To judge the effect of a multidisciplinary team (MDT) therapy modality on effects of clients with colorectal cancer with liver metastases (CRLMs) in China. We retrospectively identified 236 (MDT 46, non-MDT 190) patients who underwent liver resection or multiple resection for main colorectal cancer and liver metastases with a curative intent for CRLMs during the National Cancer Center between January 2014 and June 2018. A 12 propensity score matching (PSM) analysis was utilized to modify for differences in standard qualities between the MDT team as well as the non-MDT team. After the 12 PSM analysis, 46 customers were assigned to the MDT group, and 83 patients were assigned to the non-MDT group. All analytical analyses were carried out making use of SPSS Statistics, variation 22 (Armonk, NY, American). Statistical relevance was set at a 2-sided P<0.05. Before PSM evaluation, in comparison to non-MDT clients, MDT customers had worse biological qualities and had been almost certainly going to have node-positive major tumors (80.4% vs. 63.2%), several liver metastases (73.9% vs. 50.5%), and liver metastases with a bilobar distribution (73.9% vs. 50.5%). Nevertheless, MDT patients had a tendency towards much better overall survival (OS) (P=0.169, median OS 49.7 months vs. 35.2 months). After PSM analysis, no variations in clinicopathologic variables were identified amongst the MDT group and the non-MDT team. Compared to non-MDT clients, MDT clients had a tendency towards better OS (P=0.063, median OS 49.7 vs. 34.1 months). Multivariate analysis indicated that having an MDT (HR, 0.550, 95% CI 0.309-0.977, P=0.041) was a completely independent predictor of much better OS. The MDT therapy modality can dramatically improve the results of CRLMs clients with bad biological attributes in Asia.The MDT therapy modality can dramatically improve the effects of CRLMs clients with poor biological faculties in Asia. The clinical characteristics and risk factors of catheter-associated endocrine system attacks (CAUTIs) brought on by Klebsiella pneumoniae (KP) have not been really examined. This retrospective study done at an institution teaching hospital in China from January 2012 to November 2017 examined data for 227 clients with urinary tract infection (UTI) caused by KP. Customers' demographic characteristics and clinical outcomes had been recorded. Threat elements were analyzed utilizing a binary logistic regression model. Of 227 clients with Klebsiella pneumoniae-related urinary tract Infection (KP-UTI), the disease was catheter-associated in 90 customers. Over fifty percent of them were male (60%), over 60 yrs . old, hospitalized as a whole ward, constantly acquired in hospital, and got a longer hospitalization more than one thirty days. The Klebsiella pneumoniae-related catheter-associated urinary tract attacks (KP-CAUTIs) patients constantly coupled with plenty of chronic comorbidities. A top proportion of unpleasant product, extendeciated with ESBL appearance and in-hospital mortality in clients with KPCAUTI. The research aimed to investigate the connection amongst the aerobic exercise strength dependant on 6-minute walking distance (6MWD) and its particular counterpart centered on anaerobic limit (AT) in persistent heart failure (CHF) individuals for checking out suitable means for CHF exercise rehabilitation. We retrospectively examined information in patient https://syn-117inhibitor.com/hereditary-variety-as-well-as-ancestry-of-cocoa-theobroma-chocolate-d-throughout-dominica-unveiled-by-simply-one-nucleotide-polymorphism-indicators/ with CHF, who performed cardiopulmonary exercise test (CPET) and 6-minute walking test (6MWT) uniformly. Anthropometric characteristics, left ventricular ejection small fraction (LVEF), and multiple variables of 6MWT and AT were gathered. The results associated with the analysis revealed that the 6MWD was correlated because of the AT positively [CHF group r=0.433, heart failure with just minimal ejection fraction (HFrEF) group r=0.395, heart failure with advanced ejection fraction (HFmEF) group r=0.477, heart failure with preserved ejection small fraction (HFpEF) team r=0.445; all P<0.05]. The regression analysis showed that the linear equation model developed can predict exercise power based on AT (EIAT) by workout power based on 6MWD (EI6MWD), the aerobic exercise strength based on AT and 6MWD respectively, of CHF clients. Between 2010 and 2016, patients with BM from HCC were included utilising the Surveillance, Epidemiology, and End Results (SEER) program. The risk and prognostic facets for BM had been identified by multivariate logistic and Cox regression model evaluation. The overall survival (OS) and cancer-specific survival (CSS) of HCC customers with BM were evaluated making use of Kaplan-Meier curves with log-rank examinations. An overall total of 141 (0.33%) HCC clients detected with BM were included for analysis. Young age, cyst pathological undifferentiation, no surgery, radiotherapy, no chemotherapy, synchronous bone, or lung metastases had been definitely related to BM into the HCC cohort. The median OS and CSS regarding the BM clients were a few months, although the corresponding survival time in HCC patients without BM had been 13 and 23 months. Ebony race, cyst pathological undifferentiation, lack of chemotherapy, and concomitant lung metastases had been individually linked to the even worse survival. Although the total prognosis of clients with BM from HCC had been excessively bad, a summary of homogeneous and heterogeneous risk aspects had been discovered become notably linked to the occurrence and prognosis of BM in HCC customers. These appropriate elements may provide more important references for individualized treatment in clinical rehearse.Although the general prognosis of clients with BM from HCC had been acutely poor, a list of homogeneous and heterogeneous risk facets were discovered is significantly from the incident and prognosis of BM in HCC clients.

