He obtained no journey grant from the Academy, despite his receiving the gold medallion. In 2003, literary critic Harold Bloom named Roth one of the four main American novelists nonetheless at work, together with Cormac McCarthy, Thomas Pynchon, and Don DeLillo. The grille is from the Renaissance interval and is mainly composed of stable forging, the band containing the inscription, the seven branched Menorah, the 2 lions and the band underneath, which is a combination of cast and repoussee work, hammered into the relief from the reverse facet. Across the top of the gates, a simple band bears the inscription: "In reminiscence of Jacob H. and Therese Schiff." On both side of this inscription are the symbols of the Lion of Judah, which symbolizes that out of those gates will come the defenders of the Jewish people.

In a thirties guidebook, it's written about the Seminary, "Ensure to note the main gate to the seminary as you go in. It's hand-wrought iron and the entire design is symbolic." These gates have been presented on September 26, 1934, by Mrs. Frieda and Mr. Felix M. Warburg in reminiscence of her mother and father, Jacob H. and Therese Schiff. This arrangement was carried into impact April 14, 1902. The brand new group was endowed with a fund of over $500,000, and was offered with a suitable building on University Heights by Jacob H. Schiff. The gates are there to point out that here Jacob H. Schiff constructed for JTS a gate of examine, of studying and of teaching. JTS was the founding establishment of Conservative Judaism in America. Whereas at Chicago in 1956, Roth met Margaret Martinson, who grew to become his first spouse in 1959. Their separation in 1963, and Martinson's subsequent demise in a automotive crash in 1968, left a long-lasting mark on Roth's literary output.



The Olympic data are held by David Rudisha, who ran a world file of 1:40.91 minutes in 2012, and Nadiya Olizarenko, who ran a former world file of 1:53.Forty three minutes in 1980. Olizarenko's mark is the joint longest-standing women's Olympic document (technically set three days after Ilona Slupianek's shot put file) and the joint second-longest after the males's lengthy soar document by Bob Beamon. https://vocal.media/authors/ovesen-rasmussen , Roth's twenty ninth e-book, was revealed on September 16, 2008. Set in 1951, through the Korean War, it follows Marcus Messner's departure from Newark to Ohio's Winesburg College, where he begins his sophomore yr. Firdasari played the 2007 BWF World Championships in ladies's singles, and was defeated within the second round by Xu Huaiwen of Germany, 21-17, 22-20. She played on Sudirman Cup for Indonesia, who completed second to China in 2005 and 2007. Within the 2008 Singapore Super Sequence, she made a surprise by beating the first-seeded Pi Hongyan of France, 21-16, 20-22, 21-16 in the second round.

He won the males's doubles title on the 2017 World Championships with Zhang Nan, and was a part of the Chinese staff that gained the Sudirman Cup in 2015 and 2021, the Thomas Cup in 2018, and also the Asian Video games in 2018. Liu introduced his retirement by means of his social media account on 30 June 2022. The 2022 Thomas Cup was his last tournament. Dempsey, Joe (October 28, 2015). "The Intercourse-Obsessed Cyberpunk Dystopia of Shimoneta".

This activity benefits both the participant and the clinician or researcher by helping youth to communicate how they make sense of the world, honoring different ways of knowing and prompting recollection of coping appraisals and resilience factors.

