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17 mins ago


In the vast expanse of the internet, there exists a hidden realm often overlooked by the average user. This intriguing world is home to what are known as onion lists, a fascinating aspect of the deep web. While mainstream websites are easily accessible, https://virtuous-pear-mx5fx2.mystrikingly.com/blog/peeling-back-layers-the-ultimate-guide-to-onion-lists s offer a glimpse into a more anonymous and often mysterious digital landscape, showcasing a variety of content that can range from the benign to the controversial.

Onion lists are essentially directories of hidden services that utilize the Tor network, enabling users to explore websites that are not indexed by conventional search engines. These lists serve as gateways to a plethora of resources, communities, and information that are shielded from the prying eyes of the surface web. As we peel back the layers of onion lists, we uncover the myriad ways they influence privacy, security, and even activism on the internet, beckoning us to delve deeper into this unique and often enigmatic environment.

What are Onion Lists?

Onion lists are curated collections of links that provide access to various websites hosted on the dark web. These lists serve as a gateway for users who seek content that is not indexed by traditional search engines. The term 'onion' refers to the way in which these websites are accessed through the Tor network, where layers of encryption resemble the layers of an onion. This makes onion lists an essential resource for anyone looking to navigate the complex dark web landscape.

Typically, onion lists contain links that end with the .onion domain, which can only be reached using specific software like Tor. This unique domain structure ensures anonymity for both users and site operators, creating a space for a wide range of content, from the innocuous to the illegal. These lists may include forums, marketplaces, information sites, and much more, making them a diverse and sometimes controversial part of the internet.

Moreover, onion lists can vary significantly in terms of the content they host and the communities they serve. Some lists focus on specific themes, such as privacy advocacy or whistleblowing platforms, while others may aggregate links to various marketplaces that deal in goods and services that are often considered illicit. Understanding the nature of these lists is crucial for anyone interested in discovering the hidden corners of the internet, as they provide a glimpse into a world that operates outside the reach of mainstream online activity.



How Onion Lists are Used

Onion lists serve as crucial resources in the realm of online privacy and security. They organize and present a variety of websites and services that are accessible via the Tor network. Users seeking anonymity can consult these lists to find hidden services, such as forums, marketplaces, and whistleblowing platforms. By directing users to .onion sites, these lists promote a safer browsing experience, encouraging individuals to access content without compromising their identities.

Additionally, onion lists are instrumental for researchers and journalists who are investigating topics often shrouded in secrecy. With access to the right onion list, they can uncover valuable information and connect with sources that may not be available through conventional means. This aspect helps to shine a light on issues that may otherwise be neglected by mainstream media, contributing to a broader understanding of critical global matters.

Finally, onion lists facilitate discussions within communities that prioritize privacy and security. They often include user-generated ratings and comments, enabling users to evaluate the trustworthiness of various .onion sites. This collective knowledge fosters a more informed user base, helping individuals navigate the complexities of the deep web while minimizing risks associated with online activities.

The Future of Onion Lists

As the digital landscape continues to evolve, onion lists are likely to adapt and grow in complexity. With the increased focus on privacy and cybersecurity, more users may turn to these decentralized platforms for sharing and accessing information. Onion lists could expand beyond basic content sharing to include tools for enhanced anonymity and security, catering to those who prioritize their digital footprint. The merging of technology with privacy considerations may lead to innovative uses of onion lists, making them a staple in online interactions.

The role of onion lists could also be influenced by emerging regulations around data privacy. As governments implement stricter laws to protect user data, onion lists may serve as a refuge for those seeking to sidestep intrusive surveillance practices. This shift could encourage the development of more robust platforms that prioritize user control and data security. As a result, onion lists might not only provide anonymity but also create a safe space for free expression, fostering communities that challenge conventional norms.

Finally, the growth of decentralized technologies such as blockchain could revolutionize how onion lists are created and maintained. This integration could enhance transparency and trust among users while ensuring that the information shared remains untouchable by external forces. Moreover, as more individuals become aware of the risks associated with traditional internet usage, the reliance on onion lists may increase, ushering in an era of greater acceptance and innovation in these unique online spaces.


