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Inferring gestational age from this routine clinical phenotyping data could be useful in resource limited settings which lack obstetric ultrasound. Overall, both the cellular and proteomic analyses validate previously reported phenotypic immunological changes of pregnancy, and uncover new alternations and predictive markers.In patients with HBV and HCV coinfection, HBV reactivation leading to severe hepatitis has been reported with the use of direct-acting antivirals (DAAs) to treat HCV infection. Here we study the molecular mechanisms behind this viral interaction. In coinfected cell culture and humanized mice, HBV replication was suppressed by HCV coinfection. In vitro, HBV suppression was attenuated when interferon signaling was blocked. In vivo, HBV viremia, after initial suppression by HCV super-infection, rebounded following HCV clearance by DAA treatment that was accompanied by a reduced hepatic interferon response. Using blood samples of coinfected patients, interferon-stimulated gene products including C-X-C motif chemokine 10 (CXCL10) and C-C motif chemokine ligand 5 (CCL5), and alanine aminotransferase (ALT) were identified to have predictive value for HBV reactivation after HCV clearance. Taken together, our data suggest that HBV reactivation is a result of diminished hepatic interferon response following HCV clearance and identifies serologic markers that can predict HBV reactivation in DAA-treated HBV-HCV coinfected persons.BACKGROUNDSeizure-induced inhibition of respiration plays a critical role in sudden unexpected death in epilepsy (SUDEP). However, the mechanisms underlying seizure-induced central apnea in pediatric epilepsy are unknown.METHODSWe studied 8 pediatric patients with intractable epilepsy undergoing intracranial electroencephalography. We recorded respiration during seizures and during electrical stimulation mapping of 174 forebrain sites. A machine-learning algorithm was used to delineate brain regions that inhibit respiration.RESULTSIn 2 patients, apnea coincided with seizure spread to the amygdala. Supporting a role for the amygdala in breathing inhibition in children, electrically stimulating the amygdala produced apnea in all 8 subjects (3-17 years old). These effects did not depend on epilepsy type and were relatively specific to the amygdala, as no other site affected breathing. Remarkably, patients were unaware that they had stopped breathing, and none reported dyspnea or arousal, findings critical for SUDEP. Finally, a machine-learning algorithm based on 45 stimulation sites and 210 stimulation trials identified a focal subregion in the human amygdala that consistently produced apnea. This site, which we refer to as the amygdala inhibition of respiration (AIR) site includes the medial subregion of the basal nuclei, cortical and medial nuclei, amygdala transition areas, and intercalated neurons.CONCLUSIONSA focal site in the amygdala inhibits respiration and induces apnea (AIR site) when electrically stimulated and during seizures in children with epilepsy. This site may prove valuable for determining those at greatest risk for SUDEP and as a therapeutic target.FUNDINGNational Institute of Neurological Disorders and Stroke - Congress of Neurological Surgeons, National Institute of General Medical Sciences, Roy J. Carver Charitable Trust.Bromodomain-containing protein 4 (BRD4) is overexpressed in thyroid carcinoma, represents as an important therapeutic target. ARV-825 is a novel cereblon-based PROTAC (Proteolysis Targeting Chsimera) compound. It can induce fast and sustained BRD4 protein degradation. Its potential effect in human thyroid carcinoma cells was studied here. In TPC-1 cells and primary human thyroid carcinoma cells, ARV-825 potently inhibited cell viability, proliferation and migration. Furthermore, ARV-825 induced robust apoptosis activation in the thyroid carcinoma cells. ARV-825 induced BRD4 protein degradation and downregulation of its targets, including c-Myc, Bcl-xL and cyclin D1 in thyroid carcinoma cells. It was significantly more potent in inhibiting thyroid carcinoma cells than the known small molecule BRD4 inhibitors. In vivo studies demonstrated that ARV-825 oral administration potently suppressed TPC-1 xenograft tumor growth in severe combined immunodeficient mice. BRD4 protein degradation as well as c-Myc, Bcl-xL and cyclin D1 downregulation were detected in ARV-825-treated TPC-1 tumor tissues. Taken together, ARV-825 induces BRD4 protein degradation and inhibits thyroid carcinoma cell growth in vitro and in vivo.BACKGROUND In recent decades, long non-coding RNAs (lncRNAs) have been reported as crucial functional regulators involved in ovarian cancer. In the present study, we explored how lncRNA RHPN1-AS1 influences the progression of epithelial ovarian cancer (EOC) through tumor cell-dependent mechanisms. RESULTS The expression of RHPN1-AS1 in EOC tissues was higher than that in para-cancerous control tissues. High expression of RHPN1-AS1 was closely associated with poor prognosis in EOC patients. https://www.selleckchem.com/ N6-methyladenosine (m6A) improved the stability of RHPN1-AS1 methylation transcript by reducing RNA degradation, which resulted in upregulation of RHPN1-AS1 in EOC. In vitro and in vivo functional experiments showed that RHPN1-AS1 promoted EOC cell proliferation and metastasis. RHPN1-AS1 acted as a ceRNA to sponge miR-596, consequently increasing LETM1 expression and activating the FAK/PI3K/Akt signaling pathway. CONCLUSION RHPN1-AS1-miR-596-LETM1 axis plays a crucial role in EOC progression. Our findings may provide promising drug targets for EOC treatment. METHODS We determined the aberrantly expressed lncRNAs in EOC via microarray analysis and validated RHPN1-AS1 expression by qRT-PCR. The RHPN1-AS1-miR-596-LETM1 axis was examined by dual-luciferase reporter assay and RIP assay. The mechanism of RHPN1-AS1 was investigated through gain- and loss-of-function studies both in vivo and in vitro.BACKGROUND Social media use continues to gain momentum in academic neurosurgery. To increase journal impact and engage more broadly, many journals have turned to social media to disseminate research. The Journal of Neurosurgery Publishing Group (JNSPG) established a dedicated, specialized social media team (SMT) in November 2016 to provide targeted improvement in digital outreach. OBJECTIVE The goal of this study was to examine the impact of the JNSPG social media team as measured by increased engagement. METHODS This study analyzes metrics, including impressions, engagements, retweets, likes, profile clicks, and URL clicks, from consecutive social media posts from the JNSPG's Twitter and Facebook platforms between 2/1/2015 and 2/28/2019. Standard descriptive statistics were utilized. RESULTS Between February 2015 and October 2016, when a specialized SMT was created, 170 tweets (8.1 tweets/month) were posted compared to 3,220 tweets (115.0 tweets/month) between November 2016 and February 2019. All metrics significantly increased, including the impressions per tweet (1,646.

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8 mins ago


Masturbators are designed to simulate the sensation of vaginal, anal, or oral intercourse and can provide intense pleasure. They're available in a wide variety of styles, including pocket pussies, sleeves, or realistic molded replicas of body parts. For more advice, seek online help from one of the more reputable sites, such as goodvibes.com, loverspackage.com or evesgarden.com. Various iterations of the vibrator, now available in battery-powered or plugged-in models, have been around since the late 19th century. By directly stimulating the nerves, the device helps activate those that are not responding to the usual methods of arousal.

But that’s just one of the many masturbation sleeves available for purchase. There’s also the Hot Octopuss Pulse Duo, which can be used with a partner with a vulva for a hot shared experience. Dubbed the first “Guybrator,” this toy wraps around the penis and jacks it off using oscillation (or more specifically, something called “PulsePlate Technology”). Originally, they were designed to help vulva owners strengthen their pelvic floor muscles. Others, like the Zalo Desire preheating thruster, are shaped like standard dildos.

For this article, I picked the cream of the crop in the $150-plus range, and also asked some experts about their fave high-end toys to round out the story. The soft silicone of this ring feels luxurious to the touch, and its variety of settings and speeds are fun to experiment with. Another form of sex toys for both men and women are those for erotic electrostimulation. Erotic electrostimulation refers to the act of using electricity for sexual stimulation. By the mid-1970s, medical transcutaneous electrical nerve stimulation (TENS) machines were widely available. The machines work by stimulating nerve endings with electricity, sending signals of stimulation to the brain.

Introducing the PULSE QUEEN, the world’s first wand with PulsePlate Technology™. Setting a new standard for wands everywhere, the PULSE QUEEN delivers high-amplitude oscillations that penetrate deep into your body. Whether you’re a newbie or a power queen, the PULSE QUEEN will have you accessing a whole new orgasm pallet you never knew existed. A stunning, iridescent special edition of our best-selling toy for penis owners, PULSE DRAGON EYE is so sexy to look at, you'll get as much pleasure owning it as using it…well, almost. Sexual activity can provide some assistance with each of these. It can help pass the time, at least a minute for some, longer for others.

You can use the Osci 2 for up to five hours after a 105-minute charge, which is one of the longest-lasting batteries on this list. The app also lets you share the controls with a partner for long-distance play. Measuring just about the size of a tube of lipstick (and looking just like one, too), this precision-point bullet vibe from Vush is legit the epitome of discretion. It's also got 10 vibration settings, easy single-button operation, and a handy magnetic charging case allows you to simply toss it in your bag. Welcome to a realm of empowerment and discovery, where sexual health and wellness take center stage.

The choice of this high-grade material provides safety in use and the option to heat or chill the toys. Borosilicate glass is also non-porous and can be sterilized to help prevent infection with reuse. The highest quality glass toys can even be put in the dishwasher making them easier to keep clean.

Prolong your pleasure with this silicone C-ring that’s easy to slide on and off. Shop for yourself or a partner and pick from our textured sleeves and crush-worthy products. The truth is, straps have been around since time immemorial – literally. The first historical documentation of a strap-on was during the Upper Palaeolithic period, (a.k.a the Stone Age), about 30,000 years ago. And, in sapphic relationships, they’ve long signified power exchanges, pleasure and, sometimes – but not always, masculine energy. Silicone is non-porous and can be sanitized and disinfected with a toy cleaner, rubbing alcohol, boiling, or dishwashing.

Additionally, the team evaluated thousands of customer reviews and ratings to narrow down the best couples sex toys for a wide range of needs and preferences. Nu Sensuelle offers a wide range of pleasure products and sex toys including bullets, vibrators, anal toys, penis rings, and more. Nu Sensuelle's products are catered towards couples and users of every body type, gender, and sexual orientation, as inclusivity, intimacy and experimentation are at the heart of our core values. The stylishly packaged, versatile and innovative sex toys are backed with the stability of engineering and the guarantee of impeccable customer service. Our sex toys for men are available at a number of different price points. With that being said, don't be afraid to try out a few options of our best sex toys.

A nerdy twist on your average dildos, vibrators and butt plugs!! Tentacle toys, Dragon dildos and Alien appendages, we’ve got the perfect toys to satisfy all your naughty nerdy fantasies. Join us on the socials and tell us which geeky creation you want to see next. Delve into the world of pleasure and intimacy with Honey Birdette's collection of luxury sex toys and vibrators. Ultimate opulence awaits with our sex toys for men, sex toys for women, or indulge your lover with vibrators and sex toys for couples. Vibrators and sex toys designed with pleasure in mind are crafted with high-quality silicone and gold hardware, ensuring they hit the right spot.

Whether it’s finding great products or discovering helpful advice, we’ll help you get it right (the first time). We chose not to test the since-discontinued Unbound Squish because it appeared to be very similar to the Minna Limon, which also offers programmable stimulation and squeeze-pressure technology. Our tester who tried Minna’s similar Ola toy (currently unavailable) found this technology to be more gimmicky than innovative. We tried the 6, which is similar in shape and size to a fountain pen.

Indulge in luxury with the LELO Bundle, featuring the TIANI Duo Blue Dual-Action Couple’s Massager, TOR 2 Black Couple’s Ring, and LELO Personal Moisturizer. Elevate your intimate moments with premium materials, sophisticated design, and unrivaled performance for an unforgettable experience. Free shipping label for eligible returns and a one-year warranty for all Pepper products.

Le Wand makes some of the best wand vibrators on the market, and they’re typically priced pretty high because of that. This one comes decked out with art from illustrator Kelly Malka and still features everything we love about Le Wand vibrators. We recently reviewed the Die Cast version (8/10 WIRED Recommends) and came away very impressed.

