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02/04/2025


The skin is home to a collection of fibroblastic cell types from varying embryonic origins. https://www.selleckchem.com/products/esi-09.html These varying fibroblastic lineages display unique genetic programs and in vivo functions. Studying the diversity of fibroblastic cells is emerging as an important area for cutaneous biology, wound repair and regenerative medicine. In this mini-review we discuss the distinct embryonic origins, microenvironments, and transcriptomic profiles of fibroblastic lineages, and how these varying lineages shape the skin's wound response across injury depths, anatomic locations, and developmental time to promote either scarring or regeneration. We outline how the development of single cell sequencing has led to our improved understanding of fibroblastic lineages at the molecular level and discuss existing challenges and future outlook on developing regenerative therapies that are based on this emerging field of eclectic fibroblasts.
Acute Respiratory Distress Syndrome (ARDS) is an infrequent, yet morbid inflammatory complication in injury victims. With the current project we sought to estimate trends in incidence, determine outcomes, and identify risk factors for ARDS and related mortality.

The national Trauma Quality Improvement Program dataset (2010-2014) was queried. Demographics, injury characteristics and outcomes were compared between patients who developed ARDS and those who did not. Logistic regression models were fitted for the development of ARDS and mortality respectively, adjusting for relevant confounders.

In the studied 808,195 TQIP patients, incidence of ARDS decreased over the study years (3-1.1%, p < 0.001), but related mortality increased (18.-21%, p = 0.001). ARDS patients spent an additional 14.7 ± 10.3 days in the hospital, 9.7 ± 7.9 in the ICU, and 6.6 ± 9.4 on mechanical ventilation (all p < 0.001). Older age, male gender, African American race increased risk for ARDS. Age, male gender, lower GCS and higher ISS also increased mortality risk among ARDS patients. Several pre-existing comorbidities including chronic alcohol use, diabetes, smoking, and respiratory disease also increased risk.

Although the incidence of ARDS after trauma appears to be declining, mortality is on the rise.
Although the incidence of ARDS after trauma appears to be declining, mortality is on the rise.Over the last years, technological innovation in Radiotherapy (RT) led to the introduction of Magnetic Resonance-guided RT (MRgRT) systems. Due to the higher soft tissue contrast compared to on-board CT-based systems, MRgRT is expected to significantly improve the treatment in many situations. MRgRT systems may extend the management of inter- and intra-fraction anatomical changes, offering the possibility of online adaptation of the dose distribution according to daily patient anatomy and to directly monitor tumor motion during treatment delivery by means of a continuous cine MR acquisition. Online adaptive treatments require a multidisciplinary and well-trained team, able to perform a series of operations in a safe, precise and fast manner while the patient is waiting on the treatment couch. Artificial Intelligence (AI) is expected to rapidly contribute to MRgRT, primarily by safely and efficiently automatising the various manual operations characterizing online adaptive treatments. Furthermore, AI is finding relevant applications in MRgRT in the fields of image segmentation, synthetic CT reconstruction, automatic (on-line) planning and the development of predictive models based on daily MRI. This review provides a comprehensive overview of the current AI integration in MRgRT from a medical physicist's perspective. Medical physicists are expected to be major actors in solving new tasks and in taking new responsibilities their traditional role of guardians of the new technology implementation will change with increasing emphasis on the managing of AI tools, processes and advanced systems for imaging and data analysis, gradually replacing many repetitive manual tasks.Transcranial Magnetic Stimulation (TMS) is used reliably as an alternative method in the treatment of a number of treatment-resistant psychiatric disorders. However, information about the daily practice is limited. In this article, we aim to report and discuss the 10-years results of a clinic that applies TMS to treatment-resistant psychiatric disorders. This naturalistic study is a retrospective review of data routinely collected from patients undergoing TMS between 2010 and 2020. A total of 284 patients with diagnoses of major depressive disorder (MDD), obsessive-compulsive disorder, generalized anxiety disorder, and post-traumatic stress disorder (PTSD) were included in the study. The mean age of the participants was 40.49±12.64 years. In general, when the responses of all patients were examined, 26.1% were evaluated as response, 29.2% as partial response, and 44.7% as inadequate response. It has been determined that MDD responds to treatment better than other disorders. Regardless of the diagnosis, a significant relationship was found between response and age. The multivariate logistic regression analysis suggested that patients with improvement from TMS were less likely to have advanced age and not to have been diagnosed with PTSD. The idea that TMS may be useful for some patients, but not every patient, is supported.COVID-19, and efforts to mitigate its spread, are creating extensive mental health problems. Experts have speculated the mental, economic, behavioral, and psychosocial problems linked to the COVID-19 pandemic may lead to a rise in suicide behavior. However, a quantitative synthesis is needed to reach an overall conclusion regarding the pandemic-suicide link. In the most comprehensive test of the COVID-19-suicidality link to date, we meta-analyzed data from 308,596 participants across 54 studies. Our results suggested increased event rates for suicide ideation (10.81%), suicide attempts (4.68%), and self-harm (9.63%) during the COVID-19 pandemic when considered against event rates from pre-pandemic studies. Moderation analysis indicated younger people, women, and individuals from democratic countries are most susceptible to suicide ideation during the COVID-19 pandemic. Policymakers and helping professionals are advised that suicide behaviors are alarmingly common during the COVID-19 pandemic and vary based upon age, gender, and geopolitics.

