle of wine of your favorite coffee syrup, aiming the pump along with the neck associated with the bottle.

To eliminates the syrup, basically press down in the pump mind. Most syrup penis pumps offer a consistent volume of syrup using each press, typically ranging from fifty percent an ounce for an ounce. Start together with one pump intended for a milder sweetness and adjust according to your taste preference. If you are unsure, it’s always preferable to commence with less viscous syrup as you can easily always add more to achieve your current desired flavor.

After work with, remember to close up the bottle firmly and store this within a cool place. You will need to clean the particular pump in case you switch between different flavours to prevent cross-contamination of syrup tastes. Regular maintenance will make sure that your java syrup dispenser continues to be functional and your own drinks taste just right every time.

Maintenance and Cleansing Tips

To make sure your java syrup pumps function effectively, regular servicing is vital. Start by inspecting the pump motor for any leaking or signs of wear. Make some sort of habit of checking out the seals in addition to O-rings, as these kinds of components can use out with time in addition to may require alternative. Keeping the pumping systems well-maintained not just extends their lifespan but also helps to ensure that you get a new consistent flow regarding syrup every time.

Cleaning your own syrup dispensers is definitely crucial for preserving hygiene and stopping flavor contamination. Right after each use, rinse out the pump in addition to dispenser with comfortable water to remove any residual viscous syrup. To get a deeper clear, disassemble the pump motor according to the manufacturer’s instructions and wash all components with a mild detergent. Rinse thoroughly to make certain right now there is no soap residue that may affect the preference of your coffee syrups.

Finally, to always keep your coffee viscous syrup dispensers in top rated condition, store these questions cool, dry location when not within use. Avoid coverage to direct sun light or extreme conditions, as these problems can degrade typically the materials and cause malfunctions. Setting a cleaning schedule can also be helpful, ensuring of which your equipment is usually always ready for make use of and enhancing the overall coffee knowledge for your buyers.