 Onion lists have become a crucial component of navigating the dark web, serving as directories that link to various hidden services and sites. These lists provide users with a way

virtuous-pear-mx5fx2.mystrikingly.com

19 mins ago


Only 25% of studies using matching reported calculating robust standard errors for the PS analyses.

The quality of reporting of PS methods in the MS literature is sub-optimal in general, and in some cases, inappropriate methods are used.
The quality of reporting of PS methods in the MS literature is sub-optimal in general, and in some cases, inappropriate methods are used.
Compassion meditation (CM) training has demonstrated potential in improving well-being and psychosocial functioning. However, most prior studies of CM training have focused on younger adults. The generalizability of the effectiveness of CM training with older adults requires further study. This pilot study was intended to inform future randomized controlled studies of CM training in older adults.

Participants included 24 older adults who attended a 10-week group CM training. Exploratory outcome measures were administered prior to, during, and after the intervention. Participants also completed logs of mood and meditation practice, and provided descriptive comments in response to open-ended questions administered at the end of treatment.

High treatment completion rates (87.5%) and reported adherence (85.7% of assigned meditation) were observed. Descriptive feedback from participants indicated older adults are interested in and capable of learning and applying new concepts and skills in support of their well-being. Pre- to post-intervention changes were explored with a variety of self-report measures. Weekly journals suggested increased feelings of love, closeness, or trust, and decreased feelings of stress, nervousness, or being overwhelmed.

These findings provide preliminary support for the feasibility of CM training in community-dwelling older adults, and suggest the need for future efficacy and effectiveness clinical trials.

CM training offers potential benefits for improving well-being among older adults, and, as an example of a strengths-based approach, can be tailored to the specific needs of older adults.
CM training offers potential benefits for improving well-being among older adults, and, as an example of a strengths-based approach, can be tailored to the specific needs of older adults.Tonsils are believed to be the initial site of the John Cunningham virus (JCV) infection. The long-term effect of childhood tonsillectomy on JCV status in multiple sclerosis (MS) patients has not been investigated. In this retrospective case-control study, we analyzed data of 144 JCV seropositive cases and 82 JCV seronegative controls from three outpatient MS clinics in the United States. Early tonsillectomy (before the age of 8) was reported among 8 (5.56%) JCV seropositive subjects and 19 (23.17%) controls. Early tonsillectomy was associated with JCV negative status (adjusted odds ratio = 5.39, 95% confidence interval = 2.13-13.62, p  less then  0.001) independent of age and gender.Shiga toxin (Stx)-producing Escherichia coli (STEC) can cause a wide range of symptoms from asymptomatic carriage, mild diarrhea to bloody diarrhea (BD) and hemolytic uremic syndrome (HUS). Intimin, encoded by the eae gene, also plays a critical role in STEC pathogenesis. Herein, we investigated the prevalence and genetic diversity of eae among clinical STEC isolates from patients with diarrhea, BD, HUS as well as from asymptomatic STEC-positive individuals in Sweden with whole-genome sequencing. We found that 173 out of 239 (72.4%) of clinical STEC strains were eae positive. Six eae subtypes (ϵ1, γ1, β3, θ, ζ and ρ) were identified eae and its subtype γ1 were significantly overrepresented in O157H7 strains isolated from BD and HUS patients. ϵ1 was associated with O121H19 and O103H2 strains, and β3 to O26H11 strains. The combination of eae subtype γ1 and stx subtype (stx2 or stx1+stx2) is more likely to cause severe disease, suggesting the possibility of using eae genotypes in risk assessment of STEC infection. In summary, this study demonstrated a high prevalence of eae in clinical STEC strains and considerable genetic diversity of eae in STEC strains in Sweden from 1994 through 2018, and revealed association between eae subtypes and disease severity.A multi-omics-based approach targeting the plant-based natural products from Thumbai (Leucas aspera), an important yet untapped potential source of many therapeutic agents for myriads of immunological conditions and genetic disorders, was conceptualized to reconnoiter its potential biomedical application. https://www.selleckchem.com/products/dn02.html A library of 79 compounds from this plant was created, out of which 9 compounds qualified the pharmacokinetics parameters. Reverse pharmacophore technique for target fishing of the screened compounds was executed through which renin receptor (ATP6AP2) and thymidylate kinase (DTYMK) were identified as potential targets. Network biology approaches were used to comprehend and validate the functional, biochemical and clinical relevance of the targets. The target-ligand interaction and subsequent stability parameters at molecular scale were investigated using multiple strategies including molecular modeling, pharmacophore approaches and molecular dynamics simulation. Herein, isololiolide and 4-hydroxy-2-methoxycinnamaldehyde were substantiated as the lead molecules exhibiting comparatively the best binding affinity against the two putative protein targets. These natural lead products from L. aspera and the combinatorial effects may have plausible medical applications in a wide variety of neurodegenerative, genetic and developmental disorders. The lead molecules also exhibit promising alternative in diagnostics and therapeutics through immuno-modulation targeting natural killer T-cell function in transplantation-related pathogenesis, autoimmune and other immunological disorders. Communicated by Ramaswamy H. Sarma.COVID-19, caused by novel coronavirus or SARS-CoV-2, is a viral disease which has infected millions worldwide. Considering the urgent need of the drug for fighting against this infectious disease, we have performed in-silico drug repurposing followed by molecular dynamics (MD) simulation and MM-GBSA calculation. The main protease (Mpro) is one of the best-characterized drug targets among coronaviruses, therefore, this was screened for already known FDA approved drugs and some natural compounds. Comparison of docking and MD simulation results of complexes of drugs with that of inhibitor N3 (experimentally obtained) suggests EGCG, withaferin, dolutegravir, artesunate as potential inhibitors of the main protease (Mpro). Further, in silico docking and MD simulation suggest that EGCG analogues ZINC21992196 and ZINC 169337541 may act as a better inhibitor. Communicated by Ramaswamy H. Sarma.

