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01/21/2025


Since antiquity, specialists have worked to facilitate the communication of hearing impaired individuals, which according to the current literature, is among the disabilities that have the greatest impact on the quality of life. The system by which deaf people communicate is based essentially on sign language and the manual alphabet, employing gestures, and facial and body expressions. Although there is no exact data on how many people communicated through sign language in ancient times, studies show manual alphabets were used by deaf people in Europe in the early 15th century. Perhaps this was a reflection of a significant number of deaf people living throughout Europe at that time and who needed sign language to communicate. In this context, this manuscript, for the first time, demonstrates the renowned Italian Renaissance artist and genius of human anatomy Michelangelo Buonarroti (1475-1564) may have used deaf sign language in the fresco The Crucifixion of Saint Peter [Cappella Paolina, Vatican City, Italy]. This would demonstrate the engagement of one of the greatest Renaissance artists, with a clinical condition that has been studied by numerous health specialists since ancient times.Today, the recovery, study and exposition of archaeological human remains are subjected to new discussions. Human remains preserve a clear record of past life to later generations. These remains, even if dated hundreds or thousands of years ago, maintain their human dignity and force the community to reflect on the ethical issues related to their analysis, curation and display. Such a topic stimulate a continuous dialogue between the different actors of the bioarchaeological/osteoarchaeological/anthropological (physical and forensic) field archaeologists, anthropologists, bioethicists, museum curators and other figures in order to give voice to a broad range of approaches and identify shared paths on the management of human remains that respect human dignity and different cultural values of community. As a "culturally sensitive material", human remains collections must be acquired and handled with respect regardless of their age and legitimacy of provenance. The opening up to disciplines quite far from the expertize of museum curators is an essential prerequisite to increase awareness towards ethical issues and to develop guidelines that take into account the dignity of the person and the cultural values of community to whom human remains belonged. Accordingly, the authors stimulate the increase of the discussion and try to identify solutions sensitive to the issue.During the Middle Ages, Parma, in Northern Italy, undoubtedly represented a landmark for surgical science and practice all around Europe. Around the same period the Salernitan Medical School, already famous since the high Middle Ages, reached its whole scientific role. Due to the importance reached by the School, for centuries several physicians throughout Europe, aiming for an international fame, told they were "Salernitan". One of the most famous examples is represented by Roger Frugardi, or Ruggero Frugardo, or Ruggero da Parma (before 1140 - about 1195), who was widely known as "Rogerius Salernitanus" (Roger of Salerno), meaning that his scientific success was a consequence of the affiliation to the Salernitan Medical School. Roger wrote an important book, the "Practica Chirurgiae" (Surgical Practice), also known as "Rogerina", edited and published by his pupil Guido "the young" of Arezzo. It was the first Handbook of Surgery in the post-Latin Europe, containing important innovations, such as the very first description of a thyroidectomy, thus influencing surgical practice until late Renaissance. The Roger's pupil Rolando dei Capelluti was the successor and extensor of his Master's work. In his work he particularly developed the cranial surgery and the study of neurological diseases (e.g., epilepsy or mania). His masterwork, known as "Rolandina", also influenced European surgery for centuries.Nobel Prizes are prestigious world awards attributed for intellectual achievements. There are six prizes awarded each year from a fund bequeathed by the Swedish industrialist Alfred Bernhard Nobel (1833-1896). Each Prize consists of a diploma, a gold medal and a sum of money and it may be attributed to one, two or three different persons. The Nobel Prize in Physiology or Medicine is regarded as the most relevant scientific acknowledgement in the biomedical area and is annually assigned to the living researcher, or researchers, who has/have more contributed to progress in this field. Nobel Prizes in Medicine so far attributed are 110 with 219 medicine laureates, of whom the youngest was 32 years old and the oldest 87. Twelve women have been awarded the prize and nobody has been awarded it more than once. The Nobel Prize in Physiology or Medicine is fundamental and its more than secular history certifies this. Generations of distinguished scientists have rightly been awarded it for discoveries, demonstrations and applications of paramount relevance. https://www.selleckchem.com/products/m344.html The geographical distribution and the number of scholars appointed with the Nobel Prize in Medicine, the areas of health sciences and biomedical research related to the awards and the motivations of the annually attributed Nobel Prize in Medicine provide a complete and stimulating historical and epistemological panorama of medicine, biology and health sciences in the course of the XX and XXI centuries.
Job burnout is the psychosocial judgement of the physical and psychological tiredness result to the prolongation emotional pressure associated to the job. This study purposed to assess burnout prevalence among Italian nurses who worked in different contexts.

Burnout was assessed by the Italian version of the 22-item Maslach Burnout Inventory Human Service Survey. Data were collected in July and August 2019.

300 Italian nurses voluntary participated in this study. Questionnaire were administered by Google Forms application, were all Italian nurses could participate.