The US dollar has long been the world’s dominant currency, but its use as an economic weapon and is sparking global shifts. From sanctions on Russia to China’s push for de-dollarization, the landscape is changing.

Are these sanctions hurting the right people? Could BRICS or Bitcoin challenge the dollar’s supremacy? Dive into the latest interview to explore how economic power plays are reshaping the world order.

https://www.brighteon.com/1aaf5d24-53c8-4132-9a5b-ae530b1c8863

#EconomicPower #USDollar #GlobalEconomy #BRICS #DeDollarization #Bitcoin #Geopolitics #EconomicSanctions #WatchNow

🎥 Watch the full interview at www.brighteon.com/channels/hrreport

The US dollar has long been the world’s dominant currency, but its use as an economic weapon and is sparking global shifts. From sanctions on Russia to China’s push for de-dollarization, the landscape is changing.Are these sanctions hurting the right people? Could BRICS or Bitcoin challenge the dollar’s supremacy? Dive into the latest interview to explore how economic power plays are reshaping the world order.#EconomicPower #USDollar #GlobalEconomy #BRICS #DeDollarization #Bitcoin #Geopolitics #EconomicSanctions #WatchNow🎥 Watch the full interview at www.brighteon.com/channels/hrreport

www.brighteon.com

Dive into the future with us! In this interview by Seth Holehouse, we unravel the seismic shift in the tech world caused by DeepSeek. This free, open-source reasoning model, developed in China, is rewriting the rules and causing a trillion-dollar market cap drop for Nvidia. Why? DeepSeek’s unparalleled ability to perform complex calculations, from chemistry to finance, all offline and without surveillance, is a game changer.

Watch the full interview to understand the intersection of AI, geopolitics, and the future of tech.

https://www.brighteon.com/0473c9f2-0cb6-4a95-a0dd-a203bee8e931

#AIRevolution #DeepSeek #NvidiaShakeup #TechFuture #Geopolitics #FreeAI #MikeAdams #SethHolehouse

🎥 Watch the full interview at www.brighteon.com/channels/hrreport

Dive into the future with us! In this interview by Seth Holehouse, we unravel the seismic shift in the tech world caused by DeepSeek. This free, open-source reasoning model, developed in China, is rewriting the rules and causing a trillion-dollar market cap drop for Nvidia. Why? DeepSeek’s unparalleled ability to perform complex calculations, from chemistry to finance, all offline and without surveillance, is a game changer.Watch the full interview to understand the intersection of AI, geopolitics, and the future of tech.#AIRevolution #DeepSeek #NvidiaShakeup #TechFuture #Geopolitics #FreeAI #MikeAdams #SethHolehouse🎥 Watch the full interview at www.brighteon.com/channels/hrreport

www.brighteon.com

Videos

08/19/2024

In today’s episode of Direct Impact, Rick Sanchez addresses the dangerous consequences of a Ukrainian drone strike on a nuclear power plant. The show then shifts focus to US Ambassador to Japan Rahm Emanuel and British officials boycotting a Nagasaki peace ceremony, revealing tensions over Israel’s actions in Gaza. The episode wraps up with an in-depth discussion between Rick and his guest, Sarah Bils of DD Geopolitics, on the broader implications of the Russia-Ukraine conflict and its global repercussions.

08/05/2024

In this episode of Direct Impact with Rick Sanchez, the focus is on the controversial rise of Kamala Harris within the Democratic Party despite significant opposition. Rick criticizes Harris’s political track record and the party’s apparent determination to promote her candidacy. The episode also touches on the absence of Harris during a critical Israeli Prime Minister visit and the resignation of the head of the US Secret Service amid congressional criticism. The show concludes with a conversation with John Jackman, Host of D.D. Geopolitics with his insight on the current race for president.