Earplugs can be great for BDSM sensory play as a way to help build arousal, anticipation, and even mystery during sex. If https://www.wholesale-sex-toys.com/ ’re both into consensual BDSM and sense play, you can couple this with a blindfold or sleep mask, tie your partner up, and put the earplugs in. Speaking of what's in your kitchen, let's not forget the many ways you can incorporate food into your sex life. Tease each other with berries or drip ice cream, whipped cream, or chocolate syrup on your partner's torso then lick it off (just don't insert any food into/around the genitals to avoid infection).

This app-controlled clitoral stimulator has five modes and intensities. This clitoral stimulator is water resistant and has three speeds and seven patterns. Our large, diverse selection of marriage toys includes something for every couple’s intimacy needs. A shocking snap of a brand new Kmart product has caused a stir online due to its likeness to a certain X-rated bedroom item.

Generally speaking, couples who can explore novel ways of being intimate together tend to fare better in terms of maintaining passion and desire (in addition to relationship satisfaction) over the long haul. If the toy is nonmechanized (such as a solid silicone dildo), or mechanized but rated as being splashproof or waterproof, it’s safe to rinse the toy with water in the sink. KURVE features our patented dual-motor Treble and Bass technology™, offering the ultimate in user customisation.

As evidenced above, there are some seriously good sex toys under $100, like the Fleshlight Turbo Blowjob Simulator and Blush Wellness Purple Geo Silicone C-Ring). Vibrating toys, such as vibrating sleeves and wands, provide additional stimulation to the penis during both solo and partnered play. Sex toys, especially men’s sex toys, have evolved way behind cock rings and basic masturbators. These days, there are toys for every flavor of sexual interest and activity. Knowing which ones to buy starts with knowing what’s available.

Simply clip them onto your nipples (or a partner's) and see if you're a fan of the sensation. Have your partner lick or flick your nipples while wearing the clips to elevate the experience further. You've heard of strip poker, but did you know you can make basically any classic board game a sex game? Write down different sex acts on Jenga pieces, and each time you pull a tile, enact what the block says. Or play Monopoly, but barter with sexual favors if you can't pay the rent. While it's not technically a toy, when you write your own rules, you can low-key make anything happen (also, shuffling cards on a bare butt does feel some kind of way).

It feels amazing, whether you're playing with a partner or rocking it solo. This reusable cock ring from Satisfyer is one of the strongest on the market. On its highest setting, this thing feels surprisingly strong. Thankfully, you can dial in a more modest vibration speed, if that's your thing. The larger, more "bulbous" top presses against your partner's clitoris in many sex positions, allowing for maximum stimulation.

Choosing the best sex toy for you or the best couples sex toy can be a challenging process since everyone has different preferences. If you need help selecting products from Babeland, you can email the company’s customer service at or send a question via its online chat. In the lower right-hand corner of the website, there is a help button that brings up a form to fill out.

When you’re ready to shop for sex toys, it’s important to know that not all sexual wellness products are created equal. It is recommended to read customer reviews before committing to a purchase and stick with companies that offer warranties on their products. Here at Bloomi, we replace or refund any defective product with our one-year warranty.

And yes, sex and pleasure can be deeply personal and vary for everyone, as per their needs and desires. It is said that women experience orgasm less than a man during sex; this is where a sex toy comes to the rescue, tying the knot between desire and satisfaction. Once hidden behind the curtains of judgmental looks and the whispers of society, sex toys have now found their place among the people, sparking a revolutionary change by becoming women’s new BFF. It must be said openly and loudly, that they are not just a buzz anymore but have become an intimate companion to many women, changing their journey of sexual exploration and pleasure.

Distributor Vibratex offers a one-year warranty for the Magic Wand Rechargeable. Many of our testers have reported that the Original version has stood up to daily use over the course of many years. Testers reported that the long handle makes the Magic Wand comfortable to hold for long periods of time without hand cramping or numbness. The switch sits high enough on the handle that testers were unlikely to switch it off accidentally during use (which was an issue with some of the smaller rechargeable models).

But that attitude could be adding unneeded pressure and taking some of the fun out of it. When coupled with prostate stimulation, it can lead to powerful—we would argue "mind-blowing"—full-body orgasm. Sure, it's pricey at almost, but trust us, it's worth every penny. “Just be cautious about buying the cheapest toy you can find because some of the ultra-cheap products might be made of questionable materials and have low durability,” says Lehmiller.

When it comes to battery-operated toys, most instructions suggest getting a full charge before use to extend the battery life. Plus, don’t you want to know what all the buttons do so you don’t accidentally switch settings at the worst possible moment? Of course, if you’re going to switch up a toy’s intended use, make sure it’s safe to do so.

We also offer a wide selection of gender expression gear as well as books, lubes and accessories. If you ever have questions about our products or placing an order online, we invite you to email us at [email protected] . We are real humans and we are here to help you find the right toys and accessories to help you enhance your sex life. For newcomers to the world of adult toys, starting with beginner-friendly options is key.

This shop doesn’t contain nudity or porn, and its product descriptions are marriage-centered and include helpful information that suggests how each item can be used to add intimacy during foreplay or while making love. The world of sex toys is not just about sexual gratification; it’s also about exploring new sensations and having fun. From experimenting with different textures and shapes to trying out new types of stimulation, sex toys offer a playground for adults to explore their sexual selves in a safe and enjoyable way. If you’re a Leo, you deserve a sex toy that shines as bright as your personality and still looks cute. Not only is this vibrator shaped like a lipstick, but it’s also adorned with a Swarovski® crystal button. The body of the vibrator can help you tap into your passionate side as you explore your erogenous zones, while the flickering clitoral stimulation will deliver next-level orgasms.

This double dildo, also known as a double-ended or U-shaped dildo, is a great alternative to a strap-on dildo. It has a G-spot friendly 5-inch insertable side for the wearer, and a 6.5-inch insertable side for the receiver. It can also be used for solo play, with one side being used as a handle, but it is mainly designed to be used as a harness-free dildo.

The Dame Kip is a perfectly effective and elegant lipstick-style vibrator, but it is usually more expensive than the equally powerful Satisfyer Purple Pleasure. The Dot also is one of the more accessible toys we have tested. Vibrators with “loop” handles like the Dot’s are easier to grip, and toys that don’t vibrate too much in the handle are gentler on hands. The Purple Pleasure recharges via a magnetic USB charging cord. Satisfyer claims that the toy can operate for up to two hours after three hours of charge time, but the actual time may vary depending on the strength at which you use the toy.

So, you’ll want to fiddle with the tightness until it feels snug, but comfortable. Pair your bondage and BDSM lingerie set with a list of sex toys for couples that will add spice and darkness to any evening soiree. Practice your poker face with wearable, vibrating panties that will have you buckling at the knees or test your limits with derriere and backdoor play with our slick and soft Bobbi vibrator. Experience a whole new world of intensity with the ATOM cock ring, the couples’ sex toy that’s pushing the boundaries of pleasure.

Communication and non-sexual intimacy both seem to trump any kind of toy in terms of boosting relationship satisfaction. Remove the boiled toy from the water with tongs, and allow it to air-dry on a clean towel. Do not rinse with cold water immediately after boiling because the extreme temperature change may stress the material. Meanwhile, the dishwasher can be effective for killing bacteria, but not viruses or fungi.

Then run the dishwasher on the sanitize cycle without soap (which is too harsh to be used with sex toys). This method is not recommended if you share the dishwasher with people other than sexual partners. Combining our patented PulsePlate technology™ with powerful remote-controlled vibrations, this couples’ sex toy can make you both cum hands-free. Its versatile design means it’s the perfect toy for every relationship. Sit back and let the PleX with flex deliver an orgasmic hands-free experience. Metal dildos made from stainless steel are also body-safe and easy to clean.

You have plenty of options when it comes to the best sex toy for your needs. In fact, HUSTLER® Hollywood carries literally hundreds of sex toys for you to peruse. With the amazing variety you’ll find at HUSTLER® Hollywood, you can rest assured you’ll find the right toy. Whether you're in the market for wand massagers, clit-sucking vibrators, rabbits, butt plugs, or something totally out of the box, shopping for sex toys can be pretty freaking overwhelming.

"It gave me clit stimulation in some sex positions that it's hard to pleasure myself in." As for what that stimulation entails? This vibrator boasts five speeds and seven patterns, so you can find the perfect combo to suit your specific pleasure preferences. Here are the 19 best sex toys for couples in 2024, according to sex experts. No matter what type of toy you're buying, you'll want to make sure it's made from body-safe, non-porous materials. Xandebay has thousands of sex toys, adult products and more from the leading brands. Find the perfect adult sex toys from our customer-curated selections.

And, like all Magic Wand models, it’s also useful as a whole-body massager. Shopping for sex toys can be intimidating, for first-time buyers and experienced users alike. This vibe targets both the clit and the G-spot simultaneously, with the potential for inducing explosive blended orgasms. The ergonomic looped handle makes it easy to thrust the toy in and out if you want to, and the smaller arm is flexible enough that it should maintain clitoral contact as you thrust. If you want to overload your clit and G-spot with pleasure, this toy is one of the best and fanciest ways to do it. The outer arm of the toy stimulates the clitoris head with air, creating a suction-like sensation that's incredibly pleasurable.

We have bullet vibrators, clitoral suction, couple's vibrators for sex, vibrators for beginners, G spot vibrators, app enabled vibrators, sex machines, and wand vibrators. If you're nearby one of our stores, a Romance Specialist™ can help you find what fits your specific desires. Remember, a sex toy compatible lube makes all of the difference! No matter where you fall on the spectrum, there are so many possibilities for you to enjoy toys, whether alone or with a lover. Lover's Lane® has years of experience procuring high quality sex toys and sex toy accessories online.

This double-ended waterproof strap-on offers three vibration speeds and seven patterns for both the penetrating and receiving partner. The short dildo that goes inside the wearer is 3.5 inches long, the long dildo is 5.5 inches long and is curved to stimulate either the G-spot or prostate, making it a perfect toy for vaginal penetration and/or anal pegging. Plus, this strap-on features a raised nub to stimulate the wearer's clit for added pleasure. She calls it "education without embarrassment" because you learn Sexpert adult toys tips discreetly online in the privacy of your own home. Regardless if you're single, dating a lover or happily married, we all benefit from erotic advice to enjoy better orgasms & sexual pleasure.

Fulfill your fantasies with pleasure products from PinkCherry. A popular sex toy for women that has been purchased and used by many women around the world. Women's vibrators are incredibly lovely devices used to experience pulsating vibrations and can be used for solo or partner play for extreme pleasure. As their name suggests, vibrators are vibrating sex toys that offer a variety of speed and intensity settings. They are primarily used for penetrative sex and are an absolute must in every girl's sex toy collection.

We offer the best, customizable, handcrafted toys that can be found online or for sale anywhere. We specialize in uber realistic and fantasy designs and have something for everyone. Taylor Andrews is a balance editor at POPSUGAR who specializes in topics relating to sex, relationships, dating, sexual health, mental health, and more. In her six years working in editorial, she's written about how semen is digested, why sex aftercare is the move, and how the overturn of Roe killed situationships. Don't be afraid to start with some smaller plug options, get used to the sensations, and then upgrade to larger sizes once you decide you enjoy the sensation.

Electrostimulation works off this same principle, when the brain received a signal of stimulation from the genitals, pleasure hormones are released. Don’t use silicone lube with silicone sex toys (unless you put condoms on them) — silicone lube can react with the solid silicone in your toy and damage it. Water-based lube is a safe bet to use with any sex toy (and any condom). There are so many different kinds of sex toys and ways to use them that figuring out where to start can feel a little overwhelming. Going to a sex toy shop and asking someone who works there about different products can be a great way to learn more about sex toys and what might work well for you.

There seems to be dozens of Handy devices displayed on several tables. Each one looks like a cylindrical bluetooth speaker with a rubber sleeve moving (or, rather, stroking) in an up-and-down motion on its side. Get instant access to members-only products and hundreds of discounts, a free second membership, and a subscription to AARP the Magazine.