Emotional Exhaustion (EE) is the most representative dimension of burnout. This outcome becomes more acute with greater age and seniority in the position, due to the stress and monotony encountered and/or job dissatisfaction.
Emotional Exhaustion (EE) is the most representative dimension of burnout. This outcome becomes more acute with greater age and seniority in the position, due to the stress and monotony encountered and/or job dissatisfaction.

10/24/2024


Introduction

The shape of Jesus associated with Nazareth, pivotal within the Christian faith, captivates both scholars and adherents. While typically the Bible remains the principal repository of information concerning Jesus, numerous non-Christian resources and historians also make mention associated with him. This blog page delves into these types of external references, giving insights into the historic milieu surrounding Jesus. Here, we make a comprehensive set of sources and historians beyond the Holy bible that acknowledge the presence of Jesus.

Flavius Josephus (c. 37 : c. 100 AD)

Flavius Josephus, the Jewish historian creating in the past due 1st century ADVERTISEMENT, includes a mention of the Christ in his work "Antiquities of the Jews. " Even though the authenticity of the passage known as the Testimonium Flavianum is definitely disputed, it however provides valuable glimpses into Jesus' existence and crucifixion.

Quotation: "About this time there lived Jesus, an intelligent man, when indeed one really need to call him a man. Regarding he was one who performed surprising deeds and had been a teacher of such people because accept the reality gladly. "

Tacitus (c. 56 – c. 120 AD)

The Roman historian Tacitus, in the work "Annals" composed around 116 AD, mentions Jesus whilst narrating the persecution of Christians beneath Emperor Nero. Tacitus corroborates facets of the Gospel accounts simply by referencing Jesus' performance by Pontius Pilate.

Quote: "Christus, by whom the name had its origin, endured the extreme penalty during the rule of Tiberius at the hands associated with one of our procurators, Pontius Pilatus. inch

Pliny the Youthful (c. 61 ~ c. 113 AD)

In a notice to Emperor Trajan circa 112 AD, Pliny the Younger, a Roman chief excutive, describes early Religious practices and their reverence for Christ. His correspondence offers evidence of Jesus' influence on nascent Christian communities.

Quotation: "They were in the habit of getting together with on a selected fixed day before it absolutely was light, whenever they sang inside alternate verses a hymn to Christ, as to some sort of god, and destined themselves by a new solemn oath, not to any wicked deeds, but never to commit any fraud, theft or perhaps adultery, never to falsify their phrase, nor deny a new trust when that they should be asked to deliver it up. inch

Suetonius (c. 69 ~ c. 122 AD)

Suetonius, another Roman historian, refers to be able to disturbances one of the Jews in Rome in the course of the reign involving Emperor Claudius. Though not an immediate mention of Jesus, the turmoil attributed to be able to "Chrestus" reflects the particular tensions stemming through early Christian thinking.

Quote: "As typically the Jews were helping to make constant disturbances in the instigation regarding Chrestus, he [Claudius] removed them from Ancient rome. "

Lucian involving Samosata (c. 125 – after 180 AD)

The Ancient greek language satirist Lucian of Samosata, in their work "The Driving of Peregrinus, " indirectly alludes in order to Jesus and earlier Christians. Despite the critical portrayal, this underscores the expansion of Christianity in antiquity.

Quote: "The Christians, you find out, worship a man to be able to this day—the famous personage who presented their novel rites, and was crucified on that account. "

Mara tavern Serapion (uncertain dates)

Mara bar Serapion, a Stoic thinker, mentions the Jews' execution of their "wise king" found in a letter to be able to his son. Whilst subject to controversy, some scholars interpret this as a great oblique reference to Jesus.

Quote: "What advantage did the particular Jews gain by executing their wise king? It had been only after that their own kingdom was abolished. "

Thallus (uncertain dates)

Although a lot of his work is lost, Thallus, some sort of 1st-century historian, is usually cited by later writers like Julius Africanus. Thallus's purported explanation for the darkness during Jesus' crucifixion indirectly attests to Jesus' living.

Quote: The estimate from Thallus is definitely not directly available as his performs are mostly dropped, but Julius Africanus, a later historian, references Thallus's make an effort to explain the night during Jesus' crucifixion.

Celsus (2nd millennium AD)

Celsus, a Greek philosopher and even critic of Christianity, is chiefly known through the writings of Origen. Despite https://light-for-the-children-orphanage.webflow.io/ , Celsus provides observations into early Christian beliefs and methods.

Quote: "Jesus had are derived from a village in Judea, in addition to was the son of a bad Jewess who gained her living by simply the work involving her hands. "

Conclusion

The sources to Jesus in non-Christian sources and even by historians beyond the Bible furnish powerful corroborative evidence of his existence plus the early effect of Christianity. Even though varying in more detail plus perspective, these records collectively enrich the understanding of Jesus' historical significance and the diffusion of Christianity in antiquity.