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Posts

51 mins ago


© The Author(s) 2020. Published by Oxford University Press on behalf of the American Burn Association. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.Regional metastasis is the single most important prognostic factor in oral squamous cell carcinoma (OSCC). https://www.selleckchem.com/products/sw-100.html Abnormal expression of N-myc downstream-regulated genes (NDRGs) has been identified to occur in several tumor types and to predict poor prognosis. In OSCC, the clinical significance of deregulated NDRG expression has not been fully established. In this study, NDRG1 relevance was assessed at gene and protein level in 100 OSCC patients followed-up by at least 10 years. Survival outcome was analyzed using a multivariable analysis. Tumor progression and metastasis was investigated in preclinical model using oral cancer cell lines (HSC3, SCC25) treated with EGF and orthotopic mouse model of metastatic murine OSCC (AT84). We identified NDRG1 expression levels to be significantly lower in patients with metastatic tumors compared to patients with local disease only (P=0.001). NDRG1 expression was associated with MMP-2, -9, -10 (P=0.022, P=0.002, P=0.042, respectively), and BCL2 (P=0.035). NDRG1 lower expression was able to predict recurrence and metastasis (log-rank test, P=0.001). In multivariable analysis, the expression of NDRG1 was an independent prognostic factor (Cox regression, P=0.013). In invasive OSCC cells, NDRG1 expression is diminished in response to EGF and this was associated with a potent induction of epithelial-mesenchymal transition (EMT) phenotype. This result was further confirmed in an orthotopic OSCC mouse model. Together, this data support that NDRG1 down-regulation is a potential predictor of metastasis and approaches aimed at NDRG1 signaling rescue can serve as potential therapeutic strategy to prevent oral cancer progression to metastasis. © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email journals.permissions@oup.com.In a cluster randomized trial (CRT), groups of people are randomly assigned to different interventions. Existing parametric and semiparametric methods for CRTs rely on distributional assumptions or a large number of clusters to maintain nominal confidence interval (CI) coverage. Randomization-based inference is an alternative approach that is distribution-free and does not require a large number of clusters to be valid. Although it is well-known that a CI can be obtained by inverting a randomization test, this requires testing a non-zero null hypothesis, which is challenging with non-continuous and survival outcomes. In this article, we propose a general method for randomization-based CIs using individual-level data from a CRT. This approach accommodates various outcome types, can account for design features such as matching or stratification, and employs a computationally efficient algorithm. We evaluate this method's performance through simulations and apply it to the Botswana Combination Prevention Project, a large HIV prevention trial with an interval-censored time-to-event outcome. © The Author 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.In the sector of occupational safety and health only a limited amount of studies are concerned with the conversion of inhalable to respirable dust. This conversion is of high importance for retrospective evaluations of exposure levels or of occupational diseases. For this reason a possibility to convert inhalable into respirable dust is discussed in this study. To determine conversion functions from inhalable to respirable dust fractions, 15 120 parallel measurements in the exposure database MEGA (maintained at the Institute for Occupational Safety and Health of the German Social Accident Insurance) are investigated by regression analysis. For this purpose, the whole data set is split into the influencing factors working activity and material. Inhalable dust is the most important predictor variable and shows an adjusted coefficient of determination of 0.585 (R2 adjusted to sample size). Further improvement of the model is gained, when the data set is split into six working activities and three material groups behalf of the British Occupational Hygiene Society.OBJECTIVES Compare the morphologic, laboratory, and clinical features of asymptomatic and symptomatic Castleman disease in the pediatric population. METHODS We reviewed clinical records and histopathology of patients with Castleman disease from 2 pediatric institutions. RESULTS Of 39 patients with pediatric Castleman disease, 37 had unicentric disease, all classified with the hyaline vascular variant of Castleman disease, 8 of which were clinically symptomatic. These 8 patients demonstrated abnormal laboratory findings, including microcytic anemia, elevated erythrocyte sedimentation rate and C-reactive protein, and hypoalbuminemia. In addition, histopathologic evaluation showed that the 8 symptomatic cases had more hyperplastic germinal centers, fewer atrophic or regressed germinal centers, fewer mantle zones containing multiple germinal centers, reduced "onion skinning" of mantle zones, and fewer "lollipop" formations compared with the asymptomatic cases. CONCLUSIONS This series of pediatric Castleman disease showed that lymph nodes from asymptomatic patients generally demonstrated the more classic hyaline vascular histology, whereas those with symptoms could lack or have only focal classic findings. As such, reactive lymph nodes with subtle Castleman-like features should prompt clinical correlation to ensure proper diagnosis. © American Society for Clinical Pathology, 2020. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.Sweetness enhancement by aromas has been suggested as a strategy to mitigate sugar reduction in food products, but enhancement is dependent on type of aroma as well as sugar level. A careful screening of aromas across sugar levels is thus required. Screening results might, however, depend on the method employed. Both descriptive sensory analysis and relative to reference scaling were therefore used to screen 5 aromas across 3 sucrose concentrations for their sweetness enhancing effects in aqueous solutions. In the descriptive analysis, samples with added vanilla, honey, and banana aroma were rated as significantly sweeter than samples with added elderflower or raspberry aroma at all sucrose concentrations. In relative to reference scaling, honey aroma significantly increased the sweet taste compared to samples with added elderflower or no aroma at low and medium sucrose concentrations. Banana and raspberry aromas also increased the sweet taste significantly compared to the sample with added elderflower aroma at medium sucrose concentration in the relative to reference scaling.

