Active involvement of patients in planning, conducting, and disseminating research has been adopted by many organisations internationally, but the extent to which this occurs in surgical wound care is not evident. This scoping review aimed to identify how patients have been involved in surgical wound care research and the quality of its reporting. Full-text studies focused on preoperative and postoperative surgical wound care in the acute care setting, published in English between 2004 and 2019, were included in the review. Screening, data charting, and quality assessment were conducted by two reviewers independently, adjudicated by a third, and then reviewed by five others. Thematic analysis synthesised the findings. Of the eight included studies, seven explained the methods for patient involvement and five described aims related to patient involvement and commented on patient involvement in the discussion. None met all of the quality assessment criteria. Three themes emerged involvement in modifying and refining research processes, connecting and balancing expert and patient views, and sharing personal insights. Recommendations to improve patient involvement in surgical wounds research include the following using framework and tools to inform future research; training researcher and patients in their respective research roles; and ongoing monitoring of patient involvement.To revitalize nursing science, there is a need for a new approach to guide nurse scientists in addressing complex problems in health care. By applying theoretical concepts from a revolutionary philosopher of science, Paul K. Feyerabend, new nursing knowledge can be produced using creativity and pluralistic approaches. Feyerabend proposed that methods within and outside of science can produce knowledge. Despite the recognition of Feyerabendian philosophy within science, there is currently a lack of literature regarding the relevance of Feyerabendian philosophy for nursing science. We aim to (a) describe and critique Feyerabendian concepts, (b) discuss the potential application of Feyerabendian philosophy for knowledge production within gerontological nursing and (c) describe theoretical possibilities for nurse scientists in using Feyerabendian philosophy to guide nursing knowledge development. We begin by introducing Feyerabend's life and his inspirations for his theoretical concepts, epistemological anarchism, theoretical pluralism and humanitarianism, and conclude by offering suggestions of how to apply Feyerabendian philosophy in nursing research.It is well recognized that cancer drug development for children and adolescents has many challenges, from biological and societal to economic. Pediatric cancer consists of a diverse group of rare diseases, and the relatively small population of children with multiple, disparate tumor types across various age groups presents a significant challenge for drug development programs as compared to oncology drug development programs for adults. Due to the different types of cancers, limited opportunities exist for extrapolation of efficacy from adult cancer indications to children. Thus, innovative study designs including Bayesian statistical approaches should be considered. A Bayesian approach can be a flexible tool to formally leverage prior knowledge of adult or external controls in pediatric cancer trials. In this article, we provide in a case example of how Bayesian approaches can be used to design, monitor, and analyze pediatric trials. Particularly, Bayesian sequential monitoring can be useful to monitor pediatric trial results as data accumulate. In addition, designing a pediatric trial with both skeptical and enthusiastic priors with Bayesian sequential monitoring can be an efficient mechanism for early trial cessation for both efficacy and futility. The interpretation of efficacy using a Bayesian approach is based on posterior probability and is intuitive and interpretable for patients, parents and prescribers given limited data.The nuclear lamina is essential for the structural integration of the nuclear envelope. Nuclear envelope rupture and chromatin externalization is a hallmark of the formation of neutrophil extracellular traps (NETs). https://www.selleckchem.com/products/muramyl-dipeptide.html NET release was described as a cellular lysis process; however, this notion has been questioned recently. Here, we report that during NET formation, nuclear lamin B is not fragmented by destructive proteolysis, but rather disassembled into intact full-length molecules. Furthermore, we demonstrate that nuclear translocation of PKCα, which serves as the kinase to induce lamin B phosphorylation and disassembly, results in nuclear envelope rupture. Decreasing lamin B phosphorylation by PKCα inhibition, genetic deletion, or by mutating the PKCα consensus sites on lamin B attenuates extracellular trap formation. In addition, strengthening the nuclear envelope by lamin B overexpression attenuates NET release in vivo and reduces levels of NET-associated inflammatory cytokines in UVB-irradiated skin of lamin B transgenic mice. Our findings advance the mechanistic understanding of NET formation by showing that PKCα-mediated lamin B phosphorylation drives nuclear envelope rupture for chromatin release in neutrophils.The natural history of Crohn's disease (CD) usually begins with primary intestinal inflammation, which progresses gradually to stricturing lesions. Stricture is a complicated, intractable but very common clinical problem in the management of CD. Difficulties remain in treating stricturing CD because of the limited efficacy of drug therapy and relapse of stricturing lesions cannot be completely avoided by surgery. Endoscopic management is a bridging therapy between drug therapy and surgical intervention, mainly including endoscopic balloon dilatation and endoscopic stricturotomy, and has been found to be effective for treating stricturing CD. Its explicit curative effect, less invasiveness and high safety performance make endoscopic management more acceptable by both the physician and patient. Although some patients require repeated endoscopic treatment and ultimately cannot avoid surgery, yet it can significantly delay the time to surgery and improve the quality of life. Physicians carrying out the endoscopic procedure need to be trained for performing this procedure.