GB is an incredibly complex illness, and despite recent development and advanced level therapeutic techniques, the overall patient's prognosis remains dismal. Innovative methods and integrative methods for approach to condition are urgently needed. The main chromosomal rearrangements t(4;11)(q21;q23) and i(7q), described if the cell line was founded, were verified by fluorescence in situ hybridisation (FISH) and 24-colour karyotyping by M-FISH. Extra cytogenetic abnormalities were examined by further FISH experiments, such as the presence of trisomy 18 as a clonal problem together with breakthrough of 1 chromto re-confirm their particular attributes in the long run. We also evaluated the literature to provide a comparison of key attributes of a few mobile lines harbouring a t(4;11). This could guide researchers in selecting the most suitable study model for this specific form of KMT2A-leukaemia. Sheehan syndrome describes a few medical signs resulting from avascular necrosis of anterior pituitary due to different reasons. We report a case of multiple myeloma patient after one pattern of chemotherapy consisting of bortezomib and dexamethasone diagnosis of Sheehan syndrome with obstinate diarrhoea, low blood sugar, and coma symptom, especially, the fluorodeoxyglucose positron emission tomography (FDG-PET) and mind magnetized https://proteasepathway.com/index.php/affiliation-amongst-age-related-language-muscle-problem-language-pressure-as-well-as-presbyphagia-a-3-dimensional-mri-review/ resonance imaging (MRI) unveiled that the manifestations in the saddle location had been prior to bare sella syndrome. A single management with lenalidomide was presented with both for consolidative and upkeep treatment, and satisfactory efficacy ended up being accomplished. With all the patient today continuing to be in satisfactory medical problem, the prosperity of this treatment has been confirmed. This is basically the first report showing a patient with connected multiple myeloma and seldom seen Sheehan problem, for which lenalidomide was presented with for treatment, and satisfactory efficacy was achieved.This is actually the very first report showing a patient with combined multiple myeloma and hardly ever seen Sheehan problem, for which lenalidomide was handed for therapy, and satisfactory efficacy ended up being accomplished. We employed transient nucleofection of Cas9sgRNA ribonucleoprotein buildings made up of chemically synthesized 2'-O-methyl 3'phosphorothioate-modified sgRNAs and purified Cas9 necessary protein. Insertion-deletion mutation (indel) regularity and dimensions distribution had been assessed via computational deconvolution of Sanger sequencing trace information. We unearthed that this optimized method routinely allows for >90% indel formation in mere 3 days, without the need to create clonal outlines for easy loss-of-function experiments. Usingused for extremely efficient and fast gene knockout, as well as for focused genomic deletions, even yet in hyperdiploid cells (such as GSCs). This represents a very of good use tool for the disease study community whenever wishing to inactivate not only coding genetics, additionally non-coding RNAs, UTRs, enhancers, and promoters. This technique is readily used to diverse cell kinds by varying the nucleofection conditions. The personal orphan receptor TLX (NR2E1) is a vital regulator of neurogenesis, person stem cell maintenance, and tumorigenesis. Nevertheless, little is famous concerning the genetic and transcriptomic events that take place following TLX overexpression in individual cell lines. Mainstream spectral karyotyping had been utilized to determine chromosomal abnormalities, accompanied by fluorescence in situ hybridization (FISH) analysis on chromosome spreads to evaluate TLX DNA content number. Illumina paired-end whole transcriptome sequencing was then performed to characterize recurrent hereditary variations (single nucleotide polymorphisms (SNPs) and indels), expressed gene fusions, and gene phrase pages. Finally, flow cytometry had been used to evaluate cell period distribution. Intriguingly, we show that upon transfection with a vector containing the man TLX gene (eGFP-hTLX), an isochromosome types regarding the long-arm of chromosome 6, thereby resulting in DNA gain regarding the TLX locus (6q21) and upregulation of TLX. Induction associated with the eGFP-hTLX vector further increased TLX expression levels, ultimately causing G0-G1 cellular cycle arrest, hereditary aberrations, modulation of gene phrase habits, and crosstalk with other atomic receptors (AR, ESR1, ESR2, NR1H4, and NR3C2). We identified a 49-gene signature involving central nervous system (CNS) development and carcinogenesis, as well as potentially cancer-driving gene fusions (LARP1-CNOT8 and NSL1-ZDBF2) and deleterious hereditary alternatives (frameshift insertions in the CTSH, DBF4, POSTN, and WDR78 genes). Taken together, these findings illustrate that TLX may play a pivotal part in tumorigenesis via genomic instability and perturbation of cancer-related procedures.Taken collectively, these results illustrate that TLX may play a crucial part in tumorigenesis via genomic uncertainty and perturbation of cancer-related procedures. Phase-change nanodroplets (PCNDs), which are fluid perfluorocarbon nanoparticles, have garnered much attention as ultrasound-responsive nanomedicines. The vaporization sensation happens to be employed to take care of tumors mechanically. But, the ultrasound pressure applied to induce vaporization must certanly be reasonable in order to avoid damage to nontarget tissues. Intracellular distribution of PCNDs reduced ultrasound pressure applied for vaporization to cause cytotoxicity. Confocal laser scanning microscopy and flow cytometry revealed that extended PCND-cell incubation increased PCND uptake and aggregation. This aggregation impact could have added to the cytotoxicity limit reduction result.