Participant-generated timelines are a developmentally appropriate and interactive strategy for assessing youth perceptions of their internal strengths. In conjunction with traditional assessments, this strategy may support the identification of malleable targets for intervention in practice with youth who have experienced adversity or mental health challenges.
Participant-generated timelines are a developmentally appropriate and interactive strategy for assessing youth perceptions of their internal strengths. In conjunction with traditional assessments, this strategy may support the identification of malleable targets for intervention in practice with youth who have experienced adversity or mental health challenges.A glycal based expeditious synthesis of novel nucleoside analogues of (+)-anisomycin is reported. https://www.selleckchem.com/products/nedisertib.html Readily available tri-O-benzyl-D-glucal was converted to a partially protected trihydroxypyrrolidine that is used as a common scaffold for the introduction of various nucleobases at the primary hydroxyl centre. Nucleoside analogues possessing all four DNA bases have been synthesized. Selective acetylation at C3 position was carried out with two of these unnatural nucleosides in order to mimic the structure of (+)-anisomycin. Cytotoxicity studies of some of these nucleosides showed that they display weaker activity on HeLa cells than Ara-C.Holstein × Gyr and Holstein are the primary dairy breeds used in tropical systems, but when rearing under pasture, feed intake, behavior, and performance might differ between them. This study aimed to evaluate the voluntary intake, nutrient digestibility, performance, and ingestive behavior of Holstein and Holstein × Gyr (½ Holstein × ½ Gyr) heifers managed in a rotational system of Guinea grass (Panicum maximum Jacq. cv. Mombaça). The experiment was conducted during the summer season throughout four periods of 21 d. Two 8-heifers (four Holstein and four Holstein × Gyr) groups, averaging 258.6 ± 24.79 kg and 157.1 ± 24.99 kg BW, were used. Each group grazed a separate set of 16 paddocks, and all heifers received a concentrate supplement daily. Heifers were weighed at the beginning and end of the experiment. Fecal, forage and concentrate samples were evaluated for their DM, CP, crude fat, ash, NDF, and indigestible NDF. Feeding behavior was evaluated through 24 h of live observation for 48 h of each experiment, even though the behavior was not markedly different between breeds, rearing young Holstein heifers in tropical pasture conditions is less suitable than Holstein-Gyr because of their lower ADG. Therefore, this management condition seems appropriate for Holstein × Gyr but inappropriate for Holstein dairy heifers.Short-term nutrient restrictions can occur naturally in extensive beef cattle production systems due to low feed quality or availability. The aims of the study were to (1) model the curves of milk yield, plasma non-esterified fatty acids (NEFAs) and β-hydroxybutyrate (BHB) contents of beef cows in response to short nutritional challenges throughout lactation; (2) identify clusters of cows with different response profiles; (3) quantify differences in cows' response between the clusters and lactation stages. Data of BW, body condition score (BCS), milk yield, NEFA, and BHB plasma concentration from 31 adult beef cows (626 ± 48 kg at calving) were used to study the effect of 4-day feed restriction repeated over months 2, 3 and 4 of lactation. On each month, all cows received a single diet calculated to meet the requirements of the average cow 100 % requirements for 4 days (d-4 to d-1, basal period), 55 % requirements on the next 4 days (d0 to d3, restriction period) and 100 % requirements for 4 days (d4 to d7, rhways to respond to and recover from the challenge.Cryoinjury and protein changes are a consequence of cryopreservation and may have a negative impact on sperm quality regarding motility, viability and fertilizing ability. However, potential proteomic changes in rabbit semen throughout the cryopreservation process have never been previously investigated. The aim of the present study was to compare the whole proteome of fresh and cryopreserved rabbit semen (spermatozoa and extracellular fluid), to examine the effects of freeze-thawing on proteins changes in semen. Comparative analysis and identification of proteins was carried out using 2-dimensional difference in-gel electrophoresis coupled with a matrix-assisted laser desorption/ionization mass spectrometry. Proteomic raw data are available via ProteomeXchange with identifier PXD034832 for spermatozoa and PXD034853 for extracellular fluid. Respectively, 107 and 28 proteins differed in abundance in spermatozoa and extracellular fluid between fresh and frozen groups. Most of these proteins were involved in pathways related to energy metabolism and protein quality control under stress conditions, reproductive processes and mechanisms of cell death/survival regulation, resulting in a significant decrease of motility and viability of post-thawing rabbit sperm and its potential fertilizing ability. These results broaden the understanding of the effects of cryopreservation on rabbit semen and represent a new starting point for the development of improved freezing procedures.l-carnitine is a well-known an antioxidant that enhanced lipid metabolism. Therefore, this study investigated the influence of supplementing l-carnitine (LC) to in vitro culture medium on preimplantation development, quality, cryotolerance and transcription profile of