Top 10 Hollywood Thriller Movies: A Gripping Collection of Suspense

Thriller movies are renowned for their ability to grip audiences with intense, edge-of-your-seat action, intricate plots, and psychological twists. Hollywood has produced some of the finest thrillers, blending elements of suspense, mystery, and drama to keep viewers guessing until the very end. Whether you're a fan of psychological tension, gripping narratives, or fast-paced action, here’s a look at the top 10 Hollywood thriller movies that have defined the genre.

1. Se7en (1995)
Director: David Fincher
Cast: Brad Pitt, Morgan Freeman, Kevin Spacey

In this dark psychological thriller, two detectives—young and impulsive Mills (Brad Pitt) and seasoned veteran Somerset (Morgan Freeman)—investigate a series of murders inspired by the seven deadly sins. David Fincher’s Se7en masterfully builds tension, leading to one of the most unforgettable and disturbing endings in thriller history. The film's exploration of morality and evil, combined with strong performances, makes it a benchmark for psychological suspense.

2. The Silence of the Lambs (1991)
Director: Jonathan Demme
Cast: Jodie Foster, Anthony Hopkins

A classic thriller that introduced one of cinema’s most terrifying characters, Dr. Hannibal Lecter (Anthony Hopkins), The Silence of the Lambs follows FBI trainee Clarice Starling (Jodie Foster) as she seeks Lecter’s help in capturing another serial killer, Buffalo Bill. The tense psychological cat-and-mouse game between Clarice and Lecter makes for gripping cinema. Anthony Hopkins’ performance earned him an Academy Award, and the film remains one of the most celebrated thrillers of all time.

3. Inception (2010)
Director: Christopher Nolan
Cast: Leonardo DiCaprio, Joseph Gordon-Levitt, Tom Hardy

Inception is a mind-bending sci-fi thriller that takes the audience into the realm of dreams. Dom Cobb (Leonardo DiCaprio) is a skilled thief specializing in extracting secrets from within the subconscious. When tasked with planting an idea in someone’s mind, Cobb must navigate multiple layers of dreams, which creates an intense and disorienting experience for both characters and viewers. Nolan’s direction and the film's layered narrative structure make Inception one of the most thought-provoking and suspenseful thrillers in recent memory.

4. Shutter Island (2010)
Director: Martin Scorsese
Cast: Leonardo DiCaprio, Mark Ruffalo, Ben Kingsley

Based on Dennis Lehane’s novel, Shutter Island follows U.S. Marshal Teddy Daniels (Leonardo DiCaprio) as he investigates the disappearance of a patient at a mental institution. As Daniels delves deeper into the mysteries of the island, the lines between reality and madness blur, leading to a shocking twist. Martin Scorsese’s atmospheric direction, combined with DiCaprio’s powerful performance, makes this a thriller that keeps viewers guessing until the very last frame.

5. Gone Girl (2014)
Director: David Fincher
Cast: Ben Affleck, Rosamund Pike

Adapted from Gillian Flynn’s best-selling novel, Gone Girl explores the dark side of marriage. When Nick Dunne (Ben Affleck) becomes the prime suspect in the mysterious disappearance of his wife Amy (Rosamund Pike), a media circus ensues, and hidden secrets start to unravel. David Fincher's expert direction and Rosamund Pike’s chilling portrayal of Amy make Gone Girl a tense and twist-filled psychological thriller that leaves audiences questioning every character’s motives.

6. The Sixth Sense (1999)
Director: M. Night Shyamalan
Cast: Bruce Willis, Haley Joel Osment

In this supernatural thriller, child psychologist Dr. Malcolm Crowe (Bruce Willis) treats a young boy, Cole (Haley Joel Osment), who claims he can see dead people. As Crowe helps the boy confront his fears, the film builds to one of the most iconic plot twists in film history. The Sixth Sense is a slow-burn thriller that delves into themes of loss, trauma, and redemption, with Osment’s performance as the haunted child giving the film a powerful emotional core.