1 hr ago


The performance of the proposed imaging system is validated with in vivo and ex vivo targets. The experimental results obtained from several tungsten filaments in the depth range of 1.2 mm, show an improvement of -6 dB lateral resolution from 55-287 μm to 25-29 μm and also an improvement of signal-to-noise ratio (SNR) from 16-22 dB to 27-33 dB in the proposed system.The Purkinje system is a heart structure responsible for transmitting electrical impulses through the ventricles in a fast and coordinated way to trigger mechanical contraction. Estimating a patient-specific compatible Purkinje Network from an electro-anatomical map is a challenging task, that could help to improve models for electrophysiology simulations or provide aid in therapy planning, such as radiofrequency ablation. In this study, we present a methodology to inversely estimate a Purkinje network from a patient's electro-anatomical map. First, we carry out a simulation study to assess the accuracy of the method for different synthetic Purkinje network morphologies and myocardial junction densities. Second, we estimate the Purkinje network from a set of 28 electro-anatomical maps from patients, obtaining an optimal conduction velocity in the Purkinje network of 1.95 ± 0.25 m/s, together with the location of their Purkinje-myocardial junctions, and Purkinje network structure. Our results showed an average local activation time error of 6.8 ± 2.2 ms in the endocardium. Finally, using the personalized Purkinje network, we obtained correlations higher than 0.85 between simulated and clinical 12-lead ECGs.Cine cardiac magnetic resonance imaging (MRI) is widely used for the diagnosis of cardiac diseases thanks to its ability to present cardiovascular features in excellent contrast. As compared to computed tomography (CT), MRI, however, requires a long scan time, which inevitably induces motion artifacts and causes patients' discomfort. Thus, there has been a strong clinical motivation to develop techniques to reduce both the scan time and motion artifacts. Given its successful applications in other medical imaging tasks such as MRI super-resolution and CT metal artifact reduction, deep learning is a promising approach for cardiac MRI motion artifact reduction. In this paper, we propose a novel recurrent generative adversarial network model for cardiac MRI motion artifact reduction. This model utilizes bi-directional convolutional long short-term memory (ConvLSTM) and multi-scale convolutions to improve the performance of the proposed network, in which bi-directional ConvLSTMs handle long-range temporal features while multi-scale convolutions gather both local and global features. We demonstrate a decent generalizability of the proposed method thanks to the novel architecture of our deep network that captures the essential relationship of cardiovascular dynamics. Indeed, our extensive experiments show that our method achieves better image quality for cine cardiac MRI images than existing state-of-the-art methods. https://www.selleckchem.com/products/gsk2334470.html In addition, our method can generate reliable missing intermediate frames based on their adjacent frames, improving the temporal resolution of cine cardiac MRI sequences.Regression-based face alignment involves learning a series of mapping functions to predict the true landmark from an initial estimation of the alignment. Most existing approaches focus on learning efficacious mapping functions from some feature representations to improve performance. The issues related to the initial alignment estimation and the final learning objective, however, receive less attention. This work proposes a deep regression architecture with progressive reinitialization and a new error-driven learning loss function to explicitly address the above two issues. Given an image with a rough face detection result, the full face region is firstly mapped by a supervised spatial transformer network to a normalized form and trained to regress coarse positions of landmarks. Then, different face parts are further respectively reinitialized to their own normalized states, followed by another regression sub-network to refine the landmark positions. To deal with the inconsistent annotations in existing training datasets, we further propose an adaptive landmark-weighted loss function. It dynamically adjusts the importance of different landmarks according to their learning errors during training without depending on any hyper-parameters manually set by trial and error. The whole deep architecture permits training from end to end, and extensive experimental comparisons demonstrate its effectiveness and efficiency.Representations in the form of Symmetric Positive Definite (SPD) matrices have been popularized in a variety of visual learning applications due to their demonstrated ability to capture rich second-order statistics of visual data. There exist several similarity measures for comparing SPD matrices with documented benefits. However, selecting an appropriate measure for a given problem remains a challenge and in most cases, is the result of a trial-and-error process. In this paper, we propose to learn similarity measures in a data-driven manner. To this end, we capitalize on the alpha-beta-log-det divergence, which is a meta-divergence parametrized by scalars alpha and beta, subsuming a wide family of popular information divergences on SPD matrices for distinct and discrete values of these parameters. Our key idea is to cast these parameters in a continuum and learn them from data. We systematically extend this idea to learn vector-valued parameters, thereby increasing the expressiveness of the underlying non-linear measure. We conjoin the divergence learning problem with several standard tasks