To determine the association between experiencing obstetric violence and the incidence of postpartum post-traumatic stress disorder (PTSD). A cross-sectional study with puerperal women was conducted in Spain following ethical approval. The Perinatal Posttraumatic Stress Disorder Questionnaire (PPQ) was administered online. Sociodemographic, clinical, and obstetric violence variables and the risk of dichotomized PTSD (low/high) were studied by bivariate and multivariate analysis with binary logistic regression. 955 women were invited to participate. 53 women refused to participate, three did not complete all survey questions and, finally, 899 women were included. The risk of PTSD (score ≥ 19) using the PPQ was 12.7% (114). The mean score was 9.10 points (SD = 8.52). Risk factors identified were having a delivery plan that was not respected (aOR 2.85, 95% CI 1.56-5.21), elective caesarean delivery (aOR 2.53, 95% CI 1.02-2.26), emergency caesarean section (aOR 3.58, 95% CI 1.83-6.99), admission of the newborn to the neonatal intermediate care unit (aOR 4.95, 95% CI 2.36-10.36), admission to the intensive care unit (aOR 2.25, 95% CI 1.02-4.97), formula feeding on discharge (aOR 3.57, 95% CI 1.32-9.62), verbal obstetric violence (aOR 5.07, 95% CI 2.98-8.63), and psycho-affective obstetric violence (aOR 2.61, 95% CI 1.45-4.67). Various clinical practices were identified with the risk of PTSD, highlighting various types of obstetric violence. Partner support and early breastfeeding were identified as protective factors. Sensitizing professionals is essential to prevent the risk of PTSD.Depending on context and tumor stage, deregulation of autophagy can either suppress tumorigenesis or promote chemoresistance and tumor survival. Histone deacetylases (HDACs) can modulate autophagy; however, the exact mechanisms are not fully understood. Here, we analyze the effects of the broad-spectrum HDAC inhibitors (HDACi) panobinostat and vorinostat on the transcriptional regulation of autophagy with respect to autophagy transcription factor activity (Transcription factor EB-TFEB, forkhead boxO-FOXO) and autophagic flux in neuroblastoma cells. In combination with the late-stage autophagic flux inhibitor bafilomycin A1, HDACis increase the number of autophagic vesicles, indicating an increase in autophagic flux. Both HDACi induce nuclear translocation of the transcription factors FOXO1 and FOXO3a, but not TFEB and promote the expression of pro-autophagic FOXO1/3a target genes. Moreover, FOXO1/3a knockdown experiments impaired HDACi treatment mediated expression of autophagy related genes. Combination of panobinostat with the lysosomal inhibitor chloroquine, which blocks autophagic flux, enhances neuroblastoma cell death in culture and hampers tumor growth in vivo in a neuroblastoma zebrafish xenograft model. In conclusion, our results indicate that pan-HDACi treatment induces autophagy in neuroblastoma at a transcriptional level. Combining HDACis with autophagy modulating drugs suppresses tumor growth of high-risk neuroblastoma cells. These experimental data provide novel insights for optimization of treatment strategies in neuroblastoma.S100P, a small calcium-binding protein, associates with the p53 protein with micromolar affinity. It has been hypothesized that the oncogenic function