& like 'Time flies' & with coming 1/20/2025 of Trump-JD Vance etc Team better 2 have 24/7 swing shifts working around the clock as 365 days multiplied 2 years = 730 days & then 4 years = 1,460 days 2 literally TRY & UNDO 50-100 years of corruption ETC fill in blanks; tick tock.

Judy Mikovits a former associate of Anthony Stephen Fauci who worked along side him B4 she really SELF deemed what he was doing was (?), OH SO WRONG in so many way's & on so many level's so she 'bounced' (as we say from the streets), she chose her own more safer independent path. See amidst book's thereof 'Plague of Corruption' - https://web.archive.org/web/*/https://plaguethebook.com

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State-of-the art selection methods fail to identify weak but cumulative effects of features found in many high-dimensional omics datasets. Nevertheless, these features play an important role in certain diseases. We present Netboost, a three-step dimension reduction technique. First, a boosting-based filter is combined with the topological overlap measure to identify the essential edges of the network. Second, sparse hierarchical clustering is applied on the selected edges to identify modules and finally module information is aggregated by the first principal components. We demonstrate the application of the newly developed Netboost in combination with CoxBoost for survival prediction of DNA methylation and gene expression data from 180 acute myeloid leukemia (AML) patients and show, based on cross-validated prediction error curve estimates, its prediction superiority over variable selection on the full dataset as well as over an alternative clustering approach. The identified signature related to chromatin modifying enzymes was replicated in an independent dataset, the phase II AMLSG 12-09 study. In a second application we combine Netboost with Random Forest classification and improve the disease classification error in RNA-sequencing data of Huntington's disease mice. Netboost is a freely available Bioconductor R package for dimension reduction and hypothesis generation in high-dimensional omics applications.A novel implantable and externally controllable stem-cell-based platform for the treatment of Glioblastoma brain cancer has been proposed to bring hope to patients who suffer from this devastating cancer type. Induced Neural Stem Cells (iNSCs), known to have potent therapeutic effects through exosomes-based molecular communication, play a pivotal role in this platform. Transplanted iNSCs demonstrate long-term survival and differentiation into neurons and glia which then fully functionally integrate with the existing neural network. Recent studies have shown that specific types of calcium channels in differentiated neurons and astrocytes are inhibited or activated upon cell depolarization leading to the increased intracellular calcium concentration levels which, in turn, interact with mobilization of multivesicular bodies and exosomal release. In order to provide a platform towards treating brain cancer with the optimum therapy dosage, we propose mathematical models to compute the therapeutic exosomal release rate that is modulated by cell stimulation patterns applied from the external wearable device. This study serves as an initial and required step in the evaluation of controlled exosomal secretion and release via induced stimulation with electromagnetic, optical and/or ultrasonic waves.Image deraining is an important yet challenging image processing task. Though deterministic image deraining methods are developed with encouraging performance, they are infeasible to learn flexible representations for probabilistic inference and diverse predictions. Besides, rain intensity varies both in spatial locations and across color channels, making this task more difficult. https://www.selleckchem.com/products/bgj398-nvp-bgj398.html In this paper, we propose a Conditional Variational Image Deraining (CVID) network for better deraining performance, leveraging the exclusive generative ability of Conditional Variational Auto-Encoder (CVAE) on providing diverse predictions for the rainy image. To perform spatially adaptive deraining, we propose a spatial density estimation (SDE) module to estimate a rain density map for each image. Since rain density varies across different color channels, we also propose a channel-wise (CW) deraining scheme. Experiments on synthesized and real-world datasets show that the proposed CVID network achieves much better performance than previous deterministic methods on image deraining. Extensive ablation studies validate the effectiveness of the proposed SDE module and CW scheme in our CVID network. The code is available at https//github.com/Yingjun-Du/VID.In this paper, we propose a deep CNN to tackle the image restoration problem by learning formatted information. Previous deep learning based methods directly learn the mapping from corrupted images to clean images, and may suffer from the gradient exploding/vanishing problems of deep neural networks. We propose to address the image restoration problem by learning the structured details and recovering the latent clean image together, from the shared information between the corrupted image and the latent image. In addition, instead of learning the pure difference (corruption), we propose to add a residual formatting layer and an adversarial block to format the information to structured one, which allows the network to converge faster and boosts the performance. Furthermore, we propose a cross-level loss net to ensure both pixel-level accuracy and semantic-level visual quality. Evaluations on public datasets show that the proposed method performs favorably against existing approaches quantitatively and qualitatively.Computing the convolution between a 2D signal and a corresponding filter with variable orientations is a basic problem that arises in various tasks ranging from low level image processing (e.g. ridge/edge detection) to high level computer vision (e.g. pattern recognition). Through decades of research, there still lacks an efficient method for solving this problem. In this paper, we investigate this problem from the perspective of approximation by considering the following problem what is the optimal basis for approximating all rotated versions of a given bivariate function? Surprisingly, solely minimising the L2-approximation-error leads to a rotation-covariant linear expansion, which we name Fourier-Argand representation. This representation presents two major advantages 1) rotation-covariance of the basis, which implies a "strong steerability" - rotating by an angle α corresponds to multiplying each basis function by a complex scalar e-ikα; 2) optimality of the Fourier-Argand basis, which ensures a few number of basis functions suffice to accurately approximate complicated patterns and highly direction-selective filters. We show the relation between the Fourier-Argand representation and the Radon transform, leading to an efficient implementation of the decomposition for digital filters. We also show how to retrieve accurate orientation of local structures/patterns using a fast frequency estimation algorithm.