in machine learning, including supervised discriminative dictionary learning and unsupervised SPD matrix clustering. We present Riemannian descent schemes for optimizing our formulations efficiently and show the usefulness of our method on eight standard computer vision tasks.This paper proposes a novel distance metric learning algorithm, named adaptive neighborhood metric learning (ANML). In ANML, we design two thresholds to adaptively identify the inseparable similar and dissimilar samples in the training procedure, thus inseparable sample removing and metric parameter learning are implemented in the same procedure. Due to the non-continuity of the proposed ANML, we develop a log-exp mean function to construct a continuous formulation to surrogate it. The proposed method has interesting properties. For example, when ANML is used to learn the linear embedding, current famous metric learning algorithms such as the large margin nearest neighbor (LMNN) and neighbourhood components analysis (NCA) are the special cases of the proposed ANML by setting the parameters different values. Besides, compared with LMNN and NCA, ANML has a broader searching space which may contain better solutions. When it is used to learn deep features, the state-of-the-art deep metric learning algorithms such as Triplet loss, Lifted structure loss, and Multi-similarity loss become the special cases of our method. Furthermore, the proposed log-exp mean function gives a new perspective to review deep metric learning methods such as Prox-NCA and N-pairs loss. Experiments are conducted to demonstrate the effectiveness of the proposed method.We propose the first stochastic framework to employ uncertainty for RGB-D saliency detection by learning from the data labeling process. Existing RGB-D saliency detection models treat this task as a point estimation problem by predicting a single saliency map following a deterministic learning pipeline. We argue that, however, the deterministic solution is relatively ill-posed. Inspired by the saliency data labeling process, we propose a generative architecture to achieve probabilistic RGB-D saliency detection which utilizes a latent variable to model the labeling variations. Our framework includes two main models 1) a generator model, which maps the input image and latent variable to stochastic saliency prediction, and 2) an inference model, which gradually updates the latent variable by sampling it from the true or approximate posterior distribution. The generator model is an encoder-decoder saliency network. To infer the latent variable, we introduce two different solutions i) a Conditional Variational Auto-encoder with an extra encoder to approximate the posterior distribution of the latent variable; and ii) an Alternating Back-Propagation technique, which directly samples the latent variable from the true posterior distribution. Qualitative and quantitative results on six challenging RGB-D benchmark datasets show our approach's superior performance in learning the distribution of saliency maps.This paper generalizes the Attention in Attention (AiA) mechanism, proposed in [1], by employing explicit mapping in reproducing kernel Hilbert spaces to generate attention values of the input feature map. The AiA mechanism models the capacity of building inter-dependencies among the local and global features by the interaction of inner and outer attention modules. Besides a vanilla AiA module, termed linear attention with AiA, two non-linear counterparts, namely, second-order polynomial attention and Gaussian attention, are also proposed to utilize the non-linear properties of the input features explicitly, via the second-order polynomial kernel and Gaussian kernel approximation. The deep convolutional neural network, equipped with the proposed AiA blocks, is referred to as Attention in Attention Network (AiA-Net). The AiA-Net learns to extract a discriminative pedestrian representation, which combines complementary person appearance and corresponding part features. Extensive ablation studies verify the effectiveness of the AiA mechanism and the use of non-linear features hidden in the feature map for attention design. Furthermore, our approach outperforms current state-of-the-art by a considerable margin across a number of benchmarks. In addition, state-of-the-art performance is also achieved in the video person retrieval task with the assistance of the proposed AiA blocks.The popularity of deep learning techniques renewed the interest in neural architectures able to process complex structures that can be represented using graphs, inspired by Graph Neural Networks (GNNs). We focus our attention on the originally proposed GNN model of Scarselli et al. 2009, which encodes the state of the nodes of the graph by means of an iterative diffusion procedure that, during the learning stage, must be computed at every epoch, until the fixed point of a learnable state transition function is reached, propagating the information among the neighbouring nodes. We propose a novel approach to learning in GNNs, based on constrained optimization in the Lagrangian framework. Learning both the transition function and the node states is the outcome of a joint process, in which the state convergence procedure is implicitly expressed by a constraint satisfaction mechanism, avoiding iterative epoch-wise procedures and the network unfolding. Our computational structure searches for saddle points of the Lagrangian in the adjoint space composed of weights, nodes state variables and Lagrange multipliers. This process is further enhanced by multiple layers of constraints that accelerate the diffusion process. An experimental analysis shows that the proposed approach compares favourably with popular models on several benchmarks.