39 mins ago


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The platform incorporates a wide selection that involves classic table games such as blackjack, roulette, and baccarat, alongside a rich ...

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Videos

We recently shared a video of Dr. Ana Mihalcea’s microscopy videos which Ana says depict “self-assembling nanotechnology” in the blood of both vaccinated and unvaccinated people.

Some of you left very concerned comments on the post, asking us for additional sources with the same claims.

We didn’t actually set out to find any additional sources, BUT came upon some accidentally while clipping a segment from CHD’s recent Omniwar Symposium in collaboration with Catherine Austin Fitts.

So, here you go. And as always, please share with us links to information you think we should look into!

Here’s the full Omniwar Symposium (clipped segment begins around 44:27): https://x.com/i/broadcasts/1MnxnDzaaPMGO

09/13/2024

On this episode of Direct Impact, Rick Sanchez delves into the latest geopolitical developments and their far-reaching implications. With expert analysis from Ghadi Francis and Elijah Magnier, Sanchez explores Ukraine’s precarious position and the potential US authorization for Ukrainian missile strikes on Russian territory. The show also investigates the surprising celebrations in Jordan following an attack on Israeli soldiers and dissects the global reaction to Donald Trump’s controversial debate comments.

Have you ever considered that your food might have been injected with mRNA before importation to your country?

Dr. Sherri Tenpenny has.

Have any tips on sourcing locally-produced meat? Share in comments!

Circles

Sorry, no results were found.

Videos

We recently shared a video of Dr. Ana Mihalcea’s microscopy videos which Ana says depict “self-assembling nanotechnology” in the blood of both vaccinated and unvaccinated people.

Some of you left very concerned comments on the post, asking us for additional sources with the same claims.

We didn’t actually set out to find any additional sources, BUT came upon some accidentally while clipping a segment from CHD’s recent Omniwar Symposium in collaboration with Catherine Austin Fitts.

So, here you go. And as always, please share with us links to information you think we should look into!

Here’s the full Omniwar Symposium (clipped segment begins around 44:27): https://x.com/i/broadcasts/1MnxnDzaaPMGO

09/13/2024

On this episode of Direct Impact, Rick Sanchez delves into the latest geopolitical developments and their far-reaching implications. With expert analysis from Ghadi Francis and Elijah Magnier, Sanchez explores Ukraine’s precarious position and the potential US authorization for Ukrainian missile strikes on Russian territory. The show also investigates the surprising celebrations in Jordan following an attack on Israeli soldiers and dissects the global reaction to Donald Trump’s controversial debate comments.