They’re made to be more resistant to breakage, which means they’re perfectly safe to use. Some people dislike glass dildos because they don’t flex the same as other materials, like silicone, which could make inserting them less comfortable. But since glass is temperature-sensitive, you have the option to warm it up or cool it down, which can create new sensations. The We-Vibe Pivot is a vibrating cock ring with 11 different vibration modes, and like other We-Vibe sex toys, it has Bluetooth capabilities for app-controlled settings and long-distance play. The Pivot costs $109, a lower price than other vibrating cock rings our reviews team considered. The We-Vibe Tango is a body-safe thermoplastic lipstick vibrator that costs $79, has eight vibration patterns, and includes a two-year manufacturer’s warranty.

Although earlier models were made of rubber material for a lifelike feeling, today’s dildos are available in a wide variety of materials. Find a dildo that looks and feels just the right way for your unique needs today. Find the perfect adult sex toy from our customer-curated selections. It makes them relax, they need to understand their bodies better, they have to relieve the sexual pressure or their accomplice is not at all close. Either way, the vast majority masturbate while feeling better. Generally, most people Masturbate to feel good and achieve sexual satisfaction.

“Most beginner kink toys are all about eroticizing erogenous zones that often get ignored, or creating surprising sensations,” Wolfe says. And boy oh boy are there a lot of different types of external vibes. “Strapless strap-ons are ergonomically designed so that one partner can wear the toy and experience a sensation of fullness while also thrusting into a partner,” Finn explains.

“Inserting these for a while each day helps to tone the pelvic floor back to its former glory, making sex feel much better for both partners,” she explains. You deserve to indulge in a bit of self-pleasure in your life. Other benefits can include better sleep, stress release, improved sex, aiding in menstrual cramps, and more. The Wild Flower Enby 2 is a versatile vibrator that can be used both by people with penises and people with vulvas. Shaped like a miniature bicycle seat, the Enby 2 features a vibrating protrusion that expands out to a flexible, flat, triangular silicone surface that transmits the vibrations.

Save when you shop for the best sex toys with these Lovehoney discount codes. Save when you shop for the best sex toys with these Lovehoney discount codes (and Feel Unique discount codes). Embrace the grind with our collection of sex toy grinders designed for external stimulation.

The toy is made from soft, easy-to-clean silicone, and the vibrations are powerful. This Satisfyer vibrator is a fantastic starter toy at a bargain price, especially considering its 15-year warranty. The term sex toy can also include BDSM apparatus and sex furniture such as sex swings; however, it is not applied to items such as birth control, pornography, or condoms. Alternative terms for sex toy include adult toy and the dated euphemism marital aid.

Then, as the butt plug is partially inserted, squeeze the anus with the toy inside, as this can "help the anal sphincters relax and open," Dr. Melancon says. Once it is fully inserted, enjoy the pleasure and fullness you may feel. Butt plugs can also be used in a variety of different ways, both by yourself and with a partner.

When selecting a dildo that’s best for you, you should consider the material, shape, and size. Proper care and usage are important for a safe and enjoyable experience. “You can only get an STI from a sex toy if you actively share it with someone who has an STI,” states Kate Delgado, sex educator at Lioness.

From vibrators and prostate massagers to masturbators and penis rings, adult toys for men offer a myriad of sensations that encourage exploration and self-discovery. They empower individuals to embrace their unique desires, experiment with different forms of pleasure, and achieve heightened levels of satisfaction. Whether used for solo play or shared intimacy, these toys provide a consensual and exciting way for men to unlock new dimensions of pleasure and redefine their sensual journey. We all have been in your place, but everything becomes easy once you find your preferences, likes, and dislikes. If you step inside an adult toy store and do not know exactly what to look for (dildos, vibrators, stimulators, and other paraphernalia), you’ll be intimidated and overwhelmed. In terms of safety, a lot of healthy sex toys probably do exist in stores you’re interested in visiting.

Go hands-free with the clever wrist-strap remote, and push power to the limits when you unleash the LUX’s dedicated Turbo button! Sit back and let the PulsePlate™ deliver a hands-free experience. Remember when Christian not-so-casually bumped into Ana at Clayton's hardware store and bought some masking tape?

That’s not to say you can't secure a great, O-inducing toy for under $50, but generally speaking, investing in higher-quality materials and features can help you level up the sensations, too. Either the toy may have a hole into which a small bullet vibrator can be inserted, or the core of the glass design can be modified to form a standard vibrator. The latter option usually has a plastic cap covering the battery compartment, which will also house any control buttons or switches.

By entering this site you swear that you are of legal age in your area to view adult material and that you wish to view such material. Archeologists believe that the oldest one, unearthed in the Hohle Fels cave in Germany back in 2005, dates back more than 28,000 years. Ever since, dildos have been used in societies throughout history. Our support agent, Olivia, responded within two minutes and asked us questions to help guide us through the purchasing process.

The biggest difference is that not all dildos can vibrate, though some do. The Nova 2 rabbit vibrator has 10 vibration patterns to help you find the intensity that feels right for you. The G-spot internal arm, or the one that’s inserted into the vagina, bends easily, is repositionable, and the tip is cushioned to help fit into your unique internal curves.

When this Swedish manufacturer launched in the early Aughts, it helped break sex toys out of “never talk about sex toys” prison with sculptural, luxe designs. Lelo’s 24K-gold-plated vibrator may be the epitome of a grail toy, but the brand’s “everyday” offerings are some of the most thoughtful, well-made toys on the market, with beautiful packaging and sophisticated designs. Which is why you’ll find them in almost every list of the best sex toys—for men, women, or couples—that we curate. Founded by San Francisco sex educator Joani Blank in 1977, this shop and its employees have been championing sexual health and pleasure for decades. Its staff sexologist, Dr. Carol Queen, even curates an Antique Vibrator Museum for them. So, needless to say, Good Vibrations knows a lot about vibrators—and if a fantastic vibe is what you’re looking for, its site is definitely worth checking out.

Rediscover the joy of connecting with your partner on a deeper level. Embarking on a journey of sexual health and wellness is not just about products; it’s about knowledge and understanding. Explore our resources section, where you’ll find insightful articles, guides, and tips to enhance your intimacy.

Our favorite materials are obviously non-porous, phthalates-free and withtout any dangerous/toxic agents. They can even be sterilized in boiling water, if they don’t contain any electronic components. There are sleeves that can heat up, vibrate, pulsate, and simulate anal and oral sex. There are thousands upon thousands of masturbation sleeves with various textures, but here are a few of our favorites. A prostate massager is a vibrating toy that goes up the anus to stimulate the prostate. “This can be thought of as the male equivalent to G-spot stimulators,” Fleming says.

To meet the growing expectation and to provide more choices, we have different types of sex toys for women online such as dildos, anal sex toys, Kegel balls, clitoral vibrators, G-spot vibrators, massager wands, and much more. Let's be real, the world of sex toys isn't just a fad—it's a universe bursting with opportunities to enhance those intimate moments, and it's here to stay. Whether it's solo play, enjoying anal play with a partner, or navigating the thrilling waters of penetrative sex, there's an adult toy out there that’s got your name on it. Absolutely, if you enjoy using sex toys alone or with a partner, that is part of a healthy sexual wellness routine. Our products live up to our Clean Standard making them even safer to use more frequently. With our sex toys, toxic ingredients will never touch your intimate areas.

For others, employing sex toys is the simplest (or only) method to achieve orgasm — this is particularly true of those with vulvas. External erotic toys stimulate the clitoris and produce an amazing orgasm too! Try something kinky like a clit sucker to discover how great the suction & vibration feels. Using Ben Wa balls strengthens vaginal muscles to produce intensely powerful orgasms. With over 10,000 styles of womens sex toys to choose from it can be overwhelming decision. When you buy female sex toys from us, it's easy to find a personal massager or intimate sex aid you'll love because we've done the hard work for you.

But how does using sex toys impact the satisfaction both partners derive from their relationship? Results from new research into the prevalence and demographics of sex toy use suggest that pleasure in bed and pleasure in a relationship may differ for partners, depending on their gender. As for the gentlemen, the world of sex toys for men has leaped way beyond the basics.

Anal toys and vibrating anal plugs cater to those curious about anal pleasure. These anal toys vary in size and design, making them suitable for beginners and experienced users alike, offering a safe and enjoyable way to explore anal sensations. Lelo’s Sila suction toy is one of our favorites, and this deal includes the Sila and one of Lelo’s other vibrators, the Gigi 2, for an overall discounted price. The Sila is a compact suction toy that’s less intense overall than some of the other suction toys we’ve tested, but according to WIRED writer Louryn Strampe, the gentle stimulation helps build to a satisfying, full-body climax. The Gigi 2 on the other hand is a relatively simple-looking internal vibrator, but its shape is specially designed to reach the internal structures of the clitoris (the G-spot).

There are plenty of great sex toys for women, but every woman has different needs, and your choice of sex toys should reflect your unique, individual needs. HUSTLER® Hollywood definitely has sex toys to suit every woman’s style. Anal sex is an exhilarating experience, but lots of people are very hesitant to try it out because it’s often a very unique experience. Communication is important with sex in general, but it’s especially important when you’re dabbling in something new.

These erotic dolls, made from either plastic or pure silicone components, are made to look and feel just like real Women. When having sex or masturbating with your lover, a massager increases the enjoyment. Intimacy can result in genuine clitoral stimulation from it, increasing satisfaction. Dildos and vibrators may miss your G-spot, but a massager never does, according to sources who claim women need clitoral stimulation to experience a full-blown orgasm.

And with a run time of over an hour, you’ll want to use this every chance you get, solo or partnered. For many, sex toys are a regular and enjoyable part of their sex life. For others, it can be a bit baffling to know where to start. Specially designed to bring pleasure, our sex toy collection ranges from bullet vibrators that help intensify orgasms to constriction rings that can help keep him harder for longer. All our sex toys are designed to add pleasure to those playing solo or with others.

Ideal for penetrative sex and foreplay, these toys are foundational in any adult toy arsenal. They cater to various sexual preferences, ensuring there’s a dildo and sex toy for every desire. HIGH-QUALITY MATERIAL AND DESIGNWe like to look after you so you can focus on you-time.

For example, Charlotte Graham-McLay reported for The Guardian that the Adult Toy Megastore’s sales of sex toys in New Zealand have tripled since Prime Minister Jacinda Ardern declared a month-long lockdown. Now, the Adult Toy Megastore is not to be confused with the Virgin Megastore. The Adult Toy Megastore is based in New Zealand and sells a variety of adult sex toys, which can be purchased online. Given it sells one million sex toy products, it’s no surprise that PinkCherry has become a go-to for sex toy shoppers across the spectrum. Maude understands that great sex begins before the actual sex happens, and that foreplay can start hours before the friction—maybe with a fragrant shower, a serene bath, a slow massage.

We're grouping these three together since they’re all for impact play, but they are all very different devices. A flogger is a multi-tailed scourge (like a whip/lash) that's typically made of soft leather. A paddle is, well, a paddle, and it’s often made of leather or wood. A crop is just like a riding crop (i.e., the one used with horses), and it's often made of leather.

Nu Sensuelle's proprietary motors have allowed it to become a market leader in the bullet category, as the company's bullets are currently the most powerful in the industry. NU SENSUELLE EMPOWERS THE SENSUALLY CURIOUS to experience elevated levels of connection, intensity, and growth. Through comprehensive education and one-of-a-kind, cutting-edge technology, we infuse a spirit of adventure into the lives of every user. By continually innovating our products, we strive to progressively break down barriers and ensure that there is a product on the market for every user– regardless of body-type, relationship, gender identity or sexuality.

Masturbation toys for men, also known as male masturbators adult toys, are custom-made erotic products designed to enhance solo sexual experiences. These masturbation toys are used to simulate different sensations, replicate the sensation of penetrative sex, or provide unique sensations to enhance pleasure during masturbation. This cone-shaped bullet vibrator is beloved by one 'WH' editor because of "how versatile it is." It's now become their "new go-to bullet" that they've tested out during both solo and partner play. If you're looking for a small but mighty vibrator that'll enhance clit stimulation during partnered sex, look no further.