of S100P may involve binding-induced inactivation of p53. We used 1H-15N HSQC experiments and molecular modeling to study the molecular interactions between S100P and p53 in the presence and absence of pentamidine. Our experimental analysis indicates that the S100P-53 complex formation is successfully disrupted by pentamidine, since S100P shares the same binding site for p53 and pentamidine. In addition, we showed that pentamidine treatment of ZR-75-1 breast cancer cells resulted in reduced proliferation and increased p53 and p21 protein levels, indicating that pentamidine is an effective antagonist that interferes with the S100P-p53 interaction, leading to re-activation of the p53-21 pathway and inhibition of cancer cell proliferation. Collectively, our findings suggest that blocking the association between S100P and p53 by pentamidine will prevent cancer progression and, therefore, provide a new avenue for cancer therapy by targeting the S100P-p53 interaction.Effects of the incorporation of Cr, Ni, Co, Ag, Al, Ni and Pt cations in titanate nanotubes (NTs) were examined on the NOx conversion. The structural and morphological characterizations evidenced that the ion-exchange reaction of Cr, Co, Ni and Al ions with the NTs produced catalysts with metals included in the interlayer regions of the trititanate NTs whereas an assembly of Ag and Pt nanoparticles were either on the nanotubes surface or inner diameters through an impregnation process. Understanding the role of the different metal cations intercalated or supported on the nanotubes, the optimal selective catalytic reduction of NOx by CO reaction (SCR) conditions was investigated by carrying out variations in the reaction temperature, SO2 and H2O poisoning and long-term stability runs. Pt nanoparticles on the NTs exhibited superior activity compared to the Cr, Co and Al intercalated in the nanotubes and even to the Ag and Ni counterparts. Resistance against SO2 poisoning was low on NiNT due to the trititanate phase transformation into TiO2 and also to sulfur deposits on Ni sites. However, the interaction between Pt2+ from PtOx and Ti4+ in the NTs favored the adsorption of both NOx and CO enhancing the catalytic performance.Breast cancer (BC) is one of the most common cancers in women worldwide. Even though the role of estrogen receptor alpha (ERα) is extensively documented in the development of breast tumors, other members of the nuclear receptor family have emerged as important players. https://www.selleckchem.com/products/tl12-186.html Synthetic glucocorticoids (GCs) such as dexamethasone (dex) are commonly used in BC for their antiemetic, anti-inflammatory, as well as energy and appetite stimulating properties, and to manage the side effects of chemotherapy. However, dex triggers different effects depending on the BC subtype. The glucocorticoid receptor (GR) is also an important marker in BC, as high GR expression is correlated with a poor and good prognosis in ERα-negative and ERα-positive BCs, respectively. Indeed, though it drives the expression of pro-tumorigenic genes in ERα-negative BCs and is involved in resistance to chemotherapy and metastasis formation, dex inhibits estrogen-mediated cell proliferation in ERα-positive BCs. Recently, a new natural ligand for GR called OCDO was identified.