Have you ever considered that your food might have been injected with mRNA before importation to your country?

Dr. Sherri Tenpenny has.

Have any tips on sourcing locally-produced meat? Share in comments!

08/21/2024

Elon Musk has confirmed that he would accept a cabinet position in a Trump administration, the title of which he has teased as “Director of Government Efficiency” (D.O.G.E.).

One of Musk’s first moves after acquiring Twitter was cutting the company’s workforce from 8,000 to about 1,500 employees.

Imagine what he could do in the government.

What do you think? Let us know in the comments!

07/15/2024

In today’s episode of Direct Impact, Rick Sanchez is joined by Dr. Wilmer Leon and Garland Nixon, co-hosts of ‘The Critical Hour’ on Radio Sputnik. Together they wrap up a week of topics from President Joe Biden’s repeated public stumbles and growing concerns over his physical and mental fitness. Rick also criticizes Biden’s recent comments that suggest a world leadership delusion, disrespecting global leaders forging new alliances. Additionally, the panel addresses media bias, showcasing a rare video of President Vladimir Putin with Indian Prime Minister Narendra Modi, and concludes with a spoof on Vice President Kamala Harris from Comedy Central.

Posts

17 mins ago


In the vast expanse of the internet, there exists a hidden realm often overlooked by the average user. This intriguing world is home to what are known as onion lists, a fascinating aspect of the deep web. While mainstream websites are easily accessible, https://virtuous-pear-mx5fx2.mystrikingly.com/blog/peeling-back-layers-the-ultimate-guide-to-onion-lists s offer a glimpse into a more anonymous and often mysterious digital landscape, showcasing a variety of content that can range from the benign to the controversial.

Onion lists are essentially directories of hidden services that utilize the Tor network, enabling users to explore websites that are not indexed by conventional search engines. These lists serve as gateways to a plethora of resources, communities, and information that are shielded from the prying eyes of the surface web. As we peel back the layers of onion lists, we uncover the myriad ways they influence privacy, security, and even activism on the internet, beckoning us to delve deeper into this unique and often enigmatic environment.

What are Onion Lists?

Onion lists are curated collections of links that provide access to various websites hosted on the dark web. These lists serve as a gateway for users who seek content that is not indexed by traditional search engines. The term 'onion' refers to the way in which these websites are accessed through the Tor network, where layers of encryption resemble the layers of an onion. This makes onion lists an essential resource for anyone looking to navigate the complex dark web landscape.

Typically, onion lists contain links that end with the .onion domain, which can only be reached using specific software like Tor. This unique domain structure ensures anonymity for both users and site operators, creating a space for a wide range of content, from the innocuous to the illegal. These lists may include forums, marketplaces, information sites, and much more, making them a diverse and sometimes controversial part of the internet.

Moreover, onion lists can vary significantly in terms of the content they host and the communities they serve. Some lists focus on specific themes, such as privacy advocacy or whistleblowing platforms, while others may aggregate links to various marketplaces that deal in goods and services that are often considered illicit. Understanding the nature of these lists is crucial for anyone interested in discovering the hidden corners of the internet, as they provide a glimpse into a world that operates outside the reach of mainstream online activity.



How Onion Lists are Used

Onion lists serve as crucial resources in the realm of online privacy and security. They organize and present a variety of websites and services that are accessible via the Tor network. Users seeking anonymity can consult these lists to find hidden services, such as forums, marketplaces, and whistleblowing platforms. By directing users to .onion sites, these lists promote a safer browsing experience, encouraging individuals to access content without compromising their identities.

Additionally, onion lists are instrumental for researchers and journalists who are investigating topics often shrouded in secrecy. With access to the right onion list, they can uncover valuable information and connect with sources that may not be available through conventional means. This aspect helps to shine a light on issues that may otherwise be neglected by mainstream media, contributing to a broader understanding of critical global matters.

Finally, onion lists facilitate discussions within communities that prioritize privacy and security. They often include user-generated ratings and comments, enabling users to evaluate the trustworthiness of various .onion sites. This collective knowledge fosters a more informed user base, helping individuals navigate the complexities of the deep web while minimizing risks associated with online activities.