7. The Girl with the Dragon Tattoo (2011)
Director: David Fincher
Cast: Daniel Craig, Rooney Mara

Another David Fincher thriller, The Girl with the Dragon Tattoo is a gripping adaptation of Stieg Larsson’s popular novel. The film follows journalist Mikael Blomkvist (Daniel Craig) and hacker Lisbeth Salander (Rooney Mara) as they investigate a decades-old mystery involving a powerful family. Rooney Mara’s portrayal of the brilliant yet troubled Lisbeth Salander earned her critical acclaim, and Fincher’s direction ensures that the film’s tense and dark narrative keeps viewers enthralled from beginning to end.

8. Prisoners (2013)
Director: Denis Villeneuve
Cast: Hugh Jackman, Jake Gyllenhaal, Viola Davis

Prisoners is a gritty, emotional thriller about a father's desperate search for his missing daughter. When two young girls disappear, their families and a relentless detective (Jake Gyllenhaal) are drawn into a complex investigation that reveals unsettling secrets. Hugh Jackman delivers a raw, powerful performance as a father willing to go to any lengths to find his child. Denis Villeneuve's direction keeps the suspense at a high level throughout the film, making it an intense viewing experience.

9. No Country for Old Men (2007)
Directors: Joel and Ethan Coen
Cast: Tommy Lee Jones, Javier Bardem, Josh Brolin

In this dark, atmospheric thriller, Llewelyn Moss (Josh Brolin) stumbles upon a briefcase of cash left after a drug deal gone wrong, which sets off a deadly pursuit by a remorseless hitman, Anton Chigurh (Javier Bardem). The Coen Brothers' No Country for Old Men is a slow-burn thriller that masterfully builds tension through its stark landscapes and minimalist dialogue. Bardem’s portrayal of Chigurh, one of cinema’s most chilling villains, and the film’s exploration of fate and morality make it an unforgettable entry in the thriller genre.

10. Fight Club (1999)
Director: David Fincher
Cast: Brad Pitt, Edward Norton, Helena Bonham Carter

Fight Club is a psychological thriller that follows an unnamed narrator (Edward Norton) as he forms an underground fight club with the charismatic Tyler Durden (Brad Pitt). What begins as a rebellion against consumer culture quickly spirals into something much darker. The film explores themes of identity, masculinity, and anarchism. Its shocking plot twists and intense performances make it a must-see for thriller fans. Fight Club is not only a gripping thriller but also a thought-provoking commentary on modern society.

Conclusion
Hollywood thrillers captivate audiences by combining psychological depth, unexpected plot twists, and fast-paced action. From David Fincher’s dark explorations of human nature in Se7en and Gone Girl to Christopher Nolan’s mind-bending narrative in Inception, these films push the boundaries of the thriller genre. Whether it’s the raw tension of Prisoners or the unsettling atmosphere of Shutter Island, each of these top 10 thrillers offers a unique and unforgettable cinematic experience, keeping viewers glued to their screens and questioning every twist and turn.
IF YOU ARE INTERESTED TO WATCH FREE MOVIES VISIT LINK : https://fmovies.us/

