Promotores de salud (i.e., community health workers) have the potential to provide much-needed mental health services in Latinx communities, particularly in areas with provider shortages. This study used qualitative methods to explore promotor/a perspectives on mental health task shifting, with a focus on developing understanding of their definition of a promotor/a, obtaining feedback on the appropriateness of sample content of an evidence-based intervention for anxiety and depression in their community, and considering concerns regarding potential barriers to future implementation of services to Latinxs in a rural community. Promotores de salud (N = 16) were recruited from a network of primary care practices to participate in three semistructured focus groups. Qualitative analyses revealed that promotores viewed themselves as caretakers of their community and believed that mental health care fell within that role. After being presented with materials of an evidence-based behavioral intervention for anxiety and depression during the focus groups, promotores expressed that the sample materials seemed appropriate for their community, as well as a general perception that they could deliver such strategies with future training. Promotores voiced concerns about potential barriers to patients accessing mental health care, including mental health stigma and poor community mental health literacy, and discussed the potential benefits of involving promotores to address some of these barriers. Overall, results of this study indicate promotor/a support of the idea of mental health task shifting, as well as a perception that their involvement may improve future mental health service utilization and engagement among Latinxs in a rural community. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Expectations about the future direct effort in goal-oriented action and may influence a range of life course outcomes, including educational attainment. Here we investigate whether such expectations are implicated in the dynamics underlying the persistence of educational advantage across family generations, and whether such dynamics have changed in recent decades in view of historical change. Focusing on the role of domain-specific (educational) and general (optimism and control) expectations, we examine parallels across parent-child cohorts in (a) the relationships between parental socioeconomic status (SES) and children's future expectations and (b) the associations between children's future expectations and their academic achievement. We estimate structural equation models using data from the prospective multigenerational Youth Development Study (N = 422 three-generation triads [G1-G2-G3]; G1 Mage in 1988 = 41.0 years, G2 Mage in 1989 = 14.7 years, G3 Mage in 2011 = 15.8 years; G2 White in 1989 = 66.4%, G3 sociocultural contexts. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Biopsychosocial models of children's socioemotional development highlight the joint influences of physiological regulation and parenting practices. Both high and low levels of children's baseline respiratory sinus arrhythmia (RSA) have been associated with children's maladjustment, indicative of nonlinear associations. Negative or unsupportive parental responses to children's emotions are consistently linked with internalizing (IP) and externalizing problems (EP), although few studies have examined how associations vary within families. This study examined within- and between-person associations of children's quadratic baseline RSA, negative maternal emotion socialization, and children's problems over 7 years. RSA was measured in 133 3.5-year-old children (72 female) in predominantly middle- to upper-middle socioeconomic status, Caucasian families. Mothers reported on their emotion socialization practices and their children's adjustment concurrently and 1, 5, and 7 years later. Multilevel structural equation models revealed quadratic associations between baseline RSA and both IP and EP at the between-person level, suggesting that children with moderate RSA had fewer adjustment problems, on average, than children with lower or higher RSA. Across time and between families, children displayed more problems if their mothers reported more negative responses to their children's emotions. Within families, IP were elevated on years when mothers reported higher than usual negative responses, and children with either high or low baseline RSA had more problems on years when mothers reported greater than usual negative responses to their children's emotions. Altogether, these findings suggest that high and low baseline RSA may increase the risk for maladjustment, particularly in the time-varying context of aversive emotion socialization practices. (PsycInfo Database Record (c) 2021 APA, all rights reserved).We examined the development of children's positive and negative attitudes toward other-gender peers over 1 year, and explored the longitudinal social consequences of holding positive or negative attitudes on the beholder of these attitudes. Participants were 206 second graders (Mage = 7.18 yrs, SD = .56, 50% girls) and 206 fourth graders (Mage = 9.10 yrs, SD = .66, 44.2% girls) from diverse ethnic racial backgrounds (54.6% White; 17.2% Latinx, 4.4% Black, 5.3% Asian, 2.9% Native American, .7% Pacific Islander, 13.1% other) with average household income ranged from $51,000 to $75,000, and they were assessed in 2 consecutive years. Developmental change was assessed using latent change score analysis, which showed that positive other-gender attitudes increased over time (for boys) whereas negative other-gender attitudes decreased for everyone. Path analyses showed that both positive and negative other-gender attitudes predicted children's perceptions of stressful other-gender interactions and their inclusion expectancies by other-gender peers longitudinally, controlling for same-gender attitudes. We also examined the extent to which the predicted relation between attitudes and inclusion expectancies was mediated by children's perceptions of stressful experiences with other-gender peers. https://www.selleckchem.com/products/ml351.html We found that the extent of mediation varied by the type of attitudes and by children's age. Overall, findings contributed to the understanding of the development of children's other-gender attitudes, and underscored the consequences of these attitudes for the beholder of attitudes. This work also sheds light on the discussion of intervention strategies aimed at improving children's gender-based intergroup relations. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Multiple studies have shown that children conform to majorities in perceptual judgment tasks against their better knowledge. However, these studies report contradictory results about how conformity develops over age. Here, we study variation in conformity over the course of middle childhood we examined potential informational and normative motivations underlying conformity, as well as intracultural variability in their age patterns. We measured conformity in both a public and a private setting among 5- to 11-year-olds from eight different communities in Vanuatu (n = 125, 59 boys), a highly diverse society in the South Pacific. We also explored whether selected sociodemographic variables help to explain individual variation in children's conformity. Conformity is lower in both public and private settings the older ni-Vanuatu children are, with conformity in public settings being subject to more developmental and intracultural variation. We infer that normative conformity is more variable than informational conformity. Moreover, we find that children in higher school classes conform less. Our study combines a developmental perspective with an intracultural comparison, and demonstrates that both the publicness of the experimental situation and intracultural variability are important for the understanding of the age patterns of conformity. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Humans tend to avoid cognitive effort. Whereas evidence of this abounds in adults, little is known about its emergence and development in childhood. link2 The few existing studies in children use different experimental paradigms and report contradictory developmental patterns. We examined effort-related decision-making in a sample of 79 five- to 11-year-olds using a parametric induction of cognitive effort and three paradigms that each involved decision-making between low- and high-effort options but varied in how explicit effort was made. This included a demand avoidance and an effort discounting paradigm. We also probed cognitive processes linked to effort-related decisions, including task performance, metacognitive accuracy, effort perception, and mental demand. We found that children of all ages were sensitive to parametric modulations of cognitive effort as indicated by self-report. In terms of effort-related decision-making we found that overall children demonstrated no implicit behavioral preference for low effort tasks, that older children stated a preference for low effort tasks, and that all children discounted effort. Further, implicit preference in the demand avoidance paradigm was linked to children's metacognitive insight into how well they could perform effortful tasks. These findings strongly suggest that although children are clearly sensitive to manipulations of cognitive effort, whether and when they use this information to guide their decisions to engage in effortful tasks depends strongly on the extent to which effortful features are made salient to them. (PsycInfo Database Record (c) 2021 APA, all rights reserved).The development of strategies that support autonomous self-regulation of emotion is key for early childhood emotion regulation. Children are thought to transition from predominant reliance on more automatic or interpersonal strategies to reliance on more effortful, autonomous strategies as they develop cognitive skills that can be recruited for self-regulation. However, there are few longitudinal studies documenting age-related changes in different forms and dimensions of strategies. The current study tested predicted age-related changes in strategy use in a task requiring children to wait for something they want. Specifically, we examined the longitudinal trajectories of 3 strategies commonly observed in delayed reward tasks self-soothing, seeking attention about the demands of waiting (bids), and distracting oneself. link3 We followed a sample of 120 children (54% male, 93.3% white, from semirural and rural economically strained households) from ages 24 months to 5 years who participated in a waiting task each year. Using growth curve modeling, we found declines in self-soothing, rises and then declines in bidding, and increases in distraction from 24 months to 5 years. Next, we investigated whether strategy use trajectories predicted adult ratings of children's emotion regulation during the task, that is, whether children appeared calm and acted appropriately while waiting. Growth in duration and dominance of distraction use predicted judgments that children were well-regulated by age 5 years, whereas growth in dominance of bidding use negatively predicted being rated as well-regulated. We discuss implications for the understanding of strategy development and future directions, including understanding strategy effectiveness. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