Doc Johnson manufactures over 75% of its products in the US, and has a catalogue of over 2,000 different products. The company’s wide range of offerings includes anal toys, dildos, vibrators, bondage gear, masturbators, and more. Those materials are usually known to be safe for sex toys, but some of those can be porous and others can degrade with time. We included wood in this section, but you need to make sure that the quality of the varnishing product used on the surface is medical grade. For wood toys, look for a phthalates-free & solvent-free water varnish. Buying Sex Toy has always been difficult because you do not feel comfortable visiting the adult toy store and purchasing them.

“I think buying a strap with your partner and having those experiences together can be a really fulfilling experience for both of you,” she says. For example, in lesbian-only spaces, the dildo has historically been a bone of contention as it’s proposed to be representative of an invasion of men. In the same vein, the exact same dildo might be perceived by others as a path towards gender euphoria, or a tool for power play. • Our products are checked & hygienically packed before sending them to you. Also, we ensure the best quality products are delivered to our customers for greater customer satisfaction. They can be soaked in a toy cleaner or rubbing alcohol, boiled for 3-5 minutes, or put in the top rack of your dishwasher with no detergent if your dishwasher has a "Sanitize" setting.

We found that it lasted three and a half hours at maximum speed, spread out over a series of 20-minute intervals; it may last longer at lower speeds. If it runs out of power, you can connect it to the removable AC cord and continue using it. She eventually discovers the maker to be a man called Kerdon, who hides his trade by the front of being a cobbler, and leaves to seek him out. Metro and Kerdon are main characters in the next play in the sequence, Mime VII, when she visits his shop. Erotic furniture is furniture specially shaped for comfort, penetration levels, and stimulation. Also known as sex furniture, it is any form of furniture that can act as an aid to sexual activity.

We also carry a selection of men’s sexy wear, including satin boxers, package-enhancing shorts and mesh thongs. Ultimately, if you’re up for some really out-of-this-world orgasms, take a look at our Aneros Helix Syn Prostate Probe. This luxurious sex toy is perfectly designed to enhance one’s orgasms and it’s one of the most sought-after toys in this category. It’s designed for easy insertion and can pivot back and forth hands-free!

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Joining me today is Catherine Austin Fitts, here to discuss the the upcoming election, the problem of the two party illusion, and how we must remove the propaganda-laden political veil from our eyes and recognize that one president cannot change the broken-by-design system in which we find ourselves (even if they truly wanted to) and take back responsibility for our future from career politicians, oligarchs, and technocrats who care only about their own power and control. We also discuss the impending digital control structure being built around us -- by both the Left and the Right (otherwise simply known as Your Government) -- as we are inundated by never ending indoctrination in the form of corporate media (MSM) and mainstream alternative media (MAM) -- as well as the solutions to overcome this imminent risk. 

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21 hrs ago

Originally published September 8th, 2014, at https://youtu.be/lrAjBlSShDc

Eleven years ago, I started a YouTube project that would change my life forever. On September 2nd, 2013, I picked up my camera and began a conversation through time. Donning the persona of "Past Liam", I documented every other day of my life, speaking to myself one year in the future. Once that year ended, on September 3, 2014, Future Liam took over, filling in his replies on the off days. Past Liam/Future Liam was born.

To celebrate the eleventh anniversary of PL/FL, I will be re-uploading each episode daily to Rumble, Odysee, and other video platforms to help bridge who I was then with who I am now. Get to know me through the lens of my first steps into adulthood, with little idea of the trials and tribulations to come at the end of the decade.

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Song in the background is "Dream Break" by Alex Balanko, available on Bandcamp: https://alexbalanko.bandcamp.com/track/dream-break-2

Thanks for watching!

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Welcome to The Daily Wrap Up, a concise show dedicated to bringing you the most relevant independent news, as we see it, from the last 24 hours.

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Joining me today is Catherine Austin Fitts, here to discuss the the upcoming election, the problem of the two party illusion, and how we must remove the propaganda-laden political veil from our eyes and recognize that one president cannot change the broken-by-design system in which we find ourselves (even if they truly wanted to) and take back responsibility for our future from career politicians, oligarchs, and technocrats who care only about their own power and control. We also discuss the impending digital control structure being built around us -- by both the Left and the Right (otherwise simply known as Your Government) -- as we are inundated by never ending indoctrination in the form of corporate media (MSM) and mainstream alternative media (MAM) -- as well as the solutions to overcome this imminent risk. 

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21 hrs ago

Originally published September 8th, 2014, at https://youtu.be/lrAjBlSShDc

Eleven years ago, I started a YouTube project that would change my life forever. On September 2nd, 2013, I picked up my camera and began a conversation through time. Donning the persona of "Past Liam", I documented every other day of my life, speaking to myself one year in the future. Once that year ended, on September 3, 2014, Future Liam took over, filling in his replies on the off days. Past Liam/Future Liam was born.

To celebrate the eleventh anniversary of PL/FL, I will be re-uploading each episode daily to Rumble, Odysee, and other video platforms to help bridge who I was then with who I am now. Get to know me through the lens of my first steps into adulthood, with little idea of the trials and tribulations to come at the end of the decade.

Past Liam / Future Liam playlist: https://rumble.com/playlists/MD2p3soRsqA

Song in the background is "Dream Break" by Alex Balanko, available on Bandcamp: https://alexbalanko.bandcamp.com/track/dream-break-2

Thanks for watching!

Visit me at https://www.liamsturgess.com/

Listen and buy my music on Bandcamp: https://liamsturgess.bandcamp.com/

Subscribe to my Substack: https://liamsturgess.substack.com/

Join my Locals community: https://liamsturgess.locals.com/

Follow me on Twitter/X: https://twitter.com/TheLiamSturgess

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Welcome to The Daily Wrap Up, a concise show dedicated to bringing you the most relevant independent news, as we see it, from the last 24 hours.

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"Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use.”

09/07/2024

Originally published September 7th, 2014, at https://youtu.be/36VL82Mm0T0

Eleven years ago, I started a YouTube project that would change my life forever. On September 2nd, 2013, I picked up my camera and began a conversation through time. Donning the persona of "Past Liam", I documented every other day of my life, speaking to myself one year in the future. Once that year ended, on September 3, 2014, Future Liam took over, filling in his replies on the off days. Past Liam/Future Liam was born.

To celebrate the eleventh anniversary of PL/FL, I will be re-uploading each episode daily to Rumble, Odysee, and other video platforms to help bridge who I was then with who I am now. Get to know me through the lens of my first steps into adulthood, with little idea of the trials and tribulations to come at the end of the decade.

Past Liam / Future Liam playlist: https://rumble.com/playlists/MD2p3soRsqA

Robin: https://www.youtube.com/user/NeonVlogFreak
Emma: https://www.youtube.com/user/emmadalymusic
Nichelle: https://twitter.com/pipiemonkster

Song at the end is Soldier, available on Bandcamp: https://liamsturgess.bandcamp.com/track/soldier-feat-alex-balanko

Thanks for watching!

Visit me at https://www.liamsturgess.com/

Listen and buy my music on Bandcamp: https://liamsturgess.bandcamp.com/

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09/06/2024

?️ Originally published September 6th, 2014, at https://youtu.be/NhhiZmORqpY ?️

Eleven years ago, I started a YouTube project that would change my life forever. On September 2nd, 2013, I picked up my camera and began a conversation through time. Donning the persona of "Past Liam", I documented every other day of my life, speaking to myself one year in the future. Once that year ended, on September 3, 2014, Future Liam took over, filling in his replies on the off days. Past Liam/Future Liam was born.

To celebrate the eleventh anniversary of PL/FL, I will be re-uploading each episode daily to Rumble, Odysee, and other video platforms to help bridge who I was then with who I am now. Get to know me through the lens of my first steps into adulthood, with little idea of the trials and tribulations to come at the end of the decade.

Past Liam / Future Liam playlist: https://rumble.com/playlists/MD2p3soRsqA

♪ Song at the beginning is Soldier, available on Bandcamp: https://liamsturgess.bandcamp.com/track/soldier-feat-alex-balanko

? Thanks for watching! ?

?️ Visit me at https://www.liamsturgess.com/
? Listen and buy my music on Bandcamp: https://liamsturgess.bandcamp.com/

? Subscribe to my Substack: https://liamsturgess.substack.com/
?️ Join my Locals community: https://liamsturgess.locals.com/
? Follow me on Twitter/X: https://twitter.com/TheLiamSturgess

? Subscribe on Rumble: https://rumble.com/c/liamsturgess
? Subscribe on Sovren: https://sovren.media/u/liamsturgess/
? Subscribe on Odysee: https://odysee.com/@LiamSturgess:1

? Support me directly by PayPal: https://www.paypal.com/paypalme/theliamsturgess
? Buy Me A Coffee: https://buymeacoffee.com/liamsturgess