09/27/2024


1490-1562) portrayed the never-ending cycle regarding frescoes involving "The Interest regarding Christ". From the central solar panel, "The Crucifixion" among the tortures involving God, the sponge-bearer, exhibits a big goiter along with other signs and symptoms of hypothyroidism (macroglossia, expressionless confront, and also puffiness around the eyes), confirming that the Renaissance musicians frequently manifested sinful as well as incredible individuals because afflicted with hypothyroid conditions.Ivan Mestrovic (1883-1962), a Croatian sculptor along with architect, described his or her good friend Marija Banac (born Racic) which has a goiter. The lady died through virus within 1918 throughout Ancient rome, simply couple of days in addition to the girl close friend Edi Racic and his awesome fiancée. Inside the sad recollection from the Racic family members that will gone away within the break open of your awful crisis, Mestrovic created a new church along with mausoleum in Cavtat in close proximity to Dubrovnik. Sensitized diseases are among the most common along with crucial ailments that will exert unsafe outcomes about children's well being. Your frequency regarding hypersensitive diseases when they are young will be slowly increasing worldwide throughout recent decades. Recognized causes of these kind of diseases incorporate anomalous immune system reactions along with sensitive inflamation related side effects, though the causes of sensitized diseases when they are young are generally intricate. PubMed, Cochrane Library, Embase and also Web associated with Science were searched for posts centering on enviromentally friendly exposure during pregnancy along with the chance of child years sensitive diseases, which includes symptoms of asthma and also atopic eczema, along with the possible root system. Regarding ecological elements, sensitized conditions in childhood tend to be strongly related to environment substance exposure in pregnancy, such as bisphenols, phthalates acid solution esters, perfluorochemicals, polybrominated diphenyl ethers, as well as polychlorinated biphenyls. Even so, sensitive ailments in early childhood will also be tightly connected with maternal diet eating routine, mother's intake of medications, including acetylsalicylic chemical p (discomfort), paracetamol and anti-biotics, as well as mother's way of life. A number of unsafe environment aspects when pregnant may result in the particular interruption from the aim of associate To cellular material (Th1/Th2), cytokines and also immunoglobulins and might switch on allergy symptoms, be a catalyst for sensitive conditions during the child years.Many unsafe environment https://www.selleckchem.com/products/epz-6438.html aspects during pregnancy can lead to your disturbance with the function of helper Big t tissue (Th1/Th2), cytokines along with immunoglobulins and could activate hypersensitive reactions, resulted in allergic ailments in the course of the child years.Sweet walking stick syndrome is definitely an underappreciated complications described within bariatric patients pursuing Roux-en-Y abdominal get around. This comes from the overly extended window blind afferent Roux arm or leg at the gastrojejunostomy that can result in foods build up.

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01/21/2025


Since antiquity, specialists have worked to facilitate the communication of hearing impaired individuals, which according to the current literature, is among the disabilities that have the greatest impact on the quality of life. The system by which deaf people communicate is based essentially on sign language and the manual alphabet, employing gestures, and facial and body expressions. Although there is no exact data on how many people communicated through sign language in ancient times, studies show manual alphabets were used by deaf people in Europe in the early 15th century. Perhaps this was a reflection of a significant number of deaf people living throughout Europe at that time and who needed sign language to communicate. In this context, this manuscript, for the first time, demonstrates the renowned Italian Renaissance artist and genius of human anatomy Michelangelo Buonarroti (1475-1564) may have used deaf sign language in the fresco The Crucifixion of Saint Peter [Cappella Paolina, Vatican City, Italy]. This would demonstrate the engagement of one of the greatest Renaissance artists, with a clinical condition that has been studied by numerous health specialists since ancient times.Today, the recovery, study and exposition of archaeological human remains are subjected to new discussions. Human remains preserve a clear record of past life to later generations. These remains, even if dated hundreds or thousands of years ago, maintain their human dignity and force the community to reflect on the ethical issues related to their analysis, curation and display. Such a topic stimulate a continuous dialogue between the different actors of the bioarchaeological/osteoarchaeological/anthropological (physical and forensic) field archaeologists, anthropologists, bioethicists, museum curators and other figures in order to give voice to a broad range of approaches and identify shared paths on the management of human remains that respect human dignity and different cultural values of community. As a "culturally sensitive material", human remains collections must be acquired and handled with respect regardless of their age and legitimacy of provenance. The opening up to disciplines quite far from the expertize of museum curators is an essential prerequisite to increase awareness towards ethical issues and to develop guidelines that take into account the dignity of the person and the cultural values of community to whom human remains belonged. Accordingly, the authors stimulate the increase of the discussion and try to identify solutions sensitive to the issue.During the Middle Ages, Parma, in Northern Italy, undoubtedly represented a landmark for surgical science and practice all around Europe. Around the same period the Salernitan Medical School, already famous since the high Middle Ages, reached its whole scientific role. Due to the importance reached by the School, for centuries several physicians throughout Europe, aiming for an international fame, told they were "Salernitan". One of the most famous examples is represented by Roger Frugardi, or Ruggero Frugardo, or Ruggero da Parma (before 1140 - about 1195), who was widely known as "Rogerius Salernitanus" (Roger of Salerno), meaning that his scientific success was a consequence of the affiliation to the Salernitan Medical School. Roger wrote an important book, the "Practica Chirurgiae" (Surgical Practice), also known as "Rogerina", edited and published by his pupil Guido "the young" of Arezzo. It was the first Handbook of Surgery in the post-Latin Europe, containing important innovations, such as the very first description of a thyroidectomy, thus influencing surgical practice until late Renaissance. The Roger's pupil Rolando dei Capelluti was the successor and extensor of his Master's work. In his work he particularly developed the cranial surgery and the study of neurological diseases (e.g., epilepsy or mania). His masterwork, known as "Rolandina", also influenced European surgery for centuries.Nobel Prizes are prestigious world awards attributed for intellectual achievements. There are six prizes awarded each year from a fund bequeathed by the Swedish industrialist Alfred Bernhard Nobel (1833-1896). Each Prize consists of a diploma, a gold medal and a sum of money and it may be attributed to one, two or three different persons. The Nobel Prize in Physiology or Medicine is regarded as the most relevant scientific acknowledgement in the biomedical area and is annually assigned to the living researcher, or researchers, who has/have more contributed to progress in this field. Nobel Prizes in Medicine so far attributed are 110 with 219 medicine laureates, of whom the youngest was 32 years old and the oldest 87. Twelve women have been awarded the prize and nobody has been awarded it more than once. The Nobel Prize in Physiology or Medicine is fundamental and its more than secular history certifies this. Generations of distinguished scientists have rightly been awarded it for discoveries, demonstrations and applications of paramount relevance. https://www.selleckchem.com/products/m344.html The geographical distribution and the number of scholars appointed with the Nobel Prize in Medicine, the areas of health sciences and biomedical research related to the awards and the motivations of the annually attributed Nobel Prize in Medicine provide a complete and stimulating historical and epistemological panorama of medicine, biology and health sciences in the course of the XX and XXI centuries.
Job burnout is the psychosocial judgement of the physical and psychological tiredness result to the prolongation emotional pressure associated to the job. This study purposed to assess burnout prevalence among Italian nurses who worked in different contexts.