The use of acoustic waves for microfluidic aggregation has become widespread in chemistry, biology and medicine. Although numerous experimental and analytical studies have been undertaken to study the acoustophoretic aggregation mechanisms, few studies have been conducted to optimise the device design. This paper presents a numerical investigation of the acoustophoresis of microparticles suspended in compressible liquid. The wall of the rectangular microchannel is made of Polydimethylsiloxane (PDMS), and Standing Surface Acoustic Waves (SSAW) are introduced into the channel from the bottom wall. First, the relative amplitude of the acoustic radiation force and the viscous drag force is evaluated for particles of different radii ranging from 0.1μm to 15μm. Only when the particle size is larger than a critical value can the particles accumulate at acoustic pressure nodes (PNs). The efficiency of the particle accumulation depends on the microchannel height, so an extensive parametric study is then undertaken to identify the optimum microchannel height. The optimum height, when normalised by the acoustic wavelength, is found to be between 0.57 and 0.82. These findings provide insights into the design of acoustophoretic devices.Visual information often quickly dominates people's judgments of others' competence and performance, including in the selection of leaders and decision makers. Reviewing recent research on static and dynamic visual cues, we discuss how people extrapolate judgments of competence and performance from visual information. We highlight how these two streams of research contribute to understanding performance perceptions and offer future avenues for research integrating the consideration of both static and dynamic visual cues.Adults often understand their lives by constructing personal stories and then living into them. Time and time again, a positive relation has been found between the tendency to build redemptive personal stories wherein negative and challenging experiences ultimately give way to positive endings and prosocial behavior. Here, I review the relevant literature in the interest of advancing the notion that redemptive stories and prosociality exist in a virtuous cycle. Engaging in prosocial acts can stimulate the redemptive framing of one's past. By the same measure, once formed, individuals work to bring the story to life, and the ethos of redemption holds the potential to stimulate and sustain prosocial behavior.Coccidiosis is a disease caused by Eimeria, which represents the first parasitic disease in poultry farming. Among them, E. tenella is a virulent species which specifically colonizes the caecum. The inflammatory response to infection is associated to numerous host proteases including cysteine cathepsins that can be deleterious for tissue and innate immunity integrity. Here, germ-free and conventional chickens were used as models to find out whether the microbiota could modify the intestinal expression of host cysteine cathepsins during coccidiosis. The basal caecal peptidase activity primarily relies on host proteases rather than proteases from the commensal flora. While mRNA levels of E. tenella cathepsins B and L remained unchanged in germ-free and conventional broilers, an overall increase in endopeptidase activity of cysteine cathepsins was found in E. https://www.selleckchem.com/products/rottlerin.html tenella-infected caeca in both experimental models (P less then 0.005). A significant decrease in avian cystatin C transcription was also observed in infected conventional, but not in infected germ-free broilers. Despite an unchanged mRNA level of avian cathepsin L (CatL), its protein expression raised following infection, in parallel with an increased transcription of antimicrobial β-defensins (AvBD1, AvBD2, AvBD4, AvBD6, and AvBD7). Taken together, data support that host CatL is post-translationally upregulated during E. tenella infection, and thus may be involved in the alteration of the gut proteolytic balance. Furthermore, CatL may participate to inflammation occurring during coccidiosis through its known ability to proteolytically inactivates up-regulated avian β-defensins that are key molecules of innate immunity.
The risk of concussion is particularly high in female soccer players. There is no consensus as to why female soccer players are at an elevated risk.