2 hrs ago


If you are a coffee enthusiast, you recognize that the right syrup can lift your caffeinated masterpieces to new heights. Coffee syrup pumping systems are essential equipment for both house brewers and baristas, allowing for exact dispensing of flavours that may transform some sort of simple mug of coffee directly into a flavored work of genius. Whether https://www.openlearning.com/u/kernmunro-sk24ic/blog/FillPerfectionTheSkillOfCoffeeViscousSyrupPumps would like to drizzle vanilla, hazelnut, caramel, or even any other preferred flavor, using a syrup pump ensures that you obtain the perfect amount each time.

Throughout cafes and the kitchen alike, syrup dispensers play a vital role in streamlining the beverage-making method. Coffee syrup dispensers not only improve the flavor but likewise include a professional touch for your drinks. With different varieties of viscous syrup pump dispensers obtainable, finding the proper that you suit the needs can make a lot of difference in offering a regular and scrumptious experience. Let’s dance to the world involving coffee syrup penis pumps and discover how to revolutionize your caffeine game.





Types regarding Syrup Pumps

When it comes to espresso syrup pumps, generally there are various types designed to meet different needs. One particular popular type is definitely the manual viscous syrup pump, which functions with a basic push or move mechanism. This type is frequently favored intended for its simplicity in addition to ease of make use of, which makes it ideal intended for small cafes or home users which want to eliminates syrup without challenging machinery. These pushes are generally made through durable materials to assure longevity and steady performance.

Another type is the electric syrup push, which offers some sort of more automated option for high-volume settings. Electric pumps may dispense consistent portions of syrup on the push of the button, reducing toil and the possibility of mess in active environments like caffeine shops or dining establishments. This type regarding pump can be developed for different thick syrup amounts, allowing baristas to craft drinks with precision. Their very own efficiency makes them a well-liked option for organizations looking to reduces costs of their beverage planning process.

Finally, there are portion control syrup pumps that aid manage syrup usage effectively. These pumps are designed to dispense a new fixed level of thick syrup per pump, producing it easier to be able to control costs and even maintain consistent flavor in every refreshment. Ideal for franchises or establishments with specific recipe requirements, these types of pumps promote durability and reduce waste. Along with a variety of alternatives available, users will get the right syrup dispenser to fit their unique detailed needs.

How to be able to Use Coffee Thick syrup Pumps

Using coffee thick syrup pumps is straightforward plus can enhance your own beverage experience substantially. First, ensure that your coffee viscous syrup pump is clear and properly set up. Before filling, this is recommended to give the pump a fast rinse with cozy water to remove any residual syrup by previous uses. As soon as cleaned, secure it to a bottle of wine of your favorite coffee syrup, aiming the pump along with the neck associated with the bottle.

To eliminates the syrup, basically press down in the pump mind. Most syrup penis pumps offer a consistent volume of syrup using each press, typically ranging from fifty percent an ounce for an ounce. Start together with one pump intended for a milder sweetness and adjust according to your taste preference. If you are unsure, it’s always preferable to commence with less viscous syrup as you can easily always add more to achieve your current desired flavor.

After work with, remember to close up the bottle firmly and store this within a cool place. You will need to clean the particular pump in case you switch between different flavours to prevent cross-contamination of syrup tastes. Regular maintenance will make sure that your java syrup dispenser continues to be functional and your own drinks taste just right every time.

Maintenance and Cleansing Tips

To make sure your java syrup pumps function effectively, regular servicing is vital. Start by inspecting the pump motor for any leaking or signs of wear. Make some sort of habit of checking out the seals in addition to O-rings, as these kinds of components can use out with time in addition to may require alternative. Keeping the pumping systems well-maintained not just extends their lifespan but also helps to ensure that you get a new consistent flow regarding syrup every time.

Cleaning your own syrup dispensers is definitely crucial for preserving hygiene and stopping flavor contamination. Right after each use, rinse out the pump in addition to dispenser with comfortable water to remove any residual viscous syrup. To get a deeper clear, disassemble the pump motor according to the manufacturer’s instructions and wash all components with a mild detergent. Rinse thoroughly to make certain right now there is no soap residue that may affect the preference of your coffee syrups.

Finally, to always keep your coffee viscous syrup dispensers in top rated condition, store these questions cool, dry location when not within use. Avoid coverage to direct sun light or extreme conditions, as these problems can degrade typically the materials and cause malfunctions. Setting a cleaning schedule can also be helpful, ensuring of which your equipment is usually always ready for make use of and enhancing the overall coffee knowledge for your buyers.


3 hrs ago


Have you been some sort of coffee enthusiast searching to elevate your beverage game? In case so, you might want to find out the magic regarding coffee syrup pushes. These handy equipment, often overlooked, can turn your ordinary caffeine into a charming experience, transforming your current morning routine plus adding a feel of flair in your favorite brews. Along with endless flavor options and the ease of precise dispensing, coffee https://www.coffeehype.co.uk/collections/coffee-tampers/ deserve a place within your kitchen.

Imagine having a perfect blend regarding sweet flavors ready to enhance your caffeine creations. Whether you prefer classic vanilla, rich caramel, or something more daring, syrup pumps are necessary for delivering just the right amount without the particular mess. As we all dive to the globe of syrup dispensers and coffee syrup dispensers, you can uncover the positive aspects and top features of these innovative tools, making sure every cup is a masterpiece focused on your taste.