The C3 species had similar Vo/Vc, but Me was highest in the grass and lowest in the fern. Among the C4 grasses, shade increased O2 uptake in the light, Vo/Vc and the assimilation quotient (AQ), particularly at low CO2, whilst Me was only substantial at low CO2 where it may contribute 20-50% of maximum electron flow under high light.
The clinical benefit of conversion surgery (CS) for unresectable gastric cancer (GC), whereby unresectable GC responds to chemotherapy and subsequently receives curative-intent surgery, remains unclear. Here, we aimed to clarify the clinical value of CS.

In this retrospective cohort study, we analyzed 175 unresectable GC, who received triple combined chemotherapy between 2004 and 2019. We divided patients into two groups those who underwent CS and those receiving chemotherapy only (CS and C groups, respectively). Propensity score matching was used to minimize confounding bias.

Of 175 cases, 61 (34.9%) underwent CS. R0 resection was obtained in 85.2%. After matching, 44 pairs were selected; there were no significant differences in baseline covariants. Group CS had a significantly better median overall survival (OS) (18.8 vs. 46.0months, p < 0.001), and prolonged progression-free survival (7.4 vs. 25.8months, p < 0.001). Subgroup analysis of OS showed a favorable trend for CS for almost all subgroups. https://www.selleckchem.com/products/azd9291.html Multivariate analysis revealed that good ECOG performance status and CS were associated with a longer OS.

The survival benefit of CS was consistently demonstrated in the univariate and multivariate analysis, even in the matched cohort. Additional large-scale trials are needed for further validation.
The survival benefit of CS was consistently demonstrated in the univariate and multivariate analysis, even in the matched cohort. Additional large-scale trials are needed for further validation.
Self-induced genital trauma is rare, and prompt and evidence-based early intervention can improve the urinary and sexual function of these complex patients. This review has surveyed current literature and treatment trends to evaluate the clinical approach to managing genital trauma.

A literature review was performed regarding self-induced genitalia trauma and trauma management between 2000 and 2019 using MEDLINE® database, the Cochrane Library® Central Search, Web of Science, and Google Scholar. In total, 42 articles were considered relevant and included in this review. Self-induced trauma can be appropriately managed with a multidisciplinary approach. Treatment goals are to preserve urinary, sexual, and reproductive function. Specific evaluation includes mechanism of injury, imaging, and determining the extent of injury and surgical repair, if indicated. Due to the rarity of these injuries and their emergent nature, much of the management is based on retrospective data. Further research is needed to improve long-term functional outcomes in trauma patients.
A literature review was performed regarding self-induced genitalia trauma and trauma management between 2000 and 2019 using MEDLINE® database, the Cochrane Library® Central Search, Web of Science, and Google Scholar. In total, 42 articles were considered relevant and included in this review. Self-induced trauma can be appropriately managed with a multidisciplinary approach. Treatment goals are to preserve urinary, sexual, and reproductive function. Specific evaluation includes mechanism of injury, imaging, and determining the extent of injury and surgical repair, if indicated. Due to the rarity of these injuries and their emergent nature, much of the management is based on retrospective data. Further research is needed to improve long-term functional outcomes in trauma patients.
To report the rate of fetal anomalies detected on anatomy ultrasound in pregnant patients who underwent IVF with preimplantation genetic testing for aneuploidy (PGT-A) compared to patients who conceived following IVF with unscreened embryos and age-matched patients with natural conceptions.