candidate genes. Following in vitro fertilization, embryos at zygote stage were cultured with medium supplemented with LC at 1.5 mM and fetal calf serum (FCS) at 0, 2.5, 5, 7.5 and 10% of the CR1-aa culture media. Intracellular quality of produced embryos was measured using different fluorescent stains that measured reactive oxygen species (ROS), lipid and mitochondria intensities. In addition, total cell number and total apoptotic cells were counted per embryo. Quantitative expression of candidate genes was conducted to find out molecular response of embryos after treatment. Moreover, vitrification was done at day 8 of preimplantation development to evaluate post-thaw embryo viability. The results indicated improved blastocyst formation rate atd under low FCS (2.5% and 5%) combined with LC supplementation. On the other hand, genes regulating lipogenesis were down-regulated (ACSL3 and S1PR). It can be concluded that LC is an efficient culture media supplement when added with FCS at 2.5 and 5% which improved blastocyst development rate and quality. These improvements are due to enhanced utilization of intracellular embryo lipid that subsequently increased cryotolerance through orchestrating genes involved in various activities of bovine embryos.Busulfan (Bus), is an alkylating agent widely used in chemotherapy which has been proven to possess toxic side effects on testicles. This study was carried out to compare the probable treatment effects of resveratrol (Res) or/and l-carnitine (Lca), as strong antioxidants, on the testicular tissue as well as on the level of sex hormones in busulfan-induced azoospermic rat models. A total of 78 adult male rats, were divided into six different experimental groups including 1) Control; 2) Lca + Res; 3) BUS; 4) Bus + Lca; 5) BUS + Res and 6) Bus + Lca + Res. Busulfan was intraperitoneally administered in a single dose (10 mg/kg b.w), while resveratrol (20 mg/kg b.w/day) and l-carnitine (200 mg/kg b.w/day) were orally administered by gavage during 48 consecutive days to the rats. At the end of the experiment in all groups the level of LH, FSH, and testosterone were biochemically analyzed by ELISA and the testicular tissue evaluated histologically using stereological technique. Results showed that Lca or/and Res, increased the body and testis weight, the volume of the testis, interstitial tissue, germinal epithelium, and seminiferous tubule, the number of the different cells of germinal epithelium and the level of testosterone. On the other hand, Lca, Res and their combination decreased the concentration of LH and FSH compared to the group treated with Bus. In conclusion, these results suggested that l-carnitine or/and resveratrol treatment significantly attenuated busulfan -induced changes of the rat reproductive system led to the recovery of both testis and sperm parameters. However, co-administration of L-ca and Res was more effective than their individual treatment. This combination may alleviate the side effects of alkylating drugs, such as busulfan and may be beneficial for spermatogenesis.Vascularization is fundamental to the growth and spread of tumor cells to distant sites. As a consequence, angiogenesis, the sprouting of new blood vessels from existing ones, is a characteristic trait of cancer. In 1971, Judah Folkman postulated that tumour growth is angiogenesis dependent and that by cutting off blood supply, a neoplastic lesion could be potentially starved into remission. Decades of research have been devoted to understanding the role that vascular endothelial growth factor (VEGF) plays in tumor angiogenesis, and it has been identified as a significant pro-angiogenic factor that is frequently overexpressed within a tumor mass. Today, anti-VEGF drugs such as Sunitinib, Sorafenib, Axitinib, Tanibirumab, and Ramucirumab have been approved for the treatment of advanced and metastatic cancers. However, anti-angiogenic therapy has turned out to be more complex than originally thought. The failure of this therapeutic option calls for a reevaluation of VEGF as the major target in anti-angiogenic cancer therapy. The call for reassessment is based on two rationales first, tumour blood vessels are abnormal, disorganized, and leaky; this not only prevents optimal drug delivery but it also promotes hypoxia and metastasis; secondly, tumour growth or regrowth might be blood vessel dependent and not angiogenesis dependent as tumour cells can acquire blood vessels via non-angiogenic mechanisms. Therefore, a critical assessment of VEGF, VEGFRs, and their inhibitors could glean newer options such as repurposing anti-VEGF drugs as vascular normalizing agents to enhance drug delivery of immune checkpoint inhibitors.Peer relations inform consumption practices that shape both alcohol use and prescription drug misuse. Integrating studies on pharmaceutical cognitive enhancement with research on consumptive based edgework, this paper examines the role of psychostimulant medications in resolving contradictory aspects of contemporary peer building processes. Drawing on qualitative interviews (n = 162) from a U.S. based study on the context of young adult prescription drug misuse, we demonstrate how medical resources are incorporated into peer bonding rituals in order to enhance consumptive capacity, reduce social risks, and facilitate the accumulation of relational capital. These findings highlight the paradoxical and problematic health ramifications of consumptive based peer bonding practices as well as how psycho-stimulant medications may compound those issues in unintended ways.