Burnout was assessed by the Italian version of the 22-item Maslach Burnout Inventory Human Service Survey. Data were collected in July and August 2019.

300 Italian nurses voluntary participated in this study. Questionnaire were administered by Google Forms application, were all Italian nurses could participate.

Emotional Exhaustion (EE) is the most representative dimension of burnout. This outcome becomes more acute with greater age and seniority in the position, due to the stress and monotony encountered and/or job dissatisfaction.
Emotional Exhaustion (EE) is the most representative dimension of burnout. This outcome becomes more acute with greater age and seniority in the position, due to the stress and monotony encountered and/or job dissatisfaction.

10/24/2024


Introduction

The shape of Jesus associated with Nazareth, pivotal within the Christian faith, captivates both scholars and adherents. While typically the Bible remains the principal repository of information concerning Jesus, numerous non-Christian resources and historians also make mention associated with him. This blog page delves into these types of external references, giving insights into the historic milieu surrounding Jesus. Here, we make a comprehensive set of sources and historians beyond the Holy bible that acknowledge the presence of Jesus.

Flavius Josephus (c. 37 : c. 100 AD)

Flavius Josephus, the Jewish historian creating in the past due 1st century ADVERTISEMENT, includes a mention of the Christ in his work "Antiquities of the Jews. " Even though the authenticity of the passage known as the Testimonium Flavianum is definitely disputed, it however provides valuable glimpses into Jesus' existence and crucifixion.

Quotation: "About this time there lived Jesus, an intelligent man, when indeed one really need to call him a man. Regarding he was one who performed surprising deeds and had been a teacher of such people because accept the reality gladly. "

Tacitus (c. 56 – c. 120 AD)

The Roman historian Tacitus, in the work "Annals" composed around 116 AD, mentions Jesus whilst narrating the persecution of Christians beneath Emperor Nero. Tacitus corroborates facets of the Gospel accounts simply by referencing Jesus' performance by Pontius Pilate.

Quote: "Christus, by whom the name had its origin, endured the extreme penalty during the rule of Tiberius at the hands associated with one of our procurators, Pontius Pilatus. inch

Pliny the Youthful (c. 61 ~ c. 113 AD)

In a notice to Emperor Trajan circa 112 AD, Pliny the Younger, a Roman chief excutive, describes early Religious practices and their reverence for Christ. His correspondence offers evidence of Jesus' influence on nascent Christian communities.