Posts

3 mins ago


Inferring gestational age from this routine clinical phenotyping data could be useful in resource limited settings which lack obstetric ultrasound. Overall, both the cellular and proteomic analyses validate previously reported phenotypic immunological changes of pregnancy, and uncover new alternations and predictive markers.In patients with HBV and HCV coinfection, HBV reactivation leading to severe hepatitis has been reported with the use of direct-acting antivirals (DAAs) to treat HCV infection. Here we study the molecular mechanisms behind this viral interaction. In coinfected cell culture and humanized mice, HBV replication was suppressed by HCV coinfection. In vitro, HBV suppression was attenuated when interferon signaling was blocked. In vivo, HBV viremia, after initial suppression by HCV super-infection, rebounded following HCV clearance by DAA treatment that was accompanied by a reduced hepatic interferon response. Using blood samples of coinfected patients, interferon-stimulated gene products including C-X-C motif chemokine 10 (CXCL10) and C-C motif chemokine ligand 5 (CCL5), and alanine aminotransferase (ALT) were identified to have predictive value for HBV reactivation after HCV clearance. Taken together, our data suggest that HBV reactivation is a result of diminished hepatic interferon response following HCV clearance and identifies serologic markers that can predict HBV reactivation in DAA-treated HBV-HCV coinfected persons.BACKGROUNDSeizure-induced inhibition of respiration plays a critical role in sudden unexpected death in epilepsy (SUDEP). However, the mechanisms underlying seizure-induced central apnea in pediatric epilepsy are unknown.METHODSWe studied 8 pediatric patients with intractable epilepsy undergoing intracranial electroencephalography. We recorded respiration during seizures and during electrical stimulation mapping of 174 forebrain sites. A machine-learning algorithm was used to delineate brain regions that inhibit respiration.RESULTSIn 2 patients, apnea coincided with seizure spread to the amygdala. Supporting a role for the amygdala in breathing inhibition in children, electrically stimulating the amygdala produced apnea in all 8 subjects (3-17 years old). These effects did not depend on epilepsy type and were relatively specific to the amygdala, as no other site affected breathing. Remarkably, patients were unaware that they had stopped breathing, and none reported dyspnea or arousal, findings critical for SUDEP. Finally, a machine-learning algorithm based on 45 stimulation sites and 210 stimulation trials identified a focal subregion in the human amygdala that consistently produced apnea. This site, which we refer to as the amygdala inhibition of respiration (AIR) site includes the medial subregion of the basal nuclei, cortical and medial nuclei, amygdala transition areas, and intercalated neurons.CONCLUSIONSA focal site in the amygdala inhibits respiration and induces apnea (AIR site) when electrically stimulated and during seizures in children with epilepsy. This site may prove valuable for determining those at greatest risk for SUDEP and as a therapeutic target.FUNDINGNational Institute of Neurological Disorders and Stroke - Congress of Neurological Surgeons, National Institute of General Medical Sciences, Roy J. Carver Charitable Trust.Bromodomain-containing protein 4 (BRD4) is overexpressed in thyroid carcinoma, represents as an important therapeutic target. ARV-825 is a novel cereblon-based PROTAC (Proteolysis Targeting Chsimera) compound. It can induce fast and sustained BRD4 protein degradation. Its potential effect in human thyroid carcinoma cells was studied here. In TPC-1 cells and primary human thyroid carcinoma cells, ARV-825 potently inhibited cell viability, proliferation and migration. Furthermore, ARV-825 induced robust apoptosis activation in the thyroid carcinoma cells. ARV-825 induced BRD4 protein degradation and downregulation of its targets, including c-Myc, Bcl-xL and cyclin D1 in thyroid carcinoma cells. It was significantly more potent in inhibiting thyroid carcinoma cells than the known small molecule BRD4 inhibitors. In vivo studies demonstrated that ARV-825 oral administration potently suppressed TPC-1 xenograft tumor growth in severe combined immunodeficient mice. BRD4 protein degradation as well as c-Myc, Bcl-xL and cyclin D1 downregulation were detected in ARV-825-treated TPC-1 tumor tissues. Taken together, ARV-825 induces BRD4 protein degradation and inhibits thyroid carcinoma cell growth in vitro and in vivo.BACKGROUND In recent decades, long non-coding RNAs (lncRNAs) have been reported as crucial functional regulators involved in ovarian cancer. In the present study, we explored how lncRNA RHPN1-AS1 influences the progression of epithelial ovarian cancer (EOC) through tumor cell-dependent mechanisms. RESULTS The expression of RHPN1-AS1 in EOC tissues was higher than that in para-cancerous control tissues. High expression of RHPN1-AS1 was closely associated with poor prognosis in EOC patients. https://www.selleckchem.com/ N6-methyladenosine (m6A) improved the stability of RHPN1-AS1 methylation transcript by reducing RNA degradation, which resulted in upregulation of RHPN1-AS1 in EOC. In vitro and in vivo functional experiments showed that RHPN1-AS1 promoted EOC cell proliferation and metastasis. RHPN1-AS1 acted as a ceRNA to sponge miR-596, consequently increasing LETM1 expression and activating the FAK/PI3K/Akt signaling pathway. CONCLUSION RHPN1-AS1-miR-596-LETM1 axis plays a crucial role in EOC progression. Our findings may provide promising drug targets for EOC treatment. METHODS We determined the aberrantly expressed lncRNAs in EOC via microarray analysis and validated RHPN1-AS1 expression by qRT-PCR. The RHPN1-AS1-miR-596-LETM1 axis was examined by dual-luciferase reporter assay and RIP assay. The mechanism of RHPN1-AS1 was investigated through gain- and loss-of-function studies both in vivo and in vitro.BACKGROUND Social media use continues to gain momentum in academic neurosurgery. To increase journal impact and engage more broadly, many journals have turned to social media to disseminate research. The Journal of Neurosurgery Publishing Group (JNSPG) established a dedicated, specialized social media team (SMT) in November 2016 to provide targeted improvement in digital outreach. OBJECTIVE The goal of this study was to examine the impact of the JNSPG social media team as measured by increased engagement. METHODS This study analyzes metrics, including impressions, engagements, retweets, likes, profile clicks, and URL clicks, from consecutive social media posts from the JNSPG's Twitter and Facebook platforms between 2/1/2015 and 2/28/2019. Standard descriptive statistics were utilized. RESULTS Between February 2015 and October 2016, when a specialized SMT was created, 170 tweets (8.1 tweets/month) were posted compared to 3,220 tweets (115.0 tweets/month) between November 2016 and February 2019. All metrics significantly increased, including the impressions per tweet (1,646.

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8 mins ago


Masturbators are designed to simulate the sensation of vaginal, anal, or oral intercourse and can provide intense pleasure. They're available in a wide variety of styles, including pocket pussies, sleeves, or realistic molded replicas of body parts. For more advice, seek online help from one of the more reputable sites, such as goodvibes.com, loverspackage.com or evesgarden.com. Various iterations of the vibrator, now available in battery-powered or plugged-in models, have been around since the late 19th century. By directly stimulating the nerves, the device helps activate those that are not responding to the usual methods of arousal.

But that’s just one of the many masturbation sleeves available for purchase. There’s also the Hot Octopuss Pulse Duo, which can be used with a partner with a vulva for a hot shared experience. Dubbed the first “Guybrator,” this toy wraps around the penis and jacks it off using oscillation (or more specifically, something called “PulsePlate Technology”). Originally, they were designed to help vulva owners strengthen their pelvic floor muscles. Others, like the Zalo Desire preheating thruster, are shaped like standard dildos.

For this article, I picked the cream of the crop in the $150-plus range, and also asked some experts about their fave high-end toys to round out the story. The soft silicone of this ring feels luxurious to the touch, and its variety of settings and speeds are fun to experiment with. Another form of sex toys for both men and women are those for erotic electrostimulation. Erotic electrostimulation refers to the act of using electricity for sexual stimulation. By the mid-1970s, medical transcutaneous electrical nerve stimulation (TENS) machines were widely available. The machines work by stimulating nerve endings with electricity, sending signals of stimulation to the brain.

Introducing the PULSE QUEEN, the world’s first wand with PulsePlate Technology™. Setting a new standard for wands everywhere, the PULSE QUEEN delivers high-amplitude oscillations that penetrate deep into your body. Whether you’re a newbie or a power queen, the PULSE QUEEN will have you accessing a whole new orgasm pallet you never knew existed. A stunning, iridescent special edition of our best-selling toy for penis owners, PULSE DRAGON EYE is so sexy to look at, you'll get as much pleasure owning it as using it…well, almost. Sexual activity can provide some assistance with each of these. It can help pass the time, at least a minute for some, longer for others.

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The choice of this high-grade material provides safety in use and the option to heat or chill the toys. Borosilicate glass is also non-porous and can be sterilized to help prevent infection with reuse. The highest quality glass toys can even be put in the dishwasher making them easier to keep clean.

Prolong your pleasure with this silicone C-ring that’s easy to slide on and off. Shop for yourself or a partner and pick from our textured sleeves and crush-worthy products. The truth is, straps have been around since time immemorial – literally. The first historical documentation of a strap-on was during the Upper Palaeolithic period, (a.k.a the Stone Age), about 30,000 years ago. And, in sapphic relationships, they’ve long signified power exchanges, pleasure and, sometimes – but not always, masculine energy. Silicone is non-porous and can be sanitized and disinfected with a toy cleaner, rubbing alcohol, boiling, or dishwashing.

Additionally, the team evaluated thousands of customer reviews and ratings to narrow down the best couples sex toys for a wide range of needs and preferences. Nu Sensuelle offers a wide range of pleasure products and sex toys including bullets, vibrators, anal toys, penis rings, and more. Nu Sensuelle's products are catered towards couples and users of every body type, gender, and sexual orientation, as inclusivity, intimacy and experimentation are at the heart of our core values. The stylishly packaged, versatile and innovative sex toys are backed with the stability of engineering and the guarantee of impeccable customer service. Our sex toys for men are available at a number of different price points. With that being said, don't be afraid to try out a few options of our best sex toys.

A nerdy twist on your average dildos, vibrators and butt plugs!! Tentacle toys, Dragon dildos and Alien appendages, we’ve got the perfect toys to satisfy all your naughty nerdy fantasies. Join us on the socials and tell us which geeky creation you want to see next. Delve into the world of pleasure and intimacy with Honey Birdette's collection of luxury sex toys and vibrators. Ultimate opulence awaits with our sex toys for men, sex toys for women, or indulge your lover with vibrators and sex toys for couples. Vibrators and sex toys designed with pleasure in mind are crafted with high-quality silicone and gold hardware, ensuring they hit the right spot.

Whether it’s finding great products or discovering helpful advice, we’ll help you get it right (the first time). We chose not to test the since-discontinued Unbound Squish because it appeared to be very similar to the Minna Limon, which also offers programmable stimulation and squeeze-pressure technology. Our tester who tried Minna’s similar Ola toy (currently unavailable) found this technology to be more gimmicky than innovative. We tried the 6, which is similar in shape and size to a fountain pen.

Indulge in luxury with the LELO Bundle, featuring the TIANI Duo Blue Dual-Action Couple’s Massager, TOR 2 Black Couple’s Ring, and LELO Personal Moisturizer. Elevate your intimate moments with premium materials, sophisticated design, and unrivaled performance for an unforgettable experience. Free shipping label for eligible returns and a one-year warranty for all Pepper products.

Le Wand makes some of the best wand vibrators on the market, and they’re typically priced pretty high because of that. This one comes decked out with art from illustrator Kelly Malka and still features everything we love about Le Wand vibrators. We recently reviewed the Die Cast version (8/10 WIRED Recommends) and came away very impressed.

Earplugs can be great for BDSM sensory play as a way to help build arousal, anticipation, and even mystery during sex. If https://www.wholesale-sex-toys.com/ ’re both into consensual BDSM and sense play, you can couple this with a blindfold or sleep mask, tie your partner up, and put the earplugs in. Speaking of what's in your kitchen, let's not forget the many ways you can incorporate food into your sex life. Tease each other with berries or drip ice cream, whipped cream, or chocolate syrup on your partner's torso then lick it off (just don't insert any food into/around the genitals to avoid infection).

This app-controlled clitoral stimulator has five modes and intensities. This clitoral stimulator is water resistant and has three speeds and seven patterns. Our large, diverse selection of marriage toys includes something for every couple’s intimacy needs. A shocking snap of a brand new Kmart product has caused a stir online due to its likeness to a certain X-rated bedroom item.

Generally speaking, couples who can explore novel ways of being intimate together tend to fare better in terms of maintaining passion and desire (in addition to relationship satisfaction) over the long haul. If the toy is nonmechanized (such as a solid silicone dildo), or mechanized but rated as being splashproof or waterproof, it’s safe to rinse the toy with water in the sink. KURVE features our patented dual-motor Treble and Bass technology™, offering the ultimate in user customisation.

As evidenced above, there are some seriously good sex toys under $100, like the Fleshlight Turbo Blowjob Simulator and Blush Wellness Purple Geo Silicone C-Ring). Vibrating toys, such as vibrating sleeves and wands, provide additional stimulation to the penis during both solo and partnered play. Sex toys, especially men’s sex toys, have evolved way behind cock rings and basic masturbators. These days, there are toys for every flavor of sexual interest and activity. Knowing which ones to buy starts with knowing what’s available.

Simply clip them onto your nipples (or a partner's) and see if you're a fan of the sensation. Have your partner lick or flick your nipples while wearing the clips to elevate the experience further. You've heard of strip poker, but did you know you can make basically any classic board game a sex game? Write down different sex acts on Jenga pieces, and each time you pull a tile, enact what the block says. Or play Monopoly, but barter with sexual favors if you can't pay the rent. While it's not technically a toy, when you write your own rules, you can low-key make anything happen (also, shuffling cards on a bare butt does feel some kind of way).

It feels amazing, whether you're playing with a partner or rocking it solo. This reusable cock ring from Satisfyer is one of the strongest on the market. On its highest setting, this thing feels surprisingly strong. Thankfully, you can dial in a more modest vibration speed, if that's your thing. The larger, more "bulbous" top presses against your partner's clitoris in many sex positions, allowing for maximum stimulation.

Choosing the best sex toy for you or the best couples sex toy can be a challenging process since everyone has different preferences. If you need help selecting products from Babeland, you can email the company’s customer service at or send a question via its online chat. In the lower right-hand corner of the website, there is a help button that brings up a form to fill out.

When you’re ready to shop for sex toys, it’s important to know that not all sexual wellness products are created equal. It is recommended to read customer reviews before committing to a purchase and stick with companies that offer warranties on their products. Here at Bloomi, we replace or refund any defective product with our one-year warranty.

And yes, sex and pleasure can be deeply personal and vary for everyone, as per their needs and desires. It is said that women experience orgasm less than a man during sex; this is where a sex toy comes to the rescue, tying the knot between desire and satisfaction. Once hidden behind the curtains of judgmental looks and the whispers of society, sex toys have now found their place among the people, sparking a revolutionary change by becoming women’s new BFF. It must be said openly and loudly, that they are not just a buzz anymore but have become an intimate companion to many women, changing their journey of sexual exploration and pleasure.