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Dr. Mike Yeadon again delivers a MOAB haymaker on Pfizer, Moderna vaccine makers, on Malone, Bourla, Bancel, Sahin, Weissman, Kariko et al. mRNA technology mRNA-LNP vaccine aficionados; Lioness of
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https://palexander.substack.com/p/dr-mike-yeadon-a…
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Dr. Mike Yeadon again delivers a MOAB haymaker on Pfizer, Moderna vaccine makers, on Malone, Bourla, Bancel, Sahin, Weissman, Kariko et al. mRNA technology mRNA-LNP vaccine aficionados; Lioness of
Lioness of Judah Ministry substack, please support! 'it is formally impossible to invent, research, test, evaluate, manufacture, gain authorization for and launch a complex new biological product in

Dr. Paul Alexander
Nov 16, 2024
under a year.’ It's formally impossible. I don't care how much money and people you put on it. There are a series of linear steps which when taken together unless you miss some out cannot be completed under several years. So if someone told you they had brought a brand new airline to market with new engines, in under a year I think you would know it's formally impossible to do a clean sheet design, to stress test the manufacture, to test, to flight test, optimize the engines and get regulatory clearance and be ready to take you across the Atlantic in under a year, and of course it's never been done and it's never been done with complex biological products in under a year.

So whatever else they did they didn't do what they said because it cannot be done in under a year. Secondly and I'll come to the examples in a moment there are in these products numerous features which, in my view, my peers people like me, people with my training and experience, would know for sure would give rise to the toxicities that I pointed out in 2020.

…I'm going to give you three examples that you can go and test. So the first one is: these are so called gene based products, that is they've got a string of genetic information in them. Now there aren't any products like that that are in routine use anywhere in the world so they brand new technology but what you'll remember they told you that they do is they cause your body to make as a protein whatever was in that genetic code. Now it's absolutely basic Immunology. How is it, do you think, your body knows that what's inside of you is meant to be there and you don't attack it, and yet, if something gets into your body from the outside or a tumour forms, something that shouldn't be in you, your body can recognize that's foreign or non-self and can attack it and the answer is: you tolerate everything that's meant to be inside your body. When you're in your mom's womb we ruled out the ability to attack ourselves. So unless you get an autoimmune disease in later life you play nice with yourself until something gets inside you or something goes wrong inside you.

So, ladies and gentlemen, if you are injected with a genetic sequence that causes you to manufacture a foreign protein whether it's a virus or something out a computer, it's not you and it's not meant to be in you. I assure you your body recognizes that it's been invaded. Something's in there that shouldn't be and it launches a fatal attack on every cell that it thinks has gone wrong it's trying to save you. So that autoimmune reaction, that destruction which your body is trying to is doing because it's trying to protect you. That will happen anywhere in your body, any cell, tissue, organ in your body where, unluckily, your dose of what was injected into you lands.

So if it lands in your heart you could get myocarditis or a heart attack. If it lands in your brain, you could get a stroke or neurological conditions. If it's in your eyes you could go blind. If it's in your ovaries it may sterilize you but that explains in my view, lots of the enormously diverse toxic toxicity that's been seen with these products.

So that's one. Your body is being made to manufacture something that does not belong in it and when that happens everybody with the first lecture of Immunology will understand why that happens. It's not an accident. It's in the design. It's a deliberate choice.

The second one then: What was encoded in the in the so-called “vaccines”? Now we're told it's Spike protein. I don't think there is a natural Spike protein but proteins with sequences like that are known to be acutely toxic to blood cells prompting blood clots, to nerve cells causing them to malfunction and probably other things I don't know anything about. So that's the second thing your body was making was forced to make not only a foreign protein something that didn't belong in your body. Your body was forced to make something that was directly toxic to your body, and the person who chose that sequence knew that's what the property of it was. It's not an accident. It's intentional.