Quotation: "They were in the habit of getting together with on a selected fixed day before it absolutely was light, whenever they sang inside alternate verses a hymn to Christ, as to some sort of god, and destined themselves by a new solemn oath, not to any wicked deeds, but never to commit any fraud, theft or perhaps adultery, never to falsify their phrase, nor deny a new trust when that they should be asked to deliver it up. inch

Suetonius (c. 69 ~ c. 122 AD)

Suetonius, another Roman historian, refers to be able to disturbances one of the Jews in Rome in the course of the reign involving Emperor Claudius. Though not an immediate mention of Jesus, the turmoil attributed to be able to "Chrestus" reflects the particular tensions stemming through early Christian thinking.

Quote: "As typically the Jews were helping to make constant disturbances in the instigation regarding Chrestus, he [Claudius] removed them from Ancient rome. "

Lucian involving Samosata (c. 125 – after 180 AD)

The Ancient greek language satirist Lucian of Samosata, in their work "The Driving of Peregrinus, " indirectly alludes in order to Jesus and earlier Christians. Despite the critical portrayal, this underscores the expansion of Christianity in antiquity.

Quote: "The Christians, you find out, worship a man to be able to this day—the famous personage who presented their novel rites, and was crucified on that account. "

Mara tavern Serapion (uncertain dates)

Mara bar Serapion, a Stoic thinker, mentions the Jews' execution of their "wise king" found in a letter to be able to his son. Whilst subject to controversy, some scholars interpret this as a great oblique reference to Jesus.

Quote: "What advantage did the particular Jews gain by executing their wise king? It had been only after that their own kingdom was abolished. "

Thallus (uncertain dates)

Although a lot of his work is lost, Thallus, some sort of 1st-century historian, is usually cited by later writers like Julius Africanus. Thallus's purported explanation for the darkness during Jesus' crucifixion indirectly attests to Jesus' living.

Quote: The estimate from Thallus is definitely not directly available as his performs are mostly dropped, but Julius Africanus, a later historian, references Thallus's make an effort to explain the night during Jesus' crucifixion.

Celsus (2nd millennium AD)

Celsus, a Greek philosopher and even critic of Christianity, is chiefly known through the writings of Origen. Despite https://light-for-the-children-orphanage.webflow.io/ , Celsus provides observations into early Christian beliefs and methods.

Quote: "Jesus had are derived from a village in Judea, in addition to was the son of a bad Jewess who gained her living by simply the work involving her hands. "

Conclusion

The sources to Jesus in non-Christian sources and even by historians beyond the Bible furnish powerful corroborative evidence of his existence plus the early effect of Christianity. Even though varying in more detail plus perspective, these records collectively enrich the understanding of Jesus' historical significance and the diffusion of Christianity in antiquity.

09/27/2024


1490-1562) portrayed the never-ending cycle regarding frescoes involving "The Interest regarding Christ". From the central solar panel, "The Crucifixion" among the tortures involving God, the sponge-bearer, exhibits a big goiter along with other signs and symptoms of hypothyroidism (macroglossia, expressionless confront, and also puffiness around the eyes), confirming that the Renaissance musicians frequently manifested sinful as well as incredible individuals because afflicted with hypothyroid conditions.Ivan Mestrovic (1883-1962), a Croatian sculptor along with architect, described his or her good friend Marija Banac (born Racic) which has a goiter. The lady died through virus within 1918 throughout Ancient rome, simply couple of days in addition to the girl close friend Edi Racic and his awesome fiancée. Inside the sad recollection from the Racic family members that will gone away within the break open of your awful crisis, Mestrovic created a new church along with mausoleum in Cavtat in close proximity to Dubrovnik. Sensitized diseases are among the most common along with crucial ailments that will exert unsafe outcomes about children's well being. Your frequency regarding hypersensitive diseases when they are young will be slowly increasing worldwide throughout recent decades. Recognized causes of these kind of diseases incorporate anomalous immune system reactions along with sensitive inflamation related side effects, though the causes of sensitized diseases when they are young are generally intricate. PubMed, Cochrane Library, Embase and also Web associated with Science were searched for posts centering on enviromentally friendly exposure during pregnancy along with the chance of child years sensitive diseases, which includes symptoms of asthma and also atopic eczema, along with the possible root system. Regarding ecological elements, sensitized conditions in childhood tend to be strongly related to environment substance exposure in pregnancy, such as bisphenols, phthalates acid solution esters, perfluorochemicals, polybrominated diphenyl ethers, as well as polychlorinated biphenyls. Even so, sensitive ailments in early childhood will also be tightly connected with maternal diet eating routine, mother's intake of medications, including acetylsalicylic chemical p (discomfort), paracetamol and anti-biotics, as well as mother's way of life. A number of unsafe environment aspects when pregnant may result in the particular interruption from the aim of associate To cellular material (Th1/Th2), cytokines and also immunoglobulins and might switch on allergy symptoms, be a catalyst for sensitive conditions during the child years.Many unsafe environment https://www.selleckchem.com/products/epz-6438.html aspects during pregnancy can lead to your disturbance with the function of helper Big t tissue (Th1/Th2), cytokines along with immunoglobulins and could activate hypersensitive reactions, resulted in allergic ailments in the course of the child years.Sweet walking stick syndrome is definitely an underappreciated complications described within bariatric patients pursuing Roux-en-Y abdominal get around. This comes from the overly extended window blind afferent Roux arm or leg at the gastrojejunostomy that can result in foods build up.