Retrospective cohort study at a single maternal-fetal medicine practice. Patients with singleton pregnancies who had a mid-trimester anatomy ultrasound between January 2017 and December 2018 were screened for inclusion. A total of 712 patients who conceived after IVF with or without PGT-A were age-matched with natural conception controls. The primary outcome was the rate of fetal and placental anomalies detected on mid-trimester anatomical survey. Secondary outcomes included the rates of abnormal nuchal translucency (NT), second trimester serum analytes, non-invasive prenatal testing (NIPT), and invasive diagnostic testing.

There were no differences in the rate of fetal anomalies in patients who underwent IVF with PGions of PGT-A, and of providing standard prenatal care for pregnancies conceived through ART, regardless of whether PGT-A was performed.
To determine the effect of human growth hormone (GH) supplementation during ovarian stimulation in women undergoing IVF/PGT-A cycles, who do not meet the Bologna criteria for poor ovarian response (POR).

This is a retrospective cohort study of 41 women with suboptimal outcomes in their first cycle of IVF/PGT-A including lower than expected number of MII oocytes, poor blastulation rate, and/or lower than expected number of euploid embryos for their age, who underwent a subsequent IVF/PGT-A cycle with the same fixed dose gonadotropin protocol and adjuvant GH treatment. Daily cotreatment with GH started with first gonadotrophin injection. The IVF cycle outcomes were compared between the control and GH cycle using the Wilcoxon-Signed Rank test.

The total number of biopsied blastocysts (mean ± SD; 2.0 ± 1.6 vs 3.5 ± 3.2, p = 0.009) and euploid embryos (0.8 ± 1.0 vs 2.0 ± 2.8, p = 0.004) were significantly increased in the adjuvant GH cycle compared to the control cycle. The total number of MII oocytes also trended to be higher in the GH cycle (10.2 ± 6.3 vs 12.1 ± 8.3, p = 0.061). The overall blastulation and euploidy rate did not differ between the control and treatment cycle.

Our study uniquely investigated the use of adjuvant GH in IVF/PGT-A cycles in women without POR and without a priori suspicion for poor outcome based on their clinical parameters. Our study presents preliminary evidence that GH supplementation in these women is beneficial and is associated with an increased number of blastocysts for biopsy and greater number of euploid embryos for transfer.
Our study uniquely investigated the use of adjuvant GH in IVF/PGT-A cycles in women without POR and without a priori suspicion for poor outcome based on their clinical parameters. Our study presents preliminary evidence that GH supplementation in these women is beneficial and is associated with an increased number of blastocysts for biopsy and greater number of euploid embryos for transfer.