The Future of Onion Lists

As the digital landscape continues to evolve, onion lists are likely to adapt and grow in complexity. With the increased focus on privacy and cybersecurity, more users may turn to these decentralized platforms for sharing and accessing information. Onion lists could expand beyond basic content sharing to include tools for enhanced anonymity and security, catering to those who prioritize their digital footprint. The merging of technology with privacy considerations may lead to innovative uses of onion lists, making them a staple in online interactions.

The role of onion lists could also be influenced by emerging regulations around data privacy. As governments implement stricter laws to protect user data, onion lists may serve as a refuge for those seeking to sidestep intrusive surveillance practices. This shift could encourage the development of more robust platforms that prioritize user control and data security. As a result, onion lists might not only provide anonymity but also create a safe space for free expression, fostering communities that challenge conventional norms.

Finally, the growth of decentralized technologies such as blockchain could revolutionize how onion lists are created and maintained. This integration could enhance transparency and trust among users while ensuring that the information shared remains untouchable by external forces. Moreover, as more individuals become aware of the risks associated with traditional internet usage, the reliance on onion lists may increase, ushering in an era of greater acceptance and innovation in these unique online spaces.


 Onion lists have become a crucial component of navigating the dark web, serving as directories that link to various hidden services and sites. These lists provide users with a way

virtuous-pear-mx5fx2.mystrikingly.com

19 mins ago


Only 25% of studies using matching reported calculating robust standard errors for the PS analyses.

The quality of reporting of PS methods in the MS literature is sub-optimal in general, and in some cases, inappropriate methods are used.
The quality of reporting of PS methods in the MS literature is sub-optimal in general, and in some cases, inappropriate methods are used.
Compassion meditation (CM) training has demonstrated potential in improving well-being and psychosocial functioning. However, most prior studies of CM training have focused on younger adults. The generalizability of the effectiveness of CM training with older adults requires further study. This pilot study was intended to inform future randomized controlled studies of CM training in older adults.

Participants included 24 older adults who attended a 10-week group CM training. Exploratory outcome measures were administered prior to, during, and after the intervention. Participants also completed logs of mood and meditation practice, and provided descriptive comments in response to open-ended questions administered at the end of treatment.

High treatment completion rates (87.5%) and reported adherence (85.7% of assigned meditation) were observed. Descriptive feedback from participants indicated older adults are interested in and capable of learning and applying new concepts and skills in support of their well-being. Pre- to post-intervention changes were explored with a variety of self-report measures. Weekly journals suggested increased feelings of love, closeness, or trust, and decreased feelings of stress, nervousness, or being overwhelmed.

These findings provide preliminary support for the feasibility of CM training in community-dwelling older adults, and suggest the need for future efficacy and effectiveness clinical trials.