To synthesise current evidence investigating reasons for the increased concussion rate in female soccer players.

Searching of six databases (MEDLINE, Scopus, CINAHL, SportDiscus, Web of Science and the Cochrane Library) and grey literature was performed between 13/07/2020-31/07/2020. Keywords were concussion-related terms, terms relating to female football/soccer and terms relating to the mechanism/cause. No constraints were placed on publication date and quantitative or exploratory studies meeting inclusion criteria were eligible. Exclusion criteria were studies not published in English and qualitative studies.

Several hypotheses were identified to explain increased concussion rates in female soccer players, these include, reduced neck strength/anthropometrics, increased head acceleration, increased ball-to-head concussions, differences in hormones and brain structure/function, and reduced visual awareness.

Promising ideas/reasons have been identified for increased concussion rates in female soccer players. Despite hypothesis generation there is scarce high-level evidence which is required to guide injury prevention and/or rule changes to protect female soccer players. The level of evidence for included studies is level 2-3 with most being observational cross-sectional or cohort studies.
Promising ideas/reasons have been identified for increased concussion rates in female soccer players. Despite hypothesis generation there is scarce high-level evidence which is required to guide injury prevention and/or rule changes to protect female soccer players. The level of evidence for included studies is level 2-3 with most being observational cross-sectional or cohort studies.The tumor microenvironment contains high concentrations of TGFβ, a crucial immunosuppressive cytokine. TGFβ stimulates immune escape by promoting peripheral immune tolerance to avoid tumoricidal attack. Small-molecule inhibitors of TGFβR1 are a prospective method for next-generation immunotherapies. In the present study, we identified selective 4-aminoquinoline-based inhibitors of TGFβR1 through structural and rational-based design strategies. This led to the identification of compound 4i, which was found to be selective for TGFβR1 with the exception of MAP4K4 in the kinase profiling assay. The compound was then further optimized to remove MAP4K4 activity, since MAP4K4 is vital for proper T-cell function and its inhibition could exacerbate tumor immunosuppression. Optimization efforts led to compound 4s that inhibited TGFβR1 at an IC50 of 0.79 ± 0.19 nM with 2000-fold selectivity against MAP4K4. Compound 4s represents a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology.Migraine is a common neurovascular disease which has been classified as the sixth most disabling disorder. Current migraine therapy was triptans, however, riptans can cause contraction of blood vessels. Therefore, novel drugs without cardiovascular effects emerged, such as CGRP and selective 5-HT1F receptor agonists. In this work, a series of pyridinylmethylenepiperidine derivatives were designed, synthesized and evaluated for their 5-HT1F receptor agonist activity. The results in vitro showed that compound C1-C6 displayed potent agonist activities compared with positive drug lasmiditan. Pharmacokinetic properties in rat indicated that 2,4,6-trifluoro-N-(6-(fluoro(1-methylpiperidin-4-ylidene)methyl)pyridin-2-yl)benzamide (C5) possessed high AUC and good bioavailability. In two rodent models of migraine, C5 significantly inhibited dural plasma protein extravasation and c-fos expression in the trigeminal nucleus caudalis. Moreover, C5 showed no effect on vasoconstriction. Through these studies, we identified C5 as a potent 5-HT1F receptor agonist for migraine therapy.
Most studies suggest that people with chronic neck pain (CNP) have decreased balance abilities. However, balance performance during performing concurrent tasks is not clarified.

To investigate balance performance under different sensory and dual-task conditions in people with and without CNP.

Twenty-two women with CNP and twenty-two asymptomatic women were tested using the Biodex Stability System. Overall stability index (OSI), anterior/posterior stability index (APSI), medial/lateral stability index (MLSI) were obtained in two sessions eyes-open and eyes-closed. Both sessions consisted of four conditions quiet standing, rotating head, counting backward, standing on foam. Higher index scores mean poorer balance.

Case-Control study.

A mixed factorial ANOVA (2×8 design) showed that there was a main effect of CNP on OSI, APSI, and MLSI (p<0.001), which indicates that CNP causes poor balance. Further, there was an interaction between CNP and test conditions for only OSI (p<0.05). Simple effects tests showed that patients with CNP had higher OSI in all conditions except standing on foam with eyes-open, and quiet standing and counting backward with eyes-closed (p<0.05). The largest effect size was obtained during rotating head with eyes-open (η
0.301), followed by counting backward with eyes-open and quiet standing with eyes-open (η
0.267 and 0.245). Performing a concurrent task, closing eyes, or standing on foam mostly increased OSI in both groups (p<0.05).

Patients with CNP have poorer balance under different sensory and dual-task conditions. Addressing balance assessment while performing concurrent tasks, especially head rotations, may offer new insights into the management of CNP.
Patients with CNP have poorer balance under different sensory and dual-task conditions. Addressing balance assessment while performing concurrent tasks, especially head rotations, may offer new insights into the management of CNP.
Achilles tendinopathy (AT) is common, and can be traumatic or insidious in onset and short-lasting or persistent in nature. Factors influencing the experience of pain are poorly understood; little is known about mechanisms driving pain and the response (or lack of) to rehabilitation. Despite this, there is a growing body of evidence supporting the use of exercise to manage AT. Interestingly, variation in exercise approach does not appear to significantly impact outcome. Patients' perceptions of factors related to rehabilitation that may influence outcome could provide a valuable addition to help guide future research and practice.

The aim of this study is to gain an insight into patients' experiences of participating in an exercise-based rehabilitation programme for AT.

A qualitative interpretive description design. Data generated from semi-structured interviews were analysed thematically using the guidelines set out by Braun and Clarke.

This is the first study to use a qualitative method of inquiry to gain data on the experiences of people undertaking exercise-based rehabilitation for AT. The four major themes that were identified from the data were (1) 'understanding the impact' (2) 'expectations' (3) 'what matters' and (4) 'the burden of exercise'.

Given the uncertainty surrounding the mechanisms of effect of our treatments, the insights provide a platform from which researchers and clinicians can consider further in the management of people with Achilles tendinopathy. Specifically, it has highlighted that patients value a flexible, supportive approach embracing the biopsychosocial impact of AT on the individual.
Given the uncertainty surrounding the mechanisms of effect of our treatments, the insights provide a platform from which researchers and clinicians can consider further in the management of people with Achilles tendinopathy. Specifically, it has highlighted that patients value a flexible, supportive approach embracing the biopsychosocial impact of AT on the individual.