To revitalize nursing science, there is a need for a new approach to guide nurse scientists in addressing complex problems in health care. By applying theoretical concepts from a revolutionary philosopher of science, Paul K. Feyerabend, new nursing knowledge can be produced using creativity and pluralistic approaches. Feyerabend proposed that methods within and outside of science can produce knowledge. Despite the recognition of Feyerabendian philosophy within science, there is currently a lack of literature regarding the relevance of Feyerabendian philosophy for nursing science. We aim to (a) describe and critique Feyerabendian concepts, (b) discuss the potential application of Feyerabendian philosophy for knowledge production within gerontological nursing and (c) describe theoretical possibilities for nurse scientists in using Feyerabendian philosophy to guide nursing knowledge development. We begin by introducing Feyerabend's life and his inspirations for his theoretical concepts, epistemological anarchism, theoretical pluralism and humanitarianism, and conclude by offering suggestions of how to apply Feyerabendian philosophy in nursing research.It is well recognized that cancer drug development for children and adolescents has many challenges, from biological and societal to economic. Pediatric cancer consists of a diverse group of rare diseases, and the relatively small population of children with multiple, disparate tumor types across various age groups presents a significant challenge for drug development programs as compared to oncology drug development programs for adults. Due to the different types of cancers, limited opportunities exist for extrapolation of efficacy from adult cancer indications to children. Thus, innovative study designs including Bayesian statistical approaches should be considered. A Bayesian approach can be a flexible tool to formally leverage prior knowledge of adult or external controls in pediatric cancer trials. In this article, we provide in a case example of how Bayesian approaches can be used to design, monitor, and analyze pediatric trials. Particularly, Bayesian sequential monitoring can be useful to monitor pediatric trial results as data accumulate. In addition, designing a pediatric trial with both skeptical and enthusiastic priors with Bayesian sequential monitoring can be an efficient mechanism for early trial cessation for both efficacy and futility. The interpretation of efficacy using a Bayesian approach is based on posterior probability and is intuitive and interpretable for patients, parents and prescribers given limited data.The nuclear lamina is essential for the structural integration of the nuclear envelope. Nuclear envelope rupture and chromatin externalization is a hallmark of the formation of neutrophil extracellular traps (NETs). NET release was described as a cellular lysis process; however, this notion has been questioned recently. Here, we report that during NET formation, nuclear lamin B is not fragmented by destructive proteolysis, but rather disassembled into intact full-length molecules. Furthermore, we demonstrate that nuclear translocation of PKCα, which serves as the kinase to induce lamin B phosphorylation and disassembly, results in nuclear envelope rupture. Decreasing lamin B phosphorylation by PKCα inhibition, genetic deletion, or by mutating the PKCα consensus sites on lamin B attenuates extracellular trap formation. In addition, strengthening the nuclear envelope by lamin B overexpression attenuates NET release in vivo and reduces levels of NET-associated inflammatory cytokines in UVB-irradiated skin of lamin B transgenic mice. Our findings advance the mechanistic understanding of NET formation by showing that PKCα-mediated lamin B phosphorylation drives nuclear envelope rupture for chromatin release in neutrophils.The natural history of Crohn's disease (CD) usually begins with primary intestinal inflammation, which progresses gradually to stricturing lesions. Stricture is a complicated, intractable but very common clinical problem in the management of CD. Difficulties remain in treating stricturing CD because of the limited efficacy of drug therapy and relapse of stricturing lesions cannot be completely avoided by surgery. Endoscopic management is a bridging therapy between drug therapy and surgical intervention, mainly including endoscopic balloon dilatation and endoscopic stricturotomy, and has been found to be effective for treating stricturing CD. Its explicit curative effect, less invasiveness and high safety performance make endoscopic management more acceptable by both the physician and patient. Although some patients require repeated endoscopic treatment and ultimately cannot avoid surgery, yet it can significantly delay the time to surgery and improve the quality of life. Physicians carrying out the endoscopic procedure need to be trained for performing this procedure. In this review we summarized the diagnosis and endoscopic treatment of stricturing CD. This article is protected by copyright. All rights reserved.The assurance method is growing in popularity in clinical trial planning. The method involves eliciting a prior distribution for the treatment effect, and then calculating the probability that a proposed trial will produce a "successful" outcome. For normally distributed observations, uncertainty about the variance of the normal distribution also needs to be accounted for, but there is little guidance in the literature on how to elicit a distribution for a variance parameter. We present a simple elicitation method, and illustrate how the elicited distribution is incorporated within an assurance calculation. We also consider multi-stage trials, where a decision to proceed with a larger trial will follow from the outcome of a smaller trial; we illustrate the role of the elicited distribution in assessing the information provided by a proposed smaller trial. Free software is available