Then the third one is absolutely shocking. It's normal for drugs to be formulated, that is to be wrapped in something, you will see them in capsules or tablets, they might have a coating, if it's an inhaler there might be some liquid with it so it can be propelled… In the case of these injectables they were wrapped in, really, fatty globules called lipid nanoparticles, which means tiny little particles of fat. Lipid nanoparticles: Ladies and gentlemen, there were papers published as early as 2012 which I read a couple of years ago that said that it is well understood in the industry by formulators, that the payload that's contained within lipid nanoparticles when injected into animals and people lead to a disproportionate deposition of the payload into your ovaries.

I remember the day I read that paper I really couldn't sleep. the person who chose to use lipid nanoparticles to formulate the Moderna and Pfizer products knew perfectly well that what they would do is allow them to drift all through your body through membranes as if they weren't there and disproportionately deposit in your ovaries and given I've told you the first two things which is: that will induce your body to attack every cell in the body that follows the instructions and that instruction by the way is to make a poison, you should no longer be surprised that people have been injured and killed and had their fertility reduced.

I wish I didn't have to communicate this information but there is no possibility that the people involved in designing these products did not know that they would have the effects that I predicted and that so many people have actually experienced.

It is intentional. There is ample evidence that this assault, which is not the only thing that's ever happened unfortunately, it's the first I noticed. I was a so-called normie until 2020 I believe everything I was told, but this is part of a long planned assault by powerful wealthy people operating above the level of nation.
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Medical Disclaimers apply. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Seek the assistance of health care professionals for any conditions. We are not doctors.
***Medical Disclaimers apply:: """"Forwarding, not a line by line endorsement of all items.""""" **
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Historically India, that is Bharat, has shown its acceptance for refugees and the prosecuted minorities. As a civilization, India has given shelter, unbiased protection and habitation to the Christians from Syria, Zoroastrians (Parsis) from Iran, and Jews since ancient times from the Kingdom of Judah. More recently, Jews also arrived in India from Poland during the holocaust. The constitution of India provides means for meeting the aspirations of the citizen of India of diverse faiths and spiritualism. Since inception it has undergone several amendments from time to time, through a democratic process and by the elected represented in the Indian Parliament This Citizenship Amendment Act, 2019 (CAA 2019) is in continuation of the same ethos of pluralism and civilizational trait of protection for the prosecuted. Authors present their perspective on the misplace outrage on this issue specially propagated through international medical and medical journals.The world is facing the new pandemic COVID-19 caused by a novel coronavirus SARS-CoV-2. The demography and socio-economic condition are highly varied in different parts of the world. India also has braced itself to fight with this novel threat. Patients with COVID-19 may have primary cardiac involvement or may have associated cardiac disease. Therefore, the institution needs a protocol in managing cardiac patients during this pandemic.Nonsteroidal anti-inflammatory drugs (NSAIDs) are used by the patients frequently for pain which may be acute, acute-on-chronic, and chronic. For the relief of pain and inflammation, some patients may take the analgesics without consulting the family physician as they can procure the same easily, not realizing that there may be adverse effects associated with regular self-medication of NSAIDs. The NSAIDs have a risk of upper gastrointestinal bleeding or perforation, which may vary between individual NSAIDs at the doses commonly used by the patients. Thus, there is a need to create awareness in the society regarding the same to prevent self-medication associated complications.In the COVID-19 pandemic, global health care systems have become overwhelmed with potentially