Distributor Vibratex offers a one-year warranty for the Magic Wand Rechargeable. Many of our testers have reported that the Original version has stood up to daily use over the course of many years. Testers reported that the long handle makes the Magic Wand comfortable to hold for long periods of time without hand cramping or numbness. The switch sits high enough on the handle that testers were unlikely to switch it off accidentally during use (which was an issue with some of the smaller rechargeable models).

But that attitude could be adding unneeded pressure and taking some of the fun out of it. When coupled with prostate stimulation, it can lead to powerful—we would argue "mind-blowing"—full-body orgasm. Sure, it's pricey at almost, but trust us, it's worth every penny. “Just be cautious about buying the cheapest toy you can find because some of the ultra-cheap products might be made of questionable materials and have low durability,” says Lehmiller.

When it comes to battery-operated toys, most instructions suggest getting a full charge before use to extend the battery life. Plus, don’t you want to know what all the buttons do so you don’t accidentally switch settings at the worst possible moment? Of course, if you’re going to switch up a toy’s intended use, make sure it’s safe to do so.

We also offer a wide selection of gender expression gear as well as books, lubes and accessories. If you ever have questions about our products or placing an order online, we invite you to email us at [email protected] . We are real humans and we are here to help you find the right toys and accessories to help you enhance your sex life. For newcomers to the world of adult toys, starting with beginner-friendly options is key.

This shop doesn’t contain nudity or porn, and its product descriptions are marriage-centered and include helpful information that suggests how each item can be used to add intimacy during foreplay or while making love. The world of sex toys is not just about sexual gratification; it’s also about exploring new sensations and having fun. From experimenting with different textures and shapes to trying out new types of stimulation, sex toys offer a playground for adults to explore their sexual selves in a safe and enjoyable way. If you’re a Leo, you deserve a sex toy that shines as bright as your personality and still looks cute. Not only is this vibrator shaped like a lipstick, but it’s also adorned with a Swarovski® crystal button. The body of the vibrator can help you tap into your passionate side as you explore your erogenous zones, while the flickering clitoral stimulation will deliver next-level orgasms.

This double dildo, also known as a double-ended or U-shaped dildo, is a great alternative to a strap-on dildo. It has a G-spot friendly 5-inch insertable side for the wearer, and a 6.5-inch insertable side for the receiver. It can also be used for solo play, with one side being used as a handle, but it is mainly designed to be used as a harness-free dildo.

The Dame Kip is a perfectly effective and elegant lipstick-style vibrator, but it is usually more expensive than the equally powerful Satisfyer Purple Pleasure. The Dot also is one of the more accessible toys we have tested. Vibrators with “loop” handles like the Dot’s are easier to grip, and toys that don’t vibrate too much in the handle are gentler on hands. The Purple Pleasure recharges via a magnetic USB charging cord. Satisfyer claims that the toy can operate for up to two hours after three hours of charge time, but the actual time may vary depending on the strength at which you use the toy.

So, you’ll want to fiddle with the tightness until it feels snug, but comfortable. Pair your bondage and BDSM lingerie set with a list of sex toys for couples that will add spice and darkness to any evening soiree. Practice your poker face with wearable, vibrating panties that will have you buckling at the knees or test your limits with derriere and backdoor play with our slick and soft Bobbi vibrator. Experience a whole new world of intensity with the ATOM cock ring, the couples’ sex toy that’s pushing the boundaries of pleasure.

Communication and non-sexual intimacy both seem to trump any kind of toy in terms of boosting relationship satisfaction. Remove the boiled toy from the water with tongs, and allow it to air-dry on a clean towel. Do not rinse with cold water immediately after boiling because the extreme temperature change may stress the material. Meanwhile, the dishwasher can be effective for killing bacteria, but not viruses or fungi.

Then run the dishwasher on the sanitize cycle without soap (which is too harsh to be used with sex toys). This method is not recommended if you share the dishwasher with people other than sexual partners. Combining our patented PulsePlate technology™ with powerful remote-controlled vibrations, this couples’ sex toy can make you both cum hands-free. Its versatile design means it’s the perfect toy for every relationship. Sit back and let the PleX with flex deliver an orgasmic hands-free experience. Metal dildos made from stainless steel are also body-safe and easy to clean.

You have plenty of options when it comes to the best sex toy for your needs. In fact, HUSTLER® Hollywood carries literally hundreds of sex toys for you to peruse. With the amazing variety you’ll find at HUSTLER® Hollywood, you can rest assured you’ll find the right toy. Whether you're in the market for wand massagers, clit-sucking vibrators, rabbits, butt plugs, or something totally out of the box, shopping for sex toys can be pretty freaking overwhelming.

"It gave me clit stimulation in some sex positions that it's hard to pleasure myself in." As for what that stimulation entails? This vibrator boasts five speeds and seven patterns, so you can find the perfect combo to suit your specific pleasure preferences. Here are the 19 best sex toys for couples in 2024, according to sex experts. No matter what type of toy you're buying, you'll want to make sure it's made from body-safe, non-porous materials. Xandebay has thousands of sex toys, adult products and more from the leading brands. Find the perfect adult sex toys from our customer-curated selections.

And, like all Magic Wand models, it’s also useful as a whole-body massager. Shopping for sex toys can be intimidating, for first-time buyers and experienced users alike. This vibe targets both the clit and the G-spot simultaneously, with the potential for inducing explosive blended orgasms. The ergonomic looped handle makes it easy to thrust the toy in and out if you want to, and the smaller arm is flexible enough that it should maintain clitoral contact as you thrust. If you want to overload your clit and G-spot with pleasure, this toy is one of the best and fanciest ways to do it. The outer arm of the toy stimulates the clitoris head with air, creating a suction-like sensation that's incredibly pleasurable.

We have bullet vibrators, clitoral suction, couple's vibrators for sex, vibrators for beginners, G spot vibrators, app enabled vibrators, sex machines, and wand vibrators. If you're nearby one of our stores, a Romance Specialist™ can help you find what fits your specific desires. Remember, a sex toy compatible lube makes all of the difference! No matter where you fall on the spectrum, there are so many possibilities for you to enjoy toys, whether alone or with a lover. Lover's Lane® has years of experience procuring high quality sex toys and sex toy accessories online.

This double-ended waterproof strap-on offers three vibration speeds and seven patterns for both the penetrating and receiving partner. The short dildo that goes inside the wearer is 3.5 inches long, the long dildo is 5.5 inches long and is curved to stimulate either the G-spot or prostate, making it a perfect toy for vaginal penetration and/or anal pegging. Plus, this strap-on features a raised nub to stimulate the wearer's clit for added pleasure. She calls it "education without embarrassment" because you learn Sexpert adult toys tips discreetly online in the privacy of your own home. Regardless if you're single, dating a lover or happily married, we all benefit from erotic advice to enjoy better orgasms & sexual pleasure.

Fulfill your fantasies with pleasure products from PinkCherry. A popular sex toy for women that has been purchased and used by many women around the world. Women's vibrators are incredibly lovely devices used to experience pulsating vibrations and can be used for solo or partner play for extreme pleasure. As their name suggests, vibrators are vibrating sex toys that offer a variety of speed and intensity settings. They are primarily used for penetrative sex and are an absolute must in every girl's sex toy collection.

We offer the best, customizable, handcrafted toys that can be found online or for sale anywhere. We specialize in uber realistic and fantasy designs and have something for everyone. Taylor Andrews is a balance editor at POPSUGAR who specializes in topics relating to sex, relationships, dating, sexual health, mental health, and more. In her six years working in editorial, she's written about how semen is digested, why sex aftercare is the move, and how the overturn of Roe killed situationships. Don't be afraid to start with some smaller plug options, get used to the sensations, and then upgrade to larger sizes once you decide you enjoy the sensation.

Electrostimulation works off this same principle, when the brain received a signal of stimulation from the genitals, pleasure hormones are released. Don’t use silicone lube with silicone sex toys (unless you put condoms on them) — silicone lube can react with the solid silicone in your toy and damage it. Water-based lube is a safe bet to use with any sex toy (and any condom). There are so many different kinds of sex toys and ways to use them that figuring out where to start can feel a little overwhelming. Going to a sex toy shop and asking someone who works there about different products can be a great way to learn more about sex toys and what might work well for you.

There seems to be dozens of Handy devices displayed on several tables. Each one looks like a cylindrical bluetooth speaker with a rubber sleeve moving (or, rather, stroking) in an up-and-down motion on its side. Get instant access to members-only products and hundreds of discounts, a free second membership, and a subscription to AARP the Magazine.

They’re made to be more resistant to breakage, which means they’re perfectly safe to use. Some people dislike glass dildos because they don’t flex the same as other materials, like silicone, which could make inserting them less comfortable. But since glass is temperature-sensitive, you have the option to warm it up or cool it down, which can create new sensations. The We-Vibe Pivot is a vibrating cock ring with 11 different vibration modes, and like other We-Vibe sex toys, it has Bluetooth capabilities for app-controlled settings and long-distance play. The Pivot costs $109, a lower price than other vibrating cock rings our reviews team considered. The We-Vibe Tango is a body-safe thermoplastic lipstick vibrator that costs $79, has eight vibration patterns, and includes a two-year manufacturer’s warranty.

Although earlier models were made of rubber material for a lifelike feeling, today’s dildos are available in a wide variety of materials. Find a dildo that looks and feels just the right way for your unique needs today. Find the perfect adult sex toy from our customer-curated selections. It makes them relax, they need to understand their bodies better, they have to relieve the sexual pressure or their accomplice is not at all close. Either way, the vast majority masturbate while feeling better. Generally, most people Masturbate to feel good and achieve sexual satisfaction.

“Most beginner kink toys are all about eroticizing erogenous zones that often get ignored, or creating surprising sensations,” Wolfe says. And boy oh boy are there a lot of different types of external vibes. “Strapless strap-ons are ergonomically designed so that one partner can wear the toy and experience a sensation of fullness while also thrusting into a partner,” Finn explains.

“Inserting these for a while each day helps to tone the pelvic floor back to its former glory, making sex feel much better for both partners,” she explains. You deserve to indulge in a bit of self-pleasure in your life. Other benefits can include better sleep, stress release, improved sex, aiding in menstrual cramps, and more. The Wild Flower Enby 2 is a versatile vibrator that can be used both by people with penises and people with vulvas. Shaped like a miniature bicycle seat, the Enby 2 features a vibrating protrusion that expands out to a flexible, flat, triangular silicone surface that transmits the vibrations.

Save when you shop for the best sex toys with these Lovehoney discount codes. Save when you shop for the best sex toys with these Lovehoney discount codes (and Feel Unique discount codes). Embrace the grind with our collection of sex toy grinders designed for external stimulation.

The toy is made from soft, easy-to-clean silicone, and the vibrations are powerful. This Satisfyer vibrator is a fantastic starter toy at a bargain price, especially considering its 15-year warranty. The term sex toy can also include BDSM apparatus and sex furniture such as sex swings; however, it is not applied to items such as birth control, pornography, or condoms. Alternative terms for sex toy include adult toy and the dated euphemism marital aid.

Then, as the butt plug is partially inserted, squeeze the anus with the toy inside, as this can "help the anal sphincters relax and open," Dr. Melancon says. Once it is fully inserted, enjoy the pleasure and fullness you may feel. Butt plugs can also be used in a variety of different ways, both by yourself and with a partner.

When selecting a dildo that’s best for you, you should consider the material, shape, and size. Proper care and usage are important for a safe and enjoyable experience. “You can only get an STI from a sex toy if you actively share it with someone who has an STI,” states Kate Delgado, sex educator at Lioness.