09/12/2024


A simple model that combined these factors showed excellent performance for prediction of functional outcome after 3 years and mortality after 5 and 10 years (c-statistic ~0.90 for all models). Model performance was confirmed after external validation prediction of functional outcome after 3 years (c-statistic 0.89, 95% CI 0.80-0.98) and mortality after 5 years (c-statistic 0.91, 95% CI 0.84-0.99) were comparable to the results in the discovery cohort. These findings help clinicians to estimate a patient's prognosis, irrespective of the specific diagnosis.Semen Ziziphi Spinosae (SZS) has been extensively used in the daily diet as a functional food for neuroprotective health-benefit in China for many years. However, the neuroprotective mechanism of SZS associated with blood-brain barrier (BBB) integrity remains unexplored. The present study suggests SZS could protect against lipopolysaccharide (LPS)-induced BBB dysfunction. Proteomics indicate that 135 proteins in rat brain are significantly altered by SZS. These differentially expressed proteins are mainly clustered into cell-cell adhesion and adherens junctions, which are closely related with BBB integrity. SZS reversed LPS-induces BBB breakdown by activating the FAK-DOCK180-Rac1-WAVE2-Arp3 pathway. Molecular docking between signaling pathway proteins and identified SZS components in rat plasma reveals that 6"'-feruloylspinosin, spinosin, and swertisin strongly binds to signaling proteins at multiple amino acid sites. These novel findings suggest a health benefit of SZS in prevention of cerebral diseases and contributes to the further application of SZS as a functional food.The arylation of carboxylic acid derivatives via Smiles rearrangement has gained great interest in recent years. Both radical and ionic approaches, as well as radical-polar crossover concepts, have been developed. In contrast, a reversed polar-radical crossover approach remains underexplored. Here we report a simple, efficient and scalable method for the preparation of sterically hindered and valuable α-quaternary amides via a polar-radical crossover-enolate oxidation-aryl migration pathway. A variety of easily accessible N-alkyl and N-arylsulfonamides are reacted with disubstituted ketenes to give the corresponding amide enolates, which undergo upon single electron transfer oxidation, a 1,4-aryl migration, desulfonylation, hydrogen atom transfer cascade to provide α-quaternary amides in good to excellent yields. Various mono- and di-substituted heteroatom-containing and polycyclic arenes engage in the aryl migration reaction. Functional group tolerance is excellent and substrates as well as reagents are readily available rendering the method broadly applicable.The fundamental goal of artificial intelligence (AI) is to mimic the core cognitive activities of human. Despite tremendous success in the AI research, most of existing methods have only single-cognitive ability. To overcome this limitation and take a solid step towards artificial general intelligence (AGI), we develop a foundation model pre-trained with huge multimodal data, which can be quickly adapted for various downstream cognitive tasks. To achieve this goal, we propose to pre-train our foundation model by self-supervised learning with weak semantic correlation data crawled from the Internet and show that promising results can be obtained on a wide range of downstream tasks. Particularly, with the developed model-interpretability tools, we demonstrate that strong imagination ability is now possessed by our foundation model. We believe that our work makes a transformative stride towards AGI, from our common practice of "weak or narrow AI" to that of "strong or generalized AI".The melting of the cryosphere is among the most conspicuous consequences of climate change, with impacts on microbial life and related biogeochemistry. However, we are missing a systematic understanding of microbiome structure and function across cryospheric ecosystems. Here, we present a global inventory of the microbiome from snow, ice, permafrost soils, and both coastal and freshwater ecosystems under glacier influence. Combining phylogenetic and taxonomic approaches, we find that these cryospheric ecosystems, despite their particularities, share a microbiome with representatives across the bacterial tree of life and apparent signatures of early and constrained radiation. In addition, we use metagenomic analyses to define the genetic repertoire of cryospheric bacteria. Our work provides a reference resource for future studies on climate change microbiology.The natural aging process as well as many age-related diseases is associated with impaired metabolic adaptation and declined ability to cope with stress. As major causes of disability and morbidity during the aging process, brain disorders, including psychiatric and neurodegenerative disorders, are likely to increase across the globe in the future decades. This narrative review investigates the link among exercise and brain disorders, aging, and inflammatory biomarkers, along with the function of brain-derived neurotrophic factor. For this study, related manuscript from all databases, Google scholar, Scopus, PubMed, and ISI were assessed. Also, in the search process, the keywords of exercise, neurodegeneration, neurotrophin, mitochondrial dysfunction, and aging were used. Mitochondrial abnormality increases neuronal abnormality and brain disease during the aging process. Stress and inflammatory factors caused by lifestyle and aging also increase brain disorders. Evidences suggest that exercise, as a noninvasive treatment strategy, has antioxidant effects and can reduce neuronal lesions. Brain-derived neurotrophic factor expression following the exercise can reduce brain symptoms; however, careful consideration should be given to a number of factors affecting the results.
The aim of the present study was to investigate how potentially inappropriate medication usage and anti-dementia drug use change from 3 years prior to, up until 3 years post-diagnosis of major neurocognitive disorders among older people living in Sweden.