Bean to Cup Coffe Machine

Bean to cup coffee machines allow coffee lovers to personalize their coffee at the touch of a button. The machines grind the beans, then heat the water and brew it for you.

They also perform rinse cycles prior to turning off and will inform you when the bin requires emptying, making them perfect for busy workplaces and offices.

Freshly Ground Coffee freshly ground

If you're a connoisseur of coffee, then you know that freshly ground beans yield an even more rich and delicious cup of coffee than coffee that has been ground. Whole coffee beans oxidize slower than ground coffee and release more aromas and oils when brewed. Bean to cup machines can be used with whole beans or ground coffee that has been pre-ground. However, most people prefer the flavor of freshly grounded coffee.

A bean-to-cup machine allows you to create delicious coffee with ease. These coffee machines are versatile and include grinders built in that grind the beans for each drink. They can also serve hot milk, creating delicious cappuccinos and lattes with ease. https://blogfreely.net/bobcatrock91/30-inspirational-quotes-about-bean-coffee-machine can be used to create a variety drinks and many of them come with programmable settings to allow you to select the strength and taste you prefer.

The most popular bean-to-cup coffee machines display a variety of hot beverages on the menu screen. There are many options, including a strong espresso, frothy capspuccino, and silky flat-white. Certain coffees let you add a shot of sweetener which is perfect for those on low-carbohydrate diets.

They are simple to use, and can be quickly installed. They are usually plumbed in so that you don't need to worry about refilling water, and you just need to turn them on and push a button. They also perform rinse cycles at the end of brewing, and when they are first switched on to ensure that no traces of coffee residues remain on the coffee spout or the milk container. The grounds that are used up are automatically emptied into a container, which doesn't need to be emptied every day and comes with an indicator that lets you know when it is full.

It is crucial to take good care of your bean-to-cup coffee machine to ensure that it functions efficiently and efficiently as it can. It is important to ensure that these machines are operating at their best by regularly cleaning and descaling them.

Variety of drinks

If you're looking for different coffee types such as cappuccino and espresso, bean to cup machines provide a variety of. Some include hot chocolate options. Some allow you to alter the amount milk and water for a perfect drink every time. This makes them perfect for people who like to experiment with brewing recipes as well as those who prefer consistency and quality.

One of the major advantages of a bean to cup machine is that it grinds the beans just before use, giving them maximum flavour. The flavor of coffee that is ground begins to diminish when it comes in contact with oxygen. A machine that grinds beans only before brewing ensures that your coffee will always be fresh and delicious.

These machines aren't just for home use, they can be found in a wide variety of commercial establishments like hotels, offices, gyms, leisure centres, cafes and restaurants and many more. This is because they're easy to use and don't require any instruction, meaning that anyone can use them with no fuss.

In addition to the standard coffee options like espresso, latte and cappuccino Certain models of bean-to-cup machines can also make hot chocolate, tea and instant fruit juices. This versatility is useful for businesses who want to meet dietary needs.

Certain coffee machines such as the Melitta Aqua Comfort, have separate systems for making frothy cappuccinos or hot chocolate. This lets you make a variety drinks without the need to purchase multiple machines.

Before you make a final decision, you should consider your needs and preferences. The type of coffee maker that you choose will be determined by the size capacity, price, and size of your business. Other factors include whether it's a domestic or a commercial machine, the number of cups it can make per day and the space available.

Convenience

Bean to cup coffee machines are designed to make preparing coffee quick and easy. The machine does the grinding, extraction and usually the milk frothing. This means that employees spend less time brewing their own coffee and more time focusing on their work. It also reduces the amount of waste that is generated in terms of waste and cleaning, as it doesn't require kettles, jars, or filters.

The machine will make a range of drinks which include black and milky cappuccino or espresso hot chocolate, latte, flat white and many more. This is great for cafes, offices and restaurants as they can provide their staff and customers various coffee options with the touch of a button. It is typical for the machine to be plumbed meaning you don't need to worry about stocking up on supplies or refilling water tanks.

A good bean-to-cup machine will usually offer several settings for the grinder, extraction level and other options that can be adjusted according to the type of beans and the flavor you prefer. This is a fantastic feature for coffee lovers who prefer to personalize their drinks each time.