infectious patients seeking testing and care. Preventing spread of infection to and from health care workers (HCWs) and patients relies on effective use of personal protective equipment(PPE). The most critical part in due course of managing this pandemic is adequate supply of PPEs. We have customized a PPE which is economical and reusable after proper disinfection. This customized PPE can be a solution to conservation of supply during this pandemic.In the changing global socio-economic and epidemiological landscapes, non communicable diseases (NCDs) are affecting the health and wellbeing of populations. The burden is worse among people in low- and middle-income countries with more than 32 million deaths attributable to NCDs each year. This scenario can be explained through the concept of collateral damage, where intentional actions often lead to adverse consequences alongside the primary outcomes. Thus, NCDs can be viewed as collateral damage of unplanned urbanization, rapid globalization, fast pace of life etc., In addition, a lack of appropriate public health approaches has aggravated the situation. It is essential to build a collaborative approach engaging public health agencies to ensure that the developmental initiatives are without the threat of collateral damages and are people-friendly. This will help in reducing the burden of NCDs in primary care settings.Currently no drug is approved for the prophylaxis and management of COVID 19. Lots of activities on vaccine and trials with drugs are underway. Some evidence have shown positive results using older established drug in the management of severe cases. We are also of same view and opinion to adopt some emergency measure by pharmacological intervention till a newer drug available in the market.The disability viewpoint is fundamental for understanding and advancing social justice for everyone in the population. Despite this fact, it is regularly dismissed by public health experts and policymakers. Understanding of disability rights is central in an all-inclusive COVID-19 preparedness. This paper attempts to explore disability ethics in understanding structural discrimination, equitable practices, respect for disability culture and ways to safeguard health care professionals with disabilities in the coronavirus pandemic. In crisis standards of care, resource allocations must not be solely based on a disabled person's subjective quality of life. Health professionals should avoid stereotypes about an individual's disability to ration care. Triage protocol committees and disaster risk reduction working groups should explicitly recruit people with disabilities and chronic illnesses in their response strategies. Disability ethics can reform medical rationing by removing prejudices and safeguarding fair protection of the interests of all patients, including those with a disability.Covid-19 has once again brought into focus our limited preparedness to deal with epidemics. https://www.selleckchem.com/products/ag-120-Ivosidenib.html Most nations, across the globe, have responded with a resolve to come stronger out of this crisis and leaderships across the world have shown great commitment to protecting its people from Covid-19. Covid-19 has also taught us a few things for the future. One such learning has been that a strong shift in focus towards non-communicable diseases driving health infrastructure across the globe for the last few decades has come at neglect of communicable diseases. In that sense, therefore, the current pandemic has been a wake-up call. Organised Medicine Academic Guild (OMAG), an umbrella organization of professional associations gathered a group of health experts to develop a policy document on epidemic preparedness to limit the influence of epidemics like Covid-19.Globally, the consumer food environment is often shaped by market interests rather than emphasizing nutritional quantity and quality. In low- income countries like India, such unhealthy food products are becoming increasingly available, accessible, and affordable to the common people, especially the school going children, which is a major concern to us. Despite huge amount of evidence, public health institutions are not addressing this pressing issue adequately. It could be due to the contradictory nature of the policies. Now it will be interesting to observe the implementation of "Eat Right" campaign, new FSSAI guidelines and good food tax policy, which should take care of India's' overall growth in terms of health and economy, both.