07/22/2024

In this episode of Direct Impact with Rick Sanchez, the focus shifts through a range of topics, beginning with a spotlight on Usha Vance, potentially the next second lady of the United States. The episode contrasts her introduction with President Joe Biden’s recent stumble during a speech to the NAACP, where he mistakenly cited a figure unrelated to his policy initiative. The show concludes with an interview with former Pentagon official Michael Maloof about the United States’ standing in geopolitics.

Circles

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Videos

08/19/2024

In today’s episode of Direct Impact, Rick Sanchez addresses the dangerous consequences of a Ukrainian drone strike on a nuclear power plant. The show then shifts focus to US Ambassador to Japan Rahm Emanuel and British officials boycotting a Nagasaki peace ceremony, revealing tensions over Israel’s actions in Gaza. The episode wraps up with an in-depth discussion between Rick and his guest, Sarah Bils of DD Geopolitics, on the broader implications of the Russia-Ukraine conflict and its global repercussions.

08/05/2024

In this episode of Direct Impact with Rick Sanchez, the focus is on the controversial rise of Kamala Harris within the Democratic Party despite significant opposition. Rick criticizes Harris’s political track record and the party’s apparent determination to promote her candidacy. The episode also touches on the absence of Harris during a critical Israeli Prime Minister visit and the resignation of the head of the US Secret Service amid congressional criticism. The show concludes with a conversation with John Jackman, Host of D.D. Geopolitics with his insight on the current race for president.

07/22/2024

In this episode of Direct Impact with Rick Sanchez, the focus shifts through a range of topics, beginning with a spotlight on Usha Vance, potentially the next second lady of the United States. The episode contrasts her introduction with President Joe Biden’s recent stumble during a speech to the NAACP, where he mistakenly cited a figure unrelated to his policy initiative. The show concludes with an interview with former Pentagon official Michael Maloof about the United States’ standing in geopolitics.

06/24/2024

In this episode of ‘Direct Impact,’ Rick Sanchez delves into concerns over Vice President Kamala Harris’s approval ratings amid public perception challenges facing President Biden. The show highlights Russian President Vladimir Putin’s media visibility and diplomatic strategies during his visit to Vietnam. Historian Tarik Cyril Amar also joins the show to provide insights on Russia’s geopolitical moves.

06/19/2024

In this newscast, Rick Sanchez discusses the political challenges faced by Emmanuel Macron in France, noting widespread discontent and the rising popularity of Marine Le Pen ahead of parliamentary elections. Shifting focus to the US, Sanchez critiques President Biden’s apparent struggles with his mental capacity. Finally, Rick is joined by Sarah Bils, co-founder of DD Geopolitics, to discuss Western leaders and their historic meddling across the globe.

Posts

02/04/2025


The skin is home to a collection of fibroblastic cell types from varying embryonic origins. https://www.selleckchem.com/products/esi-09.html These varying fibroblastic lineages display unique genetic programs and in vivo functions. Studying the diversity of fibroblastic cells is emerging as an important area for cutaneous biology, wound repair and regenerative medicine. In this mini-review we discuss the distinct embryonic origins, microenvironments, and transcriptomic profiles of fibroblastic lineages, and how these varying lineages shape the skin's wound response across injury depths, anatomic locations, and developmental time to promote either scarring or regeneration. We outline how the development of single cell sequencing has led to our improved understanding of fibroblastic lineages at the molecular level and discuss existing challenges and future outlook on developing regenerative therapies that are based on this emerging field of eclectic fibroblasts.
Acute Respiratory Distress Syndrome (ARDS) is an infrequent, yet morbid inflammatory complication in injury victims. With the current project we sought to estimate trends in incidence, determine outcomes, and identify risk factors for ARDS and related mortality.

The national Trauma Quality Improvement Program dataset (2010-2014) was queried. Demographics, injury characteristics and outcomes were compared between patients who developed ARDS and those who did not. Logistic regression models were fitted for the development of ARDS and mortality respectively, adjusting for relevant confounders.

In the studied 808,195 TQIP patients, incidence of ARDS decreased over the study years (3-1.1%, p < 0.001), but related mortality increased (18.-21%, p = 0.001). ARDS patients spent an additional 14.7 ± 10.3 days in the hospital, 9.7 ± 7.9 in the ICU, and 6.6 ± 9.4 on mechanical ventilation (all p < 0.001). Older age, male gender, African American race increased risk for ARDS. Age, male gender, lower GCS and higher ISS also increased mortality risk among ARDS patients. Several pre-existing comorbidities including chronic alcohol use, diabetes, smoking, and respiratory disease also increased risk.