for implementing our methods.Background To assess the influence of ridge preservation procedures on the healing of extraction sockets under antiresorptive therapy. Material and methods A total of 10 Dutch Belted rabbits were randomly allocated to either the intravenous administration of amino-bisphosphonate (zoledronic acid) (Za) (n = 5) or a negative control group (no Za [nZa]) (n = 5). At 6 months, the mandibular and maxillary molars were extracted and the four experimental sites randomly allocated to the following subgroups (a) socket grafting using a collagen-coated natural bone mineral (BOC) + primary wound closure, (b) coronectomy (CO), or (c) spontaneous healing + primary wound closure (SP). Za medication was continued for another 4 months. Histomorphometrical analyses considered, for example, crestal hard tissue closure of the extraction site (C) and mineralized tissue (MT) formation. Results Za-SP was associated with an incomplete median C (31.76% vs 100% in nZa-SP) and signs of bone arrosion along the confines of the socket. BOC had no major effects on increases in C and MT values in the Za group. CO commonly resulted in an encapsulation and partial replacement resorption of residual roots by MT without any histological signs of osteonecrosis. Conclusions (a) Za-SP was commonly associated with a compromised socket healing and signs of osteonecrosis, (b) BOC had no major effect on socket healing in the Za group, and (c) CO at noninfected teeth might be a feasible measure for the prevention of a Za-related osteonecrosis of the jaw.Formaldehyde (FA) is endogenously produced in living systems through a variety of biological processes, and has been implicated in many pathological conditions. Detection tools for biological FA are, therefore, of great interest. Here we report novel activity-based genetically encoded fluorescent and luminescent probes for detecting FA in aqueous solutions and living mammalian cells. A FA-reactive lysine analogue, PrAK, was site-specifically incorporated into the essential lysine sites of enhanced green fluorescent protein (EGFP) and firefly luciferase (fLuc) to afford the fluorescent and luminescent probes, respectively. FA selectively reacts with the PrAK residues on EGFP and fLuc through 2-aza-Cope rearrangement, resulting in fluorescence and luminescence turn-on responses, respectively, to FA over potentially interfering reactive species in aqueous buffer. Moreover, the genetically encoded probes are capable of visualizing FA at physiologically relevant levels in living mammalian cells by fluorescence and luminescence imaging, demonstrating their potential as new tools to explore FA biology.The outstanding adhesive performance of mussel byssal threads has been a beacon of inspiration for materials scientists over the past few decades. https://www.selleckchem.com/products/danicopan.html Historically, presence of a significant amount of the unique catecholic amino acid dihydroxyphenylalanine (Dopa) has been considered to play a key role in strong dry and wet adhesive properties of the byssal interfacial proteins. In recent years, molecular and microscopic level studies using short peptides or small molecule analogs have investigated the roles of other amino acids in mussel adhesion. In particular, these studies have highlighted the cohesive role of cation-π interactions as well as the adhesive synergy between Dopa and flanking lysine residues. Inspired to design advanced synthetic adhesives that exploit amino-catechol synergy, we synthesized polymeric pressure sensitive adhesives (PSAs) by copolymerizing traditional PSA monomers, butyl acrylate and acrylic acid, with mussel-inspired lysine- and aromatic-rich monomers. Of particular interest was to compare the consequences of decoupling amino and catechol moieties from each other (i.e. incorporated as separate monomers) versus a monomer architecture in which the catechol and amine were coupled together in a fixed orientation in the monomer side chain. Comprehensive multi-scale adhesion assays were used to probe performance at the molecular, microscopic and macroscopic levels through a combination of AFM-assisted force spectroscopy, peel and static shear adhesion. We showed that coupling of catechols and amines together within the same monomer side chain produced optimal cooperative effects in improving macroscopic adhesion performance. The findings in this study improve our understanding of underlying principles of mussel adhesion and provide a solid framework for rational design of high-performance bioinspired adhesives.Background Low-grade gliomas (LGGs) are primary diffuse slow-growing brain tumors derived from glial cells. The management of these tumors is dependent on their location, which often harbors eloquent areas. We retrospectively recorded the location of diffuse gliomas to identify whether specific differences exist between the histological types. Methods We analyzed 102 patients with previous histological diagnosis of WHO-II astrocytomas (62) and WHO-II oligodendrogliomas (40) according to WHO-2016 classification. MRI sequences (T2-FLAIR) were used for tumor volume segmentation and to create a frequency map of their locations within the Montreal Neurological Institute (MNI) space. The Brain-Grid (BG) system (standardized radiological tool of intersected lines according to anatomical landmarks) was created and merged with a tractography atlas for infiltration analysis. Results Astrocytomas frequently infiltrated association and projection white matter pathways within fronto-temporo-insular regions on the left side.

Maybe anarchism shouldn't have such a negative connotation. Agree?

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I recently had a blast on the 'Far Out With Faust Podcast' discussing the information war, anarchism, police accountability, election integrity, and how to ride the white pill of optimism.

Watch Here: https://www.youtube.com/watch?v=rk-UNM1QgPg