Knowing Syrup Pumps

Syrup pumps are essential tools in coffee shops and restaurants, created to dispense the liquid sugar syrups efficiently. These pumps give a controlled and even consistent way in order to add syrup to beverages, ensuring that will every cup of joe or even specialty drink offers the perfect amount of sweetness. The design typically allows with regard to a precise portioning system, which is definitely especially useful inside high-volume environments where time and accuracy are key.

Coffee thick syrup pumps come throughout various sizes plus styles, catering in order to different needs. Several pumps are made for countertop work with, while others may be mounted or incorporated into bar setups. They might handle a broad range of thick syrup types, including flavoured syrups, creamers, and pure sugar syrups. This versatility makes it a popular selection for both business establishments and home baristas who would like to raise their coffee knowledge.

The use of syrup dispenser pumps not only enhances the productivity of syrup program but also will help reduce waste. Simply by allowing for specific measurements, these pumping systems limit the overpouring that may occur together with traditional pouring procedures. This aspect is particularly necessary for companies aiming to control costs while supplying high-quality beverages. Purchasing a reliable syrup pump motor dispenser can substantially improve the total service experience inside any coffee-centric atmosphere.



Choosing the Appropriate Coffee Syrup Répartir

When selecting a coffee viscous syrup dispenser, consider the size and capacity that best fits your own needs. If you're serving a significant group, a dispenser having a larger potential will save time plus reduce the frequency of refills. Conversely, if it's for personal use or some sort of small café, some sort of compact model may suffice. It's important to strike the balance between ease and space needs, ensuring that the particular dispenser fits nicely on the countertop or service area.

Another crucial factor may be the variety of pump mechanism. Some syrup pumping systems offer a pull-down lever mechanism whilst others have a force button design. Typically the lever-style is normally more ergonomically friendly regarding high-volume use, enabling you to dispense syrup quickly and even efficiently. Meanwhile, force button pumps may possibly be easier to work for casual work with and can supply precise control above the quantity dispensed, preventing waste and making sure consistency in your beverages.

Finally, consider the ease of cleaning repairs and maintanance. A coffee syrup dispenser should end up being straightforward to take apart and clean, specifically if you decide to use multiple types of syrups. Models together with smooth surfaces plus fewer crevices are generally easier to maintain. Additionally, look regarding dispensers produced from sturdy materials that may withstand repeated employ, whether you're a busy café owner or an enthusiastic house brewer. Making the right choice ensures you enjoy your favorite coffee creations using minimal hassle.

Servicing and Tips with regard to Longevity

To ensure your coffee syrup penis pumps remain functional and even reliable, regular washing is essential. Following every use, take a moment to rinse the pump using hot water to remove any residual thick syrup. This simple stage prevents stickiness and even build-up, which will intervene with the stream of syrup on your next serving. For the more thorough washing, disassemble the pump according to typically the manufacturer’s instructions and soak the pieces in a slight soap solution ahead of rinsing them thoroughly.

Correct handling and storage area of syrup pumping systems can also prolong their lifespan. Maintain your pumps inside a cool, dry out place when not in use, and prevent exposing them to extreme temperatures or sunlight. If you are usually using multiple viscous syrup dispensers, label them to prevent mixing tastes, which can affect taste and consistency. This practice not really only helps maintain the quality of your coffee syrups but in addition saves time when preparing your drinks.



Lastly, usually monitor the problem of the seals and gaskets on your syrup pumping systems. These components are very important for maintaining a leak-free operation. If you see any signs associated with wear or destruction, replace them immediately to avoid syrup leakages and keep optimal functionality. Regular checks plus proactive maintenance will certainly keep your java syrup dispensers throughout top shape, making certain every cup of coffee is mixed with just the right quantity of sweetness.


5 hrs ago


There are some things truly unique in regards to the aroma of freshly brewed espresso which could brighten anyone's day. For java lovers and newbies alike, finding the particular perfect blend can easily be a wonderful journey, but at times that journey could be overwhelming. That is where espresso bundles come in to play, offering some sort of curated selection involving flavors and roasts designed to focus on every palate. Whether or not you prefer typically the bold richness of a dark beef roasts or the easy elegance of a new light blend, these types of bundles provide the opportunity to check out new tastes minus the hassle.