People registered in the Swedish registry for cognitive/dementia disorders from 1 July, 2008 to 31 December, 2017, and aged 68 years or older at diagnosis, were included (n = 67,226). Data were combined with the Swedish Prescribed Drug Registry to obtain information about drugs collected in 6-month periods at Swedish pharmacies from 3 years pre-diagnosis until 3 years post-diagnosis. Potentially inappropriate medications were identified according to Swedish national guidelines. A generalised estimating equation regression model and estimated marginal means were used.

Of the 67,226 people included in the study population, 59.2% were women and the mean age ± standard deviation was 81.5 ± 6.4 years, 47.0% lived together with a spouse or partner, and 88.9% ed and was significantly lower post-diagnosis of major neurocognitive disorders, except for antipsychotics. This indicates that potentially inappropriate medication use should be noticed and reviewed among all older people. The small decrease in the prevalence of anticholinergic drug users and the increasing proportions of people using antipsychotic drugs post-diagnosis are of special concern because of the adverse drug reactions associated with these types of potentially inappropriate medications. Consequently, it is important to identify and regularly question anticholinergic and antipsychotic drug treatment to prevent unnecessary and serious adverse drug reactions among a vulnerable group of people.Skulls were frequently depicted in seventeenth-century Dutch still-life paintings. Skulls were interpreted as symbols of vanitas-meaning the evanescence of life-but their morphological features have received little attention. This study analyzed a skull with abnormal tumors in a seventeenth-century Dutch still-life painting by a renowned artist, Edwaert Collier (ca. 1642-1708), from anatomical, forensic, and pathological perspectives. https://www.selleckchem.com/ The morphology of the cranium and teeth indicated that the skull likely belonged to a middle-aged female. We carefully diagnosed the abnormal masses as multiple osteomas on the skull and left femur, based on clinical studies and paleopathological literature, which reported lesions with a similar appearance to those observed in Collier's work. Furthermore, detailed observations of the cranial sutures and epiphyses of the long bones in his paintings revealed that the artist may have selected bones with a morphology that was suitable for the subject of vanitas. Collier repeatedly depicted the skull with metopism, the rare condition of having a persistent metopic suture in adulthood. A skull with a metopic suture is called Kreuzschädel, meaning the cross skull, because it forms a cruciform by connecting with the sagittal and coronal sutures. The artist might have chosen skulls with metopic sutures, which is reminiscent of the crucifixion of Christ, as an appropriate motif for the vanitas painting. This paper argues that anatomical analysis could explain the hidden meaning of the painting and disclose the fascinating collaborations between anatomy and art in the seventeenth-century Dutch Republic.
Outdoor air pollution, including ozone (O
) pollution, and childhood family environments may interact and impact asthma exacerbations in children. Previous epidemiology studies have primarily focused on stress in the home, rather than support, and whether psychosocial factors modify the association between pollution and health outcomes, rather than whether pollution exposure modifies associations between psychosocial factors and health outcomes.

Data from the cross-sectional 2003 representative, population-based California Health Interview Survey were linked with air quality monitoring data on O
pollution from the California Air Resources Board. Adolescents(N = 209) ages 12-17 who reported an asthma diagnosis and lived within 5 mi of the nearest air monitoring station had linked O
data for a 12-month period preceding the survey interview date. Adolescents reported perceived available support from an adult at home and frequency of asthma symptoms.

In unadjusted models, for adolescents living in highure assessments, comprehensive family environment assessments, and longitudinal follow-up of asthma exacerbations over time.
Traditional face-to-face cognitive behavioural therapy (CBT) has been successful at reducing fear of falling (FOF) in older people but can be labour-intensive and costly. Online CBT has been suggested as a cost-effective alternative but has not yet been tested in the context of FOF. This study evaluates the effectiveness of a readily available, self-guided and generalised online CBT program (myCompass) on reducing FOF in older people.

Fifty community-dwelling older people with FOF received a paper-based health education program, and half were randomly assigned to receive three selected modules from myCompass for 6weeks. The primary outcome was feared consequences of falling at 6weeks. Secondary outcomes were concern about falling, balance confidence, activity avoidance, physical activity, exercise self-efficacy, health literacy and mental health at 6/26/52weeks and falls incidence at 12months.

All intervention participants completed at least 2-out-of-3 myCompass modules. There was a significant main effect of time on feared consequences of falling (Cohen's f = 0.

09/09/2024


Throughout history, art has served as a powerful medium for expressing spirituality and conveying the stories of faith. Among the most revered figures in religious art is Jesus Christ, whose images have inspired countless generations. From the serene and humble portrayal of His birth to the triumphant representations of His resurrection, depictions of Jesus capture the essence of His teachings and the profound impact He has had on humanity.