This activity benefits both the participant and the clinician or researcher by helping youth to communicate how they make sense of the world, honoring different ways of knowing and prompting recollection of coping appraisals and resilience factors.

Participant-generated timelines are a developmentally appropriate and interactive strategy for assessing youth perceptions of their internal strengths. In conjunction with traditional assessments, this strategy may support the identification of malleable targets for intervention in practice with youth who have experienced adversity or mental health challenges.
Participant-generated timelines are a developmentally appropriate and interactive strategy for assessing youth perceptions of their internal strengths. In conjunction with traditional assessments, this strategy may support the identification of malleable targets for intervention in practice with youth who have experienced adversity or mental health challenges.A glycal based expeditious synthesis of novel nucleoside analogues of (+)-anisomycin is reported. Readily available tri-O-benzyl-D-glucal was converted to a partially protected trihydroxypyrrolidine that is used as a common scaffold for the introduction of various nucleobases at the primary hydroxyl centre. Nucleoside analogues possessing all four DNA bases have been synthesized. Selective acetylation at C3 position was carried out with two of these unnatural nucleosides in order to mimic the structure of (+)-anisomycin. Cytotoxicity studies of some of these nucleosides showed that they display weaker activity on HeLa cells than Ara-C.Holstein × Gyr and Holstein are the primary dairy breeds used in tropical systems, but when rearing under pasture, feed intake, behavior, and performance might differ between them. This study aimed to evaluate the voluntary intake, nutrient digestibility, performance, and ingestive behavior of Holstein and Holstein × Gyr (½ Holstein × ½ Gyr) heifers managed in a rotational system of Guinea grass (Panicum maximum Jacq. cv. Mombaça). The experiment was conducted during the summer season throughout four periods of 21 d. Two 8-heifers (four Holstein and four Holstein × Gyr) groups, averaging 258.6 ± 24.79 kg and 157.1 ± 24.99 kg BW, were used. Each group grazed a separate set of 16 paddocks, and all heifers received a concentrate supplement daily. Heifers were weighed at the beginning and end of the experiment. Fecal, forage and concentrate samples were evaluated for their DM, CP, crude fat, ash, NDF, and indigestible NDF. Feeding behavior was evaluated through 24 h of live observation for 48 h of each experiment, even though the behavior was not markedly different between breeds, rearing young Holstein heifers in tropical pasture conditions is less suitable than Holstein-Gyr because of their lower ADG. Therefore, this management condition seems appropriate for Holstein × Gyr but inappropriate for Holstein dairy heifers.Short-term nutrient restrictions can occur naturally in extensive beef cattle production systems due to low feed quality or availability. The aims of the study were to (1) model the curves of milk yield, plasma non-esterified fatty acids (NEFAs) and β-hydroxybutyrate (BHB) contents of beef cows in response to short nutritional challenges throughout lactation; (2) identify clusters of cows with different response profiles; (3) quantify differences in cows' response between the clusters and lactation stages. Data of BW, body condition score (BCS), milk yield, NEFA, and BHB plasma concentration from 31 adult beef cows (626 ± 48 kg at calving) were used to study the effect of 4-day feed restriction repeated over months 2, 3 and 4 of lactation. On each month, all cows received a single diet calculated to meet the requirements of the average cow 100 % requirements for 4 days (d-4 to d-1, basal period), 55 % requirements on the next 4 days (d0 to d3, restriction period) and 100 % requirements for 4 days (d4 to d7, rhways to respond to and recover from the challenge.Cryoinjury and protein changes are a consequence of cryopreservation and may have a negative impact on sperm quality regarding motility, viability and fertilizing ability. However, potential proteomic changes in rabbit semen throughout the cryopreservation process have never been previously investigated. The aim of the present study was to compare the whole proteome of fresh and cryopreserved rabbit semen (spermatozoa and extracellular fluid), to examine the effects of freeze-thawing on proteins changes in semen. Comparative analysis and identification of proteins was carried out using 2-dimensional difference in-gel electrophoresis coupled with a matrix-assisted laser desorption/ionization mass spectrometry. Proteomic raw data are available via ProteomeXchange with identifier PXD034832 for spermatozoa and PXD034853 for extracellular fluid. Respectively, 107 and 28 proteins differed in abundance in spermatozoa and extracellular fluid between fresh and frozen groups. Most of these proteins were involved in pathways related to energy metabolism and protein quality control under stress conditions, reproductive processes and mechanisms of cell death/survival regulation, resulting in a significant decrease of motility and viability of post-thawing rabbit sperm and its potential fertilizing ability. These results broaden the understanding of the effects of cryopreservation on rabbit semen and represent a new starting point for the development of improved freezing procedures.l-carnitine is a well-known an antioxidant that enhanced lipid metabolism. Therefore, this study investigated the influence of supplementing l-carnitine (LC) to in vitro culture medium on preimplantation