Moreover, a preliminary biological assessment was performed using scaffolds from our In-House printer, measuring cell adhesion efficiency. Finally, Fourier transform infrared spectroscopy - attenuated total reflectance (FTIR-ATR) was performed to evaluate chemical changes in the material (polylactic acid) after fabrication in each printer. The results show that the In-House printer achieved generally better mechanical behavior and resolution capacity than its commercial counterpart, by comparing with their FEA and CAD models, respectively. Moreover, a preliminary biological assessment indicates the feasibility of the In-House printer to be used in tissue engineering applications. The results also show the influence of pore geometry on mechanical properties of 3D-scaffolds and demonstrate that properties such as the apparent elastic modulus (Eapp) can be controlled in 3D-printed scaffolds.Electrospun membranes and hydrogels are widely used to prevent tendon adhesion. Hydrophobic anti-inflammatory drugs could be fully loaded on the electrospinning membrane through the electrospinning process, which can better prevent tendon adhesion. Basic fibroblast growth factor (bFGF) could promote tendon healing. However, the bioactivity of free bFGF is easily inactivated, therefore, a suitable carrier is needed. As a carrier, hydrogel has little effect on the bioactivity of the protein drugs. In this work, a poly(lactic-co-glycolic) acid (PLGA) electrospun membrane loaded with ibuprofen (IBU) was prepared and named EMI. Additionally, Methoxy poly(ethylene glycol)-block-poly(L-valine) (PEG-PLV) was synthesized. bFGF was added to the PEG-PLV solution, a hydrogel containing bFGF (PLVB) was obtained after gelling. PLVB was applied to the surface of EMI, a double-layer composite membrane named EMI-PLVB was obtained. This membrane was used to prevent Achilles tendon adhesion and promote healing. https://www.selleckchem.com/products/crenolanib-cp-868596.html IBU and bFGF in EMI-PLVB were continuously released in vitro. The inflammatory factors at the tendon healing site were significantly reduced, and the production of type I collagen (Col- I) and type III Collagen (Col-III) at the tendon healing site was also increased in vivo. In conclusion, this double-layer composite membrane drug release system can effectively prevent tendon adhesion and promote tendon healing.Inflammatory cells orchestrate tumor niche for the proliferating neoplastic cells, leading to neoangiogenesis, lymphangiogenesis, tumor growth and metastasis. Emergence of severe side effects, multiple drug resistance and associated high cost has rendered conventional chemotherapy less effectual. The aim was to develop a multipurpose, less toxic, more potent and cheaper, oral non-conventional anticancer therapeutic. Cyclooxygenase associated with tumor niche inflammation and proliferative neoplastic cells were targeted synergistically, through anti-inflammatory and anti-proliferative effects of model drug, diclofenac sodium and fluorescent silver nanoparticles (AgNPs), respectively. Drug entrapped AgNPs were surface modified with PVA (for controlling particle size, preferred cellular uptake, evading opsonization and improved dispersion). XRD, FTIR, DSC, TGA, LIBS, particle size and surface plasmon resonance analysis confirmed the efficient drug encapsulation and PVA coating with 62% loading efficiency. In-vitro, the formulation exhibited 1st order release kinetics with sustained and maximal release at slightly acidic conditions (pH 4.5) enabling the potential for passive tumor targeting. Also, nanoparticles showed efficient protein denaturation inhibition potential, hemo-compatibility ( less then 0.8%) and potent anti-cancer activity (P  less then  0.05) against breast cancer cell line (MCF-7). In-vivo, developed nanoparticles improved pharmacokinetics (2.8 fold increased AUC, 6.9 h t1/2, Cmax = 1.6 ± 0.03 μg/ml, Kel = 0.1) and pharmacodynamics manifested by potent anti-inflammatory, analgesic and anti-pyretic effects (P  less then  0.05) at 20 fold lower doses. LD50 determination revealed a wide therapeutic window. The study showed promise of synthesized nanomaterials as cheaper, less toxic, hemo-compatible, oral and more potent anti-inflammatory and non-conventional fluorescent anti-cancer agents, vanquishing tumor niche inflammation and repressing proliferation of malignant cells.Glutaraldehyde-treated, surgical bioprosthetic heart valves undergo structural degeneration within 10-15 years of implantation. Analogous preliminary results were disclosed for percutaneous heart valves (PHVs) realized with similarly-treated tissues. To improve long-term performance, decellularised scaffolds can be proposed as alternative fabricating biomaterials. The aim of this study was to evaluate whether bovine and porcine decellularised pericardia could be utilised to manufacture bioengineered percutaneous heart valves (bioPHVs) with adequate hydrodynamic performance and leaflet resistance to crimping damage. BioPHVs were fabricated by mounting acellular pericardia onto commercial stents. Independently from the pericardial species used for valve fabrication, bioPHVs satisfied the minimum hydrodynamic performance criteria set by ISO 5840-3 standards and were able to withstand a large spectrum of cardiac output conditions, also during extreme backpressure, without severe regurgitation, especially in the case of the porcine group. No macroscopic or microscopic leaflet damage was detected following bioPHV crimping. Bovine and porcine decellularized pericardia are both suitable alternatives to glutaraldehyde-treated tissues. Between the two types of pericardial species tested, the porcine tissue scaffold might be preferable to fabricate advanced PHV replacements for long-term performance. CONDENSED ABSTRACT Current percutaneous heart valve replacements are formulated with glutaraldehyde-treated animal tissues, prone to structural degeneration. In order to improve long-term performance, bovine and porcine decellularised pericardia were utilised to manufacture bioengineered replacements, which demonstrated adequate hydrodynamic behaviour and resistance to crimping without leaflet architectural alteration.