As we explore the diverse array of Jesus images, we find that each interpretation offers a glimpse into the multifaceted nature of His character and mission. From Jesus Easter images that celebrate His victory over death to Good Morning Jesus images that invite a sense of comfort and connection, the artistry surrounding His life is rich and varied. These visual representations not only help believers reflect on their faith but also serve as a bridge to understanding the divine essence that Jesus embodies.

Jesus in Art: A Historical Overview

Throughout history, the figure of Jesus has been a central subject in art, reflecting the evolving perceptions of His life and teachings. In the early Christian period, artists often depicted Jesus symbolically, emphasizing His divine nature through simple icons and images of the Good Shepherd. These representations focused on His role as a savior and protector, with less emphasis on human features, allowing believers to connect spiritually rather than physically.

As the Middle Ages approached, the depiction of Jesus grew more humanized, inspired by the need for relatable imagery. Artists began to illustrate key events in His life, such as the Nativity and the Crucifixion, which led to the creation of Jesus Birth Images and Jesus Easter Images. This shift illustrated a deep yearning for connection between the divine and the everyday lives of people, allowing for a more intimate understanding of Jesus' experiences and sacrifices.

The Renaissance marked a significant turning point in artistic expressions of Jesus, where the blending of divine and human characteristics reached new heights. Artists like Leonardo da Vinci and Michelangelo interpreted Jesus with exquisite detail and emotional depth, showcasing not only His divinity but also His humanity. These masterpieces continue to resonate, influencing modern depictions and allowing believers to encounter the essence of Jesus through various artistic lenses.

Easter Imagery: Celebrating the Resurrection



Easter is a time of profound joy and renewal, and the imagery associated with this sacred occasion reflects the core of the Christian belief in resurrection. Depictions of Jesus emerging from the tomb, radiant with divine light, illustrate the triumph over death and the promise of eternal life. Artists throughout the centuries have captured this moment, using vibrant colors and dynamic compositions to convey the excitement and hope that surrounds the resurrection. https://telegra.ph/Visions-of-the-Divine-The-Enduring-Allure-of-Jesus-in-Art-09-04 serve not only as reminders of faith but also inspire believers to celebrate the new life that Easter represents.

In many Easter images, we see the symbols of new beginnings intertwined with the visual narratives. https://postheaven.net/dancearm0/visualizing-faith-the-timeless-allure-of-jesus-images is often surrounded by blooming flowers, symbolizing rebirth and fresh starts. Jesus is frequently shown in the company of angels, further emphasizing the divine nature of his resurrection. Such representations encourage reflection on the transformative power of faith and the joy that comes with believing in miracles. These artworks enrich the Easter experience and invite contemplation of the depth of Jesus' sacrifice and victory.

The Good Morning Jesus images that circulate during this season also carry a message of hope and renewal. They present peaceful scenes where Jesus greets his followers, encouraging them to embrace the day with faith and gratitude. These representations resonate deeply with individuals, reminding them that each new morning is an opportunity for spiritual growth and connection with the divine. The combination of these images creates a vivid tapestry of belief, celebrating the essence of Jesus and the everlasting impact of his resurrection on the hearts of Christians around the world.

The Birth of Jesus: Artistic Interpretations

Throughout history, artists have sought to capture the miraculous event of Jesus' birth, translating the profound significance of this moment into visual form. The nativity scene, depicting Mary, Joseph, and the newborn Jesus in the humble surroundings of a stable, has become a central theme in Christian art. Artists like Leonardo da Vinci and Giotto have portrayed this scene with a focus on the divine light emanating from the infant, symbolizing hope and salvation. https://www.openlearning.com/u/armstrongmattingly-sja4il/blog/VisionsOfDivinityExploringTheArtOfJesusImagery of light and shadow in these works emphasizes the extraordinary nature of the event, inviting viewers to reflect on the miraculous aspect of Jesus' arrival into the world.

Various artistic interpretations have emerged, each reflecting the culture and context of the time. In medieval art, the nativity was often depicted with ornate details and symbolism, highlighting the holiness of the moment and the reverence surrounding the birth of Christ. In contrast, Renaissance artists brought a sense of humanity to the scene, emphasizing the tenderness between Mother and Child, portraying them with rich colors and lifelike expressions. These images convey not only the significance of the birth of Jesus but also the warmth of family and the joy of new beginnings.

In modern art, interpretations of the birth of Jesus have become more abstract and varied, often challenging traditional representations. Some artists focus on the social implications of the nativity, highlighting themes of humility and compassion in light of contemporary issues. Others utilize innovative techniques and materials to evoke a sense of wonder and mystique. Regardless of the style, these artistic expressions continue to inspire and provoke contemplation of the profound mystery surrounding the birth of Jesus, inviting viewers to experience the essence of this pivotal moment in Christian belief.