Although the incidence of ARDS after trauma appears to be declining, mortality is on the rise.
Although the incidence of ARDS after trauma appears to be declining, mortality is on the rise.Over the last years, technological innovation in Radiotherapy (RT) led to the introduction of Magnetic Resonance-guided RT (MRgRT) systems. Due to the higher soft tissue contrast compared to on-board CT-based systems, MRgRT is expected to significantly improve the treatment in many situations. MRgRT systems may extend the management of inter- and intra-fraction anatomical changes, offering the possibility of online adaptation of the dose distribution according to daily patient anatomy and to directly monitor tumor motion during treatment delivery by means of a continuous cine MR acquisition. Online adaptive treatments require a multidisciplinary and well-trained team, able to perform a series of operations in a safe, precise and fast manner while the patient is waiting on the treatment couch. Artificial Intelligence (AI) is expected to rapidly contribute to MRgRT, primarily by safely and efficiently automatising the various manual operations characterizing online adaptive treatments. Furthermore, AI is finding relevant applications in MRgRT in the fields of image segmentation, synthetic CT reconstruction, automatic (on-line) planning and the development of predictive models based on daily MRI. This review provides a comprehensive overview of the current AI integration in MRgRT from a medical physicist's perspective. Medical physicists are expected to be major actors in solving new tasks and in taking new responsibilities their traditional role of guardians of the new technology implementation will change with increasing emphasis on the managing of AI tools, processes and advanced systems for imaging and data analysis, gradually replacing many repetitive manual tasks.Transcranial Magnetic Stimulation (TMS) is used reliably as an alternative method in the treatment of a number of treatment-resistant psychiatric disorders. However, information about the daily practice is limited. In this article, we aim to report and discuss the 10-years results of a clinic that applies TMS to treatment-resistant psychiatric disorders. This naturalistic study is a retrospective review of data routinely collected from patients undergoing TMS between 2010 and 2020. A total of 284 patients with diagnoses of major depressive disorder (MDD), obsessive-compulsive disorder, generalized anxiety disorder, and post-traumatic stress disorder (PTSD) were included in the study. The mean age of the participants was 40.49±12.64 years. In general, when the responses of all patients were examined, 26.1% were evaluated as response, 29.2% as partial response, and 44.7% as inadequate response. It has been determined that MDD responds to treatment better than other disorders. Regardless of the diagnosis, a significant relationship was found between response and age. The multivariate logistic regression analysis suggested that patients with improvement from TMS were less likely to have advanced age and not to have been diagnosed with PTSD. The idea that TMS may be useful for some patients, but not every patient, is supported.COVID-19, and efforts to mitigate its spread, are creating extensive mental health problems. Experts have speculated the mental, economic, behavioral, and psychosocial problems linked to the COVID-19 pandemic may lead to a rise in suicide behavior. However, a quantitative synthesis is needed to reach an overall conclusion regarding the pandemic-suicide link. In the most comprehensive test of the COVID-19-suicidality link to date, we meta-analyzed data from 308,596 participants across 54 studies. Our results suggested increased event rates for suicide ideation (10.81%), suicide attempts (4.68%), and self-harm (9.63%) during the COVID-19 pandemic when considered against event rates from pre-pandemic studies. Moderation analysis indicated younger people, women, and individuals from democratic countries are most susceptible to suicide ideation during the COVID-19 pandemic. Policymakers and helping professionals are advised that suicide behaviors are alarmingly common during the COVID-19 pandemic and vary based upon age, gender, and geopolitics.

The US dollar has long been the world’s dominant currency, but its use as an economic weapon and is sparking global shifts. From sanctions on Russia to China’s push for de-dollarization, the landscape is changing.