A bean to cup machine has the advantage of using freshly ground beans which gives the coffee the best taste. This is something you cannot get from a machine that grinds coffee pre-ground that can taste weak or bitter. The machines also extract the most flavour from the beans, leading to an incredibly fresh, rich cup of coffee.



A bean to cup machine is the most practical option for commercial settings such as offices and workplaces. The machine makes high-quality coffee at the touch of a button. It is also easier to set up as compared to a traditional espresso machine or individual cups made from filter coffee. It's also much smaller than traditional coffee makers and does not require milk jars or kettles.

To make the most of your bean to cup coffee maker, it is essential to keep it clean and well maintained. The majority of machines have a clear display that lets you know when it's time for routine cleaning and descaling. The system will instruct you to perform these routine tasks. It is best to use only cleaning products that are suitable for your particular machine. In the event that you do not, you could end up voiding your warranty.

Low Maintenance

Bean to cup coffee makers are more practical than traditional coffee makers. They typically feature a state-of-the-art control panel that permits customers to select from a variety of beverage options, including different sizes, strengths and even drinks that are customized. Some models also feature touchscreen functionality that allows staff to make orders without having to touch the machine. These features can boost the efficiency and satisfaction of employees.

One of the main advantages of bean-to-cup coffee machines is that they tend to require less maintenance than traditional machines. It is crucial to clean and decal the machine regularly to ensure it runs efficiently. This will prevent the coffee developing a bad taste and will ensure that the machine is protected from damage.

In general, you'll need to clean the machine by emptying the waste tanks and wiping any surfaces. It is also important to clean the steam pipe which froths milk for cappuccinos or lattes. This pipe can become blocked if left unwashed with the accumulation of bacteria and milk residue.

It is also important to clean the machine on a regular basis to eliminate any scale build-up. This will help protect the machine from damaging the heating element and improve the quality of the coffee. The machine will typically have a built in descaling program that will let you know when it is time to descale.

Bean-to-cup coffee machines are an excellent option for businesses who want to offer fresh, high-quality coffee. They can help businesses save money on expensive coffee and drinks packaging, negate the necessity to purchase coffee frequently and will provide a steady supply of high-quality, fresh-ground coffee. However, it is crucial to consider the specific requirements of your business and be sure that the bean-to-cup machine can meet these needs prior to making a purchase. By following the tips in this article, you'll be able to identify the ideal bean-to-cup coffee machine for your business. If you require further advice, feel free to contact us.

Nohu đổi thưởng là một hình thức chơi game dựa trên máy hoặc trò chơi điện tử, nơi người chơi có thể đổi thưởng với các phần thưởng giá trị. Đây là một trong những trò chơi có tính giải trí cao và được nhiều người yêu thích.

#nohu #nohuonline #nohudoithuong #gamenohu

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To evaluate the value of using both HMG and recombinant FSH (r-FSH) in the GnRH antagonist protocol for women with high AMH.

This retrospective, single-center cohort study was conducted from January 2013 to December 2018. Of 277 GnRH antagonist IVF/ICSI cycles in women with anti-Mullerian hormone (AMH) ≥5μg/L, 170 cycles receiving the combination of r-FSH and HMG (77 with HMG added at the beginning of the GnRH antagonist cycle and 93 with HMG added after GnRH antagonist administration) and 107 cycles receiving r-FSH alone were analyzed. The dynamic hormone profiles and embryonic and clinical outcomes of the patients were evaluated.

We observed significantly lower serum LH levels in the r-FSH+HMG groups during ovarian stimulation. The serum estradiol and progesterone levels were lower in the r-FSH+HMG groups on the trigger day. Nevertheless, there were no significant differences with respect to the number of oocytes retrieved, maturation, fertilization, blastocyst formation rate or ovarian hyperstimulation syndrome (OHSS). The implantation and live birth rates were increased in the r-FSH+HMG groups compared with the r-FSH alone group, with no statistical significance.

HMG for LH supplementation in the GnRH antagonist protocol for patients with high AMH is not significantly superior to r-FSH alone in terms of ovarian response and pregnancy outcome. Nevertheless, HMG supplementation might be appropriate for women with an initially inadequate response to r-FSH or intracycle LH deficiency.
HMG for LH supplementation in the GnRH antagonist protocol for patients with high AMH is not significantly superior to r-FSH alone in terms of ovarian response and pregnancy outcome. Nevertheless, HMG supplementation might be appropriate for women with an initially inadequate response to r-FSH or intracycle LH deficiency.
Fatigue, a painful and unpleasant subjective experience, is common in perimenopausal women. Therefore, an effective tool to evaluate the fatigue-precipitating factor is important for perimenopausal women prone to fatigue syndrome.