development, quality, cryotolerance and transcription profile of candidate genes. Following in vitro fertilization, embryos at zygote stage were cultured with medium supplemented with LC at 1.5 mM and fetal calf serum (FCS) at 0, 2.5, 5, 7.5 and 10% of the CR1-aa culture media. Intracellular quality of produced embryos was measured using different fluorescent stains that measured reactive oxygen species (ROS), lipid and mitochondria intensities. In addition, total cell number and total apoptotic cells were counted per embryo. Quantitative expression of candidate genes was conducted to find out molecular response of embryos after treatment. Moreover, vitrification was done at day 8 of preimplantation development to evaluate post-thaw embryo viability. The results indicated improved blastocyst formation rate atd under low FCS (2.5% and 5%) combined with LC supplementation. On the other hand, genes regulating lipogenesis were down-regulated (ACSL3 and S1PR). It can be concluded that LC is an efficient culture media supplement when added with FCS at 2.5 and 5% which improved blastocyst development rate and quality. These improvements are due to enhanced utilization of intracellular embryo lipid that subsequently increased cryotolerance through orchestrating genes involved in various activities of bovine embryos.Busulfan (Bus), is an alkylating agent widely used in chemotherapy which has been proven to possess toxic side effects on testicles. This study was carried out to compare the probable treatment effects of resveratrol (Res) or/and l-carnitine (Lca), as strong antioxidants, on the testicular tissue as well as on the level of sex hormones in busulfan-induced azoospermic rat models. A total of 78 adult male rats, were divided into six different experimental groups including 1) Control; 2) Lca + Res; 3) BUS; 4) Bus + Lca; 5) BUS + Res and 6) Bus + Lca + Res. Busulfan was intraperitoneally administered in a single dose (10 mg/kg b.w), while resveratrol (20 mg/kg b.w/day) and l-carnitine (200 mg/kg b.w/day) were orally administered by gavage during 48 consecutive days to the rats. At the end of the experiment in all groups the level of LH, FSH, and testosterone were biochemically analyzed by ELISA and the testicular tissue evaluated histologically using stereological technique. Results showed that Lca or/and Res, increased the body and testis weight, the volume of the testis, interstitial tissue, germinal epithelium, and seminiferous tubule, the number of the different cells of germinal epithelium and the level of testosterone. On the other hand, Lca, Res and their combination decreased the concentration of LH and FSH compared to the group treated with Bus. In conclusion, these results suggested that l-carnitine or/and resveratrol treatment significantly attenuated busulfan -induced changes of the rat reproductive system led to the recovery of both testis and sperm parameters. However, co-administration of L-ca and Res was more effective than their individual treatment. This combination may alleviate the side effects of alkylating drugs, such as busulfan and may be beneficial for spermatogenesis.Vascularization is fundamental to the growth and spread of tumor cells to distant sites. As a consequence, angiogenesis, the sprouting of new blood vessels from existing ones, is a characteristic trait of cancer. In 1971, Judah Folkman postulated that tumour growth is angiogenesis dependent and that by cutting off blood supply, a neoplastic lesion could be potentially starved into remission. Decades of research have been devoted to understanding the role that vascular endothelial growth factor (VEGF) plays in tumor angiogenesis, and it has been identified as a significant pro-angiogenic factor that is frequently overexpressed within a tumor mass. https://www.selleckchem.com/products/alexidine-dihydrochloride.html Today, anti-VEGF drugs such as Sunitinib, Sorafenib, Axitinib, Tanibirumab, and Ramucirumab have been approved for the treatment of advanced and metastatic cancers. However, anti-angiogenic therapy has turned out to be more complex than originally thought. The failure of this therapeutic option calls for a reevaluation of VEGF as the major target in anti-angiogenic cancer therapy. The call for reassessment is based on two rationales first, tumour blood vessels are abnormal, disorganized, and leaky; this not only prevents optimal drug delivery but it also promotes hypoxia and metastasis; secondly, tumour growth or regrowth might be blood vessel dependent and not angiogenesis dependent as tumour cells can acquire blood vessels via non-angiogenic mechanisms. Therefore, a critical assessment of VEGF, VEGFRs, and their inhibitors could glean newer options such as repurposing anti-VEGF drugs as vascular normalizing agents to enhance drug delivery of immune checkpoint inhibitors.Peer relations inform consumption practices that shape both alcohol use and prescription drug misuse. Integrating studies on pharmaceutical cognitive enhancement with research on consumptive based edgework, this paper examines the role of psychostimulant medications in resolving contradictory aspects of contemporary peer building processes. Drawing on qualitative interviews (n = 162) from a U.S. based study on the context of young adult prescription drug misuse, we demonstrate how medical resources are incorporated into peer bonding rituals in order to enhance consumptive capacity, reduce social risks, and facilitate the accumulation of relational capital. These findings highlight the paradoxical and problematic health ramifications of consumptive based peer bonding practices as well as how psycho-stimulant medications may compound those issues in unintended ways.