CM training offers potential benefits for improving well-being among older adults, and, as an example of a strengths-based approach, can be tailored to the specific needs of older adults.
CM training offers potential benefits for improving well-being among older adults, and, as an example of a strengths-based approach, can be tailored to the specific needs of older adults.Tonsils are believed to be the initial site of the John Cunningham virus (JCV) infection. The long-term effect of childhood tonsillectomy on JCV status in multiple sclerosis (MS) patients has not been investigated. In this retrospective case-control study, we analyzed data of 144 JCV seropositive cases and 82 JCV seronegative controls from three outpatient MS clinics in the United States. Early tonsillectomy (before the age of 8) was reported among 8 (5.56%) JCV seropositive subjects and 19 (23.17%) controls. Early tonsillectomy was associated with JCV negative status (adjusted odds ratio = 5.39, 95% confidence interval = 2.13-13.62, p  less then  0.001) independent of age and gender.Shiga toxin (Stx)-producing Escherichia coli (STEC) can cause a wide range of symptoms from asymptomatic carriage, mild diarrhea to bloody diarrhea (BD) and hemolytic uremic syndrome (HUS). Intimin, encoded by the eae gene, also plays a critical role in STEC pathogenesis. Herein, we investigated the prevalence and genetic diversity of eae among clinical STEC isolates from patients with diarrhea, BD, HUS as well as from asymptomatic STEC-positive individuals in Sweden with whole-genome sequencing. We found that 173 out of 239 (72.4%) of clinical STEC strains were eae positive. Six eae subtypes (ϵ1, γ1, β3, θ, ζ and ρ) were identified eae and its subtype γ1 were significantly overrepresented in O157H7 strains isolated from BD and HUS patients. ϵ1 was associated with O121H19 and O103H2 strains, and β3 to O26H11 strains. The combination of eae subtype γ1 and stx subtype (stx2 or stx1+stx2) is more likely to cause severe disease, suggesting the possibility of using eae genotypes in risk assessment of STEC infection. In summary, this study demonstrated a high prevalence of eae in clinical STEC strains and considerable genetic diversity of eae in STEC strains in Sweden from 1994 through 2018, and revealed association between eae subtypes and disease severity.A multi-omics-based approach targeting the plant-based natural products from Thumbai (Leucas aspera), an important yet untapped potential source of many therapeutic agents for myriads of immunological conditions and genetic disorders, was conceptualized to reconnoiter its potential biomedical application. https://www.selleckchem.com/products/dn02.html A library of 79 compounds from this plant was created, out of which 9 compounds qualified the pharmacokinetics parameters. Reverse pharmacophore technique for target fishing of the screened compounds was executed through which renin receptor (ATP6AP2) and thymidylate kinase (DTYMK) were identified as potential targets. Network biology approaches were used to comprehend and validate the functional, biochemical and clinical relevance of the targets. The target-ligand interaction and subsequent stability parameters at molecular scale were investigated using multiple strategies including molecular modeling, pharmacophore approaches and molecular dynamics simulation. Herein, isololiolide and 4-hydroxy-2-methoxycinnamaldehyde were substantiated as the lead molecules exhibiting comparatively the best binding affinity against the two putative protein targets. These natural lead products from L. aspera and the combinatorial effects may have plausible medical applications in a wide variety of neurodegenerative, genetic and developmental disorders. The lead molecules also exhibit promising alternative in diagnostics and therapeutics through immuno-modulation targeting natural killer T-cell function in transplantation-related pathogenesis, autoimmune and other immunological disorders. Communicated by Ramaswamy H. Sarma.COVID-19, caused by novel coronavirus or SARS-CoV-2, is a viral disease which has infected millions worldwide. Considering the urgent need of the drug for fighting against this infectious disease, we have performed in-silico drug repurposing followed by molecular dynamics (MD) simulation and MM-GBSA calculation. The main protease (Mpro) is one of the best-characterized drug targets among coronaviruses, therefore, this was screened for already known FDA approved drugs and some natural compounds. Comparison of docking and MD simulation results of complexes of drugs with that of inhibitor N3 (experimentally obtained) suggests EGCG, withaferin, dolutegravir, artesunate as potential inhibitors of the main protease (Mpro). Further, in silico docking and MD simulation suggest that EGCG analogues ZINC21992196 and ZINC 169337541 may act as a better inhibitor. Communicated by Ramaswamy H. Sarma.

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estyle interventions for encouraging healthier behaviors, all are likely to be cost effective and appear to have positive effects on reproductive, maternal pregnancy, and birth outcomes. https://www.selleckchem.com/products/sn-001.html Further real-world data are required to determine the cost-effectiveness of pre-conception lifestyle interventions, including mobile apps and web-based tools that help improve lifestyle, and their effects on reproductive health. We believe that further implementation of the lifestyle app Smarter Pregnancy designed for subfertile couples seeking assistance to become pregnant is likely to be cost-effective and would allow reproductive health outcomes to be collected.
Individualized dietary and physical activity self-monitoring feedback is a core element of behavioral weight loss interventions and is associated with clinically significant weight loss. To our knowledge, no studies have evaluated individuals' perspectives on the composition of feedback messages or the effect of feedback composition on the motivation to self-monitor.

This study aims to assess the perceptions of feedback emails as a function of the number of comments that reinforce healthy behavior and the number of areas for change (ie, behavioral changes that the individual might make to have an impact on weight) identified.

Emailed feedback followed a factorial design with 2 factors (ie, reinforcing comments and areas for change), each with 3 levels (ie, 1, 4, or 8 comments). A total of 250 adults with overweight or obesity who were interested in weight loss were recruited from the Qualtrics research panel. Participants read 9 emails presented in a random order. For each email, respondents answered 8 self-monitor in the future.