This study was surveyed by short-term perimenopausal fatigue scale. The enrollment period was from November 2019 to January 2020. The subjects were perimenopausal women prone to perimenopausal fatigue. The differences between the fatigue-precipitating factors and the degrees of fatigue and disturbance were determined by one-way ANOVA and t test.

A total of 220 perimenopausal women with mean age of 51.3 years were included. Among these, 64.1% did not have a habit of regular exercise and 55.5% had chronic diseases. Fatigue syndrome was found in 64.1% of subjects, who were mainly presented by shoulder and neck pain and sleep problems. There were significant differences between "perimenopausal fatigue" and "duration" (p<0.001); "with and without regular exercise" (p=0.05); and "with and without chronic diseases" (p=0.03).

Our study showed the perimenopausal fatigue syndrome is more frequently found in perimenopausal women who have a co-morbidity (chronic illness) and do not have a habit of regular exercise. An early identification and prompt intervention may help perimenopausal women to deal with their fatigue syndrome. The short questionnaire perimenopausal fatigue scale seems to be useful for screening perimenopausal women prone to fatigue syndrome.
Our study showed the perimenopausal fatigue syndrome is more frequently found in perimenopausal women who have a co-morbidity (chronic illness) and do not have a habit of regular exercise. An early identification and prompt intervention may help perimenopausal women to deal with their fatigue syndrome. The short questionnaire perimenopausal fatigue scale seems to be useful for screening perimenopausal women prone to fatigue syndrome.
To examine the effects of cisplatin on uterine histology and implantation molecules and the possible protective role of recombinant Klotho administration on uterine histology and uterine receptivity in mice exposed to cisplatin.

This study was conducted using thirty-two adult female mice assigned to four groups with 8 mice in each group. Saline was given to the 1st group, cisplatin to the 2nd group, recombinant mouse Klotho to the 3rd group and recombinant mouse Klotho plus cisplatin to the 4th group. Uterine tissues were examined for damage histologically and immunobiologically for the uterine receptivity markers HOXA13 and alphaVBeta3 integrin.

Apoptosis, degeneration, decrease in uterine thickness and uterine absence of gland scores were higher in the cisplatin group (3rd group) compared to the saline group (1st group) (cisplatin vs. saline p<0.0001 for all parameters). In the recombinant Klotho plus cisplatin group (4th group), scores of apoptosis, degeneration, reduction in uterine thickness andsaline p less then 0.0001 for all parameters). In the recombinant Klotho plus cisplatin group (4th group), scores of apoptosis, degeneration, reduction in uterine thickness and uterine absence of gland were lower than the group receiving only cisplatin (cisplatin plus recombinant Klotho vs cisplatin, p = 0.006 for apoptosis; p = 0.017 for degeneration; p = 0.011 for the reduction in uterine thickness; p = 0.002 for the absence of gland). However, HOXA13 and alphaVBeta3 integrin staining levels were not different between the cisplatin group (group 3) and the cisplatin plus recombinant Klotho group (group 4) (p = 0.980 and p = 0.762, respectively.) CONCLUSION Cisplatin has adverse effects on the uterus. Administration of recombinant Klotho was found to attenuate the cisplatin-induced damage but failed to preserve levels of the implantation molecules HOXA13 and alphaVbeta3. Further studies examining the effect of cisplatin toxicity using other implantation markers along with functional studies are needed.
Acute hyperglycemia affects the fetoplacental circulation. This study aims to investigate the possible effect of acute hyperglycemia induced by 50g oral glucose tolerance test (OGTT) on fetoplacental circulation in women between 24 and 28 weeks of gestation.

Between January 2019 and April 2019, a total of 29 women who were between 24 and 28 weeks of gestation with a singleton gestation and were in low-risk group were included in this prospective study. All patients underwent fetal biometric measurements using ultrasonography (USG) and were administered 50g OGTT. Before and 1h after the test, Doppler USG was used to measure uterine artery, umbilical artery (UA), middle cerebral artery (MCA), pulsatility index (PI), resistance index (RI), and systolic/diastolic (S/D) ratio. The cerebroplacental ratio (CPR) was calculated as the ratio of the MCA-PI/UA-PI.

There was a decline in the MCA-RI (p=0.008) and UA-PI (p=0.021) at 1h after the administration of 50g OGTT. Z-scores of the mean UA-PI, MCA-PI, and CPR were calculated and a statistically significant increase in the Z-scores of the mean UA-PI was observed (p=0.028).