Coffee gift lots are not only a treat intended for yourself; they create for thoughtful products that show a person care. Imagine astonishing a friend or family member using a carefully assembled coffee package, complete with unique combines and specialty tastes. From artisanal charcoal grill to sustainably found options, there is usually a coffee package deal for every celebration, be it a new birthday, holiday, or even just a basic gesture of appreciation. Sign up for us as we all uncover the diverse associated with coffee packages and guide an individual in selecting the particular perfect one in order to raise your coffee encounter.

Types of Coffee Lots

If exploring the world of coffee bundles, 1 can find some sort of variety of options tailored to various tastes and personal preferences. A popular choice is the particular single-origin coffee bundle, which typically features beans sourced from a specific place, highlighting the distinctive flavors and characteristics intrinsic to of which area. These bundles allow coffee enthusiasts to explore the particular distinct profiles that various regions possess to offer, through the fruity notes associated with Ethiopian beans towards the chocolatey undertones associated with Colombian varieties.



Another alluring option is the particular flavored coffee package deal. These bundles cater to people who appreciate a twist to their coffee experience, presenting beans infused with a range of wonderful flavors such since vanilla, hazelnut, or even caramel. Flavored espresso bundles are perfect for men and women looking to include a bit of pleasure for their morning program or as a great indulgent treat during a cozy evening break. They are also an effective way to introduce new preference experiences without straying too far from the comforting world regarding coffee.

For anyone gift-giving occasions, coffee gift packages make the perfect choice. These bundles often include a curated assortment of coffees, along with complementary items for instance mugs, accessories, or perhaps gourmet snacks. Espresso gift bundles are made to create a wonderful experience for the particular recipient, making them really feel appreciated and special. Whether for any bday, holiday, or just mainly because, these bundles offer an opportunity in order to share the happiness of coffee throughout a thoughtful in addition to personalized way.

Deciding on the best Gift Bundle

Selecting the right coffee gift bundle can be some sort of delightful adventure, especially with the wide range available to fit every taste. Begin by simply considering the recipient's preferences. Do they will enjoy bold in addition to robust flavors, or perhaps do they lean toward lighter, more fragile brews? Understanding their own palate will guide you in picking a bundle that they can truly appreciate and luxuriate in. Look for choices that showcase different roasts and origins to provide a comprehensive sampling experience.

Another factor is definitely the brewing technique your recipient makes use of. Different coffee bundles cater to various brewing styles, such as drip, French click, or espresso. Several bundles may include ground coffee, although others feature complete beans for those who like to grind their own coffee fresh. Being attentive to their preferred method will ensure that the gift will be not only pleasant but in addition convenient with regard to them to make use of.

Lastly, consider the the labels and presentation involving the coffee present bundle. A well-packaged bundle can boost the overall gifting experience. Look with regard to bundles that come in beautiful packing containers or baskets, often accompanied by contributory items such while mugs or snack foods. Aesthetic appeal adds another touch associated with thoughtfulness to the gift, so that it is memorable and appreciated.

Leading Recommendations for Coffee Lovers

When it arrives to https://www.coffeehype.co.uk/collections/coffee-bundles/ , the options are nearly endless, each catering to diverse taste preferences. For those who appreciate a classic coffee encounter, consider a bundle that will includes a choice of medium-roast beans through various regions. This kind of bundle often features popular origins like Colombian and Brazilian coffees, which are known for their balanced taste profiles and clean finish. Enjoy brewing a morning mug that embodies the essence of these highly respected beans.

For the exciting coffee drinker, a variety pack including single-origin and experimental mixes can be some sort of thrilling choice. These bundles can have distinctive flavors and nose, featuring beans through Ethiopia or Kenya, known for their own fruity and floral notes. Such a selection clears the way to be able to tasting new flavor experiences, making every single cup a delightful big surprise. Pair this bundle with a mouth watering guide to enhance the brewing voyage.

Ultimately, coffee gift lots are perfect with regard to those looking in order to treat a buddy or even loved one. These types of curated packages generally include not just a choice of espresso beans but likewise complementary items such as high-quality mugs, tasting syrups, or non-industriel pastries. Coffee gift idea bundles allow people to explore fresh flavors while savoring the little luxuries of a well-made mug. They earn for considerate presents, perfect intended for any occasion, honoring the joy involving coffee.