The study findings suggest how feedback might be optimized for efficacy. Future studies should explore whether the composition of feedback email affects actual self-monitoring performance.
The study findings suggest how feedback might be optimized for efficacy. Future studies should explore whether the composition of feedback email affects actual self-monitoring performance.
Efforts are underway to semantically integrate large biomedical knowledge graphs using common upper-level ontologies to federate graph-oriented application programming interfaces (APIs) to the data. However, federation poses several challenges, including query routing to appropriate knowledge sources, generation and evaluation of answer subsets, semantic merger of those answer subsets, and visualization and exploration of results.

We aimed to develop an interactive environment for query, visualization, and deep exploration of federated knowledge graphs.

We developed a biomedical query language and web application interphase-termed as Translator Query Language (TranQL)-to query semantically federated knowledge graphs and explore query results. TranQL uses the Biolink data model as an upper-level biomedical ontology and an API standard that has been adopted by the Biomedical Data Translator Consortium to specify a protocol for expressing a query as a graph of Biolink data elements compiled from statementseved answers that we visualized and evaluated.

TranQL can be used to ask questions of relevance to translational science, rapidly obtain answers that require assertions from a federation of knowledge sources, and provide valuable insights for translational research and clinical practice.
TranQL can be used to ask questions of relevance to translational science, rapidly obtain answers that require assertions from a federation of knowledge sources, and provide valuable insights for translational research and clinical practice.
In the field of pain, virtual reality (VR) technology has been increasingly common in the context of procedural pain management. As an interactive technology tool, VR has the potential to be extended beyond acute pain management to chronic pain rehabilitation with a focus on increasing engagement with painful or avoided movements.

We outline the development and initial implementation of a VR program in pain rehabilitation intervention to enhance function in youth with chronic pain.

We present the development, acceptability, feasibility, and utility of an innovative VR program (Fruity Feet) for pediatric pain rehabilitation to facilitate increased upper and lower extremity engagement. The development team was an interdisciplinary group of pediatric experts, including physical therapists, occupational therapists, pain psychologists, anesthesiologists, pain researchers, and a VR software developer. We used a 4-phase iterative development process that engaged clinicians, parents, and patients via interviews qualitative feedback, questionnaires, and movement data. We discuss next steps for the refinement, implementation, and assessment of impact of VR on chronic pain rehabilitation. VR holds great promise as a tool to facilitate therapeutic gains in chronic pain rehabilitation in a manner that is highly reinforcing and fun.
The iterative development process yielded a highly engaging and feasible VR program based on qualitative feedback, questionnaires, and movement data. We discuss next steps for the refinement, implementation, and assessment of impact of VR on chronic pain rehabilitation. VR holds great promise as a tool to facilitate therapeutic gains in chronic pain rehabilitation in a manner that is highly reinforcing and fun.These personal views, drawn from the experiences of a medical student and a medical school lecturer, advocate caution of the current trend for formal adoption of peer teaching into medical school curricula. Using a metaphor from physics, we highlight the need for cautious deeper exploration of the informal world of peer-teaching in medical schools, which is a complex part of the educational ecosystem, prior to incorporating such activities into faculty-led initiatives. We support a measured approach to the introduction of compulsory peer-teaching activities given the recognized theoretical and pedagogical benefits.Sense of coherence (SoC) is the origin of health according to Antonovsky. The link between SoC and risk of cancer has however rarely been assessed. We performed a cohort study of 46,436 women from the Karolinska Mammography Project for Risk Prediction of Breast Cancer (Karma). Participants answered a SoC-13 questionnaire at recruitment to Karma and were subsequently followed up for incident breast cancer. Multivariate Cox models were used to assess the hazard ratios (HRs) of breast cancer in relation to SoC. We identified 771 incident cases of breast cancer during follow-up (median time 5.2 years). No association was found between SoC, either as a categorical (strong vs. weak SoC, HR 1.08, 95% CI 0.90-1.29) or continuous (HR 1.08; 95% CI 1.00-1.17 per standard deviation increase of SoC) variable, and risk of breast cancer. In summary, we found little evidence to support an association between SoC and risk of breast cancer.

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