Are these sanctions hurting the right people? Could BRICS or Bitcoin challenge the dollar’s supremacy? Dive into the latest interview to explore how economic power plays are reshaping the world order.

https://www.brighteon.com/1aaf5d24-53c8-4132-9a5b-ae530b1c8863

#EconomicPower #USDollar #GlobalEconomy #BRICS #DeDollarization #Bitcoin #Geopolitics #EconomicSanctions #WatchNow

🎥 Watch the full interview at www.brighteon.com/channels/hrreport

The US dollar has long been the world’s dominant currency, but its use as an economic weapon and is sparking global shifts. From sanctions on Russia to China’s push for de-dollarization, the landscape is changing.Are these sanctions hurting the right people? Could BRICS or Bitcoin challenge the dollar’s supremacy? Dive into the latest interview to explore how economic power plays are reshaping the world order.#EconomicPower #USDollar #GlobalEconomy #BRICS #DeDollarization #Bitcoin #Geopolitics #EconomicSanctions #WatchNow🎥 Watch the full interview at www.brighteon.com/channels/hrreport

www.brighteon.com

Dive into the future with us! In this interview by Seth Holehouse, we unravel the seismic shift in the tech world caused by DeepSeek. This free, open-source reasoning model, developed in China, is rewriting the rules and causing a trillion-dollar market cap drop for Nvidia. Why? DeepSeek’s unparalleled ability to perform complex calculations, from chemistry to finance, all offline and without surveillance, is a game changer.

Watch the full interview to understand the intersection of AI, geopolitics, and the future of tech.

https://www.brighteon.com/0473c9f2-0cb6-4a95-a0dd-a203bee8e931

#AIRevolution #DeepSeek #NvidiaShakeup #TechFuture #Geopolitics #FreeAI #MikeAdams #SethHolehouse

🎥 Watch the full interview at www.brighteon.com/channels/hrreport

Dive into the future with us! In this interview by Seth Holehouse, we unravel the seismic shift in the tech world caused by DeepSeek. This free, open-source reasoning model, developed in China, is rewriting the rules and causing a trillion-dollar market cap drop for Nvidia. Why? DeepSeek’s unparalleled ability to perform complex calculations, from chemistry to finance, all offline and without surveillance, is a game changer.Watch the full interview to understand the intersection of AI, geopolitics, and the future of tech.#AIRevolution #DeepSeek #NvidiaShakeup #TechFuture #Geopolitics #FreeAI #MikeAdams #SethHolehouse🎥 Watch the full interview at www.brighteon.com/channels/hrreport

www.brighteon.com

Dive into the fascinating world of advanced tech and geopolitical intrigue!

Timothy Alberino explores the combination of explanations behind mysterious aerial phenomena, suggesting a mix of our own tech, foreign actors, and even UFOs. China, with its rapid advancements in AI and drone technology, is a key player. From drone carriers to over-the-horizon capabilities, China's tech is reshaping the skies.

https://www.brighteon.com/c0e4345a-403f-48c9-ac6d-01cb5d2c8c08

#TechMysteries #ChinaTech #UFOs #Geopolitics #AdvancedDrones #TimothyAlberino #MikeAdams

🎥 Watch the full interview at www.brighteon.com/channels/hrreport

Dive into the fascinating world of advanced tech and geopolitical intrigue!Timothy Alberino explores the combination of explanations behind mysterious aerial phenomena, suggesting a mix of our own tech, foreign actors, and even UFOs. China, with its rapid advancements in AI and drone technology, is a key player. From drone carriers to over-the-horizon capabilities, China's tech is reshaping the skies.#TechMysteries #ChinaTech #UFOs #Geopolitics #AdvancedDrones #TimothyAlberino #MikeAdams 🎥 Watch the full interview at www.brighteon.com/channels/hrreport

www.brighteon.com

01/30/2025

Dive into the fascinating world of advanced tech and geopolitical intrigue!

Timothy Alberino explores the combination of explanations behind mysterious aerial phenomena, suggesting a mix of our own tech, foreign actors, and even UFOs. China, with its rapid advancements in AI and drone technology, is a key player. From drone carriers to over-the-horizon capabilities, China's tech is reshaping the skies.

https://www.brighteon.com/c0e4345a-403f-48c9-ac6d-01cb5d2c8c08

#TechMysteries #ChinaTech #UFOs #Geopolitics #AdvancedDrones #TimothyAlberino #MikeAdams

🎥 Watch the full interview at www.brighteon.com/channels/hrreport

Dive into the fascinating world of advanced tech and geopolitical intrigue!Timothy Alberino explores the combination of explanations behind mysterious aerial phenomena, suggesting a mix of our own tech, foreign actors, and even UFOs. China, with its rapid advancements in AI and drone technology, is a key player. From drone carriers to over-the-horizon capabilities, China's tech is reshaping the skies.#TechMysteries #ChinaTech #UFOs #Geopolitics #AdvancedDrones #TimothyAlberino #MikeAdams 🎥 Watch the full interview at www.brighteon.com/channels/hrreport

www.brighteon.com