From vibrators and prostate massagers to masturbators and penis rings, adult toys for men offer a myriad of sensations that encourage exploration and self-discovery. They empower individuals to embrace their unique desires, experiment with different forms of pleasure, and achieve heightened levels of satisfaction. Whether used for solo play or shared intimacy, these toys provide a consensual and exciting way for men to unlock new dimensions of pleasure and redefine their sensual journey. We all have been in your place, but everything becomes easy once you find your preferences, likes, and dislikes. If you step inside an adult toy store and do not know exactly what to look for (dildos, vibrators, stimulators, and other paraphernalia), you’ll be intimidated and overwhelmed. In terms of safety, a lot of healthy sex toys probably do exist in stores you’re interested in visiting.

Go hands-free with the clever wrist-strap remote, and push power to the limits when you unleash the LUX’s dedicated Turbo button! Sit back and let the PulsePlate™ deliver a hands-free experience. Remember when Christian not-so-casually bumped into Ana at Clayton's hardware store and bought some masking tape?

That’s not to say you can't secure a great, O-inducing toy for under $50, but generally speaking, investing in higher-quality materials and features can help you level up the sensations, too. Either the toy may have a hole into which a small bullet vibrator can be inserted, or the core of the glass design can be modified to form a standard vibrator. The latter option usually has a plastic cap covering the battery compartment, which will also house any control buttons or switches.

By entering this site you swear that you are of legal age in your area to view adult material and that you wish to view such material. Archeologists believe that the oldest one, unearthed in the Hohle Fels cave in Germany back in 2005, dates back more than 28,000 years. Ever since, dildos have been used in societies throughout history. Our support agent, Olivia, responded within two minutes and asked us questions to help guide us through the purchasing process.

The biggest difference is that not all dildos can vibrate, though some do. The Nova 2 rabbit vibrator has 10 vibration patterns to help you find the intensity that feels right for you. The G-spot internal arm, or the one that’s inserted into the vagina, bends easily, is repositionable, and the tip is cushioned to help fit into your unique internal curves.

When this Swedish manufacturer launched in the early Aughts, it helped break sex toys out of “never talk about sex toys” prison with sculptural, luxe designs. Lelo’s 24K-gold-plated vibrator may be the epitome of a grail toy, but the brand’s “everyday” offerings are some of the most thoughtful, well-made toys on the market, with beautiful packaging and sophisticated designs. Which is why you’ll find them in almost every list of the best sex toys—for men, women, or couples—that we curate. Founded by San Francisco sex educator Joani Blank in 1977, this shop and its employees have been championing sexual health and pleasure for decades. Its staff sexologist, Dr. Carol Queen, even curates an Antique Vibrator Museum for them. So, needless to say, Good Vibrations knows a lot about vibrators—and if a fantastic vibe is what you’re looking for, its site is definitely worth checking out.

Rediscover the joy of connecting with your partner on a deeper level. Embarking on a journey of sexual health and wellness is not just about products; it’s about knowledge and understanding. Explore our resources section, where you’ll find insightful articles, guides, and tips to enhance your intimacy.

Our favorite materials are obviously non-porous, phthalates-free and withtout any dangerous/toxic agents. They can even be sterilized in boiling water, if they don’t contain any electronic components. There are sleeves that can heat up, vibrate, pulsate, and simulate anal and oral sex. There are thousands upon thousands of masturbation sleeves with various textures, but here are a few of our favorites. A prostate massager is a vibrating toy that goes up the anus to stimulate the prostate. “This can be thought of as the male equivalent to G-spot stimulators,” Fleming says.

To meet the growing expectation and to provide more choices, we have different types of sex toys for women online such as dildos, anal sex toys, Kegel balls, clitoral vibrators, G-spot vibrators, massager wands, and much more. Let's be real, the world of sex toys isn't just a fad—it's a universe bursting with opportunities to enhance those intimate moments, and it's here to stay. Whether it's solo play, enjoying anal play with a partner, or navigating the thrilling waters of penetrative sex, there's an adult toy out there that’s got your name on it. Absolutely, if you enjoy using sex toys alone or with a partner, that is part of a healthy sexual wellness routine. Our products live up to our Clean Standard making them even safer to use more frequently. With our sex toys, toxic ingredients will never touch your intimate areas.

For others, employing sex toys is the simplest (or only) method to achieve orgasm — this is particularly true of those with vulvas. External erotic toys stimulate the clitoris and produce an amazing orgasm too! Try something kinky like a clit sucker to discover how great the suction & vibration feels. Using Ben Wa balls strengthens vaginal muscles to produce intensely powerful orgasms. With over 10,000 styles of womens sex toys to choose from it can be overwhelming decision. When you buy female sex toys from us, it's easy to find a personal massager or intimate sex aid you'll love because we've done the hard work for you.

But how does using sex toys impact the satisfaction both partners derive from their relationship? Results from new research into the prevalence and demographics of sex toy use suggest that pleasure in bed and pleasure in a relationship may differ for partners, depending on their gender. As for the gentlemen, the world of sex toys for men has leaped way beyond the basics.

Anal toys and vibrating anal plugs cater to those curious about anal pleasure. These anal toys vary in size and design, making them suitable for beginners and experienced users alike, offering a safe and enjoyable way to explore anal sensations. Lelo’s Sila suction toy is one of our favorites, and this deal includes the Sila and one of Lelo’s other vibrators, the Gigi 2, for an overall discounted price. The Sila is a compact suction toy that’s less intense overall than some of the other suction toys we’ve tested, but according to WIRED writer Louryn Strampe, the gentle stimulation helps build to a satisfying, full-body climax. The Gigi 2 on the other hand is a relatively simple-looking internal vibrator, but its shape is specially designed to reach the internal structures of the clitoris (the G-spot).

There are plenty of great sex toys for women, but every woman has different needs, and your choice of sex toys should reflect your unique, individual needs. HUSTLER® Hollywood definitely has sex toys to suit every woman’s style. Anal sex is an exhilarating experience, but lots of people are very hesitant to try it out because it’s often a very unique experience. Communication is important with sex in general, but it’s especially important when you’re dabbling in something new.

These erotic dolls, made from either plastic or pure silicone components, are made to look and feel just like real Women. When having sex or masturbating with your lover, a massager increases the enjoyment. Intimacy can result in genuine clitoral stimulation from it, increasing satisfaction. Dildos and vibrators may miss your G-spot, but a massager never does, according to sources who claim women need clitoral stimulation to experience a full-blown orgasm.

And with a run time of over an hour, you’ll want to use this every chance you get, solo or partnered. For many, sex toys are a regular and enjoyable part of their sex life. For others, it can be a bit baffling to know where to start. Specially designed to bring pleasure, our sex toy collection ranges from bullet vibrators that help intensify orgasms to constriction rings that can help keep him harder for longer. All our sex toys are designed to add pleasure to those playing solo or with others.

Ideal for penetrative sex and foreplay, these toys are foundational in any adult toy arsenal. They cater to various sexual preferences, ensuring there’s a dildo and sex toy for every desire. HIGH-QUALITY MATERIAL AND DESIGNWe like to look after you so you can focus on you-time.

For example, Charlotte Graham-McLay reported for The Guardian that the Adult Toy Megastore’s sales of sex toys in New Zealand have tripled since Prime Minister Jacinda Ardern declared a month-long lockdown. Now, the Adult Toy Megastore is not to be confused with the Virgin Megastore. The Adult Toy Megastore is based in New Zealand and sells a variety of adult sex toys, which can be purchased online. Given it sells one million sex toy products, it’s no surprise that PinkCherry has become a go-to for sex toy shoppers across the spectrum. Maude understands that great sex begins before the actual sex happens, and that foreplay can start hours before the friction—maybe with a fragrant shower, a serene bath, a slow massage.

We're grouping these three together since they’re all for impact play, but they are all very different devices. A flogger is a multi-tailed scourge (like a whip/lash) that's typically made of soft leather. A paddle is, well, a paddle, and it’s often made of leather or wood. A crop is just like a riding crop (i.e., the one used with horses), and it's often made of leather.

Nu Sensuelle's proprietary motors have allowed it to become a market leader in the bullet category, as the company's bullets are currently the most powerful in the industry. NU SENSUELLE EMPOWERS THE SENSUALLY CURIOUS to experience elevated levels of connection, intensity, and growth. Through comprehensive education and one-of-a-kind, cutting-edge technology, we infuse a spirit of adventure into the lives of every user. By continually innovating our products, we strive to progressively break down barriers and ensure that there is a product on the market for every user– regardless of body-type, relationship, gender identity or sexuality.

Masturbation toys for men, also known as male masturbators adult toys, are custom-made erotic products designed to enhance solo sexual experiences. These masturbation toys are used to simulate different sensations, replicate the sensation of penetrative sex, or provide unique sensations to enhance pleasure during masturbation. This cone-shaped bullet vibrator is beloved by one 'WH' editor because of "how versatile it is." It's now become their "new go-to bullet" that they've tested out during both solo and partner play. If you're looking for a small but mighty vibrator that'll enhance clit stimulation during partnered sex, look no further.

Doc Johnson manufactures over 75% of its products in the US, and has a catalogue of over 2,000 different products. The company’s wide range of offerings includes anal toys, dildos, vibrators, bondage gear, masturbators, and more. Those materials are usually known to be safe for sex toys, but some of those can be porous and others can degrade with time. We included wood in this section, but you need to make sure that the quality of the varnishing product used on the surface is medical grade. For wood toys, look for a phthalates-free & solvent-free water varnish. Buying Sex Toy has always been difficult because you do not feel comfortable visiting the adult toy store and purchasing them.

“I think buying a strap with your partner and having those experiences together can be a really fulfilling experience for both of you,” she says. For example, in lesbian-only spaces, the dildo has historically been a bone of contention as it’s proposed to be representative of an invasion of men. In the same vein, the exact same dildo might be perceived by others as a path towards gender euphoria, or a tool for power play. • Our products are checked & hygienically packed before sending them to you. Also, we ensure the best quality products are delivered to our customers for greater customer satisfaction. They can be soaked in a toy cleaner or rubbing alcohol, boiled for 3-5 minutes, or put in the top rack of your dishwasher with no detergent if your dishwasher has a "Sanitize" setting.

We found that it lasted three and a half hours at maximum speed, spread out over a series of 20-minute intervals; it may last longer at lower speeds. If it runs out of power, you can connect it to the removable AC cord and continue using it. She eventually discovers the maker to be a man called Kerdon, who hides his trade by the front of being a cobbler, and leaves to seek him out. Metro and Kerdon are main characters in the next play in the sequence, Mime VII, when she visits his shop. Erotic furniture is furniture specially shaped for comfort, penetration levels, and stimulation. Also known as sex furniture, it is any form of furniture that can act as an aid to sexual activity.

We also carry a selection of men’s sexy wear, including satin boxers, package-enhancing shorts and mesh thongs. Ultimately, if you’re up for some really out-of-this-world orgasms, take a look at our Aneros Helix Syn Prostate Probe. This luxurious sex toy is perfectly designed to enhance one’s orgasms and it’s one of the most sought-after toys in this category. It’s designed for easy insertion and can pivot back and forth hands-free!

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Affordable Bunk Beds For Kids

Anyone who requires an extremely sturdy bunk bed for kids. This model from South Shore can be separated into two individual beds in the event of needing to do so later on. It also has a straightforward design and comes in a variety of colors.

Families with children who want a an enjoyable and functional sleeping arrangement. This twin-overtwin frame comes with the slide and a ladder so that children can easily climb to the top of the bed.

Price

Bunk beds are a great solution for children who are too young to use regular mattresses, but old enough to appreciate sleeping together. They also can save space and work well in small apartments or rooms where space is limited. Choosing the right bunk bed can be difficult due to the many aspects to consider. Here are some guidelines to assist you in making the best option for your family.

Determine how much you're willing to invest in. There are numerous affordable children bunk beds available. They provide top-quality features at a price that is affordable. The price of a loft bed depends on its dimensions, style and if it comes with storage. Some models come with desks and shelves in one or both of the beds. Some models come with drawers that are ideal for storing clothes and other things. Some slide-style furniture gives a fun touch to the room.