Our study results show that acute hyperglycemia induced by OGTT significantly increases the Z-scores of the UA-PI, affecting the fetoplacental circulation.
Our study results show that acute hyperglycemia induced by OGTT significantly increases the Z-scores of the UA-PI, affecting the fetoplacental circulation.
To evaluate the efficacy and superiority of loop electrosurgical excision procedure (LEEP) in managing stage IA1 cervical microinvasive squamous cell carcinoma (MISCC) without lymph-vascular space invasion (LVSI).

The oncological and reproductive outcomes of a series of patients affected by stage IA1 MISCC without LVSI, initially treated by LEEP between February 2006 and December 2017, were retrospectively reviewed.

Ultimately, 109 patients were included. The mean age at diagnosis was 35.4 years old, and 36 patients were nulliparous. Multifocal lesions were identified in 15 patients (13.8%). The mean cone depth was 17.4mm. Resection margins were positive/unevaluable and negative in 26 (23.9%) and 83 (76.1%) cases, respectively. Among cases undergoing salvage treatments, the residual disease rate for patients with positive/unevaluable margins was significantly higher than those with negative margins (P=0.003). During the follow-up period of 43.0±28.9 months, no relapse was identified. Fifteen of 20 patients (75.0%) conceived successfully, with a full-term live birth rate of 93.3%.

For stage IA1 MISCC without LVSI unexpectedly found in a loop excision, initial LEEP with clear margin is efficient and adequate. For cases with multifocal MISCC, or for those young patients who wish to become pregnant in the future, LEEP is the optimal choice.
For stage IA1 MISCC without LVSI unexpectedly found in a loop excision, initial LEEP with clear margin is efficient and adequate. For cases with multifocal MISCC, or for those young patients who wish to become pregnant in the future, LEEP is the optimal choice.
Endometriosis is a bothersome disease affected women worldwide, the mechanism of disease development is still under investigation. Several inflammatory responses after clinical hyaluronic acid (HA) use were reported. Cyclooxygenase (COX)-2 mediated inflammation pathway is involved in the pathogenesis of endometriosis. Thus, we tried to investigate the inflammatory role of hyaluronic acid in endometriosis.

Peritoneal fluid was collected in endometriosis and disease-free patients for the measurement of HA. Endometriotic stromal cells were treated with IL-1β and HA and expression of COX-2 was evaluated. Mice model of endometriosis was established and treated with fluid or gel form of HA. Endometriotic lesion size and weight were recorded and level of COX-2 was evaluated by immunohistochemistry staining.

The level of HA in the peritoneal fluid had no statistically significant difference between normal, early and advanced stage endometriosis patients. https://www.selleckchem.com/products/AV-951.html The overexpression of COX-2 protein was detected when trenflammatory response followed by chronic anti-inflammatory reaction in the formation of endometriosis.
To evaluate the performance of first trimester sonomarkers in the detection of fetal Down syndrome among Thai pregnant women.

Pregnant women at 11-13
weeks' gestation underwent ultrasound examination for assessment of nuchal translucency (NT), nasal bone (NB), tricuspid regurgitation (TR), and abnormal ductus venosus (aDV) Doppler waveforms. The women were followed up for final outcomes. Fetal abnormalities other than trisomy 21 were excluded. The performances of each sonomarker and their combinations in predicting fetal Down syndrome were calculated.

A total of 7820 pregnant women meeting the inclusion criteria were available for analysis, including 20 cases with fetal Down syndrome and 7800 unaffected cases. Of the four sonomarkers, NT, as a single sonomarker, had the highest detection rate (55.0% at a false positive rate of about 5%), whereas the remaining single sonomarkers had low detection rate (15-20%). The combination of all sonomarkers had the highest detection rate of 70% but the false positive rate was as high as 10.8%. The combination of NT and NB had a detection rate of 60% with an acceptable false positive rate of 6.9%, whereas the other combinations yielded relatively high false positive rates.

The first trimester genetic sonogram in screening for Down syndrome among Asian women is acceptably effective and may be offered to some selected groups of the population. NT is the best sonomarker with a detection rate of 55% at 5% false positive rate and its combination with NB can improve performance with minimal increase in false positive rate.
The first trimester genetic sonogram in screening for Down syndrome among Asian women is acceptably effective and may be offered to some selected groups of the population. NT is the best sonomarker with a detection rate of 55% at 5% false positive rate and its combination with NB can improve performance with minimal increase in false positive rate.