The next step is to decide on the size of bunk bed you require. Typically, bunks are twin-overtwin. However there are other options such as full-overfull, queen-overqueen and other variants. It is also important to decide if you want a ladder or staircase to access the top bunk. If you prefer a staircase, look for a bed like the one made by Francis Loft and Bunks, which has a sturdy steel design built to last. https://articlescad.com/15-up-and-coming-trends-about-best-kids-bunkbeds-42819.html is available in a range of colors. It is also able to be customized to suit your preferences, such as adding stairs or changing the color of the metal.

The materials used to construct a bunkbed are also important. Some manufacturers use metal, while others employ wood. Both are durable, however they have different aesthetics. Some people prefer the natural appearance of wood, while others like the modern, sleek look of metal. Keep in mind that buying a wooden bunk bed may require extra maintenance to keep it from getting damaged by water and insect infestation.



If you're looking for a more space-saving option, look into L-shaped bunk beds. They place the bottom bed perpendicularly to the top bed. This design is ideal for small spaces or rooms with low ceilings as it can save space. There are also bunk beds with trundle beds, which can be pulled out from underneath the bottom bed and offer additional sleeping space to guests or siblings.

Design

Bunk beds are an excellent solution for children's bedrooms. They maximize space and add a playful element to the design, and offer storage. These stylish bunks come in a range of configurations, from twin-over-twin to XL and queen and queen, so you can choose the ideal option for your family's needs.

If you're inclined to buy the most affordable bunk bed available, remember that this is the place where your children will are sleeping every day for the next few years. You want to make sure you're buying a bunk bed that's safe, sturdy, and durable, so consider the material that it's made from.

You should search for beds that are made of solid wood or top quality birch plywood. This will ensure the security of your children. You can also choose a bunk bed that is Greenguard Gold certified, which means the bed meets low chemical emissions standards.

It is also important to think about the dimensions of the bunk bed to make sure that it fits in the bedroom of your children especially its height. The higher the bunk is the more likely children will fall off, so opt for the lowest bed you can. Additionally it is important to keep the bunk bed free from any ceiling fans. This could be risky if children fall into them.

Choose a bunk bed with an angled ladder, such as this Harriet Bee Cvyatko Children's Bunk Bed (our top pick for small spaces) It can be positioned against the wall and takes up less space than stairs. Choose bunk beds with an angled ladder, such as this Harriet Bee Cvyatko Kids Bunk Bed (our best choice for small spaces pick) because it can be placed against the wall and takes up less space than stairs.

Some models include an inflatable slide that kids can enjoy. This isn't necessary, but it can be a fun activity for kids who are active.

Safety

While bunk beds are a great space-saving solution for children, they can also create safety issues. To reduce the risk of accidents, make sure you choose a bunk bed that's been constructed to meet CPSC (Consumer Product Safety Commission) standards and has been tested by a third-party lab. Look for beds that have guardrails at the sides and on the bottom, and a sturdy, solid ladder. It should also be free of any hooks that might cause strangulation to children, and it must not require the use of tools to build or disassemble it.

Since children are likely to climb on bunk beds a lot, safety is an important aspect when purchasing one. A quality bunk bed will have guardrails at each level to ensure that children don't slide off while sleeping. It should also feature sturdy, solid frames that can hold two adults without falling down or breaking. It is important to teach your children how to use the ladder safely and to stress that the bunk on the top is not a place for play. It's also recommended to have parents set guidelines about what can and cannot be hung from the security rails on the top bunk, since things like belts and scarves could easily strangle a child.

Some bunk beds are equipped with a staircase instead of a ladder which can be more secure and easier to climb for younger kids. They are more expensive than ladders and require more space in the bedroom. Some stairs have handrails, or built-in storage which makes them more attractive than ladder models.

A few bunk beds for kids come with optional extras like a slide, for example, that extends out from the upper bed. While they're fun for children, they're recommended for older children and should only be used with adult supervision.

After you've decided on the kind of bunk bed that will work for your family, consider the size of your bedroom to determine the amount of space you have and what other furniture you'd like to add to the room. You'll also need to decide if you'd like a twin over full or full over queen bed, and what color scheme will best fit with the rest of the decor in the room.

Space

Bunk beds can be an excellent option for saving space in a shared room and establishing a unique sleeping arrangement. Children love them. They are also a great choice for rooms with small spaces and with low ceilings, as they free up floor space to allow for furniture or play areas. There are numerous bunk bed designs that mix the look and function. These beds are available in a variety of sizes and styles, such as twin-over-twin, XL & Queen. They can be made to fit into any decor while still providing your children with a comfortable place to sleep. Some bunk beds also feature additional functionalities like built-in storage drawers or desks, which are ideal for kids and teens who enjoy reading or studying in their rooms.

Kids and teens are fond of inviting friends to sleepovers, and a bunk bed could be a great solution. It's not just a cozy place for everyone to crash but also fosters a sense of closeness and camaraderie, which can create memories. Bunk beds are also a good choice for single children who want to create their own unique "cave" or nook where they can play and study.

When shopping for bunk beds, you need to take precise measurements of your children's bedroom so that you can figure out which type and size of bunk bed is suitable for the space. You should also measure the height of the ceiling of the room to ensure that the upper bunk has enough room. This is crucial because a bunk bed that does not have enough clearance could pose safety hazards.

Slumberland offers quality, affordable bunk and loft beds that are designed to make the bedtime experience fun and relaxing for kids of all ages. We have a wide selection of styles and designs to match the personality of every child So you'll be able to find the perfect fit for your family. Once you've found the perfect bunk bed to meet your requirements, choose an excellent mattress of the size that matches the new bedding. Choose the delivery and pick-up options that are most suitable for your schedule.

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Choosing a Small Bunk Bed For Kids

Many manufacturers offer flexibility in their designs. It could be bunks at the bottom that you can put in or take away twins that can be stackable and can be separated at a later time, or ladders that slide on the sides of the bed to make space.

This West Elm treehouse bunk bed comes with a fun, enclosed top for privacy and security. It has an trundle that can be pulled out to accommodate sleepovers.

Size

Bunk beds for kids let you open up the floor, providing a cozy place to play and sleep for two siblings or more. They can be a great way to add style to the room. To find the right one for your child's room, consider their current sitting and standing heights as well as how they are likely to grow over the next year or so to determine which bed will fit the best.

If you're worried about how your children will get over and down the bunks, you should look for ones that feature ladders or stairs that are designed to be secure and easy to use. You can also invest in a trundle which can be used with the bunks to create an additional sleeping space.

A full-sized twin bunk with an integrated staircase is another great option for small rooms. This type of bunk is perfect for younger children who are just getting ready to leave their cribs, and it will give a more mature look that is easily transformed into separate beds for floors when the time comes.

A variety of bunk beds frames can accommodate different mattress sizes. This makes them a perfect option for children of all ages. Choose a model that fits the size of a full or twin mattress.

Some bunks have an extra storage space beneath the lower bunk, which is an ideal place to store bags, suitcases or boxes to be stowed away when not in use. Some bunk beds include a reading nook or desk underneath the top bunk so that your child can relax and read an ebook.

A bunk bed with a treehouse like this one from West Elm, is a great way to bring the outdoors inside. Its playful design will inspire imagination and allow you to sleep for hours. You can pair it with tables and chairs for children to create a study space. If you want something sleeker think about a metal frame bunk bed with a desk built in or a loft that has plenty of space under the top bunk to fit Nod chairs as well as an open bookcase.

Safety

Bunk beds are a fantastic option for families that live in small spaces or who have several children. They can be a good method to reduce the size of the bedroom by putting in two beds in one space however, they must be carefully considered to ensure safety. Children should be supervised at all times when they sleep on the top bunk and it is important to teach them about safety in bed to avoid injuries. Bunk beds have a variety of safety features, including guard rails, ladders and other solid and sturdy frames. These safety measures can avoid injuries and accidents caused by falling, entrapment, or structural failure.

Guard rails on the top bunk are a crucial safety feature, and should be at least five inches higher than the mattress and extend over the entire perimeter of the bed's upper edge. These guard rails should also be secure and made of robust materials. They must not have gaps that could cause children to fall through them. Rails should be securely attached to the frames of bunk beds. The stairs and ladders must be constructed from sturdy materials that are recessed or smooth and don't create sharp points and edges, or snag hazards which could cause injury.

Children should be taught that bunk beds are primarily to be used for sleeping, and should not be used as play areas. It is also crucial to teach them how to use the ladder in a safe manner and to only climb on it when they're asleep. It is also important to ensure that they don't hang anything from the guard rails of the top bunk as this could pose a risk of strangulation. This includes belts and scarves as well as decorations and jump ropes.

Solid frames are another important component of bunk bed security. They should be constructed of high-quality wood and have sturdy connections. These connections should be metal-onmetal to ensure they will last and not become loose over time. They should be properly assembled and checked regularly to ensure that they're sturdy. It is also a great idea to use only high-quality mattresses since they are less likely to be damaged over time.

Stores

Bunk beds are a great solution for any situation, whether you have kids sharing a room or you want to create extra sleeping space for your guests. By stacking beds vertically you open up floor space for dressers nightstands, vanities and more. These sleeping solutions also encourage children to work in a communal space, developing social skills at an early age.

Bunk beds have evolved from their basic and space-saving roots. Apart from being an elegant alternative to traditional single beds, bunks now provide a range of useful features that maximize storage space and help keep the bedroom neat and tidy. You can pick from a range of options, including bunk beds that have drawers under each tier to store toys and clothes. You can choose a bunk bed that has stairs that also serve as storage. This makes it easier to get to the top bunk, while also storing things below.

Some bunk beds can be separated into two beds, which is ideal for children sharing a room, or parents who wish to keep the lower bunk safe for toddlers. Others feature stairs that can be shut off to protect yourself which allows you to securely store your toys and other items while ensuring that your children can only climb up to their bed under supervision. Ladders are a great alternative to stairs. They are safer and more secure and can be moved around the room.

A lot of bunk beds are equipped with a desk beneath the mattress on top, a useful option for children who prefer working at home or require a dedicated study area. A bed that has an integrated desk is a great option to increase productivity while giving your child ample space to spread out the supplies and play. This desk-equipped bed, for instance, is made from high-quality solid wood and comes with chairs and a large desk that's to be suitable for children.

If you're looking for ways to save even more space, consider a loft bed that offers various storage options. This Maxtrix model comes with a ladder and stairs that double as a bookcase and drawers, giving you the ultimate solution for sleep, study and art and craft.

Style



A bunk bed is a fun and stylish option for children to sleep, play, and socialize. You can pick from a variety of designs to find one that is suitable for your child's room. It is also important to make sure the bunk bed is in compliance with safety guidelines and instructions that are provided by the manufacturer to ensure an effective and safe structure.

Standard bunk beds come with two twin-sized beds that are stacked on the top of each other. They are perfect for siblings who share the same room. For a more compact look, opt for the low-rise option that is 50 inches off the ground and offers comprehensive guard rails on the top. If your children prefer a little more height, consider a high-rise bunk. This type of bunk offers more privacy on the upper levels and also comes with an integrated staircase or ladder to make it easier to climb up and back down.

Corner lofts or bunk beds are a excellent option for reducing space and allowing each child to have their own space to sleep. With a perpendicular shape you'll have plenty of space beneath for a cozy reading space or playroom, as well as additional storage. Bunk beds are available in a variety of materials and finishes which allows you to personalize the look to match the decor of your child's room.

Add https://telegra.ph/How-To-Choose-The-Right-Kids-Bunkbed-On-The-Internet-09-09 to the bunk beds of your children to customize their appearance and enhance the functionality. For instance a reading lamp is a great option for the top bunk. A staircase can help older children climb to the top bunk independently. Smart lighting systems let you control the brightness with one button press or voice command.

https://patel-mcculloch-2.hubstack.net/how-to-save-money-on-kids-bunk-beds-for-sale can be incorporated into the bunk bed by using themed bedding and wall art, or by adding some simple decorations like fairy lights. This will enable your children to sleep in an environment that is familiar and reminds them of their favorite activities. You can also easily alter the theme as your children get older and their interests change.